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https://www.readbyqxmd.com/read/28749056/on-legalizing-physician-assisted-death-for-dementia
#1
Rebecca Dresser
Last November, soon after Colorado became the latest state to authorize physician-assisted suicide, National Public Radio's The Diane Rehm Show devoted a segment to legalization of "physician assistance in dying," a label that refers to both physician-assisted suicide and voluntary active euthanasia. Although the segment initially focused on PAD in the context of terminal illness in general, it wasn't long before PAD's potential application to dementia patients came up. A caller said that her mother had Alzheimer's disease and was being cared for at great expense...
July 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28748774/exposure-to-parental-psychopathology-and-offspring-s-risk-of-suicide-related-thoughts-and-behaviours-a-systematic-review
#2
S M Goodday, J Shuldiner, S Bondy, A E Rhodes
AIMS: The primary objective of this systematic review was to identify and synthesise analytic studies examining the association between exposure to parental psychopathology in childhood and the nature of subsequent suicide-related thoughts (SRT) and suicide-related behaviour (SRB) (severity of ideation, planned/unplanned attempts/lethality) and to describe the direction, and magnitude of associations. The secondary objective was to determine if the associations from the primary objective differ by the type(s) and timing of parental psychopathology, sex/gender of the parent and child and is mediated by child psychiatric symptoms and family functioning...
July 27, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28748710/national-suicide-prevention-local-mental-health-resources-and-suicide-rates-in-japan
#3
Miharu Nakanishi, Kaori Endo
BACKGROUND: Suicide rates in Japan are relatively high in OECD countries. A national fund to help local authorities implement suicide prevention programs was launched in 2009. The national suicide prevention project was transferred from the Cabinet Office to the Ministry of Health, Labor, and Welfare on April 2016, with a greater focus on mental health promotion by local governments. AIMS: The aim of the present study was to (a) identify local authorities' implementation of suicide prevention programs in terms of local health policies, and (b) examine the associations between local health resources and suicide rates in Japan...
July 27, 2017: Crisis
https://www.readbyqxmd.com/read/28748608/four-years-comparative-follow-up-evaluation-of-community-based-step-down-and-residential-specialist-psychodynamic-programmes-for-personality-disorders
#4
Marco Chiesa, Antonella Cirasola, Peter Fonagy
Although the fulcrum of service provision for personality disorder (PD) has shifted from hospital-based to psychodynamically- and cognitively-oriented outpatient programmes, very few studies have attempted to compare specialist moderate intensity outpatient programmes with specialist high-intensity residential models, or to explore whether a period of inpatient treatment may be necessary to improve outcome and prognosis. In this article, we prospectively compare changes over a 4-year period in 3 groups of patients with personality disorders (N = 162) treated in a specialist community-based (CBP, N = 30), a step-down (RT-CBP, N = 87), and a specialist residential programme (RT, N = 45) in psychiatric distress, deliberate self-injury, and suicide attempt using multilevel modelling and multivariate logistic regression analyses...
July 26, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28748484/assessing-for-suicidal-behavior-in-youth-using-the-achenbach-system-of-empirically-based-assessment
#5
Anna R Van Meter, Guillermo Perez Algorta, Eric A Youngstrom, Yana Lechtman, Jen K Youngstrom, Norah C Feeny, Robert L Findling
This study investigated the clinical utility of the Achenbach System of Empirically Based Assessment (ASEBA) for identifying youth at risk for suicide. Specifically, we investigated how well the Total Problems scores and the sum of two suicide-related items (#18 "Deliberately harms self or attempts suicide" and #91 "Talks about killing self") were able to distinguish youth with a history of suicidal behavior. Youth (N = 1117) aged 5-18 were recruited for two studies of mental illness. History of suicidal behavior was assessed by semi-structured interviews (K-SADS) with youth and caregivers...
July 26, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28748410/cytotoxic-effect-of-co-expression-of-human-hepatitis-a-virus-3c-protease-and-bifunctional-suicide-protein-fcu1-genes-in-a-bicistronic-vector
#6
Alexey Komissarov, Ilya Demidyuk, Dina Safina, Marina Roschina, Andrey Shubin, Nataliya Lunina, Maria Karaseva, Sergey Kostrov
Recent reports on various cancer models demonstrate a great potential of cytosine deaminase/5-fluorocytosine suicide system in cancer therapy. However, this approach has limited success and its application to patients has not reached the desirable clinical significance. Accordingly, the improvement of this suicide system is an actively developing trend in gene therapy. The purpose of this study was to explore the cytotoxic effect observed after co-expression of hepatitis A virus 3C protease (3C) and yeast cytosine deaminase/uracil phosphoribosyltransferase fusion protein (FCU1) in a bicistronic vector...
July 26, 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/28748212/genetically-engineered-multilineage-differentiating-stress-enduring-cells-as-cellular-vehicles-against-malignant-gliomas
#7
Tomohiro Yamasaki, Shohei Wakao, Hiroshi Kawaji, Shinichiro Koizumi, Tetsuro Sameshima, Mari Dezawa, Hiroki Namba
Malignant glioma, the most common malignant brain tumor in adults, is difficult to treat due to its aggressive invasive nature. Enzyme/prodrug suicide gene therapy based on the herpes simplex virus thymidine kinase (HSVtk)/ganciclovir (GCV) system is an efficient strategy for treating malignant gliomas. In the present study, we evaluated treatment with multilineage-differentiating stress-enduring (Muse) cells, which are endogenous non-tumorigenic pluripotent-like stem cells that are easily collectable from the bone marrow as SSEA-3(+) cells, as carriers of the HSVtk gene...
September 15, 2017: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/28747929/relationship-between-bullying-and-suicidal-behaviour-in-youth-presenting-to-the-emergency-department
#8
Nazanin Alavi, Taras Reshetukha, Eric Prost, Kristen Antoniak, Charmy Patel, Saad Sajid, Dianne Groll
OBJECTIVE: Increasing numbers of adolescents are visiting emergency departments with suicidal ideation. This study examines the relationship between bullying and suicidal ideation in emergency department settings. METHOD: A chart review was conducted for all patients under 18 years of age presenting with a mental health complaint to the emergency departments at Kingston General or Hotel Dieu Hospitals in Kingston, Canada, between January 2011 and January 2015. Factors such as age, gender, history of abuse, history of bullying, type and time of bullying, and diagnoses were documented...
July 2017: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28747112/book-review-the-ethics-of-suicide-the-ethics-of-suicide-battin-margaret-pabst-oxford-oxford-university-press-oxford-2015-isbn-978-0-19-513599-2
#9
Saxby Pridmore
No abstract text is available yet for this article.
August 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28747108/an-alternative-aide-m%C3%A3-moire-to-assist-in-the-clinical-assessment-of-suicidal-patients-comment-on-alyami-et-al
#10
Matthew Large, Hannah Myles, Christopher James Ryan
No abstract text is available yet for this article.
August 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28747094/a-comparison-of-socioeconomic-status-and-mental-health-among-inner-city-aboriginal-and-non-aboriginal-women
#11
Kevin Hamdullahpur, Kahá Wi J Jacobs, Kathryn J Gill
Aboriginal women in urban areas have been reported to experience high rates of poverty, homelessness, interpersonal violence, and health problems. However, there are few prior ethnocultural comparisons of urban women from similar socioeconomic backgrounds. The current study explored the mental and physical health of Aboriginal and non-Aboriginal women accessing social services agencies and shelters. Half of the sample (n=172) was Aboriginal (48.3%). The lifetime rate of physical abuse was significantly higher in Aboriginal women, and they were more likely to have been victims of violence or crime in the past year (A=50...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28746711/suicidal-behaviors-within-army-units-contagion-and-implications-for-public-health-interventions
#12
Charles W Hoge, Christopher G Ivany, Amy B Adler
No abstract text is available yet for this article.
July 26, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28746705/risk-of-suicide-attempt-among-soldiers-in-army-units-with-a-history-of-suicide-attempts
#13
Robert J Ursano, Ronald C Kessler, James A Naifeh, Holly Herberman Mash, Carol S Fullerton, Paul D Bliese, Alan M Zaslavsky, Tsz Hin Hinz Ng, Pablo A Aliaga, Gary H Wynn, Hieu M Dinh, James E McCarroll, Nancy A Sampson, Tzu-Cheg Kao, Michael Schoenbaum, Steven G Heeringa, Murray B Stein
Importance: Mental health of soldiers is adversely affected by the death and injury of other unit members, but whether risk of suicide attempt is influenced by previous suicide attempts in a soldier's unit is unknown. Objective: To examine whether a soldier's risk of suicide attempt is influenced by previous suicide attempts in that soldier's unit. Design, Setting, and Participants: Using administrative data from the Army Study to Assess Risk and Resilience in Servicemembers (STARRS), this study identified person-month records for all active-duty, regular US Army, enlisted soldiers who attempted suicide from January 1, 2004, through December 31, 2009 (n = 9650), and an equal-probability sample of control person-months (n = 153 528)...
July 26, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28746699/association-of-risk-of-suicide-attempts-with-methylphenidate-treatment
#14
Kenneth K C Man, David Coghill, Esther W Chan, Wallis C Y Lau, Chris Hollis, Elizabeth Liddle, Tobias Banaschewski, Suzanne McCarthy, Antje Neubert, Kapil Sayal, Patrick Ip, Martijn J Schuemie, Miriam C J M Sturkenboom, Edmund Sonuga-Barke, Jan Buitelaar, Sara Carucci, Alessandro Zuddas, Hanna Kovshoff, Peter Garas, Peter Nagy, Sarah K Inglis, Kerstin Konrad, Alexander Häge, Eric Rosenthal, Ian C K Wong
Importance: Patients with attention-deficit/hyperactivity disorder (ADHD) are at an increased risk of attempting suicide. Stimulants, such as methylphenidate hydrochloride, are the most common treatment for ADHD, but the association between their therapeutic use and suicide is unclear. Objective: To investigate the association between methylphenidate and the risk of suicide attempts. Design, Setting, and Participants: A population-based, electronic medical records database from the Hong Kong Clinical Data Analysis & Reporting System was used to identify 25 629 individuals aged 6 to 25 years who were treated with methylphenidate between January 1, 2001, and December 31, 2015...
July 26, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28745682/-risk-factors-and-prevention-of-recurrent-dynamics-of-depression
#15
D Yu Veltishchev, O B Kovalevskaya, O F Seravina
The existing literature in the field demonstrates that in the majority of cases depressive disorder has a recurrent course that resulted in negative consequences: an increase in a number of chronic and marked episodes, a higher risk of suicide and stable cognitive deficit. An analysis of predictors promoting the formation of recurrent depressive disorder allows an identification of a constellation of biological, psychological, therapeutic, social factors which should be taken into account in the choice of methods of prevention of the next episode of depression...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28745388/suicidal-ideation-and-self-injurious-behavior-in-adolescents-with-eating-disorders
#16
Olalla Varela-Besteiro, Eduardo Serrano-Troncoso, Virginia Rodríguez-Vicente, Marta Curet-Santisteban, Gemma Conangla-Roselló, Raquel Cecilia-Costa, Marta Carulla-Roig, Josep L Matalí-Costa, Montserrat Dolz-Abadia
INTRODUCTION: The presence of suicidal thoughts and self-injurious behaviors in patients with eating disorders (ED) is well-known; however, this association is currently not defined empirically. The aim of the study is to determine the prevalence of suicidal ideation and self-harm in adolescents with eating disorders. A second objective is to study the association between self-injurious behavior and suicidal ideation, severity of eating disorder symptoms and symptoms of depression and anxiety, motivation to change and perfectionism...
July 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/28744098/spotlight-on-brodalumab-in-the-treatment-of-moderate-to-severe-plaque-psoriasis-design-development-and-potential-place-in-therapy
#17
REVIEW
Michael Roman, Melvin W Chiu
Brodalumab is a novel fully human immunoglobulin G2 monoclonal antibody that antagonizes the interleukin (IL)-17 pathway by binding with high affinity to human IL-17RA. The role of IL-17A in the pathogenesis of psoriasis, as well as the remarkable effectiveness of IL-17 inhibitors in the treatment of moderate-to-severe plaque psoriasis, is well established. The mechanism of action of brodalumab is unique in that it inhibits the IL-17 receptor compared to the two other currently FDA-approved IL-17 inhibitors, secukinumab and ixekizumab, which inhibit the IL-17A molecule itself...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28743945/lithium-sensitive-orai1-expression-store-operated-ca-2-entry-and-suicidal-death-of-neurons-in-chorea-acanthocytosis
#18
Lisann Pelzl, Stefan Hauser, Bhaeldin Elsir, Basma Sukkar, Itishri Sahu, Yogesh Singh, Philip Höflinger, Rosi Bissinger, Mohamed Jemaà, Christos Stournaras, Ludger Schöls, Florian Lang
Chorea-Acanthocytosis (ChAc), a neurodegenerative disorder, results from loss-of-function-mutations of chorein-encoding gene VPS13A. In tumour cells chorein up-regulates ORAI1, a Ca(2+)-channel accomplishing store operated Ca(2+)-entry (SOCE) upon stimulation by STIM1. Furthermore SOCE could be up-regulated by lithium. The present study explored whether SOCE impacts on neuron apoptosis. Cortical neurons were differentiated from induced pluripotent stem cells generated from fibroblasts of ChAc patients and healthy volunteers...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743492/5-bromoindirubin-3-o-oxiran-2-ylmethyl-oxime-a-long-acting-anticancer-agent-and-a-suicide-inhibitor-for-epoxide-hydrolase
#19
Yoshimi Ichimaru, Takeshi Fujii, Hiroaki Saito, Makoto Sano, Taketo Uchiyama, Shinichi Miyairi
Indirubin 3'-oxime (Indox (1b)) suppresses cancer cell growth (IC50: 15μM towards HepG2 cells) and inhibits cell cycle-related kinases such as cyclin-dependent kinases and glycogen synthase kinase-3β. We have previously reported that the conjugation of 1b with oxirane, a protein-reactive component, enhanced the cytotoxic activity of Indox as determined from the IC50 value (1.7μM) of indirubin 3'-(O-oxiran-2-ylmethyl)oxime (Epox/Ind (1c)). Here we prepared Epox/Ind derivatives with one or two halogen atoms or a methoxy group on the aromatic ring(s) of an Indox moiety and studied the structure-activity relationships of the substituent(s)...
July 8, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28743477/psychological-scales-as-predictors-of-emergency-department-hospitalizations-in-suicide-attempters
#20
Dae Woong Kim, Ki Young Jeong, Kyung Su Kim
BACKGROUND: The purpose of this study was to evaluate the psychological scales reflecting lethality and intent as predictors of suicide attempter's hospitalization. METHODS: Data of suicide attempters aged over 15years, who visited the ED from January 2013 to June 2016, were retrospectively collected and they were divided into the hospitalization and discharge groups. We evaluated the Risk-Rescue Rating Scale (RRRS) and Self-Inflicted Injury Severity Form (SIISF) for lethality and Suicide Intent Scale (SIS) for intent, respectively...
July 13, 2017: American Journal of Emergency Medicine
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