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https://www.readbyqxmd.com/read/27905126/ameliorating-effects-of-fennel-and-cumin-extracts-on-sperm-quality-and-spermatogenic-cells-apoptosis-by-inducing-weight-loss-and-reducing-leptin-concentration-in-diet-induced-obese-rats
#1
R Nejatbakhsh, S Riyahi, A Farrokhi, S Rostamkhani, S Mahmazi, A Yazdinezhad, M Kazemi, S Shokri
This study was established a model of obesity to estimate the impact of fennel and cumin as anti-obesity extracts on body weight, body mass index (BMI), food consumption, leptin concentration, sperm quality and testis architecture to determine the reversibility of reproductive function of obese animals. Male rats were randomly assigned to either a normal or high-fat diet for 8 weeks. Then, we divided 56 adult rats into seven groups: control (CO); obesity (OB); fennel 100 and 200 mg/kg; cumin 50 and 100 mg/kg; and fennel 100 mg/kg plus cumin 50 mg/kg...
November 30, 2016: Andrologia
https://www.readbyqxmd.com/read/27904549/effects-of-nigella-sativa-supplementation-on-blood-parameters-and-anthropometric-indices-in-adults-a-systematic-review-on-clinical-trials
#2
REVIEW
Alireza Mohtashami, Mohammad Hasan Entezari
BACKGROUND: Nigella sativa (N. sativa) has been used in traditional medicine and several studies have been performed in the last decades to reveal the effects of it on different medical disorders such as diabetes, dyslipidemia, hypertension, and obesity. We evaluated the effects of N. sativa supplementation on lipid profiles, glycemic control, blood pressure (BP), and some anthropometric indices in humans. MATERIALS AND METHODS: A search on published studies was done by using databases including PubMed, Google Scholar, Thomas Reuters Web of Science, and Cochrane...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27830269/inhibition-of-the-multidrug-efflux-pump-lmrs-from-staphylococcus-aureus-by-cumin-spice-cuminum-cyminum
#3
Prathusha Kakarla, Jared Floyd, MunMun Mukherjee, Amith R Devireddy, Madhuri A Inupakutika, Indrika Ranweera, Ranjana Kc, Ugina 'Shrestha, Upender Rao Cheeti, Thomas Mark Willmon, Jaclyn Adams, Merissa Bruns, Shravan Kumar Gunda, Manuel F Varela
Staphylococcus aureus is a serious causative agent of infectious disease. Multidrug-resistant strains like methicillin-resistant S. aureus compromise treatment efficacy, causing significant morbidity and mortality. Active efflux represents a major antimicrobial resistance mechanism. The proton-driven multidrug efflux pump, LmrS, actively exports structurally distinct antimicrobials. To circumvent resistance and restore clinical efficacy of antibiotics, efflux pump inhibitors are necessary, and natural edible spices like cumin are potential candidates...
November 9, 2016: Archives of Microbiology
https://www.readbyqxmd.com/read/27808391/genetic-linkage-between-protein-and-dna-polymorphisms-and-antioxidant-capacity-of-cuminum-cyminum-l-accessions
#4
E Abdelhaliem, A A Al-Huqail
This study aimed to link the genetic variation observed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and random amplified polymorphic DNA (RAPD) analysis among 11 Cuminum cyminum L. accessions, collected from diverse ecogeographical areas in Saudi Arabia, with their antioxidant capacity to better identify potential genotypes for breeding programs for this medicinal spice. SDS-PAGE analysis revealed genetic variation among cumin germplasms and distinct polymorphisms (100%). Protein polymorphisms were identified based on the number of polypeptide bands (288) with molecular weights ranging from 13...
October 6, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27802299/protective-effects-of-essential-oils-as-natural-antioxidants-against-hepatotoxicity-induced-by-cyclophosphamide-in-mice
#5
Salah A Sheweita, Lobna S El-Hosseiny, Munther A Nashashibi
Clinical application of cyclophosphamide (CP) as an anticancer drug is often limited due to its toxicity. CP is metabolized mainly in the liver by cytochrome P450 system into acrolein which is the proximate toxic metabolite. Many different natural antioxidants were found to alleviate the toxic effects of various toxic agents via different mechanisms. Therefore, the present study aimed at investigating the role of essential oils extracted from fennel, cumin and clove as natural antioxidants in the alleviation of hepatotoxicity induced by CP through assessment of hepatotoxicity biomarkers (AST, ALT, ALP), histopathology of liver tissues as well as other biochemical parameters involved in the metabolism of CP...
2016: PloS One
https://www.readbyqxmd.com/read/27781121/the-effect-of-cumin-cyminum-l-plus-lime-administration-on-weight-loss-and-metabolic-status-in-overweight-subjects-a-randomized-double-blind-placebo-controlled-clinical-trial
#6
Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Fatemeh Abedi, Nasrin Sharifi, Fatemeh Karamali, Zohreh Fakhrieh Kashan, Zatollah Asemi
BACKGROUND: Limited data are available regarding the effects of combined administration of Cumin cyminum L. and lime on weight loss and metabolic profiles among subjects with overweight subjects. OBJECTIVES: The current study aimed to assess the effects of combined administration of Cumin cyminum L. and lime on weight loss and metabolic profiles among subjects with overweight. PATIENTS AND METHODS: This randomized double-blind placebo-controlled clinical trial was conducted on 72 subjects with overweight, aged 18 - 50 years old...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27781067/quantitative-scrutinization-of-aflatoxins-in-different-spices-from-pakistan
#7
Narjis Naz, Aiza Kashif, Kinza Kanwal, Abdul Muqeet Khan, Mateen Abbas
The current research work aimed to access the contamination level of aflatoxins B1, B2, G1, and G2 in the household spices that are widely consumed in huge amounts. 200 different spice samples, 100 packed and 100 unpacked, were analyzed for the aflatoxins profile by HPLC with an incidence of 61.5% contamination out of which 53.66% samples exceed the EU limit. The results disclosed that the unpacked samples are more contaminated as compared to the packed samples except for white cumin seeds. Among packed and unpacked samples of spices, the maximum value of aflatoxins was detected in fennel, that is, 27...
2016: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/27775713/small-molecule-factor-d-inhibitors-targeting-the-alternative-complement-pathway
#8
Jürgen Maibaum, Sha-Mei Liao, Anna Vulpetti, Nils Ostermann, Stefan Randl, Simon Rüdisser, Edwige Lorthiois, Paul Erbel, Bernd Kinzel, Fabrice A Kolb, Samuel Barbieri, Julia Wagner, Corinne Durand, Kamal Fettis, Solene Dussauge, Nicola Hughes, Omar Delgado, Ulrich Hommel, Ty Gould, Aengus Mac Sweeney, Bernd Gerhartz, Frederic Cumin, Stefanie Flohr, Anna Schubart, Bruce Jaffee, Richard Harrison, Antonio Maria Risitano, Jörg Eder, Karen Anderson
Complement is a key component of the innate immune system, recognizing pathogens and promoting their elimination. Complement component 3 (C3) is the central component of the system. Activation of C3 can be initiated by three distinct routes-the classical, the lectin and the alternative pathways-with the alternative pathway also acting as an amplification loop for the other two pathways. The protease factor D (FD) is essential for this amplification process, which, when dysregulated, predisposes individuals to diverse disorders including age-related macular degeneration and paroxysmal nocturnal hemoglobinuria (PNH)...
October 24, 2016: Nature Chemical Biology
https://www.readbyqxmd.com/read/27774425/a-case-series-of-the-effects-of-a-novel-composition-of-a-traditional-natural-preparation-for-the-treatment-of-psoriasis
#9
A Michalsen, O Eddin, A Salama
The objective of this study was to assess the effectiveness of a specific composition of a traditional herbal preparation (DurrDerma) in adult patients with moderate to severe skin psoriasis. The preparation is a newly developed topical combination containing plant-based extracts traditionally used in skin disease as black cumin, olive oil, tea tree oil, cocoa butter completed by vitamin A and vitamin B12. We documented the effectiveness of the preparation in a first case series. A total of 12 patients (8 males and 4 females, 21-86 y) with manifest and treatment-resistant psoriasis were included and treated for 12 weeks...
October 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27752803/nigella-sativa-oil-reduces-extrapyramidal-symptoms-eps-like-behavior-in-haloperidol-treated-rats
#10
Tafheem Malik, Sheema Hasan, Shahid Pervez, Tasneem Fatima, Darakhshan Jabeen Haleem
The symptoms of Parkinsonism and oral dyskinesia have been showing to be induced by neuroleptics that significantly affect its clinical use. In this study, we investigate whether Nigella sativa-oil (NS) (black cumin seeds)-a traditional medicine used for the seizure treatment in eastern country-may reduce the haloperidol (HAL)-induced extrapyramidal symptoms (EPS)-like behavior in rats. After combine treatment with HAL (1 mg/kg) on NS (0.2 ml/rat), rats displayed a significant decreased EPS-like behavior including movement disorders and oral dyskinesia as compared to controls...
December 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27736848/can-team-training-make-surgery-safer-lessons-for-national-implementation-of-a-simulation-based-programme
#11
Jennifer Weller, Ian Civil, Jane Torrie, David Cumin, Alexander Garden, Arden Corter, Alan Merry
AIM: Unintended patient harm is a major contributor to poor outcomes for surgical patients and often reflects failures in teamwork. To address this we developed a Multidisciplinary Operating Room Simulation (MORSim) intervention to improve teamwork in the operating room (OR) and piloted it with 20 OR teams in two of the 20 District Health Boards in New Zealand prior to national implementation. In this study, we describe the experience of those exposed to the intervention, challenges to implementing changes in clinical practice and suggestions for successful implementation of the programme at a regional or national level...
October 14, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27725613/rapid-discrimination-of-closely-related-seed-herbs-cumin-caraway-and-fennel-by-direct-analysis-in-real-time-mass-spectrometry-dart-ms
#12
Borbála Antal, Ákos Kuki, Lajos Nagy, Tibor Nagy, Miklós Zsuga, Márta M-Hamvas, Gábor Vasas, Sándor Kéki
Direct analysis in real time mass spectrometry (DART-MS) was applied as a rapid method for the discrimination of the spices and traditional medicines cumin (Cuminum cyminum L.), caraway (Carum carvi L.), and fennel (Foeniculum vulgare Mill.). The seeds of these plants were analyzed without sample preparation by DART ion source coupled with quadrupole time-of-flight (QTOF) tandem mass spectrometry. The relatively clean DART spectra showed characteristic patterns, fingerprints, for each herb. It was found that a marker compound can be assigned to each species that can identify unambiguously these plants...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/27664636/spices-in-the-management-of-diabetes-mellitus
#13
REVIEW
Xinyan Bi, Joseph Lim, Christiani Jeyakumar Henry
Diabetes mellitus (DM) remains a major health care problem worldwide both in developing and developed countries. Many factors, including age, obesity, sex, and diet, are involved in the etiology of DM. Nowadays, drug and dietetic therapies are the two major approaches used for prevention and control of DM. Compared to drug therapy, a resurgence of interest in using diet to manage and treat DM has emerged in recent years. Conventional dietary methods to treat DM include the use of culinary herbs and/or spices...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27652055/the-myth-of-oral-hygiene-using-synthetic-mouthwash-products
#14
Ghulam Zahara Jahangir, Durre Shahwar Ashraf, Idrees Ahmad Nasir, Madeha Sadiq, Sobia Shahzad, Farah Naz, Muhammad Iqbal, Afifa Saeed
The synthetic oral cleansing and teeth whitening products like mouthwashes exert adverse effects on teeth, gums and mucous membrane of oral cavity and their extensive use is being criticized. Determining the effect of frequent use of mouthwashes, human cheek cells and their DNA have been studied. Five mouthwash brands were tested and their effects were examined on membrane and DNA of human cheek cells which were found to be very expressive and severe. The DNA, also, received severe damage and breaks developed in its double stranded structure resulting in detachment of small fragments from DNA...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27649635/recent-advances-on-the-anti-cancer-properties-of-nigella-sativa-a-widely-used-food-additive
#15
Amin F Majdalawieh, Muneera W Fayyad
The use of naturally-occurring agents to regulate tumorigenesis is on the rise. Several herbal extracts, pure plant-derived active constituents, and food additives have been reported to possess potent anti-cancer properties and cancer-ameliorating effects. The wide-range anti-cancer effects of Nigella sativa, also known as black seed or black cumin, have been extensively studied using different in vitro and in vivo models. Here, we provide a comprehensive, analytical review of the reported anti-cancer properties of N...
July 2016: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/27581377/assessing-the-similarity-of-mental-models-of-operating-room-team-members-and-implications-for-patient-safety-a-prospective-replicated-study
#16
Ivana Nakarada-Kordic, Jennifer M Weller, Craig S Webster, David Cumin, Christopher Frampton, Matt Boyd, Alan F Merry
BACKGROUND: Patient safety depends on effective teamwork. The similarity of team members' mental models - or their shared understanding-regarding clinical tasks is likely to influence the effectiveness of teamwork. Mental models have not been measured in the complex, high-acuity environment of the operating room (OR), where professionals of different backgrounds must work together to achieve the best surgical outcome for each patient. Therefore, we aimed to explore the similarity of mental models of task sequence and of responsibility for task within multidisciplinary OR teams...
2016: BMC Medical Education
https://www.readbyqxmd.com/read/27579151/nigella-sativa-relieves-the-altered-insulin-receptor-signaling-in-streptozotocin-induced-diabetic-rats-fed-with-a-high-fat-diet
#17
Mahmoud Balbaa, Marwa El-Zeftawy, Doaa Ghareeb, Nabil Taha, Abdel Wahab Mandour
The black cumin (Nigella sativa) "NS" or the black seeds have many pharmacological activities such as antioxidant, anticarcinogenic, antihypertensive, and antidiabetic properties. In this work, streptozotocin-induced diabetic rats fed with a high-fat diet were treated daily with NS oil (NSO) in order to study the effect on the blood glucose, lipid profile, oxidative stress parameters, and the gene expression of some insulin receptor-induced signaling molecules. This treatment was combined also with some drugs (metformin and glimepiride) and the insulin receptor inhibitor I-OMe-AG538...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27553624/nigella-sativa-black-cumin-seed-as-a-biological-detoxifier-in-diet-contaminated-with-aflatoxin-b1
#18
A A Rasouli-Hiq, F Bagherzadeh-Kasmani, M Mehri, M A Karimi-Torshizi
Aflatoxin B1 (AFB1 ) is a common feed contaminant that adversely affects bird performance and product quality. A total of 600 7-day-old quail chicks were randomly allotted to eight experimental groups in a completely randomized design with five replicate pens and 15 quails per pen. Experimental treatments including two levels of AFB1 (0 and 2.5 mg/kg) and 4 levels of Nigella sativa (NS) (0, 0.5, 1.0 and 1.5% of diet) were offered from 7 to 35 days of age to quail chicks. Although feeding of AFB1 impaired gain (G) and feed conversion ratio, dietary NS increased G (p < 0...
August 24, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27536197/effect-of-dietary-antioxidant-supplementation-cuminum-cyminum-on-bacterial-susceptibility-of-diabetes-induced-rats
#19
Gehan Moubarz, Mohamed A Embaby, Nada M Doleib, Mona M Taha
Diabetic patients are at risk of acquiring infections. Chronic low-grade inflammation is an important factor in the pathogenesis of diabetic complication. Diabetes causes generation of reactive oxygen species that increases oxidative stress, which may play a role in the development of complications as immune-deficiency and bacterial infection. The study aimed to investigate the role of a natural antioxidant, cumin, in the improvement of immune functions in diabetes. Diabetes was achieved by interperitoneal injection of streptozotocin (STZ)...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27529277/spices-for-prevention-and-treatment-of-cancers
#20
REVIEW
Jie Zheng, Yue Zhou, Ya Li, Dong-Ping Xu, Sha Li, Hua-Bin Li
Spices have been widely used as food flavorings and folk medicines for thousands of years. Numerous studies have documented the antioxidant, anti-inflammatory and immunomodulatory effects of spices, which might be related to prevention and treatment of several cancers, including lung, liver, breast, stomach, colorectum, cervix, and prostate cancers. Several spices are potential sources for prevention and treatment of cancers, such as Curcuma longa (tumeric), Nigella sativa (black cumin), Zingiber officinale (ginger), Allium sativum (garlic), Crocus sativus (saffron), Piper nigrum (black pepper) and Capsicum annum (chili pepper), which contained several important bioactive compounds, such as curcumin, thymoquinone, piperine and capsaicin...
August 12, 2016: Nutrients
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