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JOURNAL ARTICLE
Dhanya Ramachandran, Jonathan P Tyrer, Stefan Kommoss, Anna DeFazio, Marjorie J Riggan, Penelope M Webb, Peter A Fasching, Diether Lambrechts, María J García, Cristina Rodríguez-Antona, Marc T Goodman, Francesmary Modugno, Kirsten B Moysich, Beth Y Karlan, Jenny Lester, Susanne K Kjaer, Allan Jensen, Estrid Høgdall, Ellen L Goode, William A Cliby, Amanika Kumar, Chen Wang, Julie M Cunningham, Stacey J Winham, Alvaro N Monteiro, Joellen M Schildkraut, Daniel W Cramer, Kathryn L Terry, Linda Titus, Line Bjorge, Liv Cecilie Vestrheim Thomsen, Tanja Pejovic, Claus K Høgdall, Iain A McNeish, Taymaa May, David G Huntsman, Jacobus Pfisterer, Ulrich Canzler, Tjoung-Won Park-Simon, Willibald Schröder, Antje Belau, Lars Hanker, Philipp Harter, Jalid Sehouli, Rainer Kimmig, Nikolaus de Gregorio, Barbara Schmalfeldt, Klaus Baumann, Felix Hilpert, Alexander Burges, Boris Winterhoff, Peter Schürmann, Lisa-Marie Speith, Peter Hillemanns, Andrew Berchuck, Sharon E Johnatty, Susan J Ramus, Georgia Chenevix-Trench, Paul D P Pharoah, Thilo Dörk, Florian Heitz
Survival from ovarian cancer depends on the resection status after primary surgery. We performed genome-wide association analyses for resection status of 7705 ovarian cancer patients, including 4954 with high-grade serous carcinoma (HGSOC), to identify variants associated with residual disease. The most significant association with resection status was observed for rs72845444, upstream of MGMT, in HGSOC (p = 3.9 × 10-8 ). In gene-based analyses, PPP2R5C was the most strongly associated gene in HGSOC after stage adjustment...
March 5, 2024: NPJ Genomic Medicine
#2
JOURNAL ARTICLE
Rieke Lober, Maryam Zafarnia, Tomáš Kupec, Julia Wittenborn, Elmar Stickeler, Laila Najjari
Heterotopic pregnancies are a rare phenomenon defined by the simultaneous occurrence of intrauterine and extrauterine pregnancy. The incidence of heterotopic pregnancy occurring through natural fertilization is low but is increased by risk factors such as assisted reproductive techniques or pelvic inflammatory disease increase. We report the case of a 36-year-old female patient in the 6th week of pregnancy who presented to the emergency unit with severe acute lower abdominal pain. Laboratory chemistry and sonography revealed a suspected heterotopic pregnancy...
February 22, 2024: Zeitschrift Für Geburtshilfe und Neonatologie
#3
JOURNAL ARTICLE
Nada Reda, Khaled O Mohamed, Kareem Abdou, Amira A Helwa, Ahmed Elshewy
A new series of 6-(4-fluorophenyl)-2-(methylthio) pyrimidine-5-carbonitrile derivatives were designed and synthesized as EGFR/PI3K dual inhibitors, and potential antiproliferative agents. The new 22 compounds were screened by DTP-NCI against all NCI60 cell lines. Almost all compounds showed cytotoxic activity. Compound 7c showed a promising antitumour activity on CNS cancer (SNB-75), and ovarian cancer (OVAR-4) with IC50 < 0.01, and 0.64 µM, respectively. Fortunately, 7c exhibited a better safety profile on normal cells (WI-38) than doxorubicin by 2...
February 9, 2024: Bioorganic Chemistry
#4
JOURNAL ARTICLE
Bashir Salim, Ryo Nakao, Elisha Chatanga, Olivia Marcuzzi, Muna Ahmed Eissawi, Faisal Almathen, Olivier Hanotte, Guillermo Giovambattista
INTRODUCTION: The Ovar-DRB1 gene, a crucial element of the Major Histocompatibility Complex (MHC) Class II region, initiates adaptive immunity by presenting antigens to T-cells. Genetic diversity in sheep, particularly in MHC Class II genes like Ovar-DRB1, directly influences the specturm of presented antigens impacting immune responses and disease susceptability. Understanding the allelic diversity of Ovar-DRB1 gene in Sudan Desert Sheep (SDS) is essential for uncovering the genetic basis of immune responses and disease resistance, given the the breeds significance in Sudan's unique environment...
February 8, 2024: BMC Genomics
#5
JOURNAL ARTICLE
Rajeswari Pratap, Sreedevi Chennuru, Sudhakar Krovvidi, Jyothisree Chitithoti, Ravi Kumar Pentala
AIM: To explore associations between phenotypic traits and polymorphisms in the DRB1 and GALNT6 gene in Nellore, Deccani and Kenguri sheep naturally infected with Haemonchus contortus. MATERIALS AND METHODS: Blood and faecal samples were collected to evaluate fecal worm egg counts (FEC), packed cell volume (PCV), hemoglobin (Hb), eosinophilia and for DNA isolation. RESULTS: Animals were grouped into susceptible and resistant groups based on EPG counts...
January 19, 2024: Acta Parasitologica
#6
JOURNAL ARTICLE
Jiri Pagac, Vladimir Cerny, Jaroslav Lindner, Bui Quang Hiep
No abstract text is available yet for this article.
January 17, 2024: Kardiologia Polska
#7
JOURNAL ARTICLE
Sabine Heublein, Jacobus Pfisterer, Andreas du Bois, Michael Anglesio M, Behnaz Aminossadati, Irfan Bhatti, Jalid Sehouli, Pauline Wimberger, Fabienne Schochter, Felix Hilpert, Peter Hillemanns, Matthias Kalder, Willibald Schroeder, Sven Mahner, Alexander Burges, Ulrich Canzler, Martina Gropp-Meier, Christian Jackisch, Philipp Harter P, Stefan Kommoss, Frederik Marmé
With more novel drugs being approved for the treatment of ovarian carcinoma (OC), the question remains to what extent patients benefit from anti-angiogenic treatment with bevacizumab, either in combination with poly (ADP-ribose) polymerase (PAPR) inhibitors or as single-agent maintenance. As fibroblast growth factor receptors and their ligands (FGFRs/FGFs) are key players in angiogenic signaling and have been linked to resistance to several drugs, we investigated the prognostic or predictive potential of FGFs/FGFRs signaling in the context of bevacizumab treatment within the prospective phase III AGO-OVAR 11/ICON-7 study...
December 26, 2023: Laboratory Investigation; a Journal of Technical Methods and Pathology
#8
JOURNAL ARTICLE
Randall Arguedas, Esteban Castro, Lizbeth Ovares
BACKGROUND: The Central American bushmaster ( Lachesis stenophrys) is one of the largest pitvipers in the Americas, with relatively low abundance, suspected population declines, and continuing loss, fragmentation, and habitat degradation. AIM: Conservation actions, both in the wild and in captivity, bear the need for health parameters that allow managers and veterinarians to have a better understanding of health, especially when there are relatively few individuals in captivity to obtain robust information since there is no published information on the genus...
November 2023: Open Veterinary Journal
#9
REVIEW
Ina Sorge, Franz Wolfgang Hirsch
BACKGROUND: Abnormalities of the ovary are frequently seen on ultrasound examination, sometimes symptomatic, but are more commonly asymptomatic. PURPOSE: Presentation of the most important entities of ovarian masses and their imaging features in infants and children. Discussion of criteria for differentiation between benign and potentially malignant masses. MATERIALS AND METHODS: Review of current literature and presentation of image examples...
November 10, 2023: Radiologie (Heidelb)
#10
RANDOMIZED CONTROLLED TRIAL
Florian Heitz, Christian Marth, Stéphanie Henry, Alexander Reuss, David Cibula, Lydia Gaba Garcia, Nicoletta Colombo, Barbara Schmalfeld, Nikolaus de Gregorio, Pauline Wimberger, Annette Hasenburg, Jalid Sehouli, Martina Gropp-Meier, Philip C Schouten, Eric Hahnen, Jan Hauke, Sandra Polleis, Philipp Harter
BACKGROUND: Phase III trial data have shown a significant benefit by the addition of a maintenance treatment with niraparib, irrespective of BRCA or HRD status, in patients with advanced high-grade ovarian cancers; and, a significant benefit of the combination of olaparib and bevacizumab compared with bevacizumab monotherapy in HRD positive patients. However, it is unclear whether a PARP inhibitor monotherapy is sufficient, or if the addition of bevacizumab is needed. PRIMARY OBJECTIVES: This trial will investigate if the treatment strategy of carboplatin/paclitaxel/bevacizumab/niraparib is superior to the treatment of carboplatin/paclitaxel/niraparib in an all-comer population...
December 4, 2023: International Journal of Gynecological Cancer
#11
JOURNAL ARTICLE
Alvaro Aguilar-Setién, Mónica Salas-Rojas, Guillermo Gálvez-Romero, Cenia Almazán-Marín, Andrés Moreira-Soto, Jorge Alfonso-Toledo, Cirani Obregón-Morales, Martha García-Flores, Anahí García-Baltazar, Jordi Serra-Cobo, Marc López-Roig, Nora Reyes-Puma, Marta Piche-Ovares, Mario Romero-Vega, Daniel Felipe Barrantes Murillo, Claudio Soto-Garita, Alejandro Alfaro-Alarcón, Eugenia Corrales-Aguilar, Osvaldo López-Díaz, Dominique Pontier, Ondine Filippi-Codaccioni, Jean-Baptiste Pons, Jeanne Duhayer, Jan Felix Drexler
Bats are important natural reservoir hosts of a diverse range of viruses that can be transmitted to humans and have been suggested to play an important role in the Zika virus (ZIKV) transmission cycle. However, the exact role of these animals as reservoirs for flaviviruses is still controversial. To further expand our understanding of the role of bats in the ZIKV transmission cycle in Latin America, we carried out an experimental infection in wild-caught Artibeus lituratus bats and sampled several free-living neotropical bats across three countries of the region...
July 24, 2023: PLoS Neglected Tropical Diseases
#12
Shafaqat M Rahman, Catherine Hauser, Stefanie Faucher, Elana Fine, Anne E Luebke
UNLABELLED: Motion-induced anxiety and agoraphobia are more frequent symptoms in patients with vestibular migraine than migraine without vertigo. The neuropeptide calcitonin gene-related peptide (CGRP) is a therapeutic target for migraine and vestibular migraine, but the link between motion hypersensitivity, anxiety, and CGRP is relatively unexplored, especially in preclinical mouse models. To further examine this link, we tested the effects of systemic CGRP and off-vertical axis rotation (OVAR) on elevated plus maze (EPM) and rotarod performance in male and female C57BL/6J mice...
August 2, 2023: bioRxiv
#13
JOURNAL ARTICLE
Jing-Ying Liao, Hui Tang, Wei-Jie Xiong, Tian-Ning Liu, Jie-Yu Li, Jun-Yong Xia, Chao-Ting Xiao
Tembusu virus (TMUV) is a member of the genus Flavivirus in the family Flaviviridae. Currently, TMUV was classified into 4 distinct clusters, with cluster 2 strains widely distributed in duck and goose populations in Asia, causing significant economic losses to the producing industries. In this study, a novel TMUV strain TMUV/goose/CHN/2019/HNU-NX2 (HNU-NX2-2019) was isolated and characterized from geese with ovaritis from Hunan province, China. Phylogenetic analyses of genome and the E gene indicated the present TMUV could be grouped into the newly defined TMUV cluster 3...
June 14, 2023: Poultry Science
#14
JOURNAL ARTICLE
Zhen Wang, Junbo Hu
RATIONALE: Anastomosing hemangioma (AH) is a rare benign neoplastic vascular lesion that histologically resembles a well-differentiated angiosarcoma. AH commonly involves the urinary system and testes. However, these tumors can also involve the ovaries in some rare cases. This manuscript presents the case of a 28-year-old Chinese woman diagnosed with ovarian AH. PATIENT CONCERNS: The woman was admitted to the hospital with a 4-month history of a right ovarian mass discovered by ultrasound (US) after a spontaneous abortion...
May 12, 2023: Medicine (Baltimore)
#15
JOURNAL ARTICLE
Franziska Mergel, Fabienne Schochter, Nikolaus DeGregorio, Wolfgang Janni, Frank Reister, Ulrike Friebe-Hofmann, Beate Hüner
Adnexal masses affect 2-10% of all pregnancies. The highest incidence of 1-6% can be seen in the first trimester, with a high rate of spontaneous remission. Two percent of these masses are malignant neoplasms or borderline tumors. A rare benign mass of the adnexa in pregnancy is hyperreactio luteinalis characterised by bilateral, multicystic ovaries with a frequent occurrence in the 3rd trimester. Clinical signs include maternal hyperandrogenaemia with virilisation, hyperemesis, nonspecific abdominal pain or laboratory findings of hyperthyroidism and elevated ß-HCG...
May 2, 2023: Zeitschrift Für Geburtshilfe und Neonatologie
#16
JOURNAL ARTICLE
Pauline Wimberger, Jacobus Pfisterer, Andreas du Bois, Felix Hilpert, Markus Kerkman, Jalid Sehouli, Sven Mahner, Nikolaus de Gregorio, Lars Hanker, Florian Heitz, Frederik Marmé, Linn Woelber, Laura Holtmann, Gabriele Elser, Philipp Harter
OBJECTIVE: The quality assurance program for ovarian cancer (QS-OVAR) evaluates the implementation of treatment standards and impact on survival for International Federation of Gynecology and Obstetrics (FIGO) stage I ovarian cancer. METHODS: Patients with a first diagnosis of ovarian cancer, diagnosed in the third quarter of 2004, 2008, 2012, and 2016, were documented. Surgical quality was categorized as optimal (maximum one surgical item missing) versus suboptimal (≥2 surgical items missing)...
March 31, 2023: International Journal of Gynecological Cancer
#17
REVIEW
Philipp Harter, Gerhard Bogner, Luis Chiva, David Cibula, Nicole Concin, Christina Fotopoulou, Antonio Gonzalez-Martin, Frederic Guyon, Viola Heinzelmann-Schwarz, Frederic Kridelka, Sven Mahner, Frederik Marmé, Christian Marth, Philippe Morice, Zoltán Novák, Andrea Papadia, Isabelle Ray-Coquard, Mikuláš Redecha, Andres Redondo, Richard Schwameis, Jalid Sehouli, Manuela Undurraga, Toon Van Gorp, Ignace Vergote
An international joint statement about the use of hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer was published in 2016, warning about the uncritical use of HIPEC outside controlled studies. This statement has now been updated after the most recent literature was reviewed by the participating study groups and societies. HIPEC became a treatment option in patients with advanced colon cancer after positive results of a randomized trial comparing surgery and HIPEC versus palliative treatment alone...
March 24, 2023: Bulletin du Cancer
#18
JOURNAL ARTICLE
Bertrand Mercier, Nitish B Chandrasekaran, Piero Colonna
Estimating the speed of sound for the dense vapor phase of D6 (dodecamethylcyclohexasiloxane, C12 H36 O6 Si6 ) is particularly relevant to the study of nonideal compressible fluid dynamics (NICFD), the gas dynamics of fluids whose properties depart significantly from those related by the ideal gas model. If molecular complexity is sufficiently large, dense vapor flows may exhibit so-called nonclassical gasdynamic effects, and D6 is a candidate for experimental studies aimed at proving for the first time the existence of these exotic phenomena...
March 9, 2023: Journal of Chemical and Engineering Data
#19
JOURNAL ARTICLE
O Kuldavletova, P Denise, H Normand, G Quarck, O Etard
While the influence of the vestibular and extra-vestibular gravity signals on the cardiovascular system has been demonstrated, there is little evidence that visual stimuli can trigger cardiovascular responses. Furthermore, there is no evidence of interaction between visual and vestibular signals in autonomic control, as would be expected since they are highly integrated. The present study explored the cardiovascular responses to vestibular and visual stimuli in normal subjects. We hypothesized that the visual stimuli would modify the cardiovascular response to vestibular stimulation, especially when the latter is ambiguous with respect to gravity...
March 14, 2023: Scientific Reports
#20
JOURNAL ARTICLE
Sheng Yang, Yonghong Shi, Jingxian Wu, Qiusheng Chen
Duck Tembusu virus (DTMUV) is an emerging avian flavivirus characterized by causing severe ovaritis and neurological symptoms in ducks. The pathology of the central nervous system (CNS) caused by DTMUV is rarely studied. This study aimed to systematically investigate the ultrastructural pathology of the CNS of ducklings and adult ducks infected with DTMUV via transmission electron microscopy technology at a cytopathological level. The results showed that DTMUV caused extensive lesions in the brain parenchyma of ducklings and slight damage in adult ducks...
2023: Frontiers in Microbiology
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