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https://www.readbyqxmd.com/read/29785346/integrated-bioinformatic-changes-and-analysis-of-retina-with-time-in-diabetic-rats
#1
Zekai Cui, Qiaolang Zeng, Yonglong Guo, Shiwei Liu, Jiansu Chen
Diabetic retinopathy (DR) is the most common chronic complication of diabetes. It can cause impaired vision and even blindness. However, the pathological mechanism of DR is still unknown. In the present study, we use bioinformatic analysis to reveal the pathological changes of early DR in a streptozotocin (STZ) induced diabetes rat model. The dataset GSE28831 was downloaded from the Gene Expression Omnibus (GEO) database. To clarify the pathological mechanism of early DR, genes which were up-regulated (UP group) or down-regulated (DOWN group) over time were identified...
2018: PeerJ
https://www.readbyqxmd.com/read/29781467/comprehensive-geriatric-assessment-interprofessional-team-recommendations-for-older-adult-women-with-breast-cancer
#2
Janine Overcash
BACKGROUND: Geriatric oncology incorporates comprehensive geriatric assessment (CGA) and traditional oncology care. OBJECTIVES: The aims are to identify limitations reflected by mean scores on the CGA instruments and describe the CGA recommendations documented in the medical record. METHODS: CGA was administered and consisted of the Timed Up and Go Test, the Activities of Daily Living Scale, the Instrumental Activities of Daily Living Scale, grip strength, falls, pain, the Brief Fatigue Inventory, the Pittsburgh Sleep Quality Index, the Geriatric Depression Scale, the Mini-Cog, and the Mini Nutritional Assessment...
June 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29781289/a-randomised-trial-comparing-spatio-temporal-gait-parameters-after-total-hip-arthroplasty-between-the-direct-anterior-and-direct-lateral-surgical-approaches
#3
Bryn O Zomar, Dianne Bryant, Susan Hunter, James L Howard, Edward M Vasarhelyi, Brent A Lanting
INTRODUCTION: Total hip arthroplasty (THA) is a successful procedure for relieving symptoms of severe osteoarthritis. Surgical approach is a key factor in early recovery and although controversial, little has been written about the direct anterior (DA) approach using objective early measures. METHODS: 78 participants were prospectively enrolled to undergo a THA through either a DA or direct lateral (DL) surgical approach. Outcome measures were collected preoperatively and at discharge from the hospital, and 2-, 6- and 12-weeks...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29781168/association-of-fall-history-with-the-timed-up-and-go-test-score-and-the-dual-task-cost-a-cross-sectional-study-among-independent-community-dwelling-older-adults
#4
Tsuyoshi Asai, Kensuke Oshima, Yoshihiro Fukumoto, Yuri Yonezawa, Asuka Matsuo, Shogo Misu
AIM: To investigate the associations between fall history and the Timed Up and Go (TUG) test (single-TUG test), TUG test while counting aloud backwards from 100 (dual-TUG test) and the dual-task cost (DTC) among independent community-dwelling older adults. METHODS: This cross-sectional study included 537 older adults who lived independently in the community. Data on fall history in the previous year were obtained by self-administrated questionnaire. The single- and dual-TUG tests were carried out, and the DTC value was computed from these results...
May 21, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29780611/myelin-status-is-associated-with-change-in-functional-mobility-following-slope-walking-in-people-with-multiple-sclerosis
#5
E M King, M J Sabatier, M Hoque, T M Kesar, D Backus, M R Borich
Background: The level of myelin disruption in multiple sclerosis patients may impact the capacity for training-induced neuroplasticity and the magnitude of therapeutic response to rehabilitation interventions. Downslope walking has been shown to increase functional mobility in individuals with multiple sclerosis, but it is unclear if myelin status influences therapeutic response. Objective: The current study aimed to examine the relationship between baseline myelin status and change in functional mobility after a walking intervention...
April 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29780431/mathematical-modelling-of-bacterial-meningitis-transmission-dynamics-with-control-measures
#6
Joshua Kiddy K Asamoah, Farai Nyabadza, Baba Seidu, Mehar Chand, Hemen Dutta
Vaccination and treatment are the most effective ways of controlling the transmission of most infectious diseases. While vaccination helps susceptible individuals to build either a long-term immunity or short-term immunity, treatment reduces the number of disease-induced deaths and the number of infectious individuals in a community/nation. In this paper, a nonlinear deterministic model with time-dependent controls has been proposed to describe the dynamics of bacterial meningitis in a population. The model is shown to exhibit a unique globally asymptotically stable disease-free equilibrium ℰ 0 , when the effective reproduction number ℛ VT ≤ 1, and a globally asymptotically stable endemic equilibrium ℰ 1 , when ℛ VT > 1; and it exhibits a transcritical bifurcation at ℛ VT = 1...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29780284/up-regulation-of-ctd-2547g23-4-in-hepatocellular-carcinoma-tissues-and-its-prospective-molecular-regulatory-mechanism-a-novel-qrt-pcr-and-bioinformatics-analysis-study
#7
Dong-Yue Wen, Peng Lin, Hai-Wei Liang, Xia Yang, Hai-Yuan Li, Yun He, Hong Yang, Gang Chen
Background: Dysregulated expression of long non-coding RNAs (lncRNAs) has been reported in the pathogenesis and progression of multiple cancers, including hepatocellular carcinoma (HCC). LncRNA CTD-2547G23.4 is a novel lncRNA, and its role in HCC is still unknown. Here, we aimed to clarify the expression pattern and clinical value of CTD-2547G23.4 and to investigate the prospective regulatory mechanism via bioinformatics analysis in HCC. Methods: To identify differentially expressed lncRNAs in HCC, we downloaded RNA-Seq data for HCC and adjacent non-tumour tissues via The Cancer Genome Atlas (TCGA)...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29780027/relationships-between-functional-fitness-and-cognitive-impairment-in-chinese-community-dwelling-older-adults-a-cross-sectional-study
#8
Mei Yang, Yan Guo, Jie Gong, Mengyao Deng, Niannian Yang, Yaqiong Yan
OBJECTIVE: The aim of this study was to investigate the associations between each functional fitness (FF) domain and cognitive impairment (CI) in Chinese community-dwelling older adults. DESIGN: A community-based, cross-sectional study was conducted. SETTING: Participants were selected by multistage stratified random sampling in Wuhan City, Hubei Province, Central China, during December 2015-May 2016. PARTICIPANTS: A total of 2096 (1031 male and 1065 female) adults older than 65 years were included in our study...
May 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29779442/assessment-of-low-and-high-level-task-performance-in-people-with-transtibial-amputation-using-crossover-and-energy-storing-prosthetic-feet-a-pilot-study
#9
Elizabeth G Halsne, Cody L McDonald, Sara J Morgan, Sarah M Cheever, Brian J Hafner
BACKGROUND: Crossover feet incorporate features of energy-storing feet and running-specific feet. As such, crossover feet may be suitable for both daily ambulation and participation in physically demanding activities. OBJECTIVES: To compare crossover feet and energy-storing feet on performance-based tests including a range of low-level (e.g. sit-to-stand) and high-level (e.g. jogging) activities. STUDY DESIGN: Cross-sectional, repeated measures...
May 1, 2018: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/29778065/reliability-of-the-sub-components-of-the-instrumented-timed-up-and-go-test-in-ambulatory-children-with-traumatic-brain-injury-and-typically-developed-controls
#10
Mark A Newman, Mark A Hirsch, Richard D Peindl, Nahir A Habet, Tobias J Tsai, Michael S Runyon, Toan Huynh, Nigel Zheng
BACKGROUND: Studies have evaluated the test-re-test reliability of subcomponents of the timed up and-go test in adults by using body-worn inertial sensors. However, studies in children have not been reported in the literature. RESEARCH QUESTION: To evaluate the within-session reliability of subcomponents of a newly developed electronically augmented timed 'upand-go' test (EATUG) in ambulatory children with traumatic brain injury (TBI) and children with typical development (TD)...
May 16, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29777475/effects-of-resistance-training-detraining-and-retraining-on-strength-and-functional-capacity-in-elderly
#11
Raphael Luiz Sakugawa, Bruno Monteiro Moura, Lucas Bet da Rosa Orssatto, Ewertton de Souza Bezerra, Eduardo Lusa Cadore, Fernando Diefenthaeler
BACKGROUND: The interruption of training (detraining) results in loss of the gains acquired. Partial retention could occur after detraining, and variation in training stimuli may optimize retraining adaptations. AIM: To evaluate the effect of a resistance-retraining program on strength and functional capacity performance after a detraining period. METHODS: Ten elderly men and women (63-68 years) completed 12 weeks of training, 16 weeks of detraining, and 8 weeks of retraining...
May 17, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29775118/blood-flow-restricted-resistance-training-in-patients-with-sporadic-inclusion-body-myositis-a-randomized-controlled-trial
#12
A N Jørgensen, P Aagaard, U Frandsen, E Boyle, L P Diederichsen
OBJECTIVES: To investigate the effect of 12 weeks of low-load blood-flow restricted resistance (BFR) training on self-reported and objective physical function, and maximal muscle strength in patients with sporadic inclusion body myositis (sIBM). METHOD: Twenty-two patients with sIBM were randomized into a training group (BFR group) or a non-exercising control group, according to CONsolidated Standards Of Reporting Trials (CONSORT) guidelines. The BFR group performed 12 weeks of BFR training twice per week...
May 18, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29772518/brain-state-before-a-memory-probe-and-associative-retrieval-in-older-adults
#13
Jiangyi Xia, Giulia Galli, Leun J Otten
Older individuals' difficulty in remembering events from a particular time and place may be explained by changes in retrieval-related control processes. We investigated how aging affects neural activity leading up to a retrieval probe and how such activity relates to later performance. Electrical brain activity was recorded while healthy younger and older humans memorized visual word pairs consisting of an object word (e.g., doll) preceded by a location word (e.g., garden). Only object words were presented during the memory test, the task being to decide whether an object had been presented earlier and, if so, what location had been paired with it...
April 12, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29772438/itgbl1-promotes-migration-invasion-and-predicts-a-poor-prognosis-in-colorectal-cancer
#14
Xiao Qiu, Jue-Rong Feng, Jun Qiu, Lan Liu, Yang Xie, Yu-Peng Zhang, Jing Liu, Qiu Zhao
Colorectal cancer (CRC) is one of the most common malignancies worldwide; its progression and prognosis are associated with oncogenes. The present study aimed to identify differentially expressed genes (DEGs) and explore the role and potential mechanism of integrin subunit β like 1 (ITGBL1) in CRC. The microarray dataset GSE41258 was used to screen DEGs involved in CRC. Survival analysis was performed to predict the prognosis of CRC patients. To validate ITGBL1 expression, immunohistochemistry, quantitative real-time PCR and western blotting were performed in CRC tissues and cells...
May 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29770421/quantitative-proteomics-and-systems-analysis-of-cultured-h9c2-cardiomyoblasts-during-differentiation-over-time-supports-a-function-follows-form-model-of-differentiation
#15
Cynthia Kankeu, Kylie Clarke, Delphi Van Haver, Kris Gevaert, Francis Impens, Anna Dittrich, H Llewelyn Roderick, Egle Passante, Heinrich J Huber
The rat cardiomyoblast cell line H9C2 has emerged as a valuable tool for studying cardiac development, mechanisms of disease and toxicology. We present here a rigorous proteomic analysis that monitored the changes in protein expression during differentiation of H9C2 cells into cardiomyocyte-like cells over time. Quantitative mass spectrometry followed by gene ontology (GO) enrichment analysis revealed that early changes in H9C2 differentiation are related to protein pathways of cardiac muscle morphogenesis and sphingolipid synthesis...
May 17, 2018: Molecular omics
https://www.readbyqxmd.com/read/29768548/balance-functional-mobility-and-fall-occurrence-in-patients-with-human-t-cell-lymphotropic-virus-type-1-associated-myelopathy-tropical-spastic-paraparesis-a-cross-sectional-study
#16
Erika Pedreira da Fonseca, Katia Nunes Sá, Rebeca Freitas Reis Nunes, Antônio Carlos Ribeiro Junior, Síntia Freitas Bastos Lira, Elen Beatriz Pinto
INTRODUCTION: Human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) may lead to reduced functional mobility and balance. It is important to establish specific parameters that identify these changes and predict the risk of falls in these patients. The aim was to compare balance, functional mobility, and occurrence of falls among patients with and without HAM/TSP and to suggest values to predict the risk of falls in these patients. METHODS: A cross-sectional study in patients with and without HAM/TSP involved balance assessments based on the berg balance scale (BBS) and functional mobility evaluation based on the timed up and go (TUG) test...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29767227/effect-of-a-balance-training-programme-on-postural-balance-aerobic-capacity-and-frequency-of-falls-in-women-with-osteoporosis-a-randomized-controlled-trial
#17
Ibolya Miko, Imre Szerb, Anna Szerb, Tamas Bender, Gyula Poor
OBJECTIVE: To investigate the effect of a 12-month complex balance-training programme on static and dynamic postural balance, aerobic capacity and frequency of falls in women with established osteoporosis. DESIGN: Randomized controlled trial in which the intervention group was assigned a 12-month exercise programme (3 times a week for 30 min) and the control group had no intervention. SUBJECTS: A total of 100 osteoporotic women with at least one previous fracture...
May 16, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29767225/effect-of-balance-training-on-the-falling-in-osteoporosis-patients-a-systematic-review-and-meta-analysis
#18
Xin Zhou, Hui Ding, Xiaoping Shen, Zingliang Lei
BACKGROUND: Balance training may be beneficial for patients with osteoporosis, although current results are inconclusive. The aim of this systematic review and meta-analysis was to explore the effect of balance training on falls in patients with osteoporosis. METHODS: PubMed, Embase, Web of Science, EBSCO, and Cochrane Library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of balance training vs usual activities on falls in patients with osteoporosis were included...
May 16, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29765348/numerical-affordance-influences-action-execution-a-kinematic-study-of-finger-movement
#19
Rosa Rugani, Sonia Betti, Luisa Sartori
Humans represent symbolic numbers as oriented from left to right: the mental number line (MNL). Up to now, scientific studies have mainly investigated the MNL by means of response times. However, the existing knowledge on the MNL can be advantaged by studies on motor patterns while responding to a number. Cognitive representations, in fact, cannot be fully understood without considering their impact on actions. Here we investigated whether a motor response can be influenced by number processing. Participants seated in front of a little soccer goal...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29765180/effects-of-circular-gait-training-on-balance-balance-confidence-in-patients-with-stroke-a-pilot-study
#20
Shin-Kyu Park, Sung-Jin Kim, Tak Yong Yoon, Suk-Min Lee
[Purpose] This study aimed to investigate the effects of circular gait training on balance and balance confidence in patients with stroke. [Subjects and Methods] Fifteen patients with stroke were randomly divided into either the circular gait training (CGT) group (n=8) or the straight gait training (SGT) group (n=7). Both groups had conventional therapy that adhered to the neurodevelopmental treatment (NDT) approach, for 30 min. In addition, the CGT group performed circular gait training, and the SGT group practiced straight gait training for 30 min...
May 2018: Journal of Physical Therapy Science
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