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Thromboelastography

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https://www.readbyqxmd.com/read/28202312/corrigendum-to-the-effect-of-dalteparin-on-thromboelastography-in-pregnancy-an-in-vitro-study-int-j-obstet-anesth-2016-28-22-7
#1
L Chow, A Carr, L MacKenzie, A Walker, D Archer, A Lee
No abstract text is available yet for this article.
February 12, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28196659/sutures-impregnated-with-carbazate-activated-polyvinyl-alcohol-reduce-intraperitoneal-adhesions
#2
F Fredriksson, F Sellberg, T Bowden, T Engstrand, D Berglund, H E Lilja
BACKGROUND: Intraperitoneal adhesions cause significant morbidity. They occur after peritoneal trauma, which induces oxidative stress with production of inflammatory cytokines, peroxidized proteins (carbonyls) and lipids (aldehydes). This study aimed to investigate if carbazate-activated polyvinyl alcohol (PVAC), an aldehyde-carbonyl inhibitor, can reduce intraperitoneal adhesions in an experimental model. MATERIAL AND METHODS: Male Sprague-Dawley rats (n=110) underwent laparotomy, cecal abrasion and construction of a small bowel anastomosis...
February 1, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28190562/a-combined-approach-to-early-detect-in-vitro-drug-induced-hemostatic-changes-in-preclinical-safety
#3
Myriam Defontis, Serge Côté, David Ledieu
Early detection of drug-induced alterations of hemostasis is challenging. Drugs can affect different components of the Virchow's triad and measurement of plasmatic coagulation times lacks sensitivity. New techniques for a more global assessment of the hemostasis are now available: the impedance platelet aggregometry, the thromboelastography and the thrombin generation measurement. The aim of this study was to evaluate three techniques (i.e.: Multiplate(®), TEG(®) and CAT) for the in vitro detection of the effect of a drug known to induce hemostatic alterations in a preclinical safety environment...
February 9, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28175394/185%C3%A2-the-utility-of-thromboelastography-for-predicting-the-risk-of-progression-of-intracranial-hemorrhage-in-traumatic-brain-injury-patients
#4
Abigail J Rao, Amber Laurie, Cole Hilliard, Rochelle Fu, Tori Lennox, Ronald Barbosa, Martin Schreiber, Susan Rowell
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28154462/the-effects-of-oral-administration-of-yunnan-baiyao-on-blood-coagulation-in-beagle-dogs-as-measured-by-kaolin-activated-thromboelastography-and-buccal-mucosal-bleeding-times
#5
Jami Frederick, Søren Boysen, Catherine Wagg, Serge Chalhoub
We examined the effects of oral administration of Yunnan Baiyao (YB) on hemostasis by measuring buccal mucosal bleeding times (BMBTs) and doing citrated kaolin-activated whole-blood thromboelastography (TEG). In a randomized controlled crossover trial 8 beagle dogs were given either placebo or 1000 mg of YB orally every 12 h for 5 consecutive treatments. Blood was drawn 24 h before treatment and 2 and 24 h after the last treatment, and the BMBT was measured in each sample in duplicate. The TEG analysis was done in duplicate 60 ± 5 min after sample collection...
January 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/28133787/reference-values-for-kaolin-activated-thromboelastography-in-volunteers-of-anhui-province-in-china
#6
Jun-Bo Sun, Mao-Hong Bian, Tao Zhong, Ying-Yu Lu, Bang-Qiang Zhu, Hui-Qin Wen, Hai-Liang Hu
BACKGROUND: The assessment of the coagulation status using thromboelastography (TEG) in Chinese population has less been reported. This study aimed to establish reliable reference values for kaolin-activated TEG in Chinese volunteers. METHODS: A total of 1681 Chinese adult individuals were recruited for this study. The reference individuals were stratified by gender and age, and the TEG values were measured on the basis of strict quality control. The 95% reference values were determined using nonparametric statistical methods...
January 30, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28123708/synthetic-polyphosphate-inhibits-endogenous-coagulation-and-platelet-aggregation-in-vitro
#7
Xiaoyang Yang, Mengjie Wan, Ting Liang, Minyuan Peng, Fangping Chen
Platelet-derived polyphosphate has previously been indicated to induce coagulation. However, industrially synthesized polyphosphate has been found to have different effects from those of the platelet-derived form. The present study investigated whether synthetic sodium polyphosphate inhibits coagulation using routine coagulation tests and thromboelastography. Synthetic polyphosphate was found to inhibit adenosine diphosphate-, epinephrine-, arachidonic acid-, ristocetin-, thrombin-, oxytocin- and pituitrin-induced platelet aggregation...
January 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28115278/the-role-of-thromboelastography-teg-in-pediatric-patients-with-sinusoidal-obstructive-syndrome-receiving-defibrotide
#8
Joanna L Gendreau, Christine Knoll, Roberta H Adams, Leon L Su
Sinusoidal obstructive syndrome (SOS) is a potentially fatal form of hepatic injury following hematopoietic stem cell transplant (HSCT). Patients can develop liver dysfunction, portal hypertension, ascites, coagulopathies, and multi-system organ failure. The mortality rate of severe SOS has been reported as high as 98% by Day 100 post-transplant. Defibrotide, which is now approved for the treatment of SOS, has significantly decreased mortality. Defibrotide is a polynucleotide with pro-fibrinolytic, anti-ischemic, and anti-inflammatory activity...
January 20, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28110132/thromboelastographic-characterization-of-the-activated-clotting-system-in-children-with-sickle-cell-trait-or-sickle-cell-disease
#9
Shveta Gupta, Roxana Carmona, Jemily Malvar, Guy Young
BACKGROUND: Recent epidemiological evidence suggests sickle cell disease (SCD) and sickle cell trait (SCT) is a risk factor for venous thromboembolism. The increased in-vivo markers of thrombin generation support the notion that such patients are in a chronic hypercoagulable state. In an attempt to better understand the underlying mechanism, global hemostatic assays including thrombin generation assay (TGA) and thromboelastography (TEG) have been utilized by several groups, but thus far, have shown inconsistent results either due to small sample size or technical differences...
September 21, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28097681/thromboelastography-in-dogs-with-chronic-hepatopathies
#10
W Fry, C Lester, N M Etedali, S Shaw, A DeLaforcade, C R L Webster
BACKGROUND: The coagulation status of dogs with liver disease is difficult to predict using conventional coagulation testing. HYPOTHESIS/OBJECTIVES: To evaluate thromboelastography (TEG) results and associations with conventional coagulation results and indicators of disease severity and prognosis in dogs with chronic hepatopathies (CH). ANIMALS: Twenty-one client-owned dogs. METHODS: Dogs with CH were prospectively (10 dogs) and retrospectively (11 dogs) enrolled from 2008 to 2014...
January 18, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28076307/evaluation-of-the-greiner-bio-one-serum-separator-bca-fast-clot-tube
#11
Goce Dimeski, Julie Johnston, Paul P Masci, Kong-Nan Zhao, Nigel Brown
BACKGROUND: Current commercial tubes have difficulties in producing "true" serum from all blood samples even within the recommended clotting times. Hence, Becton Dickinson (BD) and now Greiner have produced tubes containing thrombin as the procoagulant to reduce the clotting time and increase the possibility of producing serum from anticoagulated blood samples. METHODS: The Greiner BCA Fast Clot (GBBCAFC) tube was evaluated in a hospital environment using 40 participants, (30 healthy and 10 undergoing renal dialysis) for 32 analytes against the Greiner lithium heparin tube and the BD Rapid Serum Tubes (BD RST) tube measured on Beckman DxC 800 and DxI 800 analyzers...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28072942/introduction-of-a-simple-algorithm-improves-thromboelastography-guided-blood-product-use-during-cardiac-surgery
#12
N B Spath, H M Lala, S C Robinson
No abstract text is available yet for this article.
January 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28070995/haplotype-of-platelet-receptor-p2ry12-gene-is-associated-with-residual-clopidogrel-on-treatment-platelet-reactivity
#13
Xiao-Yan Nie, Jun-Lei Li, Yong Zhang, Yang Xu, Xue-Li Yang, Yu Fu, Guang-Kai Liang, Yun Lu, Jian Liu, Lu-Wen Shi
OBJECTIVE: To investigate a possible association between common variations of the P2RY12 and the residual clopidogrel on-treatment platelet reactivity after adjusting for the influence of CYP2C19 tested by thromboelastography (TEG). METHODS: One hundred and eighty patients with acute coronary syndrome (ACS) treated with clopidogrel and aspirin were included and platelet function was assessed by TEG. Five selected P2RY12 single nucleotide polymorphisms (SNPs; rs6798347, rs6787801, rs6801273, rs6785930, and rs2046934), which cover the common variations in the P2RY12 gene and its regulatory regions, and three CYP2C19 SNPs ((*)2,(*)3,(*)17) were genotyped and possible haplotypes were analyzed...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28062209/thromboelastogram-does-not-detect-pre-injury-anticoagulation-in-acute-trauma-patients
#14
Jawad T Ali, Mitchell J Daley, Nina Vadiei, Zachary Enright, Joseph Nguyen, Sadia Ali, Jayson D Aydelotte, Pedro G Teixeira, Thomas B Coopwood, Carlos Vr Brown
PURPOSE: Thromboelastography (TEG) has been recommended to characterize post-traumatic coagulopathy, yet no study has evaluated the impact of pre-injury anticoagulation (AC) on TEG variables. We hypothesized patients on pre-injury AC have a greater incidence of coagulopathy on TEG compared to those without AC. METHODS: This retrospective chart review evaluated all trauma patients admitted to an urban, level one trauma center from February 2011 to September 2014 who received a TEG within the first 24h...
December 26, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28058211/organ-transplantation-and-drug-eluting-stents-perioperative-challenges
#15
REVIEW
Aparna Dalal
Patients listed for organ transplant frequently have severe coronary artery disease (CAD), which may be treated with drug eluting stents (DES). Everolimus and zotarolimus eluting stents are commonly used. Newer generation biolimus and novolimus eluting biodegradable stents are becoming increasingly popular. Patients undergoing transplant surgery soon after the placement of DES are at increased risk of stent thrombosis (ST) in the perioperative period. Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor such as clopidogrel, prasugrel and ticagrelor is instated post stenting to decrease the incident of ST...
December 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/28052313/thromboelastography-teg-or-rotational-thromboelastometry-rotem-to-monitor-haemostatic-treatment-in-bleeding-patients-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#16
REVIEW
A Wikkelsø, J Wetterslev, A M Møller, A Afshari
Coagulopathy and severe bleeding are associated with high mortality. We evaluated haemostatic treatment guided by the functional viscoelastic haemostatic assays, thromboelastography or rotational thromboelastometry in bleeding patients. We searched for randomised, controlled trials irrespective of publication status, publication date, blinding status, outcomes published or language from date of inception to 5 January 2016 in six bibliographic databases. We included 17 trials (1493 participants), most involving cardiac surgery...
January 4, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28042854/in-vitro-anti-thrombotic-activity-of-extracts-from-blacklip-abalone-haliotis-rubra-processing-waste
#17
Hafiz Ansar Rasul Suleria, Barney M Hines, Rama Addepalli, Wei Chen, Paul Masci, Glenda Gobe, Simone A Osborne
Waste generated from the processing of marine organisms for food represents an underutilized resource that has the potential to provide bioactive molecules with pharmaceutical applications. Some of these molecules have known anti-thrombotic and anti-coagulant activities and are being investigated as alternatives to common anti-thrombotic drugs, like heparin and warfarin that have serious side effects. In the current study, extracts prepared from blacklip abalone (Haliotis rubra) processing waste, using food grade enzymes papain and bromelain, were found to contain sulphated polysaccharide with anti-thrombotic activity...
December 31, 2016: Marine Drugs
https://www.readbyqxmd.com/read/28039526/platelet-inhibition-in-shunted-infants-on-aspirin-at-short-and-midterm-follow-up
#18
Dongngan T Truong, Joyce T Johnson, David K Bailly, Jason R Clawson, Xiaoming Sheng, Phillip T Burch, Madolin K Witte, L LuAnn Minich
There are few data to guide aspirin therapy to prevent shunt thrombosis in infants. We aimed to determine if aspirin administered at conventional dosing in shunted infants resulted in ≥50% arachidonic acid (AA) inhibition in short and midterm follow-up using thromboelastography with platelet mapping (TEG-PM) and to describe bleeding and thrombotic events during follow-up. We performed a prospective observational study of infants on aspirin following Norwood procedure, aortopulmonary shunt alone, or cavopulmonary shunt surgery...
December 30, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/28017804/persistent-fibrinolysis-shutdown-associated-with-increased-mortality-in-severely-injured-trauma-patients
#19
Jonathan P Meizoso, Charles A Karcutskie, Juliet J Ray, Nicholas Namias, Carl I Schulman, Kenneth G Proctor
BACKGROUND: Acute fibrinolysis shutdown is associated with early mortality after trauma, however no prior studies have investigated the incidence of persistent fibrinolysis or its association with mortality. We test the hypothesis that persistent fibrinolysis shutdown is associated with mortality in critically ill trauma patients. STUDY DESIGN: Thromboelastography was performed upon ICU admission in 181 adult trauma patients and at 1-week in a subset of 78 patients...
December 22, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28004055/thrombocytopathy-leading-to-impaired-in-vivo-haemostasis-and-thrombosis-in-platelet-type-von-willebrand-disease
#20
Harmanpreet Kaur, Kathryn Corscadden, Jerry Ware, Maha Othman
Platelet defects due to hyper-responsive GPIbα causing enhanced VWF interaction, counter-intuitively result in bleeding rather than thrombosis. The historical explanation of platelet/VWF clearance fails to explain mechanisms of impaired haemostasis particularly in light of reported poor platelet binding to fibrinogen. This study aimed to evaluate the defects of platelets with hyper-responsive GPIbα and their contribution to impaired in vivo thrombosis. Using the PT-VWD mouse model, platelets from the hTg(G233V) were compared to control hTg(WT) mice...
December 22, 2016: Thrombosis and Haemostasis
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