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https://www.readbyqxmd.com/read/29331246/estimation-of-expected-dengue-seroprevalence-from-passive-epidemiological-surveillance-systems-in-selected-areas-of-argentina-a-proxy-to-evaluate-the-applicability-of-dengue-vaccination
#1
Pablo Orellano, Darío Vezzani, Nancy Quaranta, Julieta Reynoso, Oscar Daniel Salomón
BACKGROUND: Current recommendations about dengue vaccination by the World Health Organization depend on seroprevalence levels and serological status in populations and individuals. However, seroprevalence estimation may be difficult due to a diversity of factors. Thus, estimation through models using data from epidemiological surveillance systems could be an alternative procedure to achieve this goal. OBJECTIVE: To estimate the expected dengue seroprevalence in children of selected areas in Argentina, using a simple model based on data from passive epidemiological surveillance systems...
January 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29295568/development-of-antibody-therapeutics-against-flaviviruses
#2
REVIEW
Haiyan Sun, Qiang Chen, Huafang Lai
Recent outbreaks of Zika virus (ZIKV) highlight the urgent need to develop efficacious interventions against flaviviruses, many of which cause devastating epidemics around the world. Monoclonal antibodies (mAb) have been at the forefront of treatment for cancer and a wide array of other diseases due to their specificity and potency. While mammalian cell-produced mAbs have shown promise as therapeutic candidates against several flaviviruses, their eventual approval for human application still faces several challenges including their potential risk of predisposing treated patients to more severe secondary infection by a heterologous flavivirus through antibody-dependent enhancement (ADE)...
December 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29284474/a-systematic-review-of-the-economic-impact-of-rapid-diagnostic-tests-for-dengue
#3
Jacqueline Kyungah Lim, Neal Alexander, Gian Luca Di Tanna
BACKGROUND: Dengue fever is rapidly expanding geographically, with about half of the world's population now at risk. Among the various diagnostic options, rapid diagnostic tests (RDTs) are convenient and prompt, but limited in terms of accuracy and availability. METHODS: A systematic review was conducted of published data on the use of RDTs for dengue with respect to their economic impact. The search was conducted with combinations of key search terms, including "((Dengue[Title]) AND cost/economic)" and "rapid diagnostic test/assay (or point-of-care)"...
December 29, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29229427/cost-effectiveness-of-dengue-vaccination-in-ten-endemic-countries
#4
Wu Zeng, Yara A Halasa-Rappel, Nicolas Baurin, Laurent Coudeville, Donald S Shepard
Following publication of results from two phase-3 clinical trials in 10 countries or territories, endemic countries began licensing the first dengue vaccine in 2015. Using a published mathematical model, we evaluated the cost-effectiveness of dengue vaccination in populations similar to those at the trial sites in those same Latin American and Asian countries. Our main scenarios (30-year horizon, 80% coverage) entailed 3-dose routine vaccinations costing US$20/dose beginning at age 9, potentially supplemented by catch-up programs of 4- or 8-year cohorts...
December 8, 2017: Vaccine
https://www.readbyqxmd.com/read/29216317/novel-wolbachia-transinfected-aedes-aegypti-mosquitoes-possess-diverse-fitness-and-vector-competence-phenotypes
#5
Johanna E Fraser, Jyotika Taneja De Bruyne, Iñaki Iturbe-Ormaetxe, Justin Stepnell, Rhiannon L Burns, Heather A Flores, Scott L O'Neill
Wolbachia pipientis from Drosophila melanogaster (wMel) is an endosymbiotic bacterium that restricts transmission of human pathogenic flaviviruses and alphaviruses, including dengue, Zika, and chikungunya viruses, when introduced into the mosquito vector Aedes aegypti. To date, wMel-infected Ae. aegypti have been released in field trials in 5 countries to evaluate the effectiveness of this strategy for disease control. Despite the success in establishing wMel-infected mosquitoes in wild populations, and the well-characterized antiviral capabilities of wMel, transinfecting different or additional Wolbachia strains into Ae...
December 7, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29175781/in-silico-identification-and-evaluation-of-plant-flavonoids-as-dengue-ns2b-ns3-protease-inhibitors-using-molecular-docking-and-simulation-approach
#6
Muhammad Tahirul Qamar, Usman Ali Ashfaq, Kishver Tusleem, Arooj Mumtaz, Quratulain Tariq, Alina Goheer, Bilal Ahmed
Dengue infection is prevailing among the people not only from the developing countries but also from the developed countries due to its high morbidity rate around the globe. Hence, due to the unavailability of any suitable vaccine for rigorous dengue virus (DENV), the only mode of its treatment is prevention. The circumstances require an urgent development of efficient and practical treatment to deal with these serotypes. The severe effects and cost of synthetic vaccines simulated researchers to find anti-viral agents from medicinal plants...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29162320/controlled-human-infections-a-report-from-the-controlled-human-infection-models-workshop-leiden-university-medical-centre-4-6-may-2016
#7
Meta Roestenberg, Annie Mo, Peter G Kremsner, Maria Yazdanbakhsh
The principle of deliberately infecting humans with infectious agents in a controlled setting, so-called controlled human infections (CHI), is not novel. Many CHI models have a long history and were established decades ago such as the intentional exposure to yellow fever and dengue performed in the 1900's (Reed, 1902) [2]. In these times bioethics and scientific reasoning were in their infancy. Nowadays, clinical trials are highly regulated and CHI are executed worldwide. Controlled human malaria infections and influenza infections are the two most frequently practiced...
November 18, 2017: Vaccine
https://www.readbyqxmd.com/read/29154792/robust-real-time-cell-analysis-method-for-determining-viral-infectious-titers-during-development-of-a-viral-vaccine-production-process
#8
Cédric Charretier, Aure Saulnier, Loïc Benair, Corinne Armanet, Isabelle Bassard, Sandra Daulon, Bertrand Bernigaud, Emanuel Rodrigues de Sousa, Clémence Gonthier, Edouard Zorn, Emmanuelle Vetter, Claire Saintpierre, Patrice Riou, David Gaillac
The classical cell-culture methods, such as cell culture infectious dose 50% (CCID50) assays, are time-consuming, end-point assays currently used during the development of a viral vaccine production process to measure viral infectious titers. However, they are not suitable for handling the large number of tests required for high-throughput and large-scale screening analyses. Impedance-based bio-sensing techniques used in real-time cell analysis (RTCA) to assess cell layer biological status in vitro, provide real-time data...
November 14, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/29141713/resource-use-and-costs-of-dengue-analysis-of-data-from-phase-iii-efficacy-studies-of-a-tetravalent-dengue-vaccine
#9
Hanna El Fezzazi, Marie Branchu, Gabriel Carrasquilla, Punnee Pitisuttithum, Ana Paula Perroud, Carina Frago, Laurent Coudeville
A tetravalent dengue vaccine (CYD-TDV) has recently been approved in 12 countries in southeast Asia and Latin America for individuals aged 9-45 years or 9-60 years (age indication approvals vary by country) living in endemic areas. Data on utilization of medical and nonmedical resources as well as time lost from school and work were collected during the active phase of two phase III efficacy studies performed in 10 countries in the Asia-Pacific region and Latin America (NCT01373281; NCT01374516). We compared dengue-related resource utilization and costs among vaccinated and nonvaccinated participants...
October 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29110932/dengue-vaccine-supplies-under-endemic-and-epidemic-conditions-in-three-dengue-endemic-countries-colombia-thailand-and-vietnam
#10
Jung-Seok Lee, Jacqueline K Lim, Duc Anh Dang, Thi Hien Anh Nguyen, Andrew Farlow
BACKGROUND: Dengue fever has been a major public health concern in Colombia, Thailand, and Vietnam. Unlike other infectious diseases, dengue vaccines had not been available for a long time, causing difficulties to control the disease. However, the first live attenuated, tetravalent dengue vaccine (CYD-TDV) became available in 2016 and has been already licensed in some dengue-endemic countries. Because several second-generation dengue vaccines are also in the pipeline, it is critical to understand the efficient allocation of dengue vaccines considering the geographical variation of the disease...
October 27, 2017: Vaccine
https://www.readbyqxmd.com/read/29091713/after-the-epidemic-zika-virus-projections-for-latin-america-and-the-caribbean
#11
Felipe J Colón-González, Carlos A Peres, Christine Steiner São Bernardo, Paul R Hunter, Iain R Lake
BACKGROUND: Zika is one of the most challenging emergent vector-borne diseases, yet its future public health impact remains unclear. Zika was of little public health concern until recent reports of its association with congenital syndromes. By 3 August 2017 ∼217,000 Zika cases and ∼3,400 cases of associated congenital syndrome were reported in Latin America and the Caribbean. Some modelling exercises suggest that Zika virus infection could become endemic in agreement with recent declarations from the The World Health Organisation...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29084220/a-multi-country-study-of-the-economic-burden-of-dengue-fever-vietnam-thailand-and-colombia
#12
Jung-Seok Lee, Vittal Mogasale, Jacqueline K Lim, Mabel Carabali, Kang-Sung Lee, Chukiat Sirivichayakul, Duc Anh Dang, Diana Cristina Palencia-Florez, Thi Hien Anh Nguyen, Arthorn Riewpaiboon, Pornthep Chanthavanich, Luis Villar, Brian A Maskery, Andrew Farlow
BACKGROUND: Dengue fever is a major public health concern in many parts of the tropics and subtropics. The first dengue vaccine has already been licensed in six countries. Given the growing interests in the effective use of the vaccine, it is critical to understand the economic burden of dengue fever to guide decision-makers in setting health policy priorities. METHODS/PRINCIPAL FINDINGS: A standardized cost-of-illness study was conducted in three dengue endemic countries: Vietnam, Thailand, and Colombia...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29076644/image-enhancement-variational-methods-for-enabling-strong-cost-reduction-in-oled-based-point-of-care-immunofluorescent-diagnostic-systems
#13
Damiana Lazzaro, Serena Morigi, Patrizia Melpignano, Elena Piccolomini, Luca Benini
OBJECTIVE: Immunofluorescence diagnostic systems cost is often dominated by high-sensitivity, low-noise CCD-based cameras which are used to acquire the fluorescence images. In this paper we investigate the use of low-cost CMOS sensors in a point-of-care immunofluorescence diagnostic application for the detection and discrimination of four different serotypes of the Dengue virus in a set of human samples. METHODS: A two-phase post-processing software pipeline is proposed which consists in a first image enhancement stage for resolution increasing and segmentation, and a second diagnosis stage for the computation of the output concentrations...
October 27, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29066710/citizen-science-provides-a-reliable-and-scalable-tool-to-track-disease-carrying-mosquitoes
#14
John R B Palmer, Aitana Oltra, Francisco Collantes, Juan Antonio Delgado, Javier Lucientes, Sarah Delacour, Mikel Bengoa, Roger Eritja, Frederic Bartumeus
Recent outbreaks of Zika, chikungunya and dengue highlight the importance of better understanding the spread of disease-carrying mosquitoes across multiple spatio-temporal scales. Traditional surveillance tools are limited by jurisdictional boundaries and cost constraints. Here we show how a scalable citizen science system can solve this problem by combining citizen scientists' observations with expert validation and correcting for sampling effort. Our system provides accurate early warning information about the Asian tiger mosquito (Aedes albopictus) invasion in Spain, well beyond that available from traditional methods, and vital for public health services...
October 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29031082/quantum-associative-memory-with-linear-and-non-linear-algorithms-for-the-diagnosis-of-some-tropical-diseases
#15
J-P Tchapet Njafa, S G Nana Engo
This paper presents the QAMDiagnos, a model of Quantum Associative Memory (QAM) that can be a helpful tool for medical staff without experience or laboratory facilities, for the diagnosis of four tropical diseases (malaria, typhoid fever, yellow fever and dengue) which have several similar signs and symptoms. The memory can distinguish a single infection from a polyinfection. Our model is a combination of the improved versions of the original linear quantum retrieving algorithm proposed by Ventura and the non-linear quantum search algorithm of Abrams and Lloyd...
September 21, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29018222/spatial-temporal-distribution-of-dengue-and-climate-characteristics-for-two-clusters-in-sri-lanka-from-2012-to-2016
#16
Wei Sun, Ling Xue, Xiaoxue Xie
Dengue is a vector-borne disease causing high morbidity and mortality in tropical and subtropical countries. Urbanization, globalization, and lack of effective mosquito control have lead to dramatically increased frequency and magnitude of dengue epidemic in the past 40 years. The virus and the mosquito vectors keep expanding geographically in the tropical regions of the world. Using the hot spot analysis and the spatial-temporal clustering method, we investigated the spatial-temporal distribution of dengue in Sri Lanka from 2012 to 2016 to identify spatial-temporal clusters and elucidate the association of climatic factors with dengue incidence...
October 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28964768/clinical-laboratory-and-demographic-determinants-of-hospitalization-due-to-dengue-in-7613-patients-a-retrospective-study-based-on-hierarchical-models
#17
Natal Santos da Silva, Eduardo A Undurraga, Elis Regina da Silva Ferreira, Cássia Fernanda Estofolete, Maurício Lacerda Nogueira
In Brazil, the incidence of hospitalization due to dengue, as an indicator of severity, has drastically increased since 1998. The objective of our study was to identify risk factors associated with subsequent hospitalization related to dengue. We analyzed 7613 dengue confirmed via serology (ELISA), non-structural protein 1, or polymerase chain reaction amplification. We used a hierarchical framework to generate a multivariate logistic regression based on a variety of risk variables. This was followed by multiple statistical analyses to assess hierarchical model accuracy, variance, goodness of fit, and whether or not this model reliably represented the population...
September 28, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28956768/differentiated-human-sh-sy5y-cells-provide-a-reductionist-model-of-herpes-simplex-virus-1-neurotropism
#18
Mackenzie M Shipley, Colleen A Mangold, Chad V Kuny, Moriah L Szpara
Neuron-virus interactions that occur during herpes simplex virus (HSV) infection are not fully understood. Neurons are the site of lifelong latency and are a crucial target for long-term suppressive therapy or viral clearance. A reproducible neuronal model of human origin would facilitate studies of HSV and other neurotropic viruses. Current neuronal models in the herpesvirus field vary widely and have caveats, including incomplete differentiation, nonhuman origins, or the use of dividing cells that have neuropotential but lack neuronal morphology...
December 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28954927/rapid-antigen-tests-for-dengue-virus-serotypes-and-zika-virus-in-patient-serum
#19
Irene Bosch, Helena de Puig, Megan Hiley, Marc Carré-Camps, Federico Perdomo-Celis, Carlos F Narváez, Doris M Salgado, Dewahar Senthoor, Madeline O'Grady, Elizabeth Phillips, Ann Durbin, Diana Fandos, Hikaru Miyazaki, Chun-Wan Yen, Margarita Gélvez-Ramírez, Rajas V Warke, Lucas S Ribeiro, Mauro M Teixeira, Roque P Almeida, José E Muñóz-Medina, Juan E Ludert, Mauricio L Nogueira, Tatiana E Colombo, Ana C B Terzian, Patricia T Bozza, Andrea S Calheiros, Yasmine R Vieira, Giselle Barbosa-Lima, Alexandre Vizzoni, José Cerbino-Neto, Fernando A Bozza, Thiago M L Souza, Monique R O Trugilho, Ana M B de Filippis, Patricia C de Sequeira, Ernesto T A Marques, Tereza Magalhaes, Francisco J Díaz, Berta N Restrepo, Katerine Marín, Salim Mattar, Daniel Olson, Edwin J Asturias, Mark Lucera, Mohit Singla, Guruprasad R Medigeshi, Norma de Bosch, Justina Tam, Jose Gómez-Márquez, Charles Clavet, Luis Villar, Kimberly Hamad-Schifferli, Lee Gehrke
The recent Zika virus (ZIKV) outbreak demonstrates that cost-effective clinical diagnostics are urgently needed to detect and distinguish viral infections to improve patient care. Unlike dengue virus (DENV), ZIKV infections during pregnancy correlate with severe birth defects, including microcephaly and neurological disorders. Because ZIKV and DENV are related flaviviruses, their homologous proteins and nucleic acids can cause cross-reactions and false-positive results in molecular, antigenic, and serologic diagnostics...
September 27, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28937986/household-costs-of-hospitalized-dengue-illness-in-semi-rural-thailand
#20
Yesim Tozan, Pitcha Ratanawong, Maquines Odhiambo Sewe, Annelies Wilder-Smith, Pattamaporn Kittayapong
BACKGROUND: Dengue-related illness is a leading cause of hospitalization and death in Thailand and other Southeast Asian countries, imposing a major economic burden on households, health systems, and governments. This study aims to assess the economic impact of hospitalized dengue cases on households in Chachoengsao province in eastern Thailand. METHODS: We conducted a prospective cost-of-illness study of hospitalized pediatric and adult dengue patients at three public hospitals...
September 2017: PLoS Neglected Tropical Diseases
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