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https://www.readbyqxmd.com/read/28536832/proteomic-profiling-reveals-crucial-retinal-protein-alterations-in-the-early-phase-of-an-experimental-glaucoma-model
#1
Fabian Anders, Julia Teister, Sebstian Funke, Norbert Pfeiffer, Franz Grus, Thanos Solon, Verena Prokosch
PURPOSE: Clinical glaucoma is difficult to assess in terms of molecular pathophysiology, prompting studies in experimental models of glaucoma. The purpose of this study was to investigate quantitative changes in retinal protein expression at the onset of experimental glaucoma in rats. Analyzing the proteome provides a suitable tool to decipher the pathophysiological processes in glaucomatous degeneration. METHODS: Thermic cauterization of episcleral veins was utilized to elevate the intraocular pressure in Sprague Dawley rats...
May 24, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28512422/acute-onset-ocular-hypotony-after-coronary-artery-bypass-surgery
#2
Sarah Farukhi Ahmed, Audrey Xi Tai, Mason Schmutz, John Combs, Sameh Mosaed
IMPORTANCE: The purpose of this case report is to evaluate risk factors associated with post-coronary artery bypass graft (CABG) ocular hypotony compared to post-CABG ischemic optic neuropathy. OBSERVATIONS: The patient described here is a single case at the University of California, Irvine Medical Center, from July 2016. This case demonstrates the rare incidence of acute post-CABG ocular hypotony and vision loss in a patient with prior history of optic atrophy...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28442689/wound-healing-and-glaucoma-surgery-modulating-the-scarring-process-with-conventional-antimetabolites-and-new-molecules
#3
Gábor Holló
Subconjunctival absorption of aqueous humor is an essential part of glaucoma filtration surgery. Mitomycin C (MMC) and 5-fluorouracil have been used to reduce postoperative episcleral fibrosis and scar formation in the filtering bleb area for more than 2 decades. Both antimetabolites have also been frequently injected before needling revision of failing filtering blebs. Recently, MMC was also tried in tube surgery and nonpenetrating filtering surgery, but its usefulness in these applications has not yet been determined...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28384305/intravitreal-injection-of-%C3%AE-crystallin-b2-improves-retinal-ganglion-cell-survival-in-an-experimental-animal-model-of-glaucoma
#4
Fabian Anders, Julia Teister, Aiwei Liu, Sebastian Funke, Franz H Grus, Solon Thanos, Harald D von Pein, Norbert Pfeiffer, Verena Prokosch
Purpose of this study was to investigate firstly specific proteomic changes within the retina in the course of an animal glaucoma model and to identify secondly new approaches for neuroprotective, therapeutic options in glaucoma by addressing those specific changes. Intraocular pressure was elevated through cauterization of episcleral veins in adult Sprague Dawley rats. Molecular and morphological changes were surveyed using mass spectrometry, optical coherence tomography as well as immunohistochemical cross section- and flat mount stainings...
2017: PloS One
https://www.readbyqxmd.com/read/28377140/early-outcomes-of-uveal-melanoma-treated-with-intraoperative-ultrasound-guided-brachytherapy-using-custom-built-plaques
#5
Anne W Tann, Bin S Teh, Sarah B Scarboro, Gary D Lewis, Maria E Bretana, Porshea C Croft, Yuval Raizen, E Brian Butler, Ryan S Kim, Patricia Chevez-Barrios, Amy C Schefler
PURPOSE: To report early outcomes of patients with uveal melanoma treated with Eye Physics iodine-125 episcleral plaque therapy using modern biopsy techniques and intraoperative ultrasound guidance at our institution. METHODS AND MATERIALS: A retrospective chart review was conducted for 48 consecutive patients with uveal melanoma who were treated with Eye Physics plaque brachytherapy performed by 1 ocular oncologist. All patients underwent intraoperative ultrasound for image guidance of plaque placement...
January 7, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28348913/a-rare-case-of-digital-ischemia-and-gangrene-in-anca-associated-vasculitis-with-review-of-the-literature
#6
Richard A Lau, Ramandeep Bains, Duminda Suraweera, Jane Ma, Emil R Heinze, Andrew L Wong, Philip J Clements
This paper describes one patient with Antineutrophil Cytoplasmic Antibody- (ANCA-) associated vasculitis who initially presented with multiple ischemic fingers and toes. On further evaluation, the patient was also found to have pulmonary-renal involvement and episcleritis. The diagnosis was supported with a positive cANCA (anti-proteinase 3) and a bronchoscopy consistent with diffuse alveolar hemorrhage. Although the patient refused a tissue biopsy, clinical presentation including nasal ulceration, sinus congestion, and epistaxis and anti-proteinase 3 antibody were more consistent with Granulomatosis with Polyangiitis (GPA) rather than Microscopic Polyangiitis (MPA) or Eosinophilic Granulomatosis with Polyangiitis (EGPA) based on the recently presented ACR/EULAR Provisional 2017 Classification Criteria for GPA (Luqmani et al...
2017: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/28348907/an-oct-study-of-anterior-nodular-episcleritis-and-scleritis
#7
Christos Christakopoulos
Anterior scleritis and episcleritis are a well-known presentation in tuberculosis. The case of a female patient with presumed tuberculous anterior scleritis and episcleritis is discussed in this article. Anterior segment OCT was efficient in diagnosis and evaluation of the therapeutic outcome. Antituberculosis chemotherapy was sufficient to achieve clinical remission.
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28340205/ocular-involvement-in-patients-with-spondyloarthritis
#8
Ana Beatriz Santos Bacchiega, Gustavo Guimarães Moreira Balbi, Manuella Lima Gomes Ochtrop, Francisco Assis de Andrade, Roger Abramino Levy, Xenofon Baraliakos
Ocular inflammatory diseases can present as isolated conditions but also as part of systemic inflammatory diseases. Anterior uveitis is closely related to SpA and shares the common genetic background of HLA-B27. Other ocular manifestations, such as episcleritis and scleritis, may also occur, although less frequently. Therefore, ocular involvement has been included as one of the important clinical features of SpA in the recently published classification criteria for axial and peripheral disease. However, there are a wide variety of aetiologies for ocular diseases and this must be considered in assessment of SpA...
March 18, 2017: Rheumatology
https://www.readbyqxmd.com/read/28337043/poststreptococcal-episcleritis
#9
Nicholas Young
This report describes the case of a patient presenting with an unusual poststreptococcal syndrome that featured episcleritis as a prominent manifestation. To my knowledge, this is the first time that poststreptococcal episcleritis has been described in the literature.
March 24, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28282736/ocular-inflammation-associated-with-polymyalgia-rheumatica-without-concomitant-giant-cell-arteritis-a-report-of-three-cases
#10
Takahiro Arai, Rie Tanaka, Toshikatsu Kaburaki
PURPOSE: We report three cases of ocular inflammation and polymyalgia rheumatica without concomitant giant-cell arteritis. METHODS: Report of three cases. RESULTS: Polymyalgia rheumatica onset was at a mean age of 66.7 years, and ocular inflammation, which developed 7-21 months later, was bilateral in all patients. Ocular inflammation presented as episcleritis, scleritis, or anterior uveitis, and it emerged during the tapering of low-dose prednisolone prescribed for polymyalgia rheumatica in all patients...
February 22, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28264102/mechanism-of-action-of-selective-laser-trabeculoplasty-and-predictors-of-response
#11
Vikas Gulati, Shan Fan, Bret J Gardner, Shane J Havens, Marie T Schaaf, Donna G Neely, Carol B Toris
Purpose: This study was designed to evaluate the changes in aqueous humor dynamics (AHD) produced by selective laser trabeculoplasty (SLT) and to explore if baseline AHD parameters are predictive of IOP response to SLT. Methods: Thirty-one consecutive subjects diagnosed with ocular hypertension or primary open-angle glaucoma scheduled to undergo SLT as their primary IOP-lowering therapy were enrolled in this prospective observational study. Subjects underwent baseline assessment of AHD in both eyes...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28249604/upregulation-of-the-endothelin-a-eta-receptor-and-its-association-with-neurodegeneration-in-a-rodent-model-of-glaucoma
#12
Nolan R McGrady, Alena Z Minton, Dorota L Stankowska, Shaoqing He, Hayden B Jefferies, Raghu R Krishnamoorthy
BACKGROUND: Primary open angle glaucoma is a heterogeneous group of optic neuropathies that results in optic nerve degeneration and a loss of retinal ganglion cells (RGCs) ultimately causing blindness if allowed to progress. Elevation of intraocular pressure (IOP) is the most attributable risk factor for developing glaucoma and lowering of IOP is currently the only available therapy. However, despite lowering IOP, neurodegenerative effects persist in some patients. Hence, it would be beneficial to develop approaches to promote neuroprotection of RGCs in addition to IOP lowering therapies...
March 1, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28240745/the-biological-and-prognostic-significance-of-angiotropism-in-uveal-melanoma
#13
Raymond L Barnhill, Mengliang Ye, Aude Batistella, Marc-Henri Stern, Sergio Roman-Roman, Rémi Dendale, Olivier Lantz, Sophie Piperno-Neumann, Laurence Desjardins, Nathalie Cassoux, Claire Lugassy
Angiotropism is a marker of extravascular migration of melanoma cells along vascular and other structures and a prognostic factor in cutaneous melanoma. Because of this biological and prognostic importance in cutaneous melanoma, angiotropism was studied in uveal melanoma (UM). This retrospective study performed at a single ocular oncology referral center included 89 patients from the study period 2006-2008. All patients were diagnosed with UM from the choroid and/or ciliary body. All patients underwent enucleation for prognostic purposes and definitive therapy...
February 27, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28237425/aqueous-angiography-in-living-nonhuman-primates-shows-segmental-pulsatile-and-dynamic-angiographic-aqueous-humor-outflow
#14
Alex S Huang, Meng Li, Diya Yang, Huaizhou Wang, Ningli Wang, Robert N Weinreb
PURPOSE: To evaluate the feasibility of safely performing aqueous angiography in intact eyes of living nonhuman primates (NHPs) for evaluating aqueous humor outflow and segmental patterns. DESIGN: Cross-sectional, observational study. SUBJECTS: Six nonhuman primates. METHODS: Aqueous angiography was performed in 6 nonhuman primates. After anesthesia, an anterior chamber (AC) maintainer was placed through a temporal 1-mm side-port wound...
February 22, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28207520/characterization-of-ocular-biometrics-and-aqueous-humor-dynamics-in-primary-angle-closure-suspects
#15
Li Guo, Yuan Deng, Li Fang, Chaoqi Liu, Tao Guo
Detailed characterizations of ocular biometrics and parameters of aqueous humor dynamics are lacking in primary angle closure suspect (PACS) patients. This study aims to characterize these parameters and compare them with age-matched healthy volunteers.Elderly healthy volunteers (60.6 ± 7.2 years of age, mean ± SD, n = 28) and PACS patients (64.1 ± 11.6 years, n = 30) completed the study. Parameters investigated were axial length (AXL), anterior chamber depth (ACD), anterior chamber volume (ACV), central cornea thickness (CCT), intraocular pressure (IOP), aqueous flow (Fa), outflow facility (C), episcleral venous pressure (EVP), and uveoscleral outflow (Fu)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28203193/recurrent-uveal-effusion-after-laser-iridotomy
#16
Hiroshi Sakai, Michiko Yonahara, Miyako Sakai
A 59-year-old woman was seen by an ophthalmologist for blurred vision, ocular pain, headache, and nausea. She was diagnosed with acute primary angle closure (APAC) and successfully treated with medications. Using ultrasound biomicroscopy (UBM), engorged episcleral vein was observed and small uveal effusion was diagnosed after laser peripheral iridotomy (LPI). The uveal effusion disappeared and was again diagnosed by UBM together with anterior segment inflammation with ocular pain. Iritis caused by LPI after APAC might be a cause of uveal effusion in this specific case...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28192845/-scleritis-progress-in-diagnosis-and-therapy
#17
D Pohlmann, U Pleyer
Inflammation of the sclera includes a wide range of morphological changes, which often occur in association with systemic diseases. While episcleritis is mainly harmless, scleritis often proceeds and is characterised by a destructive course. This may lead to important complications, that present as ulcerative keratitis, uveitis or secondary increases in intraocular pressure. As this form of inflammation is severe and there are often underlying diseases, this contribution focusses on differential diagnosis and current therapeutic approaches...
February 13, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28181930/recurrent-conjunctival-myofibrosarcoma-managed-with-triple-application-of-episcleral-brachytherapy
#18
Sean M Platt, Lynn Schoenfield, Surendra Basti, Paul J Bryar, John R Goldblum, Annapurna Singh, Arun D Singh
PURPOSE: To report a case of recurrent conjunctival myofibrosarcoma treated with wide surgical excision, cryotherapy, and triple sequential applications of episcleral brachytherapy. METHODS: A single case of recurrent conjunctival myofibrosarcoma. RESULTS: A 54-year-old man with a history of a renal transplant presented with a recurrent conjunctival tumor. Histopathologic diagnosis was established through immunohistochemistry. In total, 3 iodine radiation episcleral plaques were used over a period of 49 weeks...
May 2017: Cornea
https://www.readbyqxmd.com/read/28163118/local-failure-after-episcleral-brachytherapy-for-posterior-uveal-melanoma-patterns-risk-factors-and-management
#19
Claudine Bellerive, Hassan A Aziz, James Bena, Allan Wilkinson, John H Suh, Thomas Plesec, Arun D Singh
IMPORTANCE: A small percentage of patients with uveal melanoma will experience local recurrence following brachytherapy. An understanding of the recurrence patterns can improve early recognition and management of local treatment failure. OBJECTIVE: To evaluate the patterns, the risk factors and the management of recurrence following brachytherapy in patients with posterior uveal melanoma. DESIGN: Retrospective cohort study. SETTING: Multispecialty tertiary care center...
February 2, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28137903/subcorneal-pustular-dermatosis-and-episcleritis-associated-with-poorly-controlled-ulcerative-colitis
#20
Jeffrey J Wargo, Megan Adams, Julian Trevino
A man aged 56 years with a history of ulcerative colitis (UC) status postsubtotal colectomy was hospitalised with fevers, dry cough, eye redness and a new bloody, mucoid rectal discharge. 2 months prior to admission, the dermatologist had started him on dapsone for subcorneal pustular dermatosis but did not recognise that he had recently self-discontinued mesalamine enemas, inducing a flare of his UC. After a thorough inpatient evaluation, including flexible sigmoidoscopy, active UC involving the rectal stump was determined to be driving his dermatological and ophthalmological findings...
January 30, 2017: BMJ Case Reports
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