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https://www.readbyqxmd.com/read/28636980/a-multiplex-liquid-chip-assay-based-on-luminex-xmap-technology-for-simultaneous-detection-of-six-common-respiratory-viruses
#1
Yong Yan, Jian-Yong Luo, Yin Chen, Heng-Hui Wang, Guo-Ying Zhu, Pei-Yan He, Jin-Lei Guo, Yong-Liang Lei, Zhong-Wen Chen
We utilized one-step multiplex reverse transcription-PCR (RT-PCR) and Luminex xMAP technology to develop a respiratory multiplex liquid-chip assay (rMLA) for simultaneous detection of 6 common respiratory viruses, including influenza virus type A (FluA) and type B (FluB), para-influenza virus type 3 (PIV-3), respiratory syncytial virus (RSV), human metapneumovirus (MPV) and a threatening virus to China, Middle East Respiratory Syndrome coronavirus (MERS-CoV). Performance of rMLA was evaluated by comparing with real-time RT-PCR...
June 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28634355/longitudinal-study-of-middle-east-respiratory-syndrome-coronavirus-infection-in-dromedary-camel-herds-in-saudi-arabia-2014-2015
#2
Maged Gomaa Hemida, Abdulmohsen Alnaeem, Daniel Kw Chu, Ranawaka Apm Perera, Samuel Ms Chan, Faisal Almathen, Emily Yau, Brian Cy Ng, Richard J Webby, Leo Lm Poon, Malik Peiris
Two herds of dromedary camels were longitudinally sampled with nasal and rectal swabs and serum, between September 2014 and May 2015, and the samples were tested for Middle East Respiratory Syndrome (MERS) coronavirus RNA and antibodies. Evidence of MERS-CoV infection was confirmed in one herd on the basis of detection of virus RNA in nasal swabs from three camels and significant increases in the antibody titers from three others. The three viruses were genetically identical, thus indicating introduction of a single virus into this herd...
June 21, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28630747/global-patterns-in-coronavirus-diversity
#3
Simon J Anthony, Christine K Johnson, Denise J Greig, Sarah Kramer, Xiaoyu Che, Heather Wells, Allison L Hicks, Damien O Joly, Nathan D Wolfe, Peter Daszak, William Karesh, W I Lipkin, Stephen S Morse, Jonna A K Mazet, Tracey Goldstein
Since the emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrom Coronavirus (MERS-CoV) it has become increasingly clear that bats are important reservoirs of CoVs. Despite this, only 6% of all CoV sequences in GenBank are from bats. The remaining 94% largely consist of known pathogens of public health or agricultural significance, indicating that current research effort is heavily biased towards describing known diseases rather than the 'pre-emergent' diversity in bats...
January 2017: Virus Evolution
https://www.readbyqxmd.com/read/28625842/dynamics-of-scientific-publications-on-the-mers-cov-outbreaks-in-saudi-arabia
#4
REVIEW
Ali Rabaan, Shamsah H Al-Ahmed, Ali M Bazzi, Jaffar A Al-Tawfiq
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an emerging disease with a relatively high case fatality rate. Most cases have been reported from Saudi Arabia, and the disease epidemic potential is considered to be limited. However, human-human transmission has occurred, usually in the context of healthcare facility-associated outbreaks. The scientific and medical community depends on timely publication of epidemiological information on emerging diseases during outbreaks to appropriately target public health responses...
June 15, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28616502/dromedary-camels-in-northern-mali-have-high-seropositivity-to-mers-cov
#5
Darryl Falzarano, Badian Kamissoko, Emmie de Wit, Ousmane Maïga, Jacqueline Cronin, Kassim Samaké, Abdalah Traoré, Shauna Milne-Price, Vincent J Munster, Nafomon Sogoba, Mamadou Niang, David Safronetz, Heinz Feldmann
A high percentage (up to 90%) of dromedary camels in the Middle East as well as eastern and central Africa have antibodies to Middle East respiratory syndrome coronavirus (MERS-CoV). Here we report comparably high positivity of MERS-CoV antibodies in dromedary camels from northern Mali. This extends the range of MERS-CoV further west in Africa than reported to date and cautions that MERS-CoV should be considered in cases of severe respiratory disease in the region.
June 2017: One Health
https://www.readbyqxmd.com/read/28616501/searching-for-animal-models-and-potential-target-species-for-emerging-pathogens-experience-gained-from-middle-east-respiratory-syndrome-mers-coronavirus
#6
REVIEW
Júlia Vergara-Alert, Enric Vidal, Albert Bensaid, Joaquim Segalés
Emerging and re-emerging pathogens represent a substantial threat to public health, as demonstrated with numerous outbreaks over the past years, including the 2013-2016 outbreak of Ebola virus in western Africa. Coronaviruses are also a threat for humans, as evidenced in 2002/2003 with infection by the severe acute respiratory syndrome coronavirus (SARS-CoV), which caused more than 8000 human infections with 10% fatality rate in 37 countries. Ten years later, a novel human coronavirus (Middle East respiratory syndrome coronavirus, MERS-CoV), associated with severe pneumonia, arose in the Kingdom of Saudi Arabia...
June 2017: One Health
https://www.readbyqxmd.com/read/28616497/mers-coronavirus-from-discovery-to-intervention
#7
REVIEW
W Widagdo, Nisreen M A Okba, V Stalin Raj, Bart L Haagmans
Middle East respiratory syndrome coronavirus (MERS-CoV) still causes outbreaks despite public awareness and implementation of health care measures, such as rapid viral diagnosis and patient quarantine. Here we describe the current epidemiological picture of MERS-CoV, focusing on humans and animals affected by this virus and propose specific intervention strategies that would be appropriate to control MERS-CoV. One-third of MERS-CoV patients develop severe lower respiratory tract infection and succumb to a fatal outcome; these patients would require effective therapeutic antiviral therapy...
June 2017: One Health
https://www.readbyqxmd.com/read/28613145/two-novel-dromedary-camel-bocaparvoviruses-from-dromedaries-in-the-middle-east-with-unique-genomic-features
#8
Patrick C Y Woo, Susanna K P Lau, Hoi-Wah Tsoi, Nissy Georgy Patteril, Hazel C Yeung, Sunitha Joseph, Emily Y M Wong, Rubeena Muhammed, Franklin W N Chow, Ulrich Wernery, Kwok-Yung Yuen
The recent emergence of Middle East respiratory syndrome (MERS) coronavirus and its discovery from dromedary camels has boosted interest in the search for novel viruses in dromedaries. While bocaparvoviruses are known to infect various animals, it was not known that they exist in dromedaries. In this study, we describe the discovery of two novel dromedary camel bocaparvoviruses (DBoVs), DBoV1 and DBoV2, from dromedary faecal samples in Dubai. Among 667 adult dromedaries and 72 dromedary calves, 13.9 % of adult dromedaries and 33...
June 14, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28610609/estimation-of-basic-reproduction-number-of-the-middle-east-respiratory-syndrome-coronavirus-mers-cov-during-the-outbreak-in-south-korea-2015
#9
Hyuk-Jun Chang
BACKGROUND: In South Korea, an outbreak of Middle East respiratory syndrome (MERS) occurred in 2015. It was the second largest MERS outbreak. As a result of the outbreak in South Korea, 186 infections were reported, and 36 patients died. At least 16,693 people were isolated with suspicious symptoms. This paper estimates the basic reproduction number of the MERS coronavirus (CoV), using data on the spread of MERS in South Korea. METHODS: The basic reproduction number of an epidemic is defined as the average number of secondary cases that an infected subject produces over its infectious period in a susceptible and uninfected population...
June 13, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28608547/computational-modeling-of-the-bat-hku4-coronavirus-3cl-pro-inhibitors-as-a-tool-for-the-development-of-antivirals-against-the-emerging-middle-east-respiratory-syndrome-mers-coronavirus
#10
Areej Abuhammad, Rua'a A Al-Aqtash, Brandon J Anson, Andrew D Mesecar, Mutasem O Taha
The Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus that poses a major challenge to clinical management. The 3C-like protease (3CL(pro) ) is essential for viral replication and thus represents a potential target for antiviral drug development. Presently, very few data are available on MERS-CoV 3CL(pro) inhibition by small molecules. We conducted extensive exploration of the pharmacophoric space of a recently identified set of peptidomimetic inhibitors of the bat HKU4-CoV 3CL(pro) ...
June 13, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28588290/comparative-epidemiology-of-middle-east-respiratory-syndrome-coronavirus-mers-cov-in-saudi-arabia-and-south-korea
#11
Xin Chen, Abrar Ahmad Chughtai, Amalie Dyda, Chandini Raina MacIntyre
MERS-CoV infection emerged in the Kingdom of Saudi Arabia (KSA) in 2012 and has spread to 26 countries. However, 80% of all cases have occurred in KSA. The largest outbreak outside KSA occurred in South Korea (SK) in 2015. In this report, we describe an epidemiological comparison of the two outbreaks. Data from 1299 cases in KSA (2012-2015) and 186 cases in SK (2015) were collected from publicly available resources, including FluTrackers, the World Health Organization (WHO) outbreak news and the Saudi MOH (MOH)...
June 7, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28585916/mers-cov-antibody-responses-1-year-after-symptom-onset-south-korea-2015
#12
Pyoeng Gyun Choe, R A P M Perera, Wan Beom Park, Kyoung-Ho Song, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Long Wei Ronald Ko, Sang Won Park, Nam-Joong Kim, Eric H Y Lau, Leo L M Poon, Malik Peiris, Myoung-Don Oh
We investigated the kinetics of the Middle East respiratory syndrome coronavirus (MERS-CoV) neutralizing and spike protein antibody titers over the course of 1 year in 11 patients who were confirmed by reverse transcription PCR to have been infected during the outbreak in South Korea in 2015. Robust antibody responses were detected in all survivors who had severe disease; responses remained detectable, albeit with some waning, for <1 year. The duration of viral RNA detection (but not viral load) in sputum significantly correlated with the antibody response magnitude...
July 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28579232/chadox1-and-mva-based-vaccine-candidates-against-mers-cov-elicit-neutralising-antibodies-and-cellular-immune-responses-in-mice
#13
Naif Khalaf Alharbi, Eriko Padron-Regalado, Craig P Thompson, Alexandra Kupke, Daniel Wells, Megan A Sloan, Keith Grehan, Nigel Temperton, Teresa Lambe, George Warimwe, Stephan Becker, Adrian V S Hill, Sarah C Gilbert
The Middle East respiratory syndrome coronavirus (MERS-CoV) has infected more than 1900 humans, since 2012. The syndrome ranges from asymptomatic and mild cases to severe pneumonia and death. The virus is believed to be circulating in dromedary camels without notable symptoms since the 1980s. Therefore, dromedary camels are considered the only animal source of infection. Neither antiviral drugs nor vaccines are approved for veterinary or medical use despite active research on this area. Here, we developed four vaccine candidates against MERS-CoV based on ChAdOx1 and MVA viral vectors, two candidates per vector...
June 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28576573/rapid-development-of-vaccines-against-emerging-pathogens-the-replication-deficient-simian-adenovirus-platform-technology
#14
Sarah C Gilbert, George M Warimwe
Despite the fact that there had been multiple small outbreaks of Ebola Virus Disease, when a large outbreak occurred in 2014 there were no vaccines or drugs available for use. Clinical development of multiple candidate vaccines was then initiated in parallel with attempts to contain the outbreak but only one vaccine was eventually tested in a phase III trial. In order to be better prepared for future outbreaks of known human pathogens, platform technologies to accelerate vaccine development should be employed, allowing vaccine developers to take advantage of detailed knowledge of the vaccine platform and facilitating rapid progress to clinical trials and eventually to vaccine stockpiles...
May 30, 2017: Vaccine
https://www.readbyqxmd.com/read/28575307/identified-transmission-dynamics-of-middle-east-respiratory-syndrome-coronavirus-infection-during-an-outbreak-implications-of-an-overcrowded-emergency-department
#15
Thamer H Alenazi, Hussain Al Arbash, Aiman El-Saed, Majid M Alshamrani, Henry Baffoe-Bonnie, Yaseen M Arabi, Sameera M Al Johani, Ra'ed Hijazi, Adel Alothman, Hanan H Balkhy
A total 130 cases of Middle East respiratory syndrome coronavirus were identified during a large hospital outbreak in Saudi Arabia; 87 patients and 43 healthcare workers. The majority (80%) of transmission was healthcare-acquired (HAI) infection, with 4 generations of HAI transmission. The emergency department was the main location of exposure.
May 31, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28574363/analysis-of-the-genome-sequence-and-prediction-of-b-cell-epitopes-of-the-envelope-protein-of-middle-east-respiratory-syndrome-coronavirus
#16
Qian Xie, Xiaoyan He, Fangji Yang, Xuling Liu, Ying Li, Yujing Liu, ZhengMeng Yang, Jianhai Yu, Bao Zhang, Wei Zhao
The outbreak of Middle East respiratory syndrome-coronavirus (MERS-CoV) in South Korea in April 2015 led to 186 infections and 37 deaths by the end of October 2015. MERS-CoV was isolated from the imported patient in China. The envelope (E) protein, a small structural protein of MERS-CoV, plays an important role in host recognition and infection. To identify the conserved epitopes of the E protein, sequence analysis was performed by comparing the E proteins from 42 MERS-CoV strains that triggered severe pandemics and infected humans in the past...
May 29, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28566972/to-what-extent-are-arab-pilgrims-to-makkah-aware-of-the-middle-east-respiratory-syndrome-coronavirus-and-the-precautions-against-it
#17
Meshaal S Alotaibi, Abdulaziz M Alsubaie, Khaled A Almohaimede, Turki A Alotaibi, Omar A Alharbi, Abdulrahman F Aljadoa, Abdulaziz H Alhamad, Mazin Barry
BACKGROUND: Approximately, 80% of the many cases of the Middle East respiratory syndrome coronavirus (MERS-CoV) confirmed worldwide were diagnosed in the Kingdom of Saudi Arabia (KSA). The risk of the disease spreading internationally is especially worrying given the role of KSA as the home of the most important Islamic pilgrimage sites. This means the need to assess Arab pilgrims' awareness of MERS-CoV is of paramount importance. MATERIALS AND METHODS: A cross-sectional study was carried out during Ramadan 2015 in the Holy Mosque in Makkah, Saudi Arabia...
May 2017: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/28566313/evaluation-of-a-real-time-rt-pcr-assay-for-detection-of-mers-cov-in-clinical-samples-from-an-outbreak-in-south-korea-2015
#18
Jee-Soo Lee, Ji Soo Ahn, Byeong Su Yu, Sung Im Cho, Man Jin Kim, Jong Moon Choi, Soo Hyun Seo, Sung Sup Park, Moon-Woo Seong
In the period from September 2012 to April 2017, 1,936 laboratory-confirmed Middle East respiratory syndrome coronavirus (MERS-CoV) cases, including 690 mortalities, were reported from 27 countries (http://www.who.int/emergencies/mers-cov/en/).….
May 31, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28542609/potent-and-selective-inhibition-of-pathogenic-viruses-by-engineered-ubiquitin-variants
#19
Wei Zhang, Ben A Bailey-Elkin, Robert C M Knaap, Baldeep Khare, Tim J Dalebout, Garrett G Johnson, Puck B van Kasteren, Nigel J McLeish, Jun Gu, Wenguang He, Marjolein Kikkert, Brian L Mark, Sachdev S Sidhu
The recent Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola and Zika virus outbreaks exemplify the continued threat of (re-)emerging viruses to human health, and our inability to rapidly develop effective therapeutic countermeasures. Many viruses, including MERS-CoV and the Crimean-Congo hemorrhagic fever virus (CCHFV) encode deubiquitinating (DUB) enzymes that are critical for viral replication and pathogenicity. They bind and remove ubiquitin (Ub) and interferon stimulated gene 15 (ISG15) from cellular proteins to suppress host antiviral innate immune responses...
May 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28536429/a-novel-neutralizing-monoclonal-antibody-targeting-the-n-terminal-domain-of-the-mers-cov-spike-protein
#20
Yingzhu Chen, Shuai Lu, Hao Jia, Yao Deng, Jianfang Zhou, Baoying Huang, Yueyang Yu, Jiaming Lan, Wenling Wang, Yongliang Lou, Kun Qin, Wenjie Tan
Middle East respiratory syndrome coronavirus (MERS-CoV) has caused fatal infections, some through hospital-acquired transmission, in affected regions since its emergence in 2012. Although the virus is not pandemic among humans, it poses a great threat to public health due to its zoonotic origin. Thus, both preventative and therapeutic countermeasures are urgently needed. In this study, we discovered a panel of neutralizing monoclonal antibodies (mAbs) against MERS-CoV, which mapped to a wide range of regions on the spike (S) protein of the virus...
May 24, 2017: Emerging Microbes & Infections
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