Yukiko Misaki, Daisuke Minakata, Tatsuro Ibe, Ayumi Gomyo, Kazuki Yoshimura, Shun-Ichi Kimura, Yuhei Nakamura, Masakatsu Kawamura, Shunto Kawamura, Junko Takeshita, Nozomu Yoshino, Shimpei Matsumi, Yu Akahoshi, Masaharu Tamaki, Machiko Kusuda, Kazuaki Kameda, Hidenori Wada, Koji Kawamura, Miki Sato, Kiriko Terasako-Saito, Aki Tanihara, Kaoru Hatano, Hideki Nakasone, Ken-Ichi Imadome, Hiroshi Wada, Shinichi Kako, Hisashi Oshiro, Akira Tanaka, Yoshinobu Kanda
Chronic active Epstein-Bar virus infection (CAEBV) is known to cause various symptoms. Although pulmonary artery hypertension (PAH) has been reported as a cardiovascular complication of CAEBV, the mechanisms of PAH and the effects of treatment have not been fully elucidated. We experienced 4 adult patients with CAEBV complicated by PAH. All of them received treatment for PAH with a vasodilator followed by chemotherapy with or without allogeneic hematopoietic cell transplantation for CAEBV. In all of these patients, the transtricuspid pressure gradient improved under treatment with vasodilator, and further improvement was observed under treatment for CAEBV in 3 patients...
October 28, 2022: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy