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https://www.readbyqxmd.com/read/29332210/pathogen-specific-leptospiral-proteins-in-urine-of-patients-with-febrile-illness-aids-in-differential-diagnosis-of-leptospirosis-from-dengue
#1
R Chaurasia, K C Thresiamma, C K Eapen, B J Zachariah, R Paul, M Sritharan
Leptospirosis and dengue are two commonly seen infectious diseases of the tropics. Differential diagnosis of leptospirosis from dengue fever is often difficult due to overlapping clinical symptoms and lack of economically viable and easy-to-perform laboratory tests. The gold standard for diagnosis is the microscopic agglutination test (MAT). In this study, the diagnostic potential of screening for pathogen-specific leptospiral antigens in urine samples is presented as a non-invasive method of disease diagnosis...
January 13, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29325142/the-effect-of-measuring-serum-doxycycline-concentrations-on-clinical-outcomes-during-treatment-of-chronic-q-fever
#2
S E van Roeden, C P Bleeker-Rovers, L M Kampschreur, M J A de Regt, A Vermeulen Windsant, A I M Hoepelman, P C Wever, J J Oosterheert
Background: First choice treatment for chronic Q fever is doxycycline plus hydroxychloroquine. Serum doxycycline concentration (SDC) >5 μg/mL has been associated with a favourable serological response, but the effect on clinical outcomes is unknown. Objectives: To assess the effect of measuring SDC during treatment of chronic Q fever on clinical outcomes. Methods: We performed a retrospective cohort study, to assess the effect of measuring SDC on clinical outcomes in patients treated with doxycycline and hydroxychloroquine for chronic Q fever...
January 8, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29324231/decoding-a-salmonella-typhi-regulatory-network-that-controls-typhoid-toxin-expression-within-human-cells
#3
Casey C Fowler, Jorge E Galán
Salmonella Typhi is the cause of typhoid fever, a major global health concern. An essential virulence factor of this pathogen is typhoid toxin. In contrast to most AB-type toxins, typhoid toxin is exclusively expressed by intracellular bacteria. The regulatory networks that ensure this unique gene expression pattern are unknown. Here, we developed FAST-INSeq, a genome-wide screening approach to identify S. Typhi genes required for typhoid toxin expression within infected cells. We find that typhoid toxin expression is controlled by a silencing and counter-silencing mechanism through the opposing actions of the PhoP/PhoQ two-component regulatory system and the histone-like protein H-NS...
January 10, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29317112/cannabinoid-disposition-after-human-intraperitoneal-use-an-insight-into-intraperitoneal-pharmacokinetic-properties-in-metastatic-cancer
#4
Catherine J Lucas, Peter Galettis, Shuzhen Song, Nadia Solowij, Stephanie E Reuter, Jennifer Schneider, Jennifer H Martin
BACKGROUND: Medicinal cannabis is prescribed under the provision of a controlled drug in the Australian Poisons Standard. However, multiple laws must be navigated in order for patients to obtain access and imported products can be expensive. Dose-response information for both efficacy and toxicity pertaining to medicinal cannabis is lacking. The pharmacokinetic properties of cannabis administered by traditional routes has been described but to date, there is no literature on the pharmacokinetic properties of an intraperitoneal cannabinoid emulsion...
January 6, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29290098/rotavirus-infection-as-a-frequent-cause-of-neonatal-fever
#5
Ha-Na Kang, Hyun Kyung Park, Hyun-Ju Lee, Jin-Hwa Moon, Jae Won Oh, Chang-Ryul Kim
BACKGROUND: Fever rather than diarrhea or vomiting was the most common symptom of neonatal rotavirus(RV) infection in our previous study. We investigated if RV infection is a major cause of neonatal fever and we compared the clinical characteristics of bacterial infections, viral infections and unknown causes of neonatal fever. METHOD: We reviewed the electronic medical records of 48 newborns of ≤ 28 days who were admitted to the Special Care Nursery of Hanyang University Guri Hospital for fever (≥ 38°C) from 2005 to 2009...
December 31, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29287595/dealing-with-chronic-non-bacterial-osteomyelitis-a-practical-approach
#6
REVIEW
Andrea Taddio, Giovanna Ferrara, Antonella Insalaco, Manuela Pardeo, Massimo Gregori, Martina Finetti, Serena Pastore, Alberto Tommasini, Alessandro Ventura, Marco Gattorno
BACKGROUND: Chronic Non-Bacterial Osteomyelitis (CNO) is an inflammatory disorder that primarily affects children. Although underestimated, its incidence is rare. For these reasons, no diagnostic and no therapeutic guidelines exist. The manuscript wants to give some suggestions on how to deal with these patients in the every-day clinical practice. MAIN BODY: CNO is characterized by insidious onset of bone pain with local swelling. Systemic symptoms such as fever, skin involvement and arthritis may be sometimes present...
December 29, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29282446/refractory-adult-onset-still-s-disease
#7
Wahinuddin Sulaiman, Aris Chandran Abdullah, Jerome Tan Tsen Chuen, Shaffie Baba, Norain Karim
It is often a challenge and a dilemma for clinicians encountering patients with pyrexia of unknown origin. Numerous tests performed to determine the underlying cause often give inconclusive results. We present a 52-year-old man with undulating fever for more than 10 months with persistent hyperferritinaemia, and negative immunological and serological markers. Despite corticosteroids, disease modifying anti-rheumatic agents and immune-modulator therapy, he succumbed to the illness. A diagnosis of refractory Adult onset Still's disease complicated by haemophagocytic lymphohistiocytosis was made...
October 25, 2017: Curēus
https://www.readbyqxmd.com/read/29260744/-clinical-presentation-of-ixodes-tick-borne-borreliosis-caused-by-borrelia-miyamotoi-in-the-context-of-an-immune-response-to-the-pathogen
#8
A E Platonov, M G Toporkova, N M Kolyasnikova, O A Stukolova, A S Dolgova, A V Brodovikova, N A Makhneva, L S Karan, J Koetsveld, G A Shipulin, V V Maleev
Ixodes tick-borne borreliosis caused by Borrelia miyamotoi (ITBB-BM) is a previously unknown infectious disease discovered in Russia. AIM: The present study continues the investigation of the clinical features of ITBB-BM in the context of an immune system-pathogen interaction. SUBJECTS AND METHODS: The study enrolled 117 patients with ITBB-BM and a comparison group of 71 patients with Lyme disease (LD) that is ITBB with erythema migrans. All the patients were treated at the New Hospital, Yekateringburg...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29260654/impact-evaluation-of-seasonal-malaria-chemoprevention-under-routine-program-implementation-a-quasi-experimental-study-in-burkina-faso
#9
Thomas Druetz, Nicolas Corneau-Tremblay, Tieba Millogo, Seni Kouanda, Antarou Ly, Abel Bicaba, Slim Haddad
Seasonal malaria chemoprevention (SMC) for children < 5 is a strategy that is gaining popularity in West African countries. Although its efficacy to reduce malaria incidence has been demonstrated in trials, the effects of SMC implemented in routine program conditions, outside of experimental contexts, are unknown. In 2014 and 2015, a survey was conducted in 1,311 households located in Kaya District (Burkina Faso) where SMC had been recently introduced. All children < 72 months were tested for malaria and anemia...
December 18, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29240644/monocyte-function-and-clinical-outcomes-in-febrile-and-afebrile-patients-with-severe-sepsis
#10
Anne M Drewry, Enyo A Ablordeppey, Ellen T Murray, Catherine M Dalton, Brian M Fuller, Marin H Kollef, Richard S Hotchkiss
INTRODUCTION: Absence of fever is associated with higher mortality in septic patients, but the reason for this is unknown. Immune dysfunction may be a potential link between failure to mount a fever and poor outcomes. The purpose of this study was to evaluate monocyte function and clinical surrogates of immunity (i.e. mortality and acquisition of secondary infections) in febrile and afebrile septic patients. METHODS: Single-center, prospective cohort study of 92 critically ill septic patients...
December 13, 2017: Shock
https://www.readbyqxmd.com/read/29240045/pier-diego-siccardi-1880-1917-and-the-clinica-del-lavoro-in-the-trench-warfare
#11
Michele Augusto Riva, Michela Caramella, Massimo Turato, Giancarlo Cesana
BACKGROUND: The year 2017 marks the centenary of the death of the Italian scientist Pier Diego Siccardi (1880-1917), one of Luigi Devoto's assistants at the "Clinica del Lavoro" in Milan. OBJECTIVES: To commemorate Siccardi and to describe the activities of the physicians of the "Clinica del Lavoro" during World War I. METHODS: A comprehensive analysis was conducted on scientific papers written by Pier Diego Siccardi and by other physicians belonging to the Clinica del Lavoro, in the period 1915-1918...
December 14, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29233110/accounting-for-misclassification-bias-of-binary-outcomes-due-to-underscreening-a-sensitivity-analysis
#12
Nanhua Zhang, Si Cheng, Lilliam Ambroggio, Todd A Florin, Maurizio Macaluso
BACKGROUND: Diagnostic tests are performed in a subset of the population who are at higher risk, resulting in undiagnosed cases among those who do not receive the test. This poses a challenge for estimating the prevalence of the disease in the study population, and also for studying the risk factors for the disease. METHODS: We formulate this problem as a missing data problem because the disease status is unknown for those who do not receive the test. We propose a Bayesian selection model which models the joint distribution of the disease outcome and whether testing was received...
December 12, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29230614/translating-predictions-of-zoonotic-viruses-for-policymakers
#13
Seth D Judson, Matthew LeBreton, Trevon Fuller, Risa M Hoffman, Kevin Njabo, Timothy F Brewer, Elsa Dibongue, Joseph Diffo, Jean-Marc Feussom Kameni, Severin Loul, Godwin W Nchinda, Richard Njouom, Julius Nwobegahay, Jean Michel Takuo, Judith N Torimiro, Abel Wade, Thomas B Smith
Recent outbreaks of Ebola virus disease and Zika virus disease highlight the need for disseminating accurate predictions of emerging zoonotic viruses to national governments for disease surveillance and response. Although there are published maps for many emerging zoonotic viruses, it is unknown if there is agreement among different models or if they are concordant with national expert opinion. Therefore, we reviewed existing predictions for five high priority emerging zoonotic viruses with national experts in Cameroon to investigate these issues and determine how to make predictions more useful for national policymakers...
December 11, 2017: EcoHealth
https://www.readbyqxmd.com/read/29213028/-acute-cholecystitis-due-to-microscopic-polyangiitis-a-case-report
#14
Masaya Kotsuka, Tadashi Tsukamoto, Akishige Kanazawa, Sadatoshi Shimizu, Yoshitaka Nakajima, Shintaro Kodai, Shigeaki Komatsu
A 78-year-old man with chief complaints of cough and lower limb numbness was admitted to our hospital. Serum myeloperoxidase-antineutrophil cytoplasmic antibody titer (MPO-ANCA) was elevated (48.8U/ml), and a diagnosis of microscopic polyangiitis (MPA) was made. After admission, the patient developed a fever and right upper quadrant pain. Ultrasonography and computed tomography revealed an acute cholecystitis of unknown cause, and laparoscopic cholecystectomy was performed. Histopathological examination of the resected gallbladder revealed necrotizing vasculitis along with the infiltration of eosinophils, lymphocytes, and plasma cells around the small arteries in the muscular layer of the gallbladder, which are characteristics of MPA...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29212102/-conservative-treatment-of-an-aseptic-abscess-syndrome-with-splenic-abscesses-in-crohn-s-disease
#15
Thomas Göbel, Jutta Rauen-Vossloh, Hubert Georg Hotz, Andree Boldt, Andreas Erhardt
A 24-year old woman with a history of Crohn's disease developed bloody diarrhea and multiple abdominal abscesses, daily fever, leukocytosis, and elevated CRP several months after her immunosuppressive therapy with azathioprine was stopped. Recurrent abscess punctures did not detect any pathogenic germs and neither clinical nor serological response was achieved by administration of different antimicrobial therapies. Additionally, new splenic abscesses arose despite ongoing therapy. Under the suspicion of the rare aseptic abscess syndrome, representing an auto-inflammatory, extra-intestinal manifestation of Crohn's disease, the antimicrobial therapy was stopped and an intravenous therapy with prednisolone was initiated...
December 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29211836/outbreak-of-severe-histoplasmosis-among-tunnel-workers-dominican-republic-2015
#16
P A Armstrong, J D Beard, L Bonilla, N Arboleda, M D Lindsley, S Chae, D Castillo, R Nuñez, T Chiller, M A de Perio, R Pimentel, S Vallabhaneni
Background: Histoplasmosis is a fungal infection associated with exposure to bat guano. An outbreak of an unknown severe febrile illness occurred among tunnel workers in the Dominican Republic (DR), and resulted in several deaths. We conducted an investigation to confirm etiology and recommend control measures. Methods: A case was defined as fever and ≥2 symptoms consistent with histoplasmosis in a tunnel worker, July-September, 2015. We interviewed workers and family members, reviewed medical records, tested serum and urine for Histoplasma antigen/antibody, and conducted a cohort study to identify risk factors for histoplasmosis and severe infection (intensive care)...
December 2, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29208852/extremely-high-serum-ferritin-an-instrumental-marker-of-masquerading-adult-onset-still-s-disease-with-hemophagocytic-syndrome
#17
Shun Yamashita, Naoko E Furukawa, Tomoyo Matsunaga, Yuka Hirakawa, Masaki Tago, Shu-Ichi Yamashita
BACKGROUND Adult-onset Still's disease (AOSD) is a rare multi-systemic inflammatory disorder of unknown etiology characterized by spiking fever, characteristic rash, and arthritis. It often associates with high serum ferritin levels. CASE REPORT An 88-year-old woman had fever of over 39°C without response to extended-spectrum antibiotics for 6 days. She had non-specific erythema with infiltration on her trunk. She had leukocytosis with neutrophilia of 80%, mild hepatic dysfunction, normal level of rheumatoid factor and antinuclear antibody, thrombocytopenia, elevated d-dimer and soluble interleukin2 receptor, extremely high serum ferritin (78 662 ng/mL), and splenomegaly...
December 6, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29205989/postpericardiotomy-syndrome
#18
Joonas Lehto, Juha Virolainen
Postpericardiotomy syndrome (PPS) is a common complication following cardiac surgery. In most cases it develops 2 to 3 weeks after the operation. An inflammatory reaction develops in the pericardium or pleural space with fever, chest pain and dyspnea as typical symptoms. The disease process is usually self-limiting. At present, the etiology is unknown, but an immunological mechanism is suspected as the cause of the disease. The incidence of PPS is essentially dependent on diagnostic criteria, patient group and type of operation...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29205679/prevalence-and-characteristics-of-human-parechovirus-and-enterovirus-infections-in-febrile-infants
#19
Kentaro Sano, Hiromichi Hamada, Shoko Hirose, Kenta Sugiura, Satoko Harada, Mai Koizumi, Mayumi Hara, Haruna Nishijima, Masakatsu Taira, Atsushi Ogura, Tomoko Ogawa, Jun-Ichi Takanashi
BACKGROUND: Human parechovirus (HPeV) and human non-polio enterovirus (EV) are important causes of fever without sources (FWS) in young infants. Their prevalence and clinical characteristics are largely unknown in Asian countries. This study was conducted to elucidate the epidemiology and clinical characteristics of HPeV and EV infections in febrile young infants in Japan. METHODS: During February 2010 - August 2015, we obtained 53 stool, 44 throat swab, and 20 cerebrospinal fluid (CSF) samples from 56 infants (<3 months) with FWS at a single hospital...
December 5, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29204452/recurrent-lactobacillus-bacteremia-in-a-patient-with-leukemia
#20
Paurush Ambesh, Sarah Stroud, Eva Franzova, Joseph Gotesman, Kavita Sharma, Lawrence Wolf, Stephan Kamholz
Lactobacillus species are a commensal flora of the human gastrointestinal and the female genitourinary tract. Lactobacilli especially the rhamnosus species, are common components of commercial probiotics. They are rarely associated with pathology in immunocompetent people, but they have been known to cause dental caries, bacteremia, and endocarditis in patients with suppressed immune function. Cases of Lactobacillus bacteremia have been reported in patients with acute myeloid leukemia, large granular lymphocytic leukemia, and in transplant recipients...
October 2017: Journal of Investigative Medicine High Impact Case Reports
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