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JOURNAL ARTICLE
Frederik Novak, Hamza Mahmood Bajwa, Kamilla Østergaard, Jonas Munksgaard Berg, Jonna Skov Madsen, Dorte Aalund Olsen, Inga Urbonaviciute, Zsolt Illes, Morten Leif Stilund, Jeppe Romme Christensen, Stephan Bramow, Finn Sellebjerg, Tobias Sejbaek
BACKGROUND: This study investigates clinical and biomarker differences between standard interval dosing (SID) and extended interval dosing (EID) of ocrelizumab therapy in multiple sclerosis (MS). METHODS: This is a prospective, double-arm, open-label, multi-center study in Denmark. Participants diagnosed with MS on ocrelizumab therapy >12 months were included ( n = 184). Clinical, radiological, and blood-based biomarker outcomes were evaluated. MRI disease activity, relapses, worsening of neurostatus, and No Evidence of Disease Activity-3 (NEDA-3) were used as a combined endpoint...
April 22, 2024: Multiple Sclerosis: Clinical and Laboratory Research
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JOURNAL ARTICLE
Sam De Waegenaere, Monica van den Berg, Georgios A Keliris, Mohit H Adhikari, Marleen Verhoye
INTRODUCTION: Alzheimer's disease (AD) is a progressive neurodegenerative disease resulting in memory loss and cognitive decline. Synaptic dysfunction is an early hallmark of the disease whose effects on whole-brain functional architecture can be identified using resting-state functional MRI (rsfMRI). Insights into mechanisms of early, whole-brain network alterations can help our understanding of the functional impact of AD's pathophysiology. METHODS: Here, we obtained rsfMRI data in the TgF344-AD rat model at the pre- and early-plaque stages...
2024: Frontiers in Human Neuroscience
#3
JOURNAL ARTICLE
Giorgio Bottoni, Oscar Crisafulli, Caterina Pisegna, Marco Serra, Sara Brambilla, Fausto Feletti, Giovanni Cremonte, Giuseppe D'Antona
BACKGROUND: It is unclear whether prolonged periods of training can be well tolerated. In Charcot-Marie Tooth disease (CMT). We report the effects of an 8-month, adapted motor activity (AMA) program in a 16-years-old CMT1A male patient. The program included strength, mobility, and balance training (two sessions per week, 1 h per session). MEASURES: Walking ability and walking velocity (Six-Minute Walking Test-6MWT, Ten Meters Walking Test-10 mW T), balance (Y-Balance Test-YBT, Berg Balance Scale-BBS), functional mobility (Short Physical Performance Battery-Short physical performance battery), fatigue (Checklist Individual strength questionnaire - CIS20R), health and quality of life (Short Form Health Survey 36 questionnaire-SF-36) were evaluated in three moments: before (T0), after 5 (T1) and 8 (T2) months of adapted motor activity...
2024: Frontiers in Physiology
#4
JOURNAL ARTICLE
A D Tate, A Trofholz, A Youngblood, A B Goldschmidt, J M Berge
The resource depletion model proposes that self-control is a limited resource that may become depleted after repeated use. This study aimed to improve our understanding of the correlates of resource depletion in parents, examine the association between resource depletion and use of coercive food parenting practices, and explore the relationship between resource depletion and stress. Children aged 5-9 and their parents (n=631 dyads) were recruited from primary care clinics in a large metropolitan area in the United States in 2016-2019...
April 19, 2024: Appetite
#5
REVIEW
Jane Carter Ingram, Emily J McKenzie, Kenneth J Bagstad, John Finisdore, Rayne van den Berg, Eli Fenichel, Michael Vardon, Stephen Posner, Marta Santamaria, Lisa Mandle, Richard Barker, James Spurgeon
Nature loss threatens businesses, the global economy and financial stability. Understanding and addressing these risks for business will require credible measurement approaches and data. This paper explores how natural capital accounting (NCA) can support business data and information needs related to nature, including disclosures aligned with the Taskforce on Nature-related Financial Disclosures recommendations. As businesses seek to measure, manage and disclose their nature-related risks and opportunities, they will need well-organized, consistent and high-quality information regarding their dependencies and impacts on nature, which few businesses currently collect or track in-house...
June 10, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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JOURNAL ARTICLE
Mary Jo Fackler, Madison Pleas, Youran Li, Anushri Soni, Deyin Xing, Leslie Cope, Syed Ali, Quang Van Le, Chu Van Nguyen, Han Thi Pham, Long Minh Duong, Eunice Vanden Berg, Reubina Wadee, Pamela Michelow, Wenlong Carl Chen, Maureen Joffe, Christina Saetan Fjeldbo, Heidi Lyng, Saraswati Sukumar
BACKGROUND: Cervical cancer remains a leading cause of death, particularly in developing countries. WHO screening guidelines recommend human papilloma virus (HPV) detection as a means to identify women at risk of developing cervical cancer. While HPV testing identifies those at risk, it does not specifically distinguish individuals with neoplasia. We investigated whether a quantitative molecular test that measures methylated DNA markers could identify high-risk lesions in the cervix with accuracy...
April 20, 2024: Clinical Epigenetics
#7
Nick Shrine, Anna L Guyatt, A Mesut Erzurumluoglu, Victoria E Jackson, Brian D Hobbs, Carl A Melbourne, Chiara Batini, Katherine A Fawcett, Kijoung Song, Phuwanat Sakornsakolpat, Xingnan Li, Ruth Boxall, Nicola F Reeve, Ma'en Obeidat, Jing Hua Zhao, Matthias Wielscher, Stefan Weiss, Katherine A Kentistou, James P Cook, Benjamin B Sun, Jian Zhou, Jennie Hui, Stefan Karrasch, Medea Imboden, Sarah E Harris, Jonathan Marten, Stefan Enroth, Shona M Kerr, Ida Surakka, Veronique Vitart, Terho Lehtimäki, Richard J Allen, Per S Bakke, Terri H Beaty, Eugene R Bleecker, Yohan Bossé, Corry-Anke Brandsma, Zhengming Chen, James D Crapo, John Danesh, Dawn L DeMeo, Frank Dudbridge, Ralf Ewert, Christian Gieger, Amund Gulsvik, Anna L Hansell, Ke Hao, Joshua D Hoffman, John E Hokanson, Georg Homuth, Peter K Joshi, Philippe Joubert, Claudia Langenberg, Xuan Li, Liming Li, Kuang Lin, Lars Lind, Nicholas Locantore, Jian'an Luan, Anubha Mahajan, Joseph C Maranville, Alison Murray, David C Nickle, Richard Packer, Margaret M Parker, Megan L Paynton, David J Porteous, Dmitry Prokopenko, Dandi Qiao, Rajesh Rawal, Heiko Runz, Ian Sayers, Don D Sin, Blair H Smith, María Soler Artigas, David Sparrow, Ruth Tal-Singer, Paul R H J Timmers, Maarten Van den Berge, John C Whittaker, Prescott G Woodruff, Laura M Yerges-Armstrong, Olga G Troyanskaya, Olli T Raitakari, Mika Kähönen, Ozren Polašek, Ulf Gyllensten, Igor Rudan, Ian J Deary, Nicole M Probst-Hensch, Holger Schulz, Alan L James, James F Wilson, Beate Stubbe, Eleftheria Zeggini, Marjo-Riitta Jarvelin, Nick Wareham, Edwin K Silverman, Caroline Hayward, Andrew P Morris, Adam S Butterworth, Robert A Scott, Robin G Walters, Deborah A Meyers, Michael H Cho, David P Strachan, Ian P Hall, Martin D Tobin, Louise V Wain
No abstract text is available yet for this article.
April 19, 2024: Nature Genetics
#8
JOURNAL ARTICLE
Alex S Cornelissen, Roland M van den Berg, Jan P Langenberg, Marco van Grol, Rowdy Bross, John Pittman, Laura Cochrane, Vladimir Savransky
In recent years, various poisoning incidents have been reported, involving the alleged use of the so-called Novichok agents, resulting in their addition to the Schedule I list of the Organisation for the Prohibition of Chemical Warfare (OPCW). As the physicochemical properties of these agents are different from the 'classical' nerve agents, such as VX, research is needed to evaluate whether and to what extent existing countermeasures are effective. Here, we evaluated the therapeutic potential of RSDL® (Reactive Skin Decontamination Lotion Kit) for the neutralization of percutaneous toxicity caused by Novichok agents, both in vitro and in vivo...
April 17, 2024: Chemico-biological Interactions
#9
JOURNAL ARTICLE
Shruthi Venkatesh, Stacey N Doan
Under stress, parents tend to use more controlling feeding behaviors toward their children (Berge et al., 2017; Doan et al., 2022; Loth et al., 2016). However, the majority of prior work focuses on subjective reports of stress, and there is a dearth of research examining parental physiological stress and its impact on feeding behaviors. In the current study, we examined how parental physiological stress reactivity would influence their feeding behaviors under mild stress in a lab-based setting. Parents (n = 83, 50 % females) and their children (59% female, Mage =42 months, SD=4...
April 17, 2024: Appetite
#10
JOURNAL ARTICLE
Tessa S Groen-van Schooten, Micaela Harrasser, Jens Seidel, Emma N Bos, Tania Fleitas, Monique van Mourik, Roos E Pouw, Ruben S A Goedegebuure, Benthe H Doeve, Jasper Sanders, Joris Bos, Mark I van Berge Henegouwen, Victor L J L Thijssen, Nicole C T van Grieken, Hanneke W M van Laarhoven, Tanja D de Gruijl, Sarah Derks
BACKGROUND: Tumors in the distal esophagus (EAC), gastro-esophageal junction including cardia (GEJAC), and stomach (GAC) develop in close proximity and show strong similarities on a molecular and cellular level. However, recent clinical data showed that the effectiveness of chemo-immunotherapy is limited to a subset of GEAC patients and that EACs and GEJACs generally benefit less from checkpoint inhibition compared to GACs. As the composition of the tumor immune microenvironment drives response to (immuno)therapy we here performed a detailed immune analysis of a large series of GEACs to facilitate the development of a more individualized immunomodulatory strategy...
2024: Frontiers in Immunology
#11
JOURNAL ARTICLE
Nancy Lau, Kathleen J Ramos, Moira L Aitken, Christopher H Goss, Krysta S Barton, Erin K Kross, Ruth A Engelberg
BACKGROUND: Although cystic fibrosis (CF) is a progressive, life-limiting, genetic disease, recent advances have extended survival, allowing persons with CF the time and physical and mental health to form romantic relationships. Previous studies have shown the importance of dyadic coping to positive psychosocial functioning and relationship satisfaction for people with serious chronic illness and their romantic partners, but little work has been done with persons with CF and their partners...
April 2024: Journal of Social and Personal Relationships
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JOURNAL ARTICLE
T J Verhoeven, S Vinayahalingam, G Claeys, T Xi, S J Berge, T J J Maal
This study was aimed to assess whether facial asymmetry increases with age and to examine potential gender differences using 3D stereophotogrammetry. A prospective cross-sectional study was performed. 3D photographs were acquired from 600 control subjects, 300 male, 300 female, and were stratified into 15 different age groups ranging from 0 to 70+. The 3D photographs were postprocessed and mirrored. The original and mirrored faces were surface-based matched using an iterative closest point algorithm. The primary outcome variable, facial asymmetry, was evaluated by calculating the absolute mean distance between the original and mirrored images...
April 3, 2024: Journal of Cranio-maxillo-facial Surgery
#13
EDITORIAL
Simon Nørskov Thomsen, Alejandro Lucia, Rosalind R Spence, Fabiana Braga Benatti, Michael J Joyner, Ronan Martin Griffin Berg, Mathias Ried-Larsen, Casper Simonsen
No abstract text is available yet for this article.
April 18, 2024: British Journal of Sports Medicine
#14
JOURNAL ARTICLE
Michiel M A van Buuren, Noortje S Riedstra, Myrthe A van den Berg, Fleur D E M Boel, Harbeer Ahedi, Vahid Arbabi, Nigel K Arden, Sita M A Bierma-Zeinstra, Cindy G Boer, Flavia Cicuttini, Timothy F Cootes, Kay Crossley, David Felson, Willem Paul Gielis, Joshua Heerey, Graeme Jones, Stefan Kluzek, Nancy E Lane, Claudia Lindner, John A Lynch, J Van Meurs, Andrea B Mosler, Amanda E Nelson, M Nevitt, Edwin Oei, Jos Runhaar, Jinchi Tang, Harrie Weinans, Rintje Agricola
PURPOSE: Hip osteoarthritis (OA) is a major cause of pain and disability worldwide. Lack of effective therapies may reflect poor knowledge on its aetiology and risk factors, and result in the management of end-stage hip OA with costly joint replacement. The Worldwide Collaboration on OsteoArthritis prediCtion for the Hip (World COACH) consortium was established to pool and harmonise individual participant data from prospective cohort studies. The consortium aims to better understand determinants and risk factors for the development and progression of hip OA, to optimise and automate methods for (imaging) analysis, and to develop a personalised prediction model for hip OA...
April 18, 2024: BMJ Open
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JOURNAL ARTICLE
Kim Robin van Daalen, Nanine Wyma, Johanna Schauer-Berg, Iris M Blom, Juliette Mattijsen, Razan Othman, Mohamed Eissa, Robbie M Parks, Arthur Wyns, Ahmed Taha Aboushady, Muha Hassan, Tarek Ezzine, Salman Khan, Menna-Allah Elsayed Zayed, Sarah Neggazi, Lujain Alqodmani, Rachel Lowe
No abstract text is available yet for this article.
April 18, 2024: BMJ Global Health
#16
JOURNAL ARTICLE
Andreas Berge, Johannes Lundin, Anna Bläckberg, Torgny Sunnerhagen, Magnus Rasmussen
PURPOSE: Patients with non-beta-hemolytic streptococcal bacteremia (NBHSB) are at risk of infective endocarditis (IE). Patients with cardiac implantable electronic device (CIED) have been described to have an increased risk of IE. The aim of the study was to describe a population-based cohort of patients with NBHSB and CIED and variables associated with IE and recurrent NBHSB. METHODS: All episodes with NBHSB in blood culture from 2015 to 2018 in a population of 1...
April 18, 2024: Infection
#17
JOURNAL ARTICLE
Paolo Morgagni, Maria Bencivenga, Fatima Carneiro, Stefano Cascinu, Sarah Derks, Maria Di Bartolomeo, Claire Donohoe, Clarisse Eveno, Suzanne Gisbertz, Peter Grimminger, Ines Gockel, Heike Grabsh, Paulo Kassab, Rupert Langer, Sara Lonardi, Marco Maltoni, Sheraz Markar, Markus Moehler, Daniele Marrelli, Maria Antonietta Mazzei, Davide Melisi, Carlo Milandri, Paul Stefan Moenig, Bianca Mostert, Gianni Mura, Wojciech Polkowski, John Reynolds, Luca Saragoni, Mark I Van Berge Henegouwen, Richard Van Hillegersberg, Michael Vieth, Giuseppe Verlato, Lorena Torroni, Bas Wijnhoven, Guido Alberto Massimo Tiberio, Han-Kwang Yang, Franco Roviello, Giovanni de Manzoni
BACKGROUND: Many gastric cancer patients in Western countries are diagnosed as metastatic with a median overall survival of less than twelve months using standard chemotherapy. Innovative treatments, like targeted therapy or immunotherapy, have recently proved to ameliorate prognosis, but a general agreement on managing oligometastatic disease has yet to be achieved. An international multi-disciplinary workshop was held in Bertinoro, Italy, in November 2022 to verify whether achieving a consensus on at least some topics was possible...
April 18, 2024: Gastric Cancer
#18
JOURNAL ARTICLE
Gianpaolo Ronconi, Dario Mattia Gatto, Mariantonietta Ariani, Sefora Codazza, Fabio Ingravalle, Giorgio Ferriero, Daniele Coraci, Paola Emilia Ferrara
Parkinson's disease (PD) is defined by progressive worsening of gait, posture, and balance, as well as disability in daily life activities, and improvement in chronic musculoskeletal pain, particularly neck pain associated with worsening of balance. The study's goal is to look into the relationship between scoliosis, balance, and cervical pain in Parkinson's disease patients. Cross-sectional, pilot study. The study included 16 Parkinson's patients. Neck cervical pain was measured using the pain visual analogue scale and the short form McGill pain questionnaire, while dynamic balance was assessed using static balance, Tinetti, Berg Balance, and the Short Physical Performance Battery scales (SPPB)...
April 18, 2024: European Journal of Translational Myology
#19
JOURNAL ARTICLE
Reza Haghani, Hamidreza Erfani, James E McClure, Eirik Grude Flekkøy, Carl Fredrik Berg
In this paper, the underlying problem with the color-gradient (CG) method in handling density-contrast fluids is explored. It is shown that the CG method is not fluid invariant. Based on nondimensionalizing the CG method, a phase-field interface-capturing model is proposed which tackles the difficulty of handling density-contrast fluids. The proposed formulation is developed for incompressible, immiscible two-fluid flows without phase-change phenomena, and a solver based on the lattice Boltzmann method is proposed...
March 2024: Physical Review. E
#20
JOURNAL ARTICLE
Kevin Budding, Jeroen W Bos, Kim Dijkxhoorn, Elisabeth de Zeeuw, Lauri M Bloemenkamp, Eva M Zekveld, Ewout J N Groen, Bart C Jacobs, Ruth Huizinga, H Stephan Goedee, Elisabeth A Cats, Jeanette H W Leusen, Leonard H van den Berg, C Erik Hack, W Ludo van der Pol
BACKGROUND: Multifocal motor neuropathy (MMN) is a rare, chronic immune-mediated polyneuropathy characterized by asymmetric distal limb weakness. An important feature of MMN is the presence of IgM antibodies against gangliosides, in particular GM1 and less often GM2. Antibodies against GM1 bind to motor neurons (MNs) and cause damage through complement activation. The involvement of Schwann cells (SCs), expressing GM1 and GM2, in the pathogenesis of MMN is unknown. METHODS: Combining the data of our 2007 and 2015 combined cross-sectional and follow-up studies in Dutch patients with MMN, we evaluated the presence of IgM antibodies against GM1 and GM2 in serum from 124 patients with MMN and investigated their binding to SCs and complement-activating properties...
April 17, 2024: Journal of Neuroinflammation
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