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https://www.readbyqxmd.com/read/28938175/telomere-length-and-procedural-justice-predict-stress-reactivity-responses-to-unfair-outcomes-in-african-americans
#1
Todd Lucas, Jennifer Pierce, Mark A Lumley, Douglas A Granger, Jue Lin, Elissa S Epel
This experiment demonstrates that chromosomal telomere length (TL) moderates response to injustice among African Americans. Based on worldview verification theory - an emerging psychosocial framework for understanding stress - we predicted that acute stress responses would be most pronounced when individual-level expectancies for justice were discordant with justice experiences. Healthy African Americans (N=118; 30% male; M age=31.63years) provided dried blood spot samples that were assayed for TL, and completed a social-evaluative stressor task during which high versus low levels of distributive (outcome) and procedural (decision process) justice were simultaneously manipulated...
September 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28938026/hiv-exposed-seronegative-hesn-compared-to-hiv-infected-individuals-have-higher-frequencies-of-telomeric-killer-immunoglobulin-like-receptor-kir-b-motifs-contribution-of-kir-b-motif-encoded-genes-to-nk-cell-responsiveness
#2
Elise Jackson, Cindy Xinyu Zhang, Zahra Kiani, Irene Lisovsky, Benjamin Tallon, Alexa Del Corpo, Louise Gilbert, Julie Bruneau, Réjean Thomas, Pierre Côté, Benoit Trottier, Roger LeBlanc, Danielle Rouleau, Cécile Tremblay, Christos M Tsoukas, Jean-Pierre Routy, Xiaoyan Ni, Tsoarello Mabanga, Nicole F Bernard
Previously, we showed that Killer Immunoglobulin-like Receptor (KIR)3DS1 homozygotes (hmz) are more frequent in HIV exposed seronegative (HESN) than in recently HIV infected (HIV+) individuals. KIR3DS1 encodes an activating Natural Killer (NK) cell receptor (NKR). The link between KIR genotype and HIV outcomes likely arises from the function that NK cells acquire through expression of particular NKRs. An initial screen of 97 HESN and 123 HIV+ subjects for the frequency of KIR region gene carriage observed between-group differences for several telomeric KIR region loci...
2017: PloS One
https://www.readbyqxmd.com/read/28931225/persistent-herpesvirus-infections-and-telomere-attrition-over-3-years-in-the-whitehall-ii-cohort
#3
Jennifer B Dowd, Jos A Bosch, Andrew Steptoe, Bamini Jayabalasingham, Jue Lin, Robert Yolken, Allison E Aiello
The determinants of telomere attrition, a potential marker of cellular aging, are not well understood. Persistent herpesvirus infections including cytomegalovirus (CMV) infection may be particularly important for telomere dynamics via mechanisms such as inflammation, oxidative stress, and their impact on peripheral blood lymphocyte composition. This study examined the association of 4 human herpesviruses (CMV, herpes simplex virus type 1, human herpesvirus type 6, and Epstein-Barr virus) with change in leukocyte telomere length (LTL) over 3 years in 400 healthy individuals (aged 53-76 years) from the Whitehall II cohort...
September 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28930701/leukocyte-telomere-length-t-cell-composition-and-dna-methylation-age
#4
Brian H Chen, Cara L Carty, Masayuki Kimura, Jeremy D Kark, Wei Chen, Shengxu Li, Tao Zhang, Charles Kooperberg, Daniel Levy, Themistocles Assimes, Devin Absher, Steve Horvath, Alexander P Reiner, Abraham Aviv
Both leukocyte telomere length (LTL) and DNA methylation age are strongly associated with chronological age. One measure of DNA methylation age─ the extrinsic epigenetic age acceleration (EEAA)─ is highly predictive of all-cause mortality. We examined the relation between LTL and EEAA. LTL was measured by Southern blots and leukocyte DNA methylation was determined using Illumina Infinium HumanMethylation450 BeadChip in participants in the Women's Health Initiative (WHI; n=804), the Framingham Heart Study (FHS; n=909) and the Bogalusa Heart study (BHS; n=826)...
September 20, 2017: Aging
https://www.readbyqxmd.com/read/28928745/chronic-inflammation-in-immune-aging-role-of-pattern-recognition-receptor-crosstalk-with-the-telomere-complex
#5
REVIEW
Shyam Sushama Jose, Kamila Bendickova, Tomas Kepak, Zdenka Krenova, Jan Fric
Age-related decline in immunity is characterized by stem cell exhaustion, telomere shortening, and disruption of cell-to-cell communication, leading to increased patient risk of disease. Recent data have demonstrated that chronic inflammation exerts a strong influence on immune aging and is closely correlated with telomere length in a range of major pathologies. The current review discusses the impact of inflammation on immune aging, the likely molecular mediators of this process, and the various disease states that have been linked with immunosenescence...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28927584/longer-telomere-length-and-renal-cell-carcinoma
#6
EDITORIAL
Jozefina Casuscelli, A Ari Hakimi
No abstract text is available yet for this article.
September 16, 2017: European Urology
https://www.readbyqxmd.com/read/28927529/targeting-telomerase-and-telomeres-to-enhance-ionizing-radiation-effects-in-in-vitro-and-in-vivo-cancer-models
#7
REVIEW
F Berardinelli, E Coluzzi, A Sgura, A Antoccia
One of the hallmarks of cancer consists in the ability of tumor cells to divide indefinitely, and to maintain stable telomere lengths throughout the activation of specific telomere maintenance mechanisms (TMM). Therefore in the last fifteen years, researchers proposed to target telomerase or telomeric structure in order to block limitless replicative potential of cancer cells providing a fascinating strategy for a broad-spectrum cancer therapy. In the present review, we report in vitro and in vivo evidence regarding the use of chemical agents targeting both telomerase or telomere structure and showing promising antitumor effects when used in combination with ionizing radiation (IR)...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28926727/early-pregnancy-intrauterine-fetal-exposure-to-maternal-smoking-and-impact-on-fetal-telomere-length
#8
Hooman Mirzakhani, Immaculata De Vivo, J Steven Leeder, Roger Gaedigk, Carrie A Vyhlidal, Scott T Weiss, Kelan Tantisira
BACKGROUND: Reduced telomere length, or its accelerated attrition, has been implicated in aging, mortality, and several human diseases, including respiratory diseases. Age dependent manifestation of telomere-mediated disease during life span indicates the role of developmental stage in these diseases and highlights the importance of fetal developmental process in utero and at earlier life stages. Environmental determinants during developmental and later stages of life could affect telomere length...
September 14, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28925409/metabolic-and-genomic-adaptations-to-winter-fattening-in-a-primate-species-the-grey-mouse-lemur-microcebus-murinus
#9
J Terrien, M Gaudubois, D Champeval, V Zaninotto, L Roger, J F Riou, F Aujard
AIM: To understand the mechanisms underlying the development of metabolic changes leading to obesity remains a major world health issue. Among such mechanisms, seasonality is quite underestimated although it corresponds to the manifestation of extreme metabolic flexibility in response to a changing environment. Nevertheless, the changes induced by such flexibility are far to be understood, especially at the level of insulin signaling, genomic stability or inflammation. METHODS: Here, we investigated the metabolic regulations displayed by a seasonal primate species, the grey mouse lemur (Microcebus murinus) that exhibits pronounced changes in body mass during the 6-month winter season: a fattening period followed by a spontaneous fat loss, without ever reaching pathological stages...
August 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28919432/chronic-pain-and-telomere-length-in-community-dwelling-adults-findings-from-the-1999-2002-national-health-and-nutrition-examination-survey
#10
Alta M Steward, Julia D Morgan, Juan P Espinosa, Dennis C Turk, Kushang V Patel
Chronic pain is a common condition associated with psychological distress, functional impairments, and age-associated comorbidity. Preliminary studies, based on relatively small sample sizes, suggest that the combination of chronic pain and stress is associated with telomere shortening, a widely recognized marker of cellular aging. We sought to determine the cross-sectional association of chronic pain with telomere length in 7,816 community-dwelling adults ages 20 and older who participated in the 1999-2002 National Health and Nutrition Examination Survey...
September 12, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28915643/relationship-between-the-tert-tnip1-and-obfc1-genetic-polymorphisms-and-susceptibility-to-colorectal-cancer-in-chinese-han-population
#11
Chuang Li, Zixuan Zhao, Jun Zhou, Ying Liu, Hao Wang, Xinhan Zhao
Colorectal cancer (CRC) is one of the most common diseases worldwide, and telomere length has been reported correlate with CRC. This study aimed to investigate whether polymorphisms of telomere length related genes are associated with susceptibility to CRC in Chinese Han population. 11 SNPs from TERT, TNIP1 and OBFC1 genes were selected and genotyped, in addition odds ratio (OR) and 95% confidence intervals (CI) were used to evaluate association between the SNPs and CRC risk in 247 patients clinically and 300 controls in a Chinese Han population...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28910708/telomere-quantification-in-frontal-and-temporal-brain-tissue-of-patients-with-schizophrenia
#12
Hans C van Mierlo, Catharina G K Wichers, Yujie He, Marjolein A M Sneeboer, Timothy R D J Radstake, René S Kahn, Jasper C A Broen, Lot D de Witte
Recent imaging studies have suggested that accelerated aging occurs in schizophrenia. However, the exact cause of these findings is still unclear. In this study we measured telomere length, a marker for cell senescence, in gray and white matter brain tissue from the medial frontal gyrus (MFG) and superior temporal gyrus (STG) of 9 patients with schizophrenia and 11 controls. No alterations in telomere length were found in MFG gray and white matter and in STG gray matter. A significant reduction in telomere length was observed in STG white matter of patients with schizophrenia as compared to controls (fold change of -0...
September 7, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28904178/offspring-telomere-length-in-the-long-lived-alpine-swift-is-negatively-related-to-the-age-of-their-biological-father-and-foster-mother
#13
François Criscuolo, Sandrine Zahn, Pierre Bize
A growing body of studies is showing that offspring telomere length (TL) can be influenced by the age of their parents. Such a relationship might be explained by variation in TL at conception (gamete effect) and/or by alteration of early growth conditions in species providing parental care. In a long-lived bird with bi-parental care, the Alpine swift (Apus melba), we exchanged an uneven number of 2 to 4-day-old nestlings between pairs as part of a brood size manipulation. Nestling TL was measured at 50 days after hatching, which allowed investigation of the influence of the age of both their biological and foster parents on offspring TL, after controlling for the manipulation...
September 2017: Biology Letters
https://www.readbyqxmd.com/read/28900814/sub-fertile-sperm-cells-exemplify-telomere-dysfunction
#14
Tal Biron-Shental, Amir Wiser, Anat Hershko-Klement, Ofer Markovitch, Aliza Amiel, Arie Berkovitch
PURPOSE: The purpose of this study was to evaluate telomere homeostasis in sub-fertile compared to fertile human sperm. METHODS: This observational, comparative study included 16 sub-fertile men who required intracytoplasmic sperm injection and 10 fertile men. At least 100 sperm cells from each participant were assessed. Main outcome measures were telomere length and telomere aggregates. Telomerase RNA component (TERC) copy number and telomere capture were assessed using fluorescence in situ hybridization technique and human telomerase reverse transcriptase (hTERT) using immunohistochemistry...
September 13, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28900791/telomere-length-and-antioxidant-defense-associate-with-parasite-induced-retarded-growth-in-wild-brown-trout
#15
Janina Stauffer, Matthieu Bruneaux, Bineet Panda, Marko Visse, Anti Vasemägi, Petteri Ilmonen
Early growth conditions can have profound impacts on individuals' development, growth and physiology, with subsequent long-term consequences for individuals' fitness and life expectancy. Telomere length (TL) has been suggested to indicate both individual fitness and life expectancy in wide range of species, as the telomere attrition rate at early age can be accelerated due to exposure to various stressors, including parasites and inflammatory diseases, which increase production of reactive oxygen species (ROS) and influence antioxidant (AO) levels...
September 12, 2017: Oecologia
https://www.readbyqxmd.com/read/28893481/telomerase-based-anticancer-immunotherapy-and-vaccines-approaches
#16
REVIEW
Chahal Kailashiya, Hanjabam Barun Sharma, Jyotsna Kailashiya
Telomerase is a Reverse Transcriptase that maintains the telomere length. It is absent in most somatic cells but is found in stem cells, germ cells and around 90% of cancers. It plays a crucial role in developing and maintaining cancer cells. Telomerase, a HLA class-I antigen, is able to stimulate cell mediated immune response by inducing cytotoxic T-cells. This property of telomerase is being exploited in targeting cancers by host's own immune responses; stimulated by various Human Telomerase Reverse Transcriptase (hTERT) derived vaccines...
September 8, 2017: Vaccine
https://www.readbyqxmd.com/read/28892468/association-between-oxidative-stress-and-peripheral-leukocyte-telomere-length-in-patients-with-premature-coronary-artery-disease
#17
Ran Tian, Lei-Nan Zhang, Ting-Ting Zhang, Hai-Yu Pang, Lian-Feng Chen, Zhu-Jun Shen, Zhenyu Liu, Quan Fang, Shu-Yang Zhang
BACKGROUND Leukocyte telomere length (LTL) is regarded as a potential marker of biological aging. Oxidative stress plays a major role in the rate of telomeric DNA loss. The aim of this study was to explore whether the LTL was shorter in Chinese patients with premature coronary artery disease (PCAD) than in non-CAD controls and to determine the relationship between oxidative stress and LTL shortening in this population. MATERIAL AND METHODS Patients for coronary angiography were recruited. In total, 128 patients with PCAD and 128 non-CAD controls were enrolled...
September 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28890163/single-stem-cell-imaging-and-analysis-reveals-telomere-length-differences-in%C3%A2-diseased-human-and-mouse-skeletal-muscles
#18
Elisia D Tichy, David K Sidibe, Matthew T Tierney, Michael J Stec, Maryam Sharifi-Sanjani, Harish Hosalkar, Scott Mubarak, F Brad Johnson, Alessandra Sacco, Foteini Mourkioti
Muscle stem cells (MuSCs) contribute to muscle regeneration following injury. In many muscle disorders, the repeated cycles of damage and repair lead to stem cell dysfunction. While telomere attrition may contribute to aberrant stem cell functions, methods to accurately measure telomere length in stem cells from skeletal muscles have not been demonstrated. Here, we have optimized and validated such a method, named MuQ-FISH, for analyzing telomere length in MuSCs from either mice or humans. Our analysis showed no differences in telomere length between young and aged MuSCs from uninjured wild-type mice, but MuSCs isolated from young dystrophic mice exhibited significantly shortened telomeres...
August 30, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28889809/leukocyte-telomere-length-and-personality-associations-with-the-big-five-and-type-d-personality-traits
#19
D Schoormans, J E Verhoeven, J Denollet, L van de Poll-Franse, B W J H Penninx
Backgrounds Accelerated cellular ageing, which can be examined by telomere length (TL), may be an overarching mechanism underlying the association between personality and adverse health outcomes. This 6-year longitudinal study examined the relation between personality and leukocyte telomere length (LTL) across time among adults with a wide age-range. METHODS: Data from the Netherlands Study of Depression and Anxiety were used and included patients with a depression and/or anxiety disorder and healthy controls...
September 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28889049/the-potential-impact-of-biochemical-mediators-on-telomere-attrition-in-major-depressive-disorder-and-implications-for-future-study-designs-a-narrative-review
#20
REVIEW
Andrei Manoliu, Oliver G Bosch, Janis Brakowski, Annette B Brühl, Erich Seifritz
BACKGROUND: Major depressive disorder (MDD) has been proposed to represent a "disease of premature aging", which is associated with certain biomarkers of cellular ageing and numerous other age-related diseases. Over the last decade, telomere length (TL) arose as a surrogate for cellular aging. Recent data suggests that TL might be reduced in patients with MDD, however, results are still inconclusive. This might be explained by the lack of assessment of potential biochemical mediators that are directly associated with telomere shortening and frequently observed in patients with MDD...
August 15, 2017: Journal of Affective Disorders
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