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https://www.readbyqxmd.com/read/28716231/measuring-standing-balance-in-multiple-sclerosis-further-progress-towards-an-automatic-and-reliable-method-in-clinical-practice
#1
Philipp M Keune, William R Young, Ioannis T Paraskevopoulos, Sascha Hansen, Jana Muenssinger, Patrick Oschmann, Roy Müller
BACKGROUND: Balance deficits in multiple sclerosis (MS) are often monitored by means of observer-rated tests. These may provide reliable data, but may also be time-consuming, subject to inter-rater variability, and potentially insensitive to mild fluctuations throughout the clinical course. On the other hand, laboratory assessments are often not available. The Nintendo Wii Balance Board (WBB) may represent a low-cost solution. The purpose of the current study was to examine the methodological quality of WBB data in MS (internal consistency, test-retest reliability), convergent validity with observer-rated tests (Berg Balance Scale, BBS; Timed-Up and Go Test, TUG), and discriminative validity concerning clinical status (Expanded Disability Status Scale, EDSS)...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28715287/outcome-measures-correlated-with-falls-in-nursing-home-residents-a-pilot-study
#2
Heidi S Moyer, Jeffrey Gale, Stephen Severe, Heather J Braden, Scott Hasson
Most fall risk and normal values are collected from the community-dwelling population, which is not representative of nursing home residents. The purpose of this study was twofold: 1) to determine the relationship of clinical impairment and activity limitation variables to the number of falls in nursing home residents; and 2) to determine the amount of variability that can be explained for the number of falls from these predictor variables. Seventeen active nursing home residents (83.7 ± 11.7 years) consented to participate...
July 17, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28715271/comparison-of-trunk-impairment-scale-versions-1-0-and-2-0-in-people-with-multiple-sclerosis-a-validation-study
#3
Ylva Nilsagård, Anna Carling, Oskar Davidsson, Lisbeth Franzén, Anette Forsberg
BACKGROUND: Trunk control impairment often accompanies multiple sclerosis (MS). Trunk stability is necessary for movements of extremities, as are selective trunk movements for normal gait. Measuring trunk function is thus of interest. METHODS: We examined the relationships between the Trunk Impairment Scale (TIS1.0 and TIS2.0) and the Berg Balance Scale (BBS), 5 sit-to-stand test (5STS), Timed Up and Go test (TUG), 10-m timed walk test (10TW), 2-min walk test (2MWT), Falls Efficacy Scale - International, and 12-item MS Walking Scale (MSWS-12) in 47 outpatients...
July 17, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28715201/rational-design-of-s-uio-66-go-hybrid-nanosheets-for-proton-exchange-membranes-with-significantly-enhanced-transport-performance
#4
Huazhen Sun, Beibei Tang, Peiyi Wu
Metal-organic frameworks (MOFs) are being intensively explored as filler materials for polymeric proton exchange membranes (PEMs) due to their potentials for the systematic design and modification of proton-conducting properties. S-UiO-66, a stable MOF with functional groups of -SO3H in its ligands, was selected here to prepare S-UiO-66@graphene oxide (GO) hybrid nanosheets via facile in situ growth procedure, and then a series of composite PEMs were prepared by hybridizing S-UiO-66@GO and sulfonated poly(ether ether ketone) (SPEEK)...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28713255/the-impact-of-aerobic-exercise-on-fronto-parietal-network-connectivity-and-its-relation-to-mobility-an-exploratory-analysis-of-a-6-month-randomized-controlled-trial
#5
Chun L Hsu, John R Best, Shirley Wang, Michelle W Voss, Robin G Y Hsiung, Michelle Munkacsy, Winnie Cheung, Todd C Handy, Teresa Liu-Ambrose
Impaired mobility is a major concern for older adults and has significant consequences. While the widely accepted belief is that improved physical function underlies the effectiveness of targeted exercise training in improving mobility and reducing falls, recent evidence suggests cognitive and neural benefits gained through exercise may also play an important role in promoting mobility. However, the underlying neural mechanisms of this relationship are currently unclear. Thus, we hypothesize that 6 months of progressive aerobic exercise training would alter frontoparietal network (FPN) connectivity during a motor task among older adults with mild subcortical ischemic vascular cognitive impairment (SIVCI)-and exercise-induced changes in FPN connectivity would correlate with changes in mobility...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28713174/fusing-multiple-neuroimaging-modalities-to-assess-group-differences-in-perception-action-coupling
#6
Jordan Muraskin, Jason Sherwin, Gregory Lieberman, Javier O Garcia, Timothy Verstynen, Jean M Vettel, Paul Sajda
In the last few decades, non-invasive neuroimaging has revealed macro-scale brain dynamics that underlie perception, cognition and action. Advances in non-invasive neuroimaging target two capabilities; 1) increased spatial and temporal resolution of measured neural activity, and 2) innovative methodologies to extract brain-behavior relationships from evolving neuroimaging technology. We target the second. Our novel methodology integrated three neuroimaging methodologies and elucidated expertise-dependent differences in functional (fused EEG-fMRI) and structural (dMRI) brain networks for a perception-action coupling task...
January 2017: Proceedings of the IEEE
https://www.readbyqxmd.com/read/28710329/open-label-trial-of-ranolazine-for-the-treatment-of-myotonia-congenita
#7
W David Arnold, David Kline, Alan Sanderson, Ahmed A Hawash, Amy Bartlett, Kevin R Novak, Mark M Rich, John T Kissel
OBJECTIVE: To determine open-label, pilot study whether ranolazine could improve signs and symptoms of myotonia and muscle stiffness in patients with myotonia congenita (MC). METHODS: Thirteen participants were assessed at baseline and 2, 4, and 5 weeks. Ranolazine was started after baseline assessment (500 mg twice daily), increased as tolerated after week 2 (1,000 mg twice daily), and maintained until week 4. Outcomes included change from baseline to week 4 in self-reported severity of symptoms (stiffness, weakness, and pain), Timed Up and Go (TUG), hand grip and eyelid myotonia, and myotonia on EMG...
July 14, 2017: Neurology
https://www.readbyqxmd.com/read/28709613/a-regional-registry-study-of-216-patients-investigating-if-patient-satisfaction-after-total-knee-arthroplasty-changes-over-a-time-period-of-five-to-20years
#8
Odei Shannak, Jeya Palan, Colin Esler
AIMS: To determine the temporal changes in patient dissatisfaction following primary knee arthroplasty surgery (TKA). PATIENTS AND METHODS: Three hundred and ninety patients that had previously indicated they were either dissatisfied or unsure with their TKA at one-year post-surgery in our region were mailed a simple questionnaire in addition to the Oxford Knee Score and EQ-5D. RESULTS: A 55% response rate was achieved. The mean follow-up time period was 9...
August 2017: Knee
https://www.readbyqxmd.com/read/28706105/how-people-with-dementia-and-carers-understand-and-react-to-social-functioning-changes-in-mild-dementia-a-uk-based-qualitative-study
#9
David Singleton, Naaheed Mukadam, Gill Livingston, Andrew Sommerlad
OBJECTIVES: To analyse people with dementia and their family carers' attribution of social changes in dementia and the consequences of these attributions. DESIGN: Qualitative study, using a semi-structured interview guide. Individual interviews continued to theoretical saturation. Two researchers independently analysed interview transcripts. SETTING AND PARTICIPANTS: People with mild dementia and family carers purposively selected from London-based memory services for diverse demographic characteristics to encompass a range of experiences...
July 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28702448/study-of-gait-using-weighted-vests-on-balance-with-paraplegic-patients
#10
Hyuk-Jae Choi, Hyun-Joo Kang
The aims of this study were to identify static and dynamic balance with the addition of weighted vests for the rehabilitation of paraplegic patients. The study was conducted using weighted vest exercises with applied optimal weight ratios. Ten paraplegic patients who use custom orthosis were enrolled for experiments including static standing and dynamic gait with a weighted vest. We set weight ratios as 0%, 10%, and 15% of the patients' weight. A plantar pressure device was used for static balance tests for excursion and velocity of center of pressure and we identified dynamic balance through the tool of Timed Up and Go (TUG) test...
June 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28702443/physical-exercise-programs-at-basic-healthcare-units-decrease-body-fat-and-improve-the-functional-capacity-of-women-over-50-years-old
#11
Fabrício Eduardo Rossi, Anderson Rogério Lecca, Luiz Gustavo Perón Martins, Luciana Sanae Ota Takahashi, Diego Giuliano Destro Christofaro, Luís Alberto Gobbo, Ismael F Freitas
This study verified the effects of a physical exercise program performed at Basic Healthcare Units on the body composition and functional capacity of women over 50 years old and to compare these variables according to age. Forty-eight women (age, 65.4±7.3 years) were assessed. The program lasted 20 weeks, and was conducted 2 times per week, 60 min/day. Body mass and height were collected and body mass index (BMI) was calculated. Bioelectrical impedance was used to estimate fat mass and fat free mass. Functional capacities: handgrip test, Timed Up and Go (TUG) test, and Guralnick test were assessment...
June 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28700731/forward-flexion-of-trunk-in-parkinson-s-disease-patients-is-affected-by-subjective-vertical-position
#12
Kyohei Mikami, Makoto Shiraishi, Tsubasa Kawasaki, Tsutomu Kamo
PURPOSE: No method has been established to evaluate the dissociation between subjective and objective vertical positions with respect to the self-awareness of postural deformity in patients with Parkinson's disease (PD). The purpose of this study was to demonstrate, from the relationship between an assessment of the dissociation of subjective and objective vertical positions of PD patients and an assessment based on established PD clinical evaluation scales, that the dissociation regarding vertical position is a factor in the severity of the forward flexion of trunk (FFT)...
2017: PloS One
https://www.readbyqxmd.com/read/28698105/magnetic-resonance-imaging-mri-defined-cartilage-degeneration-and-joint-pain-are-associated-with-poor-physical-function-in-knee-osteoarthritis-the-oulu-knee-osteoarthritis-study
#13
Päivi Kaukinen, Jana Podlipská, Ali Guermazi, Jaakko Niinimäki, Petri Lehenkari, Frank W Roemer, Miika T Nieminen, Juhani M Koski, Simo Saarakkala, Jari Pa Arokoski
OBJECTIVE: The main aim was to investigate the associations between MRI-defined structural pathologies of the knee and physical function. DESIGN: A cohort study with frequency matching on age and sex with eighty symptomatic subjects with knee pain and suspicion or diagnosis of knee osteoarthritis (OA) and 57 asymptomatic subjects was conducted. The subjects underwent knee MRI, and the severity of structural changes was graded by MRI Osteoarthritis Knee Score (MOAKS) in separate knee locations...
July 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28690473/total-knee-arthroplasty-for-knee-osteoarthritis-support-for-a-foregone-conclusion
#14
REVIEW
Michael E Steinhaus, Alexander B Christ, Michael B Cross
Total knee arthroplasty (TKA) is generally accepted as the definitive treatment for advanced knee arthritis after patients fail nonoperative treatments; however, the safety and efficacy of TKA compared to continued nonoperative treatment has never been proven in high-quality, randomized controlled trials. Recently, a 2015 Danish study published a 12-month follow-up on a cohort of patients randomized to either a TKA or continued nonsurgical management for advanced knee osteoarthritis (OA). The authors reported significantly greater improvement in the TKA group in functional outcome scores such as the overall Knee Injury and Osteoarthritis Outcome Score (KOOS4 score), the KOOS subscales, EQ-5D descriptive index, and timed get up-and-go and 20-m walk tests; however, patients in the TKA did suffer significantly more serious adverse events (SAE)...
July 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28689874/shortening-the-incubation-time-for-the-combination-disk-diffusion-esbl-confirmation-test-how-far-can-we-go
#15
Wouter van den Bijllaardt, Patricia C M Voermans, Anton G Buiting, Johan W Mouton, Anouk E Muller
The combination disk-diffusion ESBL confirmation test (CDT) is used for the confirmation of ESBL production in Enterobacteriaceae and usually takes 16-20 hours to results. We searched for the shortest possible incubation time without reduction in reliability. A total of 125 ESBL screening positive isolates were subjected to CDT and molecularly characterized by microarray. Inhibition zones were read every hour over 6-18 hours of incubation. Concordance between earlier and 18 hour reading was calculated for each hour...
July 6, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28689306/targeted-spine-strengthening-exercise-and-posture-training-program-to-reduce-hyperkyphosis-in-older-adults-results-from-the-study-of-hyperkyphosis-exercise-and-function-sheaf-randomized-controlled-trial
#16
W B Katzman, E Vittinghoff, F Lin, A Schafer, R K Long, S Wong, A Gladin, B Fan, B Allaire, D M Kado, N E Lane
A 6-month randomized controlled trial of spine-strengthening exercise and posture training reduced both radiographic and clinical measures of kyphosis. Participants receiving the intervention improved self-image and satisfaction with their appearance. Results suggest that spine-strengthening exercise and postural training may be an effective treatment option for older adults with hyperkyphosis. INTRODUCTION: The purpose of the present study is to determine in a randomized controlled trial whether spine-strengthening exercises improve Cobb angle of kyphosis in community-dwelling older adults...
July 8, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28685471/gold-nanoparticle-based-fluorescent-contrast-agent-with-enhanced-sensitivity
#17
Kyung Aih Kang, Mai-Dung Nguyen
Gold nanoparticle (GNP) based contrast agents that are highly specific and sensitive for both optical and X-ray/CT imaging modalities are being developed for detecting the cancer expressing nucleolin and matrix metallo-proteinase 14 (MMP-14) on the cell membrane: Nucleolin is normally present in the nucleus. For many cancer cells, however, it is over-expressed on the cell membrane, having it to be a good cancer marker. Aptamer AS1411 is known to be an excellent target for nucleolin and also known to treat several cancer types; and MMP-14 in cancer is involved in tumor angiogenesis, blood vessel re-organization, and metastasis...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28685450/effects-of-motor-imagery-on-cognitive-function-and-prefrontal-cortex-activity-in-normal-adults-evaluated-by-nirs
#18
M Moriya, K Sakatani
Recent near-infrared spectroscopy (NIRS) studies demonstrated that physical exercise enhances working memory (WM) performance and prefrontal cortex (PFC) activity during WM tasks in normal adults. Interestingly, the effects of rehabilitation (i.e. physiotherapy) on post-stroke patients could be enhanced by motor imagery (MI), an active process during which the specified action is reproduced within WM without any actual physical movement. However, it is not known whether MI can enhance cognitive function and associated brain activity...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28684703/western-and-mediterranean-dietary-patterns-and-physical-activity-and-fitness-among-spanish-older-adults
#19
Maria Del Mar Bibiloni, Alicia Julibert, Emma Argelich, Raquel Aparicio-Ugarriza, Gonzalo Palacios, Antoni Pons, Marcela Gonzalez-Gross, Josep A Tur
Objectives: To assess prevailing food patterns, and its association with physical activity and fitness among Spanish older adults. Methods: Cross-sectional study in Spain, collecting data from a sample (n = 380; 54% female) aged 55-80 years (men) and 60-80 years (women) with no previously documented cardiovascular disease. Body weight, body fat and waist circumference were assessed. Physical activity performed was measured using the Minnesota Leisure-time Physical Activity Questionnaire (LTPA). Physical fitness was assessed using a validated physical fitness test battery...
July 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28683150/hospitalization-and-rehospitalization-in-parkinson-disease-patients-data-from-the-national-parkinson-foundation-centers-of-excellence
#20
Leili Shahgholi, Sol De Jesus, Samuel S Wu, Qinglin Pei, Anhar Hassan, Melissa J Armstrong, Daniel Martinez-Ramirez, Peter Schmidt, Michael S Okun
BACKGROUND: Patients with Parkinson disease (PD) are at high risk of hospital encounters with increasing morbidity and mortality. This study aimed to determine the rate of hospital encounters in a cohort followed over 5 years and to identify associated factors. METHODS: We queried the data from the International Multicenter National Parkinson Foundation Quality Improvement study. Multivariate logistic regression with backward selection was performed to identify factors associated with hospital encounter prior to baseline visit...
2017: PloS One
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