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https://www.readbyqxmd.com/read/27924792/a-cost-effective-approach-to-the-diagnosis-and-management-of-acute-infectious-encephalitis
#1
Usha Kant Misra, Vinita Elizabeth Mani, Jayantee Kalita
SETTING: A tertiary care teaching hospital in India. OBJECTIVE: To report a syndromic approach to acute encephalitis syndrome (AES) and propose a cost-effective model. STUDY DESIGN: AES patients were categorized by the presence or absence of myalgia/rash into systemic and neurological AES. The patients with systemic AES were investigated for dengue, scrub typhus, leptospira, chikungunya, and malaria, and those with neurological AES were investigated for herpes and Japanese encephalitis (JE)...
December 8, 2016: European Neurology
https://www.readbyqxmd.com/read/27908746/willingness-to-pay-for-a-dengue-vaccine-and-its-associated-determinants-in-indonesia-a-community-based-cross-sectional-survey-in-aceh
#2
Harapan Harapan, Samsul Anwar, Aslam Bustamam, Arsil Radiansyah, Pradiba Angraini, Riny Fasli, Salwiyadi Salwiyadi, Reza Akbar Bastian, Ade Oktiviyari, Imaduddin Akmal, Muhammad Iqbalamin, Jamalul Adil, Fenni Henrizal, Darmayanti Darmayanti, Mahmuda Mahmuda, Mudatsir Mudatsir, Allison Imrie, R Tedjo Sasmono, Ulrich Kuch, Ziv Shkedy, Setia Pramana
Vaccination strategies are being considered as a part of dengue prevention programs in endemic countries. To accelerate the introduction of dengue vaccine into the public sector program and private markets, understanding the private economic benefits of a dengue vaccine is therefore essential. The aim of this study was to assess the willingness to pay (WTP) for a dengue vaccine among community members in Indonesia and its associated explanatory variables. A community-based, cross-sectional survey was conducted in nine regencies of Aceh province, Indonesia, from November 2014 to March 2015...
November 28, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27905501/using-baidu-search-index-to-predict-dengue-outbreak-in-china
#3
Kangkang Liu, Tao Wang, Zhicong Yang, Xiaodong Huang, Gabriel J Milinovich, Yi Lu, Qinlong Jing, Yao Xia, Zhengyang Zhao, Yang Yang, Shilu Tong, Wenbiao Hu, Jiahai Lu
This study identified the possible threshold to predict dengue fever (DF) outbreaks using Baidu Search Index (BSI). Time-series classification and regression tree models based on BSI were used to develop a predictive model for DF outbreak in Guangzhou and Zhongshan, China. In the regression tree models, the mean autochthonous DF incidence rate increased approximately 30-fold in Guangzhou when the weekly BSI for DF at the lagged moving average of 1-3 weeks was more than 382. When the weekly BSI for DF at the lagged moving average of 1-5 weeks was more than 91...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27898668/the-long-term-safety-public-health-impact-and-cost-effectiveness-of-routine-vaccination-with-a-recombinant-live-attenuated-dengue-vaccine-dengvaxia-a-model-comparison-study
#4
Stefan Flasche, Mark Jit, Isabel Rodríguez-Barraquer, Laurent Coudeville, Mario Recker, Katia Koelle, George Milne, Thomas J Hladish, T Alex Perkins, Derek A T Cummings, Ilaria Dorigatti, Daniel J Laydon, Guido España, Joel Kelso, Ira Longini, Jose Lourenco, Carl A B Pearson, Robert C Reiner, Luis Mier-Y-Terán-Romero, Kirsten Vannice, Neil Ferguson
BACKGROUND: Large Phase III trials across Asia and Latin America have recently demonstrated the efficacy of a recombinant, live-attenuated dengue vaccine (Dengvaxia) over the first 25 mo following vaccination. Subsequent data collected in the longer-term follow-up phase, however, have raised concerns about a potential increase in hospitalization risk of subsequent dengue infections, in particular among young, dengue-naïve vaccinees. We here report predictions from eight independent modelling groups on the long-term safety, public health impact, and cost-effectiveness of routine vaccination with Dengvaxia in a range of transmission settings, as characterised by seroprevalence levels among 9-y-olds (SP9)...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27888023/integrated-process-for-the-purification-and-immobilization-of-the-envelope-protein-domain-iii-of-dengue-virus-type-2-expressed-in-rachiplusia-nu-larvae-and-its-potential-application-in-a-diagnostic-assay
#5
María Emilia Smith, Alexandra Marisa Targovnik, Julieta Cerezo, María Alejandra Morales, María Victoria Miranda, Julián Rodríguez Talou
Dengue incidence has grown dramatically in the last years, with about 40% of the world population at risk of infection. Recently, a vaccine developed by Sanofi Pasteur has been registered, but only in a few countries. Moreover, specific antiviral drugs are not available. Thus, an efficient and accurate diagnosis is important for disease management. To develop a low-cost immunoassay for dengue diagnosis, in the present study we expressed the envelope protein domain III of dengue virus type 2 in Rachiplusia nu larvae by infection with a recombinant baculovirus...
November 22, 2016: Protein Expression and Purification
https://www.readbyqxmd.com/read/27870689/zika-virus-and-diagnostics
#6
Claudia Raja Gabaglia
PURPOSE OF REVIEW: The purpose of this review is to present what is known about the Zika virus (ZIKV) at the time of writing this review. The viral structure and its phylogeny, as well as the limitations of current available techniques used for diagnosis, are discussed. RECENT FINDINGS: Crystallography and cryo-electron microscopy of the whole ZIKV, or a few of its proteins, are confirming its overall antigenic relatedness to other flaviviruses. Sequencing has revealed its dynamic genetic variation and has placed the Western cluster of Zika isolates within the Asian phylogenic tree...
November 18, 2016: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/27869956/-aedes-aegypti-control-strategies-a-review
#7
Ana Laura de Sene Amâncio Zara, Sandra Maria Dos Santos, Ellen Synthia Fernandes-Oliveira, Roberta Gomes Carvalho, Giovanini Evelim Coelho
OBJECTIVE: to describe the main strategies to control Aedes aegypti, with emphasis on promising technological innovations for use in Brazil. METHODS: this study is a non-systematic review of the literature. Results: several technologies have been developed as alternatives in the control of Ae. aegypti, using different mechanisms of action, such as selective monitoring of the infestation, social interventions, dispersing insecticides, new biological control agents and molecular techniques for population control of mosquitoes, also considering the combination between them...
April 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27860384/lateral-flow-assay-based-on-paper-hydrogel-hybrid-material-for-sensitive-point-of-care-detection-of-dengue-virus
#8
Jane Ru Choi, Kar Wey Yong, Ruihua Tang, Yan Gong, Ting Wen, Hui Yang, Ang Li, Yook Chin Chia, Belinda Pingguan-Murphy, Feng Xu
Paper-based devices have been broadly used for the point-of-care detection of dengue viral nucleic acids due to their simplicity, cost-effectiveness, and readily observable colorimetric readout. However, their moderate sensitivity and functionality have limited their applications. Despite the above-mentioned advantages, paper substrates are lacking in their ability to control fluid flow, in contrast to the flow control enabled by polymer substrates (e.g., agarose) with readily tunable pore size and porosity...
November 8, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27810313/the-economic-promise-of-developing-and-implementing-dengue-vaccines-evidence-from-a-systematic-review
#9
REVIEW
Iara C Endo, Patricia K Ziegelmann, Anita Patel
BACKGROUND: Dengue fever is one of the most rapidly advancing viral vector-borne diseases worldwide and vaccine candidates are in the final stages of clinical trials, representing a decisive opportunity to control the disease. To decide whether and where to support the introduction of new vaccines it is crucial to assess costs imposed by the disease and cost-effectiveness of vaccine programmes. OBJECTIVE: To identify economic evidence about dengue fever immunization, by systematic review, to assist future policy decisions and investment...
December 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27802282/correction-calculation-of-the-average-cost-per-case-of-dengue-fever-in-mexico-using-a-micro-costing-approach
#10
Adriana Zubieta-Zavala, Guillermo Salinas-Escudero, Adrian Ramírez-Chávez, Luis García-Valladares, Malaquias López-Cervantes, Juan Guillermo López Yescas, Luis Durán-Arenas
[This corrects the article DOI: 10.1371/journal.pntd.0004897.].
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27742355/pyrethroid-resistance-in-aedes-aegypti-and-aedes-albopictus-important-mosquito-vectors-of-human-diseases
#11
Letícia B Smith, Shinji Kasai, Jeffrey G Scott
Aedes aegypti and A. albopictus mosquitoes are vectors of important human disease viruses, including dengue, yellow fever, chikungunya and Zika. Pyrethroid insecticides are widely used to control adult Aedes mosquitoes, especially during disease outbreaks. Herein, we review the status of pyrethroid resistance in A. aegypti and A. albopictus, mechanisms of resistance, fitness costs associated with resistance alleles and provide suggestions for future research. The widespread use of pyrethroids has given rise to many populations with varying levels of resistance worldwide, albeit with substantial geographical variation...
October 2016: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/27622802/dengue-mortality-in-colombia-1985-2012
#12
Pablo Chaparro-Narváez, Willian León-Quevedo, Carlos Andrés Castañeda-Orjuela
INTRODUCTION: Dengue in Colombia is an important public health problem due to the huge economic and social costs it has caused, especially during the disease outbreaks.  OBJECTIVE: To describe the behavior of dengue mortality in Colombia between 1985 and 2012.  MATERIALS AND METHODS: We conducted a descriptive study. Information was obtained from mortality and population projection databases provided by the Departamento Administrativo Nacional de Estadística (DANE) for the 1985-2012 period...
2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27618859/costs-and-benefits-of-vertical-and-horizontal-transmission-of-dengue-virus
#13
Gloria Ruiz-Guzmán, José Ramos-Castañeda, Angélica Hernández-Quintero, Jorge Contreras-Garduño
Parasites can be transmitted vertically and/or horizontally, but the costs or benefits for the host of infection have only been tested after horizontal transmission. Here, we report for the first time, to our knowledge, the survival, reproduction and infection of Aedes aegypti during vertical and horizontal transmission of dengue virus 2 (DENV-2). Females infected horizontally produced more eggs, with a sex ratio skewed towards males, compared with uninfected controls. However, there was no significant difference in the number of emerging adults or in survival of mothers...
November 15, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27611658/single-step-biological-fabrication-of-colloidal-silver-nanoparticles-using-hugonia-mystax-larvicidal-potential-against-zika-virus-dengue-and-malaria-vector-mosquitoes
#14
Marimuthu Govindarajan, Shine Kadaikunnan, Naiyf S Alharbi, Giovanni Benelli
Mosquito control is facing key challenges, including outbreaks of new arbovirus threats. We proposed an eco-friendly synthesis of silver nanoparticles (AgNPs) employing a low-cost extract of Hugonia mystax. AgNPs were specified by UV, XRD, FTIR and EDX spectroscopy, SEM and TEM. AgNPs were more toxic to Anopheles stephensi, Aedes aegypti, and Culex quinquefasciatus larvae (LC50: 14.45, 15.86, and 17.46 μg/mL) if compared to aquatic biocontrol organisms Gambusia affinis, Diplonychus indicus, and Anisops bouvieri (LC50: 2567...
September 9, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27604128/acute-toxicity-and-repellent-activity-of-the-origanum-scabrum-boiss-heldr-lamiaceae-essential-oil-against-four-mosquito-vectors-of-public-health-importance-and-its-biosafety-on-non-target-aquatic-organisms
#15
Marimuthu Govindarajan, Shine Kadaikunnan, Naiyf S Alharbi, Giovanni Benelli
The recent outbreaks of dengue, chikungunya, and Zika virus highlighted the pivotal importance of mosquito vector control in tropical and subtropical areas worldwide. However, mosquito control is facing hot challenges, mainly due to the rapid development of pesticide resistance in Culicidae and the limited success of biocontrol programs on Aedes mosquitoes. In this framework, screening botanicals for their mosquitocidal potential may offer effective and eco-friendly tools in the fight against mosquitoes. In the present study, the essential oil (EO) obtained from the medicinal plant Origanum scabrum was analyzed by GC-MS and evaluated for its mosquitocidal and repellent activities towards Anopheles stephensi, Aedes aegypti, Culex quinquefasciatus, and Culex tritaeniorhynchus...
September 8, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27601519/dengue-dynamics-and-vaccine-cost-effectiveness-analysis-in-the-philippines
#16
Eunha Shim
Dengue is one of the most problematic vector-borne diseases in the Philippines, with an estimated 842,867 cases resulting in medical costs of $345 million U.S. dollars annually. In December 2015, the first dengue vaccine, known as chimeric yellow fever virus-dengue virus tetravalent dengue vaccine, was approved for use in the Philippines and is given to children 9 years of age. To estimate the cost-effectiveness of dengue vaccination in the Philippines, we developed an age-structured model of dengue transmission and vaccination...
September 6, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27501146/calculation-of-the-average-cost-per-case-of-dengue-fever-in-mexico-using-a-micro-costing-approach
#17
Adriana Zubieta-Zavala, Guillermo Salinas-Escudero, Adrian Ramírez-Chávez, Luis García-Valladares, Malaquias López-Cervantes, Juan Guillermo López Yescas, Luis Durán-Arenas
INTRODUCTION: The increasing burden of dengue fever (DF) in the Americas, and the current epidemic in previously unaffected countries, generate major costs for national healthcare systems. There is a need to quantify the average cost per DF case. In Mexico, few data are available on costs, despite DF being endemic in some areas. Extrapolations from studies in other countries may prove unreliable and are complicated by the two main Mexican healthcare systems (the Secretariat of Health [SS] and the Mexican Social Security Institute [IMSS])...
August 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27461457/assessing-dengue-vaccination-impact-model-challenges-and-future-directions
#18
Mario Recker, Kirsten Vannice, Joachim Hombach, Mark Jit, Cameron P Simmons
In response to the sharp rise in the global burden caused by dengue virus (DENV) over the last few decades, the WHO has set out three specific key objectives in its disease control strategy: (i) to estimate the true burden of dengue by 2015; (ii) a reduction in dengue mortality by at least 50% by 2020 (used as a baseline); and (iii) a reduction in dengue morbidity by at least 25% by 2020. Although various elements will all play crucial parts in achieving this goal, from diagnosis and case management to integrated surveillance and outbreak response, sustainable vector control, vaccine implementation and finally operational and implementation research, it seems clear that new tools (e...
August 31, 2016: Vaccine
https://www.readbyqxmd.com/read/27413521/clinical-and-laboratory-characteristics-of-dengue-orientia-tsutsugamushi-co-infection-from-a-tertiary-care-center-in-south-india
#19
Aneesh Basheer, Nayyar Iqbal, Sudhagar Mookkappan, Patricia Anitha, Shashikala Nair, Reba Kanungo, Ravichandran Kandasamy
BACKGROUND: Concurrent infection with multiple pathogens is common in tropics, posing diagnostic and treatment challenges. Although co-infections of dengue, malaria, leptospirosis and typhoid in various combinations have been described, data on dengue and scrub typhus co-infection is distinctly limited. METHODOLOGY: This study was a retrospective analysis of dengue and scrub typhus co-infection diagnosed between January 2010 and July 2014 at a tertiary care center...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27350908/detection-of-dengue-west-nile-virus-rickettsiosis-and-leptospirosis-by-a-new-real-time-pcr-strategy
#20
Daniel García-Ruíz, Marco A Martínez-Guzmán, Albertina Cárdenas-Vargas, Erika Marino-Marmolejo, Abel Gutiérrez-Ortega, Esteban González-Díaz, Rayo Morfin-Otero, Eduardo Rodríguez-Noriega, Hector Pérez-Gómez, Darwin Elizondo-Quiroga
Dengue virus (DENV) infection causes sudden fever along with several nonspecific signs and symptoms and in severe cases, death. DENV is transmitted to people by Aedes aegypti and Ae. albopictus mosquitoes, whose populations increase during rainy season. West Nile Virus (WNV), Rickettsia spp. and Leptospira spp. are fever-causing pathogens that share many of the initial symptoms of DENV infection and also thrive in the rainy season. Outbreaks in some regions may be due to any of these pathogens that can co-circulate...
2016: SpringerPlus
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