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Insulin endometrium

Geoffrey C Kabat, Mimi Y Kim, Dorothy S Lane, Oleg Zaslavsky, Gloria Y F Ho, Juhua Luo, Wanda K Nicholson, Rowan T Chlebowski, Wendy E Barrington, Mara Z Vitolins, Xiaochen Lin, Simin Liu, Thomas E Rohan
Limited evidence suggests that hyperinsulinemia may contribute to the risk of breast, endometrial, and, possibly, ovarian cancer. The aim of this study was to assess the association of serum glucose and insulin with risk of these cancers in postmenopausal women, while taking into account potential confounding and modifying factors. We studied 21 103 women with fasting baseline insulin and glucose measurements in a subsample of the Women's Health Initiative. The subsample was composed of four studies within Women's Health Initiative with different selection and sampling strategies...
February 12, 2018: European Journal of Cancer Prevention
Aiwen Le, Zhong Hai Wang, Xiao Yun Dai, Tian Hui Xiao, Rong Zhuo, Baozhen Zhang, Zhonglin Xiao, Xiujun Fan
The aim of the present study was to investigate the effects of Icaritin on the proliferation and decidualization of endometrial stromal cells (ESCs). A total of 20 specimens of endometrium were collected during hysterectomy at the Gynecology Department of Shenzhen Nanshan People's Hospital (Shenzhen, China) between August 2014 and December 2015. The endometrium was digested with high concentrations of collagenase and DNase and filtered with meshes, and then the glandular epithelial and stromal cells were separated by the adhesion purification method...
December 2017: Experimental and Therapeutic Medicine
Silvana Rocio Ferreira, Alicia Beatriz Motta
BACKGROUND: The endometrium is one of the most important female reproductive organs. Polycystic ovarian syndrome (PCOS) is a reproductive and endocrine pathology that affect women of reproductive age. PCOS negatively affects the endometrium, leading to implantation failure and proliferative aberrations. METHODS: We conducted a search at the database using the following key words: endometrial steroid receptors, endometrium, uterine function, endometrium and PCOS, implantation window, implantation and PCOS, implantation markers, inflammation, oxidative stress...
December 5, 2017: Current Medicinal Chemistry
Sang Mi An, Jung Hye Hwang, Seulgi Kwon, Go Eun Yu, Da Hye Park, Deok Gyeong Kang, Tae Wan Kim, Hwa Chun Park, Jeongim Ha, Chul Wook Kim
Litter size is among the most important traits in swine breeding. However, information on the genetics of litter size in pigs is lacking. In this study, we identified single nucleotide polymorphisms (SNPs) in the insulin-like growth factor binding protein 2 and 3 (IGFBP2 and IGFBP3) genes in Berkshire pigs and analyzed their association with litter size traits. The IGFBP2 SNP was located on chromosome 15 intron 2 (455, A > T) and the IGFBP3 SNP was on chromosome 18 intron 2 (53, A > G). The AT type of IGFBP2 and the GG type of IGFBP3 had the highest values for all litter size traits including total number born (TNB), number of pigs born alive, and breeding value according to TNB...
December 4, 2017: Animal Biotechnology
Geoffrey C Kabat, Mimi Y Kim, Rowan T Chlebowski, Mara Z Vitolins, Sylvia Wassertheil-Smoller, Thomas E Rohan
PURPOSE: Obesity, which is commonly accompanied by dyslipidemia, is associated with an increased risk of certain cancers. However, the association of serum lipids with specific obesity-related cancers is unclear. METHODS: We examined the association of baseline lipids (total cholesterol, low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and triglycerides) with risk of developing seven obesity-related cancers in a subcohort of 24,208 participants in the Women's Health Initiative...
January 2018: Cancer Causes & Control: CCC
Yali Cheng, Qiaoying Lv, Bingying Xie, Bingyi Yang, Weiwei Shan, Chengcheng Ning, Bing Li, Liying Xie, Chao Gu, Xuezhen Luo, Xiaojun Chen, Qin Zhu
Unopposed estrogen stimulation and insulin resistance are known to play important roles in endometrial cancer (EC), but the interaction between these two factors and how they contribute to endometrial lesions are not completely elucidated. To investigate the endometrial transcriptome profile and the associated molecular pathway alterations, we established an ovariectomized C57BL/6 mouse model treated with subcutaneous implantation of 17-β estradiol (E2) pellet and/or high-fat diet (HFD) for 12 weeks to mimic sustained estrogen stimulation and insulin resistance...
November 13, 2017: Endocrine Connections
Lorena Oróstica, Paula García, Carolina Vera, Víctor García, Carmen Romero, Margarita Vega
Polycystic ovary syndrome (PCOS) affects not only ovarian functions but is also able to affect endometrium metabolism. Around 80% of women with PCOS are obese. High tumor necrosis factor (TNF)-α production and low adiponectin levels are characteristics of obesity. Interestingly, endometrium from obese women with PCOS presents an insulin-resistance condition, high TNF-α levels, and low adiponectin levels. However, TNF-α effect on molecules associated with insulin action in endometrial cells remains unclear...
January 1, 2017: Reproductive Sciences
I Martin Sheldon, James G Cronin, Mateusz Pospiech, Matthew L Turner
Bacterial infections of the uterus after parturition are ubiquitous in dairy cattle and often cause uterine disease, such as metritis or endometritis. However, the metabolic stress associated with milk production increases the risk of developing disease. Resolution of bacterial infections requires rapid and robust innate immune responses, which depend on host cell receptors recognizing pathogen-associated molecular patterns, such as lipopolysaccharide (LPS) from gram-negative bacteria. Here, we argue that metabolic stress impairs the inflammatory response to pathogens...
September 6, 2017: Journal of Dairy Science
Ryosuke Kobayashi, Jumpei Terakawa, Tsutomu Omatsu, Yupadee Hengjan, Tetsuya Mizutani, Yasushige Ohmori, Eiichi Hondo
BACKGROUND: The opening and closing of the implantation window is important for successful pregnancy in eutherians. The recent study demonstrated that the window of uterine receptivity was prepared by the sole action of progesterone in mice, but the mechanism to close the window remained to be elucidated. METHODS: The pregnant mice were ovariectomized on the evening on the third day of pregnancy with a single injection of medroxyprogesterone acetate to induce delayed implantation (DI)...
April 2017: Journal of Reproduction & Infertility
Jyun-Yuan Huang, Pei-Hsiu Yu, Yueh-Chun Li, Pao-Lin Kuo
BACKGROUND: Nucleotide-binding oligomerization domain (NACHT), leucine rich repeat (LRR) and pyrin domain (PYD) 7 containing protein, NLRP7, is a member of the NLR family which serves as innate immune sensors. Mutations and genetic variants of NLRP7 have been found in women with infertility associated conditions, such as recurrent hydatidiform mole, recurrent miscarriage, and preeclampsia. Decidualization of endometrial stromal cells is a hallmark of tissue remodeling to support embryo implantation and proper placental development...
August 15, 2017: Reproductive Biology and Endocrinology: RB&E
L Zhang, X-R Liu, J-Z Liu, Y-X Song, Z-Q Zhou, B-Y Cao
Proper HOXA10 expression was essential for endometrial receptivity what was crucial for successful embryo implantation in mammalian. This study confirmed that miR-182 regulated the expression levels of HOXA10 by binding to its 3' UTR, selectively downregulated HOXA10 in goat endometrial epithelium cells (gEECs) but not stromal cell (gESCs) in vitro. However, HOXA10 and miR-182 both up-expressed in the goat endometrium at gestational day 15 (D15) compared with gestational day 5 (D5), suggesting that there were some other factors regulated the expression of HOXA10 during the development of goat endometrium in vivo...
July 30, 2017: Reproduction in Domestic Animals, Zuchthygiene
Fabien Duval, Esther Dos Santos, Hadia Moindjie, Valérie Serazin, Nelly Swierkowski-Blanchard, François Vialard, Marie-Noëlle Dieudonné
Successful human embryo implantation requires a proper differentiation of endometrial stromal cells (ESCs) into decidual cells, during a process called decidualization. ESCs express specific molecules, as prolactin, insulin-like growth factor-binding protein-1 (IGFBP-1), and connexin-43. Decidual cells are also involved in the control of trophoblast invasion, by secreting various factors, as matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Adiponectin is an adipokine with insulin-sensitizing, anti-inflammatory, and anti-proliferative effects...
July 21, 2017: Journal of Molecular Endocrinology
Onder Koc, Safak Ozdemirici, Mustafa Acet, Ummugulsum Soyturk, Suleyman Aydin
The aim of this study was to investigate whether the expression levels of endometrial NFκB p65 differ between normal weight and overweight PCOS women and to compare them with BMI-matched control subjects without PCOS. The study group comprised 20 normal weight (BMI: 18.5-24.9 kg/m(2)) and 15 overweight PCOS women (BMI: 25-29.9 kg/m(2)) with infertility. Healthy fertile women without PCOS were recruited as the control group. The patients in the normal weight PCOS group and control group were age and BMI-matched...
June 15, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Emi Sato, Kentaro Nakayama, Kohei Nakamura, Noriyoshi Ishikawa, Masako Ishikawa, Toshiko Minamoto, Tomoka Ishibashi, Satoru Kyo
The paradigm of obesity, diabetes mellitus and insulin resistance possibly plays a critical role in the pathogenesis of endometrial cancer (EC). Impaired glucose tolerance and insulin resistance may play a direct or facilitating role in the neoplastic transformation of the endometrium, whereas antidiabetic therapy, particularly with metformin, has been suggested to inhibit EC progression. We herein present the case of a patient with EC who received metformin monotherapy due to complications after undergoing surgery...
March 2017: Molecular and Clinical Oncology
Runqin Li, Juan Wu, Junlin He, Yingxiong Wang, Xueqing Liu, Xuemei Chen, Chao Tong, Yubin Ding, Yan Su, Wenqi Chen, Chen Zhang, Rufei Gao
Previous studies have investigated the lower embryo implantation rates in women with polycystic ovary syndrome, obesity and type 2 diabetes, and specifically the association between the abnormal oocyte and embryo and hyperinsulinemia. The importance of hyperinsulinemia on maternal endometrium receptivity remains to be elucidated. The present study used a hyperinsulinemic mouse model to determine whether hyperinsulinemia may affect endometrial receptivity. An insulin intervention mouse model was first established...
May 2017: Molecular Medicine Reports
Jacqueline Deen, Thomas Moloney, David Burdon-Jones
Acanthosis nigricans (AN) is a dermatopathy associated with insulin-resistance, drugs, endocrine disorders, chromosomal abnormalities (benign AN), and neoplasia (malignant AN). Malignant AN (MAN) is a rare paraneoplastic skin syndrome most commonly associated with gastric adenocarcinoma and other intra-abdominal malignancies. We report the case of a 28-year-old female with AN associated with obesity, insulin resistance, and endometrial adenocarcinoma. Although rare, MAN is often an initial sign of malignancy and must trigger extensive investigation, particularly in patients with sudden development of possibly paraneoplastic dermatoses or in patients diagnosed with benign AN with any atypical features...
January 2017: Case Reports in Dermatology
Qiao-Ying Lv, Bing-Ying Xie, Bing-Yi Yang, Cheng-Cheng Ning, Wei-Wei Shan, Chao Gu, Xue-Zhen Luo, Xiao-Jun Chen, Zhen-Bo Zhang, You-Ji Feng
Background: Insulin resistance (IR) has been well studied in the initiation and development of endometrial endometrioid carcinoma (EEC). As yet, it has been largely neglected for estrogen sensitivity in local endometrium in hyperinsulinemia-induced systemic microenvironment. The aim of this study was to investigate the role of insulin in regulating estrogen sensitivity and explore the potential mechanisms in insulin-driven inflammatory microenvironment. Methods: We first investigated the effect of insulin on estradiol-driven endometrial cancer cells proliferation in vitro to address the roles of insulin in modulating estrogen sensitivity...
2017: Journal of Cancer
Wen-Jie Zhou, Xin-Xin Hou, Xiao-Qiu Wang, Da-Jin Li
Decidualization is an essential activity of the endometrium in pregnancy, but the molecular mechanisms involving the initiation and maintenance have not yet been clarified. In the present study, we examined the expression of fibroblast growth factor 7 (FGF7) in endometria, normal decidua, and abortion decidua from miscarriage by immunohistochemistry. We analyzed the expression of FGF7 and FGFR2 and the levels of phosphorylated extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinase (JNK) in endometrial stromal cells (ESCs), and decidual stromal cells (DSCs) from early pregnancy or miscarriage by In-Cell Western assay...
January 1, 2017: Reproductive Sciences
Di Wu, Fuminori Kimura, Luyi Zheng, Mitsuaki Ishida, Yoko Niwa, Kimiko Hirata, Akie Takebayashi, Akiko Takashima, Kentaro Takahashi, Ryoji Kushima, Guangmei Zhang, Takashi Murakami
BACKGROUND: Chronic endometritis (CE) is a continuous inflammation of uterine endometrium, and it is usually symptomless. As CE has been thought not to affect the reproductive status and general health of affected women, its significance has not been explored. However, recent studies have shown that CE is related with repeated implantation failures after in vitro fertilization-embryo transfer, unexplained infertility, and recurrent miscarriages. As decidua differentiates to support the implantation process and maintains the pregnancy, we hypothesized that CE may influence the process of decidualization...
March 4, 2017: Reproductive Biology and Endocrinology: RB&E
Mohamad N Shafiee, Nigel Mongan, Claire Seedhouse, Caroline Chapman, Suha Deen, Jafaru Abu, William Atiomo
INTRODUCTION: Women with polycystic ovary syndrome have a three-fold higher risk of endometrial cancer. Insulin resistance and hyperlipidemia may be pertinent factors in the pathogenesis of both conditions. The aim of this study was to investigate endometrial sterol regulatory element binding protein-1 gene expression in polycystic ovary syndrome and endometrial cancer endometrium, and to correlate endometrial sterol regulatory element binding protein-1 gene expression with serum lipid profiles...
May 2017: Acta Obstetricia et Gynecologica Scandinavica
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