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https://www.readbyqxmd.com/read/29777650/modeling-dengue-vector-population-using-remotely-sensed-data-and-machine-learning
#1
Juan M Scavuzzo, Francisco Trucco, Manuel Espinosa, Carolina B Tauro, Marcelo Abril, Carlos M Scavuzzo, Alejandro C Frery
Mosquitoes are vectors of many human diseases. In particular, Aedes ægypti (Linnaeus) is the main vector for Chikungunya, Dengue, and Zika viruses in Latin America and it represents a global threat. Public health policies that aim at combating this vector require dependable and timely information, which is usually expensive to obtain with field campaigns. For this reason, several efforts have been done to use remote sensing due to its reduced cost. The present work includes the temporal modeling of the oviposition activity (measured weekly on 50 ovitraps in a north Argentinean city) of Aedes ægypti (Linnaeus), based on time series of data extracted from operational earth observation satellite images...
May 16, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29758050/an-assessment-of-false-positive-rates-for-malaria-rapid-diagnostic-tests-caused-by-non-plasmodium-infectious-agents-and-immunological-factors
#2
Michelle L Gatton, Sadmir Ciketic, John W Barnwell, Qin Cheng, Peter L Chiodini, Sandra Incardona, David Bell, Jane Cunningham, Iveth J González
BACKGROUND: Malaria rapid diagnostic tests (RDTs) can produce false positive (FP) results in patients with human African trypanosomiasis and rheumatoid factor (RF), but specificity against other infectious agents and immunological factors is largely unknown. Low diagnostic specificity caused by cross-reactivity may lead to over-estimates of the number of malaria cases and over-use of antimalarial drugs, at the cost of not diagnosing and treating the true underlying condition. METHODS: Data from the WHO Malaria RDT Product Testing Programme was analysed to assess FP rates of 221 RDTs against four infectious agents (Chagas, dengue, Leishmaniasis and Schistosomiasis) and four immunological factors (anti-nuclear antibody, human anti-mouse antibody (HAMA), RF and rapid plasma regain)...
2018: PloS One
https://www.readbyqxmd.com/read/29757507/mosquito-traps-for-urban-surveillance-collection-efficacy-and-potential-for-use-by-citizen-scientists
#3
Mathieu Bazin, Craig R Williams
Mosquito-borne diseases are a pervasive public health problem on a global scale, and effective management of them requires well-designed surveillance programs for both vectors and pathogens. Mosquito traps are a common component of such programs, and their reach can be expanded by engaging citizen scientists. In this study in a southern Australian city, we compared the mosquito collection efficacy of two types of traps and assessed their suitability for use in citizen science programs. BG Sentinels and BG Gravid Aedes Trap (BG-GAT) traps both collected Aedes and Culex species in similar proportions, albeit with the former collecting approximately nine times as many mosquitoes...
June 2018: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/29755433/-de-novo-dna-synthesis-in-aedes-aegypti-midgut-cells-as-a-complementary-strategy-to-limit-dengue-viral-replication
#4
Javier Serrato-Salas, Salvador Hernández-Martínez, Jesús Martínez-Barnetche, Renaud Condé, Alejandro Alvarado-Delgado, Federico Zumaya-Estrada, Humberto Lanz-Mendoza
Aedes aegypti is the main vector of Dengue Virus, carrying the virus during the whole mosquito life post-infection. Few mosquito fitness costs have been associated to the virus infection, thereby allowing for a swift dissemination. In order to diminish the mosquito population, public health agency use persistent chemicals with environmental impact for disease control. Most countries barely use biological controls, if at all. With the purpose of developing novel Dengue control strategies, a detailed understanding of the unexplored virus-vector interactions is urgently needed...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29727447/early-warning-and-response-system-ewars-for-dengue-outbreaks-recent-advancements-towards-widespread-applications-in-critical-settings
#5
Laith Hussain-Alkhateeb, Axel Kroeger, Piero Olliaro, Joacim Rocklöv, Maquins Odhiambo Sewe, Gustavo Tejeda, David Benitez, Balvinder Gill, S Lokman Hakim, Roberta Gomes Carvalho, Leigh Bowman, Max Petzold
BACKGROUND: Dengue outbreaks are increasing in frequency over space and time, affecting people's health and burdening resource-constrained health systems. The ability to detect early emerging outbreaks is key to mounting an effective response. The early warning and response system (EWARS) is a toolkit that provides countries with early-warning systems for efficient and cost-effective local responses. EWARS uses outbreak and alarm indicators to derive prediction models that can be used prospectively to predict a forthcoming dengue outbreak at district level...
2018: PloS One
https://www.readbyqxmd.com/read/29694033/quantum-dot-pna-conjugates-for-target-catalyzed-rna-detection
#6
Oleksandr Zavoiura, Ute Resch-Genger, Oliver Seitz
Detection of pathogenic nucleic acids remains one of the most reliable approaches for the diagnosis of a broad range of diseases. Current PCR-based methods require experienced personnel and cannot be easily used for point-of-care diagnostics, making alternative strategies for the sensitive, reliable, and cost-efficient detection of pathogenic nucleic acids highly desirable. Here, we report an enzyme-free method for the fluorometric detection of RNA that relies on a target-induced fluorophore transfer onto a semiconductor quantum dot (QD), uses PNA probes as selective recognition elements and can be readout with simple and inexpensive equipment...
April 25, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29692583/effect-of-introduction-of-single-donor-apheresis-platelets-in-dengue-management-a-comparative-analysis-of-two-consecutive-dengue-epidemics
#7
Sonam Kansay, Harinder Singh
BACKGROUND: The frequency of dengue outbreak is increasing in Southeast Asian countries these days and since there are no specific drugs against the dengue virus; therefore, treatment consists of mainly symptomatic and supportive care. AIMS: Platelet transfusion forms one of the major parts of treatment therapy in dengue; therefore, this study was initiated to elicit the effect of introduction of single-donor apheresis platelets (SDAPs) in dengue management. SETTINGS AND DESIGN: This is a retrospective study conducted on 622 clinically suspected cases of dengue infection who received platelet transfusions between August 2013 and December 2015 in a teaching hospital of North India...
April 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29690895/history-epidemiology-and-diagnostics-of-dengue-in-the-american-and-brazilian-contexts-a-review
#8
REVIEW
Tiago Souza Salles, Thayane da Encarnação Sá-Guimarães, Evelyn Seam Lima de Alvarenga, Victor Guimarães-Ribeiro, Marcelo Damião Ferreira de Meneses, Patricia Faria de Castro-Salles, Carlucio Rocha Dos Santos, Ana Claudia do Amaral Melo, Marcia Regina Soares, Davis Fernandes Ferreira, Monica Ferreira Moreira
Dengue virus (DENV), an arbovirus transmitted by mosquitoes, has become a major threat to American human life, reaching approximately 23 million cases from 1980 to 2017. Brazil is among the countries most affected by this terrible viral disease, with 13.6 million cases. DENV has four different serotypes, DENV1-4, which show a broad clinical spectrum. Dengue creates a staggering epidemiological and economic burden for endemic countries. Without a specific therapy and with a commercial vaccine that presents some problems relative to its full effectiveness, initiatives to improve vector control strategies, early disease diagnostics and the development of vaccines and antiviral drugs are priorities...
April 24, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29688342/why-funding-for-neglected-tropical-diseases-should-be-a-global-priority
#9
Sharon L Reed, James H McKerrow
Neglected Tropical Diseases affect more than 1 billion of the world's poorest people. Control programs range from near elimination (dracunculiasis) to increasing prevalence (dengue and cutaneous leishmaniasis). These are some of the most cost-effective public health interventions in the world and should be a global priority.
April 24, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29659574/the-impact-of-school-water-sanitation-and-hygiene-improvements-on-infectious-disease-using-serum-antibody-detection
#10
Anna N Chard, Victoria Trinies, Delynn M Moss, Howard H Chang, Seydou Doumbia, Patrick J Lammie, Matthew C Freeman
BACKGROUND: Evidence from recent studies assessing the impact of school water, sanitation and hygiene (WASH) interventions on child health has been mixed. Self-reports of disease are subject to bias, and few WASH impact evaluations employ objective health measures to assess reductions in disease and exposure to pathogens. We utilized antibody responses from dried blood spots (DBS) to measure the impact of a school WASH intervention on infectious disease among pupils in Mali. METHODOLOGY/PRINCIPAL FINDINGS: We randomly selected 21 beneficiary primary schools and their 21 matched comparison schools participating in a matched-control trial of a comprehensive school-based WASH intervention in Mali...
April 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29642937/evaluation-of-a-simple-polytetrafluoroethylene-ptfe-based-membrane-for-blood-feeding-of-malaria-and-dengue-fever-vectors-in-the-laboratory
#11
Doreen J Siria, Elis P A Batista, Mercy A Opiyo, Elizangela F Melo, Robert D Sumaye, Halfan S Ngowo, Alvaro E Eiras, Fredros O Okumu
BACKGROUND: Controlled blood-feeding is essential for maintaining laboratory colonies of disease-transmitting mosquitoes and investigating pathogen transmission. We evaluated a low-cost artificial feeding (AF) method, as an alternative to direct human feeding (DHF), commonly used in mosquito laboratories. METHODS: We applied thinly-stretched pieces of polytetrafluoroethylene (PTFE) membranes cut from locally available seal tape (i.e. plumbers tape, commonly used for sealing pipe threads in gasworks or waterworks)...
April 11, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29573874/a-multi-country-study-of-dengue-vaccination-strategies-with-dengvaxia-and-a-future-vaccine-candidate-in-three-dengue-endemic-countries-vietnam-thailand-and-colombia
#12
Jung-Seok Lee, José Lourenço, Sunetra Gupta, Andrew Farlow
BACKGROUND: The dengue vaccination era began when Dengvaxia (CYD-TDV) became available in 2016. In addition, several second-generation vaccine candidates are currently in phase 3 trials, suggesting that a broader availability of dengue vaccines may be possible in the near future. Advancing on the recent WHO-SAGE recommendations for the safe and effective use of CYD-TDV at the regional level on average, this study investigates the vaccination impacts and cost-effectiveness of CYD-TDV and of a hypothetical new vaccine candidate (NVC) in a country-specific manner for three endemic countries: Vietnam, Thailand, and Colombia...
March 21, 2018: Vaccine
https://www.readbyqxmd.com/read/29564154/severity-and-burden-of-hand-foot-and-mouth-disease-in-asia-a-modelling-study
#13
Wee Ming Koh, Hishamuddin Badaruddin, Hanh La, Mark I-Cheng Chen, Alex R Cook
Background: Hand, foot and mouth disease (HFMD) affects millions of children across Asia annually, leading to an increase in implemented control policies such as surveillance, isolation and social distancing in affected jurisdictions. However, limited knowledge of disease burden and severity causes difficulty in policy optimisation as the associated economic cost cannot be easily estimated. We use a data synthesis approach to provide a comprehensive picture of HFMD disease burden, estimating infection risk, symptomatic rates, the risk of complications and death, and overall disability-adjusted life-year (DALY) losses, along with associated uncertainties...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29560461/development-of-single-step-rt-pcr-for-detection-of-kyasanur-forest-disease-virus-from-clinical-samples
#14
Gouri Chaubal, Prasad Sarkale, Pravin Kore, Pragya Yadav
Background: Kyasanur Forest Disease (KFD), a tick borne flavivirus, which was earlier endemic to Karnataka state, India, has been confirmed and detected from neighboring states of Tamil Nadu, Maharashtra, Goa and Kerala states in India. Increased human and vector surveillance therefore becomes essential for the identification of KFD affected regions and control of further spread of the disease. Currently, available KFD detection assays include realtime RT-PCR and nested RT-PCR assays...
February 2018: Heliyon
https://www.readbyqxmd.com/read/29554095/the-mixture-of-cashew-nut-shell-liquid-and-castor-oil-results-in-an-efficient-larvicide-against-aedes-aegypti-that-does-not-alter-embryo-fetal-development-reproductive-performance-or-dna-integrity
#15
Juliana Miron Vani, Maria Tereza Ferreira Duenhas Monreal, Sarah Alves Auharek, Andréa Luiza Cunha-Laura, Eduardo José de Arruda, Alessandra Ramos Lima, Cicera Maria da Silva, Andréia Conceição Milan Brochado Antoniolli-Silva, Dênis Pires de Lima, Adilson Beatriz, Rodrigo Juliano Oliveira
Dengue fever, chikungunya fever and Zika virus are epidemics in Brazil that are transmitted by mosquitoes, such as Aedes aegypti or Aedes albopictus. The liquid from shells of cashew nuts is attractive for its important biological and therapeutic activities, which include toxicity to mosquitoes of the genus Aedes. The present study evaluated the effects of a mixture of surfactants from natural cashew nutshell liquid and castor oil (named TaLCC-20) on the mortality of larvae and on the reproductive performance, embryonic and fetal development and genetic stability of Swiss mice...
2018: PloS One
https://www.readbyqxmd.com/read/29513820/improved-reverse-transcription-polymerase-chain-reaction-assay-for-the-detection-of-flaviviruses-with-semi-nested-primers-for-discrimination-between-dengue-virus-serotypes-and-zika-virus
#16
Allan Rd Nunes, Brenda Elen B Alves, Hannaly Wb Pereira, Yasmin M Nascimento, Ingryd C Morais, José Veríssimo Fernandes, Josélio Mg Araújo, Daniel Cf Lanza
BACKGROUND The genus Flavivirus includes a variety of medically important viruses, including dengue virus (DENV) and Zika virus (ZIKV), which are most prevalent in Brazil. Because the clinical profile of patients affected by different DENV serotypes or ZIKV may be similar, the development of new methods that facilitate a rapid and accurate diagnosis is crucial. OBJECTIVES The current study aimed to develop an improved reverse transcription-polymerase chain reaction (RT-PCR) protocol for universal detection of flaviviruses by using semi-nested primers that discriminate between DENV serotypes and ZIKV...
2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29463300/effectiveness-of-a-field-trap-barrier-system-for-controlling-aedes-albopictus-a-removal-trapping-strategy
#17
Mohammad Akhoundi, Frédéric Jourdain, Fabrice Chandre, Pascal Delaunay, David Roiz
BACKGROUND: Aedes aegypti and Aedes albopictus are the main vectors for the transmission of several viral pathogens, in particular, dengue, Zika and chikungunya. In the absence of vaccines and treatment, control of Aedes mosquitoes is the only means of keeping these diseases in check. Aedes control is difficult, and it is, therefore, necessary to evaluate the efficacy of novel control methods, particularly those targeting adult and exophilic Ae. albopictus populations. METHODS: We carried out the first evaluation of the effectiveness of a field trap barrier system, i...
February 20, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29462598/using-adult-aedes-aegypti-females-to-predict-areas-at-risk-for-dengue-transmission-a-spatial-case-control-study
#18
Maisa Carla Pereira Parra, Eliane Aparecida Fávaro, Margareth Regina Dibo, Adriano Mondini, Álvaro Eduardo Eiras, Erna Geessien Kroon, Mauro Martins Teixeira, Mauricio Lacerda Nogueira, Francisco Chiaravalloti-Neto
INTRODUCTION: Traditional indices for measuring dengue fever risk in a given area are based on the immature forms of the vector (larvae and pupae surveys). However, this is inefficient because only adult female mosquitoes actually transmit the virus. Based on these assumptions, our objective was to evaluate the association between an entomological index obtained from adult mosquito traps and the occurrence of dengue in a hyperendemic area. Additionally, we compared its cost to that of the Breteau Index (BI)...
June 2018: Acta Tropica
https://www.readbyqxmd.com/read/29460859/improving-vector-borne-pathogen-surveillance-a-laboratory-based-study-exploring-the-potential-to-detect-dengue-virus-and-malaria-parasites-in-mosquito-saliva
#19
Vanessa R Melanson, Ryan Jochim, Michael Yarnell, Karen Bingham Ferlez, Soumya Shashikumar, Jason H Richardson
Background & objectives: Vector-borne pathogen surveillance programmes typically rely on the collection of large numbers of potential vectors followed by screening protocols focused on detecting pathogens in the arthropods. These processes are laborious, time consuming, expensive, and require screening of large numbers of samples. To streamline the surveillance process, increase sample throughput, and improve cost-effectiveness, a method to detect dengue virus and malaria parasites (Plasmodium falciparum) by leveraging the sugar-feeding behaviour of mosquitoes and their habit of expectorating infectious agents in their saliva during feeding was investigated in this study...
October 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29458406/assessing-dengue-transmission-risk-and-a-vector-control-intervention-using-entomological-and-immunological-indices-in-thailand-study-protocol-for-a-cluster-randomized-controlled-trial
#20
Hans J Overgaard, Chamsai Pientong, Kesorn Thaewnongiew, Michael J Bangs, Tipaya Ekalaksananan, Sirinart Aromseree, Thipruethai Phanitchat, Supranee Phanthanawiboon, Benedicte Fustec, Vincent Corbel, Dominique Cerqueira, Neal Alexander
BACKGROUND: Dengue fever is the most common and widespread mosquito-borne arboviral disease in the world. There is a compelling need for cost-effective approaches and practical tools that can reliably measure real-time dengue transmission dynamics that enable more accurate and useful predictions of incidence and outbreaks. Sensitive surveillance tools do not exist today, and only a small handful of new control strategies are available. Vector control remains at the forefront for combating dengue transmission...
February 20, 2018: Trials
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