keyword
MENU ▼
Read by QxMD icon Read
search

telomere length

keyword
https://www.readbyqxmd.com/read/28226264/leukocyte-telomere-length-in-hispanic-schizophrenia-patients-under-treatment-with-olanzapine
#1
Nancy Monroy-Jaramillo, Yaneth Rodríguez-Agudelo, Luis Carlos Aviña-Cervantes, David L Roberts, Dawn I Velligan, Consuelo Walss-Bass
Different lines of evidence indicate that patients with schizophrenia (SZ) exhibit accelerated aging. Leukocyte telomere length (TL), an aging marker, is associated with age-related and chronic pathologies, including schizophrenia. We analyzed leukocyte TL in 170 SZ patients of Hispanic ancestry grouped based on antipsychotic treatment, compared to 126 matched controls. The group under treatment with atypical antipsychotics was further subdivided according to the risk of medication to cause metabolic syndrome (MetS)...
February 10, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28224765/dysregulation-of-telomere-lengths-and-telomerase-activity-in-myelodysplastic-syndrome
#2
Hee Sue Park, Jungeun Choi, Cha Ja See, Jung Ah Kim, Si Nae Park, Kyongok Im, Sung Min Kim, Dong Soon Lee, Sang Mee Hwang
BACKGROUND: Telomere shortening is thought to be involved in the pathophysiology of myeloid malignancies, but telomere lengths (TL) during interphase and metaphase in hematopoietic malignancies have not been analyzed. We aimed to assess the TLs of interphase and metaphase cells of MDS and telomerase activity (TA) and to find out prognostic significances of TL and TA. METHODS: The prognostic significance of TA by quantitative PCR and TL by quantitative fluorescence in situ hybridization (QFISH) of interphase nuclei and metaphase chromosome arms of bone marrow cells from patients with MDS were evaluated...
May 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28222672/long-leukocyte-telomere-length-in-prostate-cancer-patients-at-diagnosis-is-associated-with-poor-metastasis-free-and-cancer-specific-survival
#3
Ulrika Svenson, Göran Roos, Pernilla Wikström
Previous studies have suggested that leukocyte telomere length is associated with risk of developing prostate cancer. Investigations of leukocyte telomere length as a prognostic factor in prostate cancer are, however, lacking. In this study, leukocyte telomere length was investigated both as a risk marker, comparing control subjects and patient risk groups (based on serum levels of prostate-specific antigen, tumor differentiation, and tumor stage), and as a prognostic marker for metastasis-free and cancer-specific survival...
February 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28221367/transcriptomic-analyses-and-leukocyte-telomere-length-measurement-in-subjects-exposed-to-severe-recent-stressful-life-events
#4
N Lopizzo, S Tosato, V Begni, S Tomassi, N Cattane, M Barcella, G Turco, M Ruggeri, M A Riva, C M Pariante, A Cattaneo
Stressful life events occurring in adulthood have been found able to affect mood and behavior, thus increasing the vulnerability for several stress-related psychiatric disorders. However, although there is plenty of clinical data supporting an association between stressful life events in adulthood and an enhanced vulnerability for psychopathology, the underlying molecular mechanisms are still poorly investigated. Thus, in this study we performed peripheral/whole-genome transcriptomic analyses in blood samples obtained from 53 adult subjects characterized for recent stressful life events occurred within the previous 6 months...
February 21, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28218725/treating-cancer-by-targeting-telomeres-and-telomerase
#5
REVIEW
Marko Ivancich, Zachary Schrank, Luke Wojdyla, Brandon Leviskas, Adijan Kuckovic, Ankita Sanjali, Neelu Puri
Telomerase is expressed in more than 85% of cancer cells. Tumor cells with metastatic potential may have a high telomerase activity, allowing cells to escape from the inhibition of cell proliferation due to shortened telomeres. Human telomerase primarily consists of two main components: hTERT, a catalytic subunit, and hTR, an RNA template whose sequence is complimentary to the telomeric 5'-dTTAGGG-3' repeat. In humans, telomerase activity is typically restricted to renewing tissues, such as germ cells and stem cells, and is generally absent in normal cells...
February 19, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28217990/telomerase-activity-detection-with-amplification-free-single-molecule-stochastic-binding-assay
#6
Xin Su, Zehao Li, Xinzhong Yan, Lei Wang, Xu Zhou, Lin Wei, Lehui Xiao, Changyuan Yu
Since the elongation of telomeres is associated with tumorigenesis, it is of great interest to develop rapid and high-confidence telomerase activity detection methods for disease diagnosis. Currently, amplification based strategies have been extensively explored for telomerase detection in vitro and in vivo. However, amplification typically associated with poor reproducibility and high background which hamper their further applications particularly for real sample assay. Here, we demonstrated a new amplification-free single molecule imaging method for telomerase activity detection in vitro based on nucleic acid stochastic binding with total internal reflection fluorescence microscopy (TIRFM)...
February 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28213353/the-telomere-associated-tzap-protein-limits-telomere-length
#7
(no author information available yet)
TZAP binds preferentially to long telomeres and promotes telomere trimming.
February 17, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28209595/prediagnosis-leukocyte-telomere-length-and-risk-of-ovarian-cancer
#8
Meng Yang, Jennifer Prescott, Elizabeth M Poole, Megan S Rice, Laura D Kubzansky, Annika Idahl, Eva Lundin, Immaculata De Vivo, Shelley S Tworoger
Background: The associations between telomere length and cancer risk are equivocal, and none have examined the association between prediagnosis leukocyte telomere length (LTL) and the risk of developing ovarian cancer.Methods: We prospectively measured LTL collected from 442 ovarian cancer cases and 727 controls in the Nurses' Health Studies and the Northern Sweden Health and Disease Study. Cases were matched to one or two controls on age, menopausal status, and date of blood collection. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression...
February 16, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28205383/association-between-leukocyte-telomere-length-and-angiogenic-cytokines-in-knee-osteoarthritis
#9
Thitiya Poonpet, Natthaphon Saetan, Aree Tanavalee, Vajara Wilairatana, Pongsak Yuktanandana, Sittisak Honsawek
AIM: The aims of this study were to compare leukocyte relative telomere length (RTL) in knee osteoarthritis (OA) patients and healthy controls and to investigate associations between plasma angiogenic cytokine concentrations and leukocyte RTL. METHOD: Eighty knee OA patients and 60 age-matched controls were enrolled. Leukocyte RTL was assessed using real-time quantitative polymerase chain reaction (qPCR). Angiogenic cytokines were measured by a multiplex immunoassay...
February 16, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28197807/telomere-length-in-the-gastric-mucosa-after-helicobacter-pylori-eradication-and-its-potential-role-in-the-gastric-carcinogenesis
#10
Tomomitsu Tahara, Sayumi Tahara, Tetsuya Tuskamoto, Noriyuki Horiguchi, Tomohiko Kawamura, Masaaki Okubo, Takamitsu Ishizuka, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Makoto Kuroda, Naoki Ohmiya
The molecular mechanisms of gastric carcinogenesis after Helicobacter pylori (H. pylori) eradication remain unclear. We examined the telomere length of gastric mucosa samples after successful H. pylori eradication in patients without and those with gastric cancer. Telomere length was measured by the real-time PCR among four different groups of biopsies: gastric body from subjects without history of H. pylori infection (Hp-: n = 23), gastric body from cancer-free subjects after H. pylori eradication (cancer-free body: n = 24), gastric body from early gastric cancer patients diagnosed after H...
February 14, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/28196871/identification-of-a-transcriptional-activation-domain-in-yeast-repressor-activator-protein-1-rap1-using-an-altered-dna-binding-specificity-variant
#11
Amanda N Johnson, P Anthony Weil
Repressor Activator Protein 1 (Rap1) performs multiple vital cellular functions in the budding yeast Saccharomyces cerevisiae. These include regulation of telomere length, transcriptional repression of both telomere-proximal genes and the silent mating type loci, and transcriptional activation of hundreds of mRNA-encoding genes, including the highly transcribed ribosomal protein- and glycolytic enzyme-encoding genes. Studies of the contributions of Rap1 to telomere length regulation and transcriptional repression have yielded significant mechanistic insights...
February 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28193312/leukocyte-and-skeletal-muscle-telomere-length-and-body-composition-in-monozygotic-twin-pairs-discordant-for-long-term-hormone-replacement-therapy
#12
Elina Sillanpää, Paula Niskala, Eija K Laakkonen, Elodie Ponsot, Markku Alén, Jaakko Kaprio, Fawzi Kadi, Vuokko Kovanen, Sarianna Sipilä
Estrogen-based hormone replacement therapy (HRT) may be associated with deceleration of cellular aging. We investigated whether long-term HRT has effects on leukocyte (LTL) or mean and minimum skeletal muscle telomere length (SMTL) in a design that controls for genotype and childhood environment. Associations between telomeres, body composition, and physical performance were also examined. Eleven monozygotic twin pairs (age 57.6 ± 1.8 years) discordant for HRT were studied. Mean duration of HRT use was 7.3 ± 3...
February 14, 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28191278/impact-of-yoga-and-meditation-on-cellular-aging-in-apparently-healthy-individuals-a-prospective-open-label-single-arm-exploratory-study
#13
Madhuri Tolahunase, Rajesh Sagar, Rima Dada
This study was designed to explore the impact of Yoga and Meditation based lifestyle intervention (YMLI) on cellular aging in apparently healthy individuals. During this 12-week prospective, open-label, single arm exploratory study, 96 apparently healthy individuals were enrolled to receive YMLI. The primary endpoints were assessment of the change in levels of cardinal biomarkers of cellular aging in blood from baseline to week 12, which included DNA damage marker 8-hydroxy-2'-deoxyguanosine (8-OH2dG), oxidative stress markers reactive oxygen species (ROS), and total antioxidant capacity (TAC), and telomere attrition markers telomere length and telomerase activity...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28187293/assessing-the-contributions-of-childhood-maltreatment-subtypes-and-depression-case-control-status-on-telomere-length-reveals-a-specific-role-of-physical-neglect
#14
John Vincent, Iiris Hovatta, Souci Frissa, Laura Goodwin, Matthew Hotopf, Stephani L Hatch, Gerome Breen, Timothy R Powell
BACKGROUND: Studies have provided evidence that both childhood maltreatment and depressive disorders are associated with shortened telomere lengths. However, as childhood maltreatment is a risk factor for depression, it remains unclear whether this may be driving shortened telomere lengths observed amongst depressed patients. Furthermore, it's unclear if the effects of maltreatment on telomere length shortening are more pervasive amongst depressed patients relative to controls, and consequently whether biological ageing may contribute to depression's pathophysiology...
February 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28186493/telomeres-shorten-and-then-lengthen-before-fledging-in-magellanic-penguins-spheniscus-magellanicus
#15
Jack A Cerchiara, Rosa Ana Risques, Donna Prunkard, Jeffrey R Smith, Olivia J Kane, P Dee Boersma
For all species, finite metabolic resources must be allocated toward three competing systems: maintenance, reproduction, and growth. Telomeres, the nucleoprotein tips of chromosomes, which shorten with age in most species, are correlated with increased survival. Chick growth is energetically costly and is associated with telomere shortening in most species. To assess the change in telomeres in penguin chicks, we quantified change in telomere length of wild known-age Magellanic penguin (Spheniscus magellanicus) chicks every 15 days during the species' growth period, from hatching to 60 days-of-age...
February 8, 2017: Aging
https://www.readbyqxmd.com/read/28186106/impact-of-dehydroepiandrosterone-sulfate-on-newborn-leukocyte-telomere-length
#16
Han Liu, Guangdi Zhou, Qian Chen, Fengxiu Ouyang, Julian Little, Jun Zhang, Dan Chen
The newborn setting of leukocyte telomere length (LTL) likely has important implications for telomere dynamics over the lifespan. However, its determinants are poorly understood. Hormones play an important role during pregnancy and delivery. We hypothesized that exposure to hormones may impact the fetal telomere biology system. To test this hypothesis, cortisol, estradiol, dehydroepiandrosterone sulfate (DHEAS) and reactive oxygen species (ROS) were measured in cord blood of 821 newborns from a prospective study...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28185343/birth-and-death-evidence-for-the-same-biologic-clock
#17
Mark Phillippe, Shiela M Phillippe
In mammals, there exists a strong correlation between the average life span (in years) and the length of gestation (in days), suggesting that the same biologic clock mechanisms control both of these physiologic events. Life span is determined by a complex sequence of events leading to organismal senescence, and ultimately death. Although multiple biochemical and cellular phenomena are believed to be involved, progressive telomere shortening due to oxidative stress and loss during DNA replication is believed to be an important determinant contributing to aging, senescence, and adult death...
February 10, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28179486/serum-25-hydroxyvitamin-d-has-a-modest-positive-association-with-leukocyte-telomere-length-in-middle-aged-us-adults
#18
Julia Beilfuss, Carlos A Camargo, Elena Kamycheva
Background: Vitamin D deficiency has been linked to all-cause mortality and cancer. However, the biological plausibility of these associations is not well established. Leukocyte telomere length (LTL) shortening is associated with aging and is a hallmark of genomic instability and carcinogenesis.Objective: We aimed to investigate the association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and LTL in the general US population.Methods: We analyzed data from the US NHANES 2001-2002. The study population comprised 1542 younger adults (aged 20-39 y), 1336 middle-aged adults (aged 40-59 y), and 1382 older adults (aged ≥60 y)...
February 8, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28179311/telomere-length-and-risk-of-hepatocellular-carcinoma-a-nested-case-control-study-in-taiwan-cancer-screening-program-cohort
#19
Hui Zeng, Hui-Chen Wu, Qiao Wang, Hwai-I Yang, Chien-Jen Chen, Regina M Santella, Jing Shen
BACKGROUND: Telomere length (TL) measured in peripheral blood leucocytes (PBL) might be a useful biomarker to identify elevated cancer risk. PATIENTS AND METHODS: A case-control study which included 268 newly-diagnosed HCC cases and 536 matched controls, was conducted. Absolute TL in PBL was analyzed by quantitative real-time PCR. RESULTS: The overall median length of TL was not statistically shorter in HCC cases compared to healthy controls...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28178350/effects-of-size-at-birth-childhood-growth-patterns-and-growth-hormone-treatment-on-leukocyte-telomere-length
#20
Carolina C J Smeets, Veryan Codd, Matthew Denniff, Nilesh J Samani, Anita C S Hokken-Koelega
BACKGROUND: Small size at birth and rapid growth in early life are associated with increased risk of cardiovascular disease in later life. Short children born small for gestational age (SGA) are treated with growth hormone (GH), inducing catch-up in length. Leukocyte telomere length (LTL) is a marker of biological age and shorter LTL is associated with increased risk of cardiovascular disease. OBJECTIVES: To investigate whether LTL is influenced by birth size, childhood growth and long-term GH treatment...
2017: PloS One
keyword
keyword
73405
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"