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Tássia Flávia Dias Castro, José Gilmar da Silva Souza, Aline Ferreira Souza de Carvalho, Isadora de Lima Assis, Marcel José Palmieri, Larissa Fonseca Andrade Vieira, Silvana Marcussi, Monica Rodrigues Ferreira Machado, Luis David Solis Murgas
The effects of different concentrations of commercial product based on tebuconazole, on adults of Danio rerio, were evaluated through novel tank diving test and micronucleus and comet assay tests. A total of 320 adult D. rerio were divided into eight tanks and exposed to concentrations of 0; 100; 200 and 300 μg/L the commercial product based on tebuconazole, with their respective replicates at 24, 72 and 96 h. The results showed a behavioral deviation of zebrafish and a significant (p < 0.05) increase in DNA damage as a function of exposed time and different concentrations of the commercial product in relation to the negative control...
June 30, 2018: Environmental Toxicology and Pharmacology
Sarah B Mulkey, Srinivas Kota, Christopher B Swisher, Laura Hitchings, Marina Metzler, Yunfei Wang, G Larry Maxwell, Robin Baker, Adre J du Plessis, Rathinaswamy Govindan
BACKGROUND: Premature infants are vulnerable to destructive brain injury and disturbed neurological development. Prematurity may alter maturation of the central autonomic nervous system (ANS). AIMS: To compare ANS function (using heart rate variability; HRV) between preterm infants with normal neuroimaging at term equivalent age and low-risk term controls. Study design, subjects. We performed a case-control study of preterm infants born ≤28 weeks gestational age that had normal brain imaging and archived continuous EKG data at term equivalent age...
July 16, 2018: Early Human Development
Hua-Wei Huang, Li-Mei Yan, Yan-Lin Yang, Xuan He, Xiu-Mei Sun, Yu-Mei Wang, Guo-Bin Zhang, Jian-Xin Zhou
Postoperative agitation frequently occurs after general anesthesia and may be associated with serious consequences. However, studies in neurosurgical patients have been inadequate. We aimed to investigate the incidence and risk factors for early postoperative agitation in patients after craniotomy, specifically focusing on the association between postoperative pneumocephalus and agitation. Adult intensive care unit admitted patients after elective craniotomy under general anesthesia were consecutively enrolled...
2018: PloS One
Michael J McGinity, Ramesh Grandhi, Joel E Michalek, Jesse S Rodriguez, Aron M Trevino, Ashley C McGinity, Ali Seifi
[This corrects the article DOI: 10.1371/journal.pone.0195827.].
2018: PloS One
Katelynn M Corder, Mariana A Cortes, Aundrea F Bartley, Samantha A Lear, Farah D Lubin, Lynn E Dobrunz
GABAergic dysfunction has been implicated in a variety of neurological and psychiatric disorders, including anxiety disorders. Anxiety disorders are the most common type of psychiatric disorder during adolescence. There is a deficiency of GABAergic transmission in anxiety, and enhancement of GABA transmission through pharmacological means reduces anxiety behaviors. GAD67-the enzyme responsible for GABA production-has been linked to anxiety disorders. One class of GABAergic interneurons, Neuropeptide Y (NPY) expressing cells, is abundantly found in brain regions associated with anxiety and fear learning, including prefrontal cortex, hippocampus and amygdala...
2018: PloS One
Jean Kaeberle
Epilepsy disorders are the most common treatable neurological disorders in childhood. Diagnosis and treatment of these disorders has improved over time. Children with epilepsy/seizure disorder are more likely to have or develop mental health and developmental comorbidities such as depression, anxiety, attention deficit hyperactivity disorder, learning disabilities, and developmental delay compared to children without epilepsy/seizure disorder. If seizures can be controlled, quality of life will improve. This article will review the current medical treatment for seizures and epilepsy, including medications, vagus nerve stimulation (VNS), dietary modifications, and surgical intervention...
July 1, 2018: NASN School Nurse
Konrad Oppelt, Doreen Hähnlein, Jürgen Boschert, Maike Küffer, Paul Alfred Grützner, Matthias Münzberg, Michael Kreinest
PRIMARY OBJECTIVE: We evaluated the neurologic, psychological and vegetative outcome, the health status and changes of the personal and occupational status of patients after traumatic brain injuries (TBIs). Correlations between outcome parameters and basic demographic factors and initial clinical status parameters of the patients were assessed. RESEARCH DESIGN: Monocentric, retrospective follow-up analysis. METHODS AND PROCEDURES: We evaluated the neurologic, psychological and vegetative outcome and health status of patients, who survived TBI with a mean follow-up time of 54 months...
July 19, 2018: Brain Injury: [BI]
Hugo Granda, Sonia de Pascual-Teresa
Over the last years there has been an increasing interest in the possible beneficial effect of polyphenol consumption on neurodegenerative disorders. Since there is a clear impact of environmental factors on the onset and evolution of neurodegenerative conditions, food arises as a promising factor that might be influencing this group of pathologies. The mechanisms by which polyphenols can affect these processes can be through direct interaction with redox signalling or inflammatory pathways but can also be explained by the interaction of dietary polyphenols with either micro- and macronutrients that are known to have neurological effects or by interaction with food contaminants or food associated toxins avoiding their neuronal toxicity...
July 19, 2018: Journal of Agricultural and Food Chemistry
C Liu, L Zhong, X-L Tian, Y-C Han
OBJECTIVE: To explore the effect of 8-MOP on the blood-brain barrier in mice model of cerebral infarction and the underlying mechanism. MATERIALS AND METHODS: Middle cerebral artery occlusion (MCAO) model was established to induce permanent cerebral infarction. The neurological function was observed and scored by the modified longa score method after model establishment. Besides, the water content of brain tissue was measured by the standard dry weight method. Evans blue exudation rate was used to evaluate the effect of 8-MOP on the permeability of the blood-brain barrier...
July 2018: European Review for Medical and Pharmacological Sciences
Chen Ma, Ping Li
This study retrospectively investigated the effectiveness of paroxetine for the treatment of poststroke depression (PSD).Seventy patient cases with PSD were included in this study, and were assigned to an intervention group and a control group equally. All patients received routine treatment in both groups. Additionally, patients in the intervention group underwent paroxetine, while patients in the control group received psychotherapy for a total of 8 weeks intervention. The primary outcomes included depression, measured by Hamilton depression rating scale (HAMD); and anxiety, measured by Hamilton Anxiety Rating Scale (HAMA)...
July 2018: Medicine (Baltimore)
Hui Wang, Rui Xue, Lumei Wu, Wenyuan Ding, Lei Ma
The aim of this study was to compare clinical and radiological outcomes between modified Gallie graft fusion-wiring technique and posterior cervical screw constructs for Type II odontoid fractures, and hope to provide references in decision making and surgical planning for both spinal surgeons and surgically treated patients.This is a retrospective study. By retrieving the medical records from January 2005 to July 2015 in our hospital, 53 Type II odontoid fracture patients were reviewed. According to the instrumentation type, patients were divided into 2 groups: Wiring group and Screw group...
July 2018: Medicine (Baltimore)
Emanuela Caraffa, Gianluca Russo, Serena Vita, Miriam Lichtner, Anna Paola Massetti, Claudio Maria Mastroianni, Vincenzo Vullo, Maria Rosa Ciardi, Camilla Ajassa
RATIONALE: Tuberculous meningitis is a highly morbid, often fatal disease. PATIENT CONCERN: We describe a case of an Italian child. DIAGNOSES:: we diagnosed early a Tuberculous meningitis complicated by the occurrence of hydrocephalus, stroke, and paradoxical reaction with brain pseudo-abscesses. INTERVENTIONS: The child started readily a specific therapy associated with steroids and thalidomide was introduced few month later. OUTCOMES: the patient had a favorable outcome without neurologic sequelae...
July 2018: Medicine (Baltimore)
Mariana Dutra, Mariana V Monteiro, Karina B Ribeiro, Guilherme P Schettino, Andre Carlos Kajdacsy-Balla Amaral
OBJECTIVES: Handovers are associated with medical errors, and our primary objective is to identify missed diagnosis and goals immediately after a shift handover. Our secondary objective is to assess clinicians' diagnostic accuracy in anticipating clinical events during the night shift. DESIGN: Single-center prospective observational cohort study. SETTING: Thirty-bed tertiary ICU in Sao Paulo, Brazil. PATIENTS: Three-hundred fifty-two patient encounters over 44 day-to-night handovers...
July 17, 2018: Critical Care Medicine
Gavin Buckingham, Desiree Holler, Elizabeth E Michelakakis, Jacqueline C Snow
Object interaction requires knowledge of the weight of an object, as well as its shape. The lateral occipital complex (LOC), an area within the ventral visual pathway, is well known to be critically involved in processing visual shape information. Recently, however, LOC has also been implicated in coding object weight before grasping-a result that is surprising because weight is a nonvisual object property that is more relevant for motor interaction than visual perception. Here, we examined the causal role of LOC in perceiving heaviness and in determining appropriate fingertip forces during object lifting...
July 19, 2018: Journal of Cognitive Neuroscience
Amy Armstrong-Javors, Kathryn Berndtson, Caitlin Naureckas Li, Kevin Schwartz
No abstract text is available yet for this article.
July 1, 2018: Clinical Pediatrics
Irina Filchenko, Anna Simanenkova, Svetlana Chefu, Maria Kolapkova, Timur Vlasov
OBJECTIVE: Stroke is a severe complication of type 2 diabetes mellitus. Glucagon-like peptide-1 receptor agonists have been shown to have a neuroprotective effect in experimental diabetes. The aim of this study was to determine if their neuroprotective effect is an independent property of the drug independent of glycaemic control. METHODS: This two-phase study used male Wistar rats. In the first phase, experimental animals were pretreated with liraglutide, while controls received only vehicle...
July 1, 2018: Diabetes & Vascular Disease Research
Roland Brilla, Kaitlin M Woo, Susanne K Seeger
BACKGROUND: There is evidence that time spent in patient care in between patient visits is increasing and a contributor to physician burnout. The extent of this work on providers in the field of headache medicine is unknown. OBJECTIVES: To establish whether headache outpatients require a high level of care in addition to clinic visits, based on the quantity of remote encounters per patient (phone calls and secure email communication to the clinics), in comparison to other neurologic clinics...
July 19, 2018: Headache
Dang-Huy Do, Melanie Ecker, Walter E Voit
Thiol-ene/acrylate shape-memory polymers can be used as base substrates for neural electrodes to treat neurological dysfunction. Neural electrodes are implanted into the body to alter or record impulse conduction. This study characterizes thiol-ene/acrylate polymers to determine which synthesis methods constitute an ideal substrate for neural implants. To achieve a desired T g between 50 and 56.5 °C, curing conditions, polymer thickness, monomer ratios, and water uptake were all examined and controlled for...
August 31, 2017: ACS Omega
Brad G Kurowski, Terry Stancin, H Gerry Taylor, Kelly A McNally, Michael W Kirkwood, Amy Cassedy, Eileen King, McKenna Sklut, Megan E Narad, Shari L Wade
Introduction: The objective of this manuscript is to describe the methodology that will be used to test the comparative effectiveness, feasibility, and acceptability of three formats of family problem solving therapy (F-PST) for improving functional outcomes of complicated mild to severe adolescent TBI. Methods: Three-arm comparative effectiveness, randomized clinical trial (RCT) design. We describe the protocol of a three-arm RCT comparing the effectiveness of three modalities of F-PST to reduce executive dysfunction and behavior problems following TBI in adolescence...
June 2018: Contemporary Clinical Trials Communications
Carolyn M Hendrickson, Stuart L Gibb, Byron Y Miyazawa, Sheila M Keating, Erin Ross, Amanda S Conroy, Carolyn S Calfee, Shibani Pati, Mitchell J Cohen
Background: Complications after injury, such as acute respiratory distress syndrome (ARDS), are common after traumatic brain injury (TBI) and associated with poor clinical outcomes. The mechanisms driving non-neurologic organ dysfunction after TBI are not well understood. Tissue inhibitor of matrix metalloproteinase-3 (TIMP-3) is a regulator of matrix metalloproteinase activity, inflammation, and vascular permeability, and hence has plausibility as a biomarker for the systemic response to TBI...
2018: Trauma surgery & acute care open
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