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https://www.readbyqxmd.com/read/29780739/knowledge-and-attitude-of-dental-health-professionals-about-middle-east-respiratory-syndrome-in-saudi-arabia
#1
Sameer Abdullah Althomairy, Mohammad Abdul Baseer, Mansour Assery, Abdulrahman Dahham Alsaffan
Aim and Objective: This study aims to evaluate the knowledge and attitude of practicing dental health professionals (DHPs) (dentist and dental auxiliaries) toward Middle East Respiratory Syndrome coronavirus (MERS-CoV) in Saudi Arabia. Materials and Methods: A cross-sectional descriptive study was undertaken among practicing DHPs in Saudi Arabia. A total of 202 DHPs participated in this study. Knowledge and attitude were assessed using self-administered and pretested questionnaire...
March 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29772527/a-novel-role-for-cd26-dipeptidyl-peptidase-iv-as-a-therapeutic-target
#2
Kei Ohnuma, Ryo Hatano, Eriko Komiya, Haruna Otsuka, Takumi Itoh, Noriaki Iwao, Yutaro Kaneko, Taketo Yamada, Nam H Dang, Chikao Morimoto
CD26 is a 110 kDa surface glycoprotein with intrinsic dipeptidyl peptidase IV activity that is expressed on numerous cell types and has a multitude of biological functions. The role of CD26 in immune regulation has been extensively characterized, with recent findings elucidating its linkage with signaling pathways and structures involved in T-lymphocyte activation as well as antigen presenting cell-T-cell interaction. In this paper, we will review emerging data on CD26-mediated immune regulation suggesting that CD26 may be an appropriate therapeutic target for the treatment of selected immune disorders as well as Middle East respiratory syndrome coronavirus...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29772254/effect-of-interferon-alpha-and-cyclosporine-treatment-separately-and-in-combination-on-middle-east-respiratory-syndrome-coronavirus-mers-cov-replication-in-a-human-in-vitro-and-ex-vivo-culture-model
#3
H S Li, Denise I T Kuok, M C Cheung, Mandy M T Ng, K C Ng, Kenrie P Y Hui, J S Malik Peiris, Michael C W Chan, John M Nicholls
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has emerged as a coronavirus infection of humans in the past 5 years. Though confined to certain geographical regions of the world, infection has been associated with a case fatality rate of 35%, and this mortality may be higher in ventilated patients. As there are few readily available animal models that accurately mimic human disease, it has been a challenge to ethically determine what optimum treatment strategies can be used for this disease. We used in-vitro and human ex-vivo explant cultures to investigate the effect of two immunomodulatory agents, interferon alpha and cyclosporine, singly and in combination, on MERS-CoV replication...
May 14, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29769348/discovery-and-sequence-analysis-of-four-deltacoronaviruses-from-birds-in-the-middle-east-suggest-interspecies-jumping-and-recombination-as-potential-mechanism-for-avian-to-avian-and-avian-to-mammalian-transmission
#4
Susanna K P Lau, Emily Y M Wong, Chi-Ching Tsang, Syed Shakeel Ahmed, Rex K H Au-Yeung, Kwok-Yung Yuen, Ulrich Wernery, Patrick C Y Woo
The emergence of Middle East respiratory syndrome showed once again that coronaviruses (CoVs) in animals are potential source for epidemics in humans. To explore the diversity of deltacoronaviruses in animals in the Middle East, we tested fecal samples from 1,356 mammals and birds in Dubai. Four novel deltacoronaviruses were detected from eight birds of four species by RT-PCR: FalCoV UAE-HKU27 from a falcon, HouCoV UAE-HKU28 from a houbara bustard, PiCoV UAE-HKU29 from a pigeon and QuaCoV UAE-HKU30 from five quails...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29763640/development-of-fluorescent-reverse-transcription-loop-mediated-isothermal-amplification-rt-lamp-using-quenching-probes-for-the-detection-of-the-middle-east-respiratory-syndrome-coronavirus
#5
Kazuya Shirato, Shohei Semba, Sherif A El-Kafrawy, Ahmed M Hassan, Ahmed M Tolah, Ikuyo Takayama, Tsutomu Kageyama, Tsugunori Notomi, Wataru Kamitani, Shutoku Matsuyama, Esam Ibraheem Azhar
Clinical detection of Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) in patients is achieved using genetic diagnostic methods, such as real-time RT-PCR assay. Previously, we developed a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay for the detection of MERS-CoV [Virol J. 2014. 11:139]. Generally, amplification of RT-LAMP is monitored by the turbidity induced by precipitation of magnesium pyrophosphate with newly synthesized DNA. However, this mechanism cannot completely exclude the possibility of unexpected reactions...
May 12, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29757717/radiographic-and-ct-features-of-viral-pneumonia
#6
Hyun Jung Koo, Soyeoun Lim, Jooae Choe, Sang-Ho Choi, Heungsup Sung, Kyung-Hyun Do
Viruses are the most common causes of respiratory infection. The imaging findings of viral pneumonia are diverse and overlap with those of other nonviral infectious and inflammatory conditions. However, identification of the underlying viral pathogens may not always be easy. There are a number of indicators for identifying viral pathogens on the basis of imaging patterns, which are associated with the pathogenesis of viral infections. Viruses in the same viral family share a similar pathogenesis of pneumonia, and the imaging patterns have distinguishable characteristics...
May 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29753119/replicative-virus-shedding-in-the-respiratory-tract-of-the-patients-with-middle-east-respiratory-syndrome-coronavirus-infection
#7
Wan Beom Park, Leo Lm Poon, Su-Jin Choi, Pyoeng Gyun Choe, Kyoung-Ho Song, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Sang Won Park, Nam Joong Kim, Malik Peiris, Myoung-Don Oh
BACKGROUND: Information on the duration of replicative Middle East respiratory syndrome coronavirus (MERS-CoV) shedding is important for infection control. Detection of MERS-CoV subgenomic mRNAs indicates the virus is replicative. We examined the duration for detecting MERS-CoV subgenomic mRNA compared with genomic RNA in diverse respiratory specimens METHODS: From upper and lower respiratory samples of 17 MERS-CoV-infected patients, MERS-CoV subgenomic mRNA was detected by reverse transcription polymerase chain reaction (RT-PCR) and MERS-CoV genomic RNA was done by real time RT-PCR...
May 9, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29739720/heterologous-prime-boost-vaccination-with-adenoviral-vector-and-protein-nanoparticles-induces-both-th1-and-th2-responses-against-middle-east-respiratory-syndrome-coronavirus
#8
Seo-Yeon Jung, Kyung Won Kang, Eun-Young Lee, Dong-Won Seo, Hong-Lim Kim, Hak Kim, TaeWoo Kwon, Hye-Lim Park, Hun Kim, Sang-Myeong Lee, Jae-Hwan Nam
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic and zoonotic virus with a fatality rate in humans of over 35%. Although several vaccine candidates have been developed, there is still no clinically available vaccine for MERS-CoV. In this study, we developed two types of MERS-CoV vaccines: a recombinant adenovirus serotype 5 encoding the MERS-CoV spike gene (Ad5/MERS) and spike protein nanoparticles formulated with aluminum (alum) adjuvant. Next, we tested a heterologous prime-boost vaccine strategy, which compared priming with Ad5/MERS and boosting with spike protein nanoparticles and vice versa, with homologous prime-boost vaccination comprising priming and boosting with either spike protein nanoparticles or Ad5/MERS...
May 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29737284/middle-east-respiratory-syndrome-coronavirus-mers-mers-cov
#9
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Disease-a-month: DM
https://www.readbyqxmd.com/read/29732571/inactivation-of-ebola-virus-and-middle-east-respiratory-syndrome-coronavirus-in-platelet-concentrates-and-plasma-by-ultraviolet-c-light-and-methylene-blue-plus-visible-light-respectively
#10
Markus Eickmann, Ute Gravemann, Wiebke Handke, Frank Tolksdorf, Stefan Reichenberg, Thomas H Müller, Axel Seltsam
BACKGROUND: Ebola virus (EBOV) and Middle East respiratory syndrome coronavirus (MERS-CoV) have been identified as potential threats to blood safety. This study investigated the efficacy of the THERAFLEX UV-Platelets and THERAFLEX MB-Plasma pathogen inactivation systems to inactivate EBOV and MERS-CoV in platelet concentrates (PCs) and plasma, respectively. STUDY DESIGN AND METHODS: PCs and plasma were spiked with high titers of cell culture-derived EBOV and MERS-CoV, treated with various light doses of ultraviolet C (UVC; THERAFLEX UV-Platelets) or methylene blue (MB) plus visible light (MB/light; THERAFLEX MB-Plasma), and assessed for residual viral infectivity...
May 6, 2018: Transfusion
https://www.readbyqxmd.com/read/29717846/recognizing-and-managing-emerging-infectious-diseases-in-the-emergency-department-digest
#11
Ramón Millán, Deepti Thomas-Paulose, Daniel J Egan, Jeffrey Nusbaum, Nachi Gupta
With population shifts, increased travel, and climate change, the spread of emerging and re-emerging infections is increasing. Although encountering a patient with an emerging infection on any given emergency department shift is unlikely, missing a diagnosis could have profound consequences for the patient, healthcare workers, and the patient's close contacts. This review provides a framework to evaluate, diagnose, and treat a returning traveler with suspected Middle East respiratory syndrome, chikungunya virus, or Zika virus-3 recently emerged infections...
May 1, 2018: Emergency Medicine Practice
https://www.readbyqxmd.com/read/29716568/mers-transmission-and-risk-factors-a-systematic-review
#12
Ji-Eun Park, Soyoung Jung, Aeran Kim, Ji-Eun Park
BACKGROUND: Since Middle East respiratory syndrome (MERS) infection was first reported in 2012, many studies have analysed its transmissibility and severity. However, the methodology and results of these studies have varied, and there has been no systematic review of MERS. This study reviews the characteristics and associated risk factors of MERS. METHOD: We searched international (PubMed, ScienceDirect, Cochrane) and Korean databases (DBpia, KISS) for English- or Korean-language articles using the terms "MERS" and "Middle East respiratory syndrome"...
May 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29709903/prevention-the-spread-of-norovirus-infection-on-airborne-route-by-using-plasma-assisted-catalytic-technology-pact-device
#13
Yoshimoto Tanaka, Kan Fujino, Gerald Andrew Larkins, Atsushi Osawa, Yuji Hayashi, Satoshi Taharaguchi
Zoonosis becomes a popular word. Highly pathogenic influenza virus (HPI), Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) recently occurred at around Africa, Meddle-East and South-East Asia area, whose virus is classified as airborne. Sterilization capability was investigated by using chemical reactor of PACT device. Test on airborne infection was carried out by Feline Calicivirus Vaccine (FCV) strain F9, which is also surrogated human norovirus. It was found that PACT device could sterilize instantly FCV when passing through the plasma space of PACT device...
April 30, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29698959/lectin-affinity-plasmapheresis-for-middle-east-respiratory-syndrome-coronavirus-and-marburg-virus-glycoprotein-elimination
#14
Benjamin Koch, Patricia Schult-Dietrich, Stefan Büttner, Bijan Dilmaghani, Dario Lohmann, Patrick C Baer, Ursula Dietrich, Helmut Geiger
BACKGROUND/AIMS: Middle East respiratory syndrome coronavirus (MERS-CoV) and Marburg virus (MARV) are among the World Health Organization's top 8 emerging pathogens. Both zoonoses share nonspecific early symptoms, a high lethality rate, and a reduced number of specific treatment options. Therefore, we evaluated extracorporeal virus and glycoprotein (GP) elimination by lectin affinity plasmapheresis (LAP). METHODS: For both MERS-CoV (pseudovirus) as well as MARV (GPs), 4 LAP devices (Mini Hemopurifiers, Aethlon Medical, San Diego, CA, USA) and 4 negative controls were tested...
April 26, 2018: Blood Purification
https://www.readbyqxmd.com/read/29697919/recognizing-and-managing-emerging-infectious-diseases-in-the-emergency-department
#15
Ramón Millán, Deepti Thomas-Paulose, Daniel Egan
With population shifts, increased travel, and climate change, the spread of emerging and re-emerging infections is increasing. Although encountering a patient with an emerging infection on any given emergency department shift is unlikely, missing a diagnosis could have profound consequences for the patient, healthcare workers, and the patient's close contacts. This review provides a framework to evaluate, diagnose, and treat a returning traveler with suspected Middle East respiratory syndrome, chikungunya virus, or Zika virus-3 recently emerged infections...
May 2018: Emergency Medicine Practice
https://www.readbyqxmd.com/read/29691378/blockade-of-the-c5a-c5ar-axis-alleviates-lung-damage-in-hdpp4-transgenic-mice-infected-with-mers-cov
#16
Yuting Jiang, Guangyu Zhao, Nianping Song, Pei Li, Yuehong Chen, Yan Guo, Junfeng Li, Lanying Du, Shibo Jiang, Renfeng Guo, Shihui Sun, Yusen Zhou
The pathogenesis of highly pathogenic Middle East respiratory syndrome coronavirus (MERS-CoV) remains poorly understood. In a previous study, we established an hDPP4-transgenic (hDPP4-Tg) mouse model in which MERS-CoV infection causes severe acute respiratory failure and high mortality accompanied by an elevated secretion of cytokines and chemokines. Since excessive complement activation is an important factor that contributes to acute lung injury after viral infection, in this study, we investigated the role of complement in MERS-CoV-induced lung damage...
April 24, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29686521/knowledge-attitude-and-practice-of-secondary-schools-and-university-students-toward-middle-east-respiratory-syndrome-epidemic-in-saudi-arabia-a-cross-sectional-study
#17
Ali Al-Hazmi, Ibrahim Gosadi, Ali Somily, Sarah Alsubaie, Abdulaziz Bin Saeed
This study was aiming to investigate the knowledge, practice and attitudes of secondary school and university students toward MERS-CoV infection. This is a cross-sectional study conducted in Riyadh, Saudi Arabia. Study participants were recruited from several constituent colleges of King Saud University and secondary schools in Riyadh. Data were collected using self-administered, closed-ended questionnaires. Frequencies and proportions were computed for descriptive purposes. Chi square test was utilized to depict statistical difference between groups...
March 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29680581/middle-east-respiratory-syndrome-coronavirus-risk-factors-and-determinants-of-primary-household-and-nosocomial-transmission
#18
REVIEW
David S Hui, Esam I Azhar, Yae-Jean Kim, Ziad A Memish, Myoung-Don Oh, Alimuddin Zumla
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonosis that causes death in 35·7% of cases. As of Feb 28, 2018, 2182 cases of MERS-CoV infection (with 779 deaths) in 27 countries were reported to WHO worldwide, with most being reported in Saudi Arabia (1807 cases with 705 deaths). MERS-CoV features prominently in the WHO blueprint list of priority pathogens that threaten global health security. Although primary transmission of MERS-CoV to human beings is linked to exposure to dromedary camels (Camelus dromedarius), the exact mode by which MERS-CoV infection is acquired remains undefined...
April 18, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29672709/surveillance-of-travel-associated-diseases-at-two-referral-centres-in-marseille-france-a-12-year-survey
#19
Karolina M Griffiths, Hélène Savini, Philippe Brouqui, Fabrice Simon, Philippe Parola, Philippe Gautret
Background: With increasing international travel and historically high numbers of residents visiting friends and relatives overseas, travel-associated illnesses are frequent in Marseille, France. We report the changing epidemiology of travel-related illnesses over a 12-year period. Methods: A single site GeoSentinel surveillance analysis was undertaken for 3460 ill returned travellers presenting to two public hospitals in Marseille, France from March 2003 to October 2015, with travel-related illnesses...
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29670390/epidemiological-factors-and-worldwide-pattern-of-middle-east-respiratory-syndrome-coronavirus-from-2013-to-2016
#20
Javad Aghazadeh-Attari, Iraj Mohebbi, Behnam Mansorian, Jamal Ahmadzadeh, Mohammad Mirza-Aghazadeh-Attari, Kazhal Mobaraki, Sima Oshnouei
Background: Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging threat to global health security with high intensity and lethality. This study was conducted to investigate epidemiological factors and patterns related to this disease. Methods: Full details of MERS-CoV cases available on the disease outbreak news section of the World Health Organization official website from January 2013 to November 2016 were retrieved; demographic and clinical information, global distribution status, potential contacts, and probable risk factors for the mortality of laboratory-confirmed MERS-CoV cases were extracted and analyzed by following standard statistical methods...
2018: International Journal of General Medicine
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