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https://www.readbyqxmd.com/read/28103255/mitigating-diseases-transmitted-by-aedes-mosquitoes-a-cluster-randomised-trial-of-permethrin-impregnated-school-uniforms
#1
Pattamaporn Kittayapong, Phanthip Olanratmanee, Pongsri Maskhao, Peter Byass, James Logan, Yesim Tozan, Valérie Louis, Duane J Gubler, Annelies Wilder-Smith
BACKGROUND: Viral diseases transmitted via Aedes mosquitoes are on the rise, such as Zika, dengue, and chikungunya. Novel tools to mitigate Aedes mosquitoes-transmitted diseases are urgently needed. We tested whether commercially insecticide-impregnated school uniforms can reduce dengue incidence in school children. METHODS: We designed a cluster-randomised controlled trial in Thailand. The primary endpoint was laboratory-confirmed dengue infections. Secondary endpoints were school absenteeism; and impregnated uniforms' 1-hour knock-down and 24 hour mosquito mortality as measured by standardised WHOPES bioassay cone tests at baseline and after repeated washing...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28062794/larvicidal-and-growth-inhibitory-activity-of-entomopathogenic-bacteria-culture-fluids-against-aedes-aegypti-diptera-culicidae
#2
João Luiz Rosa da Silva, Fernanda Undurraga Schwalm, Carlos Eugênio Silva, Marisa da Costa, Ralf Heermann, Onilda Santos da Silva
Dengue, Chikungunya, and Zika are important vector-borne diseases, and Aedes aegypti L. is their main transmitter. As the disease management is mainly based on mosquito control strategies, the search for alternative and cost-effective approaches is ongoing. The Gram-negative bacteria Xenorhabdus nematophila and Photorhabdus luminescens are symbiotically associated with entomopathogenic nematodes and are highly pathogenic for insect larvae. After we have recently confirmed the toxicity of these bacteria in Ae...
January 6, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28062078/-coexistence-of-acute-appendicitis-and-dengue-fever-a-case-report
#3
Juan Fidel Osuna-Ramos, Carlos Silva-Gracia, Gerardo Joel Maya-Vacio, Alejandra Romero-Utrilla, Efrén Rafael Ríos-Burgueño, Jesús Salvador Velarde-Félix
BACKGROUND: Dengue is the most important human viral disease transmitted by mosquitoes. It can be asymptomatic or it can present in any of its 3clinical forms: Dengue fever, dengue haemorrhagic fever and dengue shock syndrome. However, some atypical manifestations have been reported in surgical emergencies caused by acute appendicitis in patients with dengue fever. CLINICAL CASE: We report the case of an 18-year-old Mexican male who presented to the emergency department of the General Hospital of Culiacan, Sinaloa, with symptoms of dengue fever, accompanied by crampy abdominal pain with positive Rovsing and Dunphy signs...
January 3, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28031723/economic-report-on-the-cost-of-dengue-fever-in-vietnam-case-of-a-provincial-hospital
#4
Luyen Dinh Pham, Nhat Huy Tran Phung, Nguyen Tu Dang Le, Trung Quang Vo
BACKGROUND: Dengue is a mosquito-borne viral illness with the world's fastest rate of infection. In 2014, Vietnam had recorded 43,000 cases in 53 provinces, with 28 deaths. MATERIALS AND METHODS: A 6-month cross-sectional study was conducted from September 2015 to March 2016 at Cu Chi General Hospital. Cost of illness in this study was estimated under the incidence-based approach from the societal perspective. RESULTS: The average cost per case was US$139...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28030537/molecular-virologic-and-clinical-characteristics-of-a-chikungunya-fever-outbreak-in-la-romana-dominican-republic-2014
#5
Rose M Langsjoen, Rebecca J Rubinstein, Tiffany F Kautz, Albert J Auguste, Jesse H Erasmus, Liddy Kiaty-Figueroa, Renessa Gerhardt, David Lin, Kumar L Hari, Ravi Jain, Nicolas Ruiz, Antonio E Muruato, Jael Silfa, Franklin Bido, Matthew Dacso, Scott C Weaver
Since emerging in Saint Martin in 2013, chikungunya virus (CHIKV), an alphavirus transmitted by the Aedes aegypti mosquito, has infected approximately two million individuals in the Americas, with over 500,000 reported cases in the Dominican Republic (DR). CHIKV-infected patients typically present with a febrile syndrome including polyarthritis/polyarthralgia, and a macropapular rash, similar to those infected with dengue and Zika viruses, and malaria. Nevertheless, many Dominican cases are unconfirmed due to the unavailability and high cost of laboratory testing and the absence of specific treatment for CHIKV infection...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28011234/epidemic-arboviral-diseases-priorities-for-research-and-public-health
#6
REVIEW
Annelies Wilder-Smith, Duane J Gubler, Scott C Weaver, Thomas P Monath, David L Heymann, Thomas W Scott
For decades, arboviral diseases were considered to be only minor contributors to global mortality and disability. As a result, low priority was given to arbovirus research investment and related public health infrastructure. The past five decades, however, have seen an unprecedented emergence of epidemic arboviral diseases (notably dengue, chikungunya, yellow fever, and Zika virus disease) resulting from the triad of the modern world: urbanisation, globalisation, and international mobility. The public health emergency of Zika virus, and the threat of global spread of yellow fever, combined with the resurgence of dengue and chikungunya, constitute a wake-up call for governments, academia, funders, and WHO to strengthen programmes and enhance research in aedes-transmitted diseases...
December 20, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27993003/nanoarchitecture-based-sers-for-biomolecular-fingerprinting-and-label-free-disease-markers-diagnosis
#7
Sudarson Sekhar Sinha, Stacy Jones, Avijit Pramanik, Paresh Chandra Ray
Surface-enhanced Raman spectroscopy (SERS) fingerprinting is highly promising for identifying disease markers from complex mixtures of clinical sample, which has the capability to take medical diagnoses to the next level. Although vibrational frequency in Raman spectra is unique for each biomolecule, which can be used as fingerprint identification, it has not been considered to be used routinely for biosensing due to the fact that the Raman signal is very weak. Contemporary SERS has been demonstrated to be an excellent analytical tool for practical label-free sensing applications due its ability to enhance Raman signals by factors of up to 10(8)-10(14) orders of magnitude...
December 20, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27982076/establishment-of-the-cytoplasmic-incompatibility-inducing-wolbachia-strain-wmel-in-an-important-agricultural-pest-insect
#8
Xiao-Fei Zhou, Zheng-Xi Li
The wMel Wolbachia strain was known for cytoplasmic incompatibility (CI)-induction and blocking the transmission of dengue. However, it is unknown whether it can establish and induce CI in a non-dipteran host insect. Here we artificially transferred wMel from Drosophila melanogaster into the whitefly Bemisia tabaci. Fluorescence in situ hybridisation demonstrated that wMel had successfully transfected the new host. Reciprocal crossing was conducted with wMel-transfected and wild-type isofemale lines, indicating that wMel could induce a strong CI without imposing significant cost on host fecundity...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27970796/cost-of-dengue-illness-and-cost-effectiveness-of-the-cdy-tdv-dengue-vaccine-in-ecuador
#9
R Lucio-Romero, A R Henriquez-Trujillo, K Bermudez-Gallegos, B Tello-Ponce, A G Caicedo Navas, C Vandeputte
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970789/cost-effective-analysis-of-the-dengue-vaccine-in-costa-rica
#10
Y Xirinachs
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970785/cost-of-dengue-and-cost-effectiveness-of-the-dengue-vaccine-in-panama
#11
L N Garcia, L Cerezo, A Blas, S Alvarez, N Quiroz, A G Caicedo Navas, J G Lopez, C Vandeputte
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27955870/evaluation-of-a-pan-serotype-point-of-care-rapid-diagnostic-assay-for-accurate-detection-of-acute-dengue-infection
#12
Rosario Vivek, Syed Fazil Ahamed, Shalini Kotabagi, Anmol Chandele, Ira Khanna, Navin Khanna, Kaustuv Nayak, Mary Dias, Murali-Krishna Kaja, Anita Shet
The catastrophic rise in dengue infections in India and globally has created a need for an accurate, validated low-cost rapid diagnostic test (RDT) for dengue. We prospectively evaluated the diagnostic performance of NS1/IgM RDT (dengue day 1) using 211 samples from a pediatric dengue cohort representing all 4 serotypes in southern India. The dengue-positive panel consisted of 179 dengue real-time polymerase chain reaction (RT-PCR) positive samples from symptomatic children. The dengue-negative panel consisted of 32 samples from dengue-negative febrile children and asymptomatic individuals that were negative for dengue RT-PCR/NS1 enzyme-linked immunosorbent assay/IgM/IgG...
September 30, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27934884/rapid-affordable-and-portable-medium-throughput-molecular-device-for-zika-virus
#13
Kamfai Chan, Scott C Weaver, Pui-Yan Wong, Sherly Lie, Eryu Wang, Mathilde Guerbois, Siva Praneeth Vayugundla, Season Wong
Zika virus (ZIKV) has gained global attention as an etiologic agent of fetal microcephaly and Guillain-Barré syndrome. Existing immuno-based rapid tests often fail to distinguish between Zika and related flaviviruses that are common in affected regions of Central and South Americas and the Caribbean. The US CDC and qualified state health department laboratories can perform the reverse transcription polymerase chain reaction (RT-PCR) ZIKV test using highly sophisticated instruments with long turnaround times...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924792/a-cost-effective-approach-to-the-diagnosis-and-management-of-acute-infectious-encephalitis
#14
Usha Kant Misra, Vinita Elizabeth Mani, Jayantee Kalita
SETTING: A tertiary care teaching hospital in India. OBJECTIVE: To report a syndromic approach to acute encephalitis syndrome (AES) and propose a cost-effective model. STUDY DESIGN: AES patients were categorized by the presence or absence of myalgia/rash into systemic and neurological AES. The patients with systemic AES were investigated for dengue, scrub typhus, leptospira, chikungunya, and malaria, and those with neurological AES were investigated for herpes and Japanese encephalitis (JE)...
2017: European Neurology
https://www.readbyqxmd.com/read/27908746/willingness-to-pay-for-a-dengue-vaccine-and-its-associated-determinants-in-indonesia-a-community-based-cross-sectional-survey-in-aceh
#15
Harapan Harapan, Samsul Anwar, Aslam Bustamam, Arsil Radiansyah, Pradiba Angraini, Riny Fasli, Salwiyadi Salwiyadi, Reza Akbar Bastian, Ade Oktiviyari, Imaduddin Akmal, Muhammad Iqbalamin, Jamalul Adil, Fenni Henrizal, Darmayanti Darmayanti, Mahmuda Mahmuda, Mudatsir Mudatsir, Allison Imrie, R Tedjo Sasmono, Ulrich Kuch, Ziv Shkedy, Setia Pramana
Vaccination strategies are being considered as a part of dengue prevention programs in endemic countries. To accelerate the introduction of dengue vaccine into the public sector program and private markets, understanding the private economic benefits of a dengue vaccine is therefore essential. The aim of this study was to assess the willingness to pay (WTP) for a dengue vaccine among community members in Indonesia and its associated explanatory variables. A community-based, cross-sectional survey was conducted in nine regencies of Aceh province, Indonesia, from November 2014 to March 2015...
February 2017: Acta Tropica
https://www.readbyqxmd.com/read/27905501/using-baidu-search-index-to-predict-dengue-outbreak-in-china
#16
Kangkang Liu, Tao Wang, Zhicong Yang, Xiaodong Huang, Gabriel J Milinovich, Yi Lu, Qinlong Jing, Yao Xia, Zhengyang Zhao, Yang Yang, Shilu Tong, Wenbiao Hu, Jiahai Lu
This study identified the possible threshold to predict dengue fever (DF) outbreaks using Baidu Search Index (BSI). Time-series classification and regression tree models based on BSI were used to develop a predictive model for DF outbreak in Guangzhou and Zhongshan, China. In the regression tree models, the mean autochthonous DF incidence rate increased approximately 30-fold in Guangzhou when the weekly BSI for DF at the lagged moving average of 1-3 weeks was more than 382. When the weekly BSI for DF at the lagged moving average of 1-5 weeks was more than 91...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27898668/the-long-term-safety-public-health-impact-and-cost-effectiveness-of-routine-vaccination-with-a-recombinant-live-attenuated-dengue-vaccine-dengvaxia-a-model-comparison-study
#17
Stefan Flasche, Mark Jit, Isabel Rodríguez-Barraquer, Laurent Coudeville, Mario Recker, Katia Koelle, George Milne, Thomas J Hladish, T Alex Perkins, Derek A T Cummings, Ilaria Dorigatti, Daniel J Laydon, Guido España, Joel Kelso, Ira Longini, Jose Lourenco, Carl A B Pearson, Robert C Reiner, Luis Mier-Y-Terán-Romero, Kirsten Vannice, Neil Ferguson
BACKGROUND: Large Phase III trials across Asia and Latin America have recently demonstrated the efficacy of a recombinant, live-attenuated dengue vaccine (Dengvaxia) over the first 25 mo following vaccination. Subsequent data collected in the longer-term follow-up phase, however, have raised concerns about a potential increase in hospitalization risk of subsequent dengue infections, in particular among young, dengue-naïve vaccinees. We here report predictions from eight independent modelling groups on the long-term safety, public health impact, and cost-effectiveness of routine vaccination with Dengvaxia in a range of transmission settings, as characterised by seroprevalence levels among 9-y-olds (SP9)...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27888023/integrated-process-for-the-purification-and-immobilization-of-the-envelope-protein-domain-iii-of-dengue-virus-type-2-expressed-in-rachiplusia-nu-larvae-and-its-potential-application-in-a-diagnostic-assay
#18
María Emilia Smith, Alexandra Marisa Targovnik, Julieta Cerezo, María Alejandra Morales, María Victoria Miranda, Julián Rodríguez Talou
Dengue incidence has grown dramatically in the last years, with about 40% of the world population at risk of infection. Recently, a vaccine developed by Sanofi Pasteur has been registered, but only in a few countries. Moreover, specific antiviral drugs are not available. Thus, an efficient and accurate diagnosis is important for disease management. To develop a low-cost immunoassay for dengue diagnosis, in the present study we expressed the envelope protein domain III of dengue virus type 2 in Rachiplusia nu larvae by infection with a recombinant baculovirus...
November 23, 2016: Protein Expression and Purification
https://www.readbyqxmd.com/read/27870689/zika-virus-and-diagnostics
#19
Claudia Raja Gabaglia
PURPOSE OF REVIEW: The purpose of this review is to present what is known about the Zika virus (ZIKV) at the time of writing this review. The viral structure and its phylogeny, as well as the limitations of current available techniques used for diagnosis, are discussed. RECENT FINDINGS: Crystallography and cryo-electron microscopy of the whole ZIKV, or a few of its proteins, are confirming its overall antigenic relatedness to other flaviviruses. Sequencing has revealed its dynamic genetic variation and has placed the Western cluster of Zika isolates within the Asian phylogenic tree...
February 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/27869956/-aedes-aegypti-control-strategies-a-review
#20
Ana Laura de Sene Amâncio Zara, Sandra Maria Dos Santos, Ellen Synthia Fernandes-Oliveira, Roberta Gomes Carvalho, Giovanini Evelim Coelho
OBJECTIVE: to describe the main strategies to control Aedes aegypti, with emphasis on promising technological innovations for use in Brazil. METHODS: this study is a non-systematic review of the literature. Results: several technologies have been developed as alternatives in the control of Ae. aegypti, using different mechanisms of action, such as selective monitoring of the infestation, social interventions, dispersing insecticides, new biological control agents and molecular techniques for population control of mosquitoes, also considering the combination between them...
April 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
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