Elizabeth García-Gómez, Yadira Inés Gómez-Viais, Martin Mizael Cruz-Aranda, Luis Daniel Martínez-Razo, Christian Reyes-Mayoral, Lizeth Ibarra-González, Araceli Montoya-Estrada, Mauricio Osorio-Caballero, Otilia Perichart-Perera, Ignacio Camacho-Arroyo, Marco Cerbón, Enrique Reyes-Muñoz, Edgar Ricardo Vázquez-Martínez
Polycystic ovary syndrome (PCOS) is an endocrine disease associated with infertility and metabolic disorders in reproductive-aged women. In this study, we evaluated the expression of eight genes related to endometrial function and their DNA methylation levels in the endometrium of PCOS patients and women without the disease (control group). In addition, eight of the PCOS patients underwent intervention with metformin (1500 mg/day) and a carbohydrate-controlled diet (type and quantity) for three months. Clinical and metabolic parameters were determined, and RT-qPCR and MeDIP-qPCR were used to evaluate gene expression and DNA methylation levels, respectively...
April 6, 2023: International Journal of Molecular Sciences