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https://www.readbyqxmd.com/read/28722613/why-did-zika-not-explode-in-cuba-the-role-of-active-community-participation-to-sustain-control-of-vector-borne-diseases
#1
Marta Castro, Dennis Perez, Maria G Guzman, Clare Barrington
As the global public health community develops strategies for sustainable Zika prevention and control, assessment of the Cuban response to Zika provides critical lessons learned. Cuba's early and successful response to Zika, grounded in the country's long-standing dengue prevention and control program, serves as a model of rapid mobilization of intersectoral efforts. Sustaining this response requires applying the evidence generated within the Cuban dengue program that active community participation improves outcomes and is sustainable and cost-effective...
June 19, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719659/dengue-prediction-by-the-web-tweets-are-a-useful-tool-for-estimating-and-forecasting-dengue-at-country-and-city-level
#2
Cecilia de Almeida Marques-Toledo, Carolin Marlen Degener, Livia Vinhal, Giovanini Coelho, Wagner Meira, Claudia Torres Codeço, Mauro Martins Teixeira
BACKGROUND: Infectious diseases are a leading threat to public health. Accurate and timely monitoring of disease risk and progress can reduce their impact. Mentioning a disease in social networks is correlated with physician visits by patients, and can be used to estimate disease activity. Dengue is the fastest growing mosquito-borne viral disease, with an estimated annual incidence of 390 million infections, of which 96 million manifest clinically. Dengue burden is likely to increase in the future owing to trends toward increased urbanization, scarce water supplies and, possibly, environmental change...
July 18, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28716913/antibody-based-assay-discriminates-zika-virus-infection-from-other-flaviviruses
#3
Angel Balmaseda, Karin Stettler, Raquel Medialdea-Carrera, Damaris Collado, Xia Jin, José Victor Zambrana, Stefano Jaconi, Elisabetta Cameroni, Saira Saborio, Francesca Rovida, Elena Percivalle, Samreen Ijaz, Steve Dicks, Ines Ushiro-Lumb, Luisa Barzon, Patricia Siqueira, David W G Brown, Fausto Baldanti, Richard Tedder, Maria Zambon, A M Bispo de Filippis, Eva Harris, Davide Corti
Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged recently as a global health threat, causing a pandemic in the Americas. ZIKV infection mostly causes mild disease, but is linked to devastating congenital birth defects and Guillain-Barré syndrome in adults. The high level of cross-reactivity among flaviviruses and their cocirculation has complicated serological approaches to differentially detect ZIKV and dengue virus (DENV) infections, accentuating the urgent need for a specific and sensitive serological test...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28701194/characterization-and-productivity-profiles-of-aedes-aegypti-l-breeding-habitats-across-rural-and-urban-landscapes-in-western-and-coastal-kenya
#4
Harun N Ngugi, Francis M Mutuku, Bryson A Ndenga, Peter S Musunzaji, Joel O Mbakaya, Peter Aswani, Lucy W Irungu, Dunstan Mukoko, John Vulule, Uriel Kitron, Angelle D LaBeaud
BACKGROUND: Aedes aegypti, the principal vector for dengue and other emerging arboviruses, breeds preferentially in various man-made and natural container habitats. In the absence of vaccine, epidemiological surveillance and vector control remain the best practices for preventing dengue outbreaks. Effective vector control depends on a good understanding of larval and adult vector ecology of which little is known in Kenya. In the current study, we sought to characterize breeding habitats and establish container productivity profiles of Ae...
July 12, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28699565/household-costs-of-dengue-illness-secondary-outcomes-from-a-randomised-controlled-trial-of-dengue-prevention-in-guerrero-state-mexico
#5
José Legorreta-Soberanis, Sergio Paredes-Solís, Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, Felipe René Serrano-de Los Santos, Diana Lisseth Dimas-Garcia, Robert J Ledogar, Anne Cockcroft, Neil Andersson
BACKGROUND: Dengue is a serious public health problem with an important economic impact. This study used data from a cluster randomised controlled trial of community mobilisation for dengue prevention to estimate the household costs of treatment of dengue illness. It examined the economic impact of the trial intervention in the three coastal regions of Mexico's Guerrero State. METHODS: The 2010 baseline survey covered households in a random sample of 90 clusters in the coastal regions; the clusters were randomly allocated to intervention or control and re-surveyed in 2012...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699561/mobilising-communities-for-aedes-aegypti-control-the-sepa-approach
#6
REVIEW
Robert J Ledogar, Jorge Arosteguí, Carlos Hernández-Alvarez, Arcadio Morales-Perez, Elizabeth Nava-Aguilera, José Legorreta-Soberanis, Harold Suazo-Laguna, Alejandro Belli, Jorge Laucirica, Josefina Coloma, Eva Harris, Neil Andersson
Camino Verde (the Green Way) is an evidence-based community mobilisation tool for prevention of dengue and other mosquito-borne viral diseases. Its effectiveness was demonstrated in a cluster-randomised controlled trial conducted in 2010-2013 in Nicaragua and Mexico. The common approach that brought functional consistency to the Camino Verde intervention in both Mexico and Nicaragua is Socialisation of Evidence for Participatory Action (SEPA). In this article, we explain the SEPA concept and its theoretical origins, giving examples of its previous application in different countries and contexts...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699551/the-camino-verde-intervention-in-nicaragua-2004-2012
#7
REVIEW
Jorge Arosteguí, Robert J Ledogar, Josefina Coloma, Carlos Hernández-Alvarez, Harold Suazo-Laguna, Alvaro Cárcamo, Rosa María Reyes, Alejandro Belli, Neil Andersson, Eva Harris
Camino Verde (the Green Way) is an evidence-based community mobilisation tool for prevention of dengue and other mosquito-borne viral diseases. Its effectiveness was demonstrated in a cluster-randomised controlled trial conducted in 2010-2013 in Nicaragua and Mexico. The Nicaraguan arm of the trial was preceded, from 2004 to 2008, by a feasibility study that provided valuable lessons and trained facilitators for the trial itself. Here, guided by the Template for Intervention Description and Replication (TIDieR), we describe the Camino Verde intervention in Nicaragua, presenting its rationale, its time and location, activities, materials used, the main actors, modes of delivery, how it was tailored to encourage community engagement, modifications made from the feasibility study to the trial itself, and how fidelity to the process originally designed was maintained...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699550/household-costs-for-personal-protection-against-mosquitoes-secondary-outcomes-from-a-randomised-controlled-trial-of-dengue-prevention-in-guerrero-state-mexico
#8
José Legorreta-Soberanis, Sergio Paredes-Solís, Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, Felipe René Serrano-de Los Santos, Belén Madeline Sánchez-Gervacio, Robert J Ledogar, Anne Cockcroft, Neil Andersson
BACKGROUND: Dengue is a serious public health issue that affects households in endemic areas in terms of health and also economically, imposing costs for prevention and treatment of cases. The Camino Verde cluster-randomised controlled trial in Mexico and Nicaragua assessed the impact of evidence-based community engagement in dengue prevention. The Mexican arm of the trial was conducted in 90 randomly selected communities in three coastal regions of Guerrero State. This study reports an analysis of a secondary outcome of the trial: household use of and expenditure on anti-mosquito products...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699548/when-communities-are-really-in-control-ethical-issues-surrounding-community-mobilisation-for-dengue-prevention-in-mexico-and-nicaragua
#9
REVIEW
Robert J Ledogar, Carlos Hernández-Alvarez, Amy C Morrison, Jorge Arosteguí, Arcadio Morales-Perez, Elizabeth Nava-Aguilera, José Legorreta-Soberanis, Dawn Caldwell, Josefina Coloma, Eva Harris, Neil Andersson
We discuss two ethical issues raised by Camino Verde, a 2011-2012 cluster-randomised controlled trial in Mexico and Nicaragua, that reduced dengue risk though community mobilisation. The issues arise from the approach adopted by the intervention, one called Socialisation of Evidence for Participatory Action. Community volunteer teams informed householders of evidence about dengue, its costs and the life-cycle of Aedes aegypti mosquitoes, while showing them the mosquito larvae in their own water receptacles, without prescribing solutions...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699542/community-cost-benefit-discussions-that-launched-the-camino-verde-intervention-in-nicaragua
#10
Carlos Hernandez-Alvarez, Jorge Arosteguí, Harold Suazo-Laguna, Rosa Maria Reyes, Josefina Coloma, Eva Harris, Neil Andersson, Robert J Ledogar
BACKGROUND: Recent literature on community intervention research stresses system change as a condition for durable impact. This involves highly participatory social processes leading to behavioural change. METHODS: Before launching the intervention in the Nicaraguan arm of Camino Verde, a cluster-randomised controlled trial to show that pesticide-free community mobilisation adds effectiveness to conventional dengue controls, we held structured discussions with leaders of intervention communities on costs of dengue illness and dengue control measures taken by both government and households...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699541/randomised-controlled-trials-and-changing-public-health-practice
#11
EDITORIAL
Anne Cockcroft
One reason for doing randomised controlled trials (RCTs) is that experiments can be convincing. Early epidemiological experimenters, such as Jenner and the smallpox vaccine and Snow and his famous Broad Street pump handle, already knew the answer they were demonstrating; they used the experiments as knowledge translation devices to convince others.More sophisticated modern experiments include cluster randomised controlled trials (CRCTs) for experiments in the public health setting. The knowledge translation value remains: RCTs and CRCTs can potentially stimulate changes of practice among stakeholders...
May 30, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28683119/the-socio-economic-burden-of-snakebite-in-sri-lanka
#12
Anuradhani Kasturiratne, Arunasalam Pathmeswaran, A Rajitha Wickremasinghe, Shaluka F Jayamanne, Andrew Dawson, Geoff K Isbister, Hithanadura Janaka de Silva, David G Lalloo
BACKGROUND: Snakebite is a major problem affecting the rural poor in many of the poorest countries in the tropics. However, the scale of the socio-economic burden has rarely been studied. We undertook a comprehensive assessment of the burden in Sri Lanka. METHODS: Data from a representative nation-wide community based household survey were used to estimate the number of bites and deaths nationally, and household and out of pocket costs were derived from household questionnaires...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28638764/small-molecule-dengue-virus-co-imprinting-and-its-application-as-an-electrochemical-sensor
#13
Wannisa Sukjee, Chompoonuch Tancharoen, Pa-Thai Yenchitsomanus, M Paul Gleeson, Chak Sangma
Polymers can be synthesized to recognize small molecules. This is achieved by introducing the target molecule during monomer self-assembly, where they can be incorporated during cross-linking polymerization. Following additional pre-processing, the material obtained can then be applied as a sensing layer for these molecules in many applications. The sensitivity of the polymers depends on the "active sites" imprinted on the surface. Increasing the number of active sites on the polymers surface can be achieved by using nanoparticles as a platform to support and concentrate the molecules for imprinting...
June 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28636445/developing-a-casper-survey-to-assess-the-prevalence-of-risk-factors-for-neglected-tropical-diseases-in-texas
#14
Seth Smitherman, Tracy Hammond, Daniel Goldberg, Jennifer Horney
While more than a billion people live at risk of neglected tropical diseases in areas of Asia, sub-Saharan Africa, and Latin America, the degree to which such diseases burden countries like the United States is currently unclear. Even though many neglected tropical diseases such as dengue, leishmaniasis, and Chagas disease are not endemic to the United States, the possibility of their emergence is noteworthy, especially in states like Texas, which has high levels of poverty, a large immigrant population, and a climate amenable to the vectors for these diseases and is geographically proximate to endemic areas...
May 2017: Health Security
https://www.readbyqxmd.com/read/28583207/knockdown-resistance-kdr-of-the-voltage-gated-sodium-channel-gene-of-aedes-aegypti-population-in-denpasar-bali-indonesia
#15
Penny Humaidah Hamid, Joko Prastowo, Anis Widyasari, Anja Taubert, Carlos Hermosilla
BACKGROUND: Aedes aegypti is the main vector of several arthropod-borne viral infections in the tropics profoundly affecting humans, such as dengue fever (DF), West Nile (WN), chikungunya and more recently Zika. Eradication of Aedes still largely depends on insecticides, which is the most cost-effective strategy, and often inefficient due to resistance development in exposed Aedes populations. We here conducted a study of Ae. aegypti resistance towards several insecticides regularly used in the city of Denpasar, Bali, Indonesia...
June 5, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28560654/newer-vaccines-against-mosquito-borne-diseases
#16
Anju Aggarwal, Neha Garg
Mosquitos are responsible for a number of protozoal and viral diseases. Malaria, dengue, Japanese encephalitis (JE) and chikungunya epidemics occur commonly all over the world, leading to marked mortality and morbidity in children. Zika, Yellow fever and West Nile fever are others requiring prevention. Environmental control and mosquito bite prevention are useful in decreasing the burden of disease but vaccination has been found to be most cost-effective and is the need of the hour. RTS,S/AS01 vaccine is the first malaria vaccine being licensed for use against P...
May 31, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28553618/effective-protection-induced-by-a-monovalent-dna-vaccine-against-dengue-virus-dv-serotype-1-and-a-bivalent-dna-vaccine-against-dv1-and-dv2-in-mice
#17
Xiaoyan Zheng, Hui Chen, Ran Wang, Dongying Fan, Kaihao Feng, Na Gao, Jing An
Dengue virus (DV) is the causal pathogen of dengue fever, which is one of the most rapidly spread mosquito-borne disease worldwide and has become a severe public health problem. Currently, there is no specific treatment for dengue; thus, a vaccine would be an effective countermeasure to reduce the morbidity and mortality. Although, the chimeric Yellow fever dengue tetravalent vaccine has been approved in some countries, it is still necessary to develop safer, more effective, and less costly vaccines. In this study, a DNA vaccine candidate pVAX1-D1ME expressing the prME protein of DV1 was inoculated in BALB/c mice via intramuscular injection or electroporation, and the immunogenicity and protection were evaluated...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28500811/cost-effectiveness-of-dengue-vaccination-programs-in-brazil
#18
Eunha Shim
AbstractThe first approved dengue vaccine, CYD-TDV, a chimeric, live-attenuated, tetravalent dengue virus vaccine, was recently licensed in 13 countries, including Brazil. In light of recent vaccine approval, we modeled the cost-effectiveness of potential vaccination policies mathematically based on data from recent vaccine efficacy trials that indicated that vaccine efficacy was lower in seronegative individuals than in seropositive individuals. In our analysis, we investigated several vaccination programs, including routine vaccination, with various vaccine coverage levels and those with and without large catch-up campaigns...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28473308/sa%C3%A3%C2%BAde-na-copa-the-world-s-first-application-of-participatory-surveillance-for-a-mass-gathering-at-fifa-world-cup-2014-brazil
#19
Onicio Leal Neto, George Santiago Dimech, Marlo Libel, Wayner Vieira de Souza, Eduarda Cesse, Mark Smolinski, Wanderson Oliveira, Jones Albuquerque
BACKGROUND: The 2005 International Health Regulations (IHRs) established parameters for event assessments and notifications that may constitute public health emergencies of international concern. These requirements and parameters opened up space for the use of nonofficial mechanisms (such as websites, blogs, and social networks) and technological improvements of communication that can streamline the detection, monitoring, and response to health problems, and thus reduce damage caused by these problems...
May 4, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28468604/simultaneous-detection-of-chikungunya-virus-dengue-virus-and-human-pathogenic-leptospira-genomes-using-a-multiplex-taqman%C3%A2-assay
#20
Claude Giry, Bénédicte Roquebert, Ghislaine Li-Pat-Yuen, Philippe Gasque, Marie-Christine Jaffar-Bandjee
BACKGROUND: In 2005-2006 a major epidemics of Chikungunya disease occurred in South-West Indian Ocean islands. In Reunion Island, the magnitude of Chikungunya infection related symptoms was high and with over 38% of serological prevalence in the population. This epidemics illustrated the potential threat of emerging arboviral diseases for inhabitants of Reunion Island and elsewhere since vectors are worldwide distributed. A sentinel surveillance network was set-up to detect emerging pathogens associated with fever over 38 °C and in the absence of known etiologic causes...
May 3, 2017: BMC Microbiology
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