keyword
MENU ▼
Read by QxMD icon Read
search

targeted weight loss

keyword
https://www.readbyqxmd.com/read/29684457/%C3%A2-%C2%BA4-gaba-a-receptors-of-hippocampal-pyramidal-neurons-are-associated-with-resilience-against-activity-based-anorexia-for-adolescent-female-mice-but-not-for-males
#1
Yi-Wen Chen, Hannah Actor-Engel, Chiye Aoki
Activity-based anorexia (ABA) is an animal model of anorexia nervosa, a mental illness with highest mortality and with onset that is most frequently during adolescence. We questioned whether vulnerability of adolescent mice to ABA differs between sexes and whether individual differences in resilience are causally linked to alpha4betadelta-GABAA R expression. C57BL6/J WT and α4-KO adolescent male and female mice underwent ABA induction by combining wheel access with food restriction. ABA vulnerability was measured as the extent of food restriction-evoked hyperactivity on a running wheel and body weight losses...
April 20, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29683555/clinical-obesity-services-in-public-hospitals-in-australia-a-position-statement-based-on-expert-consensus
#2
E Atlantis, N Kormas, K Samaras, P Fahey, P Sumithran, S Glastras, G Wittert, K Fusco, R Bishay, T Markovic, L Ding, K Williams, I Caterson, V Chikani, P Dugdale, J Dixon
We aimed to describe the current state of specialist obesity services for adults with clinically severe obesity in public hospitals in Australia, and to analyse the gap in resources based on expert consensus. We conducted two surveys to collect information about current and required specialist obesity services and resources using open-ended questionnaires. Organizational level data were sought from clinician expert representatives of specialist obesity services across Australia in 2017. Fifteen of 16 representatives of current services in New South Wales (n = 8), Queensland (n = 1), Victoria (n = 2), South Australia (n = 3), and the Australian Capital Territory (n = 1) provided data...
April 23, 2018: Clinical Obesity
https://www.readbyqxmd.com/read/29681862/increased-o-glcnacylation-of-endothelial-nitric-oxide-synthase-compromises-the-anti-contractile-properties-of-perivascular-adipose-tissue-in-metabolic-syndrome
#3
Rafael M da Costa, Josiane F da Silva, Juliano V Alves, Thiago B Dias, Diane M Rassi, Luis V Garcia, Núbia de Souza Lobato, Rita C Tostes
Under physiological conditions, the perivascular adipose tissue (PVAT) negatively modulates vascular contractility. This property is lost in experimental and human obesity and in the metabolic syndrome, indicating that changes in PVAT function may contribute to vascular dysfunction associated with increased body weight and hyperglycemia. The O -linked β-N-acetylglucosamine ( O -GlcNAc) modification of proteins ( O -GlcNAcylation) is a unique posttranslational process that integrates glucose metabolism with intracellular protein activity...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29675407/pancreatic-aquaporin-7-a-novel-target-for-anti-diabetic-drugs
#4
REVIEW
Leire Méndez-Giménez, Silvia Ezquerro, Inês V da Silva, Graça Soveral, Gema Frühbeck, Amaia Rodríguez
Aquaporins comprise a family of 13 members of water channels (AQP0-12) that facilitate a rapid transport of water across cell membranes. In some cases, these pores are also permeated by small solutes, particularly glycerol, urea or nitric oxide, among other solutes. Several aquaporins have been identified in the pancreas, an exocrine and endocrine organ that plays an essential role in the onset of insulin resistance and type 2 diabetes. The exocrine pancreas, which accounts for 90% of the total pancreas, secretes daily large volumes of a near-isotonic fluid containing digestive enzymes into the duodenum...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29673597/sennoside-a-protects-mitochondrial-structure-and-function-to-improve-high-fat-diet-induced-hepatic-steatosis-by-targeting-vdac1
#5
Jiamei Le, Weiping Jia, Yongning Sun
Mitochondrial dysfunction is mainly associated with high-fat-diet (HFD)-induced hepatic steatosis. Sennoside A (SA), a commonly used clinical stimulant laxative, is reported to improve energy metabolism and insulin resistance. However, the effect and mechanism of SA on HFD-induced hepatic steatosis remain largely unknown. The aim of this study was to determine the effect and mechanism of SA on HFD-induced hepatic steatosis in mice. We examined the liver and body weight of mice to evaluate the physical changes in the liver...
April 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29672196/the-effects-of-synbiotic-supplementation-on-body-mass-index-metabolic-and-inflammatory-biomarkers-and-appetite-in-patients-with-metabolic-syndrome-a-triple-blind-randomized-controlled-trial
#6
Samira Rabiei, Mehdi Hedayati, Bahram Rashidkhani, Navid Saadat, Rahebeh Shakerhossini
It has been shown recently that metabolic syndrome is associated with gut dysbiosis. The gut microbiota may be the main target for prevention or treatment of metabolic syndrome. We investigated the effects of synbiotic supplementation on metabolic syndrome. In this triple-blinded clinical trial, 46 Iranian patients with metabolic syndrome, from both sexes, aged 25-70 years, who fulfilled inclusion criteria were randomly categorized to receive either the synbiotic or a placebo capsule, twice a day for three months, plus a weight-loss diet using stratified random sampling based on body mass index (BMI)...
April 19, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29670749/adult-weight-management-across-the-community-population-level-impact-of-the-lose-it-to-win-it-challenge
#7
J J VanWormer, R F Pereira, A Sillah, A C Sidebottom, G A Benson, R Lindberg, C Winters, J L Boucher
Objective: Excess body weight negatively impacts health, but there are few evaluations of low-intensity weight management challenge programs in defined populations. This study examined weight change in adults who participated in the LOSE IT to WIN IT (LIWI) health challenge in a US community. The community-level impact on body mass index was also explored. Methods: Body weight was analysed over 1 year in the cohort of LIWI enrolees, stratified by participants who were healthy weight or overweight/obese at baseline...
April 2018: Obesity Science & Practice
https://www.readbyqxmd.com/read/29670748/factors-associated-with-healthy-and-unhealthy-workplace-eating-behaviours-in-individuals-with-overweight-obesity-with-and-without-binge-eating-disorder
#8
S L Leung, J A Barber, A Burger, R D Barnes
Objective: Most Americans spend an average of 8 hours per day in the workplace. Current understanding of eating behaviours in the workplace and their association with overweight, obesity and binge eating disorder (BED) is limited. Workplace eating behaviours and weight-related self-efficacy were examined in a sample of 98 individuals with overweight or obesity, with or without BED. Design: Participants completed the Weight Efficacy Lifestyle Questionnaire, Work and Social Adjustment Scale, Worker's Perception of Environmental Factors, and a Workplace Questionnaire...
April 2018: Obesity Science & Practice
https://www.readbyqxmd.com/read/29670278/blt1-in-dendritic-cells-promotes-th1-th17-differentiation-and-its-deficiency-ameliorates-tnbs-induced-colitis
#9
Jinfeng Zhou, Weiming Lai, Wanjie Yang, Juping Pan, Hu Shen, Yingying Cai, Cuixia Yang, Ningjia Ma, Yue Zhang, Ru Zhang, Xin Xie, Zhongjun Dong, Yuan Gao, Changsheng Du
Leukotriene B4 (LTB4) synthesis is enhanced in the colonic mucosa in patients with inflammatory bowel disease (IBD). BLT1, a high-affinity receptor for LTB4, exhibits no effect on the progression of dextran sodium sulfate (DSS)-induced colitis, which mostly relies on innate immunity. Here, we reported that BLT1 regulates trinitrobenzene sulfonic acid (TNBS)-induced colitis, which reflects CD4+ T-cell-dependent adaptive immune mechanisms of IBD. We found that BLT1 signaling enhanced the progression of colitis through controlling the production of proinflammatory cytokines by dendritic cells (DCs) and modulating the differentiation of Th1 and Th17...
April 18, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29665829/effect-of-a-low-intensity-self-management-lifestyle-intervention-on-knee-pain-in-community-based-young-to-middle-aged-rural-women-a-cluster-randomised-controlled-trial
#10
Yuanyuan Wang, Catherine Lombard, Sultana Monira Hussain, Cheryce Harrison, Samantha Kozica, Sharmayne R E Brady, Helena Teede, Flavia M Cicuttini
BACKGROUND: Knee pain is common with obesity and weight gain being important risk factors. Previous clinical trials have focused on overweight or obese adults with knee pain and osteoarthritis and demonstrated modest effects of intense weight loss programs on reducing knee pain despite very significant weight loss. There has been no lifestyle intervention that targets community-based adults to test its effect on prevention of knee pain. We aimed to determine the effect of a simple low-intensity self-management lifestyle intervention (HeLP-her), proven in randomised controlled trials to improve lifestyle and prevent weight gain, on knee pain in community-based young to middle-aged rural women...
April 17, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29661944/atrial-fibrillation-burden-moving-beyond-atrial-fibrillation-as-a-binary-entity-a-scientific-statement-from-the-american-heart-association
#11
REVIEW
Lin Y Chen, Mina K Chung, Larry A Allen, Michael Ezekowitz, Karen L Furie, Pamela McCabe, Peter A Noseworthy, Marco V Perez, Mintu P Turakhia
Our understanding of the risk factors and complications of atrial fibrillation (AF) is based mostly on studies that have evaluated AF in a binary fashion (present or absent) and have not investigated AF burden. This scientific statement discusses the published literature and knowledge gaps related to methods of defining and measuring AF burden, the relationship of AF burden to cardiovascular and neurological outcomes, and the effect of lifestyle and risk factor modification on AF burden. Many studies examine outcomes by AF burden classified by AF type (paroxysmal versus nonparoxysmal); however, quantitatively, AF burden can be defined by longest duration, number of AF episodes during a monitoring period, and the proportion of time an individual is in AF during a monitoring period (expressed as a percentage)...
April 16, 2018: Circulation
https://www.readbyqxmd.com/read/29650773/cannabinoid-type-1-receptors-are-upregulated-during-acute-activation-of-brown-adipose-tissue
#12
Minna Lahesmaa, Olof Eriksson, Thorsten Gnad, Vesa Oikonen, Marco Bucci, Jussi Hirvonen, Kalle Koskensalo, Jarmo Teuho, Tarja Niemi, Markku Taittonen, Salla Lahdenpohja, Mueez U Din, Merja Haaparanta-Solin, Alexander Pfeifer, Kirsi A Virtanen, Pirjo Nuutila
Activating brown adipose tissue (BAT) could provide a potential approach for the treatment of obesity and metabolic disease in humans. Obesity is associated with up-regulation of the endocannabinoid system, and blocking the cannabinoid type 1 receptor (CB1R) has been shown to cause weight loss and decrease cardiometabolic risk factors. These effects may partly be mediated via increased BAT metabolism, since there is evidence that CB1R antagonism activates BAT in rodents. To investigate the significance of CB1R in BAT function, we quantified the density of CB1R in human and rodent BAT using the positron emission tomography (PET) radioligand [18 F]FMPEP- d 2 , and in parallel measured BAT activation with the glucose analogue [18 F]FDG...
April 12, 2018: Diabetes
https://www.readbyqxmd.com/read/29642918/the-impact-of-osteoarthritis-on-early-exit-from-work-results-from-a-population-based-study
#13
Pedro A Laires, Helena Canhão, Ana M Rodrigues, Mónica Eusébio, Miguel Gouveia, Jaime C Branco
BACKGROUND: Osteoarthritis (OA) is a leading cause of pain and disability, which may be a source of productivity losses. The objectives of this study were to describe the impact of OA, namely through pain and physical disability, on early exit from work and to calculate its economic burden. METHODS: We analysed data from the national, cross-sectional, population-based EpiReumaPt study (Sep2011-Dec2013) in which 10,661 individuals were randomly surveyed in order to capture all cases of rheumatic diseases...
April 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29628975/protective-effects-of-cultured-and-fermented-ginseng-extracts-against-scopolamine-induced-memory-loss-in-a-mouse-model
#14
Song-Hee Han, Sung-June Kim, Young Won Yun, Sang Yoon Nam, Hu-Jang Lee, Beom-Jun Lee
This study was performed to investigate the effect of a concentrate of fermented wild ginseng root culture (HLJG0701) on memory improvement in the scopolamine (SPL)-induced memory-deficient mouse model. Eight-week-old male ICR mice were used to evaluate the protective effect of HLJG0701 against the SPL-induced memory loss animal model. The Morris water maze test, which measures hippocampus-dependent learning ability, and the Y-maze test, a short-term memory assessment test, were performed and related markers were analyzed...
March 2018: Laboratory Animal Research
https://www.readbyqxmd.com/read/29627948/efficacy-of-utilizing-argon-plasma-coagulation-for-weight-regain-in-roux-en-y-gastric-bypass-patients-a-multi-center-study
#15
Rena C Moon, Andre F Teixeira, Manoel Galvao Neto, Natan Zundel, Bruno Queiroz Sander, Flavio Mitidieri Ramos, Felipe Matz, Giorgio A Baretta, Luiz Gustavo de Quadros, Eduardo Grecco, Thiago Souza, Sergio A Barrichello, Admar Concon Filho, Eduardo Nobuyuki Usuy, Artagnan Menezes Barbosa de Amorim, Muhammad A Jawad
BACKGROUND: Endoscopic approaches exist for targeting weight regain after Roux-en-Y gastric bypass (RYGB), including endoscopic suturing, clipping, and sclerotherapy. Argon plasma coagulation (APC) is a noncontact electrocoagulation method, and when used in RYGB patients, it has shown reduction in the diameter of the gastrojejunal anastomosis. OBJECTIVES: To study the effectiveness of APC for weight regain in terms of weight loss for RYGB patients, from eight bariatric centers...
April 8, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29624603/factors-associated-with-tuberculosis-treatment-delay-in-patients-co-infected-with-hiv-in-a-high-prevalence-area-in-brazil
#16
Betânia M F Nogueira, Valéria C Rolla, Kevan M Akrami, Susan M Kiene
BACKGROUND: Worldwide, about 11% of Tuberculosis (TB) cases occur in people living with HIV (PLHIV) and it is the leading cause of death in this population. An important step towards reducing the incidence and mortality of TB in PLHIV is to reduce the time from onset of symptoms to treatment. Factors related to TB treatment delay therefore need to be understood. METHODS: Using data from a prospective cohort study of patients diagnosed with TB at the National Institute of Infectious Disease, at the Oswaldo Cruz Foundation, Rio de Janeiro, Brazil we conducted a survival analysis to identify factors associated with patient and health care treatment delay...
2018: PloS One
https://www.readbyqxmd.com/read/29618203/rational-design-of-multifunctional-polymeric-nanoparticles-based-on-poly-l-histidine-and-d-%C3%AE-vitamin-e-succinate-for-reversing-tumor-multidrug-resistance
#17
Zhen Li, Qixian Chen, Yan Qi, Zhihao Liu, Tangna Hao, Xiaoxin Sun, Mingxi Qiao, Xiaodong Ma, Ting Xu, Xiuli Zhao, Chunrong Yang, Dawei Chen
A multifunctional nanoparticulate system composed of methoxy poly(ethylene glycol)-poly(L-histidine)-d-α-Vitamin E succinate (MPEG-PLH-VES) copolymers for encapsulation of doxorubicin (DOX) was elaborated with the aim of circumventing the multidrug resistance (MDR) in breast cancer treatment. The MPEG-PLH-VES nanoparticles (NPs) were subsequently functionalized with biotin motif for targeted drug delivery. The MPEG-PLH-VES copolymer exert no obvious effect on the P-gp expression level of MCF-7/ADR but exhibited a significant influence on the loss of mitochondrial membrane potential, the reduction of intracellular ATP level and the inhibition of P-gp ATPase activity of MCF-7/ADR cells...
April 4, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29617911/ontrack-development-and-feasibility-of-a-smartphone-app-designed-to-predict-and-prevent-dietary-lapses
#18
Evan M Forman, Stephanie P Goldstein, Fenqing Zhang, Brittney C Evans, Stephanie M Manasse, Meghan L Butryn, Adrienne S Juarascio, Pramod Abichandani, Gerald J Martin, Gary D Foster
Given that the overarching goal of weight loss programs is to remain adherent to a dietary prescription, specific moments of nonadherence known as "dietary lapses" can threaten weight control via the excess energy intake they represent and by provoking future lapses. Just-in-time adaptive interventions could be particularly useful in preventing dietary lapses because they use real-time data to generate interventions that are tailored and delivered at a moment computed to be of high risk for a lapse...
March 29, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29614295/methodology-and-effects-of-repeated-intranasal-delivery-of-dnsp-11-in-awake-rhesus-macaques
#19
M J Stenslik, A Evans, F Pomerleau, R Weeks, P Huettl, E Foreman, J Turchan-Cholewo, A Andersen, W A Cass, Z Zhang, R C Grondin, D M Gash, G A Gerhardt, L H Bradley
BACKGROUND: To determine if the intranasal delivery of neuroactive compounds is a viable, long-term treatment strategy for progressive, chronic neurodegenerative disorders, such as Parkinson's disease (PD), intranasal methodologies in preclinical models comparable to humans are needed. NEW METHOD: We developed a methodology to evaluate the repeated intranasal delivery of neuroactive compounds on the non-human primate (NHP) brain, without the need for sedation. We evaluated the effects of the neuroactive peptide, DNSP-11 following repeated intranasal delivery and dose-escalation over the course of 10-weeks in Rhesus macaques...
March 31, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29605008/protective-immunity-against-eimeria-maxima-induced-by-vaccines-of-em14-3-3-antigen
#20
Tingqi Liu, Jingwei Huang, Muhammad Ehsan, Shuai Wang, Hong Fei, Zhouyang Zhou, Xiaokai Song, Ruofeng Yan, Lixin Xu, Xiangrui Li
Eimeria maxima 14-3-3 (Em14-3-3) open reading frame (ORF) which consisted of 861 bp encoding a protein of 286 amino acids was successfully amplified and sequenced. Subsequently, the Em14-3-3 ORF was subcloned into pET-32a (+) and pVAX1, respectively. RT-PCR and immunoblot analyses confirmed that the target gene was successfully transcribed and expressed in vivo. Immunofluorescence analysis showed that Em14-3-3 was expressed in both the sporozoites and merozoites. The animal experiments demonstrated that both rEm14-3-3 and pVAX1-14-3-3 could clearly alleviate jejunum lesions and body weight loss...
April 15, 2018: Veterinary Parasitology
keyword
keyword
73475
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"