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https://www.readbyqxmd.com/read/28427851/circulating-ceruloplasmin-ceruloplasmin-associated-genes-and-the-incidence-of-atrial-fibrillation-in-the-atherosclerosis-risk-in-communities-study
#1
Antonio P Arenas de Larriva, Faye L Norby, Lin Y Chen, Elsayed Z Soliman, Ron C Hoogeveen, Dan E Arking, Laura R Loehr, Alvaro Alonso
BACKGROUND: Ceruloplasmin (CP) may promote structural changes in the atrium making it more arrhythmogenic. We assessed the associations between CP, CP-associated genetic variants, and incident atrial fibrillation (AF) in the Atherosclerosis Risk in Communities (ARIC) study. METHODS AND RESULTS: We studied 10,059 men and women without prevalent AF aged 53 to 75years in 1996-1998 and followed through 2012. Circulating CP was measured in stored blood samples obtained in 1996-1998...
April 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28426734/study-of-deaths-by-suicide-of-homosexual-prisoners-in-nazi-sachsenhausen-concentration-camp
#2
Esther Cuerda-Galindo, Francisco López-Muñoz, Matthis Krischel, Astrid Ley
Living conditions in Nazi concentration camps were harsh and inhumane, leading many prisoners to commit suicide. Sachsenhausen (Oranienburg, Germany) was a concentration camp that operated from 1936 to 1945. More than 200,000 people were detained there under Nazi rule. This study analyzes deaths classified as suicides by inmates in this camp, classified as homosexuals, both according to the surviving Nazi files. This collective was especially repressed by the Nazi authorities. Data was collected from the archives of Sachsenhausen Memorial and the International Tracing Service in Bad Arolsen...
2017: PloS One
https://www.readbyqxmd.com/read/28419901/does-exclusion-of-cancers-registered-only-from-death-certificate-information-diminish-socio-demographic-disparities-in-recorded-survival
#3
Hanna E Tervonen, David Roder, Stephen Morrell, Hui You, David C Currow
BACKGROUND: Death Certificate Only (DCO) cancer cases are commonly excluded from survival analyses due to unknown survival time. This study examines whether socio-demographic factors are associated with DCO diagnosis, and the potential effects of excluding DCO cases on socio-demographic cancer survival disparities in NSW, Australia. METHODS: NSW Cancer Registry data for cases diagnosed in 2000-2008 were used in this study. Logistic regression was used to estimate the odds of DCO registration by socio-demographic sub-group (socio-economic disadvantage, residential remoteness, country of birth, age at diagnosis)...
April 15, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28416129/increase-in-parkinson-s-disease-related-mortality-among-males-in-northern-italy
#4
Ugo Fedeli, Elena Schievano
BACKGROUND: According to standard mortality statistics based on the underlying cause of death (UCOD), mortality from Parkinson's disease (PD) is increasing in most European countries. However, mortality trends are better investigated taking into account all the diseases reported in the death certificate (multiple causes of death approach, MCOD). METHODS: All deaths of residents in the Veneto Region (Northern Italy) aged≥45 years with any mention of PD were extracted from 2008 to 2015...
April 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28413928/the-oncology-specialist-s-role-in-polst-form-completion
#5
Austin J Lammers, Dana M Zive, Susan W Tolle, Erik K Fromme
INTRODUCTION: Patients with cancer and oncology professional societies believe that advance care planning is important, but we know little of who actually has this conversation. Physician Orders for Life-Sustaining Treatment (POLST) forms can help to document these important conversations to ensure patients receive the level of treatment they want. We therefore sought to determine the specialty of those signing POLST forms for patients who died of cancer to better understand who is having this discussion with patients...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/28410291/role-of-induction-chemotherapy-prior-to-chemoradiation-in-head-and-neck-squamous-cell-cancer-systematic-review-and-meta-analysis
#6
Liat Vidal, Irit Ben Aharon, Dror Limon, Ezra Cohen, Aron Popovtzer
The objective of this study was to review and assess the impact of additional induction chemotherapy to concomitant chemoradiation in head and neck squamous cell cancer. We performed a comparative systematic review and meta-analysis of clinical trials of induction chemotherapy + chemoradiation and chemoradiation alone in this setting. We identified trials randomizing 1314 patients (published 2004-2015). A non-statistically significant trend was observed in favor of induction chemotherapy + chemoradiation on overall survival (hazard ratio, 0...
March 2017: Cancer Journal
https://www.readbyqxmd.com/read/28387784/subacute-sclerosing-panencephalitis-the-devastating-measles-complication-that-might-be-more-common-than-previously-estimated
#7
Kristen A Wendorf, Kathleen Winter, Jennifer Zipprich, Rob Schechter, Jill K Hacker, Chris Preas, James D Cherry, Carol Glaser, Kathleen Harriman
Background: Subacute sclerosing panencephalitis (SSPE) is a fatal complication of measles. We reviewed California cases from 1998-2015 to understand risk factors for SPPE and estimate incidence. Methods: SSPE cases had clinically compatible symptoms and measles antibody detection in cerebrospinal fluid (CSF) or medical record documentation of SSPE. Cases were identified though a state death certificate search, Centers for Disease Control and Prevention reports, or investigations for undiagnosed neurologic disease...
April 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28381400/association-of-plasma-7-ketocholesterol-with-cardiovascular-outcomes-and-total-mortality-in-patients-with-coronary-artery-disease
#8
Jiayi Song, Duan Wang, Hongen Chen, Xiuwei Huang, Yuan Zhong, Nan Jiang, Chaogang Chen, Min Xia
Rationale: 7-Ketocholesterol (7-KC), a form of cholesterol oxidation product, plays an essential role in the atherogenesis in animal models. Objective: We sought to determine the association of circulating 7-KC with clinical cardiovascular outcomes and total mortality in patients with stable coronary artery disease (CAD). Methods and Results: We measured the plasma 7-KC levels by high performance liquid chromatography in a prospective cohort study of 1016 patients (mean age 63.2 years, male 61.1%) with stable CAD who were recruited from December 2008 to December 2011, and followed up for a median of 4...
April 5, 2017: Circulation Research
https://www.readbyqxmd.com/read/28379784/evaluation-of-diagnostic-codes-in-morbidity-and-mortality-data-sources-for-heat-related-illness-surveillance
#9
Laurel Harduar Morano, Sharon Watkins
OBJECTIVES: The primary objective of this study was to identify patients with heat-related illness (HRI) using codes for heat-related injury diagnosis and external cause of injury in 3 administrative data sets: emergency department (ED) visit records, hospital discharge records, and death certificates. METHODS: We obtained data on ED visits, hospitalizations, and deaths for Florida residents for May 1 through October 31, 2005-2012. To identify patients with HRI, we used codes from the International Classification of Diseases, Ninth Revision, Clinical Modification ( ICD-9-CM) to search data on ED visits and hospitalizations and codes from the International Classification of Diseases, Tenth Revision ( ICD-10) to search data on deaths...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/28373748/cancer-incidence-and-mortality-in-china-in-2013-an-analysis-based-on-urbanization-level
#10
Wanqing Chen, Rongshou Zheng, Siwei Zhang, Hongmei Zeng, Tingting Zuo, Changfa Xia, Zhixun Yang, Jie He
OBJECTIVE: To explore the cancer patterns in areas with different urbanization rates (URR) in China with data from 255 population-based cancer registries in 2013, collected by the National Central Cancer Registry (NCCR). METHODS: There were 347 cancer registries submitted cancer incidence and deaths occurred in 2013 to NCCR. All those data were checked and evaluated based on the NCCR criteria of data quality, and qualified data from 255 registries were used for this analysis...
February 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28369710/potential-value-of-impaired-cognition-in-stroke-prediction-a-u-k-population-based-study
#11
Blossom C M Stephan, Kathryn Richardson, George M Savva, Fiona E Matthews, Carol Brayne, Vladimir Hachinski
OBJECTIVES: To determine whether the association between impaired cognition and greater risk of incident stroke is also observed when cognitive impairment is defined using different criteria for mild cognitive impairment (MCI). DESIGN: Prospective cohort study with 10 years of follow-up. SETTING: Large multicentre study in the United Kingdom. PARTICIPANTS: Individuals (aged 64-105) from the Medical Research Council Cognitive Function and Ageing Study (N = 13,004)...
April 3, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28368943/the-impact-of-forced-migration-on-mortality-a-cohort-study-of-242-075-finns-from-1939-2010
#12
Jari Haukka, Jaana Suvisaari, Matti Sarvimäki, Pekka Martikainen
BACKGROUND: The stresses and life changes associated with migration may have harmful long-term health effects, especially for mental health. These effects are exceedingly difficult to establish, because migrants are typically a highly selected group. METHODS: We examined the impact of migration on health using 'naturally occurring' historical events. In this paper, we use the forced migration of 11% of the Finnish population after WWII as such a natural experiment...
March 29, 2017: Epidemiology
https://www.readbyqxmd.com/read/28361447/reproductive-factors-and-incidence-of-endometrial-cancer-in-u-s-black-women
#13
Todd R Sponholtz, Julie R Palmer, Lynn Rosenberg, Elizabeth E Hatch, Lucile L Adams-Campbell, Lauren A Wise
PURPOSE: Previous studies have shown that reproductive history is a strong determinant of endometrial cancer risk among white women. Less is known about how reproductive history affects endometrial cancer risk among black women, whose incidence and mortality differ from white women. We investigated the associations of age at menarche, parity, timing of births, and menopausal age with endometrial cancer in the Black Women's Health Study, a prospective cohort study. METHODS: Every 2 years from 1995 to 2013, 47,555 participants with intact uteri at baseline in 1995 completed questionnaires on reproductive and medical history, and lifestyle factors...
March 30, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28361063/survival-of-primary-lung-cancer-patients-in-brunei-darussalam-1987-2012
#14
Lin Naing, Amalina Abdullah, Syafiq Abdullah, Nurolaini Kifli
BACKGROUND: In 2009 to 2011, the commonest cause of death was by cancer in Brunei Darussalam, and 16.5% and 19.5% of cancer deaths were due to lung cancer in 2004 and 2011 respectively. This study was to investigate the survival of lung cancer patients in Brunei Darussalam. METHODS: This retrospective cohort study was conducted in 2013 & 2014 for those who were diagnosed as primary lung cancer in the period of 1987 to 2012. Data were retrieved from patients' medical records and death certificates using pretested data collection form...
March 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28359386/delhi-s-health-system-exceptionalism-inadequate-progress-for-a-global-capital-city
#15
M K Gusmano, V G Rodwin, D Weisz
OBJECTIVES: India has proclaimed commitment to the goal of Universal Health Coverage and Delhi, the National Capital Territory, has increased investment in public health and other health services over the past decade. The research investigates whether Delhi's increased investment in health over this period is associated with a reduction in premature deaths, after the age of 1 year, which could have been avoided with better access to effective health care interventions (amenable mortality)...
April 2017: Public Health
https://www.readbyqxmd.com/read/28357162/health-health-care-and-systems-science-emerging-paradigm
#16
REVIEW
Ivo Janecka
Health is a continuum of an optimized state of a biologic system, an outcome of positive relationships with the self and others. A healthy system follows the principles of systems science derived from observations of nature, highlighting the character of relationships as the key determinant. Relationships evolve from our decisions, which are consequential to the function of our own biologic system on all levels, including the genome, where epigenetics impact our morphology. In healthy systems, decisions emanate from the reciprocal collaboration of hippocampal memory and the executive prefrontal cortex...
February 15, 2017: Curēus
https://www.readbyqxmd.com/read/28350996/quality-measures-of-the-population-based-finnish-cancer-registry-indicate-sound-data-quality-for-solid-malignant-tumours
#17
Maarit K Leinonen, Joonas Miettinen, Sanna Heikkinen, Janne Pitkäniemi, Nea Malila
BACKGROUND: The Finnish Cancer Registry (FCR) has collected population-based data on cancer incidence for scientific research and statistical purposes since 1953. Our aim was to provide a comprehensive quality assessment of the current cancer registry data in Finland. METHODS: We used established quantitative and semi-quantitative techniques to address four main dimensions of data quality: completeness, comparability, validity and timeliness for the period 1953-2013, with a special focus on cancers diagnosed in 2009-2013...
March 25, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28348493/mortality-associated-with-hepatitis-c-and-hepatitis-b-virus-infection-a-nationwide-study-on-multiple-causes-of-death-data
#18
Ugo Fedeli, Enrico Grande, Francesco Grippo, Luisa Frova
AIM: To analyze mortality associated with hepatitis C virus (HCV) and hepatitis B virus (HBV) infection in Italy. METHODS: Death certificates mentioning either HBV or HCV infection were retrieved from the Italian National Cause of Death Register for the years 2011-2013. Mortality rates and proportional mortality (percentage of deaths with mention of HCV/HBV among all registered deaths) were computed by gender and age class. The geographical variability in HCV-related mortality rates was investigated by directly age-standardized rates (European standard population)...
March 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28345203/major-electrocardiographic-abnormality-predicts-support-care-need-certification-and-or-death-in-community-dwelling-older-adults-with-no-history-of-cardiovascular-disease
#19
Tazuo Okuno, Keisuke Watanabe, Kumie Nakajima, Osamu Iritani, Hiroshi Yano, Takuro Morita, Taroh Himeno, Yuta Igarashi, Masashi Okuro, Shigeto Morimoto
AIM: Not only cardiovascular disease (CVD) itself, but also subclinical major electrocardiographic (ECG) abnormalities are related to frailty in older adults. We investigated whether major ECG abnormality was associated with first support/care-need certification in Long-Term Care Insurance or death in community-dwelling older adults. METHODS: We analyzed 1078 community-dwelling older adults with no history of certification aged 65-94 years. Relationships between baseline major ECG abnormality and risk of first certification or death were estimated using the Cox proportional hazards model...
March 27, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28341087/the-impact-of-a-pediatric-emergency-department-facility-verification-system-on-pediatric-mortality-rates-in-arizona
#20
Amber Rice, Jennifer Dudek, Toni Gross, Tomi St Mars, Dale Woolridge
BACKGROUND: The Emergency Medical Services for Children State Partnership Program, as well as the Institute of Medicine report on pediatric emergency care, encourages recognition of emergency departments (EDs) through categorization and verification systems. Although pediatric verification programs are associated with greater pediatric readiness, clinical outcome data have been lacking to track the effects and patient-centered outcomes by implementing such programs. OBJECTIVE: To describe pediatric mortality rates prior to and after implementation of a pediatric emergency facility verification system in Arizona...
March 21, 2017: Journal of Emergency Medicine
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