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Vitiligo repigmentation

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https://www.readbyqxmd.com/read/28163468/use-of-dermatoscope-to-monitor-the-repigmentation-of-various-vitiligo-surgical-procedures
#1
Balakrishnan Nirmal
No abstract text is available yet for this article.
October 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28163453/reduction-of-blister-formation-time-in-suction-blister-epidermal-grafting-in-vitiligo-patients-using-a-household-hair-dryer
#2
Shweta Arora, Bikash Ranjan Kar
BACKGROUND: Suction blister epidermal grafting (SBEG) is a simple and effective way of surgical repigmentation in vitiligo. The major problem faced is the time taken for the formation of blisters. Temperature at the suction site is one of the factors affecting the blister formation time. AIMS AND OBJECTIVES: To reduce the blister formation time in SBEG by increasing the surface temperature to 44°C. MATERIALS AND METHODS: This is a left-right comparison study...
October 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28157763/effect-of-procedural-related-variables-on-melanocyte-keratinocyte-suspension-transplantation-in-nonsegmental-stable-vitiligo-a-clinical-and-immunocytochemical-study
#3
Bakr Mohamed El-Zawahry, Samia Esmat, Dalia Bassiouny, Naglaa Sameh Zaki, Rehab Sobhi, Marwah A Saleh, Dalia Abdel-Halim, Rehab Hegazy, Heba Gawdat, Nesrin Samir, Marwa El-Hawary, Zeinab El Maadawi, Heba Gouda, Mervat Khorshied
BACKGROUND: Melanocyte-keratinocyte suspension (M-K susp) is gaining popularity for vitiligo treatment. Few studies have addressed procedure-related variables. OBJECTIVE: To assess the effect of different M-K susp procedure-related variables on the clinical outcome in stable vitiligo. METHODS: This prospective multicenter comparative study included 40 cases with nonsegmental stable vitiligo. Donor site was either a skin graft in noncultured epidermal cell suspension (NCECS) or hair follicle units in outer root sheath hair follicle suspension (ORSHFS)...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28157762/ultrathin-skin-grafting-in-resistant-stable-vitiligo-a-follow-up-study-of-8-years-in-370-patients
#4
Imran Majid, Saher Imran
BACKGROUND: Ultrathin skin grafting (UTSG) is a tissue grafting technique used in resistant stable vitiligo. OBJECTIVE: To assess long-term follow-up results achieved with UTSG in vitiligo. METHODS: Over a span of 8 years, a total of 415 patients with stable vitiligo were treated with UTSG at the authors' institute. Retrospective analysis of results achieved in these patients was performed, and primary end points assessed included the extent and quality of repigmentation achieved and adverse effects from the procedure...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28123462/detection-of-auto-antibodies-and-transplantation-of-cultured-autologous-melanocytes-for-the-treatment-of-vitiligo
#5
Mei-Cai Zhu, Hong-Yu Ma, Zhi Zhan, Cheng-Gang Liu, Wei Luo, Guang Zhao
The aim of the present study was to establish an immunofluorescence method of antibody detection to identify melanocytes in the serum of vitiligo patients. Furthermore, we aimed to establish a method for the culture and proliferation of autologous pure melanocytes and to observe the effect of their transplantation for the treatment of vitiligo. Suspension of epidermal cells with melanocytes was performed using trypsin digestion of normal epiderm from eyelid operation and melanocytes were selectively cultured and proliferated in serum-free M2 medium...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28054375/effects-of-age-of-onset-on-disease-characteristics-in-non-segmental-vitiligo
#6
Berna Solak, Bahar Sevimli Dikicier, Nur C Cosansu, Teoman Erdem
In patients with vitiligo, the clinical and laboratory features of the disease may vary according to time of onset. This is addressed in the literature by only a few studies with conflicting results. The aim of this study was to determine the demographic and clinical features of patients with non-segmental vitiligo and to establish the association between vitiligo and autoimmune diseases with a focus on time of disease onset. A total of 224 vitiligo patients for whom complete medical records were available were evaluated retrospectively...
March 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28029168/trends-in-regenerative-medicine-repigmentation-in-vitiligo-through-melanocyte-stem-cell-mobilization
#7
REVIEW
Stanca A Birlea, Gertrude-E Costin, Dennis R Roop, David A Norris
Vitiligo is the most frequent human pigmentary disorder, characterized by progressive autoimmune destruction of mature epidermal melanocytes. Of the current treatments offering partial and temporary relief, ultraviolet (UV) light is the most effective, coordinating an intricate network of keratinocyte and melanocyte factors that control numerous cellular and molecular signaling pathways. This UV-activated process is a classic example of regenerative medicine, inducing functional melanocyte stem cell populations in the hair follicle to divide, migrate, and differentiate into mature melanocytes that regenerate the epidermis through a complex process involving melanocytes and other cell lineages in the skin...
December 28, 2016: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28003945/autologous-epidermal-grafting-using-a-novel-negative-pressure-epidermal-harvesting-system-in-a-case-of-stable-vitiligo
#8
Aarthi Krishna, Vanathi Thirunavukkarasu, Paru Priyadarshini Navaneetha Krishnan, Nithya Gayathri Devi Danasekaran, Ratnavel Rajendrabose
Vitiligo is a common pigmentary disorder of the skin with a great amount of social stigma attached to it. Though various medical modalities are available for the treatment of stable vitiligo, surgical modality remains the treatment of choice for stable and localized vitiligo. The surgical options range from simple punch grafting to the recent epidermal harvesting methods using a negative pressure unit. Although successful use of multiple methods of epidermal grafting has been reported, most of them are cumbersome and time-consuming...
November 15, 2016: Curēus
https://www.readbyqxmd.com/read/27941720/effectiveness-of-topical-corticosteroid-topical-calcineurin-inhibitors-and-combination-of-them-in-the-treatment-of-vitiligo
#9
P Roy, S K Saha, P C Paul, A K Reza, A K Nandi, S Sultana, S Saha, S M Akhter, S Khatun, M Habibunnahar
Vitiligo is an acquired pigmentary skin disorder which is disfiguring and difficult to treat. Cure and response rates for vitiligo are significantly lower. This study was conducted to evaluate the effectiveness of topical corticosteroid, topical calcineurin inhibitors (tacrolimus) and combination of them in the treatment of vitilligo in two tertiary care Hospital, in the Department of Dermatology and Venereology OPD (out patient department) in Mymensingh Medical College Hospital and Jahurul Islam Medical College Hospital, Bajitpur, Kishoregonj from January 2015 to December 2015...
October 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27930376/excimer-light-treatment-for-idiopathic-guttate-hypomelanosis-a-pilot-study
#10
Jennifer R S Gordon, Kellie E Reed, Katherine R Sebastian, Ammar M Ahmed
BACKGROUND: Idiopathic guttate hypomelanosis (IGH) is a commonly acquired benign leukoderma characterized by multiple discrete, hypo- or depigmented macules often on extremities that can be aesthetically undesirable for patients. This is the first study using excimer laser for treatment. OBJECTIVE: To determine the effectiveness of excimer laser for repigmentation of idiopathic guttate hypomelanosis. METHODS AND MATERIALS: In this longitudinal, split-body controlled, single-blinded pilot study, 6 patients were treated with excimer laser for 12 weeks using the vitiligo protocol...
December 2, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27904182/comparative-study-of-efficacy-of-epidermal-melanocyte-transfer-versus-hair-follicular-melanocyte-transfer-in-stable-vitiligo
#11
Navya Donaparthi, Ajay Chopra
BACKGROUND: Vitiligo surgery has come up a long way from punch skin grafts to epidermal cell suspension and latest to the extracted hair follicle outer root sheath cell suspension (EHFORSCS) transplantation. The progressive development from one technique to the other is always on a quest for the best. In the latest development, EHFORSCS, which is an enriched source of follicular inactive melanocyte (melanocyte stem cells), seems to be a good addition to the prevailing cell-based therapies for vitiligo...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27882588/clinical-and-epidemiological-analysis-in-149-cases-of-rhododendrol-induced-leukoderma
#12
Momoko Yoshikawa, Yasuyuki Sumikawa, Tokimasa Hida, Takafumi Kamiya, Kimi Kase, Yasue Ishii-Osai, Junji Kato, Yuji Kan, Shiori Kamiya, Yuki Sato, Toshiharu Yamashita
Rhododendrol-induced leukoderma is an acquired depigmentation that develops mainly at the contact site after repeated use of skin-whitening cosmetics containing rhododendrol. In most cases, cessation of further depigmentation or occurrence of repigmentation is observed after discontinuing the use of cosmetics. However, some patients develop vitiligo vulgaris through the spread of depigmentation into the non-exposed areas. Our study aims to investigate the patient-specific factors that may affect the extent of depigmentation or repigmentation, as well as development of vitiligo vulgaris...
November 24, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27878842/pharmacologic-treatment-of-vitiligo-in-children-and-adolescents-a-systematic-review
#13
REVIEW
Andreia Freire de Menezes, Fernanda Oliveira de Carvalho, Rosana S S Barreto, Bruno de Santana Silva, Saravanan Shanmugam, Ricardo Queiroz Gurgel, Adriano Antunes de Souza Araújo
BACKGROUND: The true pathogenic mechanism of vitiligo is still unknown. About half of the patients with this disease have onset before the age of 20 years, making it a serious dermatologic disorder in childhood. OBJECTIVES: The objective of this study was to review the literature in a systematic way and identify the main pharmacologic treatments and outcomes in children and adolescents with vitiligo. METHODS: Four databases-the National Library of Medicine (MEDLINE-PubMed), Web of Science, Scopus, and Latin American and Caribbean Health Sciences (LILACS)-were used for the search up to January 2015...
January 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/27864868/repigmentation-in-vitiligo-position-paper-of-the-vitiligo-global-issues-consensus-conference
#14
Emily Y Gan, Viktoria Eleftheriadou, Samia Esmat, Iltefat Hamzavi, Thierry Passeron, Markus Böhm, Tag Anbar, Boon Kee Goh, Cheng-Che E Lan, Harvey Lui, M Ramam, Noufal Raboobee, Ichiro Katayama, Tamio Suzuki, Davinder Parsad, Vaneeta Seth, Henry W Lim, Nanja van Geel, Sanjeev Mulekar, John Harris, Richard Wittal, Laila Benzekri, Yvon Gauthier, Prasad Kumarasinghe, Steven T G Thng, Caio Cesar Silva de Castro, Marwa Abdallah, Charlotte Vrijman, Marcel Bekkenk, Julien Seneschal, Amit G Pandya, Khaled Ezzedine, Mauro Picardo, Alain Taïeb
The Vitiligo Global Issues Consensus Conference (VGICC), through an international e-Delphi consensus, concluded that 'repigmentation' and 'maintenance of gained repigmentation' are essential core outcome measures in future vitiligo trials. This VGICC position paper addresses these core topics in two sections and includes an atlas depicting vitiligo repigmentation patterns and color match. The first section delineates mechanisms and characteristics of vitiligo repigmentation, and the second section summarizes the outcomes of international meeting discussions and two e-surveys on vitiligo repigmentation, which had been carried out over 3 yr...
January 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/27813161/successful-treatment-of-vitiligo-on-the-scalp-of-a-9-year-old-girl-using-autologous-cultured-pure-melanocyte-transplantation
#15
Xin-Gang Wu, Ai-E Xu
Leukotrichia frequently accompanies vitiligo on hairy areas such as the scalp. Treatment with conventional medical therapy is usually unsuccessful because of deficiencies in the melanocyte reservoir. We describe transplantation of autologous cultured pure melanocytes for scalp vitiligo with leukotrichia in a 9-year-old girl, resulting in almost complete and stable repigmentation of skin and hair.
January 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/27785821/paradoxically-dark-spontaneous-repigmentation-a-rare-complication-of-generalized-vitiligo
#16
LETTER
S Agrawal, D A Porto, H W Lim
No abstract text is available yet for this article.
October 27, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27784078/interventions-for-vitiligo
#17
COMMENT
Khaled Ezzedine, Maxine Whitton, Mariona Pinart
Clinical Question: Which interventions are associated with highest efficacy and fewest adverse events for treating vitiligo? Bottom Line: Combination therapies, particularly those involving some form of light (ie, narrowband UV-B) were associated with more improved repigmentation than monotherapies. There was limited evidence to support the association of UV-A alone and UV-B alone with repigmentation for vitiligo. There was moderate evidence to support the association of UV-A and UV-B, when used in combination with psoralens, topical corticosteroids, vitamin D analogues, fluorouracil, azathioprine, and oral prednisolone with improved outcomes for vitiligo...
October 25, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27745746/chemical-leukoderma-associated-with-methylphenidate-transdermal-system-data-from-the-us-food-and-drug-administration-adverse-event-reporting-system
#18
Carmen Cheng, Lois La Grenade, Ida-Lina Diak, Allen Brinker, Robert L Levin
OBJECTIVE: To identify and characterize cases of chemical leukoderma, an underrecognized adverse event, associated with the methylphenidate transdermal system (MTS) reported to the US Food and Drug Administration Adverse Event Reporting System (FAERS). STUDY DESIGN: We searched the Food and Drug Administration Adverse Event Reporting System for reports of chemical leukoderma associated with MTS, received by the Food and Drug Administration from April 6, 2006 to December 23, 2014...
January 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/27699846/treatment-of-childhood-vitiligo-using-tacrolimus-ointment-with-narrowband-ultraviolet-b-phototherapy
#19
Surabhi Dayal, Priyadarshini Sahu, Nidhi Gupta
BACKGROUND/OBJECTIVES: A combination of narrowband ultraviolet B (NBUVB) phototherapy plus topical tacrolimus has been used in adult vitiligo but has not yet been explored in children. We therefore sought to highlight the efficacy of this synergistic combination in childhood vitiligo. The objective was to study the clinical efficacy and safety of a combination of NBUVB with topical tacrolimus ointment 0.03% in childhood vitiligo. METHOD: In this open-label study, 20 children, 4 to 14 years of age, with symmetrical vitiligo lesions were enrolled for 24 weeks...
November 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27696531/effect-of-narrow-band-ultraviolet-b-phototherapy-as-monotherapy-or-combination-therapy-for-vitiligo-a-meta-analysis
#20
Ronghua Li, Meng Qiao, Xiaoyan Wang, Xintong Zhao, Qing Sun
BACKGROUND: The treatment of vitiligo is still one of the most difficult dermatological challenges, although there are many therapeutic options. Narrow band ultraviolet B (NB-UVB) phototherapy is considered to be a very important modality for generalized vitiligo. OBJECTIVE: The aim of this study was to explore whether a combination of NB-UVB and topical agents would be superior to NB-UVB alone for treating vitiligo. METHODS: We searched the electronic databases such as PUBMED, EMBASE, Cochrane Library, and Web of Science...
October 1, 2016: Photodermatology, Photoimmunology & Photomedicine
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