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https://www.readbyqxmd.com/read/29773416/the-association-between-egfr-in-the-normal-or-mildly-impaired-range-and-incident-cadiovascular-disease-age-and-sex-analysis
#1
Alon Eisen, Avital Porter, Moshe Hoshen, Ran D Balicer, Orna Reges, Yardena Rabi, Morton Leibowitz, Zaza Iakobishvili, David Hasdai
BACKGROUND: Worse renal function, even in the normal or mildly impaired range, is associated with incident cardiovascular disease (CVD). Whether this association exists in both sexes across all ages is not known. METHODS: A population based cohort of individuals >22 years with no prior CVD and with an eGFR 60-130 ml/min/1.73 m2 . eGFR was calculated using the CKD-EPI formula. Incident CVD was defined as either myocardial infarction, unstable angina pectoris, coronary revascularization, or cerebrovascular event...
May 14, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29764706/atrial-fibrillation-and-ischemic-events-with-rivaroxaban-in-patients-with-stable-coronary-artery-disease-afire-protocol-for-a-multicenter-prospective-randomized-open-label-parallel-group-study
#2
Satoshi Yasuda, Koichi Kaikita, Hisao Ogawa, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui
BACKGROUND: In atrial fibrillation (AF) patients with coronary artery disease (CAD), anticoagulants are commonly used in combination with antiplatelet drugs. However, dual therapy can increase the risk of bleeding, and the potential therapeutic benefits must be weighed against this. Therefore, it is recommended that dual therapy is only used for a limited time, and that monotherapy with anticoagulants should start from 1 year after percutaneous coronary intervention (PCI). However, there is a lack of evidence on the use of monotherapy, in particular with direct oral anticoagulants, in this group of patients...
May 2, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29754663/the-prognostic-value-of-the-relationship-between-right-atrial-and-pulmonary-capillary-wedge-pressure-in-diverse-cardiovascular-conditions
#3
Douglas Marshall Brinkley, Kalon K L Ho, Mark H Drazner, Robb D Kociol
BACKGROUND: Physical examination of jugular venous pressure is used to estimate right atrial (RA) pressure and infer left-sided filling pressure to assist volume management. Previous studies in advanced heart failure patients showed about 75% concordance between RA and pulmonary capillary wedge (PCW) pressures. We sought to determine the relationship between mean RA and mean PCW pressure and assess the clinical significance in a broad population of patients undergoing invasive right heart catheterization (RHC)...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29754655/characteristics-and-long-term-outcomes-of-patients-with-acute-coronary-syndromes-due-to-culprit-left-main-coronary-artery-disease-treated-with-percutaneous-coronary-intervention
#4
S Michael Gharacholou, Nkechinyere N Ijioma, Ryan J Lennon, Charanjit S Rihal, Malcolm R Bell, Jorge A Brenes-Salazar, Gurpreet S Sandhu, Rajiv Gulati, Patricia A Pellikka, Peter M Pollak, Gary E Lane, Dilip P Pillai, Freddy Del-Carpio Munoz, Arashk Motiei, Mandeep Singh
BACKGROUND: Patients with acute coronary syndrome (ACS) due to unprotected culprit left main coronary artery disease (LMCAD) treated with percutaneous coronary intervention (PCI) are rare, high-risk, and not represented in trials. Data regarding long term outcome after PCI are limited. METHODS: Between January 2000 and December 2014, there were 8,794 patients hospitalized with unstable angina/non-ST elevation myocardial infarction (UA/NSTEMI) or ST-elevation myocardial infarction (STEMI) treated with PCI at our institution; of these, 83 (0...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29753395/quantitative-extent-of-atherosclerotic-plaque-in-the-major-epicardial-coronary-arteries-in-patients-with-fatal-coronary-heart-disease-in-coronary-endarterectomy-specimens-in-aorta-coronary-saphenous-venous-conduits-and-means-to-prevent-the-plaques-a-review
#5
William C Roberts
This review tries to answer the following 15 questions: Is atherosclerosis a systemic or a regional disease? Is atherosclerosis in any particular region focal or diffuse? What is the quantity of atherosclerotic plaques in endarterectomy specimens of the right coronary artery in patients undergoing coronary artery bypass grafting (CABG) compared to that in the right coronary artery in patients with fatal coronary artery disease? How do the units used for measuring arterial narrowing by angiography compare to the units used for measuring arterial narrowing at necropsy? What do atherosclerotic plaques consist of in coronary arteries in patients with fatal coronary disease? What is the quantity of atherosclerotic plaque in bypassed -vs- non-bypassed native coronary arteries in patients dying early (<60 days) or late (>60 days) after coronary artery bypass grafting? What is the frequency of acute coronary lesions and multi-luminal channels at necropsy in patients with unstable angina pectoris, sudden coronary death, and acute myocardial infarction? What is the mechanism of luminal widening by angioplasty in the coronary arteries? What observations suggest that atherosclerotic plaques are the result at least in part of organization of thrombi? Is atherosclerosis a multifactoral or a unifactoral disease? What characteristics distinguish carnivores and herbivores? What are reasonable guidelines for whom to treat with lipid-altering agents? What is the rule of 5 and the rule of 7 in statin therapy? What is the effect of lipid lowering drug therapy on coronary luminal narrowing? What are some requisites for a healthy life?...
March 27, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29742921/long-term-prognostic-value-of-coronary-computed-tomography-angiography-in-chest-pain-patients
#6
Mårten Sandstedt, Jakob De Geer, Lilian Henriksson, Jan Engvall, Magnus Janzon, Anders Persson, Joakim Alfredsson
Background Coronary computed tomography angiography (CCTA) is increasingly used to detect coronary artery disease (CAD), but long-term follow-up studies are still scarce. Purpose To evaluate the prognostic value of CCTA in patients with suspected CAD. Material and Methods A total of 1205 consecutive CCTA patients with chest pain were classified as normal coronary arteries, non-obstructive CAD, or obstructive CAD. The primary outcome was major adverse cardiac event (MACE), defined as a composite outcome including cardiac death, myocardial infarction, unstable angina pectoris, or late revascularization (after >90 days)...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29736064/psychiatric-comorbidities-in-acute-coronary-syndromes-six-month-follow-up-study
#7
D Ramya Shruthi, S Sunil Kumar, Nagaraj Desai, Rajesh Raman, T S Sathyanarayana Rao
Introduction: Acute coronary syndrome (ACS) caused by coronary atherosclerosis include ST-segment elevation myocardial infarction (STEMI), non-STEMI, and unstable angina. The relation between psychiatric disorders and coronary artery disease is a complex one which includes the effect of the psychosocial factors on heart and vice versa. Point prevalence studies have been reported, but there is paucity of follow-up studies from India. Materials and Methods: The study is a follow-up evaluation at discharge of 248 consecutive patients presented with ACS at JSS Hospital, Mysuru, Karnataka, over a period of 6 months to assess the psychiatric comorbidities...
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29735587/high-dose-versus-low-dose-pitavastatin-in-japanese-patients-with-stable-coronary-artery-disease-real-cad-a-randomized-superiority-trial
#8
Isao Taguchi, Satoshi Iimuro, Hiroshi Iwata, Hiroaki Takashima, Mitsuru Abe, Eisuke Amiya, Takanori Ogawa, Yukio Ozaki, Ichiro Sakuma, Yoshihisa Nakagawa, Kiyoshi Hibi, Takafumi Hiro, Yoshihiro Fukumoto, Seiji Hokimoto, Katsumi Miyauchi, Tsutomu Yamazaki, Hiroshi Ito, Yutaka Otsuji, Kazuo Kimura, Jun Takahashi, Atsushi Hirayama, Hiroyoshi Yokoi, Kazuo Kitagawa, Takao Urabe, Yasushi Okada, Yasuo Terayama, Kazunori Toyoda, Takehiko Nagao, Masayasu Matsumoto, Yasuo Ohashi, Tetsuji Kaneko, Retsu Fujita, Hiroshi Ohtsu, Hisao Ogawa, Hiroyuki Daida, Hiroaki Shimokawa, Yasushi Saito, Takeshi Kimura, Teruo Inoue, Masunori Matsuzaki, Ryozo Nagai
BACKGROUND: Current guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous "more versus less statins" trials. However, no clear evidence for more versus less statins has been established in an Asian population. METHODS: In this prospective, multicenter, randomized, open-label, blinded end point study, 13 054 Japanese patients with stable coronary artery disease who achieved low-density lipoprotein cholesterol (LDL-C) <120 mg/dL during a run-in period (pitavastatin 1 mg/d) were randomized in a 1-to-1 fashion to high-dose (pitavastatin 4 mg/d; n=6526) or low-dose (pitavastatin 1 mg/d; n=6528) statin therapy...
May 8, 2018: Circulation
https://www.readbyqxmd.com/read/29721664/echocardiographic-measurements-of-epicardial-adipose-tissue-and-comparative-ability-to-predict-adverse-cardiovascular-outcomes-in-patients-with-coronary-artery-disease
#9
Julieta D Morales-Portano, Juan Ángel Peraza-Zaldivar, Juan A Suárez-Cuenca, Rocío Aceves-Millán, Lilia Amezcua-Gómez, Carlos H Ixcamparij-Rosales, Rafael Trujillo-Cortés, Rogelio Robledo-Nolasco, Paul Mondragón-Terán, Rebeca Pérez-Cabeza de Vaca, Rolando Hernández-Muñoz, Alberto Melchor-López, Mani A Vannan, Alberto Francisco Rubio-Guerra
The present study aimed to compare echocardiography measurements of epicardial adipose tissue (EAT) thickness and other risk factors regarding their ability to predict adverse cardiovascular outcomes in patients with coronary artery disease (CAD). Outcomes of 107 patients (86 males, 21 females, mean age 63.6 years old) submitted to diagnostic echocardiography and coronary angiography were prospectively analyzed. EAT (measures over the right ventricle, interventricular groove and complete bulk of EAT) and left ventricle ejection fraction (LVEF) were performed by echocardiography...
May 2, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29720503/clinical-characteristics-sex-differences-and-outcomes-in-patients-with-normal-or-near-normal-coronary-arteries-non-obstructive-or-obstructive-coronary-artery-disease
#10
Michelle L Ouellette, Adrián I Löffler, George A Beller, Virginia K Workman, Eric Holland, Jamieson M Bourque
BACKGROUND: Normal or near-normal coronary arteries (NNCAs) or nonobstructive coronary artery disease (CAD) are found on invasive coronary angiography in ≈55% of patients. Some attribute this to frequent referral of low-risk patients. We sought to identify the referral indications, pretest risk, key clinical characteristics, sex, and outcomes in patients with NNCAs and nonobstructive CAD versus obstructive CAD on nonemergent invasive coronary angiography. METHODS AND RESULTS: Over 24 months, 925 consecutive patients were classified as having NNCAs (≤20% stenosis), nonobstructive CAD (21-49% stenosis), or obstructive CAD (≥50% stenosis)...
May 2, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29717283/utility-of-ischemia-modified-albumin-as-an-early-marker-for-diagnosis-of-acute-coronary-syndrome
#11
Bijaya Mishra, Sunil Pandey, Surya Raj Niraula, Bijendra Kumar Rai, Prahlad Karki, Nirmal Baral, Madhab Lamsal
BACKGROUND: The diagnosis of acute coronary syndrome remains challenging, as cardiac troponins and creatine kinase-MB do not detect myocardial ischemia. Ischemia modified albumin is biomarker positive within 6-10 minutes following ischemic onset, where oxygen free radicals leads to reduction in binding capacity of human serum albumin to transitional metal-cobalt. The objective of this study was to compare ischemia modified albumin between acute coronary syndrome patients and healthy controls, and evaluate diagnostic performance of ischemia modified albumin compared to cardiac troponins, creatine kinase-MB and electrocardiogram in acute coronary syndrome patients...
March 13, 2018: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/29716940/residual-inflammatory-risk-on-treatment-with-pcsk9-inhibition-and-statin-therapy
#12
Aruna D Pradhan, Aaron W Aday, Lynda M Rose, Paul M Ridker
Background -The combination of statin therapy and proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibition markedly lowers low-density lipoprotein cholesterol (LDL-C) and reduces cardiovascular event rates. Whether residual inflammatory risk as measured by on-treatment high sensitivity C-reactive protein (hsCRP) remains an important clinical issue in such patients is uncertain. Methods -We evaluated residual inflammatory risk among 9,738 patients participating in the Studies of PCSK9 Inhibition and the Reduction of Vascular Events (SPIRE)-1 and -2 cardiovascular outcomes trials who were receiving both statin therapy and bococizumab, according to on-treatment levels of hsCRP (hsCRPOT ) and LDL-COT measured 14 weeks after drug initiation...
May 1, 2018: Circulation
https://www.readbyqxmd.com/read/29701358/carotid-stenosis-in-cardiac-surgery-patients
#13
Pedro Pinto Sousa, Gabriela Teixeira, João Gonçalves, Carlos Veiga, Pedro Sá Pinto, Pedro Brandão, Alexandra Canedo, Luis Vouga, Rui Almeida
INTRODUCTION: Ischemic stroke is a potential perioperative complication after an open heart surgery (OHS). Whether a carotid stenosis or occlusion is associated with an increased risk of perioperative stroke in patients or just a risk factor has been a concern of intense debate in the literature. METHODS: We retrospectively analyzed patients submitted to OHS between January and December2016 with known asymptomatic carotid disease. The data from 85 consecutive patients undergoing coronary artery bypass grafting, valve replacement, or both was collected...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29691803/association-of-beta-blockers-with-survival-on-patients-presenting-with-acs-treated-with-pci-a-propensity-score-analysis-from-the-bleemacs-registry
#14
Fabrizio D'Ascenzo, Dario Celentani, Alessandro Brustio, Alberto Grosso, Sergio Raposeiras-Roubín, Emad Abu-Assi, Jose Paulo Simao Henriques, Jorge Saucedo, José Ramón González-Juanatey, Stephen B Wilton, Wouter J Kikkert, Iván Nuñez-Gil, Albert Ariza-Sole, Xiantao Song, Dimitrios Alexopoulos, Christoph Liebetrau, Tetsuma Kawaji, Zenon Huczek, Shao-Ping Nie, Toshiharu Fujii, Luis Correia, Masa-Aki Kawashiri, José María García-Acuña, Danielle Southern, Emilio Alfonso, Belén Terol, Alberto Garay, Dongfeng Zhang, Yalei Chen, Ioanna Xanthopoulou, Neriman Osman, Helge Möllmann, Hiroki Shiomi, Michal Kowara, Krzysztof Filipiak, Xiao Wang, Yan Yan, Jing-Yao Fan, Yuji Ikari, Takuya Nakahayshi, Kenji Sakata, Masakazu Yamagishi, Oliver Kalpak, Sasko Kedev, Claudio Moretti, Maurizio D'Amico, Fiorenzo Gaita
PURPOSE: The aim was to evaluate prognostic value of beta-blocker (BB) administration in acute coronary syndromes (ACS) patients in the percutaneous coronary intervention (PCI) era. METHODS AND RESULTS: The BleeMACS project is a multicenter, observational, retrospective registry enrolling patients with ACS worldwide in 15 hospitals. Patients discharged with BB therapy were compared to those discharged without a BB before and after propensity score with matching...
April 24, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29686027/10-year-associations-between-tumor-necrosis-factor-receptors-1-and-2-and-cardiovascular-events-in-patients-with-stable-coronary-heart-disease-a-claricor-effect-of-clarithromycin-on-mortality-and-morbidity-in-patients-with-ischemic-heart-disease-trial-substudy
#15
Axel C Carlsson, Toralph Ruge, Erik Kjøller, Jørgen Hilden, Hans Jørn Kolmos, Ahmad Sajadieh, Jens Kastrup, Gorm Boje Jensen, Anders Larsson, Christoph Nowak, Janus Christian Jakobsen, Per Winkel, Christian Gluud, Johan Ärnlöv
BACKGROUND: We aimed to assess the associations and predictive powers between the soluble receptors for tumor necrosis factor (TNF)-α (TNFR1 and TNFR2) and cardiovascular outcomes in patients with stable coronary heart disease. METHODS AND RESULTS: CLARICOR (Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease) is a randomized clinical trial comparing clarithromycin with placebo in patients with stable coronary heart disease...
April 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29677303/association-between-use-of-sodium-glucose-cotransporter-2-inhibitors-glucagon-like-peptide-1-agonists-and-dipeptidyl-peptidase-4-inhibitors-with-all-cause-mortality-in-patients-with-type-2-diabetes-a-systematic-review-and-meta-analysis
#16
REVIEW
Sean L Zheng, Alistair J Roddick, Rochan Aghar-Jaffar, Matthew J Shun-Shin, Darrel Francis, Nick Oliver, Karim Meeran
Importance: The comparative clinical efficacy of sodium-glucose cotransporter 2 (SGLT-2) inhibitors, glucagon-like peptide 1 (GLP-1) agonists, and dipeptidyl peptidase 4 (DPP-4) inhibitors for treatment of type 2 diabetes is unknown. Objective: To compare the efficacies of SGLT-2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors on mortality and cardiovascular end points using network meta-analysis. Data Sources: MEDLINE, Embase, Cochrane Library Central Register of Controlled Trials, and published meta-analyses from inception through October 11, 2017...
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29669424/impact-of-chronic-antiplatelet-therapy-on-infarct-size-and-bleeding-in-patients-with-acute-myocardial-infarction
#17
Jeness Campodonico, Nicola Cosentino, Valentina Milazzo, Mara Rubino, Monica De Metrio, Ivana Marana, Marco Moltrasio, Marco Grazi, Gianfranco Lauri, Alice Bonomi, Fabrizio Veglia, Elisa Chiorino, Emilio Assanelli, Antonio L Bartorelli, Giancarlo Marenzi
BACKGROUND: Patients hospitalized with acute myocardial infarction (AMI) are often on prior single antiplatelet therapy (SAPT) or a dual antiplatelet therapy (DAPT). Whether chronic SAPT or DAPT is beneficial or associated with an increased risk in AMI is still controversial. METHODS AND RESULTS: We prospectively enrolled 1718 consecutive patients with AMI (798 ST-segment elevation myocardial infarction and 920 non-ST-segment elevation myocardial infarction) who were divided according to their chronic APT (no APT, SAPT, or DAPT)...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29664423/long-term-follow-up-of-antithrombotic-management-patterns-in-acute-coronary-syndrome-patients
#18
Fatih Sinan Ertaş, Lale Tokgozoglu
OBJECTIVE: The aim of this study was to evaluate the longterm, post-discharge follow-up of antithrombotic management patterns (AMPs), clinical outcomes, and real-life health status of patients hospitalized acute coronary syndrome (ACS). METHODS: A total of 1034 patients hospitalized for ACS within 24 hours of symptom onset who survived to discharge were included. Of those, 514 had ST-segment elevation myocardial infarction (STEMI) and 520 had unstable angina (UA)/non-STEMI (NSTEMI)...
April 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29657046/impact-of-cardiac-hybrid-imaging-guided-patient-management-on-clinical-long-term-outcome
#19
Dominik C Benz, Lara Gaemperli, Christoph Gräni, Elia von Felten, Andreas A Giannopoulos, Michael Messerli, Ronny R Buechel, Oliver Gaemperli, Aju P Pazhenkottil, Philipp A Kaufmann
BACKGROUND: Although randomized trials have provided evidence for invasive fractional flow reserve to guide revascularization, evidence for non-invasive imaging is less well established. The present study investigated whether hybrid coronary computed tomography (CCTA)/single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) can identify patients who benefit from early revascularization compared to medical therapy. METHODS: This retrospective study consists of 414 patients referred for evaluation of known or suspected coronary artery disease (CAD) with CCTA/SPECT hybrid imaging...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29652078/total-cardiovascular-events-analysis-of-the-examine-trial-in-patients-with-type-2-diabetes-and-recent-acute-coronary-syndrome
#20
Matthew A Cavender, William B White, Yuyin Liu, Joseph M Massaro, Richard M Bergenstal, Cyrus R Mehta, Faiez Zannad, Simon Heller, William C Cushman, Christopher P Cannon
BACKGROUND: Alogliptin, a dipeptidyl-peptidase 4 inhibitor, is approved for the treatment of patients with type 2 diabetes. EXAMINE was a randomized-controlled clinical trial designed to demonstrate the cardiovascular safety of alogliptin. In the trial, 5380 patients with established T2DM who had a recent ACS event (between 15-90 days) were randomized to treatment with either alogliptin or placebo. HYPOTHESIS: To better understand and describe the cardiovascular (CV) safety of alogliptin, we analyzed data from the EXAMINE randomized clinical trial to determine whether treatment with alogliptin affected recurrent and total CV events...
April 13, 2018: Clinical Cardiology
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