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Ozen and takayasu

Seza Ozen, Nazire Pinar Acar-Ozen
PURPOSE OF REVIEW: The review aims to summarize the recent findings in vasculitis that may have an impact in our understanding or management of these diseases. RECENT FINDINGS: We are learning more about monogenic diseases that closely mimic the pediatric vasculitides. Deficiency of adenosine deaminase 2 can present with a polyarteritis nodosa (PAN)-like picture and should be included in the differential of all pediatric cases of PAN with a family history or in cases with early stroke, or in cases resistant to conventional therapy...
September 2017: Current Opinion in Rheumatology
Ezgi Deniz Batu, Hafize Emine Sönmez, Tuncay Hazırolan, Fatih Özaltın, Yelda Bilginer, Seza Özen
OBJECTIVE: Our aim was to describe our experience with tocilizumab (interleukin 6 receptor antagonist) treatment in children with Takayasu arteritis and to review previous studies regarding tocilizumab use in Takayasu arteritis patients. PATIENTS AND METHODS: We reviewed the charts of all pediatric Takayasu arteritis patients followed up between 2000 and 2015 in Department of Pediatric Rheumatology in Hacettepe University, Ankara, Turkey, and we present the patients who were treated with tocilizumab...
February 2017: Seminars in Arthritis and Rheumatism
Ebru Aypar, Ash Celebi-Tayfur, Melike Keser, Dursun Odabaş, Fatih Ozaltin, Yahya Paksoy, Seza Ozen
Takayasu arteritis (TA) is a large vessel vasculitis that involves the aorta, its major branches and pulmonary arteries. Diagnosis of TA during childhood remains challenging due to the non-specific symptoms. We report a four-year-old girl presenting with fever, fatigue, weight loss, and elbow pain who was later diagnosed as childhood TA. On admission, she had fever, hypertension, decreased pulses, bruits, hepatosplenomegaly, and increased erythrocyte sedimentation rate and C-reactive protein level. Computed tomography angiography showed luminal narrowing and wall thickening in ascending aorta, brachiocephalic, left common carotid and left vertebral arteries and descending aorta...
September 2012: Turkish Journal of Pediatrics
Erkan Demirkaya, Seza Ozen, Angela Pistorio, Roberta Galasso, Angelo Ravelli, Rachana Hasija, Esra Baskin, Frank Dressler, Michel Fischbach, Julia Garcìa Consuegra, Nicolae Iagaru, Srdjan Pasic, Salvatore Scarpato, Marion A J van Rossum, Maria Teresa Apaz, Judith Barash, Giuseppina Calcagno, Benito Gonzalez, Esther Hoppenreijs, Maka Ioseliani, Henryka Mazur-Zielinska, Olga Vougiouka, Nico Wulffraat, Raashid Luqmani, Alberto Martini, Nicolino Ruperto, Pavla Dolezalova
OBJECTIVES: To evaluate the performance of the Birmingham Vasculitis Activity Score (BVAS) v3 and the Disease Extent Index (DEI) for the assessment of disease activity in 4 primary childhood (c-) systemic vasculitides. METHODS: Patients fulfilling the EULAR/PRINTO/PRES (Ankara) c-vasculitis classification criteria for Henoch-Schönlein purpura (HSP), childhood (c) polyarteritis nodosa (c-PAN), c-Wegener's granulomatosis (c-WG) and c-Takayasu arteritis (c-TA) with disease duration at the time of diagnosis ≤3 months were extracted from the PRINTO database...
January 2012: Clinical and Experimental Rheumatology
Seza Ozen, Angela Pistorio, Silvia M Iusan, Aysin Bakkaloglu, Troels Herlin, Riva Brik, Antonella Buoncompagni, Calin Lazar, Ilmay Bilge, Yosef Uziel, Donato Rigante, Luca Cantarini, Maria Odete Hilario, Clovis A Silva, Mauricio Alegria, Ximena Norambuena, Alexandre Belot, Yackov Berkun, Amparo Ibanez Estrella, Alma Nunzia Olivieri, Maria Giannina Alpigiani, Ingrida Rumba, Flavio Sztajnbok, Lana Tambic-Bukovac, Luciana Breda, Sulaiman Al-Mayouf, Dimitrina Mihaylova, Vyacheslav Chasnyk, Claudia Sengler, Maria Klein-Gitelman, Djamal Djeddi, Laura Nuno, Chris Pruunsild, Jurgen Brunner, Anuela Kondi, Karaman Pagava, Silvia Pederzoli, Alberto Martini, Nicolino Ruperto
OBJECTIVES: To validate the previously proposed classification criteria for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA). METHODS: Step 1: retrospective/prospective web-data collection for children with HSP, c-PAN, c-WG and c-TA with age at diagnosis <or=18 years. Step 2: blinded classification by consensus panel of a representative sample of 280 cases. Step 3: statistical (sensitivity, specificity, area under the curve and kappa-agreement) and nominal group technique consensus evaluations...
May 2010: Annals of the Rheumatic Diseases
Nicolino Ruperto, Seza Ozen, Angela Pistorio, Pavla Dolezalova, Paul Brogan, David A Cabral, Ruben Cuttica, Raju Khubchandani, Daniel J Lovell, Kathleen M O'Neil, Pierre Quartier, Angelo Ravelli, Silvia M Iusan, Giovanni Filocamo, Claudia Saad Magalhães, Erbil Unsal, Sheila Oliveira, Claudia Bracaglia, Arvind Bagga, Valda Stanevicha, Silvia Magni Manzoni, Polyxeni Pratsidou, Loredana Lepore, Graciela Espada, Isabella Kone-Paut, Isabelle Kone Paut, Francesco Zulian, Patrizia Barone, Zelal Bircan, Maria del Rocio Maldonado, Ricardo Russo, Iris Vilca, Kjell Tullus, Rolando Cimaz, Gerd Horneff, Jordi Anton, Stella Garay, Susan Nielsen, Giancarlo Barbano, Alberto Martini
OBJECTIVES: To report methodology and overall clinical, laboratory and radiographic characteristics for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA) classification criteria. METHODS: The preliminary Vienna 2005 consensus conference, which proposed preliminary criteria for paediatric vasculitides, was followed by a EULAR/PRINTO/PRES - supported validation project divided into three main steps...
May 2010: Annals of the Rheumatic Diseases
Necati Balamtekin, Figen Gürakan, Seza Ozen, Bena Oguz, Beril Talim
UNLABELLED: Takayasu's arteritis (TA) and ulcerative colitis (UC) are chronic inflammatory diseases of unknown aetiology, and their coexistence is very rare. A 14-year-old Turkish girl presented with abdominal pain, nausea, vomiting and weight loss. UC was diagnosed based on physical examination and laboratory investigations and was confirmed by colonoscopic biopsies. TA developed approximately 1 year later, and was diagnosed with angiography performed for ongoing severe abdominal pain in spite of well-controlled UC...
August 2009: Acta Paediatrica
Nilgun Cakar, Fatos Yalcinkaya, Ali Duzova, Salim Caliskan, Aydan Sirin, Ayse Oner, Esra Baskin, Kenan Bek, Alper Soylu, Suat Fitoz, Aysun Karabay Bayazit, Zelal Bircan, Seza Ozen, Nermin Uncu, Mesiha Ekim
OBJECTIVE: To retrospectively evaluate the clinical features, angiographic findings, and outcomes of children with Takayasu arteritis (TA) in Turkey. METHODS: Clinical, laboratory, and angiographic findings and outcomes of 19 children with TA were evaluated with a retrospective chart review. The criteria for inclusion were those proposed by the American College of Rheumatology. RESULTS: Mean followup period was 35.89 +/- 40.75 months (range 1-168, median 30)...
May 2008: Journal of Rheumatology
Seza Ozen, Ali Duzova, Aysin Bakkaloglu, Yelda Bilginer, Barbaros E Cil, Metin Demircin, Jean Claude Davin, Mehmet Bakkaloğlu
OBJECTIVE: To review the results of our treatment protocol in the last 7 years. STUDY DESIGN: Six patients (4 girls, 2 boys) with an age range of 12 to 17 years were diagnosed with Takayasu arteritis (TA) during this period. Patients were allocated to receive (1) oral steroids and methotrexate (MTX) (12.5 mg/m(2)/week) if they had disease limited to one side of the diaphragm only without pulmonary disease involvement (two patients); and (2) oral steroids and oral cyclophosphamide (CYC) (maximum total dose 150 mg/kg) followed by oral MTX for maintenance as above if the disease was more widespread (four patients)...
January 2007: Journal of Pediatrics
Michael J Dillon, Seza Ozen
There has been, for many years, a need for an acceptable classification of childhood vasculitis as well as criteria for classifying specific sub-categories of vasculitic disease affecting the young. Hitherto, there has been, with certain exceptions, much reliance on adult classification systems and criteria that have not proved entirely satisfactory. A recent International Consensus Conference held in Vienna in June 2005 attempted to rectify this state of affairs. It resulted in a new proposal for childhood vasculitis classification and proposals of classification criteria for several important categories of childhood vasculitis including Henoch-Schonlein purpura, Kawasaki disease, polyarteritis nodosa (with additionally definitions for cutaneous and microscopic polyarteritis), Wegener granulomatosis and Takayasu arteritis...
September 2006: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Seza Ozen, Aysin Bakkaloglu, Ruhan Dusunsel, Oguz Soylemezoglu, Fatih Ozaltin, Hakan Poyrazoglu, Ozgur Kasapcopur, Ozan Ozkaya, Fatos Yalcinkaya, Ayse Balat, Nurdan Kural, Osman Donmez, Harika Alpay, Ali Anarat, Sevgi Mir, Ayfer Gur-Guven, Ferah Sonmez, Faysal Gok
AIM: The aims of this study were to evaluate the characteristics of childhood vasculitides and to establish the first registry in Turkey, an eastern Mediterranean country with a white population. PATIENTS AND METHODS: A questionnaire was distributed to the main referral centers asking for the registration of the Henoch-Schönlein purpura (HSP) patients in the last calendar year only and 5 years for other vasculitides. Demographic, clinical, and laboratory data were assessed...
February 2007: Clinical Rheumatology
S Ozen, N Ruperto, M J Dillon, A Bagga, K Barron, J C Davin, T Kawasaki, C Lindsley, R E Petty, A M Prieur, A Ravelli, P Woo
BACKGROUND: There has been a lack of appropriate classification criteria for vasculitis in children. OBJECTIVE: To develop a widely accepted general classification for the vasculitides observed in children and specific and realistic classification criteria for common childhood vasculitides (Henoch-Schönlein purpura (HSP), Kawasaki disease (KD), childhood polyarteritis nodosa (PAN), Wegener's granulomatosis (WG), and Takayasu arteritis (TA)). METHODS: The project was divided into two phases: (1) the Delphi technique was used to gather opinions from a wide spectrum of paediatric rheumatologists and nephrologists; (2) a consensus conference using nominal group technique was held...
July 2006: Annals of the Rheumatic Diseases
S Ozen
The common vasculitides of childhood are more self-limited than those in adults. Clinical evidence suggests that infectious agents may have a significant role in the aetiology of these diseases although exact pathogenic mechanisms are not known. One of the most frequent of such diseases in childhood is Henoch-Schönlein purpura. The controversies regarding the management of gastrointestinal and renal disease and suggested treatments are reviewed. The limitations of current definitions for polyarteritis nodosa are discussed and a new classification tree for this disease is introduced...
July 2002: Best Practice & Research. Clinical Rheumatology
A Duzova, O Türkmen, A Cinar, S Cekirge, U Saatci, S Ozen
The aetiology of Takayasu's arteritis is unknown, but an association with tuberculosis has been reported. We report the case of a 12-year-old-boy with Takayasu's arteritis: his blood pressure was 150/90 mmHg and fundoscopic examination showed grade I hypertensive changes. A tuberculin test was positive and acid-fast bacteria were seen in the urine. Angiography revealed involvement of the descending aorta, thoracic aorta and upper abdominal aorta, with fusiform enlargement and no filling of the left renal artery...
2000: Clinical Rheumatology
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