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Steroid profiling

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https://www.readbyqxmd.com/read/29349906/pregnancy-greatly-affect-the-steroidal-module-of-the-athlete-biological-passport
#1
Jenny Mullen, Yifat Gadot, Emma Eklund, Alexander Andersson, Jenny J Schulze, Magnus Ericsson, Angelica Lindén Hirschberg, Anders Rane, Lena Ekström
Concentrations of urinary steroids are measured in anti-doping test programs to detect doping with endogenous steroids. These concentrations are combined into ratios and followed over time in the steroidal module of the Athlete Biological Passport (ABP). The most important ratio in the ABP is the testosterone/epitestosterone (T/E) ratio but this ratio is subject to intra-individual variations, especially large in women, which complicates interpretation. In addition there are other factors affecting T/E, pregnancy for example is known to affect the urinary excretion rate of epitestosterone and hence the T/E ratio...
January 18, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29349513/3d-qsar-study-of-steroidal-and-azaheterocyclic-human-aromatase-inhibitors-using-quantitative-profile-of-protein-ligand-interactions
#2
Sehan Lee, Mace G Barron
Aromatase is a member of the cytochrome P450 superfamily responsible for a key step in the biosynthesis of estrogens. As estrogens are involved in the control of important reproduction-related processes, including sexual differentiation and maturation, aromatase is a potential target for endocrine disrupting chemicals as well as breast cancer therapy. In this work, 3D-QSAR combined with quantitative profile of protein-ligand interactions was employed in the identification and characterization of critical steric and electronic features of aromatase-inhibitor complexes and the estimation of their quantitative contribution to inhibition potency...
January 18, 2018: Journal of Cheminformatics
https://www.readbyqxmd.com/read/29346086/the-dynamics-of-a-serum-steroid-profile-after-stimulation-with-intravenous-acth
#3
Johanna M Lindner, Anna Catharina Suhr, Stefanie H Grimm, Patrick Möhnle, Michael Vogeser, Josef Briegel
BACKGROUND: Stimulation with intravenous adrenocorticotropic hormone (ACTH) is a widely used diagnostic procedure to characterize the adrenocortical function. Currently, the response of serum cortisol, mainly quantified by immunoassays, is the only established read-out of this test. By using liquid chromatography coupled with mass spectrometry (LC-MS/MS) simultaneous determination of several steroids that respond to ACTH stimulation is now possible. The aim of this study was to further characterize the typical effect of exogenous ACTH (250 mg) on a LC-MS/MS-serum steroid profile...
December 26, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29341936/rheumatic-manifestations-among-cancer-patients-treated-with-immune-checkpoint-inhibitors
#4
REVIEW
Merav Lidar, Eitan Giat, Daniela Garelick, Yuval Horowitz, Howard Amital, Yael Steinberg-Silman, Jacob Shachter, Ronnie Shapira-Frommer, Gal Markel
BACKGROUND: The use of immune checkpoint inhibitors (ICI) has grown incessantly since they were first approved in 2014. These monoclonal antibodies inhibit T cell activation, yielding a dramatic tumor response with improved survival. However, immunotherapy is frequently hampered by immune adverse events (iAE) such as hypophysitis, colitis, hepatitis, pneumonitis and rash. Until recently, rheumatic side effects were only infrequently reported. Aim To describe the rheumatic manifestations encountered among patients treated with ICIs in a large tertiary cancer center in Israel METHODS: The cancer center's patient registry was screened for patients who had ever been treated with ipilimumab, pembrolizumab and/or nivolumab with relevant data gathered from clinical charts...
January 13, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29336082/metabolomics-study-of-cultivated-bulbus-fritillariae-cirrhosae-at-different-growth-stages-using-uhplc-qtof-ms-coupled-with-multivariate-data-analysis
#5
Zhao Geng, YiFei Liu, Yan Gou, QinMei Zhou, ChengJun He, Li Guo, Juan Zhou, Liang Xiong
INTRODUCTION: Bulbus fritillariae cirrhosae (known as Chuān bèi mǔ in China, BFC) contain fritillaria steroidal alkaloids as the bioactive ingredients and are widely used as traditional Chinese medicine for the treatment of cough and phlegm. Due to limited wild resources, the cultivated species are becoming predominantly used in Chinese traditional medicine markets. OBJECTIVE: To assess the impact of different growth stages on the alkaloids of cultivated BFC and establish a reference for quality control and guidance for appropriate harvesting practices...
January 15, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29334634/equine-in-vivo-derived-metabolites-of-the-sarm-lgd-4033-and-comparison-with-human-and-fungal-metabolites
#6
Annelie Hansson, Heather Knych, Scott Stanley, Emma Berndtson, Liora Jackson, Ulf Bondesson, Mario Thevis, Mikael Hedeland
LGD-4033 has been found in human doping control samples and has the potential for illicit use in racehorses as well. It belongs to the pharmacological class of selective androgen receptor modulators (SARMs) and can stimulate muscle growth, much like anabolic steroids. However, SARMs have shown superior side effect profiles compared to anabolic steroids, which arguably makes them attractive for use by individuals seeking an unfair advantage over their competitors. The purpose of this study was to investigate the metabolites formed from LGD-4033 in the horse in order to find suitable analytical targets for doping controls...
December 7, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29332424/salivary-metabolomics-profile-of-patients-with-recurrent-aphthous-ulcer-as-revealed-by-liquid-chromatography-tandem-mass-spectrometry
#7
Yantao Li, Daoming Wang, Chunwei Zeng, Yichen Liu, Guangyuan Huang, Zhanlong Mei
Objective We compared the salivary nontargeted metabolite profiles between patients with recurrent aphthous ulcer (RAU) and healthy individuals to investigate the metabolic alterations associated with RAU. Methods Saliva samples were collected from 45 patients with RAU and 49 healthy individuals, and the salivary metabolites were quantified using liquid chromatography-tandem mass spectrometry. The metabolomic profiles were then analyzed using multivariate and univariate statistical methods, and enrichment of the metabolites in various biological pathways was assessed...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29331315/ethnobotany-phytochemistry-and-pharmacology-of-arctotis-arctotoides-l-f-o-hoffm-a-review
#8
REVIEW
Md Moshfekus Saleh-E-In, Johannes Van Staden
ETHNOPHARMACOLOGICAL RELEVANCE: Arctotis arctotoides (Asteraceae) is part of the genus Arctotis. Arctotis is an African genus of approximately 70 species that occur widely in the African continent with diverse medicinal values. This plant is used for the treatment of indigestion and catarrh of the stomach, epilepsy, topical wounds and skin disorders among the ethnic groups in South Africa and reported to have a wide spectrum of pharmacological properties. AIM OF THE REVIEW: The aim of the present review is to appraise the botany, traditional uses, phytochemistry, pharmacological potential, analytical methods and safety issues of A...
January 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29330226/mitotane-treatment-in-patients-with-metastatic-testicular-leydig-cell-tutor-associated-with-severe-androgen-excess
#9
Vasileios Chortis, Nicholas J Johal, Irina Bancos, Matthew Evans, Kassiani Skordilis, Peter Guest, Michael H Cullen, Emilio Porfiri, Wiebke Arlt
Mitotane (o,p'DDD) is established in the adjuvant and advanced stage treatment of adrenocortical carcinoma and counteracts both tumour growth and tumour-related steroid production. Both the adrenal glands and the gonads are steroidogenically active organs and share a common embryogenic origin. Here we describe the effects of mitotane in two patients with metastatic Leydig cell tumour (LCT) of the testes and associated severe androgen excess (serum testosterone 93 and 88 nmol/l, respectively; male reference range 7-27 nmol/L)...
January 12, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29328914/rewiring-of-the-fruit-metabolome-in-tomato-breeding
#10
Guangtao Zhu, Shouchuang Wang, Zejun Huang, Shuaibin Zhang, Qinggang Liao, Chunzhi Zhang, Tao Lin, Mao Qin, Meng Peng, Chenkun Yang, Xue Cao, Xu Han, Xiaoxuan Wang, Esther van der Knaap, Zhonghua Zhang, Xia Cui, Harry Klee, Alisdair R Fernie, Jie Luo, Sanwen Huang
Humans heavily rely on dozens of domesticated plant species that have been further improved through intensive breeding. To evaluate how breeding changed the tomato fruit metabolome, we have generated and analyzed a dataset encompassing genomes, transcriptomes, and metabolomes from hundreds of tomato genotypes. The combined results illustrate how breeding globally altered fruit metabolite content. Selection for alleles of genes associated with larger fruits altered metabolite profiles as a consequence of linkage with nearby genes...
January 11, 2018: Cell
https://www.readbyqxmd.com/read/29316826/the-role-of-metabolomic-markers-for-patients-with-infectious-diseases-implications-for-risk-stratification-and-therapeutic-modulation
#11
Seline Zurfluh, Thomas Baumgartner, Marc A Meier, Manuel Ottiger, Alaadin Voegeli, Luca Bernasconi, Peter Neyer, Beat Mueller, Philipp Schuetz
Metabolomics is a rapidly growing area of research. Metabolomic markers can provide information about the interaction of different organ systems, and thereby improve the understanding of physio-pathological processes, disease risk, prognosis and therapy responsiveness in a variety of diseases. Areas covered: In this narrative review of recent clinical studies investigating metabolomic markers in adult patients presenting with acute infectious disease, we mainly focused on patients with sepsis and lower respiratory tract infections...
January 9, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29315590/brassinosteroids-regulate-glucosinolate-biosynthesis-in-arabidopsis-thaliana
#12
Ji Hyea Lee, Jeongyeo Lee, HyeRan Kim, Won Byoung Chae, Sun-Ju Kim, Yong Pyo Lim, Man-Ho Oh
Plants must constantly adjust their growth and defense responses to deal with the wide variety of stresses they encounter in their environment. Among phytohormones, brassinosteroids (BRs) are an important group of plant steroid hormones involved in numerous aspects of the plant lifecycle including growth, development, and responses to various stresses including insects. Here, we show that BRs regulate glucosinolate (GS) biosynthesis and function in insect herbivory. Preference tests and larval feeding experiments using the generalist herbivore, diamondback moth (Plutella xylostella), revealed that the larvae of this moth prefer to feed on Arabidopsis thaliana brassinosteroid insensitive 1 (bri1-5) plants than on wild-type Ws-2 or BRI1-Flag (bri1-5 background) transgenic plants, which leads an increase in larval weight...
January 5, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29305667/a-pilot-study-comparing-the-metabolic-profiles-of-elite-level-athletes-from-different-sporting-disciplines
#13
Fatima Al-Khelaifi, Ilhame Diboun, Francesco Donati, Francesco Botrè, Mohammed Alsayrafi, Costas Georgakopoulos, Karsten Suhre, Noha A Yousri, Mohamed A Elrayess
BACKGROUND: The outstanding performance of an elite athlete might be associated with changes in their blood metabolic profile. The aims of this study were to compare the blood metabolic profiles between moderate- and high-power and endurance elite athletes and to identify the potential metabolic pathways underlying these differences. METHODS: Metabolic profiling of serum samples from 191 elite athletes from different sports disciplines (121 high- and 70 moderate-endurance athletes, including 44 high- and 144 moderate-power athletes), who participated in national or international sports events and tested negative for doping abuse at anti-doping laboratories, was performed using non-targeted metabolomics-based mass spectroscopy combined with ultrahigh-performance liquid chromatography...
January 5, 2018: Sports Medicine—Open
https://www.readbyqxmd.com/read/29301092/metabolomic-profiling-of-bovine-oviductal-fluid-across-the-oestrous-cycle-using-proton-nuclear-magnetic-resonance-spectroscopy
#14
Julie Lamy, Julie Gatien, Florine Dubuisson, Lydie Nadal-Desbarats, Pascal Salvetti, Pascal Mermillod, Marie Saint-Dizier
In the present study we tested whether regulation of the metabolome in bovine oviductal fluid depended on the stage of the oestrous cycle, the side relative to ovulation and local concentrations of steroid hormones. Luminal fluid samples from both oviducts were collected in the preovulatory, postovulatory, mid- and late luteal phases, from cyclic cows at a local abattoir (18-27 cows per stage and side). The metabolomes were assessed by proton nuclear magnetic resonance spectroscopy (H-NMR). In all, 39 metabolites were identified, among which the amino acid glycine and the energy substrates lactate and myoinositol were the most abundant at all stages...
January 5, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29300474/identification-of-morpholino-2h-pyrido-3-2-b-1-4-oxazin-3-4h-ones-as-non-steroidal-mineralocorticoid-antagonists
#15
David W Piotrowski, Kentaro Futatsugi, Agustin Casimiro-Garcia, Liuqing Wei, Matthew Sammons, Michael Herr, Wenhua Jiao, Sophie Y Lavergne, Steven B Coffey, Stephen W Wright, Kun Song, Paula M Loria, Mary Ellen Banker, Donna N Petersen, Jonathan Bauman
A novel series of morpholine-based non-steroidal mineralocorticoid receptor antagonists is reported. Starting from a pyrrolidine HTS hit 9 that possessed modest potency but excellect selectivity versus related nuclear hormone receptors, a series of libraries led to identification of morpholine lead 10. After further optimization, cis disubstituted morpholine 22 was discovered, which showed a 45-fold boost in binding affinity and corresponding functional potency compared to 13. While 22 had high clearance in rat, it provided sufficient exposure at high doses to favorably assess in vivo efficacy (increased urinary Na+/K+ ratio) and safety...
January 4, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29298401/penile-lichen-sclerosus-treated-with-1927%C3%A2-nm-thulium-fiber-laser-and-photodynamic-therapy-a-new-possible-therapeutic-approach
#16
Santo Raffaele Mercuri, Pina Brianti, Antonio Foti, Marco Bartolucci, Annunziata Dattola, Steven Paul Nisticò
OBJECTIVE: We treated two patients with recalcitrant lichen sclerosus (LS) of the penis with a combination of 1927 nm thulium fiber laser and methyl-aminolevulinate (MAL) photodynamic therapy (PDT). BACKGROUND DATA: Therapy of LS is based on topical potent steroids, emollients, and topical calcineurin inhibitors. Circumcision is effective, but not always accepted. PDT represents a valid therapeutic option in refractory cases, but there are no reports about the association with 1927 nm thulium laser in the treatment of this pathology...
January 3, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29297822/early-onset-of-the-reproductive-season-in-captive-white-tailed-deer-odocoileus-virginianus-veraecrucis-in-eastern-mexico
#17
Concepción Ahuja-Aguirre, Omar Pérez-Gutiérrez, Lorena López-deBuen, Susana Rojas-Maya, Felipe Montiel-Palacios
The white-tailed deer ( Odocoileus virginianus) inhabits a wide latitudinal range in the Americas. Deer species dwelling throughout wide latitudinal ranges have developed subspecies with variations in their reproductive seasonality. In northern subspecies of white-tailed deer, such as those from Canada and the United States, the breeding season occurs from October through December. Odocoileus virginianus veraecrucis is a subspecies that inhabits eastern Mexico, and because its reproductive season has not been studied, it is believed to be similar to that from northern subspecies...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29289577/longitudinal-serum-and-urine-steroid-metabolite-profiling-in-a-46-xy-infant-with-prenatally-identified-por-deficiency
#18
Hiroyuki Ono, Chikahiko Numakura, Keiko Homma, Tomonobu Hasegawa, Seiji Tsutsumi, Fumiko Kato, Yasuko Fujisawa, Maki Fukami, Tsutomu Ogata
Although POR deficiency (PORD) is assumed to be accompanied by excessive placental androgen accumulation and enhanced adrenal and testicular androgen production via the backdoor pathway as well as compromised testicular androgen production via the frontdoor pathway, there is no direct evidence for the flux of excessive placental androgens into the fetal circulation and for the production of dihydrotestosterone (DHT) via the backdoor pathway. We examined longitudinal serum and urine steroid metabolite profiles in a 46,XY infant with PORD who was prenatally identified because of the progressive fetal masculinization and maternal virilization from the mid-gestation and the presence of fetal radio-humeral synostosis and was confirmed to have compound heterozygous mutations of POR (p...
December 28, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29288880/diuretics-combined-with-compression-in-resistant-limb-edema-of-advanced-disease-a-case-series-report
#19
Tomasz Gradalski
INTRODUCTION: The extremity edema of advanced disease is a common, multifactorial feature, which impairs patient activities and quality of life. The most frequently chosen management is based on combined decongestive physiotherapy or pharmacotherapy (with diuretics or steroids). Subcutaneous lymphatic drainage in refractory edema may decrease the swelling, prevent spontaneous lymphorrhoea but also increase the risk of infection. Safe and effective conservative management in diuretics resistant edemas is lacking...
December 27, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29283449/oxaprozin-prodrug-as-safer-nonsteroidal-anti-inflammatory-drug-synthesis-and-pharmacological-evaluation
#20
Jaya P Peesa, Lakshmana R Atmakuri, Prasanna R Yalavarthi, Basaveswara R Mandava Venkata, Arun Rasheed, Vengalrao Pachava
Oxaprozin is a popular non-steroidal anti-inflammatory drug (NSAID) and its chronic oral use is clinically restricted due to its gastrointestinal (GI) complications. In order to circumvent the GI complications, oxaprozin was amended as a prodrug in a one-pot reaction using N,N-carbonyldiimidazole as an activating agent. Dextran of average molecular weight (60,000-90,000 Da) was exploited as a carrier in the process of oxaprozin prodrug production by esterification. The structural profiles of the synthesized oxaprozin prodrug were characterized by FT-IR and NMR spectroscopy...
December 28, 2017: Archiv der Pharmazie
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