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https://www.readbyqxmd.com/read/29331870/postural-instability-differences-between-idiopathic-normal-pressure-hydrocephalus-and-parkinson-s-disease
#1
Yasutaka Nikaido, Toshihiro Akisue, Yoshinaga Kajimoto, Adam Tucker, Yuki Kawami, Hideyuki Urakami, Yuka Iwai, Hisatomo Sato, Tadayuki Nishiguchi, Tetsuya Hinoshita, Kenji Kuroda, Hiroshi Ohno, Ryuichi Saura
OBJECTIVES: We investigated the differences in postural control disability between idiopathic normal pressure hydrocephalus (iNPH) and Parkinson's disease (PD). PATIENTS AND METHODS: Twenty-seven iNPH patients, 20 PD patients, and 20 healthy controls (HCs) were examined using the Timed Up and Go test (TUG) and a force platform for recording the center of pressure (COP) trajectory during quiescent standing and voluntary multidirectional leaning (forward, backward, right, and left for 10 s each)...
January 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29330399/geriatric-assessment-and-quality-of-life-in-older-patients-considered-for-allogeneic-hematopoietic-cell-transplantation-a-prospective-risk-factor-and-serial-assessment-analysis
#2
Barbara Deschler, Gabriele Ihorst, Susanne Schnitzler, Hartmut Bertz, Juergen Finke
Allogeneic hematopoietic cell transplantation (alloHCT) in older patients requires the weighing of risks and benefits for this potentially curative treatment while facing age-related limitations. Comprehensive geriatric and quality of life (EORTC QLQ C-30) assessements (CGA/QOL) in addition to disease-specific data were obtained in 108 consecutive patients (≥60 years) pre-HCT, at day +30, +100, and +180. Median follow-up of 106 patients alive at alloHCT was 43.5 months, median age 66 years (range 60-78). Eighty-six (81...
January 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29330370/a-rna-sequencing-approach-for-the-identification-of-novel-long-non-coding-rna-biomarkers-in-colorectal-cancer
#3
Atsushi Yamada, Pingjian Yu, Wei Lin, Yoshinaga Okugawa, C Richard Boland, Ajay Goel
Long non-coding RNAs (lncRNAs) have been implicated in human pathology, however, their role in colorectal carcinogenesis have not been fully elucidated. In the current study, whole-transcriptome analysis was performed in 3 pairs of colorectal cancer (CRC) and matched normal mucosa (NM) by RNA sequencing (RNA-seq). Followed by confirmation using the Cancer Genome Atlas (TCGA) dataset, we identified 27 up-regulated and 22 down-regulated lncRNAs in CRC. Up-regulation of four lncRNAs, hereby named colorectal cancer associated lncRNA (CRCAL)-1 [AC021218...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329973/altered-gene-expression-in-tree-shrew-retina-and-retinal-pigment-epithelium-produced-by-short-periods-of-minus-lens-wear
#4
Li He, Michael R Frost, John T Siegwart, Thomas T Norton
Hyperopic refractive error is detected by retinal neurons, which generate GO signals through a direct emmetropization signaling cascade: retinal pigment epithelium (RPE) into choroid and then into sclera, thereby increasing axial elongation. To examine signaling early in this cascade, we measured gene expression in the retina and RPE after short exposure to hyperopia produced by minus-lens wear. Gene expression in each tissue was compared with gene expression in combined retina + RPE. Starting 24 days after normal eye opening, three groups of juvenile tree shrews (n = 7 each) wore a monocular -5 D lens...
January 9, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29326098/cognitive-and-behavioral-skills-exercises-completed-by-patients-with-major-depression-during-smartphone-cognitive-behavioral-therapy-secondary-analysis-of-a-randomized-controlled-trial
#5
Toshi A Furukawa, Masaru Horikoshi, Hirokazu Fujita, Naohisa Tsujino, Ran Jinnin, Yuki Kako, Sei Ogawa, Hirotoshi Sato, Nobuki Kitagawa, Yoshihiro Shinagawa, Yoshio Ikeda, Hissei Imai, Aran Tajika, Yusuke Ogawa, Tatsuo Akechi, Mitsuhiko Yamada, Shinji Shimodera, Norio Watanabe, Masatoshi Inagaki, Akio Hasegawa
BACKGROUND: A strong and growing body of evidence has demonstrated the effectiveness of cognitive behavioral therapy (CBT), either face-to-face, in person, or as self-help via the Internet, for depression. However, CBT is a complex intervention consisting of several putatively effective components, and how each component may or may not contribute to the overall effectiveness of CBT is poorly understood. OBJECTIVE: The aim of this study was to investigate how the users of smartphone CBT use and benefit from various components of the program...
January 11, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29326087/a-multicomponent-exercise-program-improves-physical-function-in-long-term-nursing-home-residents-a-randomized-controlled-trial
#6
Haritz Arrieta, Chloe Rezola, Idoia Zarrazquin, Iñaki Echeverria, Jose Javier Yanguas, Miren Iturburu, Susana Maria Gil, Ana Rodriguez-Larrad, Jon Irazusta
To investigate the impact of a multicomponent exercise program on anthropometry, physical function, and physical activity on older adults living in long-term nursing homes (LTNH), we conducted a randomized controlled trial involving 112 participants aged 84.9 ± 6.9 years. Participants were randomly assigned to an intervention (IG) or control group (CG). The IG participated in a 3-month multicomponent exercise intervention focused on strength, balance, stretching exercises, and walking recommendations...
January 8, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29325794/association-of-posture-and-ambulation-with-function-at-30-days-post-hospital-discharge-in-older-adults-with-heart-failure
#7
Theresa A Floegel, Jared M Dickinson, Cheryl DerAnanian, Marianne McCarthy, Steven P Hooker, Matthew P Buman
PURPOSE: To investigate the predictive value of in-hospital posture and ambulatory activity for 30-d following discharge on functional status in older patients with heart failure. METHODS: Prospective observational pilot study of 27 patients (78 ± 9.8yrs; 51.8% female) admitted with heart failure. Participants wore two inclinometric accelerometers to record posture in-hospital, and an ankle accelerometer to record ambulatory activity in-hospital and 30 days after discharge...
January 8, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29322927/cpredictor3-0-detecting-protein-complexes-from-ppi-networks-with-expression-data-and-functional-annotations
#8
Ying Xu, Jiaogen Zhou, Shuigeng Zhou, Jihong Guan
BACKGROUND: Effectively predicting protein complexes not only helps to understand the structures and functions of proteins and their complexes, but also is useful for diagnosing disease and developing new drugs. Up to now, many methods have been developed to detect complexes by mining dense subgraphs from static protein-protein interaction (PPI) networks, while ignoring the value of other biological information and the dynamic properties of cellular systems. RESULTS: In this paper, based on our previous works CPredictor and CPredictor2...
December 21, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29318933/comparing-auditory-visual-and-vibrotactile-cues-in-individuals-with-parkinson-s-disease-for-reducing-risk-of-falling-over-different-types-of-soil
#9
Johannes C Ayena, Louis E Tremblay, Martin J-D Otis, Bob-Antoine J Ménélas
INTRODUCTION: Several researchers have demonstrated the positive benefits of auditory and visual cueing in the gait improvements among individuals with Parkinson's disease (PD). However, few studies have evaluated the role of vibrotactile cueing when compared to auditory and visual cueing. This paper compares how these stimuli affect the risk of falling while walking on six types of soil (concrete, sand, parquet, broken stone, two types of carpet). METHODS: An instrumented Timed Up and Go (iTUG) test served to evaluate how audio, visual and vibrotactile cueing can affect the risk of falling of elderly...
January 10, 2018: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/29318171/mobile-web-based-follow-up-for-postoperative-acl-reconstruction-a-single-center-experience
#10
James Higgins, John Semple, Lucas Murnaghan, Sarah Sharpe, John Theodoropoulos
Background: The initial 6 weeks after surgery has been identified as an area for improvement in patient care. During this period, the persistence of symptoms that go unchecked can lead to unscheduled emergency room and clinic visits, calls to surgeons' offices, and readmissions. Purpose: To analyze postoperative data from a previous study examining postoperative outcomes in 2 patient populations following breast reconstruction and anterior cruciate ligament (ACL) reconstruction with use of a patient-centered mobile application...
December 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29317222/do-performance-measures-of-strength-balance-and-mobility-predict-quality-of-life-and-community-reintegration-after-stroke
#11
Joshua W Cohen, Tanya D Ivanova, Brenda Brouwer, Kimberly J Miller, Dianne Bryant, S Jayne Garland
OBJECTIVE: To investigate the extent to which physical performance measures of strength, balance and mobility taken at discharge from inpatient stroke rehabilitation can predict health-related quality of life (HRQoL) and community reintegration after 6 months. DESIGN: Longitudinal Study SETTING: University Laboratory PARTICIPANTS: Seventy-five adults recruited within one month following discharge home from inpatient stroke rehabilitation. Inclusion criteria were: major unilateral hemispheric stroke, English speaking, able to communicate, discharged home...
January 6, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29315129/relative-contributions-of-adductor-canal-block-and-intrathecal-morphine-to-analgesia-and-functional-recovery-after-total-knee-arthroplasty-a-randomized-controlled-trial
#12
Abhijit Biswas, Anahi Perlas, Meela Ghosh, KiJinn Chin, Ahtsham Niazi, Barjind Pandher, Vincent Chan
BACKGROUND AND OBJECTIVES: Effective postoperative analgesia may enhance early rehabilitation after orthopedic surgery. This randomized double-blind trial investigates the relative contributions of adductor canal block and low-dose intrathecal morphine (ITM) to postoperative analgesia and functional recovery after total knee arthroplasty. METHODS: Two-hundred one patients undergoing elective unilateral total knee arthroplasty under spinal anesthesia were randomized to 3 groups...
January 9, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29314249/functional-performances-on-admission-predict-in-hospital-falls-injurious-falls-and-fractures-in-older-patients-a-prospective-study
#13
Mélany Hars, Marie-Claude Audet, François Herrmann, Jean De Chassey, René Rizzoli, Jean-Luc Reny, Gabriel Gold, Serge Ferrari, Andrea Trombetti
Falls are common among older inpatients, and remain a great challenge for hospitals. Despite the relevance of physical impairments to falls, the prognostic value of performance-based functional measures for in-hospital falls and injurious falls remains unknown. This study aimed to determine the predictive ability and accuracy of various functional tests administered at or close to admission in a geriatric hospital to identify in-hospital fallers and injurious fallers. In this prospective study, conducted in a geriatric hospital in Geneva (Switzerland), 807 inpatients (mean age, 85...
January 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29304248/viable-acrosome-intact-human-spermatozoa-in-the-ejaculate-as-a-marker-of-semen-quality-and-fertility-status
#14
Dorte Louise Egeberg Palme, Anders Rehfeld, Anne Kirstine Bang, Kristiana Alexandrova Nikolova, Søren Kjærulff, Morten Rønn Petersen, Janni Vikkelsø Jeppesen, Martin Glensbjerg, Anders Juul, Niels E Skakkebæk, Søren Ziebe, Niels Jørgensen, Kristian Almstrup
STUDY QUESTION: Is it possible, in an unbiased and clinical relevant way, to determine the number of viable acrosome-intact human spermatozoa in ejaculates and to use this as a measure of fertility chances? SUMMARY ANSWER: Image cytometry enables easy and unbiased quantification of viable acrosome-intact spermatozoa and it correlates with semen quality and fertility status. WHAT IS KNOWN ALREADY: The presence of the acrosome and its ability to respond to physiological inducers (e...
January 2, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29301322/search-methods-used-to-locate-missing-cats-and-locations-where-missing-cats-are-found
#15
Liyan Huang, Marcia Coradini, Jacquie Rand, John Morton, Kat Albrecht, Brigid Wasson, Danielle Robertson
Missing pet cats are often not found by their owners, with many being euthanized at shelters. This study aimed to describe times that lost cats were missing for, search methods associated with their recovery, locations where found and distances travelled. A retrospective case series was conducted where self-selected participants whose cat had gone missing provided data in an online questionnaire. Of the 1210 study cats, only 61% were found within one year, with 34% recovered alive by the owner within 7 days...
January 2, 2018: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29300423/effects-of-low-dose-dairy-protein-plus-micronutrient-supplementation-during-resistance-exercise-on-muscle-mass-and-physical-performance-in-older-adults-a-randomized-controlled-trial
#16
S Seino, K Sumi, M Narita, Y Yokoyama, K Ashida, A Kitamura, S Shinkai
OBJECTIVES: To investigate whether supplementation with low-dose dairy protein plus micronutrients augments the effects of resistance exercise (RE) on muscle mass and physical performance compared with RE alone among older adults. DESIGN: Randomized controlled trial. SETTING: Tokyo, Japan. PARTICIPANTS: Eighty-two community-dwelling older adults (mean age, 73.5 years) were randomly allocated to an RE plus dairy protein and micronutrient supplementation group or an RE only group (n = 41 each)...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29300250/postoperative-disability-after-long-corrective-fusion-to-the-pelvis-in-elderly-patients-with-spinal-deformity
#17
Daisuke Togawa, Tomohiko Hasegawa, Yu Yamato, Go Yoshida, Sho Kobayashi, Tatsuya Yasuda, Shin Oe, Tomohiro Banno, Hideyuki Arima, Yuki Mihara, Hiroki Ushirozako, Yukihiro Matsuyama
STUDY DESIGN: Prospective case series analysis. OBJECTIVE: The purpose of this study was to investigate the degree of difficulty in daily activities of adult spinal deformity (ASD) patients after corrective long fusion to the pelvis, with emphasis on bend forward activities. SUMMARY OF BACKGROUND DATA: No prospective studies have been reported regarding the postoperative impairments and their time course after long fusion in ASD patients. METHODS: One-hundred-three patients (26 men, 77 women; mean age 68 [50-82]) who underwent corrective long fusion from the thoracic spine to the pelvis were included...
January 3, 2018: Spine
https://www.readbyqxmd.com/read/29298237/elevated-high-sensitivity-troponin-i-during-living-donor-liver-transplantation-is-associated-with-postoperative-adverse-outcomes
#18
Jungchan Park, Seung Hwa Lee, Sangbin Han, Ki Yoon Kim, Go Eun Kim, Myungsoo Park, Suk-Koo Lee, Gyu-Seong Choi, Soohyun Ahn, Hyeon Seon Ahn, Gaab Soo Kim
BACKGROUND: This study aimed to evaluate risk factors and postoperative clinical outcome associated with myocardial injury detected by an elevated high-sensitivity cardiac troponin I (hs-cTnI) immediately after living donor liver transplantation (LDLT). METHODS: Between January 2011 and December 2016, 313 adult recipients undergoing LDLT, with normal preoperative hs-cTnI were selected. Hs-cTnI level above 0.04 ng/mL according to 99th percentile reference limit was defined as myocardial injury...
January 2, 2018: Transplantation
https://www.readbyqxmd.com/read/29291566/going-with-the-flow-planktonic-processing-of-dissolved-organic-carbon-in-streams
#19
Daniel Graeber, Jane Rosenstand Poulsen, Marlen Heinz, Jes J Rasmussen, Dominik Zak, Björn Gücker, Brian Kronvang, Norbert Kamjunke
A large part of the organic carbon in streams is transported by pulses of terrestrial dissolved organic carbon (tDOC) during hydrological events, which is more pronounced in agricultural catchments due to their hydrological flashiness. The majority of the literature considers stationary benthic biofilms and hyporheic biofilms to dominate uptake and processing of tDOC. Here, we argue for expanding this viewpoint to planktonic bacteria, which are transported downstream together with tDOC pulses, and thus perceive them as a less variable resource relative to stationary benthic bacteria...
December 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29291553/a-novel-ion-imprinted-polymer-based-on-graphene-oxide-mesoporous-silica-nanosheet-for-fast-and-efficient-removal-of-chromium-vi-from-aqueous-solution
#20
Renfeng Huang, Xiaoguo Ma, Xin Li, Lihui Guo, Xiaowen Xie, Menyuan Zhang, Jing Li
A novel chromium (VI) ion-imprinted polymer (Cr(VI)-IIP) was prepared using surface ion imprinting technique on graphene oxide-mesoporous silica (GO-MS) nanosheets with 3-(2-amino ethyl amino) propyl trimethoxysilane as the functional monomer. The prepared Cr(VI)-IIP was characterized by Fourier transform infrared spectroscopy, scanning electronic microscopy, X-ray diffraction and thermogravimetric analysis. The prepared Cr(VI)-IIP was then applied to remove Cr(VI) ions from aqueous solution. The influences of functional monomer amount, contact time, initial Cr(VI) concentration, solution pH and temperature, on the adsorption performance of Cr(VI)-IIP were investigated...
December 26, 2017: Journal of Colloid and Interface Science
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