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https://www.readbyqxmd.com/read/28161356/a-retrospective-cross-sectional-quantitative-molecular-approach-in-biological-samples-from-patients-with-syphilis
#1
Miguel Pinto, Minia Antelo, Rita Ferreira, Jacinta Azevedo, Irene Santo, Maria José Borrego, João Paulo Gomes
Syphilis is the sexually transmitted disease caused by Treponema pallidum, a pathogen highly adapted to the human host. As a multistage disease, syphilis presents distinct clinical manifestations that pose different implications for diagnosis. Nevertheless, the inherent factors leading to diverse disease progressions are still unknown. We aimed to assess the association between treponemal loads and dissimilar disease outcomes, to better understand syphilis. We retrospectively analyzed 309 DNA samples distinct anatomic sites associated with particular syphilis manifestations...
February 2, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28128088/gestational-pityriasis-rosea-suggestions-for-approaching-affected-pregnant-women
#2
Alexandra Monastirli, Efstathia Pasmatzi, George Badavanis, Dionysios Tsambaos
Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7 (1). It predominantly affects individuals of both sexes in their second or third decade of life and is clinically characterized by the occurrence of an initial erythematosquamous plaque followed by the appearance of disseminated similar but smaller lesions one or two weeks later. Several patients develop systemic symptoms such as nausea, anorexia, malaise, headache, fever, arthralgia, and lymphadenopathy that may precede or accompany the eruption; the latter follows the cleavage lines of the trunk creating the configuration of a Christmas tree and spontaneously resolves within 4 to 8 weeks...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28058468/-nonviral-sexually-transmitted-infections-epidemiology-clinical-manifestations-diagnostic-workup-therapy-part%C3%A2-3-treponemes-gardnerella-and-trichomonads
#3
REVIEW
P Nenoff, A Manos, I Ehrhard, C Krüger, U Paasch, P Helmbold, W Handrick
In Germany, the reported syphilis prevalence has increased continuously since 2010, with a total of 6834 syphilis cases being reported in 2015. The largest increase of reported syphilis occurred in men who have sex with men (MSM). The antibiotic agent of choice for treatment of syphilis is still penicillin. There are no penicillin-resistant Treponema pallidum strains. Alternatives are ceftriaxone and doxycycline. In Germany, azithromycin is not approved for treatment of syphilis; however, therapy failures are increasingly reported...
January 5, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28056870/anti-n-methyl-d-aspartate-receptor-nmdar-antibody-encephalitis-presents-in-atypical-types-and-coexists-with-neuromyelitis-optica-spectrum-disorder-or-neurosyphilis
#4
Kaiyu Qin, Wenqing Wu, Yuming Huang, Dongmei Xu, Lei Zhang, Bowen Zheng, Meijuan Jiang, Cheng Kou, Junhua Gao, Wurong Li, Jinglin Zhang, Sumei Wang, Yanfei Luan, Chaoling Yan, Dan Xu, Xinmei Zheng
BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a clinically heterogeneous disorder characterized by epileptic seizures, psychosis, dyskinesia, consciousness impairments, and autonomic instability. Symptoms are always various. Sometimes it presents in milder or incomplete forms. We report 4 cases of anti-NMDAR encephalitis with incomplete forms, 3 cases of which were accompanied by neuromyelitis optica spectrum disorder or neurosyphilis respectively. CASE PRESENTATION: A 33-year-old man presented with dysarthria, movement disorder and occasional seizures...
January 5, 2017: BMC Neurology
https://www.readbyqxmd.com/read/27995270/schnelltest-diagnostik-sexuell-%C3%A3-bertragbarer-infektionen-in-niedrigschwelligen-einrichtungen-gemeinsame-stellungnahme-des-rki-pei-und-der-dstig
#5
Thomas Meyer, Christian G Schüttler, Eberhard Straube, R Stefan Roß, Martin Stürmer, Klaus Jansen, Susanne Buder, Sigrid Nick, Hans-Jochen Hagedorn, Viviane Bremer, Norbert H Brockmeyer
On February 5th, 2016 an expert meeting on rapid diagnostic tests (RDT) for sexually transmitted infections (STI) was held in Berlin at the Robert-Koch-Institute. The aim of the conference was to update a former evaluation of RDTs for diagnosis of HIV, HBV, HCV, T. pallidum, C. trachomatis and N. gonorrhoeae in low-threshold counseling services for STI that had been published after the previous meeting in 2012. According to the strategy to control HIV, hepatitis B and C and other STI, recently adopted by the German Government, there is a lack of test capabilities and a demand for more testing services as well as improved access to testing...
December 19, 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27622435/cerebral-microcalcifications-in-a-newborn-with-congenital-tuberculosis
#6
Yolanda Cifuentes, Martha Isabel Murcia, Jorge Piar, Patricia Pardo
Tuberculosis is a serious public health problem worldwide. In 2012, the World Health Organization estimated 8.6 million new cases and 1.3 million deaths due to the disease. In 2011, the incidence in Colombia was 24 cases per 100,000 inhabitants. There is little information about tuberculosis in pregnant women, and congenital infection is considered a rare disease that is difficult to diagnose, leads to high mortality, and may be confused with tuberculosis acquired after birth. In addition, it has been associated with HIV infection in mothers and infants...
March 3, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27585981/clinical-and-biological-characteristics-of-40-patients-with-neurosyphilis-and-evaluation-of-treponema-pallidum-nested-polymerase-chain-reaction-in-cerebrospinal-fluid-samples
#7
Clélia Vanhaecke, Philippe Grange, Nadjet Benhaddou, Philippe Blanche, Dominique Salmon, Perrine Parize, Olivier Lortholary, Eric Caumes, Isabelle Pelloux, Olivier Epaulard, Jérôme Guinard, Nicolas Dupin
BACKGROUND:  Syphilis remains a significant public health problem. We conducted a prospective study to define more precisely the clinical and biological characteristics of patients with neurosyphilis (NS), and we assessed the diagnostic value of nested polymerase chain reaction (PCR) testing for Treponema pallidum in cerebrospinal fluid (CSF) samples. METHODS:  From 2001 to 2013, we included 40 patients (90% men; 45% infected with human immunodeficiency virus) with NS, defined as syphilis with neurological and/or ophthalmological symptoms and CSF abnormalities...
November 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27524923/a-case-report-of-epstein-barr-virus-associated-retinal-vasculitis-successful-treatment-using-only-acyclovir-therapy
#8
Narumon Keorochana
The purpose of this study was to describe a presumed case of Epstein-Barr virus (EBV)-associated retinal vasculitis in a 42-year-old female with sudden unilateral vision loss and successful treatment with acyclovir therapy. Diagnostic vitreous biopsy of the right eye was performed to test for EBV and other known infectious causes of retinitis and evaluate vitreous cells and serological testing. Vitreous polymerase chain reaction viral DNA testing result was positive for EBV but negative for herpes simplex virus, varicella-zoster virus, and cytomegalovirus...
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/27467164/high-resistance-to-azithromycin-in-clinical-samples-from-patients-with-sexually-transmitted-diseases-in-guangxi-zhuang-autonomous-region-china
#9
Bangyong Zhu, Jin Bu, Wei Li, Jie Zhang, Geng Huang, Juan Cao, Zhongshu Tang, Quan Gan, Pingjiang Wei
Azithromycin is used as an alternative medicine in patients with syphilis who are intolerant to penicillin. Nevertheless, the report of treatment failure of azithromycin for patients with syphilis has raised concerns in China in the past years. In this study, 178 patients with early syphilis, who were treated in sexually transmitted infections clinics in four cities in Guangxi Zhuang Autonomous Region were enrolled to investigate the regional prevalence of Treponema pallidum strain resistant to azithromycin...
2016: PloS One
https://www.readbyqxmd.com/read/27266230/prevalence-of-sexually-transmitted-infection-in-teenage-pregnancy-in-rajavithi-hospital-thailand
#10
Suvanna Asavapiriyanont, Udom Chaovarindr, Surasak Kaoien, Uraiwan Chotigeat, Ekachai Kovavisarach
BACKGROUND: Behavioral and social changes in the modern era have triggered an increase in the incidence of early sexual contact and teenage pregnancy. Since there is no routine Gonococcal & Chlamydial (GC & CT) screening in teens in antenatal clinics in Thailand, the present study was performed to find the prevalence of STI, especially Chlamydial infection, in teenage pregnancy. OBJECTIVE: To evaluate the prevalence of sexually transmitted infections (STIs), especially Chlamydial infection (CT), in teenage pregnancy and its related factors...
February 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27164464/chlamydia-trachomatis-and-neisseria-gonorrhoeae-in-hiv-infected-pregnant-women-and-adverse-infant-outcomes
#11
Kristina Adachi, Jeffrey D Klausner, Jiahong Xu, Bonnie Ank, Claire C Bristow, Mariza G Morgado, D Heather Watts, Fred Weir, David Persing, Lynne M Mofenson, Valdilea G Veloso, Jose Henrique Pilotto, Esau Joao, Glenda Gray, Gerhard Theron, Breno Santos, Rosana Fonseca, Regis Kreitchmann, Jorge Pinto, Marisa M Mussi-Pinhata, Mariana Ceriotto, Daisy Maria Machado, Yvonne J Bryson, Beatriz Grinsztejn, Francisco I Bastos, George Siberry, Karin Nielsen-Saines
BACKGROUND: Sexually transmitted infections (STIs) in pregnancy such as Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) may lead to adverse infant outcomes. METHODS: Individual urine specimens from HIV-infected pregnant women diagnosed with HIV during labor were collected at the time of infant birth and tested by polymerase chain reaction for CT and NG. Infant HIV infection was determined at 3 months with morbidity/mortality assessed through 6 months. RESULTS: Of 1373 maternal urine samples, 277 (20...
August 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27100768/molecular-subtyping-and-surveillance-of-resistance-genes-in-treponema-pallidum-dna-from-patients-with-secondary-and-latent-syphilis-in-hunan-china
#12
Yongjian Xiao, Shuangquan Liu, Zhuoran Liu, Yafeng Xie, Chuanhao Jiang, Man Xu, Feijun Zhao, TieBing Zeng, Jian Yu, Yimou Wu
BACKGROUND: Over the past decade, the incidence of syphilis and widespread macrolide resistance in its etiological agent, Treponema pallidum subsp. pallidum, have become a major health concern across countries, including China. Regional trends in subtypes and antibiotic resistance can be monitored effectively by molecular surveillance programs. In this study, whole blood samples were used to assess circulating T. pallidum strains collected from various regions of Hunan, China, between 2013 and 2015...
May 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/26963688/notes-from-the-field-lymphocytic-choriomeningitis-virus-meningoencephalitis-from-a-household-rodent-infestation-minnesota-2015
#13
Pamela Talley, Stacy Holzbauer, Kirk Smith, William Pomputius
On April 20, 2015, a female aged 15 years sought care at her pediatrician's office after 5 days of fever, myalgia, left parietal headache, and photophobia. A rapid influenza assay was negative, and erythrocyte sedimentation rate and total white blood cell count were normal. She improved with symptomatic care at home, but returned to her pediatrician's office on April 28, reporting recurrence of her headache and photophobia and new onset of a stiff neck. She was admitted to the hospital, where she was febrile to 102...
March 11, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/26892231/detection-of-treponema-pallidum-sp-pallidum-dna-in-cerebrospinal-fluid-csf-by-two-pcr-techniques
#14
Rita Castro, Maria João Águas, Teresa Batista, Carlos Araújo, Kamal Mansinho, Filomena da Luz Martins Pereira
BACKGROUND: Laboratory diagnosis of neurosyphilis is complicated especially when it is asymptomatic, no single laboratory test result being appropriate to diagnose central nervous system infectivity caused by Treponema pallidum. Our objective was to evaluate two polymerase chain reaction (PCR) techniques for the detection of T. pallidum DNA in the cerebrospinal fluid (CSF) of patients with syphilis. METHODS: One hundred twenty-four CSF samples from patients with reactive blood tests for syphilis were obtained...
September 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/26880101/sexually-transmitted-infections-and-use-of-contraceptives-in-women-living-with-hiv-in-denmark-the-shade-cohort
#15
MULTICENTER STUDY
Kristina Thorsteinsson, Steen Ladelund, Merete Storgaard, Frederikke Falkencrone Rønsholt, Isik Somuncu Johansen, Gitte Pedersen, Lars Nørregård Nielsen, Jesper Bonde, Henrik Westh, Niels Obel, Terese L Katzenstein, Anne-Mette Lebech
BACKGROUND: No Danish guidelines for screening of sexually transmitted infections (STIs) in women living with HIV (WLWH) exist, except for annual syphilis testing. Drug-drug interaction between hormonal contraceptives and some types of highly active antiretroviral therapy (HAART) occurs. We assessed prevalence of STIs, contraceptive choices and predictors of condom use in a cohort of WLWH in Denmark. METHODS: WLWH consecutively enrolled during their outpatient visits from 2011 to 2012...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/26762155/syphilitic-orchitis-mimicking-a-testicular-tumor-in-a-clinically-occult-hiv-infected-young-man-a-case-report-with-emphasis-on-a-challenging-pathological-diagnosis
#16
Chia-Ying Chu, Wei-Yu Chen, Shauh-Der Yeh, Huey-Min Yeh, Chia-Lang Fang
BACKGROUND: Syphilitic orchitis is a rare manifestation of gumma in tertiary syphilis, microscopically typically characterized by multiple discrete granulomas with central necrosis and peripheral fibrosis. We report a case of syphilitic orchitis mimicking a testicular tumor with atypical histological features. CASE PRESENTATION: A 33-year-old clinically occult HIV-infected man had a testicular tumor. A radical orchiectomy was performed, and a histological examination showed an acute and chronic interstitial inflammatory lesion as well as spindle cell proliferation, without typical gumma formation, necessitating the differential diagnosis having to be made from a panel of etiological factors...
January 14, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/26389000/condurango-gonolobus-condurango-extract-activates-fas-receptor-and-depolarizes-mitochondrial-membrane-potential-to-induce-ros-dependent-apoptosis-in-cancer-cells-in-vitro-ce-treatment-on-hela-a-ros-dependent-mechanism
#17
Kausik Bishayee, Jesmin Mondal, Sourav Sikdar, Anisur Rahman Khuda-Bukhsh
OBJECTIVES: Condurango (Gonolobus condurango) extract is used by complementary and alternative medicine (CAM) practitioners as a traditional medicine, including homeopathy, mainly for the treatment of syphilis. Condurango bark extract is also known to reduce tumor volume, but the underlying molecular mechanisms still remain unclear. METHODS: Using a cervical cancer cell line (HeLa) as our model, the molecular events behind condurango extract's (CE's) anticancer effect were investigated by using flow cytometry, immunoblotting and reverse transcriptase-polymerase chain reaction (RT-PCR)...
September 2015: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/26378262/painful-and-multiple-anogenital-lesions-are-common-in-men-with-treponema-pallidum-pcr-positive-primary-syphilis-without-herpes-simplex-virus-coinfection-a-cross-sectional-clinic-based-study
#18
Janet M Towns, David E Leslie, Ian Denham, Francesca Azzato, Christopher K Fairley, Marcus Chen
BACKGROUND: Chancres, the hallmark of primary syphilis, are classically described as single, painless ulcers at the site of Treponema pallidum inoculation. We aimed to determine the frequency of painful or multiple anogenital lesions of primary syphilis among men, whether there was concurrent herpes simplex virus (HSV) infection and whether HIV status altered clinical presentations. METHODS: This study was conducted among men with T. pallidum PCR-positive lesions, attending a clinic in Melbourne, Australia, between 2009 and 2014...
March 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/26311859/comparison-of-diagnostic-accuracy-of-pcr-targeting-the-47-kilodalton-protein-membrane-gene-of-treponema-pallidum-and-pcr-targeting-the-dna-polymerase-i-gene-systematic-review-and-meta-analysis
#19
REVIEW
Angèle Gayet-Ageron, Christophe Combescure, Stephan Lautenschlager, Béatrice Ninet, Thomas V Perneger
Treponema pallidum PCR (Tp-PCR) testing now is recommended as a valid tool for the diagnosis of primary or secondary syphilis. The objectives were to systematically review and determine the optimal specific target gene to be used for Tp-PCR. Comparisons of the performance of the two main targets are tpp47 and polA genes were done using meta-analysis. Three electronic bibliographic databases, representing abstract books from five conferences specialized in infectious diseases from January 1990 to March 2015, were searched...
November 2015: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/26292307/incidental-syphilis-diagnosed-by-real-time-pcr-screening-of-urine-samples
#20
LETTER
Grégory Dubourg, Sophie Edouard, Elsa Prudent, Pierre-Edouard Fournier, Didier Raoult
No abstract text is available yet for this article.
November 2015: Journal of Clinical Microbiology
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