Raizl G Sussman, Joy Mburu, MacGregor Steele, Annie Bang, Jeremy Friedman, Ran Goldman, Melanie Kirby, Margaret L Rand, Victor S Blanchette, Fred G Pluthero, Suzan Williams, Walter H A Kahr
BACKGROUND: Constitutive inflammation and hemostatic activation have been identified as key contributors to the pathophysiology of sickle cell disease (SCD), leading to clinical consequences such as vaso-occlusive crises and stroke. Patients with hemoglobin SS (HbSS) and hemoglobin SC (HbSC) genotypes are reported to have different symptoms, as do patients in steady-state and crisis situations. Differences among these groups remain unclear in pediatric patients. OBJECTIVES: To compare hemostatic activity in HbSS and HbSC pediatric patients during steady state, in crisis, and in clinical follow-up and compare HbSS and HbSC patients with normal healthy children...
March 2024: Research and Practice in Thrombosis and Haemostasis