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https://www.readbyqxmd.com/read/29135941/the-small-heat-shock-protein-%C3%AE-crystallin-b-shows-neuroprotective-properties-in-a-glaucoma-animal-model
#1
Fabian Anders, Aiwei Liu, Carolina Mann, Julia Teister, Jasmin Lauzi, Solon Thanos, Franz H Grus, Norbert Pfeiffer, Verena Prokosch
Glaucoma is a neurodegenerative disease that leads to irreversible retinal ganglion cell (RGC) loss and is one of the main causes of blindness worldwide. The pathogenesis of glaucoma remains unclear, and novel approaches for neuroprotective treatments are urgently needed. Previous studies have revealed significant down-regulation of α-crystallin B as an initial reaction to elevated intraocular pressure (IOP), followed by a clear but delayed up-regulation, suggesting that this small heat-shock protein plays a pathophysiological role in the disease...
November 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29114841/effect-of-cromakalim-prodrug-1-cklp1-on-aqueous-humor-dynamics-and-feasibility-of-combination-therapy-with-existing-ocular-hypotensive-agents
#2
Uttio Roy Chowdhury, Tommy A Rinkoski, Cindy K Bahler, J Cameron Millar, Jacques A Bertrand, Bradley H Holman, Joseph M Sherwood, Darryl R Overby, Kristen L Stoltz, Peter I Dosa, Michael P Fautsch
Purpose: Cromakalim prodrug 1 (CKLP1) is a water-soluble ATP-sensitive potassium channel opener that has shown ocular hypotensive properties in ex vivo and in vivo experimental models. To determine its mechanism of action, we assessed the effect of CKLP1 on aqueous humor dynamics and in combination therapy with existing ocular hypotensive agents. Methods: Outflow facility was assessed in C57BL/6 mice by ex vivo eye perfusions and by in vivo constant flow infusion following CKLP1 treatment...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29102674/protective-effects-of-biodegradable-collagen-implants-on-thinned-sclera-after-strabismus-surgery-a-paired-eye-study
#3
Tae Keun Yoo, Sueng-Han Han, Jinu Han
PURPOSE: To determine the efficacy of a biodegradable Ologen (Aeon Astron Europe BV, Leiden, The Netherlands) collagen matrix in reducing the blue color change due to exposed thinned sclera after strabismus surgery. METHODS: Fourteen patients with intermittent exotropia undergoing symmetric bilateral lateral rectus recession surgery were included in this prospective, randomized, paired-eye controlled study. In each patient, Ologen was implanted at the original rectus insertion site in one randomly selected eye; the other eye underwent conventional surgery...
November 1, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29074388/functional-assessment-of-the-aqueous-humour-distal-outflow-pathways-in-bovine-eyes-using-time-of-flight-magnetic-resonance-tomography
#4
Thomas Wecker, Christian van Oterendorp, Wilfried Reichardt
The major part of the aqueous humor leaves the eye through the "conventional outflow pathway", consisting of the trabecular meshwork, Schlemm's canal, collector channels, an intrasceral plexus and the episcleral veins. While the trabecular meshwork is well characterized, little is known about anatomical and functional features of the peripheral outflow tract beyond Schlemm's canal. The emergence of minimally-invasive glaucoma surgery directly targeting the outflow resistance in the trabecular meshwork has elicited growing interest in these structures...
October 23, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29071267/uveal-melanoma-cell-seeding-after-transretinal-tumor-biopsy
#5
Konrad R Koch, Ahmed M Hishmi, Monika Ortmann, Ludwig M Heindl
BACKGROUND/AIMS: To report a case and the histopathology of uveal melanoma cell seeding following transretinal tumor biopsy for a suspected uveal lesion. METHODS: Interventional case report. RESULTS: A 66-year-old male presented with a pigmented perilimbal episcleral lesion overlying an intraocular mass at the pars plana, 3.5 years after transretinal biopsy and ruthenium plaque brachytherapy for a choroidal melanoma at the posterior pole. The patient underwent enucleation of the eye...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29066280/implantation-and-testing-of-a-novel-episcleral-pressure-transducer-a-new-approach-to-telemetric-intraocular-pressure-monitoring
#6
Siegfried Mariacher, Martina Ebner, José Hurst, Peter Szurman, Kai Januschowski
Measurement of intraocular pressure (IOP) is an essential tool in monitoring glaucoma. Single IOP assessments during clinical routine examinations represent punctual values and are not able to identify IOP fluctuations and spikes. Telemetric IOP measurements are able to monitor IOP during the day and night, and are location-independent. Six telemetric episcleral IOP sensors were investigated after minimally invasive subconjunctival implantation in 6 eyes of 6 New-Zealand-White rabbits. Three of the 4 edges of the implant were fixated intrasclerally with non-absorbable sutures...
October 21, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29065394/long-non-coding-rna-malat1-mediates-retinal-ganglion-cell-apoptosis-through-the-pi3k-akt-signaling-pathway-in-rats-with-glaucoma
#7
Hai-Bo Li, Qi-Sheng You, Li-Xin Xu, Li-Xin Sun, Aman Shah Abdul Majid, Xiao-Bo Xia, Dan Ji
BACKGROUND/AIMS: The aim of the present study is to investigate the effect of long non-coding RNA-MALAT1 (LncRNA-MALAT1) on retinal ganglion cell (RGC) apoptosis mediated by the PI3K/Akt signaling pathway in rats with glaucoma. METHODS: RGCs were isolated and cultured, and monoclonal antibodies (anti-rat Thy-1, Brn3a and RBPMS) were examined by immunocytochemistry. An overexpression vector MALAT1-RNA activation (RNAa), gene knockout vector MALAT1-RNA interference (RNAi), and control vector MALAT1-negative control (NC) were constructed...
October 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29023165/clinical-characteristics-of-ocular-sarcoidosis-a-population-based-study-1976-2013
#8
Patompong Ungprasert, Andrea A Tooley, Cynthia S Crowson, Eric L Matteson, Wendy M Smith
PURPOSE: To characterize the epidemiology and clinical characteristics of ocular involvement in patients with systemic sarcoidosis. METHODS: An inception cohort of patients with systemic sarcoidosis in 1976-2013 in Olmsted County, Minnesota, was identified based on comprehensive individual medical record review. Medical records of those patients were then reviewed for ocular involvement. RESULTS: A total of 345 incident cases of systemic sarcoidosis were identified...
October 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29016520/episcleral-venous-outflow-a-potential-outcome-marker-for-istent-surgery
#9
Cristina Bostan, Paul Harasymowycz
PURPOSE: (1) To propose the use of episcleral venous outflow (EVO) as an outcome marker of iStent surgery, and an EVO grading scale. (2) To determine the association of EVO with: (a) postoperative intraocular pressure (IOP) and medication burden; (b) iStent patency status. PATIENTS AND METHODS: Retrospective cohort study including 151 glaucomatous eyes having undergone iStent-phacoemulsification surgery. Demographic and preoperative data (IOP, number of anti-glaucoma medications, glaucoma type and stage, maximal IOP) were collected...
October 9, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28986598/hydrogen-sulfide-protects-retinal-ganglion-cells-against-glaucomatous-injury-in-vitro-and-in-vivo
#10
Hanhan Liu, Fabian Anders, Solon Thanos, Carolina Mann, Aiwei Liu, Franz H Grus, Norbert Pfeiffer, Verena Prokosch-Willing
Purpose: Hydrogen sulfide (H2S) is recognized as a novel third signaling molecule and gaseous neurotransmitter. Recently, cell protective properties within the central nervous and cardiovascular system have been proposed. Our purpose was to analyze the expression and neuroprotective effects of H2S in experimental models of glaucoma. Methods: Elevated IOP was induced in Sprague-Dawley rats by means of episcleral vein cauterization. After 7 weeks, animals were killed and the retina was analyzed with label-free mass spectrometry...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28986593/effect-of-body-position-on-epsicleral-venous-pressure-in-healthy-subjects
#11
COMPARATIVE STUDY
Nitika Arora, Jay W McLaren, David O Hodge, Arthur J Sit
Purpose: The mechanism of IOP change during a body position change is poorly understood. In this study, we investigated changes in episcleral venous pressure (EVP) between two body positions, sitting and inclined, and compared this with changes in IOP. Methods: This study was a prospective, comparative case series of 43 eyes of 24 healthy volunteers. IOP was measured using a pneumatonometer in the seated position. EVP was then measured in a selected episcleral vein by using an automated, slit-lamp-mounted venomanometer...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28970729/patients-with-inflammatory-bowel-disease-have-increased-risk-of-autoimmune-and-inflammatory-diseases
#12
Morten L Halling, Jens Kjeldsen, Torben Knudsen, Jan Nielsen, Lars Koch Hansen
AIM: To investigate whether immune mediated diseases (IMD) are more frequent in patients with inflammatory bowel disease (IBD). METHODS: In this population based registry study, a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16, 2013. Controls were randomly selected from the Danish Civil Registration System (CRS) and matched for sex, age, and municipality. We used ICD 10 codes to identify the diagnoses of the included patients...
September 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28961602/impact-of-video-technology-for-improving-success-of-medial-canthus-episcleral-anesthesia-in-ophthalmology
#13
Gilles Guerrier, Pierre-Raphaël Rothschild, Mathieu Lehmann, Frédéric Azan, Christophe Baillard
BACKGROUND AND OBJECTIVES: Efficient learning of regional anesthesia in ophthalmology remains challenging because trainees are afforded limited opportunity to practice ocular anesthesia. The aim of this prospective, randomized, blinded study was to determine whether teaching with video improves regional anesthesia skills of residents in ophthalmology. METHODS: From January to October 2016, 32 novice anesthesiology residents were evaluated while performing medial canthus episcleral procedures during a 5-day rotation...
November 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28957561/clinical-characteristics-of-inflammatory-ocular-disease-in-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-a-retrospective-cohort-study
#14
Patompong Ungprasert, Cynthia S Crowson, Rodrigo Cartin-Ceba, James A Garrity, Wendy M Smith, Ulrich Specks, Eric L Matteson, Ashima Makol
Objective: To characterize the clinical correlates and outcome of inflammatory ocular disease (IOD) among patients with ANCA-associated vasculitides (AAV). Methods: Medical records of potential cases of AAV seen at Mayo Clinic from 2003 to 2013, inclusive, were reviewed to identify confirmed cases meeting the diagnosis of AAV using the Chapel Hill Consensus Conference 2012 descriptors. Records of confirmed cases of AAV were then further reviewed for IOD, and clinical characteristics, treatment and outcomes abstracted...
October 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28932076/ophthalmic-manifestations-in-patients-with-inflammatory-bowel-disease-a-review
#15
REVIEW
Leandro Lopes Troncoso, Ana Luiza Biancardi, Haroldo Vieira de Moraes, Cyrla Zaltman
Clinical manifestations of inflammatory bowel disease (IBD) are not locally restricted to the gastrointestinal tract, and a significant portion of patients have involvement of other organs and systems. The visual system is one of the most frequently affected, mainly by inflammatory disorders such as episcleritis, uveitis and scleritis. A critical review of available literature concerning ocular involvement in IBD, as it appears in PubMed, was performed. Episcleritis, the most common ocular extraintestinal manifestation (EIM), seems to be more associated with IBD activity when compared with other ocular EIMs...
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28916114/-scleritis-and-episcleritis
#16
REVIEW
E Héron, T Bourcier
Episcleritis is generally a benign disease with a self-limited course, while scleritis is a severe ocular condition due to a risk of impaired vision in one-fifth of patients and its association with systemic diseases in one third of them. Infectious scleritis, representing 8 % of the etiologies, is mainly of herpetic origin (varicella zoster and herpes simplex viruses). A systemic autoimmune disease is observed in roughly 30 % of scleritis patients: inflammatory rheumatisms (15 %), firstly rheumatoid polyarthritis, systemic vasculitides (8 %), mainly granulomatosis with polyangiitis (Wegener's) and polychondritis, and less often inflammatory bowel disease and systemic lupus erythematosus...
October 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28867543/clinical-outcomes-of-hypofractionated-radiation-therapy-for-choroidal-metastases-symptom-palliation-tumor-control-and-survival
#17
Ezra Hahn, Normand Laperriere, Hatem Krema, Juan P Velazquez-Martin, Sohel Somani, John Waldron, Rand Simpson, David Payne, Caroline Chung
PURPOSE: External beam radiation therapy (RT) is an effective palliative treatment for patients with choroidal metastases and is aimed at preserving vision and obtaining local tumor control. Delivery of 30 to 40 Gy in 2-Gy daily fractions is a standard approach at many centers. This study reports the outcomes of a hypofractionated schedule of 20 Gy in 5 fractions in this palliative setting. METHODS AND MATERIALS: We conducted a retrospective review of patients who were treated with RT (20 Gy in 5 fractions) for choroidal metastases between January 1999 and November 2012...
June 29, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28820646/consequences-of-puberty-on-efficacy-of-intraocular-pressure-lowering-drugs-in-male-dutch-belted-rabbits
#18
Cassandra L Hays, Kingsley C Okafor, Shan Fan, Robin High, Dhirendra P Singh, Carol B Toris
PURPOSE: To investigate the changes in intraocular pressure (IOP), aqueous flow, and outflow facility, as well as efficacy of IOP-lowering drugs before and after sexual development in rabbits. METHODS: Male Dutch-belted rabbits were studied at night between the ages of 8 and 44 weeks. During these times, body weight, testicular volume, and serum testosterone were measured to monitor sexual maturity. Ocular measurements included anterior chamber depth, central corneal thickness, IOP, aqueous flow, and outflow facility...
August 18, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28818442/mri-based-treatment-planning-and-dose-delivery-verification-for-intraocular-melanoma-brachytherapy
#19
Jacqueline Esthappan Zoberi, Jose Garcia-Ramirez, Samantha Hedrick, Vivian Rodriguez, Carol G Bertelsman, Stacie Mackey, Yanle Hu, H Michael Gach, P Kumar Rao, Perry W Grigsby
PURPOSE: Episcleral plaque brachytherapy (EPB) planning is conventionally based on approximations of the implant geometry with no volumetric imaging following plaque implantation. We have developed an MRI-based technique for EPB treatment planning and dose delivery verification based on the actual patient-specific geometry. METHODS AND MATERIALS: MR images of 6 patients, prescribed 85 Gy over 96 hours from Collaborative Ocular Melanoma Study-based EPB, were acquired before and after implantation...
August 14, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28810183/computer-modeling-of-drug-delivery-in-the-anterior-human-eye-after-subconjunctival-and-episcleral-implantation
#20
Feng Zhang, Han Chen, Yukan Huang
Recently, subconjunctival and episcleral implants have been proposed in the treatment of anterior eye diseases. In order to improve the delivery efficacy, it is important to understand the transport process of the implanted drugs. A 3D computational model, which includes heat transfer, aqueous humor (AH) flow, as well as diffusive and convective transport of the drug concentration, is developed to study the temporal and spatial evolution of the drug in the anterior segment of a human eye after subconjunctival and episcleral implantation, with a focus on drug delivery to three targets: iris, lens, and trabecular meshwork (TM)...
July 31, 2017: Computers in Biology and Medicine
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