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Asthma, eosinophil, COPD, cough, sputum cell count, airway inflammation

Liesel D'silva, Nesreen Hassan, Hong-Yu Wang, Melanie Kjarsgaard, Ann Efthimiadis, Frederick E Hargreave, Parameswaran Nair
BACKGROUND: Sputum cell counts have identified inflammatory subtypes of bronchitis in relatively small numbers of subjects with asthma, chronic obstructive pulmonary disease (COPD) and chronic cough in research studies. The prevalence of different subtypes of bronchitis in routine clinical practice, however, has not been reported. OBJECTIVE: To examine the heterogeneity of bronchitis and its relationship to the severity of airflow obstruction. METHODS: A retrospective cross-sectional survey based on a computerized database of spontaneous or induced sputum cell counts examined in a large university tertiary respiratory outpatient clinic...
May 2011: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Dragoş Bumbăcea
Development of non-invasive markers of airway inflammation and remodelling is needed for diagnosis and monitoring of respiratory diseases, like asthma, COPD and interstitial lung diseases. This review is the first in a series evaluating the actual status of this process and is dedicated to induced sputum. We describe the methods of sputum induction, with special reference to efficiency and safety, especially in asthma patient. Methods of sputum processing are reviewed according to the end result: differential cell count, soluble markers assays, and also immunocytochemistry and in situ hybridisation...
October 2004: Pneumologia: Revista Societății Române de Pneumologie
P Rytilä, T Metso, T Petäys, A Sohlman, H Työlahti, P Kohonen-Jalonen, P Kiviniemi, T Haahtela
Prolonged cough is a common problem in patients seen in general practice. Using a simple method of sputum induction and processing of sputum samples, we determined whether eosinophilic airway inflammation could be a cause of undiagnosed prolonged cough. Eighty-two patients who had had cough for more than 1 month were enrolled into the study, in six primary healthcare centres. Patients with known pulmonary disease, including asthma or chronic obstructive pulmonary disease (COPD), or who were known to have another cause of cough, or to have recently suffered from a respiratory infection, were excluded...
January 2002: Respiratory Medicine
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