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Fibrinolysis

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https://www.readbyqxmd.com/read/29779246/regulation-of-plasminogen-activation-on-cell-surfaces-and-fibrin
#1
REVIEW
Tetsumei Urano, Francis J Castellino, Yuko Suzuki
The fibrinolytic system dissolves fibrin and maintains vascular patency. Recent advances in imaging analyses allowed visualization of the spatiotemporal regulatory mechanism of fibrinolysis, as well as its regulation by other plasma haemostasis cofactors. Vascular endothelial cells (VECs) retain tissue-type plasminogen activator (tPA) after secretion and maintain high plasminogen (plg) activation potential on their surfaces. As in plasma, the serpin, plasminogen activator inhibitor type 1 (PAI-1), regulates fibrinolytic potential via inhibition of the VEC surface-bound plg activator, tPA...
May 20, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29775165/a-case-of-horner-s-syndrome-after-catheter-based-fibrinolysis-for-pulmonary-embolism
#2
Julia Loewenthal, Ankit Patel, Robert Kurtz, Gregory Piazza
No abstract text is available yet for this article.
May 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29772364/pathophysiology-and-non-surgical-treatment-of-chronic-subdural-hematoma-from-past-to-present-to-future
#3
REVIEW
Dana C Holl, Victor Volovici, Clemens M F Dirven, Wilco C Peul, Fop van Kooten, Korné Jellema, Niels A van der Gaag, Ishita P Miah, Kuan H Kho, Heleen M den Hertog, Hester F Lingsma, Ruben Dammers
BACKGROUND: Chronic subdural hematoma (CSDH) is one of the more frequent pathological entities in daily neurosurgical practice. Historically, CSDH was considered a progressive, recurrent bleeding with a traumatic etiology. However, recent evidence suggests a complex intertwined pathway of inflammation, angiogenesis, local coagulopathy, recurrent microbleeds and exudates. The aim of the present review is to collect existing data on pathophysiology of CSDH in order to direct further research questions aiming to optimize treatment for the individual patient...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29770793/pulmonary-embolism
#4
REVIEW
Menno V Huisman, Stefano Barco, Suzanne C Cannegieter, Gregoire Le Gal, Stavros V Konstantinides, Pieter H Reitsma, Marc Rodger, Anton Vonk Noordegraaf, Frederikus A Klok
Pulmonary embolism (PE) is caused by emboli, which have originated from venous thrombi, travelling to and occluding the arteries of the lung. PE is the most dangerous form of venous thromboembolism, and undiagnosed or untreated PE can be fatal. Acute PE is associated with right ventricular dysfunction, which can lead to arrhythmia, haemodynamic collapse and shock. Furthermore, individuals who survive PE can develop post-PE syndrome, which is characterized by chronic thrombotic remains in the pulmonary arteries, persistent right ventricular dysfunction, decreased quality of life and/or chronic functional limitations...
May 17, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29767547/prehospital-fibrinolysis-followed-by-urgent-percutaneous-coronary-intervention-after-st-elevation-myocardial-infarction
#5
Umair Khalid, Hani Jneid, Ali Emin Denktas
No abstract text is available yet for this article.
May 16, 2018: Future Cardiology
https://www.readbyqxmd.com/read/29761522/thrombotic-characteristics-of-extracellular-vesicles-derived-from-prostate-cancer-cells
#6
Hassan A Al Saleh, Sandor Haas-Neill, Ali Al-Hashimi, Anil Kapoor, Bobby Shayegan, Richard C Austin, Khalid Al-Nedawi
BACKGROUND: Prostate cancer (PC) patients in advanced stages of the disease have high risk of blood coagulation complications. The procoagulant molecule Tissue factor (TF), and the fibrinolysis inhibitor plasminogen activator inhibitor-1 PAI-1 play important role in this complication. Extracellular vesicles (EV) shed from cancer cells may contribute to the regulation of TF and PAI-1. The procoagulant activity of EV can be associated with the oncogenic and metastatic characteristics of their cells...
May 15, 2018: Prostate
https://www.readbyqxmd.com/read/29760205/abnormal-plasma-clot-formation-and-fibrinolysis-reveal-bleeding-tendency-in-patients-with-partial-factor-xi-deficiency
#7
Gillian N Gidley, Lori A Holle, John Burthem, Paula H B Bolton-Maggs, Feng-Chang Lin, Alisa S Wolberg
Individuals with factor XI (FXI) deficiency have a variable bleeding risk that cannot be predicted from plasma FXI antigen or activity. This limitation can result in under- or overtreatment of patients and risk of bleeding or thrombosis. Previously, plasma clot fibrinolysis assays showed sensitivity to bleeding tendency in a small cohort of patients with severe FXI deficiency. Here, we determined the ability of plasma clot formation, structure, and fibrinolysis assays to predict bleeding tendency in a larger, independent cohort of patients with severe and partial FXI deficiency...
May 22, 2018: Blood Advances
https://www.readbyqxmd.com/read/29759857/multiple-dose-intravenous-tranexamic-acid-further-reduces-hidden-blood-loss-after-total-hip-arthroplasty-a-randomized-controlled-trial
#8
Yiting Lei, Qiang Huang, Zeyu Huang, Jinwei Xie, Guo Chen, Fuxing Pei
BACKGROUND: The most appropriate dose of tranexamic acid in total hip arthroplasty (THA) has not been decided. This study was conducted to evaluate the clinical effects of multiple-dose intravenous tranexamic acid (IV-TXA) in THA. METHODS: One hundred fifty patients were randomized to receive one dose of IV-TXA before incision, followed by 2 doses of IV-TXA (group A), or 3 doses of IV-TXA (group B), or 4 doses of IV-TXA (group C) at 3-hour intervals. The primary outcome was hidden blood loss (HBL)...
April 23, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29758989/the-double-hazard-of-bleeding-and-thrombosis-in-hemostasis-from-a-clinical-point-of-view-a-global-assessment-by-rotational-thromboelastometry-rotem
#9
Olga Meltem Akay
Hemostasis is a complex dynamic process involving bleeding and thrombosis as two end-points. Conventional coagulation tests which are measured in plasma examine only isolated portions of the coagulation cascade, thereby giving no information on important interactions essential to the clinical evaluation of hemostatic function. Thromboelastography (TEG), originally described in 1948 has improved over the decades and become a valuable tool of coagulation testing because of the limitations of standard coagulation tests...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29758126/abrogating-fibrinolysis-does-not-improve-bleeding-or-rfviia-rfviii-treatment-in-a-non-mucosal-venous-injury-model-in-haemophilic-rodents
#10
Rikke Stagaard, Matthew J Flick, Barbara Bojko, Krzysztof Goryński, Paulina Z Goryńska, Carsten D Ley, Lisbeth H Olsen, Tom Knudsen
BACKGROUND: Fibrinolysis may exacerbate bleeding in haemophilia A (HA). Accordingly, antifibrinolytics have been used to help maintain haemostatic control. While antifibrinolytic drugs have been proven effective in the treatment of mucosal bleeds in the oral cavity, their efficacy in non-mucosal tissues remain an open question of significant clinical interest. OBJECTIVE: To determine whether inhibiting fibrinolysis improves the outcome in non-mucosal haemophilic tail vein transection (TVT) bleeding models, and to determine whether a standard ex vivo clotting/fibrinolysis assay can be used as a predictive surrogate for in vivo efficacy...
May 14, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29746949/variation-in-coagulation-and-fibrinolysis-genes-evaluated-for-their-contribution-to-cerebrovascular-complications-in-adults-with-bacterial-meningitis-in-the-netherlands
#11
A T Kloek, H N Khan, M Valls Seron, A Jongejan, A H Zwinderman, F Baas, A van der Ende, D van de Beek, B Ferwerda, M C Brouwer
OBJECTIVE: To study whether genetic variation in coagulation and fibrinolysis genes contributes to cerebrovascular complications in bacterial meningitis. METHODS: We performed a nationwide prospective genetic association study in adult community-acquired bacterial meningitis patients. The exons and flanking regions of 16 candidate genes involved in coagulation and fibrinolysis pathways were sequenced. We analyzed whether genetic variation in these genes resulted in a higher risk of cerebrovascular complications, unfavorable outcome and differences in thrombocyte count on admission...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746945/activation-of-coagulation-and-endothelium-with-concurrent-impairment-of-anticoagulant-mechanisms-in-patients-with-typhoid-fever
#12
Hanna K de Jong, Chris M Parry, Thomas W van der Vaart, Liesbeth M Kager, Stannie J van den Ende, Rapeephan R Maude, Lalith Wijedoru, Aniruddha Ghose, Mohammed U Hasan, Mohammed A Hossain, Arjan M Dondorp, Steve Baker, M Abul Faiz, Joost C M Meijers, W Joost Wiersinga
OBJECTIVES: Typhoid fever caused by Salmonella Typhi remains a major burden worldwide. Gastrointestinal bleeding can be seen in up to 10 percent of patients and may be fatal. The coagulopathy, which may be the driver of this severe complication in patients with typhoid fever, however is ill defined. The aim of this study was to evaluate the activation of coagulation, anticoagulation, and fibrinolysis in patients with acute typhoid fever. METHODS: . Parameters of coagulation and fibrinolysis were measured in 28 hospitalized patients with culture-confirmed or PCR-confirmed typhoid fever and compared to 38 age- and sex-matched healthy volunteers...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29743762/thromboelastographic-analysis-of-hemostatic-abnormalities-in-dengue-patients-admitted-in-a-multidisciplinary-intensive-care-unit-a-cross-sectional-study
#13
V K Sureshkumar, Deepak Vijayan, Shamim Kunhu, Zuhail Mohamed, Sujith Thomas, Muraleedharan Raman
Background: Dengue fever is an important tropical infection causing significant mortality. The pathophysiology of hematological abnormalities in dengue remains poorly studied. In this study, we analyzed the hematological abnormalities by thromboelastography (TEG). Methods: This cross-sectional study evaluated complicated dengue patients with TEG. Thromboelastographic variables were categorized into six patterns: factor deficiency, platelet dysfunction, enzymatic hypercoagulability, combined enzymatic and platelet hypercoagulability, primary fibrinolysis, and secondary hyperfibrinolysis...
April 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29743045/haematological-and-fibrinolytic-status-of-nigerian-women-with-post-partum-haemorrhage
#14
Ian Roberts, Haleema Shakur, Bukola Fawole, Modupe Kuti, Oladapo Olayemi, Adenike Bello, Olayinka Ogunbode, Taiwo Kotila, Chris O Aimakhu, Tolulase Olutogun, Beverley J Hunt, Sumaya Huque
BACKGROUND: Early treatment with tranexamic acid reduces deaths due to bleeding after post-partum haemorrhage. We report the prevalence of haematological, coagulation and fibrinolytic abnormalities in Nigerian women with postpartum haemorrhage. METHODS: We performed a secondary analysis of the WOMAN trial to assess laboratory data and rotational thromboelastometry (ROTEM) parameters in 167 women with postpartum haemorrhage treated at University College Hospital, Ibadan, Nigeria...
May 9, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29741245/pathogenesis-and-diagnosis-of-disseminated-intravascular-coagulation
#15
REVIEW
M Levi
Several clinical conditions, in particular those associated with a systemic inflammatory response, can cause some degree of activation of coagulation but when the procoagulant stimulus is sufficiently severe and overcomes the natural anticoagulant mechanisms of coagulation, disseminated intravascular coagulation (DIC) may occur. The clinical manifestations of DIC encompass multiorgan dysfunction caused by fibrin-platelet clots in the microcirculation, and bleeding caused by consumption of platelets and coagulation factors...
May 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29739066/basic-evaluation-of-the-newly-developed-lias-auto-p-fdp-assay-and-the-influence-of-plasmin-%C3%AE-2-plasmin-inhibitor-complex-values-on-discrepancy-in-the-comparison-with-lias-auto-d-dimer-neo-assay
#16
Osamu Kumano, Masahiro Ieko, Yutaka Komiyama, Sumiyoshi Naito, Mika Yoshida, Nobuhiko Takahashi, Kazumasa Ohmura, Junki Hayasaki, Mineji Hayakawa
BACKGROUND: Laboratory determination of fibrin/fibrinogen degradation products (FDP) levels, along with that of the D-dimer, is important for assessing the fibrinolytic situation. Recently, we developed a new FDP reagent "Lias Auto P-FDP", which can detect various FDP fragments. The purpose of this study was to evaluate the basic performance of the newly developed Lias Auto P-FDP and compare it with Lias Auto D-Dimer Neo assay. METHODS: The within-run precision of Lias Auto P-FDP and Lias Auto D-Dimer was determined 20 times in low and high value controls...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29738877/oral-tranexamic-acid-is-equivalent-to-topical-tranexamic-acid-without-drainage-in-primary-total-hip-arthroplasty-a-double-blind-randomized-clinical-trial
#17
Ze-Yu Luo, Duan Wang, Wei-Kun Meng, Hao-Yang Wang, Hui Pan, Fu-Xing Pei, Zong-Ke Zhou
PURPOSE: To compare the efficacy of multiple doses of oral tranexamic acid (TXA) with topical TXA administration in reducing blood loss following total hip arthroplasty (THA). PATIENTS AND METHODS: In this double-blinded trial, 117 patients undergoing primary THA were randomized to receive 2 g TXA orally 2 h preoperatively, and two doses of 1 g TXA postoperatively (oral group) or 3 g of TXA topical administration in the operating room (topical group). The primary outcome was a reduction in hemoglobin concentration...
May 1, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29732309/dry-socket-etiology-diagnosis-and-clinical-treatment-techniques
#18
REVIEW
John Mamoun
Dry socket, also termed fibrinolytic osteitis or alveolar osteitis, is a complication of tooth exodontia. A dry socket lesion is a post-extraction socket that exhibits exposed bone that is not covered by a blood clot or healing epithelium and exists inside or around the perimeter of the socket or alveolus for days after the extraction procedure. This article describes dry socket lesions; reviews the basic clinical techniques of treating different manifestations of dry socket lesions; and shows how microscope level loupe magnification of 6× to 8× or greater, combined with co-axial illumination or a dental operating microscope, facilitate more precise treatment of dry socket lesions...
April 2018: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29728334/intracoronary-infusion-of-alprostadil-and-nitroglycerin-with-targeted-perfusion-microcatheter-in-stemi-patients-with-coronary-slow-flow-phenomenon
#19
Xincheng Sheng, Song Ding, Heng Ge, Yujun Sun, Lingcong Kong, Jie He, Jun Pu, Ben He
BACKGROUND: The treating aims of ST-segment elevation myocardial infarction (STEMI) are vessels recanalization and coronary flow restoration. Coronary slow flow phenomenon (CSFP) is one of the common complications in STEMI patients after percutaneous coronary intervention (PCI) and leads to a higher incidence of adverse clinical outcomes. Alprostadil is a kind of liposomal prostaglandin E1 with beneficial effects on vasodilation, platelet disaggregation and fibrinolysis. But it still remains unclear that whether alprostadil can improve the coronary perfusion in STEMI patients with CSFP after PCI...
April 25, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29727892/hemostasis-during-extreme-exertion
#20
Cécile Hélène Kicken, Adam Miszta, Hilde Kelchtermans, Bas De Laat
Exercise is protective against cardiovascular disease, but can also provoke sudden cardiac death, a phenomenon referred to as "the exercise paradox." Extreme exertion is known to induce a rebalanced hemostatic state by causing hypercoagulability and concomitantly enhanced fibrinolysis. Over the past decade, novel techniques for quantifying hemostasis have been introduced, which may provide new insights into this process. This review summarizes recent literature on the effect of extreme exertion of both short and long duration on coagulation, fibrinolysis, and recovery of hemostatic balance...
May 4, 2018: Seminars in Thrombosis and Hemostasis
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