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https://www.readbyqxmd.com/read/28101187/severe-pneumonia-due-to-infection-with-candida-krusei-in-a-case-of-suspected-middle-east-respiratory-syndrome-a-case-report-and-literature-review
#1
Mingming Tan, Junwei Wang, Peiyang Hu, Bin Wang, Wanghua Xu, Jiao Chen
Candida krusei (C. krusei) pneumonia is a rare infection that is frequently associated with a poor outcome. The present study reports an unusual case of C. krusei pneumonia that was initially suspected to be a Middle East respiratory syndrome (MERS) case. A 64-year-old Saudi Arabian male patient was admitted to our hospital with complaints of cough and dyspnea that persisted for 6 days. The patient presented fever (oral temperature, 38.5°C) and slight tachypnea (25 respirations/min). A chest computerized tomography demonstrated unclear lung fields, diffuse pathological changes in the two lungs and multiple lymphadenectasis in the retrocaval and para-aortic arch area...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28067571/middle-east-respiratory-syndrome-coronavirus-mers-cov-infection
#2
Reem S Almaghrabi, Ali S Omrani
Middle East respiratory syndrome coronavirus was first described in 2012. More than 1800 cases have been reported so far, the majority from countries in the Middle East region. This article outlines current understanding of the epidemiological and clinical features of Middle East respiratory syndrome coronavirus infection.
January 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28057317/factors-influencing-emergency-nurses-burnout-during-an-outbreak-of-middle-east-respiratory-syndrome-coronavirus-in-korea
#3
Ji Soo Kim, Jeong Sil Choi
PURPOSE: Emergency department (ED) nurses suffer from persistent stress after experiencing the traumatic event of exposure to Middle East respiratory syndrome coronavirus (MERS-CoV), which can subsequently lead to burnout. This study aimed to assess ED nurses' burnout level during an outbreak of MERS-CoV and to identify influencing factors in order to provide basic information for lowering and preventing the level of burnout. METHODS: Study participants were ED nurses working in eight hospitals designated for treating MERS-CoV-infected patients in Korea...
December 2016: Asian Nursing Research
https://www.readbyqxmd.com/read/28057259/modified-vaccinia-virus-ankara-history-value-in-basic-research-and-current-perspectives-for-vaccine-development
#4
REVIEW
A Volz, G Sutter
Safety tested Modified Vaccinia virus Ankara (MVA) is licensed as third-generation vaccine against smallpox and serves as a potent vector system for development of new candidate vaccines against infectious diseases and cancer. Historically, MVA was developed by serial tissue culture passage in primary chicken cells of vaccinia virus strain Ankara, and clinically used to avoid the undesirable side effects of conventional smallpox vaccination. Adapted to growth in avian cells MVA lost the ability to replicate in mammalian hosts and lacks many of the genes orthopoxviruses use to conquer their host (cell) environment...
2017: Advances in Virus Research
https://www.readbyqxmd.com/read/28056850/outbreak-of-middle-east-respiratory-syndrome-coronavirus-in-saudi-arabia-a-retrospective-study
#5
Fadilah Sfouq Aleanizy, Nahla Mohmed, Fulwah Y Alqahtani, Rania Ali El Hadi Mohamed
BACKGROUND: The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease. Dromedary camels have been implicated due to reports that some confirmed cases were exposed to camels. Risk factors for MERS coronavirus (MERS-CoV) infections in humans are incompletely understood. This study aimed to describe the demographic characteristics, mortality rate, clinical manifestations and comorbidities with confirmed cases of MERS-CoV. METHODS: Retrospective chart review were performed to identify all laboratory-confirmed cases of MERS-CoV in Saudi Arabia who reported to the Ministry of Health (MOH) of Saudi Arabia and WHO between April 23, 2014 and August 31, 2015...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28051336/social-big-data-analysis-of-information-spread-and-perceived-infection-risk-during-the-2015-middle-east-respiratory-syndrome-outbreak-in-south-korea
#6
Juyoung Song, Tae Min Song, Dong-Chul Seo, Dal-Lae Jin, Jung Sun Kim
We investigated online diffusion of information, spread of fear, and perceived risk of infection to Middle East Respiratory Syndrome (MERS) as cases of MERS spread rapidly and dozens of fatalities occurred in South Korea in May-June of 2015. This study retrieved 8,671,695 MERS-related online documents from May 20 to June 18, 2015, from 171 Korean online channels and analyzed such documents by using multilevel models and data mining with Apriori algorithm association analysis. We used R software (version 3.2...
January 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/28050021/systematic-active-surveillance-for-middle-east-respiratory-syndrome-coronavirus-in-camels-in-egypt
#7
Mohamed A Ali, Mahmoud M Shehata, Mokhtar R Gomaa, Ahmed Kandeil, Rabeh El-Shesheny, Ahmed S Kayed, Ahmed N El-Taweel, Mohamed Atea, Nagla Hassan, Ola Bagato, Yassmin Moatasim, Sara H Mahmoud, Omnia Kutkat, Asmaa M Maatouq, Ahmed Osman, Pamela P McKenzie, Richard J Webby, Ghazi Kayali
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe human infections and dromedary camels are considered an intermediary host. The dynamics of natural infection in camels are not well understood. Through systematic surveillance in Egypt, nasal, rectal, milk, urine and serum samples were collected from camels between June 2014 and February 2016. Locations included quarantines, markets, abattoirs, free-roaming herds and farmed breeding herds. The overall seroprevalence was 71% and RNA detection rate was 15%...
January 4, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28049440/an-assessment-of-the-level-of-concern-among-hospital-based-health-care-workers-regarding-mers-outbreaks-in-saudi-arabia
#8
Mostafa A Abolfotouh, Ali A AlQarni, Suliman M Al-Ghamdi, Mahmoud Salam, Mohammed H Al-Assiri, Hanan H Balkhy
BACKGROUND: Middle East Respiratory Syndrome (MERS) is caused by MERS coronavirus (MERS-CoV). More than 80% of reported cases have occurred in Saudi Arabia, with a mortality exceeding 50%. Health-care workers (HCWs) are at risk of acquiring and transmitting this virus, so the concerns of HCWs in Saudi Arabia regarding MERS were evaluated. METHODS: An anonymous, self-administered, previously validated questionnaire was given to 1031 HCWs at three tertiary hospitals in Saudi Arabia from October to December, 2014...
January 3, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28043352/current-status-and-future-direction-of-cryopreservation-of-camelid-embryos
#9
REVIEW
M Herrid, G Vajta, J A Skidmore
Over the past 3 decades, and similar to the horse industry, fresh embryo transfer has been widely practiced on large commercial scales in different camelid species, especially the dromedary camel and alpaca. However, the inability to cryopreserve embryos significantly reduces its broader application, and as such limits the capacity to utilize elite genetic resources internationally. In addition, cryopreservation of the semen of camelids is also difficult, suggesting an extreme sensitivity of the germplasm to cooling and freezing...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28040513/novel-chimeric-virus-like-particles-vaccine-displaying-mers-cov-receptor-binding-domain-induce-specific-humoral-and-cellular-immune-response-in-mice
#10
Chong Wang, Xuexing Zheng, Weiwei Gai, Gary Wong, Hualei Wang, Hongli Jin, Na Feng, Yongkun Zhao, Weijiao Zhang, Nan Li, Guoxing Zhao, Junfu Li, Jinghua Yan, Yuwei Gao, Guixue Hu, Songtao Yang, Xianzhu Xia
Middle East respiratory syndrome coronavirus (MERS-CoV) has continued spreading since its emergence in 2012 with a mortality rate of 35.6%, and is a potential pandemic threat. Prophylactics and therapies are urgently needed to address this public health problem. We report here the efficacy of a vaccine consisting of chimeric virus-like particles (VLP) expressing the receptor binding domain (RBD) of MERS-CoV. In this study, a fusion of the canine parvovirus (CPV) VP2 structural protein gene with the RBD of MERS-CoV can self-assemble into chimeric, spherical VLP (sVLP)...
December 28, 2016: Antiviral Research
https://www.readbyqxmd.com/read/28031370/binding-of-the-methyl-donor-sam-to-mers-cov-2-o-methyltransferase-nsp16-promotes-the-recruitment-of-the-allosteric-activator-nsp10
#11
Wahiba Aouadi, Alexandre Blanjoie, Jean-Jacques Vasseur, Françoise Debart, Bruno Canard, Etienne Decroly
: The Middle East respiratory syndrome coronavirus (MERS-CoV) non-structural protein 16 (nsp16) is an S-adenosyl-L-methionine (SAM)-dependent 2' -O-methyltransferase (MTase) that is thought to methylate the ribose 2' -OH of the first transcribed nucleotide (N1) of viral RNA cap structures. This 2' -O MTase activity is regulated by nsp10. The 2' -O methylation prevents virus detection by cell innate immunity mechanisms and viral translation inhibition by the interferon-stimulated IFIT-1 protein...
December 28, 2016: Journal of Virology
https://www.readbyqxmd.com/read/28018942/murine-leukemia-virus-mlv-based-coronavirus-spike-pseudotyped-particle-production-and-infection
#12
Jean Kaoru Millet, Gary R Whittaker
Viral pseudotyped particles (pp) are enveloped virus particles, typically derived from retroviruses or rhabdoviruses, that harbor heterologous envelope glycoproteins on their surface and a genome lacking essential genes. These synthetic viral particles are safer surrogates of native viruses and acquire the tropism and host entry pathway characteristics governed by the heterologous envelope glycoprotein used. They have proven to be very useful tools used in research with many applications, such as enabling the study of entry pathways of enveloped viruses and to generate effective gene-delivery vectors...
December 5, 2016: Bio-protocol
https://www.readbyqxmd.com/read/28009529/high-prevalence-of-middle-east-respiratory-coronavirus-in-young-dromedary-camels-in-jordan
#13
Neeltje van Doremalen, Zaidoun S K Hijazeen, Peter Holloway, Bilal Al Omari, Chester McDowell, Danielle Adney, Hani A Talafha, Javier Guitian, John Steel, Nadim Amarin, Markos Tibbo, Ehab Abu-Basha, Ahmad M Al-Majali, Vincent J Munster, Juergen A Richt
Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) was determined in 45 dromedary camels from two geographically separated herds in Jordan. Virus shedding was only detected in swabs obtained from the respiratory tract and primarily observed in camels younger than 3 years. MERS-CoV seroprevalence increased with age of camels. Bovine and sheep sera were seronegative. Phylogenetic analysis of partial S2 clustered the Jordanian MERS-CoV strains with contemporary MERS-CoV strains associated with nosocomial outbreaks...
December 23, 2016: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28004307/the-potential-of-social-media-and-internet-based-data-in-preventing-and-fighting-infectious-diseases-from-internet-to-twitter
#14
Khaled Al-Surimi, Mohammed Khalifa, Salwa Bahkali, Ashraf El-Metwally, Mowafa Househ
Health threats due to infectious diseases used to be a major public health concerns around the globe till mid of twentieth century when effective public health interventions helped in eradicating a number of infectious diseases around the world. Over the past 15 years, there has been a rise in the number of emerging and reemerging infectious diseases being reported such as the Acute Respiratory Syndrome (SARS) in 2002, HINI in 2009, Middle East Respiratory Syndrome (MERS) in 2012, Ebola in 2014, and Zika in 2016...
December 22, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28003490/lineage-a-betacoronavirus-ns2-proteins-and-homologous-torovirus-berne-pp1a-carboxyterminal-domain-are-phosphodiesterases-that-antagonize-activation-of-rnase-l
#15
Stephen A Goldstein, Joshua M Thornbrough, Rong Zhang, Babal K Jha, Yize Li, Ruth Elliott, Katherine Quiroz-Figueroa, Annie I Chen, Robert H Silverman, Susan R Weiss
: Viruses in the family Coronaviridae, with the Nidovirus order, are etiologic agents of a range of human and animal diseases, including both mild and severe respiratory disease in humans. These viruses encode conserved replicase and structural proteins, and more diverse accessory proteins in the 3' end of their genomes that often act as host cell antagonists. We have previously shown that 2', 5' phosphodiesterases (PDE) encoded by the prototypical Betacoronavirus, mouse hepatitis virus (MHV), Middle East respiratory syndrome-associated coronavirus antagonize the oligoadenylate - ribonuclease L (OAS-RNase L) pathway...
December 21, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27999962/human-lung-ex-vivo-infection-models
#16
REVIEW
Andreas C Hocke, Norbert Suttorp, Stefan Hippenstiel
Pneumonia is counted among the leading causes of death worldwide. Viruses, bacteria and pathogen-related molecules interact with cells present in the human alveolus by numerous, yet poorly understood ways. Traditional cell culture models little reflect the cellular composition, matrix complexity and three-dimensional architecture of the human lung. Integrative animal models suffer from species differences, which are of particular importance for the investigation of zoonotic lung diseases. The use of cultured ex vivo infected human lung tissue may overcome some of these limitations and complement traditional models...
December 20, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27999426/a-camel-derived-mers-cov-with-a-variant-spike-protein-cleavage-site-and-distinct-fusion-activation-properties
#17
Jean Kaoru Millet, Monty E Goldstein, Rachael N Labitt, Hung-Lun Hsu, Susan Daniel, Gary R Whittaker
Middle East respiratory syndrome coronavirus (MERS-CoV) continues to circulate in both humans and camels, and the origin and evolution of the virus remain unclear. Here we characterize the spike protein of a camel-derived MERS-CoV (NRCE-HKU205) identified in 2013, early in the MERS outbreak. NRCE-HKU205 spike protein has a variant cleavage motif with regard to the S2' fusion activation site-notably, a novel substitution of isoleucine for the otherwise invariant serine at the critical P1' cleavage site position...
December 21, 2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/27999424/polyphyletic-origin-of-mers-coronaviruses-and-isolation-of-a-novel-clade-a-strain-from-dromedary-camels-in-the-united-arab-emirates
#18
Susanna K P Lau, Renate Wernery, Emily Y M Wong, Sunitha Joseph, Alan K L Tsang, Nissy Annie Georgy Patteril, Shyna K Elizabeth, Kwok-Hung Chan, Rubeena Muhammed, Jöerg Kinne, Kwok-Yung Yuen, Ulrich Wernery, Patrick C Y Woo
Little is known regarding the molecular epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) circulating in dromedaries outside Saudi Arabia. To address this knowledge gap, we sequenced 10 complete genomes of MERS-CoVs isolated from 2 live and 8 dead dromedaries from different regions in the United Arab Emirates (UAE). Phylogenetic analysis revealed one novel clade A strain, the first detected in the UAE, and nine clade B strains. Strain D998/15 had a distinct phylogenetic position within clade A, being more closely related to the dromedary isolate NRCE-HKU205 from Egypt than to the human isolates EMC/2012 and Jordan-N3/2012...
December 21, 2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/27997933/from-plague-to-mers-coordinating-australia-s-response-to-emerging-infectious-diseases
#19
Jenny Firman, Stephanie A Williams, Chris Baggoley
Rapid international travel times and the arrival of new and unexpected infectious disease threats have demonstrated that, for effective communicable disease control, Australia's response needs to be flexible and coordinated. This paper summarises how our public health and clinical systems would respond to a case of Middle East respiratory syndrome (MERS) coronavirus and our responsibility under the International Health Regulations to notify the World Health Organization (WHO). It also describes the processes undertaken by WHO when it declares that a disease outbreak is a Public Health Emergency of International Concern...
December 14, 2016: Public Health Research & Practice
https://www.readbyqxmd.com/read/27989237/modernising-epidemic-science-enabling-patient-centred-research-during-epidemics
#20
EDITORIAL
Amanda M Rojek, Peter W Horby
BACKGROUND: Emerging and epidemic infectious disease outbreaks are a significant public health problem and global health security threat. As an outbreak begins, epidemiological investigations and traditional public health responses are generally mounted very quickly. However, patient-centred research is usually not prioritised when planning and enacting the response. Instead, the clinical research response occurs subsequent to and separate from the public health response, and is inadequate for evidence-based decision-making at the bedside or in the offices of public health policymakers...
December 19, 2016: BMC Medicine
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