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telomere length

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https://www.readbyqxmd.com/read/27922939/telomere-length-is-longer-in-women-with-late-maternal-age
#1
Erin Fagan, Fangui Sun, Harold Bae, Irma Elo, Stacy L Andersen, Joseph Lee, Kaare Christensen, Bharat Thyagarajan, Paola Sebastiani, Thomas Perls, Lawrence S Honig, Nicole Schupf
OBJECTIVE: Maternal age at birth of last child has been associated with maternal longevity. The aim of this study was to determine whether older women with a history of late maternal age at last childbirth had a longer leukocyte telomere length than those with maternal age at last childbirth of 29 years or less. METHODS: A nested case control study was conducted using data from the Long Life Family Study. Three hundred eighty-seven women who gave birth to at least one child and lived to the top fifth percentile of their birth cohort, or died before the top fifth percentile of their birth cohort died, but were at least 70 years old, were studied...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922633/variable-telomere-length-across-post-mortem-human-brain-regions-and-specific-reduction-in-the-hippocampus-of-major-depressive-disorder
#2
F Mamdani, B Rollins, L Morgan, R M Myers, J D Barchas, A F Schatzberg, S J Watson, H Akil, S G Potkin, W E Bunney, M P Vawter, P A Sequeira
No abstract text is available yet for this article.
December 6, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27922610/the-origin-of-oxidized-guanine-resolves-the-puzzle-of-oxidation-induced-telomere-length-alterations
#3
Jaya Sarkar, Yie Liu
No abstract text is available yet for this article.
December 6, 2016: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/27922187/tomentosin-induces-telomere-shortening-and-caspase-dependant-apoptosis-in-cervical-cancer-cells
#4
Nawel Merghoub, Hassan El Btaouri, Laila Benbacer, Saïd Gmouh, Chantal Trentesaux, Bertrand Brassart, Mohammed Attaleb, Claudie Madoulet, Thomas Wenner, Saaid Amzazi, Hamid Morjani, Mohamed El Mzibri
Tomentosin, a natural sesquiterpene lactone purified from of Inula viscosa L., was investigated for its anti-proliferative, telomere shortening and apoptotic effects on human cervical cancer HeLa and SiHa cell lines. Tomentosin was found to inhibit the growth of SiHa and HeLa cell lines in dose and time-dependent manner (IC50 values of 7.10 ± 0.78µM and 5.87 ± 0.36µM, respectively after 96h of treatment). As evidenced by TTAGGG telomere length assay, tomentosin target specifically the telomeric overhang lengthening...
December 6, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27920200/telomere-length-and-pancreatic-cancer-risk-breaking-down-the-evidence
#5
Eric J Duell
No abstract text is available yet for this article.
December 5, 2016: Gut
https://www.readbyqxmd.com/read/27918657/telomere-length-in-elite-athletes
#6
Carlos A Muniesa, Zoraida Verde, Germán Diaz-Ureña, Catalina Santiago, Fernando Gutiérrez, Enrique Díaz, Félix Gómez-Gallego, Helios Pareja-Galeano, Luisa Soares-Miranda, Alejandro Lucia
PURPOSE: Growing evidence suggests that regular, moderate-intensity physical activity is associated with an attenuation of leucocyte telomere length (LTL) shortening. However, more controversy exists regarding higher exercise loads, such as those imposed by elite sports participation. METHODS: We have investigated LTL differences between young elite athletes (n=61, 54% men, aged [mean±SD] 27.2±4.9 years) and their healthy non-smoker, physically inactive controls (n=64, 52% men, 28...
December 5, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27918544/a-balance-between-elongation-and-trimming-regulates-telomere-stability-in-stem-cells
#7
Teresa Rivera, Candy Haggblom, Sandro Cosconati, Jan Karlseder
Telomere length maintenance ensures self-renewal of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs); however, the mechanisms governing telomere length homeostasis in these cell types are unclear. Here, we report that telomere length is determined by the balance between telomere elongation, which is mediated by telomerase, and telomere trimming, which is controlled by XRCC3 and Nbs1, homologous recombination proteins that generate single-stranded C-rich telomeric DNA and double-stranded telomeric circular DNA (T-circles), respectively...
December 5, 2016: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/27913192/the-cellular-protein-nucleolin-preferentially-binds-long-looped-g-quadruplex-nucleic-acids
#8
Sara Lago, Elena Tosoni, Matteo Nadai, Manlio Palumbo, Sara N Richter
BACKGROUND: G-quadruplexes (G4s) are four-stranded nucleic acid structures that form in G-rich sequences. Nucleolin (NCL) is a cellular protein reported for its functions upon G4 recognition, such as induction of neurodegenerative diseases, tumor and virus mechanisms activation. We here aimed at defining NCL/G4 binding determinants. METHODS: Electrophoresis mobility shift assay was used to detect NCL/G4 binding; circular dichroism to assess G4 folding, topology and stability; dimethylsulfate footprinting to detect G bases involved in G4 folding...
November 30, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27911971/commentary-on-association-between-maternal-perceived-psychological-stress-and-fetal-telomere-length
#9
Michael S Cardwell
No abstract text is available yet for this article.
December 2016: Southern Medical Journal
https://www.readbyqxmd.com/read/27911970/association-between-maternal-perceived-psychological-stress-and-fetal-telomere-length
#10
Hamisu M Salihu, Lindsey M King, Chiaka Nwoga, Arnut Paothong, Anupam Pradhan, Phillip J Marty, Rana Daas, Valerie E Whiteman
OBJECTIVE: Our study aimed to investigate the association between maternal-perceived psychological stress and fetal telomere length. METHODS: We recruited women in labor upon hospital delivery admission. Based on responses to the Perceived Stress Scale, we categorized participants as having "high," "normal," or "low" perceived stress. We collected umbilical cord blood samples (N = 71) and isolated genomic DNA from cord blood leukocytes using quantitative polymerase chain reaction...
December 2016: Southern Medical Journal
https://www.readbyqxmd.com/read/27905522/circulating-cell-free-dna-telomere-length-and-bilirubin-in-the-vienna-active-ageing-study-exploratory-analysis-of-a-randomized-controlled-trial
#11
Anela Tosevska, Bernhard Franzke, Marlene Hofmann, Immina Vierheilig, Barbara Schober-Halper, Stefan Oesen, Oliver Neubauer, Barbara Wessner, Karl-Heinz Wagner
Telomere length (TL) in blood cells is widely used in human studies as a molecular marker of ageing. Circulating cell-free DNA (cfDNA) as well as unconjugated bilirubin (UCB) are dynamic blood constituents whose involvement in age-associated diseases is largely unexplored. To our knowledge, there are no published studies integrating all three parameters, especially in individuals of advanced age. Here we present a secondary analysis from the Vienna Active Aging Study (VAAS), a randomized controlled intervention trial in institutionalized elderly individuals (n = 101)...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27902754/how-do-growth-and-sibling-competition-affect-telomere-dynamics-in-the-first-month-of-life-of-long-lived-seabird
#12
Yuichi Mizutani, Yasuaki Niizuma, Ken Yoda
Telomeres are nucleotide sequences located at the ends of chromosomes that promote genome stability. Changes in telomere length (dynamics) are related to fitness or life expectancy, and telomere dynamics during the development phase are likely to be affected by growth and stress factors. Here, we examined telomere dynamics of black-tailed gull chicks (Larus crassirostris) in nests with and without siblings. We found that the initial telomere lengths of singletons at hatching were longer than those of siblings, indicating that singletons are higher-quality chicks than siblings in terms of telomere length...
2016: PloS One
https://www.readbyqxmd.com/read/27899638/structure-and-folding-of-the-tetrahymena-telomerase-rna-pseudoknot
#13
Darian D Cash, Juli Feigon
Telomerase maintains telomere length at the ends of linear chromosomes using an integral telomerase RNA (TER) and telomerase reverse transcriptase (TERT). An essential part of TER is the template/pseudoknot domain (t/PK) which includes the template, for adding telomeric repeats, template boundary element (TBE), and pseudoknot, enclosed in a circle by stem 1. The Tetrahymena telomerase holoenzyme catalytic core (p65-TER-TERT) was recently modeled in our 9 Å resolution cryo-electron microscopy map by fitting protein and TER domains, including a solution NMR structure of the Tetrahymena pseudoknot...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27898678/leukocyte-telomere-length-in-relation-to-17-biomarkers-of-cardiovascular-disease-risk-a-cross-sectional-study-of-us-adults
#14
David H Rehkopf, Belinda L Needham, Jue Lin, Elizabeth H Blackburn, Ami R Zota, Janet M Wojcicki, Elissa S Epel
BACKGROUND: Leukocyte telomere length (LTL) is a putative biological marker of immune system age, and there are demonstrated associations between LTL and cardiovascular disease. This may be due in part to the relationship of LTL with other biomarkers associated with cardiovascular disease risk. However, the strength of associations between LTL and adiposity, metabolic, proinflammatory, and cardiovascular biomarkers has not been systematically evaluated in a United States nationally representative population...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27891759/sociodemographic-correlates-and-family-aggregation-of-leukocyte-telomere-length-in-adults-and-children-from-mesoamerica
#15
Kerry S Flannagan, Erica C Jansen, Laura S Rozek, Katie M Rentschler, Ana Victoria Roman, Manuel Ramirez-Zea, Eduardo Villamor
OBJECTIVE: Telomere length is a biomarker of cumulative stress and inflammation related to chronic disease risk. We examined the associations of leukocyte telomere length (LTL) with sociodemographic and anthropometric variables and estimated LTL family aggregation in Central America, a region with a high burden of chronic disease where LTL has not been studied. METHODS: We conducted a cross-sectional study of 174 school age children and their parents in the capital cities of Belize, Honduras, Nicaragua, Costa Rica, Panama, and the city of Tuxtla-Gutierrez in Mexico...
November 28, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/27891221/brood-size-moderates-associations-between-relative-size-telomere-length-and-immune-development-in-european-starling-nestlings
#16
Daniel Nettle, Clare Andrews, Sophie Reichert, Tom Bedford, Annie Gott, Craig Parker, Claire Kolenda, Carmen Martin-Ruiz, Pat Monaghan, Melissa Bateson
For young birds in a nest, body size may have implications for other aspects of development such as telomere length and immune function. However, it is possible to predict associations in either direction. On the one hand, there may be trade-offs between growth and telomere maintenance, and growth and investment in immune function, suggesting there will be negative correlations. On the other hand, relatively larger individuals might be advantaged in competition with their nest-mates, allowing them to garner more resources overall, leading to positive correlations...
November 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27889913/long-term-melatonin-treatment-delays-ovarian-aging
#17
Hiroshi Tamura, Mai Kawamoto, Shun Sato, Isao Tamura, Ryo Maekawa, Toshiaki Taketani, Hiromi Aasada, Eiichi Takaki, Akira Nakai, Russel J Reiter, Norihiro Sugino
Ovarian aging is characterized by gradual declines in oocyte quantity and quality. Melatonin is considered an anti-aging agent due to its cytoprotective actions as an antioxidant. The present study examined whether long-term melatonin treatment would delay ovarian aging in mice. Female ICR mice (10 weeks old) were given melatonin-containing water (100 μg/ml; melatonin) or water only until 43 weeks of age. Their oocytes were recovered from the oviduct, and in vitro fertilization was performed. The ovaries were used for a histological analysis of the number of follicles...
November 27, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27889357/the-impact-of-overweight-obesity-duration-and-physical-activity-on-telomere-length-an-application-of-the-watch-paradigm
#18
Scott J Dankel, Jeremy P Loenneke, Paul D Loprinzi
INTRODUCTION: Physical activity may protect against health consequences associated with obesity, yet less is known on how the duration of obesity alters this association, specifically as it relates to leukocyte telomere length. METHODS: The 1999-2002 NHANES was used to place individuals into 6 mutually exclusive groups based on physical activity status and weight status/duration. RESULTS: All active individuals, except for those overweight/obese for longer durations, were associated with longer telomeres in comparison to sedentary individuals...
November 23, 2016: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27889084/linking-telomere-regulation-to-stem-cell-pluripotency
#19
REVIEW
Lin Liu
Embryonic stem cells (ESCs), somatic cell nuclear transfer ESCs, and induced pluripotent stem cells (iPSCs) represent the most studied group of PSCs. Unlimited self-renewal without incurring chromosomal instability and pluripotency are essential for the potential use of PSCs in regenerative therapy. Telomere length maintenance is critical for the unlimited self-renewal, pluripotency, and chromosomal stability of PSCs. While telomerase has a primary role in telomere maintenance, alternative lengthening of telomere pathways involving recombination and epigenetic modifications are also required for telomere length regulation, notably in mouse PSCs...
November 23, 2016: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/27883035/telomeres-are-elongated-in-older-individuals-in-a-hibernating-rodent-the-edible-dormouse-glis-glis
#20
Franz Hoelzl, Steve Smith, Jessica S Cornils, Denise Aydinonat, Claudia Bieber, Thomas Ruf
Telomere shortening is thought to be an important biomarker for life history traits such as lifespan and aging, and can be indicative of genome integrity, survival probability and the risk of cancer development. In humans and other animals, telomeres almost always shorten with age, with more rapid telomere attrition in short-lived species. Here, we show that in the edible dormouse (Glis glis) telomere length significantly increases from an age of 6 to an age of 9 years. While this finding could be due to higher survival of individuals with longer telomeres, we also found, using longitudinal measurements, a positive effect of age on the rate of telomere elongation within older individuals...
November 24, 2016: Scientific Reports
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