Thomas Leclerc, Raphael Levy, Arnault Tauziède-Espariat, Charles-Joris Roux, Kevin Beccaria, Thomas Blauwblomme, Stéphanie Puget, Jacques Grill, Christelle Dufour, Léa Guerrini-Rousseau, Samuel Abbou, Stéphanie Bolle, Alexandre Roux, Johan Pallud, Corentin Provost, Catherine Oppenheim, Pascale Varlet, Nathalie Boddaert, Volodia Dangouloff-Ros
OBJECTIVES: Posterior fossa ependymoma group A (EPN_PFA) and group B (EPN_PFB) can be distinguished by their DNA methylation and give rise to different prognoses. We compared the MRI characteristics of EPN_PFA and EPN_PFB at presentation. METHODS: Preoperative imaging of 68 patients with posterior fossa ependymoma from two centers was reviewed by three independent readers, blinded for histomolecular grouping. Location, tumor extension, tumor volume, hydrocephalus, calcifications, tissue component, enhancement or diffusion signal, and histopathological data (cellular density, calcifications, necrosis, mitoses, vascularization, and microvascular proliferation) were compared between the groups...
September 2, 2023: European Radiology