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https://www.readbyqxmd.com/read/23583249/left-atrial-appendage-closure-with-the-watchman-device-in-patients-with-a-contraindication-for-oral-anticoagulation-the-asap-study-asa-plavix-feasibility-study-with-watchman-left-atrial-appendage-closure-technology
#1
MULTICENTER STUDY
Vivek Y Reddy, Sven Möbius-Winkler, Marc A Miller, Petr Neuzil, Gerhard Schuler, Jens Wiebe, Peter Sick, Horst Sievert
OBJECTIVES: The purpose of this study was to assess the safety and efficacy of left atrial appendage (LAA) closure in nonvalvular atrial fibrillation (AF) patients ineligible for warfarin therapy. BACKGROUND: The PROTECT AF (Watchman Left Atrial Appendage System for Embolic Protection in Patients With Atrial Fibrillation) trial demonstrated that LAA closure with the Watchman device (Boston Scientific, Natick, Massachusetts) was noninferior to warfarin therapy. However, the PROTECT AF trial only included patients who were candidates for warfarin, and even patients randomly assigned to the LAA closure arm received concomitant warfarin for 6 weeks after Watchman implantation...
June 25, 2013: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/16151033/effects-of-clopidogrel-and-aspirin-in-combination-versus-aspirin-alone-on-platelet-activation-and-major-receptor-expression-in-patients-after-recent-ischemic-stroke-for-the-plavix-use-for-treatment-of-stroke-pluto-stroke-trial
#2
RANDOMIZED CONTROLLED TRIAL
Victor L Serebruany, Alex I Malinin, Wendy Ziai, Alex N Pokov, Deepak L Bhatt, Mark J Alberts, Dan F Hanley
BACKGROUND AND PURPOSE: Clopidogrel is widely used in patients after recent ischemic stroke; however, its ability to yield additional antiplatelet protection on top of aspirin has never been explored in a controlled study. To determine whether clopidogrel with aspirin (C+ASA) will produce more potent platelet inhibition than aspirin alone (ASA) in patients after ischemic stroke, we conducted the Plavix Use for Treatment of Stroke trial. METHODS: Seventy patients after ischemic stroke were randomly assigned to C+ASA or ASA groups...
October 2005: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/14564328/effects-of-clopidogrel-and-aspirin-combination-versus-aspirin-alone-on-platelet-aggregation-and-major-receptor-expression-in-patients-with-heart-failure-the-plavix-use-for-treatment-of-congestive-heart-failure-pluto-chf-trial
#3
RANDOMIZED CONTROLLED TRIAL
Victor L Serebruany, Alex I Malinin, Scott D Jerome, David R Lowry, Athol W Morgan, David C Sane, Jean-François Tanguay, Steven R Steinhubl, Christopher M O'connor
BACKGROUND: Persistent platelet activation may contribute to thrombotic events in patients with congestive heart failure (CHF). Chronic use of mild platelet inhibitors could therefore represent an independent avenue to improve morbidity, mortality, and quality of life in this expanding population. Although clopidogrel is widely used in patients with acute coronary syndromes and ischemic stroke, the ability of this novel ADP-receptor antagonist to inhibit platelet function in patients with CHF is unknown...
October 2003: American Heart Journal
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