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https://www.readbyqxmd.com/read/27920574/combined-epidural-morphine-and-bupivacaine-in-the-treatment-of-lumbosacral-radicular-neuropathic-pain-a-noncontrolled-prospective-study
#1
Simone Vigneri, Gianfranco Sindaco, Marco La Grua, Matteo Zanella, Laura Ravaioli, Valentina Paci, Gilberto Pari
OBJECTIVE: The aim of this study was to investigate the therapeutic effectiveness of epidural morphine and bupivacaine in patients with chronic lumbosacral radicular neuropathic pain after the cessation of treatment. METHODS: Twenty-two patients with chronic lumbosacral pain with neuropathic features were enrolled. An indwelling catheter was placed into the epidural space, and each patient received an epidural injection of morphine chlorhydrate and bupivacaine up to three times a day...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27919777/statistical-models-for-the-analysis-of-zero-inflated-pain-intensity-numeric-rating-scale-data
#2
Joseph L Goulet, Eugenia Buta, Harini Bathulapalli, Ralitza Gueorguieva, Cynthia A Brandt
: Pain intensity is often measured in clinical and research settings using the 0 to 10 numeric rating scale (NRS). NRS scores are recorded as discrete values, and in some samples they may display a high proportion of zeroes and a right-skewed distribution. Despite this, statistical methods for normally distributed data are frequently used in the analysis of NRS data. We present results from an observational cross-sectional study examining the association of NRS scores with patient characteristics using data collected from a large cohort of 18,935 Veterans in VA care diagnosed with a potentially painful musculoskeletal disorder...
December 2, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27919589/preincisional-and-postoperative-epidural-morphine-ropivacaine-ketamine-and-naloxone-treatment-for-postoperative-pain-management-in-upper-abdominal-surgery
#3
Hou-Chuan Lai, Chung-Bao Hsieh, Chih-Shung Wong, Chun-Chang Yeh, Zhi-Fu Wu
OBJECTIVE(S): Previous studies have shown that preincisional epidural morphine, bupivacaine, and ketamine combined with epidural anesthesia (EA) and general anesthesia (GA) provided pre-emptive analgesia for upper abdominal surgery. Recent studies reported that ultralow-dose naloxone enhanced the antinociceptive effect of morphine in rats. This study investigated the benefits of preincisional and postoperative epidural morphine + ropivacaine + ketamine + naloxone (M + R + K + N) treatment for achieving postoperative pain relief in upper abdominal surgery...
December 2, 2016: Acta Anaesthesiologica Taiwanica: Official Journal of the Taiwan Society of Anesthesiologists
https://www.readbyqxmd.com/read/27912953/evaluating-the-effect-of-matricaria-recutita-and-mentha-piperita-herbal-mouthwash-on-management-of-oral-mucositis-in-patients-undergoing-hematopoietic-stem-cell-transplantation-a-randomized-double-blind-placebo-controlled-clinical-trial
#4
Maria Tavakoli Ardakani, Sara Ghassemi, Mahshid Mehdizadeh, Faraz Mojab, Jamshid Salamzadeh, Samaneh Ghassemi, Abbas Hajifathali
OBJECTIVES: To investigate the effects of Matricaria recutita and Mentha piperita on oral mucositis (OM) in patients undergoing hematopoietic stem cell transplantation (HSCT). DESIGN: Randomized double blind placebo controlled clinical trial. SETTING: Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, and Bone Marrow Transplantation Center at Taleghani Teaching Hospital, Tehran, Iran. PARTICIPANTS: Sixty patients undergoing HSCT were randomly assigned to two groups: placebo (n=33), and herbal mouthwash group (n=27)...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27904961/muscle-elastography-a-new-imaging-technique-for-multiple-sclerosis-spasticity-measurement
#5
G Illomei, G Spinicci, E Locci, M G Marrosu
Multiple sclerosis (MS) spasticity is currently evaluated on the basis of neurological examinations such as Ashworth Scale (AS) and 0-10 NRS. Severity of spasticity is difficult to quantify. We investigated the use of real time elastography (RTHE) ultrasounds for evaluating objectively the muscle fibers status in MS spasticity patients and their changes after a new antispasticity treatment. Two studies were performed. In study A, 110 MS patients underwent a neurological evaluation based on the AS and RTHE. The RTHE images were scored with the new 1-5 muscle fibers rigidity imaging scale, here called MEMSs (Muscle Elastography Multiple Sclerosis Score)...
November 30, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27900548/predictors-of-response-to-corticosteroids-for-dyspnea-in-advanced-cancer-patients-a-preliminary-multicenter-prospective-observational-study
#6
Masanori Mori, Akemi Naito Shirado, Tatsuya Morita, Kenichiro Okamoto, Yoshinobu Matsuda, Yoshihisa Matsumoto, Hirohide Yamada, Hiroki Sakurai, Etsuko Aruga, Keisuke Kaneishi, Hiroaki Watanabe, Takashi Yamaguchi, Takuya Odagiri, Shuji Hiramoto, Hiroyuki Kohara, Naoki Matsuo, Hideki Katayama, Tomohiro Nishi, Takashi Matsui, Satoru Iwase
PURPOSE: Although corticosteroids can relieve dyspnea in advanced cancer patients, factors predicting the response remain unknown. We aimed to explore potential factors predicting the response to corticosteroids for dyspnea in advanced cancer patients. METHODS: In this preliminary multicenter prospective observational study, we included patients who had metastatic or locally advanced cancer, were receiving specialized palliative care services, and had a dyspnea intensity of ≥3 on a 0-10 Numerical Rating Scale (NRS) (worst during the last 24 h)...
November 29, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27898175/interventions-for-promoting-participation-in-shared-decision-making-for-children-with-cancer
#7
REVIEW
Imelda Coyne, Dónal P O'Mathúna, Faith Gibson, Linda Shields, Edith Leclercq, Greg Sheaf
BACKGROUND: This is an update of the Cochrane systematic review of shared decision-making (SMD) making published in 2013. Children's rights to have their views heard in matters that affect their lives are now well established since the publication of the UN Convention treaty (1989). Children with cancer generally prefer to be involved in decision-making and consider it important that they have the opportunity to take part in decision-making concerning their health care, even in end-of-life decisions...
November 29, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27896665/ultrasound-guided-thoracic-paravertebral-block-by-the-paralaminar-in-plane-approach-using-a-microconvex-array-transducer-methodological-utility-based-on-anatomical-structures
#8
Yasuko Taketa, Taro Fujitani, Yumi Irisawa, Satoko Sudo, Kazushi Takaishi
OBJECTIVE: We evaluated the analgesic feasibility of paralaminar in-plane (PL) approach for ultrasound-guided thoracic paravertebral block (USG-TPVB). As the needle trajectory was expected to be closely affected by the distance from the skin to the lamina-transverse process junction (LTPJ), we examined the correlativity between them on computed tomography (CT) or ultrasonography. METHODS: Thirty-two patients undergoing thoracotomy were recruited. We measured the distances between the skin and LTPJ using preoperative CT (S-L) and procedural ultrasonography (US-L)...
November 28, 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/27896457/the-value-of-quantitative-sensory-testing-in-spine-research
#9
Anja Tschugg, Wolfgang N Löscher, Sara Lener, Sebastian Hartmann, Matthias Wildauer, Sabrina Neururer, Claudius Thomé
The improvement of pain and functionality is the major goal of a surgical intervention. Thus, the purpose of the present prospective study was to evaluate whether subjective sensory deficits in patients with lumbar radiculopathy caused by a lumbar disc herniation are related to clinical status, using several outcome scores and the quantitative sensory testing (QST) pre- and 12 months postoperatively. We applied the QST in 52 patients with a single lumbar disc herniation treated by lumbar sequestrectomy pre- and 12 months postoperatively...
November 28, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27867509/comparison-of-fentanyl-iontophoretic-transdermal-system-and-routine-care-with-morphine-intravenous-patient-controlled-analgesia-in-the-management-of-early-postoperative-mobilisation-results-from-a-randomised-study
#10
Richard M Langford, Kuang-Yi Chang, Li Ding, Jeffrey Abraham
INTRODUCTION: Fentanyl iontophoretic transdermal system (ITS) (IONSYS(®), The Medicines Company, Parsippany, NJ, USA) and morphine intravenous (IV) patient-controlled analgesia (PCA) have demonstrated equivalent pain control in several published studies. The primary objective of the current study was to compare fentanyl ITS with morphine IV PCA with regard to the patient's ability to mobilise with acute postoperative pain. METHODS: In this multicentre, open-label, randomised, active-controlled, prospective phase IV study, postoperative patients initially received IV morphine and were titrated to pain score ⩽ 4out of 10 on a Numeric Rating Scale (NRS) and then received fentanyl ITS (up to 240 µg (6 doses)/hour; up to a maximum of 3...
November 2016: British Journal of Pain
https://www.readbyqxmd.com/read/27862626/pro-and-anti-inflammatory-cytokine-associations-with-major-depression-in-cancer-patients
#11
Madeline Li, Ekaterina Kouzmina, Megan McCusker, Danielle Rodin, Paul C Boutros, Christopher J Paige, Gary Rodin
OBJECTIVE: Cytokines may be linked to depression, although it has been challenging to demonstrate this association in cancer because of the overlap between depressive symptoms and other sickness behaviors. This study investigates the relationship between cytokines and depression in cancer patients, accounting for confounding clinical and methodological factors. METHODS: The GRID Hamilton Rating Scale for Depression and Neurotoxicity Rating Scale (NRS) for cytokine-induced sickness behaviors were administered to 61 cancer patients and 38 healthy controls...
November 15, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27862339/novel-trpm8-agonist-cooling-compound-against-chronic-itch-results-from-a-randomized-double-blind-controlled-pilot-study-in-dry-skin
#12
S Ständer, M Augustin, D Roggenkamp, C Blome, T Heitkemper, A C Worthmann, G Neufang
BACKGROUND: Patients suffering from chronic pruritus (CP) due to dry skin with are often applying emollients containing menthol. However, topical menthol may be irritating and of weak potency in severe pruritus. Two TRPM8 agonists, (1R,2S,5R)-N-(2-(2-pyridinyl)ethyl)-2-ispropyl-5-methylcyclohexancarboxamide and menthoxypropan-ediol, combined as Cooling Compound (CC) have shown stronger activation of TRPM8 than menthol. OBJECTIVES: Objective of this study was to evaluate the efficacy and safety of CC in alleviating pruritus in patients with dry itchy skin...
November 11, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27859948/peripheral-nerve-stimulation-in-the-treatment-of-chronic-pain-syndromes-from-nerve-injury-a-multicenter-observational-study
#13
Gianni Colini Baldeschi, Alessandro Dario, Giuliano De Carolis, Nicola Luxardo, Massimo Natale, Paola Nosella, Alfonso Papa, Massimiliano Raggi, Claudio Reverberi
INTRODUCTION: Assessing the feasibility, technical implications, and clinical benefits of peripheral nerve stimulation (PNS) performed by an implantable pulse generator (IPG) located close to the stimulation site. MATERIALS AND METHODS: Selected patients were affected by neuropathic pain associated with a documented peripheral nerve lesion, refractory to conventional surgical or pharmacological treatment. A PNS system specifically designed for peripheral placement (Neurimpulse, Padova, Italy) was implanted and followed for six months, recording the degree of patient's satisfaction (PGI-I questionnaire), the pain numerical rating scale (NRS) and the quality of life (SF36 questionnaire), as well as any change in drug regimen and work capability...
November 16, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27859872/patient-participation-in-postoperative-pain-assessment-after-spine-surgery-in-a-recovery-unit
#14
Kirsten Kaptain, Vibeke Bregnballe, Pia Dreyer
AIMS AND OBJECTIVES: This study aimed to explore how patients undergoing spine surgery participated in postoperative pain assessment in a recovery unit. BACKGROUND: Despite advances in medicine, pharmaceutical and technical knowledge, patients report considerable postoperative pain after spine surgery. Research shows that patients require efficient individual pain treatment and that their participation has a positive effect on pain treatment. DESIGN: This study was based on a phenomenological-hermeneutic design...
November 9, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27858685/kinesio-taping-in-patients-with-lumbar-disc-herniation-a-randomised-controlled-double-blind-study
#15
Betul Yavuz Keles, Ebru Yilmaz Yalcinkaya, Berrin Gunduz, Ayşe Nur Bardak, Belgin Erhan
BACKGROUND: Lumbar disc herniation (LDH) causes pain and working day loss when activated. Patients spend most of their time in the hospital. And also it may limit patients' daily living activities. Kinesio Taping (KT) is a method that can be easily applied to the patients and does not interfere with their daily activities or movements of body. OBJECTIVE: This study investigated the effects of KT in patients with low back pain due to LDH. METHODS: Randomised-placebo controlled double blind clinical trial...
November 11, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27857632/comparison-of-2-multimodal-interventions-with-and-without-whole-body-vibration-therapy-plus-traction-on-pain-and-disability-in-patients-with-nonspecific-chronic-low-back-pain
#16
Gianni F Maddalozzo, Brian Kuo, Walker A Maddalozzo, Conner D Maddalozzo, Johnny W Galver
OBJECTIVE: The purpose of this secondary data analysis was to compare the effect of 2 multimodal exercise-based physical therapy interventions (one with and one without whole-body vibration [WBV] therapy plus traction) on pain and disability in patients with nonspecific chronic low back pain (NSCLBP). METHODS: We conducted a secondary analysis of data from 2 distinct samples. One sample was from the Focus on Therapeutic Outcomes Inc. (FOTO) group (n = 55, age 55...
December 2016: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/27852717/efficacy-of-acupuncture-for-degenerative-lumbar-spinal-stenosis-protocol-for-a-randomised-sham-acupuncture-controlled-trial
#17
Zongshi Qin, Yulong Ding, Jiani Wu, Jing Zhou, Likun Yang, Xiaoxu Liu, Zhishun Liu
INTRODUCTION: Degenerative lumbar spinal stenosis (DLSS) is a major public health problem and the primary reason why older adults seek lumbar spine surgery. Acupuncture may be effective for DLSS, but the evidence supporting this possibility is still limited. METHODS AND ANALYSIS: A total of 80 participants with DLSS will be randomly allocated to either an acupuncture group or a sham acupuncture (SA) group at a ratio of 1:1. 24 treatments will be provided over 8 weeks...
November 16, 2016: BMJ Open
https://www.readbyqxmd.com/read/27851665/measurement-properties-of-the-brazilian-portuguese-version-of-the-lumbar-spine-instability-questionnaire
#18
Amanda Costa Araujo, Lucíola da Cunha Menezes Costa, Crystian Bittencourt Oliveira, Priscila Kalil Morelhão, Rúben Faria Negrão Filho, Rafael Zambelli Pinto, Leonardo Oliveira Pena Costa
STUDY DESIGN: Cross-cultural adaptation and analysis of measurement properties. OBJECTIVE: To translate and cross-culturally adapt the Lumbar Spine Instability Questionnaire (LSIQ) into Brazilian-Portuguese and to test its measurement properties in Brazilian patients with low back pain. SUMMARY OF BACKGROUND DATA: The selection of subgroup of patients that respond better to specific interventions is the top research priority in the field of back pain...
November 15, 2016: Spine
https://www.readbyqxmd.com/read/27847703/treatment-of-post-latissimus-dorsi-flap-breast-reconstruction-pain-with-continuous-paravertebral-nerve-blocks-a-retrospective-review
#19
Jonathan T Unkart, Jennifer A Padwal, Brian M Ilfeld, Anne M Wallace
OBJECTIVES: The addition of a perioperative continuous paravertebral nerve block (cPVB) to a single-injection thoracic paravertebral nerve block (tPVB) has demonstrated improved analgesia in breast surgery. However, its use following isolated post-mastectomy reconstruction using a latissimus dorsi flap (LDF) has not previously been examined. METHODS: We performed a retrospective review of patients who underwent salvage breast reconstruction with a unilateral LDF by a single surgeon...
October 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27844474/assessment-of-acute-pain-in-trauma-a-retrospective-prehospital-evaluation
#20
Stine Hebsgaard, Anne Mannering, Stine T Zwisler
OBJECTIVE: To elucidate pain treatment with analgesics in a prehospital trauma population. DESIGN: Retrospective database study. SETTING: Prehospital data from the anesthesiologist-manned Mobile Emergency Care Unit (MECU) in Odense, Denmark, were extracted and subjected to analysis. PATIENTS: During the period of January 1, 2013 to December 31, 2014, patients with the diagnoses "unspecified multiple injuries," "examination and observation following traffic accident," "examination and observation following other accident," and "commotio cerebri" were included in the analysis...
September 2016: Journal of Opioid Management
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