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Vitiligo repigmentation

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https://www.readbyqxmd.com/read/29318598/efficacy-and-safety-of-noncultured-melanocyte-keratinocyte-transplant-procedure-for-vitiligo-and-other-leukodermas-a-critical-analysis-of-the-evidence
#1
REVIEW
Paras P Vakharia, Dylan E Lee, Amor Khachemoune
Vitiligo is an acquired pigmentary skin of depigmentation occurring secondary to melanocyte destruction. Vitiligo and other leukodermas have a profound impact on quality of life. Current therapies include medical options, such as phototherapy, topical and systemic corticosteroids, topical calcineurin inhibitors, immunomodulators, and antioxidiants, and surgical options. Surgical options provide melanocytic cells to previously depigmented areas and use either tissue grafting or cellular grafting methods. Topical treatments are often insufficient, and many of the current surgical procedures have shown variable response rates...
January 10, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29318595/the-early-repigmentation-pattern-of-vitiligo-is-related-to-the-source-of-melanocytes-and-by-the-choice-of-therapy-a-retrospective-cohort-study
#2
Ke Yang, Xixi Xiong, Gorkhali Pallavi, Yuting Ling, Fei Ding, Weiwei Duan, Weiling Sun, Gaozhong Ding, Qingli Gong, Wenyuan Zhu, Yan Lu
BACKGROUND: Patients with vitiligo present with different repigmentation patterns in the early recovery stage. OBJECTIVES: To analyze the relationships between early repigmentation patterns in vitiliginous patches, their clinical characteristics, and therapeutic choices. METHODS: Patients with vitiligo seen in the Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University from 2010 to 2015, were included, and their clinical records, especially photographs and medical treatments, were reviewed...
January 10, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29282672/successful-treatment-of-refractory-vitiligo-with-a-combination-of-khellin-and-308-nm-excimer-lamp-an-open-label-1-year-prospective-study
#3
Samy Fenniche, Anissa Zaouak, Azima Ben Tanfous, Meriem Jrad, Houda Hammami
INTRODUCTION: Phototherapy is the cornerstone of treatment of vitiligo. The 308-nm excimer lamp (EL) induces T cell apoptosis and the stimulation of melanocyte proliferation. Khellin is a furanochromone with a chemical structure close to psoralens. The objective of the study was to evaluate the safety and efficacy of 1-year treatment of recalcitrant vitiligo with a combination of 308-nm EL and khellin. METHODS: Twenty patients with resistant vitiligo were included...
December 27, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29234546/repigmentation-of-tenacious-vitiligo-on-apremilast
#4
Sara B Huff, Lorie D Gottwald
Vitiligo is a common pigment disorder characterized by acquired loss of function or absence of melanocytes, leading to distinct areas of depigmentation. Physical exam reveals sharply demarcated, depigmented macules or patches on otherwise normal skin. Vitiligo can present at any age, in any skin color. There is no specific serologic marker for diagnosis, but patients often have other autoimmune problems. Treatment options are limited and are difficult given the fact that the pathogenesis of the disease is not well elucidated...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29186240/evaluation-of-treatment-response-to-autologous-transplantation-of-noncultured-melanocyte-keratinocyte-cell-suspension-in-patients-with-stable-vitiligo
#5
Mariana Gontijo Ramos, Daniel Gontijo Ramos, Camila Gontijo Ramos
BACKGROUND: Vitiligo is a chronic disease characterized by the appearance of achromic macules caused by melanocyte destruction. Surgical treatments with melanocyte transplantation can be used for stable vitiligo cases. OBJECTIVES: To evaluate treatment response to the autologous transplantation of noncultured epidermal cell suspension in patients with stable vitiligo. METHODS: Case series study in patients with stable vitiligo submitted to noncultured epidermal cell suspension transplantation and evaluated at least once, between 3 and 6 months after the procedure, to observe repigmentation and possible adverse effects...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29123631/comparison-between-311-312-nm-narrow-band-ultraviolet-b-phototherapy-and-308-nm-monochromatic-excimer-light-phototherapy-in-treatment-of-vitiligo-a-histopathological-study
#6
Manal Mohamed Salah Eldin, Nevein Ahmed Sami, Dalia Gamal Aly, Noha Sami Hanafy
Introduction: Recently, the monochromatic excimer light (MEL) of 308 nm wavelength has shown some advantages in comparison to narrow band ultraviolet B (NB-UVB) for the treatment of vitiligo. To histopathologically compare the early effects of NB-UVB and 308-nm MEL phototherapy on vitiliginous patches using H&E and HMB-45. Methods: Thirty subjects with non-segmental vitiligo lesions were treated twice a week for 6 weeks with 308-nm MEL, while NB-UVB was used to treat lesions contra laterally. Skin biopsies were taken from lesional areas before and after 6 weeks of treatment by either modality...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29103774/a-single-arm-open-label-clinical-trial-of-autologous-epidermal-cell-transplantation-for-stable-vitiligo-a-30-month-follow-up
#7
Zahra Orouji, Amir Bajouri, Mahshid Ghasemi, Parvaneh Mohammadi, Nasrin Fallah, Atefeh Shahbazi, Mohammad Rezvani, Fatemeh Vaezirad, Zahra Khalajasadi, Ahad Alizadeh, Ehsan Taghiabadi, Sara Dashtbozorgi, Raheleh Aghdami, Seyedeh Esmat Hosseini, Hossein Bahahrvand, Saeed Shafieyan, Nasser Aghdami
BACKGROUND: Recently, we introduced intralesional injection of autologous epidermal cells as a safe and feasible approach for transplantation in patients with stable vitiligo. This approach resulted in less pain during and after the procedure, no scarring or cobblestone formation at the recipient site, and was more feasible to perform on curved surfaces such as joints, lips, eyelids, ears, and face. OBJECTIVE: In this study, we aimed to investigate the long-term efficacy and safety of this transplantation technique...
October 18, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29080365/narrow-band-uvb-effects-on-cutaneous-vitamin-d-receptor-expression-and-serum-25-hydroxyvitamin-d-in-generalized-vitiligo
#8
Hala M El-Hanbuli, Noha M Dawoud, Rania H Mahmoud
BACKGROUND/PURPOSE: Vitamin D has a role in variety of autoimmune diseases including vitiligo. Narrow-band UVB (NB-UVB) treatment of vitiligo might act through its effects on vitamin D and its receptor.This study is the first to elucidate NB-UVB effects on immunohistochemical vitamin D receptor (VDR) expression in generalized vitiligo and correlate it with serum vitamin D and repigmentation response. METHODS: Using immunohistochemistry, VDR expression was estimated in skin biopsies of 30 controls and 30 vitiligo patients; from vitiligo lesion, perilesional skin at baseline and from repigmented and nonresponding skin after 24 NB-UVB sessions...
October 28, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29054607/repigmentation-of-human-vitiligo-skin-by-nbuvb-is-controlled-by-transcription-of-gli1-and-activation-of-%C3%AE-catenin-pathway-in-the-hair-follicle-bulge-stem-cells
#9
Nathaniel B Goldstein, Maranke I Koster, Kenneth L Jones, Bifeng Gao, Laura G Hoaglin, Steven E Robinson, Michael J Wright, Smaranda I Birlea, Abigail Luman, Karoline A Lambert, Yiqun G Shellman, Mayumi Fujita, William A Robinson, Dennis R Roop, David A Norris, Stanca A Birlea
Vitiligo repigmentation is a complex process in which the melanocyte-depleted interfollicular epidermis (IE) is repopulated by melanocyte precursors from hair follicle (HF) bulge that proliferate, migrate, and differentiate into mature melanocytes on their way to the epidermis. The strongest stimulus for vitiligo repigmentation is narrow band UVB (NBUVB), but how the HF melanocyte precursors are activated by UV light has not been extensively studied. To better understand this process, we developed an application that combined laser capture microdissection and subsequent whole transcriptome RNA sequencing of HF bulge melanocyte precursors, and compared their gene signature to that of regenerated mature epidermal melanocytes from the NBUVB-treated vitiligo skin...
October 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29034590/bimatoprost-ophthalmic-solution-in-facial-vitiligo
#10
Abhijeet K Jha, Smita Prasad, Rajesh Sinha
BACKGROUND: Vitiligo is one of the commonest pigmentary disorders characterized by destruction of melanocytes. AIM: To evaluate the efficacy of topical bimatoprost ophthalmic solution in stable facial vitiligo. MATERIAL AND METHODS: Eight cases of stable facial vitiligo were treated with bimatoprost 0.03% ophthalmic solution once daily for 12 weeks. Photographic records were taken at 2 weeks follow-up along with dermoscopic (Polarized, 10×) evaluation...
October 15, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29030646/-systemic-treatment-of-vitiligo-balance-and-current-developments
#11
REVIEW
M Meurer, P Ceric-Dehdari
Systemic drug treatment of vitiligo is currently limited to predominantly adjuvant measures for increasing the effectiveness of UV light therapy. We here present new approaches for the systemic treatment of vitiligo currently under clinical investigation. These include the α‑MSH-analogue afamelatonide and oral immunosuppressants such as the Janus kinase (JAK) inhibitors which target interferon-α-dependent autotoxic inflammatory reactions. In 2015 the first publications on the successful systemic use of Janus kinase (JAK) inhibitors in vitiligo appeared...
November 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29019940/effects-of-extremely-low-frequency-electromagnetic-fields-on-melanogenesis-through-p-erk-and-p-sapk-jnk-pathways-in-human-melanocytes
#12
Yu-Mi Kim, Sang-Eun Cho, Soo-Chan Kim, Hyun-Joon Jang, Young-Kwon Seo
This study evaluated frequency-dependent effects of extremely low frequency electromagnetic fields (ELF-EMFs) on melanogenesis by melanocytes in vitro. Melanocytes were exposed to 2 mT EMFs at 30-75 Hz for 3 days before melanogenesis was examined. Exposure to ELF-EMFs at 50 and 60 Hz induced melanogenic maturation without cell damage, without changing cell proliferation and mitochondrial activity. Melanin content and tyrosinase activity of cells exposed to 50 Hz were higher than in controls, and mRNA expression of tyrosinase-related protein-2 was elevated relative to controls at 50 Hz...
October 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28971483/study-of-efficacy-and-safety-of-noncultured-extracted-follicular-outer-root-sheath-cell-suspension-transplantation-in-the-management-of-stable-vitiligo
#13
Pawan Kumar, Neetu Bhari, Manoj K Tembhre, Sujata Mohanty, Sudheer Arava, Vinod K Sharma, Somesh Gupta
BACKGROUND: Noncultured, extracted follicular outer root sheath suspension (NC-EHF-ORS-CS) is a recently introduced technique for the treatment of stable vitiligo. OBJECTIVE: To study the clinical efficacy of this technique and to determine the viability and cell composition of the suspension. METHODS: Twenty-five patients with stable vitiligo were included in this prospective study. Fifty follicles were extracted from occipital scalp and were incubated with trypsin-ethylenediaminetetraacetic acid to separate outer root sheath cells...
October 3, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28966532/repigmentation-in-a-vitiligo-universalis-patient-chemotherapy-induced-or-spontaneous
#14
So Min Kim, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim
No abstract text is available yet for this article.
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28941491/vitiligo-surgery-shuffling-melanocytes
#15
REVIEW
Amanda F Nahhas, Tasneem F Mohammad, Iltefat H Hamzavi
Vitiligo is a disorder characterized by the development of depigmented macules and patches secondary to melanocyte destruction. Several treatment options are available, including medical, light-based, and surgical therapies, that are often used in combination to achieve maximal repigmentation. Vitiligo surgery is an effective yet underperformed treatment, mainly because of lack of awareness and availability. The purpose of this article is to review one method of vitiligo surgery, the melanocyte-keratinocyte transplantation procedure, and discuss its utility in treating vitiligo...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28927891/vitiligo-skin-is-imprinted-with-resident-memory-cd8-t-cells-expressing-cxcr3
#16
Katia Boniface, Clément Jacquemin, Anne-Sophie Darrigade, Benoît Dessarthe, Christina Martins, Nesrine Boukhedouni, Charlotte Vernisse, Alexis Grasseau, Denis Thiolat, Jérôme Rambert, Fabienne Lucchese, Antoine Bertolotti, Khaled Ezzedine, Alain Taieb, Julien Seneschal
Vitiligo is a chronic auto-immune depigmenting skin disorder that results from a loss of melanocytes. Multiple combinatorial factors have been involved in disease development, with a prominent role of the immune system, in particular T cells. After repigmentation, vitiligo frequently recurs in the same area, suggesting that vitiligo could involve the presence of resident memory T cells (TRM). We sought to perform a thorough characterization of the phenotype and function of skin memory T cells in vitiligo. We show that stable and active vitiligo perilesional skin is enriched with a population of CD8 TRM expressing both CD69 and CD103 compared to psoriasis and control unaffected skin...
September 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28906087/phototherapy-for-vitiligo-what-s-new
#17
Andrea Paro Vidolin, Caterina Aurizi, Giovanni Leone
Vitiligo is a disorder characterized by the development of depigmented macules and patches. Existing treatments include topical and systemic immunosuppressants, topical vitamin D analogues in monotherapy or in association with phototherapy, phototherapy and surgical techniques, which together may serve to halt disease progression, stabilize depigmented lesions, and encourage repigmentation. Narrow-band UVB (NB-UVB 310-315 nm) radiation is now considered as the "gold standard" for the treatment of diffuse vitiligo...
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28881630/protective-effect-of-madecassoside-on-h2o2-induced-oxidative-stress-and-autophagy-activation-in-human-melanocytes
#18
Yuting Ling, Qingli Gong, Xixi Xiong, Li Sun, Wene Zhao, Wenyuan Zhu, Yan Lu
BACKGROUND: Centella asiatica (L.) Urb. is a traditional Chinese medicine that has many medical applications, including wound healing and anti-oxidation. Some traditional Chinese Medicine doctors have found that it has therapeutic effects for external use in the repigmentation of vitiligo and post-inflammatory hypopigmentation. This study was designed to evaluate the effects of madecassoside, a major bioactive component of C. asiatica, on oxidative stress in human melanocytes and its possible mechanism of action...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28834191/combined-treatment-with-fractional-carbon-dioxide-laser-autologous-platelet-rich-plasma-and-narrow-band-ultraviolet-b-for-vitiligo-in-different-body-sites-a-prospective-randomized-comparative-trial
#19
Rania Abdelghani, Naglaa A Ahmed, Hanan M Darwish
BACKGROUND: Multiple treatment options are introduced in treatment of vitiligo but the response is unsatisfactory. OBJECTIVE: In this prospective, randomized, comparative trial, we studied the effect of combined treatment with fractional carbon dioxide (CO2 ) laser, platelet-rich plasma (PRP) injection, and narrowband ultraviolet B (NB-UVB) for stable nonsegmental vitiligo regarding repigmentation grade, patient's satisfaction, and side effects. METHODS: Eighty adult patients with localized nonsegmental vitiligo were enrolled in this study...
August 20, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28708646/modified-technique-of-cultured-epithelial-cells-transplantation-on-facial-segmental-vitiligo
#20
Ke-Jia Wu, Lu-Yan Tang, Jian Li, Shu-Jun Chen, Jin-Ran Lin, Qin-Yuan Zhu, Wen-Wen Fu, Jin-Hua Xu, Wen-Yu Wu
BACKGROUND: Cultured epithelial cells transplantation is a known surgical technique for vitiligo. OBJECTIVE: To evaluate the factors influencing efficacy and safety of cultured epithelial cells transplantation in 9-month follow-up. METHODS: Demographic, clinical, and repigmentation outcomes were reviewed for patients with facial segmental vitiligo who had undergone cultured epithelial cells transplantation from November 2013 to July 2015 at the clinic of the Department of Dermatology, Huashan Hospital, China...
September 2017: Journal of Craniofacial Surgery
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