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https://www.readbyqxmd.com/read/29738013/atypical-posterior-scleritis-mimicking-choroidal-melanoma
#1
Heba M Alsharif, Saad A Al-Dahmash
We report a case of atypical posterior scleritis mimicking amelanotic choroidal melanoma. A 30-year-old healthy Filipino man, with a history of painless subacute loss of vision in his left eye over 5 months, was referred to our institute for further workup and management. On examination, visual acuity of the left eye was 20/200. Anterior segment examination yielded unremarkable results, with injected conjunctiva and quiet episcleral blood vessels, while fundus examination revealed non-pigmented nasal choroidal mass, with significant subretinal fluid resembling amelanotic choroidal melanoma...
May 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29718374/epidemiology-of-hypocomplementaemic-urticarial-vasculitis-anti-c1q-vasculitis
#2
Christopher Sjöwall, Thomas Mandl, Lillemor Skattum, Martin Olsson, Aladdin J Mohammad
Objectives: The aim was to describe the clinical characteristics and epidemiology of hypocomplementaemic urticarial vasculitis (HUV; anti-C1q vasculitis) in two geographically defined areas of Sweden. Methods: In the health-care districts surrounding Skåne University Hospital (mean population 950 560) and Linköping University Hospital (mean population 428 503), all incident cases of HUV residing within the study areas at the onset of disease were identified during the years 2000-15...
April 30, 2018: Rheumatology
https://www.readbyqxmd.com/read/29703835/fever-of-unknown-origin-bilateral-sensorineural-hearing-loss-with-canal-paresis-and-uveitis-with-iridocyclitis-and-episcleritis-a-case-of-cogan-s-syndrome
#3
Takashi Watari, Yasuharu Tokuda
No abstract text is available yet for this article.
April 27, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29694850/the-telopode-and-filopode-projecting-heterogeneous-stromal-cells-of-the-human-sclera-niche
#4
C E Petrea, Ş Crăiţoiu, A D Vrapciu, V S Mănoiu, M C Rusu
Telocytes (TCs) are stromal cells defined by the presence of long and slender prolongations (telopodes). They are a biologically and functionally heterogeneous population that has not been previously investigated in the sclera. The purpose of this study is to investigate the presence and characteristics of scleral telocytes through a combined immunohistochemical and transmission electron microscopy (TEM) study using samples from ten adult patients. Stromal cells with a TC-like morphology expressed CD34, CD45, CD105, vimentin and occasionally CD68 but were negative for collagen III, CD31, CD133, and CD146...
April 22, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29687155/takayasu-arteritis-in-childhood-misdiagnoses-at-disease-onset-and-associated-diseases
#5
Gleice Clemente, Clovis A Silva, Silvana B Sacchetti, Virginia P L Ferriani, Sheila K Oliveira, Flavio Sztajnbok, Blanca E R G Bica, André Cavalcanti, Teresa Robazzi, Marcia Bandeira, Maria Teresa Terreri
Juvenile-Takayasu arteritis (j-TA) is a difficult diagnosis and some patients develop uncommon manifestations and associated diseases that may contribute to the delayed diagnosis. Our aim was to identify the misdiagnoses, the associated diseases and the atypical manifestations observed in a j-TA Brazilian multicentre study. 71 children and adolescents who met the classification criteria for j-TA were included. The misdiagnoses, the associated diseases and the atypical manifestations were evaluated. 19 (26.8%) patients had misdiagnoses...
April 23, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29668916/extraintestinal-manifestations-in-vedolizumab-and-anti-tnf-treated-patients-with-inflammatory-bowel-disease
#6
Marla C Dubinsky, Raymond K Cross, William J Sandborn, Millie Long, Xue Song, Nianwen Shi, Yao Ding, Samantha Eichner, Brandee Pappalardo, Arijit Ganguli, Anthony Wang
Background: Extra-intestinal manifestations (EIMs) can impact morbidity in patients with inflammatory bowel diseases (IBD; Crohn's disease [CD] and ulcerative colitis [UC]). This study compared incidence rates of EIMs in patients with moderate to severe IBD receiving gut-selective vedolizumab (VDZ) vs those receiving systemic anti-tumor necrosis factor (anti-TNF) therapies. Methods: Adult IBD patients receiving VDZ or anti-TNFs were identified from the MarketScan claims database from September 28, 2012, through September 30, 2016...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29662677/auto-antibodies-against-p-q-and-n-type-voltage-dependent-calcium-channels-mimicking-frontotemporal-dementia
#7
Kyan Younes, Lauren A Lepow, Cynthia Estrada, Paul E Schulz
The behavioral variant of frontotemporal dementia is usually a sporadic and progressive neurodegenerative disorder. Here, we report the subacute onset of a frontotemporal dementia phenotype with a treatable etiology. The patient has a history of rheumatoid arthritis, episcleritis, and thyroid eye disease on immunosuppressive therapy. He experienced a rapid personality change, including inappropriate behavior, which suggested frontotemporal dementia. Results of imaging and neuropsychological testing also suggested frontotemporal dementia...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29656910/glycemic-control-is-an-important-modifiable-risk-factor-for-uveitis-in-patients-with-diabetes-a-retrospective-cohort-study-establishing-clinical-risk-and-ophthalmic-disease-burden
#8
Abdus Samad Ansari, Simon de Lusignan, William Hinton, Neil Munro, Simon Taylor, Andrew McGovern
AIM: To characterize the risk uveitis, scleritis or episcleritis in relation to diabetes, glycaemic control, and co-existence of retinopathy. METHODS: Using the Royal College of General Practitioners Research and Surveillance Centre database, we established the prevalence of acute uveitis and scleritis or episcleritis over a six-year period among populations without(n = 889,856) and with diabetes(n = 48,584). We evaluated the impact of glycaemic control on disease risk...
March 23, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29607552/pathophysiology-and-management-of-glaucoma-associated-with-phakomatoses
#9
REVIEW
Alisa T Thavikulwat, Deepak P Edward, Abdulrahman AlDarrab, Thasarat S Vajaranant
The phakomatoses, encephalotrigeminal angiomatosis (ETA; Sturge-Weber Syndrome), neurofibromatosis type 1 (NF1 or von Recklinghausen disease), Von Hippel-Lindau (VHL) disease, tuberous sclerosis (TSC), oculodermal melanocytosis (ODM), and phakomatosis pigmentovascularis are a group of neurocutaneous disorders that have characteristic systemic and ocular manifestations. Through many different mechanisms, they may cause glaucomatous damage of the optic nerve and subsequent vision loss varying from mild to severe...
April 1, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29605491/comparative-analysis-of-retinal-ganglion-cell-damage-in-three-glaucomatous-rat-models
#10
Wanjing Huang, Fangyuan Hu, Min Wang, Fengjuan Gao, Ping Xu, Chao Xing, Xinghuai Sun, Shenghai Zhang, Jihong Wu
Progressive retinal ganglion cell (RGC) death is the major cause of retinal nerve fiber layer thinning and visual field defects in glaucoma. The purpose of this study was to compare RGC damage in three commonly used glaucomatous rat models. These models were generated by (i) injection of paramagnetic microbeads into the anterior chamber; (ii) cauterization of three episcleral veins of the eye (EVC); and (iii) intravitreal injection of N-Methyl-D-Aspartate (NMDA). Intraocular pressure (IOP) was measured with a rebound tonometer at 6, 12, and 18 h; 1, 3, and 5 days; and 1, 2, 3, 4, 6, and 8 weeks...
March 29, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29590684/-morphological-and-quantitative-changes-in-retinal-and-optic-nerve-vessels-in-experimental-glaucoma-model-with-elevated-iop-for-7-weeks
#11
Carolina Mann, Fabian Anders, Hanhan Liu, Katrin Brockhaus, Aiwei Liu, Franz H Grus, Norbert Pfeiffer, Solon Thanos, Verena Prokosch
INTRODUCTION: Glaucoma is characterised by progressive loss of retinal ganglion cells and axons. Experimental research has concentrated on understanding the pathophysiological mechanisms involved in glaucomatous damage. It is still a matter of debate whether neurons or capillaries are primarily damaged by elevated intraocular pressure (IOP). The aim of this study was to detect IOP-induced vascular changes in the vessels of the optic nerve head and the main vessels of the retina in vivo...
March 28, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29580756/case-series-of-ocular-involvement-due-to-dengue-first-reported-cases-in-guatemala
#12
M A Carrillo-Soto
OBJECTIVE: Describe the ocular findings of a case series of 8 patients with a diagnosis of dengue. MATERIALS AND METHODS: Review of clinical records and interviews with patients during outpatient visits, after informed consent was obtained and following the ethical standards of the Helsinki declaration. The patients were diagnosed with diagnosis by IgM / IgG dengue serology in whom ocular involvement was identified, between January and October 2017 in Retinal-vascular clinic of the "Dr...
March 23, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29576892/amniotic-membrane-transplantation-in-surgical-treatment-of-conjunctival-melanoma-long-term-results
#13
Melis Palamar, Banu Yaman, Taner Akalın, Ayse Yağcı
Objectives: To investigate the long-term efficacy and results of surgical management of conjunctival melanoma reconstructed with amniotic membrane transplantation. Materials and Methods: Conjunctival melanoma in 10 patients (5 female, 5 male) was totally excised with adjunctive cryotherapy to the surgical margins, corneal epitheliectomy with absolute alcohol in cases of corneal involvement, lamellar sclerectomy in cases with episcleral involvement, and ocular surface grafting with cryopreserved amniotic membrane...
February 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29564803/the-impact-of-ocular-manifestations-of-rheumatoid-arthritis-on-the-health-related-quality-of-life-and-the-functional-ability-of-black-africans
#14
Richard Oluyinka Akintayo, Olufemi Oladipo Adelowo, Ochuko Egajifo, Rukayyah Abisoye Popoola, Gbenga Joshua Odunlami, Airenakho Emorinken, Babatunde Hakeem Olaosebikan
Objectives To determine the patterns, predictors and overall impact of ocular manifestations of rheumatoid arthritis (RA) on the health-related quality of life and disability index. METHODS: A total of 50 Nigerian patients with RA were studied. Full ocular evaluation was done to determine the presence of each defined ocular manifestation of RA. All patients completed the Medical Outcome Study 36-Item Short Form Health Survey (SF-36) and the Health Assessment Questionnaire-Disability Index (HAQ-DI) questionnaires...
March 21, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29563698/ocular-nonsuicidal-self-injury-in-a-teenager
#15
Francesco Comacchio, M Ricca, G Martini, V Cecchin, Maria Elisabetta Zannin
A 14-year-old male teen presented with unilateral episcleritis, unresponsive to topical and systemic corticosteroid therapy, without a history of ocular trauma or evidence for systemic diseases. The presence of foreign bodies in the conjunctival mucus of the hyperemic fornix has been noticed during one of the follow-up examinations. The toxicological analysis of conjunctival mucus revealed the presence of ethylene glycolmonomethyl ether and triethilene glicolebuthyl ether, used as solvents in nail polish removers and all-purpose cleaners...
January 2018: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29562055/urticaria-and-episcleritis-in-a-woman-with-chronic-cough
#16
Christina Dai, David Weinstein
No abstract text is available yet for this article.
March 21, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29551421/blue-nevi-of-the-ocular-surface-clinical-characteristics-pathologic-features-and-clinical-course
#17
Ibrahim Sayed-Ahmed, Juan Carlos Murillo, Pedro Monsalve, Jan Paul Ulloa, Maria P Fernandez, James Wong, George Elgart, Anat Galor, Sander R Dubovy, Carol L Karp
PURPOSE: Blue nevus is a melanocytic tumor that is commonly found in the skin. Extracutaneous presentations, including the ocular surface, are rare. As such, the purpose of this study was to characterize the clinical features and clinical course of congenital melanocytic tumor (blue nevus) of the conjunctiva. DESIGN: Retrospective, noncomparative case series. PARTICIPANTS: Twenty-one patients with 23 blue nevi of the ocular surface that were excised surgically between 2000 and 2016...
March 15, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29535566/functional-analysis-and-immunochemical-analyses-of-ca-2-homeostasis-related-proteins-expression-of-glaucoma-induced-retinal-degeneration-in-rats
#18
Ji-Yeon Lee, Su-Ja Oh
The retinal degeneration resulting from elevated intraocular pressure was evaluated through functional and morphological analyses, for better understanding of the pathophysiology of glaucoma. Ocular hypertension was induced via unilateral episcleral venous cauterization in rats. Experimental time was set at 1 and 3 days, and 1, 2, 4, and 8 weeks post-operation. Retinal function was analyzed using electroretinography. For morphological analysis, retinal tissues were processed for immunochemistry by using antibodies against the calcium-sensing receptor and calcium-binding proteins...
February 2018: Experimental Neurobiology
https://www.readbyqxmd.com/read/29517148/traumatic-phacocele-in-an-american-miniature-horse
#19
Kelly E Knickelbein, Mallory Stock, Sebastian E Carrasco, Christopher M Reilly, Mary E Lassaline
An 18-year-old American Miniature Horse mare was presented with a complaint of a scleral swelling affecting the right eye and a history of suspected trauma 6 weeks prior to evaluation. Clinical findings included severe blepharospasm, a bulbous swelling of the dorsotemporal bulbar conjunctiva, and phthisis bulbi. Ocular ultrasound was recommended but declined. Enucleation was elected for the blind, painful eye and was performed standing. Gross and histopathologic examinations of the globe were consistent with extrusion of the lens to the episcleral space, which is classified as a traumatic phacocele when associated with naturally occurring trauma...
March 8, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29503950/surgical-interventions-for-late-ocular-complications-of-relapsing-polychondritis
#20
Yuan He, Huifeng Liu, Zhi Ji, Binliang Zhu
Purpose: To report a case of surgical interventions for a patient with relapsing polychondritis who presented with late ocular complications. Observations: A 44-year-old male was diagnosed to have relapsing polychondritis on the basis of recurrent acute auricular chondritis, deformity of the ear, saddle nose deformity and painful nasal chondritis, acute ocular inflammation with conjunctivitis, episcleritis and keratouveitis, laryngotracheal chondritis, erythema nodosum in the skin, a history of polyarthritis, and abnormal blood examination findings...
April 2017: American Journal of Ophthalmology Case Reports
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