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Feline obesity

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https://www.readbyqxmd.com/read/29140289/cats-and-carbohydrates-the-carnivore-fantasy
#1
REVIEW
Adronie Verbrugghe, Myriam Hesta
The domestic cat's wild ancestors are obligate carnivores that consume prey containing only minimal amounts of carbohydrates. Evolutionary events adapted the cat's metabolism and physiology to this diet strictly composed of animal tissues and led to unique digestive and metabolic peculiarities of carbohydrate metabolism. The domestic cat still closely resembles its wild ancestor. Although the carnivore connection of domestic cats is well recognised, little is known about the precise nutrient profile to which the digestive physiology and metabolism of the cat have adapted throughout evolution...
November 15, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/28958218/effects-of-obesity-energy-restriction-and-neutering-on-the-faecal-microbiota-of-cats
#2
Manuela M Fischer, Alexandre M Kessler, Dorothy A Kieffer, Trina A Knotts, Kyoungmi Kim, Alfreda Wei, Jon J Ramsey, Andrea J Fascetti
Surveys report that 25-57 % of cats are overweight or obese. The most evinced cause is neutering. Weight loss often fails; thus, new strategies are needed. Obesity has been associated with altered gut bacterial populations and increases in microbial dietary energy extraction, body weight and adiposity. This study aimed to determine whether alterations in intestinal bacteria were associated with obesity, energy restriction and neutering by characterising faecal microbiota using 16S rRNA gene sequencing in eight lean intact, eight lean neutered and eight obese neutered cats before and after 6 weeks of energy restriction...
October 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28916548/do-comorbidities-play-a-role-in-hand-osteoarthritis-disease-burden-data-from-the-hand-osteoarthritis-in-secondary-care-cohort
#3
Wendy Damman, Rani Liu, Féline P B Kroon, Monique Reijnierse, Tom W J Huizinga, Frits R Rosendaal, Margreet Kloppenburg
OBJECTIVE: Because the association and its clinical relevance between comorbidities and primary hand osteoarthritis (OA) disease burden is unclear, we studied this in patients with hand OA from our Hand OSTeoArthritis in Secondary care (HOSTAS) cohort. METHODS: Cross-sectional data from the HOSTAS study were used, including consecutive patients with primary hand OA. Nineteen comorbidities were assessed: 18 self-reported (modified Charlson index and osteoporosis) and obesity (body mass index ≥ 30 kg/m(2))...
November 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28716190/risk-factors-for-underweight-and-overweight-in-cats-in-metropolitan-sydney-australia
#4
Kendy T Teng, Paul D McGreevy, Jenny-Ann L M L Toribio, David Raubenheimer, Kim Kendall, Navneet K Dhand
Obesity is regarded as one of the most significant welfare issues in companion animals. Some risk factors affecting body condition in cats have been determined, but many remain controversial. The current study aimed to investigate the risk factors for overweight and underweight in cats in metropolitan Sydney. Electronic patient records for 11 years (2005-2015) were acquired from a feline primary practice in metropolitan Sydney. The 9-point body condition score (BCS) evaluation in each visit was classified into three groups: underweight (1-3), ideal-weight (4-6) and overweight (7-9)...
September 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28630694/physical-activity-level-of-female-and-male-adult-cats-before-and-after-running-wheel-habituation
#5
Katelyn B Detweiler, Samona Rawal, Kelly S Swanson, Maria R C de Godoy
The objective of the present study was to evaluate whether access to a running wheel increases voluntary physical activity in adult female and male domestic cats. Eight neutered domestic shorthair male cats (mean age 8·6 (sd 0·05) years) and eleven intact domestic shorthair female cats (mean age 3·3 (sd 0·14) years) were group housed for 22 h daily and individually housed during the feeding period. Voluntary physical activity was measured using accelerometers. Experimental design consisted of 1 week of baseline physical activity measurement, followed by 3 weeks of wheel habituation, and 1 week of physical activity measurement post-wheel habituation...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28622790/early-life-risk-factors-identified-for-owner-reported-feline-overweight-and-obesity-at-around-two-years-of-age
#6
E C Rowe, W J Browne, R A Casey, T J Gruffydd-Jones, J K Murray
Obesity is considered the second most common health problem in pet cats in developed countries. This study used prospective data from a longitudinal study of pet cats ('C.L.A.W.S.', www.bristol.ac.uk/vetscience/claws) to identify early-life risk factors for feline overweight/obesity occurring at around two years of age. Data were collected via five owner-completed questionnaires (for cats aged two-six months, six months, 12 months, 18 months and two years respectively) completed between May 2011 and April 2015...
August 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28413044/expression-profiling-feline-peripheral-blood-monocytes-identifies-a-transcriptional-signature-associated-with-type-two-diabetes-mellitus
#7
Caroline A O'Leary, Mamdouh Sedhom, Mia Reeve-Johnson, John Mallyon, Katharine M Irvine
Diabetes mellitus is a common disease of cats and is similar to type 2 diabetes (T2D) in humans, especially with respect to the role of obesity-induced insulin resistance, glucose toxicity, decreased number of pancreatic β-cells and pancreatic amyloid deposition. Cats have thus been proposed as a valuable translational model of T2D. In humans, inflammation associated with adipose tissue is believed to be central to T2D development, and peripheral blood monocytes (PBM) are important in the inflammatory cascade which leads to insulin resistance and β-cell failure...
April 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28376869/differential-circulating-concentrations-of-adipokines-glucagon-and-adropin-in-a-clinical-population-of-lean-overweight-and-diabetic-cats
#8
Rizaldy C Zapata, Melissa D Meachem, Natalia Cavalca Cardoso, Susan O Mehain, Chantal J McMillan, Elisabeth R Snead, Prasanth K Chelikani
BACKGROUND: Dyslipidemia, dysregulated adipokine secretion and alteration in glucagon and adropin concentrations are important obesity-related factors in the pathophysiology of human Type 2 diabetes; however, their roles in the pathophysiology of feline diabetes mellitus are relatively unknown. Here, we determined the concentrations of circulating leptin, adiponectin, pro-inflammatory cytokines, glucagon, adropin, triglycerides, and cholesterol, in non-diabetic lean and overweight cats and newly diagnosed diabetic cats...
April 4, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28261588/comparison-of-visceral-fat-accumulation-and-metabolome-markers-among-cats-of-varying-bcs-and-novel-classification-of-feline-obesity-and-metabolic-syndrome
#9
Yuki Okada, Motoo Kobayashi, Masaki Sawamura, Toshiro Arai
As in humans, obesity and its associated diseases represent the most significant threat to the health of veterinary populations. Previous human studies have provided insights into the risk factors of obesity, complex pathogenesis of obesity-associated diseases, and their life-threatening consequences. In humans, the "metabolic syndrome" represents a cluster of metabolic risk factors associated with the development of cardiovascular disease. Risk factors for metabolic syndrome, such as diabetes, obesity, high blood pressure, and its complications increase health-care utilization and medical expenses...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28077692/reference-curves-for-the-australian-canadian-hand-osteoarthritis-index-in-the-middle-aged-dutch-population
#10
Féline P B Kroon, Sofia Ramiro, Patrick Royston, Saskia Le Cessie, Frits R Rosendaal, Margreet Kloppenburg
Objective.: The aim was to establish reference curves of the Australian/Canadian Hand Osteoarthritis Index (AUSCAN), a widely used questionnaire assessing hand complaints. Methods.: Analyses were performed in a population-based sample, The Netherlands Epidemiology of Obesity study (n = 6671, aged 45-65 years). Factors associated with AUSCAN scores were analysed with ordered logistic regression, because AUSCAN data were zero inflated, dividing AUSCAN into three categories (0 vs 1-5 vs >5)...
May 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/27919269/comparison-of-voluntary-food-intake-and-palatability-of-commercial-weight-loss-diets-in-healthy-dogs-and-cats
#11
Marie Anne Hours, Emmanuelle Sagols, Ariane Junien-Castagna, Alexandre Feugier, Delphine Moniot, Ingrid Daniel, Vincent Biourge, Serisier Samuel, Yann Queau, Alexander J German
BACKGROUND: Obesity in dogs and cats is usually managed by dietary energy restriction using a purpose-formulated weight loss diet, but signs of hunger and begging commonly occur causing poor owner compliance. Altering diet characteristics so as to reduce voluntary food intake (VFI) can improve the likelihood of success, although this should not be at the expense of palatability. The aim of the current study was to compare the VFI and palatibility of novel commercially available canine and feline weight loss diets...
December 5, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27565231/diagnosis-of-prediabetes-in-cats-glucose-concentration-cut-points-for-impaired-fasting-glucose-and-impaired-glucose-tolerance
#12
M K Reeve-Johnson, J S Rand, D Vankan, S T Anderson, R Marshall, J M Morton
Diabetes is typically diagnosed in cats once clinical signs are evident. Diagnostic criteria for prediabetes in cats have not been defined. The objective of the study was to establish methodology and cut points for fasting and 2-h blood glucose concentrations in healthy client-owned senior cats (≥8 yr) using ear/paw samples and a portable glucose meter calibrated for feline blood. Of the 78 cats, 27 were ideal (body condition score [BCS] 4 or 5 of 9), 31 overweight (BCS 6 or 7), and 20 obese (BCS 8 or 9); 19 were Burmese and 59 non-Burmese...
October 2016: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27368578/current-topics-in-canine-and-feline-obesity
#13
REVIEW
Beth Hamper
The domestication and urbanization of dogs and cats has dramatically altered their environment and behavior. Human and pet obesity is a global concern, particularly in developed countries. An increased incidence of chronic disease is associated with obesity secondary to low-grade systemic inflammation. This article reviews current research into the genetic, dietary, and physiologic factors associated with obesity, along with use of "omics" technology to better understand and characterize this disease.
September 2016: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/27348888/effectiveness-of-feline-body-mass-index-fbmi-as-new-diagnostic-tool-for-obesity
#14
Koh Kawasumi, Eiji Iwazaki, Yuki Okada, Toshiro Arai
Feline body mass index (fBMI), BW/PCL, length from top of patella to end of calcaneus, was developed as a new diagnostic tool for obesity in cats. To evaluate the effectiveness of fBMI for obese cats in short-term, 6 cats were induced weight gain by over-feeding with high fat diet and then they were induced weight reduction by restrict-feeding with low fat diet to measure changes in fBMI and plasma metabolite concentrations and enzyme activities. BCS 3 is correlated with fBMI 24.6-32.0, BCS 4 is correlated with fBMI 33...
February 2016: Japanese Journal of Veterinary Research
https://www.readbyqxmd.com/read/27289253/obesity-exercise-and-orthopedic-disease
#15
REVIEW
Christopher W Frye, Justin W Shmalberg, Joseph J Wakshlag
Osteoarthritis is common among aging canine and feline patients. The incidence and severity of clinical lameness are closely correlated to body condition in overweight and obese patients. Excessive adiposity may result in incongruous and excessive mechanical loading that worsens clinical signs in affected patients. Data suggest a potential link between adipokines, obesity-related inflammation, and a worsening of the underlying pathology. Similarly, abnormal physical stress and generalized systemic inflammation propagated by obesity contribute to neurologic signs associated with intervertebral disc disease...
September 2016: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/26609567/circulating-concentrations-of-glucagon-like-peptide-1-glucose-dependent-insulinotropic-peptide-peptide-yy-and-insulin-in-client-owned-lean-overweight-and-diabetic-cats
#16
C J McMillan, R C Zapata, P K Chelikani, E C R Snead, K Cosford
Our objectives were to measure plasma concentrations of glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), and peptide YY (PYY) in client-owned newly diagnosed diabetic cats and nondiabetic lean or overweight cats and to determine whether circulating concentrations of these hormones differed between study groups and if they increased postprandially as seen in other species. A total of 31 cats were recruited and placed into 1 of 3 study groups: lean (body condition score 4-5 on a scale of 1-9; n = 10), overweight (body condition score 6-8; n = 11), or diabetic (n = 10)...
January 2016: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/26452635/overweight-and-the-feline-gut-microbiome-a-pilot-study
#17
I N Kieler, L Mølbak, L L Hansen, M L Hermann-Bank, C R Bjornvad
Compared with lean humans, the gut microbiota is altered in the obese. Whether these changes are due to an obesogenic diet, and whether the microbiota contributes to adiposity is currently discussed. In the cat population, where obesity is also prevalent, gut microbiome changes associated with obesity have not been studied. Consequently, the aim of this study was to compare the gut microbiota of lean cats, with that of overweight and obese cats. Seventy-seven rescue-shelter cats housed for ≥3 consecutive days were included in the study...
June 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/26452529/characterization-of-key-genes-of-the-renin-angiotensin-system-in-mature-feline-adipocytes-and-during-in%C3%A2-vitro-adipogenesis
#18
J Riedel, B Badewien-Rentzsch, B Kohn, L Hoeke, R Einspanier
Obesity is a growing health problem in humans as well as companion animals. In the development and progression of obesity-associated diseases, the members of the renin-angiotensin system (RAS) are proposed to be involved. Particularly, the prevalence of type 2 diabetes mellitus in cats has increased enormously which is often been linked to obesity as well as to RAS. So far, reports about the expression of a local RAS in cat adipocytes are missing. Therefore, we investigated the mRNA expression of various RAS genes as well as the adipocyte marker genes adiponectin, leptin and PPAR-γ in feline adipocytes using quantitative PCR...
December 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/26268360/changes-in-fatty-acid-composition-in-tissue-and-serum-of-obese-cats-fed-a-high-fat-diet
#19
Megumi Fujiwara, Nobuko Mori, Touko Sato, Hiroyuki Tazaki, Shingo Ishikawa, Ichiro Yamamoto, Toshiro Arai
BACKGROUND: Obesity and overweight have been frequently observed in dogs and cats in recent years as in humans. The compositions of fatty acids (FAs) in the accumulated lipids in tissues of obese animals may have important roles in the process and mechanisms related to the onset of metabolic disorders. The purpose of this study was to evaluate the effects of a high fat (HF) diet, which contained a higher proportion of saturated FAs, on FA metabolism and distribution in obese cats. Cats (N = 12) were divided into control diet group (crude fat; 16...
2015: BMC Veterinary Research
https://www.readbyqxmd.com/read/26265631/risk-factors-identified-for-owner-reported-feline-obesity-at-around-one-year-of-age-dry-diet-and-indoor-lifestyle
#20
Elizabeth Rowe, William Browne, Rachel Casey, Tim Gruffydd-Jones, Jane Murray
Obesity is considered the second most common health problem in pet cats in developed countries. Previous studies investigating risk factors for feline obesity have been cross-sectional, where reverse causality cannot be ruled out. This study is the first to use prospective data from a large scale longitudinal study of pet cats ('Bristol Cats') to identify early-life risk factors for feline overweight/obesity at around one year of age. Data analysed were collected via three owner-completed questionnaires (for cats aged 2-4 months, 6...
October 1, 2015: Preventive Veterinary Medicine
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