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https://www.readbyqxmd.com/read/29669701/crizotinib-in-patients-with-advanced-inoperable-inflammatory-myofibroblastic-tumours-with-and-without-anaplastic-lymphoma-kinase-gene-alterations-european-organisation-for-research-and-treatment-of-cancer-90101-create-a-multicentre-single-drug-prospective-non
#1
Patrick Schöffski, Jozef Sufliarsky, Hans Gelderblom, Jean-Yves Blay, Sandra J Strauss, Silvia Stacchiotti, Piotr Rutkowski, Lars H Lindner, Michael G Leahy, Antoine Italiano, Nicolas Isambert, Maria Debiec-Rychter, Raf Sciot, Thomas Van Cann, Sandrine Marréaud, Axelle Nzokirantevye, Sandra Collette, Agnieszka Wozniak
BACKGROUND: An inflammatory myofibroblastic tumour (IMFT) is a rare mesenchymal neoplasm characterised by anaplastic lymphoma kinase (ALK) gene rearrangements. We assessed the activity and safety of crizotinib, a tyrosine kinase inhibitor, targeting ALK in patients with advanced IMFT either with or without ALK alterations. METHODS: We did a multicentre, biomarker-driven, single-drug, non-randomised, open-label, two-stage phase 2 trial (European Organisation for Research and Treatment of Cancer 90101 CREATE) at 13 study sites (five university hospitals and eight specialty clinics) in eight European countries (Belgium, France, Germany, Italy, Netherlands, Poland, Slovakia, and the UK)...
April 12, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29668365/mental-health-across-the-globe-special-issue-of-issues-in-mental-health-nursing-on-the-topic-of
#2
Sandra Thomas
No abstract text is available yet for this article.
April 2018: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29666976/do-youth-with-separation-anxiety-disorder-differ-in-anxiety-sensitivity-from-youth-with-other-anxiety-disorders
#3
Dagmar Kr Hannesdottir, Sandra Bjorg Sigurjonsdottir, Urdur Njardvik, Thomas H Ollendick
Studies on the relationship between separation anxiety disorder (SAD) in childhood and panic disorder (PD) in adolescence and adulthood have yielded results which suggest a common underlying vulnerability for both disorders. In this study, we examined whether one such possible vulnerability-anxiety sensitivity-differed for youth diagnosed with SAD versus other anxiety disorders. Anxiety sensitivity was assessed using the Childhood Anxiety Sensitivity Index (CASI) in 315 clinic-referred youth (ages 6-17, 113 girls)...
April 17, 2018: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/29666885/referred-cramping-phantom-hand-pain-elicited-in-the-face-and-eliminated-by-peripheral-nerve-block
#4
Caroline Dietrich, Sandra Nehrdich, Annette Zimmer, Alexander Ritter, Gunther O Hofmann, Wolfgang H R Miltner, Thomas Weiss
Phantom limb pain is a restricting condition for a substantial number of amputees with quite different characteristics of pain. Here, we report on a forearm amputee with constant phantom pain in the hand, in whom we could regularly elicit the rare phenomenon of referred cramping phantom pain by touching the face. To clarify the underlying mechanisms, we followed the cramp during the course of an axillary blockade of the brachial plexus. During the blockade, both phantom pain and the referred cramp were abolished, while a referred sensation of "being touched at the phantom" persisted...
April 17, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29662167/sequencing-of-prostate-cancers-identifies-new-cancer-genes-routes-of-progression-and-drug-targets
#5
David C Wedge, Gunes Gundem, Thomas Mitchell, Dan J Woodcock, Inigo Martincorena, Mohammed Ghori, Jorge Zamora, Adam Butler, Hayley Whitaker, Zsofia Kote-Jarai, Ludmil B Alexandrov, Peter Van Loo, Charlie E Massie, Stefan Dentro, Anne Y Warren, Clare Verrill, Dan M Berney, Nening Dennis, Sue Merson, Steve Hawkins, William Howat, Yong-Jie Lu, Adam Lambert, Jonathan Kay, Barbara Kremeyer, Katalin Karaszi, Hayley Luxton, Niedzica Camacho, Luke Marsden, Sandra Edwards, Lucy Matthews, Valeria Bo, Daniel Leongamornlert, Stuart McLaren, Anthony Ng, Yongwei Yu, Hongwei Zhang, Tokhir Dadaev, Sarah Thomas, Douglas F Easton, Mahbubl Ahmed, Elizabeth Bancroft, Cyril Fisher, Naomi Livni, David Nicol, Simon Tavaré, Pelvender Gill, Christopher Greenman, Vincent Khoo, Nicholas Van As, Pardeep Kumar, Christopher Ogden, Declan Cahill, Alan Thompson, Erik Mayer, Edward Rowe, Tim Dudderidge, Vincent Gnanapragasam, Nimish C Shah, Keiran Raine, David Jones, Andrew Menzies, Lucy Stebbings, Jon Teague, Steven Hazell, Cathy Corbishley, Johann de Bono, Gerhardt Attard, William Isaacs, Tapio Visakorpi, Michael Fraser, Paul C Boutros, Robert G Bristow, Paul Workman, Chris Sander, Freddie C Hamdy, Andrew Futreal, Ultan McDermott, Bissan Al-Lazikani, Andrew G Lynch, G Steven Bova, Christopher S Foster, Daniel S Brewer, David E Neal, Colin S Cooper, Rosalind A Eeles
Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer samples. From joint analysis of these cancers with those from previous studies (930 cancers in total), we found evidence for 22 previously unidentified putative driver genes harboring coding mutations, as well as evidence for NEAT1 and FOXA1 acting as drivers through noncoding mutations. Through the temporal dissection of aberrations, we identified driver mutations specifically associated with steps in the progression of prostate cancer, establishing, for example, loss of CHD1 and BRCA2 as early events in cancer development of ETS fusion-negative cancers...
April 16, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29653054/one-enzyme-to-build-them-all-ring-size-engineered-siderophores-inhibit-swarming-motility-of-vibrio
#6
Sina Rütschlin, Sandra Gunesch, Thomas Boettcher
Bacteria compete for ferric iron by producing siderophores and some microbes engage in piracy by scavenging sidero-phores of their competitors. The macrocyclic hydroxamate siderophore avaroferrin of Shewanella algae inhibits swarm-ing of Vibrio alginolyticus by evading this piracy. Avaroferrin as well as related putrebactin and bisucaberin are produced by the IucC-like synthetases AvbD, PubC, and BibCC. Here, we established that they are capable of synthesizing not only their native product but also other siderophores...
April 13, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29644435/sexual-health-in-patients-with-rheumatoid-arthritis-and-the-association-between-physical-fitness-and-sexual-function-a-cross-sectional-study
#7
Thomas Ernst Dorner, Carolin Berner, Sandra Haider, Igor Grabovac, Thomas Lamprecht, Karl Heinrich Fenzl, Ludwig Erlacher
The aim of this study was to examine sexual health in patients with rheumatoid arthritis (RA), and to analyse factors associated with sexual health with a focus on physical fitness. One hundred RA patients aged between 18 and 65 years were included in a cross-sectional study. Handgrip strength and knee extensor strength were measured with a dynamometer, and physical performance with the Short Physical Performance Battery (SPPB). Fifty-four patients, mean age 47.8 (SD 10.6) years, 61% female, answered a questionnaire about sexual health...
April 11, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29627858/first-detection-of-echinococcus-granulosus-sensu-stricto-g1-in-dogs-in-central-sudan
#8
Rihab Ali Omer, Arwid Daugschies, Sandra Gawlowska, Ayman Elnahas, Peter Kern, Sofia Bashir, Mohammed Sir Alkhatim Ali, Amin Osman, Thomas Romig
Eighty-four stray dogs shot as a part of a governmental rabies control program in two neighboring towns of central Sudan were examined for the presence of Echinococcus spp. and other intestinal helminths. Echinococcus worms were identified to species level by PCR and gene sequencing. For comparative reasons, rectal content of the necropsied dogs was examined for helminth eggs and subjected to copro-PCR for Echinococcus. At necropsy, 51.2% (43/84) of the dogs harbored Echinococcus canadensis (G6/7) worms with worm burdens ranging from 22,000 to 80,000...
April 7, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29625231/the-oxidized-linoleic-acid-metabolite-12-13-dihome-mediates-thermal-hyperalgesia-during-inflammatory-pain
#9
Béla Zimmer, Carlo Angioni, Tabea Osthues, Andy Toewe, Dominique Thomas, Sandra C Pierre, Gerd Geisslinger, Klaus Scholich, Marco Sisignano
Eicosanoids play a crucial role in inflammatory pain. However, there is very little knowledge about the contribution of oxidized linoleic acid metabolites in inflammatory pain and peripheral sensitization. Here, we identify 12,13-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME), a cytochrome P450-derived linoleic acid metabolite, as crucial mediator of thermal hyperalgesia during inflammatory pain. We found 12,13-DiHOME in increased concentrations in peripheral nervous tissue during acute zymosan- and complete Freund's Adjuvant-induced inflammatory pain...
April 3, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29618651/large-scale-complete-genome-sequencing-and-phylodynamic-analysis-of-eastern-equine-encephalitis-virus-reveal-source-sink-transmission-dynamics-in-the-united-states
#10
Yi Tan, Tommy Tsan-Yuk Lam, Lea A Heberlein-Larson, Sandra C Smole, Albert J Auguste, Scott Hennigan, Rebecca A Halpin, Nadia Fedorova, Vinita Puri, Timothy B Stockwell, Meghan H Shilts, Theodore Andreadis, Philip M Armstrong, Robert B Tesh, Scott C Weaver, Thomas R Unnasch, Alexander T Ciota, Laura D Kramer, Suman R Das
Eastern equine encephalitis virus (EEEV) has a high case-fatality rate in horses and humans, and Florida has been hypothesized to be the source of EEEV epidemics for the northeastern U.S. To test this hypothesis, we sequenced complete genomes of 433 EEEV strains collected within the U.S. from 1934 to 2014. Phylogenetic analysis suggested EEEV evolves relatively slowly and that transmission is enzootic in Florida, characterized by higher genetic diversity and long-term local persistence. In contrast, EEEV in New York and Massachusetts were characterized by lower genetic diversity, multiple introductions, and shorter local persistence...
April 4, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29618598/routine-assessment-and-promotion-of-physical-activity-in-healthcare-settings-a-scientific-statement-from-the-american-heart-association
#11
REVIEW
Felipe Lobelo, Deborah Rohm Young, Robert Sallis, Michael D Garber, Sandra A Billinger, John Duperly, Adrian Hutber, Russell R Pate, Randal J Thomas, Michael E Widlansky, Michael V McConnell, Elizabeth A Joy
Physical inactivity is one of the most prevalent major health risk factors, with 8 in 10 US adults not meeting aerobic and muscle-strengthening guidelines, and is associated with a high burden of cardiovascular disease. Improving and maintaining recommended levels of physical activity leads to reductions in metabolic, hemodynamic, functional, body composition, and epigenetic risk factors for noncommunicable chronic diseases. Physical activity also has a significant role, in many cases comparable or superior to drug interventions, in the prevention and management of >40 conditions such as diabetes mellitus, cancer, cardiovascular disease, obesity, depression, Alzheimer disease, and arthritis...
April 4, 2018: Circulation
https://www.readbyqxmd.com/read/29618003/cohort-profile-the-pregnancy-and-neonatal-diabetes-outcomes-in-remote-australia-pandora-study
#12
I-Lynn Lee, Brydie Purbrick, Federica Barzi, Alex Brown, Christine Connors, Cherie Whitbread, Elizabeth Moore, Marie Kirkwood, Alison Simmonds, Paula van Dokkum, Elizabeth Death, Stacey Svenson, Sian Graham, Vanya Hampton, Joanna Kelaart, Danielle Longmore, Angela Titmuss, Jacqueline Boyle, Julie Brimblecombe, Richard Saffery, Anita D'Aprano, Michael R Skilton, Leigh C Ward, Sumaria Corpus, Shridhar Chitturi, Sujatha Thomas, Sandra Eades, Chrissie Inglis, Karen Dempsey, Michelle Dowden, Michael Lynch, Jeremy Oats, Harold D McIntyre, Paul Zimmet, Kerin O'Dea, Jonathan E Shaw, Louise J Maple-Brown
No abstract text is available yet for this article.
March 29, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29610677/potential-association-of-lmna-associated-generalized-lipodystrophy-with-juvenile-dermatomyositis
#13
Melis Sahinoz, Shafaq Khairi, Ashley Cuttitta, Graham F Brady, Amit Rupani, Rasimcan Meral, Marwan K Tayeh, Peedikayil Thomas, Meredith Riebschleger, Sandra Camelo-Piragua, Jeffrey W Innis, M Bishr Omary, Daniel E Michele, Elif A Oral
Background: Juvenile dermatomyositis (JDM) is an auto-immune muscle disease which presents with skin manifestations and muscle weakness. At least 10% of the patients with JDM present with acquired lipodystrophy. Laminopathies are caused by mutations in the lamin genes and cover a wide spectrum of diseases including muscular dystrophies and lipodystrophy. The p.T10I LMNA variant is associated with a phenotype of generalized lipodystrophy that has also been called atypical progeroid syndrome...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29605166/identification-of-generalist-registered-dietitian-nutritionist-knowledge-gaps-in-diabetes-medical-nutrition-therapy-compared-to-diabetes-credentialed-registered-dietitian-nutritionists-results-of-a-survey-to-inform-educational-opportunities
#14
Kimberly Bisanz, Anna Parker, Cecily Byrne, Sandra A Parker, Joan Thomas, Juliet Mancino, Rosa K Hand
No abstract text is available yet for this article.
March 29, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29605135/mass-spectrometry-profiling-reveals-altered-plasma-levels-of-monohydroxy-fatty-acids-and-related-lipids-in-healthy-humans-after-controlled-exposure-to-biodiesel-exhaust
#15
Sandra Gouveia-Figueira, Masoumeh Karimpour, Jenny A Bosson, Anders Blomberg, Jon Unosson, Maria Sehlstedt, Jamshid Pourazar, Thomas Sandström, Annelie F Behndig, Malin L Nording
Experimental human exposure studies are an effective tool to study adverse health effects from acute inhalation of particulate matter and other constituents of air pollution. In this randomized and double-blinded crossover study, we investigated the systemic effect on bioactive lipid metabolite levels after controlled biodiesel exhaust exposure of healthy humans and compared it to filtered air at a separate exposure occasion. Eicosanoids and other oxylipins, as well as endocannabinoids and related lipids, were quantified in plasma from 14 healthy volunteers at baseline and at three subsequent time points (2, 6, and 24 h) after 1 h exposure sessions...
August 14, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29602701/delineating-the-serotype-specific-neutralizing-antibody-response-to-a-live-attenuated-tetravalent-dengue-vaccine
#16
Gregory D Gromowski, Sandra Henein, Chandrika B Kannadka, David A Barvir, Stephen J Thomas, Aravinda M de Silva, Richard G Jarman
The dengue virus (DENV) vaccines that are licensed or in clinical development consist of DENV serotype 1-4 tetravalent formulations given simultaneously and are not acquired sequentially like natural infections. It is unclear what effect this has on development of protective levels of immunity to all four serotypes. Serotype-specific neutralizing antibody (NAb) is considered the most relevant correlate of protection from dengue disease. Here we assessed levels of serotype-specific and cross-reactive NAb in immune sera from 10 subjects vaccinated with a live attenuated tetravalent DENV vaccine developed at the Walter Reed Army Institute of Research...
March 27, 2018: Vaccine
https://www.readbyqxmd.com/read/29598861/rapid-deployment-versus-conventional-bioprosthetic-valve-replacement-for-aortic-stenosis
#17
Stephan Ensminger, Buntaro Fujita, Timm Bauer, Helge Möllmann, Andreas Beckmann, Raffi Bekeredjian, Sabine Bleiziffer, Sandra Landwehr, Christian W Hamm, Friedrich W Mohr, Hugo A Katus, Wolfgang Harringer, Thomas Walther, Christian Frerker
BACKGROUND: Surgical aortic valve replacement using conventional biological valves (CBVs) is the standard of care for treatment of old patients with aortic valve disease. Recently, rapid deployment valves (RDVs) have been introduced. OBJECTIVES: The purpose of this study was to report the nationwide German experience concerning RDVs for treatment of aortic valve stenosis and provide a head-to-head comparison with CBVs. METHODS: A total of 22,062 patients who underwent isolated surgical aortic valve replacement using CBV or RDV between 2011 and 2015 were enrolled into the German Aortic Valve Registry...
April 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29592962/microcrystalline-tyrosine-and-aluminum-as-adjuvants-in-allergen-specific-immunotherapy-protect-from-ige-mediated-reactivity-in-mouse-models-and-act-independently-of-inflammasome-and-tlr-signaling
#18
Deborah S Leuthard, Agathe Duda, Sandra N Freiberger, Sina Weiss, Isabella Dommann, Gabriele Fenini, Emmanuel Contassot, Matthias F Kramer, Murray A Skinner, Thomas M Kündig, Matthew D Heath, Pål Johansen
Allergen immunotherapy (AIT) is the only modality that can modify immune responses to allergen exposure, but therapeutic coverage is low. One strategy to improve AIT safety and efficacy is the use of new or improved adjuvants. This study investigates immune responses produced by microcrystalline tyrosine (MCT)-based vaccines as compared with conventional aluminum hydroxide (alum). Wild-type, immune-signaling-deficient, and TCR-transgenic mice were treated with different Ags (e.g., OVA and cat dander Fel d 1), plus MCT or alum as depot adjuvants...
March 28, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29579266/time-dependent-postmortem-redistribution-of-opioids-in-blood-and-alternative-matrices
#19
Lana Brockbals, Sandra N Staeheli, Dominic Gascho, Lars C Ebert, Thomas Kraemer, Andrea E Steuer
Forensic postmortem case interpretation can be challenging, in particular due to postmortem redistribution (PMR) phenomena. Recent studies have shown that computed tomography (CT)-guided collection of biopsy samples using a robotic arm (virtobot) provides a valuable tool for systematic studies on time-dependent PMR. Utilizing this strategy, several cases involving opioid use such as methadone, fentanyl, tramadol, codeine, oxycodone and hydrocodone were evaluated for time-dependent concentration changes and potential redistribution mechanisms...
March 20, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29574443/early-initiation-of-post-sternotomy-cardiac-rehabilitation-exercise-training-scar-study-protocol-for-a-randomised-controlled-trial-and-economic-evaluation
#20
Stuart Ennis, Grace Lobley, Sandra Worrall, Richard Powell, Peter K Kimani, Amir Jahan Khan, Prithwish Banerjee, Thomas Barker, Gordon McGregor
INTRODUCTION: Current guidelines recommend abstinence from supervised cardiac rehabilitation (CR) exercise training for 6 weeks post-sternotomy. This practice is not based on empirical evidence, thus imposing potentially unnecessary activity restrictions. Delayed participation in CR exercise training promotes muscle atrophy, reduces cardiovascular fitness and prolongs recovery. Limited data suggest no detrimental effect of beginning CR exercise training as early as 2 weeks post-surgery, but randomised controlled trials are yet to confirm this...
March 23, 2018: BMJ Open
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