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https://www.readbyqxmd.com/read/28913922/a-clinically-meaningful-fetal-hemoglobin-threshold-for-children-with-sickle-cell-anemia-during-hydroxyurea-therapy
#1
Jeremie H Estepp, Matthew P Smeltzer, Guolian Kang, Chen Li, Winfred C Wang, Christina Abrams, Banu Aygun, Russell E Ware, Kerri Nottage, Jane S Hankins
Hydroxyurea has proven clinical benefits and is recommended to be offered to all children with sickle cell anemia (SCA), but the optimal dosing regimen remains controversial. Induction of red blood cell fetal hemoglobin (HbF) by hydroxyurea appears to be dose-dependent. However, it is unknown whether maximizing HbF% improves clinical outcomes. HUSTLE (NCT00305175) is a prospective observational study with a primary goal of describing the long-term clinical effects of hydroxyurea escalated to maximal tolerated dose (MTD) in children with SCA...
September 14, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28913319/rare-location-of-castleman-s-disease-in-the-temporal-region-a-case-report-involving-a-young-korean-woman-and-review-of-the-literature
#2
Wan Cheol Ryu, Moon Hyang Park, Hoon Kim, In Chang Koh, Kyu Nam Kim
Castleman's disease (CD) is an uncommon benign lymphoproliferative disorder of unknown etiology. Histopathologically, it is divided into three types: hyaline-vascular, plasma cellular, and multicentric CD. The mass usually presents asymptomatically; however, it can cause non-specific symptoms such as fever and fatigue. Although CD can be found wherever lymph nodes are present, 75% of cases are reported in the mediastinum, and occurrence in the head and neck is rare. Herein, we report a rare case of CD presenting as a superficial mass in the temporal region...
June 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28912408/-results-of-a-drug-use-survey-of-filgrastim-biosimilar-1-filgrastim-bs-syringe-for-inj-mochida-and-f
#3
Tsukasa Teshima, Nao Takigawa, Yuki Makita, Chinatsu Kushiya
With the aim of evaluating the safety and efficacy of filgrastim biosimilar 1(Filgrastim BS syringe for Inj. "MOCHIDA"and "F"), we conducted a drug use results survey of this product for its indications, including mobilization of hematopoietic stem cells into peripheral blood and chemotherapy-induced neutropenia. Of the 518 cases enrolled between August 2013 and July 2015, 495 were selected to be subjects of our safety and efficacy evaluations. 37 cases (7.47%)experienced side effects, which were mainly lower back pain(19, 3...
September 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28906499/-incomplete-poems-syndrome-with-multicentric-castleman-s-disease
#4
P González de la Aleja, M García-Navarro, R Sánchez-Rodríguez, J M Ramos-Rincón
Castleman's disease (CD) is an atypical lymphoproliferative disorder of unknown cause, characterized by non-clonal nodal hyperplastic growth. Two forms of clinical presentation are currently recognized, one localized and the other multicentric, and four histopathologic variants. It is characterized by generalized lymphadenopathy, hepatosplenomegaly, fever and night sweats. CD may present severe pancytopenia, multi-organ failure, lymphoma evolution and it can sometimes be associated with paraneoplastic syndromes such as POEMS syndrome...
September 14, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/28904672/-kikuchi-fujimoto-disease-about-a-case
#5
Sanaa Elfihri, Mustapha Laine, Fouad Kettani, Jaouda Ben Amor, Jamel Eddine Bourkadi
Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is a rare cause of benign cervical adenopathies. It is an anatomoclinic entity of unknown cause. Diagnosis is based on histologic examination of the lymph nodes. Patient's evolution is generally favorable with spontaneous healing after a few weeks. We here report the case of a 9-year old girl presenting with cervical lymphadenopathy associated with fever. Cervical lymph node biopsy showed Kikuchi-Fujimoto disease. Patient's evolution was marked by regression of adenopathies without receiving any treatment...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28893674/seroepidemiology-of-leptospirosis-among-febrile-patients-in-a-rapidly-growing-suburban-slum-and-a-flood-vulnerable-rural-district-in-mozambique-2012-2014-implication-for-the-management-of-fever
#6
Policarpo Ribeiro, Nilesh Bhatt, Sádia Ali, Vanessa Monteiro, Edmilson da Silva, Ilana Teruszkin Balassiano, Carolina Aquino, Nilsa de de Deus, Onelia Guiliche, Argentina Felisbela Muianga, Pascoal Jorge Alho, Virginia Lara Evaristo, Ivan Manhiça, Marco Medeiros, Eduardo Samo Gudo
OBJECTIVE: Leptospirosis, is one of most widespread zoonosis in the world and is caused by spirochetes of the genus Leptospira. In Mozambique, the disease is heavily ignored and its epidemiology is unknown. The objective of this study was to investigate occurrence of leptospirosis in febrile patients. METHODS: A cross-sectional study was conducted among febrile patients between June 2012 and September 2015. A total of 373 paired samples were drawn from febrile patients, of whom 208 were from Caia District Hospital (rural setting) in Sofala province and 165 were from Polana Caniço General Hospital (suburban setting) in Maputo city...
September 8, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28891000/clinical-application-of-modified-bag-of-features-coupled-with-hybrid-neural-based-classifier-in-dengue-fever-classification-using-gene-expression-data
#7
Sankhadeep Chatterjee, Nilanjan Dey, Fuqian Shi, Amira S Ashour, Simon James Fong, Soumya Sen
Dengue fever detection and classification have a vital role due to the recent outbreaks of different kinds of dengue fever. Recently, the advancement in the microarray technology can be employed for such classification process. Several studies have established that the gene selection phase takes a significant role in the classifier performance. Subsequently, the current study focused on detecting two different variations, namely, dengue fever (DF) and dengue hemorrhagic fever (DHF). A modified bag-of-features method has been proposed to select the most promising genes in the classification process...
September 11, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28887627/-sepsis-masquerading-as-delirium
#8
REVIEW
A Seifert, C S Hartog, J Zweigner, W Schummer, K Reinhart
A previously healthy 60-year-old patient presented to the emergency department with severe headache, altered personality and fever. He was treated for bacterial meningitis with delirium of unknown cause but presumed to be due to alcohol withdrawal. Despite receiving the antibiotic therapy regimen recommended for bacterial meningitis the patient's condition rapidly deteriorated with profound delirium and tachypnea. The intensivist who was consulted immediately suspected sepsis-associated organ failure and admitted the patient to the intensive care unit (ICU)...
September 8, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28885354/acute-versus-subacute-community-acquired-meningitis-analysis-of-611-patients
#9
COMPARATIVE STUDY
Tarek Sulaiman, Lucrecia Salazar, Rodrigo Hasbun
Community-acquired meningitis can be classified into acute and subacute presentations by the duration of illness of ≤ or >5 days, respectively. There are currently no studies comparing the clinical features, management decisions, etiologies, and outcomes between acute and subacute presentations.It is a retrospective study of adults with community-acquired meningitis hospitalized in Houston, TX between January 2005 and January 2010. An adverse clinical outcome was defined as a Glasgow Outcome Scale score of ≤4...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28885233/diagnostic-value-of-pct-and-crp-for-detecting-serious-bacterial-infections-in-patients-with-fever-of-unknown-origin-a-systematic-review-and-meta-analysis
#10
Lan Hu, Qiuping Shi, Miao Shi, Ruixia Liu, Chao Wang
BACKGROUND: It is vital to recognize the cause of an infection to enable earlier treatment. Studies have shown that procalcitonin (PCT) and C-reactive protein (CRP) have very high sensitivity and specificity for diagnosing serious bacterial infections (SBIs), with PCT performing better than CRP. METHODS: Multiple databases were searched for relevant studies, and full-text articles involving diagnosis with PCT and CRP were reviewed. All meta-analyses were conducted with Review Manager 5...
September 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28883253/interstitial-lung-disease-as-an-initial-manifestation-of-giant-cell-arteritis
#11
Chisato Konishi, Kazuhiko Nakagawa, Erika Nakai, Kenta Nishi, Ryoichi Ishikawa, Shinya Uematsu, Satoshi Nakao, Masato Taki, Kyohei Morita, Hwang Moon Hee, Chie Yoshimura, Toshiaki Wakayama, Yasuo Nishizaka
Interstitial lung disease (ILD) has rarely been reported as a manifestation of giant cell arteritis (GCA). We herein report a unique case of GCA in a 76-year-old woman who presented with ILD as an initial manifestation of GCA. Ten years before admission, she had been diagnosed with granulomatous ILD of unknown etiology. Corticosteroid therapy induced remission. One year after the cessation of corticosteroid therapy, she was admitted with a persistent fever. After admission, she developed left oculomotor paralysis...
September 6, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28882616/screening-of-inflammatory-bowel-disease-and-spondyloarthritis-for-referring-patients-between-rheumatology-and-gastroenterology
#12
Jesús Sanz Sanz, Xavier Juanola Roura, Daniel Seoane-Mato, Miguel Montoro, Fernando Gomollón
OBJECTIVE: To define clinical screening criteria for spondyloarthritis (SpA) in patients with inflammatory bowel disease (IBD) and vice versa, which can be used as a reference for referring them to the rheumatology or gastroenterology service. METHOD: Systematic literature review and a two-round Delphi method. The scientific committee and the expert panel were comprised of 2 rheumatologists and 2 gastroenterologists, and 7 rheumatologists and 7 gastroenterologists, respectively...
September 4, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28882091/measles-lymphadenopathy-in-a-child-with-pfapa-syndrome
#13
Jefferson Terry, Kelly Brown, Joanne Hiebert, Ghada N Al-Rawahi, J Paul Moxham, Mel Krajden, Agatha N Jassem, Lori Tucker
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is a common cause of periodic fever in children. The pathogenesis of PFAPA is unknown but likely involves immune system dysregulation and may be initiated by an environmental trigger. Tonsillectomy resolves or improves symptoms in some patients, but the reason for this is unknown; moreover, specific abnormalities in tonsillectomy specimens from PFAPA patients have not been described. Here, we report measles virus in tonsil from a child with PFAPA...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28878524/a-microbial-old-friend-with-a-new-face-a-rare-case-of-pyrexia-of-unknown-origin-and-leukemoid-reaction
#14
Sumeet P Mirgh, Virti D Shah, Jehangir S Sorabjee
We present a case of a young male, who presented to us with high-grade fever for more than four weeks, refractory seizures, multiple subcutaneous palpable lumps, and evidence of leukocytosis with predominant left shift on the peripheral smear. The classic "starry-sky" appearance on imaging, generalized muscular uptake on positron emission tomography-computerized tomography scan, and positive serology led to a diagnosis of disseminated cysticercosis. He responded to oral steroids. To the best of our knowledge, disseminated cysticercosis presenting as pyrexia of unknown origin and with a leukemoid reaction has never been reported in literature...
July 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/28873973/effect-of-renal-transcatheter-arterial-embolization-on-quality-of-life-in-patients-with-autosomal-dominant-polycystic-kidney-disease
#15
Tatsuya Suwabe, Yoshifumi Ubara, Akinari Sekine, Toshiharu Ueno, Masayuki Yamanouchi, Noriko Hayami, Junichi Hoshino, Masahiro Kawada, Rikako Hiramatsu, Eiko Hasegawa, Naoki Sawa, Kenmei Takaichi
Background: Currently, there are few strategies for improving the quality of life (QOL) in patients with autosomal dominant polycystic kidney disease (ADPKD) and massive kidneys. Renal transcatheter arterial embolization (TAE) reduces kidney volume, but its impact on QOL in ADPKD patients on hemodialysis is unknown. This study investigated the influence of renal TAE on QOL in ADPKD patients with massive kidneys receiving hemodialysis. Methods: This prospective observational study enrolled 188 ADPKD patients on hemodialysis (92 men and 96 women; mean age 56...
July 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28873442/use-of-a-novel-antigen-expressing-system-to-study-the-salmonella-enterica-serovar-typhi-protein-recognition-by-t-cells
#16
Rosângela Salerno-Gonçalves, Hervé Tettelin, David Lou, Stephanie Steiner, Tasmia Rezwanul, Qin Guo, William D Picking, Vishvanath Nene, Marcelo B Sztein
Salmonella enterica serovar Typhi (S. Typhi), the causative agent of the typhoid fever, is a pathogen of great public health importance. Typhoid vaccines have the potential to be cost-effective measures towards combating this disease, yet the antigens triggering host protective immune responses are largely unknown. Given the key role of cellular-mediated immunity in S. Typhi protection, it is crucial to identify S. Typhi proteins involved in T-cell responses. Here, cells from individuals immunized with Ty21a typhoid vaccine were collected before and after immunization and used as effectors...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28873022/seroprevalence-of-leptospirosis-brucellosis-and-q-fever-in-a-wild-red-deer-cervus-elaphus-population-kept-in-a-fenced-reserve-in-absence-of-contact-with-livestock
#17
Jose María San-Miguel Ayanz, Francisco Javier Garcia-Peña, Paula García-Lunar, Luis Miguel Ortega-Mora, María José Ruano, Gema Álvarez-García, Esther Collantes-Fernández
Wildlife health is of interest for public and animal health because wild animals have been identified as important sentinels for the surveillance for zoonotic pathogens. This work investigated Brucella spp., Coxiella burnetii, and Leptospira spp. infection seroprevalence in a free-ranging red deer population. The study was conducted in a fenced reserve with controlled hunting activity in central Spain with animals that did not have any contact with livestock. Sampling was performed at two time points before and 5 years after the implementation of new management measures, including a reduction in the red deer population in the reserve...
September 5, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28862659/fever-in-children-pearls-and-pitfalls
#18
REVIEW
Egidio Barbi, Pierluigi Marzuillo, Elena Neri, Samuele Naviglio, Baruch S Krauss
Fever in children is a common concern for parents and one of the most frequent presenting complaints in emergency department visits, often involving non-pediatric emergency physicians. Although the incidence of serious infections has decreased after the introduction of conjugate vaccines, fever remains a major cause of laboratory investigation and hospital admissions. Furthermore, antipyretics are the most common medications administered to children. We review the epidemiology and measurement of fever, the meaning of fever and associated clinical signs in children of different ages and under special conditions, including fever in children with cognitive impairment, recurrent fevers, and fever of unknown origin...
September 1, 2017: Children
https://www.readbyqxmd.com/read/28862033/random-forest-based-evaluation-of-raman-spectroscopy-for-dengue-fever-analysis
#19
Saranjam Khan, Rahat Ullah, Asifullah Khan, Anabia Sohail, Noorul Wahab, Muhammad Bilal, Mushtaq Ahmed
This work presents the evaluation of Raman spectroscopy using random forest (RF) for the analysis of dengue fever in the infected human sera. A total of 100 dengue suspected blood samples, collected from Holy Family Hospital, Rawalpindi, Pakistan, have been used in this study. Out of these samples, 45 were dengue-positive based on immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (ELISA) tests. For highlighting the spectral differences between normal and infected samples, an effective machine learning system is developed that automatically learns the pattern of the shift in spectrum for the dengue compared to normal cases and thus is able to predict the unknown class based on the known example...
September 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28856437/diagnosis-and-empirical-treatment-of-fever-of-unknown-origin-fuo-in-adult-neutropenic-patients-guidelines-of-the-infectious-diseases-working-party-agiho-of-the-german-society-of-hematology-and-medical-oncology-dgho
#20
REVIEW
W J Heinz, D Buchheidt, M Christopeit, M von Lilienfeld-Toal, O A Cornely, H Einsele, M Karthaus, H Link, R Mahlberg, S Neumann, H Ostermann, O Penack, M Ruhnke, M Sandherr, X Schiel, J J Vehreschild, F Weissinger, G Maschmeyer
Fever may be the only clinical symptom at the onset of infection in neutropenic cancer patients undergoing myelosuppressive chemotherapy. A prompt and evidence-based diagnostic and therapeutic approach is mandatory. A systematic search of current literature was conducted, including only full papers and excluding allogeneic hematopoietic stem cell transplant recipients. Recommendations for diagnosis and therapy were developed by an expert panel and approved after plenary discussion by the AGIHO. Randomized clinical trials were mainly available for therapeutic decisions, and new diagnostic procedures have been introduced into clinical practice in the past decade...
August 30, 2017: Annals of Hematology
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