keyword
MENU ▼
Read by QxMD icon Read
search

targeted weight loss

keyword
https://www.readbyqxmd.com/read/29471100/dynamic-fmri-networks-predict-success-in-a-behavioral-weight-loss-program-among-older-adults
#1
Fatemeh Mokhtari, W Jack Rejeski, Yingying Zhu, Guorong Wu, Sean L Simpson, Jonathan H Burdette, Paul J Laurienti
More than one-third of adults in the United States are obese, with a higher prevalence among older adults. Obesity among older adults is a major cause of physical dysfunction, hypertension, diabetes, and coronary heart diseases. Many people who engage in lifestyle weight loss interventions fail to reach targeted goals for weight loss, and most will regain what was lost within 1-2 years following cessation of treatment. This variability in treatment efficacy suggests that there are important phenotypes predictive of success with intentional weight loss that could lead to tailored treatment regimen, an idea that is consistent with the concept of precision-based medicine...
February 19, 2018: NeuroImage
https://www.readbyqxmd.com/read/29467007/enhanced-glycolysis-contributes-to-the-pathogenesis-of-experimental-autoimmune-neuritis
#2
Ru-Tao Liu, Min Zhang, Chun-Lin Yang, Peng Zhang, Na Zhang, Tong Du, Meng-Ru Ge, Long-Tao Yue, Xiao-Li Li, Heng Li, Rui-Sheng Duan
BACKGROUND: With the recognition of the key roles of cellular metabolism in immunity, targeting metabolic pathway becomes a new strategy for autoimmune disease treatment. Guillain-Barré syndrome (GBS) is an acute immune-mediated inflammatory demyelinating disease of the peripheral nervous system, characterized by inflammatory cell infiltration. These inflammatory cells, including activated macrophages, Th1 cells, and Th17 cells, generally undergo metabolic reprogramming and rely mainly on glycolysis to exert functions...
February 21, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29466715/ovine-liver-proteome-assessing-mechanisms-of-seasonal-weight-loss-tolerance-between-merino-and-damara-sheep
#3
Blake Miller, Nathalie Selevsek, Jonas Grossman, Tanya Kilminster, Tim Scanlon, Matthew Daniels, Paolo Nanni, John Milton, Chris Oldham, Johan Greef, Aspinas Chapwanya, Don Bergfelt, André M de Almeida
The effect of feed restriction on the liver protein profiles of two different breeds of sheep was studied. We compared Merino with the Damara, breeds with respectively low and high tolerance to nutritional stress. Each breed was grouped into two nutritional treatments: restricted (12-14% loss of live weight) and control (maintenance). The trial lasted 42 days. Animals were sacrificed and liver samples subjected to label free shotgun proteomics. The resultant proteins had both their fold change and statistical significance in an unpaired t-test calculated to identify differential protein abundance...
February 18, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29463176/neuroinflammation-after-traumatic-brain-injury-tbi-is-enhanced-in-activating-transcription-factor-3-atf3-mutant-mice
#4
Philip Foerstner, Rida Rehman, Sofia Anastasiadou, Melanie Haffner-Luntzer, Daniela Sinske, Anita Ignatius, Francesco Roselli, Bernd Knoell
Traumatic brain injury (TBI) induces a neuroinflammatory response resulting in astrocyte and microglia activation at the lesion site. This involves up-regulation of neuroinflammatory genes including chemokines and interleukins. However, so far there is lack of knowledge on transcription factors (TFs) modulating this TBI associated gene expression response. Herein we analyzed activating transcription factor 3 (ATF3), a TF encoding a regeneration-associated gene (RAG) predominantly studied in peripheral nervous system (PNS) injury...
February 20, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29462213/early-detection-of-pancreatic-cancer-in-mouse-models-using-a-novel-antibody-tab004
#5
Shu-Ta Wu, Chandra D Williams, Priyanka A Grover, Laura J Moore, Pinku Mukherjee
Pancreatic ductal adenocarcinoma (PDA) is the fourth-leading cause of cancer death in the United States with a 5-year overall survival rate of 8% for all stages combined. But this decreases to 3% for the majority of patients that present with stage IV PDA at time of diagnosis. The lack of distinct early symptoms for PDA is one of the primary reasons for the late diagnosis. Common symptoms like weight loss, abdominal and back pains, and jaundice are often mistaken for symptoms of other issues and do not appear until the cancer has progressed to a late stage...
2018: PloS One
https://www.readbyqxmd.com/read/29461120/follicle-stimulating-hormone-peptide-conjugated-nanoparticles-for-targeted-shrna-delivery-lead-to-effective-gro-%C3%AE-silencing-and-antitumor-activity-against-ovarian-cancer
#6
Shan-Shan Hong, Ming-Xing Zhang, Meng Zhang, Yi Yu, Jun Chen, Xiao-Yan Zhang, Cong-Jian Xu
The distinct hormone molecules and receptors, such as follicle-stimulating hormone receptor (FSHR) in ovarian cancer, provide opportunities for more precisely targeted therapy. We previously developed FSHR-mediated nanoparticles and found that FSH peptides on the surface of nanoparticles improved the delivery of short interfering RNA (siRNA) into ovarian cancer cells. However, the high toxicity of the nanoparticles and the transient silencing of the siRNA in vivo limited further study. Here, we developed FSH peptide-conjugated nanoparticles with an increased amount of polyethylene glycol (PEG) grafting and encapsulated short hairpin RNA (shRNA) to silence the target gene, growth-regulated oncogene α (gro-α)...
February 20, 2018: Drug Delivery
https://www.readbyqxmd.com/read/29456979/quercetin-prevents-body-weight-loss-due-to-the-using-of-superparamagnetic-iron-oxide-nanoparticles-in-rat
#7
Rezvan Enteshari Najafabadi, Nasrin Kazemipour, Abolghasem Esmaeili, Siamak Beheshti, Saeed Nazifi
Background: Superparamagnetic iron oxide nanoparticles (SPION) have been largely considered for numerous applications in biomedicine such as magnetic resonance imaging, hyperthermia, cell tracking, anticancer treatment, and targeted delivery of drugs or genes. However, they may have side effects such body weight loss. Quercetin (QT), a strong antioxidant and free radical scavenger and a natural flavonoid, has a wide range of biological and therapeutic effects. In this study, the effect of QT on prevention of weight loss due to the using of SPION has been investigated...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29456420/timely-news-for-the-multidisciplinary-care-team
#8
Max Bingham
Welcome to Diabetes Spectrum 's first installment of Diabetes is Primary, a round-up of the latest diabetes developments for health care providers. In this issue, we take a look at radical weight loss for diabetes remission, Hong Kong's diabetes risk assessment and management program, personalized A1C targets, and diabetes diagnoses. The American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) panel gives its verdict on continuous glucose monitoring (CGM) devices, and we learn how Medicare will soon pay for a diabetes prevention program...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29452062/the-buddy-benefit-increasing-the-effectiveness-of-an-employee-targeted-weight-loss-program
#9
Rene Dailey, Lynsey Romo, Sarah Myer, Cathy Thomas, Surabhi Aggarwal, Kelly Nordby, Madison Johnson, Carolyn Dunn
It is well known that significant others (particularly romantic partners) can influence people's weight management efforts. However, what constitutes effective support-and from which type of individual (e.g., romantic partner, family member, friend)-is unclear. Thus, framed by confirmation theory, we assessed the effectiveness and types of communication of a weight-loss "buddy" through reports of 704 individuals enrolled in a 15-week synchronous online weight-loss program. Roughly 54% of participants chose buddies; and those who did lost more weight and waist inches than those who were involved in the program without buddy support...
February 16, 2018: Journal of Health Communication
https://www.readbyqxmd.com/read/29450848/automated-pathogenesis-based-diagnosis-of-lumbar-neural-foraminal-stenosis-via-deep-multiscale-multitask-learning
#10
Zhongyi Han, Benzheng Wei, Stephanie Leung, Ilanit Ben Nachum, David Laidley, Shuo Li
Pathogenesis-based diagnosis is a key step to prevent and control lumbar neural foraminal stenosis (LNFS). It conducts both early diagnosis and comprehensive assessment by drawing crucial pathological links between pathogenic factors and LNFS. Automated pathogenesis-based diagnosis would simultaneously localize and grade multiple spinal organs (neural foramina, vertebrae, intervertebral discs) to diagnose LNFS and discover pathogenic factors. The automated way facilitates planning optimal therapeutic schedules and relieving clinicians from laborious workloads...
February 15, 2018: Neuroinformatics
https://www.readbyqxmd.com/read/29447812/total-serum-bilirubin-levels-and-sensorineural-hearing-loss-in-the-us-adolescents-nhanes-2007-2010
#11
Guoli Zhou, Wenjiang Fu
OBJECTIVE: We aimed to investigate whether current levels of total serum bilirubin are associated with different subtypes of sensorineural hearing loss (SNHL) in adolescents. METHODS: A set of cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) (2007-2010) was used. A subset of 1404 adolescents was sampled for measurements of total serum bilirubin, tympanometry, and average pure tone threshold at low-frequencies (LPTA: 500, 1000, 2000 Hz) or high-frequencies (HPTA: 3000, 4000, 6000, and 8000 Hz)...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29446541/group-based-diet-and-physical-activity-weight-loss-interventions-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#12
Aleksandra J Borek, Charles Abraham, Colin J Greaves, Mark Tarrant
BACKGROUND: Many weight-loss interventions are delivered in groups but evidence on their effectiveness, and characteristics associated with effectiveness, is limited. We synthesised evidence on (1) design and delivery of group-based weight-loss interventions; (2) effectiveness; and (3) associations between intervention characteristics, change techniques, and effectiveness. METHODS: Five online databases were searched to May 2017 for randomised controlled trials (RCTs) of group-based diet and/or physical activity interventions for overweight/obese adults (BMI ≥ 25)...
February 15, 2018: Applied Psychology. Health and Well-being
https://www.readbyqxmd.com/read/29446146/crispr-cas9-mediated-mstn-disruption-and-heritable-mutagenesis-in-goats-causes-increased-body-mass
#13
X Wang, Y Niu, J Zhou, H Zhu, B Ma, H Yu, H Yan, J Hua, X Huang, L Qu, Y Chen
Genetic engineering in livestock has been greatly enhanced through the use of artificial programmed nucleases such as the recently emerged clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) system. We recently reported our successful application of the CRISPR/Cas9 system to engineer the goat genome through micro-injection of Cas9 mRNA and sgRNAs targeting MSTN and FGF5 in goat embryos. The phenotypes induced by edited loss-of-function mutations of MSTN remain to be evaluated extensively...
February 2018: Animal Genetics
https://www.readbyqxmd.com/read/29440899/aptamer-drug-conjugate-targeted-delivery-of-doxorubicin-in-a-her3-aptamer-functionalized-liposomal-delivery-system-reduces-cardiotoxicity
#14
Xiao-Qian Dou, Hua Wang, Jing Zhang, Fang Wang, Gui-Li Xu, Cheng-Cheng Xu, Huan-Hua Xu, Shen-Si Xiang, Jie Fu, Hai-Feng Song
Introduction: The toxic side effects of doxorubicin (DOX) have limited its use in chemotherapy. Neither liposomal DOX nor pegylated liposomal DOX are able to completely resolve this issue. This is a proof-of-concept study testing aptamer-drug conjugate (ApDC) targeted delivery systems for chemotherapeutic drugs. Methods: Aptamer library targeting human epidermal growth factor receptor 3 (HER3) was screened and affinity was determined by enzyme-linked immunosorbent assay...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29440419/epitope-specific-monoclonal-antibodies-to-fsh%C3%AE-increase-bone-mass
#15
Yaoting Ji, Peng Liu, Tony Yuen, Shozeb Haider, Jiahuan He, Raquel Romero, Hao Chen, Madison Bloch, Se-Min Kim, Daria Lizneva, Lubna Munshi, Chunxue Zhou, Ping Lu, Jameel Iqbal, Zhen Cheng, Maria I New, Aaron J Hsueh, Zhuan Bian, Clifford J Rosen, Li Sun, Mone Zaidi
Pituitary hormones have long been thought solely to regulate single targets. Challenging this paradigm, we discovered that both anterior and posterior pituitary hormones, including FSH, had other functions in physiology. We have shown that FSH regulates skeletal integrity, and, more recently, find that FSH inhibition reduces body fat and induces thermogenic adipose tissue. A polyclonal antibody raised against a short, receptor-binding epitope of FSHβ was found not only to rescue bone loss postovariectomy, but also to display marked antiobesity and probeiging actions...
February 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29434226/detection-of-multi-tomato-leaf-diseases-late-blight-target-and-bacterial-spots-in-different-stages-by-using-a-spectral-based-sensor
#16
Jinzhu Lu, Reza Ehsani, Yeyin Shi, Ana Isabel de Castro, Shuang Wang
Several diseases have threatened tomato production in Florida, resulting in large losses, especially in fresh markets. In this study, a high-resolution portable spectral sensor was used to investigate the feasibility of detecting multi-diseased tomato leaves in different stages, including early or asymptomatic stages. One healthy leaf and three diseased tomato leaves (late blight, target and bacterial spots) were defined into four stages (healthy, asymptomatic, early stage and late stage) and collected from a field...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29425906/effects-of-vagal-neuromodulation-on-feeding-behavior
#17
Nicole A Pelot, Warren M Grill
Implanted vagus nerve stimulation (VNS) for obesity was recently approved by the FDA. However, its efficacy and mechanisms of action remain unclear. Herein, we synthesize clinical and preclinical effects of VNS on feeding behavior and energy balance and discuss engineering considerations for understanding and improving the therapy. Clinical cervical VNS (≤30 Hz) to treat epilepsy or depression has produced mixed effects on weight loss as a side effect, albeit in uncontrolled, retrospective studies. Conversely, preclinical studies (cervical and subdiaphragmatic VNS) mostly report decreased food intake and either decreased weight gain or weight loss...
February 6, 2018: Brain Research
https://www.readbyqxmd.com/read/29425636/computerised-decision-support-in-physical-activity-interventions-a-systematic-literature-review
#18
REVIEW
Andreas Triantafyllidis, Dimitris Filos, Jomme Claes, Roselien Buys, Véronique Cornelissen, Evangelia Kouidi, Ioanna Chouvarda, Nicos Maglaveras
BACKGROUND: The benefits of regular physical activity for health and quality of life are unarguable. New information, sensing and communication technologies have the potential to play a critical role in computerised decision support and coaching for physical activity. OBJECTIVES: We provide a literature review of recent research in the development of physical activity interventions employing computerised decision support, their feasibility and effectiveness in healthy and diseased individuals, and map out challenges and future research directions...
March 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29423679/predictors-of-enrollment-in-individual-and-couple-based-lifestyle-intervention-trials-for-cancer-survivors
#19
Emily Cox-Martin, Jaejoon Song, Wendy Demark-Wahnefried, Elizabeth J Lyons, Karen Basen-Engquist
PURPOSE: To utilize data from lifestyle intervention pilot studies for cancer survivors to elucidate demographic, disease-related, and health behavior factors that might predict enrollment in this type of research. Additionally, factors were differentially compared based on intervention design (i.e., individual versus couple-based). METHODS: Secondary data analysis was conducted regarding predictors of enrollment into lifestyle intervention studies, including Healthy Moves Weight Loss (individual participants, screened n = 89, enrolled n = 30) and Healthy Moves Couples (survivors and their partners, screened n = 197, enrolled n = 23)...
February 8, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29423556/psychosocial-predictors-of-change-in-depressive-symptoms-following-gastric-banding-surgery
#20
Kymberlie Preiss, David Clarke, Paul O'Brien, Xochitl de la Piedad Garcia, Annemarie Hindle, Leah Brennan
OBJECTIVE: The aim of this study is to identify psychosocial variables associated with the relationship between weight loss and change in depressive symptoms following gastric banding surgery. METHODS: Ninety-nine adults completed self-report questionnaires assessing depressive symptoms and other psychosocial variables (self-esteem, body image dissatisfaction, perceived physical health, and perceived weight-based stigmatisation) prior to gastric-band surgery and monthly for 6-month post-surgery...
February 8, 2018: Obesity Surgery
keyword
keyword
73475
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"