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https://www.readbyqxmd.com/read/28078992/smoking-and-eye-pathologies-a-systemic-review-part-ii-retina-diseases-uveitis-optic-neuropathies-thyroid-associated-orbitopathy
#1
Małgorzata Nita, Andrzej Grzybowski
BACKGROUND: Tobacco smoking has detrimental influence on human health. AIM: The analysis of influence of tobacco smoking on retina diseases, uveitis, optic neuropathies, and thyroid-associated orbitopathy in adults and children. METHODS: A comprehensive review of the literature performed through MEDLINE and PubMed searches, covering the years 2000-2016. RESULTS: In adults, tobacco smoking is a strong risk factor for age-related macular degeneration, polypoidal choroidal vasculopathy, uveitis and inflamed cystoid macular edema as well as Grave`s ophthalmopathy...
January 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28064423/pathophysiology-diagnosis-and-management-of-glaucoma-associated-with-sturge-weber-syndrome
#2
REVIEW
Usman Javaid, Muhammad Hassaan Ali, Samreen Jamal, Nadeem Hafeez Butt
PURPOSE: Sturge-Weber syndrome (SWS), also known as encephalotrigeminal angiomatosis, is a condition which includes leptomeningeal hemangioma, facial angiomatosis or nevus flammeus, and ocular changes. SWS can lead to severe complications of anterior segment involving conjunctiva and eyelids, whereas posterior segment of the eye may also be affected by diffuse choroidal hemorrhages. This article was written with the objectives to determine the pathophysiology, diagnosis, and treatment of glaucoma associated with this rare and challenging disorder...
January 7, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28060076/epibulbar-plasmacytoma-masquerading-as-subconjunctival-hemorrhage-in-a-patient-with-multiple-myeloma
#3
Amanda Bradley, Amy Estes, Lane Ulrich, Dilip Thomas, David Gay
PURPOSE: We report a 75-year-old woman with a history of multiple myeloma immunoglobulin D (IgD) variant, who presented with an epibulbar plasmacytoma masquerading as a subconjunctival hemorrhage. METHODS: Magnetic resonance imaging of the brain and orbits with and without contrast was obtained and surgical biopsy of the subconjunctival lesion was performed; histopathology confirmed the diagnosis of plasmacytoma. RESULTS: Subconjunctival biopsy revealed a plasma cell neoplasm infiltrate in the episcleral layer...
February 2017: Cornea
https://www.readbyqxmd.com/read/28048976/repeat-episcleral-plaque-brachytherapy-clinical-outcomes-in-patients-treated-for-locally-recurrent-posterior-uveal-melanoma
#4
Benjamin King, Vanessa M Morales-Tirado, Henry G Wynn, Brad T Gao, Matthew T Ballo, Matthew W Wilson
PURPOSE: Report the outcomes of survival, local control, visual acuity and eye retention in patients treated with repeat episcleral plaque brachytherapy (EPBT) for locally recurrent posterior uveal melanoma (PUM). DESIGN: Retrospective, interventional case series METHODS: Setting: Institutional Patient Population: 1201 patients that underwent Iodine-125 (I-125) EPBT as primary treatment for PUM between 1985 and 2015 Inclusion criteria: Development of locally recurrent disease and retreatment with I-125 EPBT Observation Procedures: Clinical records review Main Outcome Measures: Visual acuity, Kaplan-Meier estimates of survival, local control, metastasis and loss of the eye over the duration of follow up RESULTS: Twenty-seven patients (13 men) met our inclusion criteria...
December 31, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28032234/the-emerging-role-of-interleukin-il-1-in-the-pathogenesis-and-treatment-of-inflammatory-and-degenerative-eye-diseases
#5
Claudia Fabiani, Jurgen Sota, Gian Marco Tosi, Rossella Franceschini, Bruno Frediani, Mauro Galeazzi, Donato Rigante, Luca Cantarini
Interleukin (IL)-1 plays a key role in the pathogenesis and thereafter in the search for specific treatments of different inflammatory and degenerative eye diseases. Indeed, an overactivity of IL-1 might be an initiating factor for many immunopathologic sceneries in the eye, as proven by the efficacy of the specific IL-1 blockade in different ocular diseases. For instance, the uveitis in monogenic autoinflammatory disorders, such as Blau syndrome and cryopyrin-associated periodic syndrome, or in complex polygenic autoinflammatory disorders, such as Behçet's disease, has been successfully treated with IL-1 blockers...
December 28, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/28028002/aqueous-outflow-a-continuum-from-trabecular-meshwork-to-episcleral-veins
#6
REVIEW
Teresia Carreon, Elizabeth van der Merwe, Ronald L Fellman, Murray Johnstone, Sanjoy K Bhattacharya
In glaucoma, lowered intraocular pressure (IOP) confers neuroprotection. Elevated IOP characterizes glaucoma and arises from impaired aqueous humor (AH) outflow. Increased resistance in the trabecular meshwork (TM), a filter-like structure essential to regulate AH outflow, may result in the impaired outflow. Flow through the 360° circumference of TM structures may be non-uniform, divided into high and low flow regions, termed as segmental. After flowing through the TM, AH enters Schlemm's canal (SC), which expresses both blood and lymphatic markers; AH then passes into collector channel entrances (CCE) along the SC external well...
December 24, 2016: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/27998698/ocular-complications-in-survivors-of-the-ebola-outbreak-in-guinea
#7
Esther Hereth He'bert, Mamadou Oury Bah, Jean François E'tard, Mamadou Saliou Sow, Serge Resnikoff, Christine Fardeau, Abdoulaye Toure', Alexis Niouma Ouendeno, Isaac Ceougna Sagno, Laura March, Suzanne Izard, Pierre Louis Lama, Moumié Barry, Eric Delaporte
PURPOSE: The Ebola outbreak of 2013-2016 severely affected West Africa and resulted in 2544 deaths and 1270 survivors in Guinea, the country where it began. This Ebola virus was the Zaire strain of the virus family Filoviridae. In this outbreak the case fatality rate was about 67%. The survivors, declared cured after two negative blood PCR results, face psychosocial disorders, rheumatic, ear-nose-throat, neurocognitive, and ophthalmological complications. The goal of this study was to detect and describe ocular complications afflicting these survivors and to observe their occurrence and recurrences...
December 17, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27987518/-clinical-characteristics-of-4-cases-of-scleritis-associated-with-systemic-lupus-erythematosus
#8
L Wang, Y Yang, Y Jia, H Miao, Y S Zhou, X Y Zhang
Episcleritis and scleritis are relatively rare ocular diseases, which are commonly associated with rheumatic diseases including systemic lupus erythematosus (SLE). To investigate clinical and laboratory features of SLE-associated episcleritis and scleritis, we now report 4 cases of inpatients who were diagnosed with episcleritis or scleritis secondary to SLE from September 2005 to July 2016 in the Department of Rheumatology and Immunology in Peking University People's Hospital. Demographic, clinical and laboratory characteristics were summarized together with the treatment regimen and the prognosis; the literature was reviewed...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27966834/outcomes-of-scleral-buckling-using-chandelier-endoillumination
#9
Yuntao Hu, Shancheng Si, Ke Xu, Huijin Chen, Liang Han, Xin Wang, Zhizhong Ma
PURPOSE: To report the results and complications of scleral buckling for the treatment of rhegmatogenous retinal detachment (RRD) using 25-gauge chandelier endoillumination. METHODS: A total of 61 patients (61 eyes) with RRD were treated with scleral buckling. For the sclera buckling procedure, a 25-gauge chandelier was inserted through the pars plana for intra-ocular illumination, and retinal tears were identified and treated with episcleral cryotherapy under surgical microscope...
December 14, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27930422/lacrimal-drainage-system-involvement-in-linear-scleroderma
#10
Swati Singh, Mohammad Javed Ali, Dilip Kumar Mishra, Milind N Naik
Linear scleroderma is a localized variety of scleroderma characterized by fibrotic areas of the dermis involving head region without systemic features. Ocular involvement has been sparsely reported in the form of episcleritis, dry eye, and uveitis. We describe a 42-year-old man with linear scleroderma, en coup de sabre type with associated nasolacrimal duct obstruction and prolonged dacryocystitis.
December 7, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27918224/ocular-autoimmune-systemic-inflammatory-infectious-study-oasis-report-1-epidemiology-and-classification
#11
Elizabeth J Chen, Muhammad Amir Bin Ismail, Helen Mi, Su Ling Ho, Wee Kiak Lim, Stephen C Teoh, Rupesh Agrawal
PURPOSE: To report the epidemiology and classification of ocular inflammation at a tertiary eye care center in Singapore. METHODS: Retrospective cohort study of the clinical records of consecutive new cases from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database from 2004-2015. RESULTS: A total of 2200 patients were studied from the OASIS database. The most common anatomic diagnosis was anterior uveitis (55.9%), posterior uveitis (17...
December 5, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27861307/epibulbar-plasmacytoma-masquerading-as-subconjunctival-hemorrhage-in-a-patient-with-multiple-myeloma
#12
Amanda Bradley, Amy Estes, Lane Ulrich, Dilip Thomas, David Gay
PURPOSE: We report a 75-year-old woman with a history of multiple myeloma immunoglobulin D (IgD) variant, who presented with an epibulbar plasmacytoma masquerading as a subconjunctival hemorrhage. METHODS: Magnetic resonance imaging of the brain and orbits with and without contrast was obtained and surgical biopsy of the subconjunctival lesion was performed; histopathology confirmed the diagnosis of plasmacytoma. RESULTS: Subconjunctival biopsy revealed a plasma cell neoplasm infiltrate in the episcleral layer...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27803867/prevalence-and-characteristics-of-ophthalmological-extra-intestinal-manifestations-in-chinese-patients-with-inflammatory-bowel-disease
#13
Ying-Chao Li, Wei-Zhi Li, Chang-Rui Wu, Yun Feng, Li Ren, Chen Mi, Yang Li
AIM: To investigate the prevalence of ophthalmological extra-intestinal manifestations (O-EIMs) in Chinese patients with inflammatory bowel disease (IBD) and to identify risk factors for the development of O-EIMs. METHODS: The study population consisted of Chinese patients with a definite diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) in a large teaching hospital between January 1995 and December 2014. Demographic and clinical characteristics of patients were extracted retrospectively...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27790380/aqueous-humor-outflow-structure-and-function-imaging-at-the-bench-and-bedside-a-review
#14
Alex S Huang, Chirayu Mohindroo, Robert N Weinreb
Anterior segment glaucoma clinical care and research has recently gained new focus because of novel imaging modalities and the advent of angle-based surgical treatments. Traditional investigation drawn to the trabecular meshwork now emphasizes the entire conventional aqueous humor outflow (AHO) pathway from the anterior chamber to the episcleral vein. AHO investigation can be divided into structural and functional assessments using different methods. The historical basis for studying the anterior segment of the eye and AHO in glaucoma is discussed...
August 2016: Journal of Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27761704/limbal-conjunctival-versus-amniotic-membrane-in-the-intraoperative-application-of-mitomycin-c-for-recurrent-pterygium-a-randomized-controlled-trial
#15
Rongxin Chen, Guofu Huang, Shu Liu, Wenfang Ma, Xiaofang Yin, Shiyou Zhou
PURPOSE: This study compared the outcomes of a limbal conjunctival autograft (LCAG) with those of an amniotic membrane graft (AMG) followed by intraoperative 0.02 % mitomycin C (MMC) to treat recurrent pterygium. METHODS: In this randomized controlled trial, ninety-six eyes with recurrent pterygium were enrolled and randomly allocated into two groups using a computer-generated random number table. Pterygium removal was followed by intraoperative 0.02 % MMC for 3 min and then either LCAG or AMG transplantation...
October 20, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27749794/can-peripheral-optical-coherence-tomography-b-scans-influence-the-surgeon-s-decision-on-episcleral-surgery
#16
Micol Alkabes, Domenico Massaro, Stefano Ranno, Paolo Nucci
PURPOSE: To describe the case of a young boy affected by a rhegmatogenous retinal redetachment in whom the use of peripheral optical coherence tomography led the vitreoretinal surgeon to treat the patient with an additional surgery instead of a "watchful waiting" strategy. METHODS: A 13-year-old boy was referred to the Vitreoretinal Department of the study institution affected by a macula-off rhegmatogenous retinal redetachment in his right eye secondary to a second blunt trauma...
October 3, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27746064/melanomalytic-glaucoma-secondary-to-iris-melanoma
#17
S Ajamil Rodanés, C García-Álvarez, M A Saornil Alvarez, F López-Lara, J M Frutos Baraja, M Quiñones
CLINICAL CASE: A 35-year-old male with unilateral ocular hypertension in the right eye (RE). Anterior segment examination of the RE showed a melanotic lesion. Intraocular pressure (IOP) was 40mmHg in RE. Gonioscopy revealed extension into the anterior chamber angle. Excisional biopsy was performed and consistent with iris melanoma and secondary melanomalytic glaucoma. Brachytherapy was performed as adjuvant therapy. DISCUSSION: In patients presenting with unilateral glaucoma and increased pigmentation in the trabecular meshwork, it is crucial to perform imaging studies...
October 13, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27726522/the-spectrum-of-uveitis-in-southern-vietnam
#18
Myhanh Nguyen, Jay Siak, Soon-Phaik Chee, Vo Quang Hong Diem
PURPOSE: To describe the pattern of uveitis among Vietnamese at two eye hospitals in Southern Vietnam. METHODS: We retrospectively reviewed the charts of 212 consecutive uveitis cases that presented to two eye hospitals in Ho Chi Minh City, Vietnam, from July 2011 to February 2015. The patients were identified from a database maintained by the hospitals. Patients with keratitis, episcleritis, orbital inflammation, post-surgical endophthalmitis, traumatic iritis, and corneal graft rejection were excluded...
October 11, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27717742/effect-of-intraocular-pressure-iop-and-choroidal-circulation-on-controlled-episcleral-drug-delivery-to-retina-vitreous
#19
Jie Li, Bifei Lan, Xiaoli Li, Shumao Sun, Ping Lu, Lingyun Cheng
Transscleral drug delivery may become a safe alternative to the intravitreal injection for chronic retinal diseases such as age-related macular degeneration or diabetic macular edema. However, the drug delivered onto the sclera subjects to vigorous clearance by episcleral and choroidal circulation; in addition, the penetration from episclera to retina needs to overcome counter-directional ocular fluid current driven by intraocular pressure (IOP) as well as unfavorable drug disposition exerted by drug transporters before the drug reach retina...
December 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27674991/prior-non-irradiative-focal-therapies-do-not-compromise-the-efficacy-of-delayed-episcleral-plaque-brachytherapy-epbrt-in-retinoblastoma
#20
J T Lucas, B Sharma, C A Billups, I Qaddoumi, T E Merchant, R C Brennan, M W Wilson
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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