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https://www.readbyqxmd.com/read/28320196/extended-timed-up-and-go-assessment-as-a-clinical-indicator-of-cognitive-state-in-parkinson-s-disease
#1
Tess Evans, Alexa Jefferson, Michelle Byrnes, Sue Walters, Soumya Ghosh, Frank L Mastaglia, Brian Power, Ryan S Anderton
OBJECTIVE: To evaluate a modified extended Timed Up and Go (extended-TUG) assessment against a panel of validated clinical assessments, as an indicator of Parkinson's disease (PD) severity and cognitive impairment. METHODS: Eighty-seven participants with idiopathic PD were sequentially recruited from a Movement Disorders Clinic. An extended-TUG assessment was employed which required participants to stand from a seated position, walk in a straight line for 7m, turn 180° and then return to the start, in a seated position...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319902/ultra-high-sensitivity-of-the-non-immunological-affinity-of-graphene-oxide-peptide-based-surface-plasmon-resonance-biosensors-to-detect-human-chorionic-gonadotropin
#2
Nan-Fu Chiu, Chia-Tzu Kuo, Ting-Li Lin, Chia-Chen Chang, Chen-Yu Chen
Specific peptide aptamers can be used in place of expensive antibody proteins, and they are gaining increasing importance as sensing probes due to their potential in the development of non-immunological assays with high sensitivity, affinity and specificity for human chorionic gonadotropin (hCG) protein. We combined graphene oxide (GO) sheets with a specific peptide aptamer to create a novel, simple and label-free tool to detect abnormalities at an early stage of pregnancy, a GO-peptide-based surface plasmon resonance (SPR) biosensor...
March 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28318449/through-the-lens-of-attachment-relationship-stable-did-active-did-and-other-trauma-based-mental-disorders
#3
Adah Sachs
Some people with DID, despite years of DID-specific therapy (using the three-phase approach, ISSTD, 2011), seem unable to get better. In particular, they seem unable to remain physically safe ("Phase One") and report continued exposure to abuse. As every fresh hurt causes fresh dissociation, their DID becomes further entrenched over time. Moreover, as dissociation makes the person more vulnerable to being re-abused, they become caught up in a vicious cycle, which further obstructs their efforts toward recovery...
February 23, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28318406/use-of-a-shoulder-abduction-brace-after-arthroscopic-rotator-cuff-repair-a-study-on-gait-performance-and-falls
#4
Yuma Sonoda, Takashi Nishioka, Ryo Nakajima, Shinji Imai, Piers Vigers, Taku Kawasaki
BACKGROUND: Fall prevention is essential in patients after arthroscopic rotator cuff repair because of the high risk of re-rupture. However, there are no reports related to falls that occur during the early postoperative period, while the affected limb is immobilized. OBJECTIVES: This study assessed gait performance and falls in patients using a shoulder abduction brace after arthroscopic rotator cuff repair. STUDY DESIGN: Prospective cohort and postoperative repeated measures...
March 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28315846/risk-factors-for-early-psychosis-in-pd-insights-from-the-parkinson-s-progression-markers-initiative
#5
Dominic H Ffytche, Joana B Pereira, Clive Ballard, K Ray Chaudhuri, Daniel Weintraub, Dag Aarsland
BACKGROUND: Parkinson's Disease (PD) psychosis refers to the spectrum of illusions, formed hallucinations and delusions that occur in PD. Visual hallucinations and illusions are thought to be caused by specific cognitive and higher visual function deficits and patients who develop such symptoms early in the disease course have greater rates of cognitive decline and progression to dementia. To date, no studies have investigated whether such deficits are found prior to the onset of PD psychosis...
April 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28315171/the-dilemma-of-adolescent-varicoceles-do-they-really-have-to-be-repaired
#6
REVIEW
Bryan S Sack, Mattias Schäfer, Michael P Kurtz
The primary indication for varicocele repair in adults, that of failed paternity, must be substituted in the adolescent population with surrogate parameters of testicular size differential and semen analysis. Making recommendations based on these two parameters is incredibly difficult because studies often have contradictory findings, different patient populations, and lack of long-term follow up of the key endpoint, paternity. Therefore, it is not a surprise that recommendations for adolescent varicocele repair are general (with some exceptions) and necessarily so because of limitations in quality of evidence...
May 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28303706/selected-eating-behaviours-of-girls-and-boys-attending-sport-oriented-classes
#7
Nicola Szeja, Elżbieta Szczepańska, Karolina Janion, Anna Szymkiewicz, Biruta Lenard, Izabela Dudzik, Anna Kołdon
Background: Eating behaviours play a key role in lives of young people who stay physically active. They influence both their correct development and performance. Objective: Evaluation of selected eating behaviours of girls and boys attending sport-oriented classes and identification of differences between eating behaviours of studied groups. Materials and Methods: 460 students attending sport-oriented classes in Poland participated in the study...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28295982/light-harvesting-and-photocurrent-generation-in-a-conjugated-polymer-nanoparticle-reduced-graphene-oxide-composite
#8
Amitava Patra, Arnab Ghosh, Bikash Jana, Sourav Maiti, Rajesh Bera, Hiren Ghosh
Polymer - graphene nanocomposites are promising candidates towards light harvesting systems such as photocatalysis, photovoltaics; where significant charge separation occurs due to photoinduced electron transfer. Much attention has been paid to use reduced graphene oxide (r-GO) as template for anchoring various nanomaterials due to its efficient electron accepting and transport property. Here, we have prepared Poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV) nanoparticles from MEH-PPV polymer and investigate the change in photophysical properties due to formation of polymer nanoparticles from molecular state by using steady state and time resolved spectroscopy...
March 14, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28295912/training-with-a-balance-exercise-assist-robot-is-more-effective-than-conventional-training-for-frail-older-adults
#9
Kenichi Ozaki, Izumi Kondo, Satoshi Hirano, Hitoshi Kagaya, Eiichi Saitoh, Aiko Osawa, Yoichi Fujinori
AIM: To examine the efficacy of postural strategy training using a balance exercise assist robot (BEAR) as compared with conventional balance training for frail older adults. METHODS: The present study was designed as a cross-over trial without a washout term. A total of 27 community-dwelling frail or prefrail elderly residents (7 men, 20 women; age range 65-85 years) were selected from a volunteer sample. Two exercises were prepared for interventions: robotic exercise moving the center of gravity by the balance exercise assist robot system; and conventional balance training combining muscle-strengthening exercise, postural strategy training and applied motion exercise...
March 10, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28293286/who-seeks-child-and-adolescent-mental-health-care-in-kenya-a-descriptive-clinic-profile-at-a-tertiary-referral-facility
#10
Judy Wanjiru Kamau, Olayinka O Omigbodun, Tolulope Bella-Awusah, Babatunde Adedokun
BACKGROUND: The presence of psychiatric morbidity in the child and adolescent age group is demonstrable in various studies conducted in various settings in Kenya. This study set out to determine the psychiatric morbidity and socio-demographic profile of patients who eventually present for care at a tertiary specialist child and adolescent mental health clinic in Kenya. Knowledge of the patterns of presentation of disorders is crucial for planning of service scale up as well as serving as a useful training guide...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/28291406/validation-of-the-baseline-severity-stratification-of-objective-functional-impairment-in-lumbar-degenerative-disc-disease
#11
Martin N Stienen, Nicolas R Smoll, Holger Joswig, Marco V Corniola, Karl Schaller, Gerhard Hildebrandt, Oliver P Gautschi
OBJECTIVE The Timed Up and Go (TUG) test is a simple, objective, and standardized method to measure objective functional impairment (OFI) in patients with lumbar degenerative disc disease (DDD). The objective of the current work was to validate the OFI baseline severity stratification (BSS; with levels of "none," "mild," "moderate," and "severe"). METHODS Data were collected in a prospective IRB-approved 2-center study. Patients were assessed with a comprehensive panel of scales for measuring pain (visual analog scale [VAS] for back and leg pain), functional impairment (Roland-Morris Disability Index [RMDI] and Oswestry Disability Index [ODI]), and health-related quality of life (HRQOL; EQ-5D and SF-12)...
March 3, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28291178/comparison-of-single-intra-articular-injection-of-novel-hyaluronan-hya-joint-plus-with-synvisc-one-for-knee-osteoarthritis-a-randomized-controlled-double-blind-trial-of-efficacy-and-safety
#12
Shu-Fen Sun, Chien-Wei Hsu, Huey-Shyan Lin, I-Hsiu Liou, Yin-Han Chen, Chia-Ling Hung
BACKGROUND: Viscosupplementation has been widely used for the treatment of knee osteoarthritis. Because we found no well-controlled trial comparing single-injection regimens of hyaluronan for knee osteoarthritis, we compared the efficacy and safety of a single intra-articular injection of a novel cross-linked hyaluronan (HYA-JOINT Plus) with a single injection of Synvisc-One in patients with knee osteoarthritis. METHODS: In a prospective, randomized, controlled, double-blind trial with a 6-month follow-up, 132 patients with knee osteoarthritis (Kellgren-Lawrence grade 2 or 3) were randomized to receive 1 intra-articular injection of 3 mL of HYA-JOINT Plus (20 mg/mL) (n = 66) or 6 mL of Synvisc-One (8 mg/mL) (n = 66)...
March 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28290280/combined-effect-of-shearing-and-cooling-rate-on-the-rheology-of-organogels-developed-by-selected-gelators
#13
A De la Peña-Gil, F M Álvarez-Mitre, M M González-Chávez, M A Charó-Alonso, J F Toro-Vazquez
In this study we investigated the combined effect of shearing and cooling rate in the rheology of organogels developed in high oleic safflower oil by (R)-12-hydroxystearic acid (HSA), its primary amide derivative [(R)-12-hydroxyoctadecanamide, HOA], and the N-octadecyl derivative of HOA [(R)-N-octadecyl-12-hydroxyoctadecanamide, OHOA]. The experimental set up to develop the organogels involved: 1). The use of quiescent (0s(-1)) or shearing (300, 600, and 1200s(-1)) conditions during cooling the gelator solutions (2%) just until achieving the gelator's melting temperature (TM) in the vegetable oil, to then continuing the cooling under static conditions until achieving 15°C) The use of cooling rate protocols involving a constant cooling rate of 1°C/min (CR1) or 10°C/min (CR10) in the shearing and static stages, or variable cooling rates in each stage (i...
March 2017: Food Research International
https://www.readbyqxmd.com/read/28290192/further-construct-validity-of-the-timed-up-and-go-test-as-a-measure-of-ambulation-in-persons-with-multiple-sclerosis
#14
Alon Kalron, Mark Dolev, Uri Givon
BACKGROUND: The importance of mobility impairments in people with multiple sclerosis (PwMS) denotes a need for valid, reliable, sensitive and feasible clinical measuring tools. The Timed Up and Go (TUG) test is a unique mobility measure as it captures other functions apart from walking, ie, rising out of a chair or turning around an object. AIM: To expand the construct validity of the TUG test in PwMS and determine the ability of the TUG score to discriminate between four levels of disability between fallers, recurrent fallers and non-fallers...
March 13, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28289679/efficacy-of-a-student-led-community-based-multifactorial-fall-prevention-program-stay-in-balance
#15
Cheryl A Der Ananian, Melanie Mitros, Matthew Paul Buman
BACKGROUND: Falls are a major public health concern in older adults. Recent fall prevention guidelines recommend the use of multifactorial fall prevention programs (FPPs) that include exercise for community-dwelling older adults; however, the availability of sustainable, community-based FPPs is limited. METHODS: We conducted a 24-week quasi-experimental study to evaluate the efficacy of a community-based, multifactorial FPP [Stay in Balance (SIB)] on dynamic and functional balance and muscular strength...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28289599/quantitative-measures-of-walking-and-strength-provide-insight-into-brain-corticospinal-tract-pathology-in-multiple-sclerosis
#16
Nora E Fritz, Jennifer Keller, Peter A Calabresi, Kathleen M Zackowski
At least 85% of individuals with multiple sclerosis report walking dysfunction as their primary complaint. Walking and strength measures are common clinical measures to mark increasing disability or improvement with rehabilitation. Previous studies have shown an association between strength or walking ability and spinal cord MRI measures, and strength measures with brainstem corticospinal tract magnetization transfer ratio. However, the relationship between walking performance and brain corticospinal tract magnetization transfer imaging measures and the contribution of clinical measurements of walking and strength to the underlying integrity of the corticospinal tract has not been explored in multiple sclerosis...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28288563/is-independence-of-older-adults-safe-considering-the-risk-of-falls
#17
Dorota Talarska, Magdalena Strugała, Marlena Szewczyczak, Sławomir Tobis, Michał Michalak, Izabela Wróblewska, Katarzyna Wieczorowska-Tobis
BACKGROUND: Falls affect approx. 30% of elderly population per year. They cause major injuries and reduce independence of the older adults' functioning. The main objective of the study was to evaluate the degree of independence and find the fall risk factors in the study group. METHODS: The study included 506 - older adults. The study group included patients from GP clinics and members of two senior centers. The study duration was 12 months. Our study tools included EASY- Care Standard 2010 questionnaire, Abbreviated Mental Test Score (AMTS), Index Barthel, Instrumental Activities of Daily Living Scale (IADL), Geriatric Depression Scale (GDS), Timed Up and Go (TUG)...
March 14, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28286923/maintenance-therapies-in-indolent-lymphomas-should-recent-data-change-the-standard-of-care
#18
REVIEW
Michael T Tees, Ian W Flinn
The overall benefit of maintenance therapy for patients with an indolent lymphoma continues to go unanswered. A myriad of variables contribute to the lack of clear clinical guidance. First, the disease course is slow and treatment may not be required for years, requiring a long follow-up to prospectively study. Second, due to the long lag time from study initiation to conclusion, many of the induction therapies used at the onset of the study may not be favored at present, providing a conclusion that cannot be reconciled with current clinical practice...
March 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28286665/parents-experiences-of-discharge-readiness-from-a-swedish-neonatal-intensive-care-unit
#19
Christina Larsson, Ulrika Wågström, Erik Normann, Ylva Thernström Blomqvist
AIM: The aim of this study was to describe how parents experienced the support at, and preparation for discharge from, the NICU and how they experienced the first time at home. DESIGN: A qualitative design with quantitative elements was applied. METHODS: A questionnaire study. Data were analysed using qualitative content analysis with quantitative elements. RESULTS: The majority of included parents felt adequately prepared for going home and sufficiently supported during the first period home...
April 2017: Nursing Open
https://www.readbyqxmd.com/read/28285197/graphene-oxide-functionalized-long-period-grating-for-ultrasensitive-label-free-immunosensing
#20
Chen Liu, Qi Cai, Baojian Xu, Weidong Zhu, Lin Zhang, Jianlong Zhao, Xianfeng Chen
We explore graphene oxide (GO) nanosheets functionalized dual-peak long period grating (dLPG) based biosensor for ultrasensitive label-free antibody-antigen immunosensing. The GO linking layer provides a remarkable analytical platform for bioaffinity binding interface due to its favorable combination of exceptionally high surface-to-volume ratio and excellent optical and biochemical properties. A new GO deposition technique based on chemical-bonding in conjunction with physical-adsorption was proposed to offer the advantages of a strong bonding between GO and fiber device surface and a homogeneous GO overlay with desirable stability, repeatability and durability...
March 9, 2017: Biosensors & Bioelectronics
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