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Epstein Bar Virus

Julie D Gibbs, Marino E Leon, Kenia Liu, Johnny Nguyen, Ling Zhang
Extramedullary plasmacytomas, Epstein-Bar virus (EBV) associated, are rarely encountered and usually have a fairly good clinical outcome. EBV+ plasmacytoma may cause a diagnostic dilemma as it phenotypically resembles an aggressive plasmablastic lymphoma (PBL). Herein, we report a unique case with maxillary EBV+ plasmacytoma from a 76-year-old immunocompetent individual.
September 2017: Clinical Case Reports
Ehsan Kakavandi, Ramin Shahbahrami, Hossein Goudarzi, Gita Eslami, Ebrahim Faghihloo
Anoikis is known as a special type of programmed cell death which occurs in response to loss of correct cell-extracellular matrix (ECM) connections. This process could be as pivotal event in normal development and tissue homeostasis and found as important mechanism in cancer invasiveness and metastasis. The persistent infection with oncoviruses including EBV (Epstein Bar virus), HPV (Human Papillomaviruses), HBV (Hepatitis B virus), KSHV (Human herpesvirus 8), HTLV-1 (Human T-lymphotropic virus-1), and HCV (Hepatitis C virus) accounted as one of main risk factor for cancer progression...
August 24, 2017: Journal of Cellular Biochemistry
Mitsuhiro Nishimura, Junjie Wang, Aika Wakata, Kento Sakamoto, Yasuko Mori
Immediate early proteins of human herpesvirus 6A (HHV-6A) are expressed at the outset of lytic infection and thereby regulate viral gene expression. Immediate early protein 2 (IE2) of HHV-6A is a transactivator that drives a variety of promoters. The C-terminal region of HHV-6A IE2 is shared among IE2 homologs in betaherpesviruses and is involved in dimerization, DNA binding, and transcription factor binding. In this study, the structure of the IE2 C-terminal domain (IE2-CTD) was determined by X-ray crystallography at a resolution of 2...
November 1, 2017: Journal of Virology
Qianli Wang, Amy Lingel, Vicki Geiser, Zachary Kwapnoski, Luwen Zhang
Epstein-Barr virus (EBV) is associated with multiple human malignancies. EBV latent membrane protein 1 (LMP1) is required for the efficient transformation of primary B lymphocytes in vitro and possibly in vivo The tumor suppressor p53 plays a seminal role in cancer development. In some EBV-associated cancers, p53 tends to be wild type and overly expressed; however, the effects of p53 on LMP1 expression is not clear. We find LMP1 expression to be associated with p53 expression in EBV-transformed cells under physiological and DNA damaging conditions...
October 15, 2017: Journal of Virology
Thuan Duc Lao, Dung Huu Nguyen, Trong Minh Nguyen, Thuy Ai Huyen Le
Epstein-Bar virus (EBV) is considered to be intimately associated with development of nasopharyngeal carcinoma (NPC), the most common and high incidence cancer of the head and neck in Asian countries, especially in Vietnam. In this study, we validated associations between highly conserved segments of the EBV genome, including EBNA-1, EBNA-2, LMP-1, LMP-2 and nasopharyngeal cancer, with the aim of applications with non-invasive brush samples for early diagnosis and as a prognostic biomarker. The polymerase chain reaction (PCR) was performed to assess the presence of EBNA-1, EBNA-2, LMP-1, LMP-2 in nasopharyngeal brush samples from Vietnamese NPC patients and non-cancer controls...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Varunsiri Atti, Nathan M Anderson, Mathew B Day
BACKGROUND Myocarditis, defined as inflammation of myocardial tissue of the heart, is an uncommon cardiac presentation and is due to a variety of causes. It affects 1% of the US population, 50% of which is caused by coxsackie B virus. Cardiac tissue is the prime target, and destruction of myocardium results in cardiac failure with fluid overload. CASE REPORT Our patient was a 57-year-old woman with fever, headache, neck pain, and generalized malaise. Her white blood cell count was 13×10³ cells/mm³. Interestingly, lumbar puncture ruled out meningitis...
February 15, 2017: American Journal of Case Reports
Sandra Sunitsch, Magdalena Gilg, Karl Kashofer, Andreas Leithner, Bernadette Liegl-Atzwanger, Christine Beham-Schmid
BACKGROUND: Primary bone lymphomas (PBL) are extremely rare malignant neoplasms. The most commonly described subtype of PBL is diffuse large B-cell lymphoma (DLBCL). DLBCL within peri-prosthetic membrane of a joint is exceedingly rare. To the best of our knowledge this case is the second reported Epstein-Bar-Virus (EBV) negative DLBCL in a peri-prosthetic membrane in the literature. CASE PRESENTATION: We report an 80 year old female patient who developed a DLBCL with chronic inflammation in association to a metallic implant in the left knee...
August 18, 2016: Diagnostic Pathology
Ankur Omer, Poonam Singh
A serious challenge in cancer treatment is to reposition the activity of various already known drug candidates against cancer. There is a need to rewrite and systematically analyze the detailed mechanistic aspect of cellular networks to gain insight into the novel role played by various molecules. Most Human Immunodeficiency Virus infection-associated cancers are caused by oncogenic viruses like Human Papilloma Viruses and Epstein-Bar Virus. As the onset of AIDS-associated cancers marks the severity of AIDS, there might be possible interconnections between the targets and mechanism of both the diseases...
May 2017: Journal of Biomolecular Structure & Dynamics
Hassan Salehi, Marziyeh Salehi, Rasoul Roghanian, Majid Bozari, Shirin Taleifard, Mohamad Mahdi Salehi, Maryam Salehi
BACKGROUND: Epstein-Bar virus (EBV) is the main etiology of infectious mononucleosis (IM) syndrome that is characterized by fever, sore throat, and lymph adenopathy. Since, this virus could be associated with a number of malignancies, some hematologic disorders, and chronic fatigue syndrome, identification of IM is very important. The aim of study was to evaluate the specificity, as well as sensitivity of the two different methods that is, serology versus molecular diagnosis that are currently used for diagnosis of IM...
2016: Advanced Biomedical Research
Zhichao Lin, Dongrong Situ, Xiangzhen Chang, Wenhua Liang, Meiling Zhao, Chengjie Cai, Yang Liu, Jianxing He
OBJECTIVES: Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare but unique subtype of non-small-cell lung cancer (NSCLC). Our study aimed to evaluate clinicopathological characteristics and the value of surgical treatment for LELC and explore the relevant prognostic factors in a relatively large cohort. METHODS: We retrospectively reviewed the medical records of 39 lung LELC patients who underwent pulmonary resection with curative intent between January 2009 and December 2013...
July 2016: Interactive Cardiovascular and Thoracic Surgery
Hans Helmut Niller, Ferenc Banati, Daniel Salamon, Janos Minarovits
Latent Epstein-Bar virus genomes undergo epigenetic modifications which are dependent on the respective tissue type and cellular phenotype. These define distinct viral epigenotypes corresponding with latent viral gene expression profiles. Viral Latent Membrane Proteins 1 and 2A can induce cellular DNA methyltransferases, thereby influencing the methylation status of the viral and cellular genomes. Therefore, not only the viral genomes carry epigenetic modifications, but also the cellular genomes adopt major epigenetic alterations upon EBV infection...
2016: Advances in Experimental Medicine and Biology
Maaike E Ressing, Michiel van Gent, Anna M Gram, Marjolein J G Hooykaas, Sytse J Piersma, Emmanuel J H J Wiertz
Epstein-Bar virus (EBV) is widespread within the human population with over 90% of adults being infected. In response to primary EBV infection, the host mounts an antiviral immune response comprising both innate and adaptive effector functions. Although the immune system can control EBV infection to a large extent, the virus is not cleared. Instead, EBV establishes a latent infection in B lymphocytes characterized by limited viral gene expression. For the production of new viral progeny, EBV reactivates from these latently infected cells...
2015: Current Topics in Microbiology and Immunology
Yuan-Xue Jiang, Zi-Ming Du, Lin Jiao, Qiong Shao, Sha Fu, Jian-Yong Shao, Xiao-Feng Zhu, Ingemar Ernberg, Yu-Hong Li
Overexpression of miR-155 in nasopharygeal carcinoma (NPC) is partly driven by Epstein-Bar virus infection. However the role of miR-155 in NPC oncogenesis is unclear. This study showed that miR-155 inhibitor could inhibit the cell migration in NPC cell lines. ZDHHC2 was identified as a direct target of miR-155 and downregulation of ZDHHC2 prompted cell migration in NPC. Furthermore, reduced ZDHHC2 expression was associated significantly with metastasis and poor survival of NPC patients. Collectively, inhibition of miR-155 suppresses cell migration in NPC through targeting ZDHHC2...
2015: International Journal of Clinical and Experimental Medicine
Naila Makhani, Brenda Banwell, Raymond Tellier, Carmen Yea, Suzanne McGovern, Julia O'Mahony, Jean M Ahorro, Douglas Arnold, A Dessa Sadovnick, Ruth A Marrie, Amit Bar-Or
Epstein-Barr virus (EBV) infection is associated with increased multiple sclerosis (MS) risk. Recently, cytomegalovirus (CMV) infection has been proposed as a protective factor against MS development. We determined EBV, herpes simplex virus, varicella-zoster virus and CMV seroprevalence in 247 prospectively followed children with acquired demyelinating syndromes (ADS). Remote EBV infection was more common in children with MS than those with monophasic ADS while CMV infection was more common in children with monophasic ADS...
March 2016: Multiple Sclerosis: Clinical and Laboratory Research
Samadhi Aparicio-Siegmund, Christoph Garbers
Interleukin (IL)-27 is a multifaceted heterodimeric cytokine with pronounced pro- and anti-inflammatory as well as immunoregulatory functions. It consists of the two subunits p28/IL-30 and Epstein Bar virus-induced protein 3 (EBI3). EBI3 functions as a soluble α-receptor, and IL-27 can therefore directly activate its target cells through a heterodimer of glycoprotein 130 (gp130) and WSX-1. Being a heterodimeric cytokine that signals through gp130, IL-27 is either grouped into the IL-6 or the IL-12 family of cytokines...
October 2015: Cytokine & Growth Factor Reviews
Riccardo Dolcetti
Epstein-Bar virus (EBV) is known to directly drive the neoplastic transformation of lymphoid cells resulting in the development of a variety of lymphoproliferative disorders. Emerging evidence however indicates that this final outcome is also related to the ability of EBV to shape microenvironment making it more conducive to cell transformation. Indeed, EBV up-regulates the production of several soluble factors promoting the growth and/or the survival of lymphoid cells and orchestrates a variety of complex mechanisms favoring their escape from anti-tumor immune responses...
October 2015: Seminars in Cancer Biology
Edwin P Hui, Brigette B Y Ma, K C Allen Chan, Charles M L Chan, Cesar S C Wong, Ka Fai To, Anthony W H Chan, Stewart Y Tung, Wai-Tong Ng, Ashley C Cheng, Victor H F Lee, Stephen L Chan, Herbert H F Loong, Michael K M Kam, Sing-Fai Leung, Rosalie Ho, Frankie Mo, Roger K C Ngan, Anthony T C Chan
BACKGROUND: Single nucleotide polymorphism (SNP) of the excision repair cross-complementing group 1 (ERCC1) gene has been linked with sensitivity to platinum and radiation. The authors hypothesized that the ERCC1 genotype for the SNPs cytosine-to-thymine substitution at codon 118 (C118T) and cytosine-to-adenine substitution at codon 8092 (C8092A) is prognostic in patients with nasopharyngeal carcinoma (NPC) who receive either radiotherapy (RT) or cisplatin plus RT. METHODS: The authors tested their hypothesis using biomarker screening samples from the Hong Kong NPC Study Group 0502 trial, which was a prospective, multicenter clinical trial that used post-RT plasma Epstein-Bar virus (EBV) DNA (pEBV) levels to screen patients with high-risk NPC for adjuvant chemotherapy...
August 15, 2015: Cancer
Allison Ducharme-Smith, Ben Z Katz, Amy E Bobrowski, Carl L Backer, Karen Rychlik, Elfriede Pahl
BACKGROUND: BK polyomavirus (BKV) infection and nephropathy complicate renal allografts; however, their effect in the native kidneys of pediatric heart transplant (HTx) recipients is unknown. We assessed the prevalence of BKV infection and its association with kidney dysfunction in survivors of pediatric HTx. METHODS: A single-center retrospective study compared pediatric (aged <18 years ) HTx recipients, with and without BKV (controls), who received an allograft from May 1989 to July 2013...
February 2015: Journal of Heart and Lung Transplantation
Madhuravasal Krishnan Janani, Jambulingam Malathi, Jyothirmay Biswas, Sudharshan Sridharan, Hajib Naraharirao Madhavan
PURPOSE: To evaluate the diagnostic value of PCR on aqueous humour for detection and genotyping of Epstein Bar Virus in patients with viral retinitis. METHODS: 70 AH samples were collected from 20 HIV positive patients with clinically suspected viral retinitis and 25 patients with serpignous choroiditis and 25 AH from patients undergoing cataract surgery. PCR was performed to screen HHV-1 to HHV-5, Mtb and Toxoplasma gondii. Genotype prevalence was confirmed by phylogenetic analysis targetig EBV...
2015: Ocular Immunology and Inflammation
Arushi Khurana, Constantin A Dasanu
Aplastic anemia (AA) is thought to represent an autoimmune disorder leading to generation of activated CD8+ T-cells that target the bone marrow precursors. Hepatitis associated aplastic anemia (HAAA) is a subtype of aplastic anemia that develops within several months ofan episode of acute hepatitis. Etiologic agents include hepatitis viruses (A-E and G), Epstein-Bar virus, cytomegalovirus, HIV, parvovirus B19, and echoviruses amongst others. However, most HAAA cases are labeled "idiopathic" as the inciting agent cannot be identified...
September 2014: Connecticut Medicine
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