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Onset puberty

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https://www.readbyqxmd.com/read/28931070/atrazine-induced-epigenetic-transgenerational-inheritance-of-disease-lean-phenotype-and-sperm-epimutation-pathology-biomarkers
#1
Margaux McBirney, Stephanie E King, Michelle Pappalardo, Elizabeth Houser, Margaret Unkefer, Eric Nilsson, Ingrid Sadler-Riggleman, Daniel Beck, Paul Winchester, Michael K Skinner
Ancestral environmental exposures to a variety of environmental toxicants and other factors have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The current study examined the potential transgenerational actions of the herbicide atrazine. Atrazine is one of the most commonly used herbicides in the agricultural industry, in particular with corn and soy crops. Outbred gestating female rats were transiently exposed to a vehicle control or atrazine. The F1 generation offspring were bred to generate the F2 generation and then the F2 generation bred to generate the F3 generation...
2017: PloS One
https://www.readbyqxmd.com/read/28926121/new-pediatric-percentiles-of-liver-enzyme-serum-levels-alt-ast-ggt-effects-of-age-sex-bmi-and-pubertal-stage
#2
Sarah Bussler, Mandy Vogel, Diana Pietzner, Kristian Harms, Theresa Buzek, Melanie Penke, Norman Händel, Antje Körner, Ulrich Baumann, Wieland Kiess, Gunter Flemming
The present study aims to clarify the effects of sex, age, BMI and puberty on transaminase serum levels in children and adolescents and to provide new age- and sex-related percentiles for alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamyltransferase (GGT). Venous blood and anthropometric data were collected from 4,126 cases. Excluded were cases of participants with potential hepatotoxic medication, with evidence of potential illness at the time of blood sampling and non-normal BMI (BMI < 10(th) or > 90(th) )...
September 19, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28925408/liver-volume-and-hepatic-adiposity-in-childhood-relations-to-body-growth-and-visceral-fat
#3
R Malpique, J Bassols, A López-Bermejo, M Diaz, F Villarroya, J Pavia, A Congo, F de Zegher, L Ibáñez
BACKGROUND AND OBJECTIVE: The sequence of prenatal growth restraint and postnatal catch-up growth may lead to hepato-visceral adiposity, insulin resistance and low-grade inflammation before the onset of puberty. In prepubertal children born appropriate for gestational age (AGA) or small for gestational age (SGA), we assessed potential relationships between the aforementioned sequence and liver volume. SUBJECTS/METHODS: The study population consisted of 86 children (41 AGA and 45 SGA with catch-up growth; age (mean±s...
August 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28924487/a-novel-stop-mutation-p-gln22-of-dax1-nr0b1-results-in-late-onset-x-linked-adrenal-hypoplasia-congenita
#4
Judith Gerards, Michael M Ritter, Elke Kaminsky, Andreas Gal, Wolfgang Hoeppner, Marcus Quinkler
DAX1 (NR0B1) is an orphan nuclear receptor, which plays an important role in development and function of the adrenal glands and gonads. Mutations in DAX1 cause X-linked adrenal hypoplasia congenita (X-linked AHC), which is characterized by adrenal insufficiency (AI) and hypogonadotropic hypogonadism (HHG). Affected boys present with adrenal failure usually in childhood and, later in life, with delayed puberty. However, patients with a late-onset form of X-linked AHC have also been described in the past years...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28923047/prepubertal-onset-of-slipped-capital-femoral-epiphysis-associated-with-hypothyroidism-a-case-report-and-literature-review
#5
Saori Kadowaki, Tomohiro Hori, Hideki Matsumoto, Kaori Kanda, Michio Ozeki, Yu Shirakami, Norio Kawamoto, Hidenori Ohnishi, Toshiyuki Fukao
BACKGROUND: Slipped capital femoral epiphysis (SCFE) is a common hip disorder characterized by displacement of the capital femoral epiphysis from the metaphysic through the femoral epiphyseal plate. SCFE usually occurs during puberty, with obesity a common risk factor. We experienced a rare case of SCFE associated with hypothyroidism in a prepubescent patient who was not obese. CASE PRESENTATION: The patient was an 8-year-old boy suffering from bilateral SCFE with hypothyroidism...
September 18, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28916209/towards-new-strategies-to-manage-livestock-reproduction-using-kisspeptin-analogs
#6
M Beltramo, C Decourt
The discovery of the hypothalamic neuropeptide kisspeptin and its receptor (KISS1R) have dramatically improved our knowledge about the central mechanisms controlling reproduction. Kisspeptin neurons could be considered the hub where internal and external information controlling reproduction converge. The information is here elaborated and the command dispatched to GnRH neurons, the final output of the brain system controlling reproduction. Several studies have shown that in mammals administration of kisspeptin could finely modulate many aspects of reproduction from puberty to ovulation...
September 12, 2017: Theriogenology
https://www.readbyqxmd.com/read/28912783/sex-differences-in-asthma-a-key-role-of-androgen-signaling-in-group-2-innate-lymphoid-cells
#7
REVIEW
Sophie Laffont, Eve Blanquart, Jean-Charles Guéry
Infectious diseases, autoimmune diseases, and also allergy differentially affect women and men. In general, women develop strongest immune responses and thus the proportion of infected individuals and the severity of many viral, bacterial, or parasitic infections are increased in men. However, heightened immunity in women makes them more susceptible than men to autoimmunity and allergy. While sex differences in immunity are well documented, little is known about the cellular and molecular mechanisms underlying these immunological differences, particularly in allergic asthma...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28902184/the-relationship-between-infancy-growth-rate-and-the-onset-of-puberty-in-both-genders
#8
Banu Kucukemre Aydin, Esra Devecioglu, Alev Kadioglu, Ayca Erkin Cakmak, Sezin Kisabacak, Gulbin Gokcay, Firdevs Bas, Sukran Poyrazoglu, Ruveyde Bundak, Feyza Darendeliler
BackgroundIn this study, we examined the hypothesis that weight gain and linear growth during the first years of life influence the onset of puberty both in girls and in boys.MethodsA cohort of 157 healthy children, aged 6-9 years, was evaluated and their growth patterns were analyzed retrospectively. Repeated measures mixed model was used to examine the longitudinal anthropometric data.ResultsGirls with pubertal signs were heavier than their peers starting at 9 months of age (P=0.02), and the difference became more evident over time (P<0...
September 13, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28891963/the-effect-of-bisphenol-a-on-puberty-a-critical-review-of-the-medical-literature
#9
REVIEW
Alberto Leonardi, Marta Cofini, Donato Rigante, Laura Lucchetti, Clelia Cipolla, Laura Penta, Susanna Esposito
Many scientific studies have revealed a trend towards an earlier onset of puberty and have disclosed an increasing number of children that display precocious puberty. As an explanation, some authors have considered the global socio-economic improvement across different populations, and other authors have considered the action of endocrine disrupting chemicals (EDCs). Among these, bisphenol A (BPA), an aromatic compound largely used worldwide as a precursor of some plastics and chemical additives, is well known for its molecular oestrogen-like and obesogenic actions...
September 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28891935/alteration-of-mammary-gland-development-and-gene-expression-by-in-utero-exposure-to-cadmium
#10
Daniela A Parodi, Morgan Greenfield, Claire Evans, Anna Chichura, Alexandra Alpaugh, James Williams, Kedra C Cyrus, Mary Beth Martin
Environmental exposure to estrogens and estrogen like contaminants during early development is thought to contribute to the risk of developing breast cancer primarily due to an early onset of puberty; however, exposure during key developing windows may also influence the risk of developing the disease. The goal of this study was to ask whether in utero exposure to the metalloestrogen cadmium alters mammary gland development due to acceleration of puberty onset or to an effect on early development of the mammary gland...
September 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28890442/marked-geographic-patterns-in-the-incidence-of-idiopathic-central-precocious-puberty-a-nationwide-study-in-france
#11
Joëlle Le Moal, Annabel Rigou, Alain Le Tertre, Perrine Decrouy-Chanel, Juliane Leger, Jean-Claude Carel
OBJECTIVES: Precocious puberty seems to be increasing but epidemiological data are scarce. Our objective was to improve the epidemiologic knowledge on this disease, in the context of a suspected role of endocrine disruptor chemicals exposure. We analyzed the national incidence and spatial trends of idiopathic central precocious puberty in France in 2011-2013 in a cross-sectional descriptive study. DESIGN: We used an indicator based on treatment reimbursements recorded in the national insurance database, in boys less than 10 years and girls less than nine years old...
September 10, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28888607/effect-of-increasing-amounts-of-milk-replacer-powder-added-to-whole-milk-on-postweaning-performance-reproduction-glucose-metabolism-and-mammary-fat-pad-in-dairy-heifers
#12
C F A Lage, R A Azevedo, F S Machado, M M Campos, L G R Pereira, T R Tomich, B C Carvalho, B R C Alves, G B Santos, F Z Brandão, S G Coelho
The aim of this study was to evaluate the effects of increasing the total solids (TS) content of liquid feed, by adding increasing amounts of milk replacer powder to whole milk, on age at puberty and postweaning performance, glucose metabolism, and mammary fat pad of dairy heifers. Crossbreed Holstein × Gyr heifers (n = 58) were distributed into 4 different treatments during the preweaning period. Treatments consisted of liquid feeds with TS content of 12.5 (actual TS = 13.5 ± 0.53%; n = 15), 15.0 (actual TS = 16...
September 6, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28873088/identifying-genetic-variants-that-affect-viability-in-large-cohorts
#13
Hakhamanesh Mostafavi, Tomaz Berisa, Felix R Day, John R B Perry, Molly Przeworski, Joseph K Pickrell
A number of open questions in human evolutionary genetics would become tractable if we were able to directly measure evolutionary fitness. As a step towards this goal, we developed a method to examine whether individual genetic variants, or sets of genetic variants, currently influence viability. The approach consists in testing whether the frequency of an allele varies across ages, accounting for variation in ancestry. We applied it to the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort and to the parents of participants in the UK Biobank...
September 2017: PLoS Biology
https://www.readbyqxmd.com/read/28870491/the-effect-of-neonatal-immune-challenge-on-reproduction-by-altering-intraovarian-kisspeptin-gpr54-system-in-the-rat
#14
Bin-Qiao Wang, Yuan-Yuan Chen, Xiao-Xiao Lan, Zhi-Yang Zhou, Xin-Xin Xu, Xue-Qing Wu
Immune challenge in early life has been observed to influence the long-term reproductive dysfunction. On PNDs 3 and 5, female offsprings were administered with LPS (50μg/kg, i.p.) or saline. Vaginal opening was recorded, and oestrous cyclicity was monitored immediately post puberty and again at 56-70 days. At 10 weeks of age, the ovaries were removed for immunostaining and RNA analysis. Neonatal exposure to LPS resulted in a significant delay puberty onset as well as destroyed expression of ovulation related genes...
September 8, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28859627/genetics-of-depressive-symptoms-in-adolescence
#15
Hannah Sallis, Jonathan Evans, Robyn Wootton, Eva Krapohl, Albertine J Oldehinkel, George Davey Smith, Lavinia Paternoster
BACKGROUND: Despite many attempts to understand the genetic architecture of depression, little progress has been made. The majority of these studies, however, have been carried out in adults and do not account for the potential influence of development. METHODS: The Avon Longitudinal Study of Parents and Children (ALSPAC) is a longitudinal pregnancy cohort which recruited participants between April 1991 and December 1992. Analyses were replicated in two independent European cohorts...
August 31, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28859283/plasma-anti-m%C3%A3-llerian-hormone-profile-in-heifers-from-birth-through-puberty-and-relationship-with-puberty-onset
#16
Hossam El-Sheikh Ali, Go Kitahara, Toru Takahashi, Shogo Mido, Mohammed Sadawy, Ikuo Kobayashi, Koichiro Hemmi, Takeshi Osawa
The current study aimed to define the plasma profile of anti-Müllerian hormone (AMH) and follicle stimulating hormone (FSH) in heifers during postnatal life until achieving puberty, as defined by plasma progesterone (P4) profile, to demonstrate a relationship between AMH and age of puberty onset. Blood samples collected from 11 Japanese Black female calves within 1 week after birth (W 0) and then biweekly until the sixth week after puberty (WP 6) were assayed for AMH, FSH, and P4. The heifers were classified into two groups based on age of puberty onset: ≤42 weeks (early puberty group; EP, n = 4) and ≥44 weeks (late puberty group; LP, n = 7)...
July 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28856494/typical-pubertal-timing-in-an-australian-population-of-girls-and-boys-with-autism-spectrum-disorder
#17
Tamara May, Ken C Pang, Michele A O'Connell, Katrina Williams
Secondary data analyses from the Longitudinal Study of Australian Children Kindergarten cohort were performed to understand any alterations in pubertal timing in Autism Spectrum Disorder (ASD) in a population sample. Timing of parent-reported pubertal events (ages 8-9, 10-11, 12-13 years), and self-report (14-15 years; N = 3454 no ASD, N = 94 with ASD) included breast development, menses, skin changes, growth spurt, body hair, deepening voice and facial hair. Survival analyses and Cox regression controlling for covariates showed no evidence of altered pubertal onset amongst males with ASD...
August 30, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28854721/chronic-combined-hyperandrogenemia-and-western-style-diet-in-young-female-rhesus-macaques-causes-greater-metabolic-impairments-compared-to-either-treatment-alone
#18
C A True, D L Takahashi, S E Burns, E C Mishler, K R Bond, M C Wilcox, A R Calhoun, L A Bader, T A Dean, N D Ryan, O D Slayden, J L Cameron, R L Stouffer
STUDY QUESTION: Does developmental exposure to the combination of hyperandrogenemia and western-style diet (WSD) worsen adult metabolic function compared to either treatment alone? SUMMARY ANSWER: Young female rhesus macaques treated for 3 years, beginning at menarche, with combined testosterone (T) and WSD have increased weight gain and insulin resistance compared to controls and animals treated with either T or WSD alone. WHAT IS KNOWN ALREADY: Hyperandrogenemia is a well-established component of polycystic ovary syndrome (PCOS) and can be observed in peripubertal girls, indicating a potential pubertal onset of the disease...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28846730/role-of-amygdala-kisspeptin-in-pubertal-timing-in-female-rats
#19
Daniel A Adekunbi, Xiao Feng Li, Shengyun Li, Olufeyi A Adegoke, Bolanle O Iranloye, Ayodele O Morakinyo, Stafford L Lightman, Paul D Taylor, Lucilla Poston, Kevin T O'Byrne
To investigate the mechanism by which maternal obesity disrupts reproductive function in offspring, we examined Kiss1 expression in the hypothalamic arcuate (ARC) and anteroventral periventricular (AVPV) nuclei, and posterodorsal medial amygdala (MePD) of pre-pubertal and young adult offspring. Sprague-Dawley rats were fed either a standard or energy-dense diet for six weeks prior to mating and throughout pregnancy and lactation. Male and female offspring were weaned onto normal diet on postnatal day (pnd) 21...
2017: PloS One
https://www.readbyqxmd.com/read/28845625/impact-of-carbohydrate-restriction-on-healthy-adolescent-development
#20
Hannah M Richmond, David M Duriancik
Carbohydrate-restricted diets are known for their impact on weight loss; however, research is still required to determine if low-carbohydrate diets are safe for adolescents. Carbohydrates directly stimulate an insulin response, and studies have recently shown that insulin and binding to respective insulin receptors (IRs) are critical in Kisspeptin (Kiss1) neuronal development. These neurons directly stimulate gonadotropin-releasing hormone, which activates the pituitary-gonadal axis during puberty. This information suggests that carbohydrate restriction may delay pubertal development in adolescents due to the impact on insulin and Kiss1 transcription...
September 2017: Pediatric Endocrinology Reviews: PER
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