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M S Eng, J Kaur, L Prasmickaite, B Ø Engesæter, A Weyergang, E Skarpen, K Berg, M G Rosenblum, G M Mælandsmo, A Høgset, S Ferrone, P K Selbo
Triple-negative breast cancer (TNBC) and malignant melanoma are highly aggressive cancers that widely express the cell surface chondroitin sulfate proteoglycan 4 (CSPG4/NG2). CSPG4 plays an important role in tumor cell growth and survival and promotes chemo- and radiotherapy resistance, suggesting that CSPG4 is an attractive target in cancer therapy. In the present work, we applied the drug delivery technology photochemical internalization (PCI) in combination with the novel CSPG4-targeting immunotoxin 225...
March 22, 2018: Photochemical & Photobiological Sciences
Xingyu Ye, Mikael Berg, Caroline Fossum, Per Wallgren, Anne-Lie Blomström
Porcine circovirus 3 (PCV3) is a newly detected circovirus belonging to the family Circoviridae with a circular ssDNA genome of 2000 bp that encodes two proteins-the replicase protein and the capsid protein. PCV3 was discovered for the first time in the US in 2016. After this initial discovery, PCV3 was detected in other parts of the world such as in China, South Korea, Italy and Poland. In this study, 49 tissue samples from Swedish pig herds were screened for PCV3 using PCR and 10 samples were positive and one was uncertain...
March 21, 2018: Virus Genes
Deborah J Wiebe, Cynthia A Berg, Daniel Mello, Caitlin S Kelly
PURPOSE OF REVIEW: This paper aims to examine how self-regulation (i.e., cognition, emotion) and social-regulation (i.e., parents, friends, romantic partners) are interrelated risk and protective factors for type 1 diabetes management during late adolescence and emerging adulthood. RECENT FINDINGS: Problems in cognitive (e.g., executive function) and emotional (e.g., depressive symptoms) self-regulation are associated with poorer management, both at the between- and within-person levels...
March 21, 2018: Current Diabetes Reports
Hanneke E Borst, Gillian S Townend, Mirjam van Eck, Eric Smeets, Mariëlle van den Berg, Aleid Laan, Leopold M G Curfs
This study aimed to determine whether there is a relationship between abnormal foot position and standing and walking ability in individuals with Rett syndrome (RTT), a rare neurological condition primarily affecting females, often accompanied by impaired gross motor function and musculoskeletal deformities. Through means of an online survey, physiotherapists were asked to share information about their work and experience with individuals with RTT. They were asked about their clients' scores on the Rett Syndrome Gross Motor Scale and measures of their foot deformity, passive range of motion of dorsiflexion of the foot, use of supportive footwear, pressure load on the foot, and symmetry in weight bearing...
2018: Journal of Developmental and Physical Disabilities
Caitlin Trottier, Jeffrey Perl, Megan Freeman, Ravi Thadhani, Anders Berg, Sahir Kalim
Protein carbamylation is a post-translational urea-driven protein modification associated with mortality. Free amino acids (AAs) competitively inhibit protein carbamylation and parenteral AA therapy reduces carbamylation in hemodialysis (HD) patients. Peritoneal dialysis (PD) yields differences in urea clearance and AA balance compared with HD, but the influence of PD and intraperitoneal AA solutions on carbamylation is unclear. Thus, we first measured carbamylated albumin (C-Alb; a marker of carbamylation load) in 100 diabetic HD patients frequency-matched by age, sex, and race to 98 diabetic PD subjects from the IMPENDIA trial, which originally compared the metabolic effects of low-glucose PD solutions (incorporating icodextrin and AAs) to a control group (dextrose-only solutions)...
March 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Lora J Wu, Philippa H Gander, Margo van den Berg, T Leigh Signal
BACKGROUND: Many civilian aviation regulators favor evidence-based strategies that go beyond hours-of-service approaches for managing fatigue risk. Several countries now allow operations to be flown outside of flight and duty hour limitations, provided airlines demonstrate an alternative method of compliance that yields safety levels "at least equivalent to" the prescriptive regulations. Here we discuss equivalence testing in occupational fatigue risk management. We present suggested ratios/margins of practical equivalence when comparing operations inside and outside of prescriptive regulations for two common aviation safety performance indicators: total in-flight sleep duration and psychomotor vigilance task reaction speed...
April 1, 2018: Aerospace Medicine and Human Performance
Ahmed S Fahmy, Ulf Neisius, Connie W Tsao, Sophie Berg, Elizabeth Goddu, Patrick Pierce, Tamer A Basha, Long Ngo, Warren J Manning, Reza Nezafat
BACKGROUND: Low scar-to-blood contrast in late gadolinium enhanced (LGE) MRI limits the visualization of scars adjacent to the blood pool. Nulling the blood signal improves scar detection but results in lack of contrast between myocardium and blood, which makes clinical evaluation of LGE images more difficult. METHODS: GB-LGE contrast is achieved through partial suppression of the blood signal using T2 magnetization preparation between the inversion pulse and acquisition...
March 22, 2018: Journal of Cardiovascular Magnetic Resonance
Kathryn Z Guyton, Ivan Rusyn, Weihsueh A Chiu, Denis E Corpet, Martin van den Berg, Matthew K Ross, David C Christiani, Frederick A Beland, Martyn T Smith
Smith et al. (Env. Health Perspect. 124: 713, 2016) identified 10 key characteristics (KCs), one or more of which are commonly exhibited by established human carcinogens. The KCs reflect the properties of a cancer-causing agent, such as 'is genotoxic,' 'is immunosuppressive' or 'modulates receptor-mediated effects,' and are distinct from the hallmarks of cancer, which are the properties of tumors. To assess feasibility and limitations of applying the KCs to diverse agents, methods and results of mechanistic data evaluations were compiled from eight recent IARC Monograph meetings...
February 21, 2018: Carcinogenesis
Walderik W Zomerman, Sabine L A Plasschaert, Siobhan Conroy, Frank J Scherpen, Tiny G J Meeuwsen-de Boer, Harm J Lourens, Sergi Guerrero Llobet, Marlinde J Smit, Lorian Slagter-Menkema, Annika Seitz, Corrie E M Gidding, Esther Hulleman, Pieter Wesseling, Lisethe Meijer, Leon C van Kempen, Anke van den Berg, Daniël O Warmerdam, Frank A E Kruyt, Floris Foijer, Marcel A T M van Vugt, Wilfred F A den Dunnen, Eelco W Hoving, Victor Guryev, Eveline S J M de Bont, Sophia W M Bruggeman
The brain cancer medulloblastoma consists of different transcriptional subgroups. To characterize medulloblastoma at the phosphoprotein-signaling level, we performed high-throughput peptide phosphorylation profiling on a large cohort of SHH (Sonic Hedgehog), group 3, and group 4 medulloblastomas. We identified two major protein-signaling profiles. One profile was associated with rapid death post-recurrence and resembled MYC-like signaling for which MYC lesions are sufficient but not necessary. The second profile showed enrichment for DNA damage, as well as apoptotic and neuronal signaling...
March 20, 2018: Cell Reports
Jinmann Chon, Hee-Sang Kim, Jong Ha Lee, Seung Don Yoo, Dong Hwan Yun, Dong Hwan Kim, Seung Ah Lee, Yoo Jin Han, Yunsoo Soh, Yong Kim, Young Rok Han, Chang Won Won, Seonyoung Han
Objective: To evaluate the association between balance function and asymmetry of knee extension strength in an elderly Korean population. Methods: The strength of the knee extensors in each leg was measured in 306 community-dwelling elderly subjects (age, 76.70±4.85 years) and 25 young healthy subjects (age, 34.23±8.93 years). Based on the difference in strength of both legs, the elderly subjects were divided into symmetric (n=128) and asymmetric (n=178) strength groups using an asymmetry cutoff 20%...
February 2018: Annals of Rehabilitation Medicine
Kunal N Karmali, Donald M Lloyd-Jones, Joep van der Leeuw, David C Goff, Salim Yusuf, Alberto Zanchetti, Paul Glasziou, Rodney Jackson, Mark Woodward, Anthony Rodgers, Bruce C Neal, Eivind Berge, Koon Teo, Barry R Davis, John Chalmers, Carl Pepine, Kazem Rahimi, Johan Sundström
BACKGROUND: Clinical practice guidelines have traditionally recommended blood pressure treatment based primarily on blood pressure thresholds. In contrast, using predicted cardiovascular risk has been advocated as a more effective strategy to guide treatment decisions for cardiovascular disease (CVD) prevention. We aimed to compare outcomes from a blood pressure-lowering treatment strategy based on predicted cardiovascular risk with one based on systolic blood pressure (SBP) level. METHODS AND FINDINGS: We used individual participant data from the Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC) from 1995 to 2013...
March 2018: PLoS Medicine
Kirsten Geneugelijk, Matthias Niemann, Julia Drylewicz, Arjan D van Zuilen, Irma Joosten, Wil A Allebes, Arnold van der Meer, Luuk B Hilbrands, Marije C Baas, C Erik Hack, Franka E van Reekum, Marianne C Verhaar, Elena G Kamburova, Michiel L Bots, Marc A J Seelen, Jan Stephan Sanders, Bouke G Hepkema, Annechien J Lambeck, Laura B Bungener, Caroline Roozendaal, Marcel G J Tilanus, Joris Vanderlocht, Christien E Voorter, Lotte Wieten, Elly M van Duijnhoven, Mariëlle Gelens, Maarten H L Christiaans, Frans J van Ittersum, Azam Nurmohamed, Junior N M Lardy, Wendy Swelsen, Karlijn A van der Pant, Neelke C van der Weerd, Ineke J M Ten Berge, Fréderike J Bemelman, Andries Hoitsma, Paul J M van der Boog, Johan W de Fijter, Michiel G H Betjes, Sebastiaan Heidt, Dave L Roelen, Frans H Claas, Henny G Otten, Eric Spierings
Individual HLA mismatches may differentially impact graft survival after kidney transplantation. Therefore, there is a need for a reliable tool to define permissible HLA mismatches in kidney transplantation. We previously demonstrated that donor-derived Predicted Indirectly ReCognizable HLA Epitopes presented by recipient HLA class II (PIRCHE-II) play a role in de novo donor-specific HLA antibodies formation after kidney transplantation. In the present Dutch multi-center study, we evaluated the possible association between PIRCHE-II and kidney graft failure in 2,918 donor-recipient couples that were transplanted between 1995 and 2005...
2018: Frontiers in Immunology
Daniel Stoessel, Claudia Schulte, Marcia C Teixeira Dos Santos, Dieter Scheller, Irene Rebollo-Mesa, Christian Deuschle, Dirk Walther, Nicolas Schauer, Daniela Berg, Andre Nogueira da Costa, Walter Maetzler
Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging and rests entirely on clinical features. Thus, there is an urgent need for robust diagnostic biofluid markers. Untargeted metabolomics allows establishing low-molecular compound biomarkers in a wide range of complex diseases by the measurement of various molecular classes in biofluids such as blood plasma, serum, and cerebrospinal fluid (CSF)...
2018: Frontiers in Aging Neuroscience
V Perlepe, P Omoumi, A Larbi, D Putineanu, J-E Dubuc, T Schubert, B Vande Berg
PURPOSE: To determine the frequency and causes for limitations in the radiographic evaluation of surgically treated long bone fractures. MATERIALS AND METHODS: Six readers separately scored 140 sets of antero-posterior (AP) and lateral radiographs of surgically treated long bone fractures, using a radiographic union score (RUS). We determined the rate of assessability of the fracture edges at each of the four cortical segments (n=560) seen tangentially on the two radiographs and the causes for non-assessability...
March 16, 2018: Diagnostic and Interventional Imaging
Jan A H Gooszen, Annelijn E Slaman, Susan van Dieren, Suzanne S Gisbertz, Mark I van Berge Henegouwen
BACKGROUND: Diaphragmatic hernias following esophagectomy are mostly asymptomatic. However, they can also present with severe complications and be associated with high morbidity and mortality rates. The aim of this study was to assess the incidence, predictive factors and preferred treatment of symptomatic diaphragmatic hernias and to evaluate the role of prophylactic cruroplasty in patients following esophagectomy for carcinomas of the esophagus or gastro-esophageal junction. METHODS: A prospective database was used to retrospectively analyze consecutive patients who underwent esophagectomy between January 2005 and December 2015...
March 16, 2018: Annals of Thoracic Surgery
Vishal Salunkhe, Iris M De Cuyper, Petros Papadopoulos, Pieter F van der Meer, Brunette B Daal, María Villa-Fajardo, Dirk de Korte, Timo K van den Berg, Laura Gutiérrez
Platelet concentrates (PCs) represent a blood transfusion product with a major concern for safety as their storage temperature (20-24°C) allows bacterial growth, and their maximum storage time period (less than a week) precludes complete microbiological testing. Pathogen inactivation technologies (PITs) provide an additional layer of safety to the blood transfusion products from known and unknown pathogens such as bacteria, viruses, and parasites. In this context, PITs, such as Mirasol Pathogen Reduction Technology (PRT), have been developed and are implemented in many countries...
March 19, 2018: Platelets
Alexandra L Terrill, Maija Reblin, Justin J MacKenzie, Beth Cardell, Jackie Einerson, Cynthia A Berg, Jennifer J Majersik, Lorie Richards
OBJECTIVE: Stroke provides challenges for survivors and partner caregivers. Stroke survivors and caregivers are interconnected in their emotional health, including depression, a common stroke sequelae. The purpose of this study was to develop and test the feasibility of a dyadic positive psychology-based intervention (PPI) for couples coping poststroke. DESIGN: Community-dwelling couples consisted of 1 partner who had a stroke ≥6 months ago and a cohabiting partner caregiver...
February 2018: Rehabilitation Psychology
Jackie M Poos, Lize C Jiskoot, Janne M Papma, John C van Swieten, Esther van den Berg
OBJECTIVES: A meta-analysis of the extent, nature and pattern of memory performance in behavioral variant frontotemporal dementia (bvFTD). Multiple observational studies have challenged the relative sparing of memory in bvFTD as stated in the current diagnostic criteria. METHODS: We performed a meta-analytic review covering the period 1967 to February 2017 of case-control studies on episodic memory in bvFTD versus control participants (16 studies, 383 patients, 603 control participants), and patients with bvFTD versus those with Alzheimer's disease (AD) (20 studies, 452 bvFTD, 874 AD)...
March 19, 2018: Journal of the International Neuropsychological Society: JINS
Signe S Risom, Johanne Lind, Pamela J McCabe, Selina Kikkenborg Berg
Purpose: The CopenHeartRFA trial was designed and conducted to explore the effects of rehabilitation on patients treated with ablation for atrial fibrillation (AF). It included a cardiac rehabilitation program consisting of physical exercise and psychoeducational consultations over 6 months. As part of the evaluation of the CopenHeartRFA trial, both quantitative and qualitative data were collected. The intervention was delivered by a multidisciplinary team. Aim: This study aimed to understand the experience of patients treated for AF with ablation who participated in the CopenHeartRFA cardiac rehabilitation program...
2018: Journal of Multidisciplinary Healthcare
David N Bolam, Bert van den Berg
The lower human gastro-intestinal tract is inhabited by an extremely high density of micro-organisms, collectively termed the colonic microbiota. Just two bacterial phyla dominate this habitat, the Gram-positive Firmicutes and the Gram-negative Bacteroidetes. The colon is further characterised by a relative lack of small, easily accessible nutrients such as simple sugars, lipids and amino acids. Instead, a plethora of diet-derived and host polysaccharides constitute the main source of nutrients. Due to their size and complexity, the uptake of such glycans for metabolic utilisation is an energy-dependent process, which in Bacteroides spp...
March 15, 2018: Current Opinion in Structural Biology
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