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telomere length

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https://www.readbyqxmd.com/read/28100466/associations-of-accelerometer-measured-and-self-reported-sedentary-time-with-leukocyte-telomere-length-in-older-women
#1
Aladdin H Shadyab, Caroline A Macera, Richard A Shaffer, Sonia Jain, Linda C Gallo, Michael J LaMonte, Alexander P Reiner, Charles Kooperberg, Cara L Carty, Chongzhi Di, Todd M Manini, Lifang Hou, Andrea Z LaCroix
Few studies have assessed the association of sedentary time with leukocyte telomere length (LTL). In a cross-sectional study conducted in 2012-2013, we examined associations of accelerometer-measured and self-reported sedentary time with LTL in a sample of 1,481 older white and African-American women from the Women's Health Initiative and determined whether associations varied by level of moderate- to vigorous-intensity physical activity (MVPA). The association between sedentary time and LTL was evaluated using multiple linear regression models...
January 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28099165/the-spectral-properties-of-dna-and-rna-macromolecules-at-low-temperatures-fundamental-and-applied-aspects
#2
Valeriy M Yashchuk, Vladislav Yu Kudrya
This paper summarizes the results of studies of the spectral properties-optical absorption, fluorescence and phosphorescence-of DNA and RNA macromolecules and synthetic poly-, oligo- and mono-nucleotides, which have been carried out in our laboratory. The system of first excited singlet and triplet energy levels for DNA and RNA is evaluated using low-temperature (4.2 K-77 K) luminescent measurements. The traps of the singlet and triplet electronic excitations in these compounds are identified. An important self-protection mechanism against photo-damage of DNA and RNA by UV photons or penetrative radiation based on the capture of triplet electronic-energy excitations by the most photostable centers-in DNA, the complex formed by neighboring adenosine (A) and thymidine (T) links; in RNA, the adenosine links-is described...
January 18, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28095086/retinal-findings-and-a-novel-tinf2-mutation-in-revesz-syndrome-clinical-and-molecular-correlations-with-pediatric-retinal-vasculopathies
#3
Mrinali P Gupta, Katherine E Talcott, David Y Kim, Suneet Agarwal, Shizuo Mukai
BACKGROUND: Revesz syndrome is a telomere disorder in the dyskeratosis congenita (DKC) spectrum characterized by exudative retinopathy, bone marrow failure, neuroradiographic abnormalities, and integumentary findings. MATERIALS/METHODS: We report the ophthalmologic findings, documented by examinations under anesthesia with clinical photography and fluorescein angiography, as well as the systemic manifestations and genetic and molecular testing, in identical twins with Revesz syndrome, and compare and contrast these features to those of other pediatric retinal vasculopathies...
January 17, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28081238/genomic-organization-of-repetitive-dna-in-woodpeckers-aves-piciformes-implications-for-karyotype-and-zw-sex-chromosome-differentiation
#4
Thays Duarte de Oliveira, Rafael Kretschmer, Natasha Avila Bertocchi, Tiago Marafiga Degrandi, Edivaldo Herculano Corrêa de Oliveira, Marcelo de Bello Cioffi, Analía Del Valle Garnero, Ricardo José Gunski
Birds are characterized by a low proportion of repetitive DNA in their genome when compared to other vertebrates. Among birds, species belonging to Piciformes order, such as woodpeckers, show a relatively higher amount of these sequences. The aim of this study was to analyze the distribution of different classes of repetitive DNA-including microsatellites, telomere sequences and 18S rDNA-in the karyotype of three Picidae species (Aves, Piciformes)-Colaptes melanochloros (2n = 84), Colaptes campestris (2n = 84) and Melanerpes candidus (2n = 64)-by means of fluorescence in situ hybridization...
2017: PloS One
https://www.readbyqxmd.com/read/28076340/telomere-length-assessment-for-prediction-of-organ-transplantation-outcome-future-or-failure-a-review-of-the-literature
#5
Karolina Kłoda, Leszek Domański, Artur Mierzecki
Telomeres are located at each end of eukaryotic chromosomes. Their functional role is genomic stability maintenance. The protective role of telomeres depends on various factors, including number of nucleotides repeats, telomere-binding proteins, and telomerase activity. Organ transplantation is the preferred replacement therapy in the case of chronic kidney disease and the only possibility of sustaining recipients' life in the case of advanced liver failure. While the prevalence of acute rejection is constantly decreasing, prevention of transplanted organ long-term function loss is still challenging...
January 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28074901/live-visualization-of-genomic-loci-with-bifc-tale
#6
Huan Hu, Hongmin Zhang, Sheng Wang, Miao Ding, Hui An, Yingping Hou, Xiaojing Yang, Wensheng Wei, Yujie Sun, Chao Tang
Tracking the dynamics of genomic loci is important for understanding the mechanisms of fundamental intracellular processes. However, fluorescent labeling and imaging of such loci in live cells have been challenging. One of the major reasons is the low signal-to-background ratio (SBR) of images mainly caused by the background fluorescence from diffuse full-length fluorescent proteins (FPs) in the living nucleus, hampering the application of live cell genomic labeling methods. Here, combining bimolecular fluorescence complementation (BiFC) and transcription activator-like effector (TALE) technologies, we developed a novel method for labeling genomic loci (BiFC-TALE), which largely reduces the background fluorescence level...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28070333/corticosterone-inflammation-immune-status-and-telomere-length-in-frigatebird-nestlings-facing-a-severe-herpesvirus-infection
#7
Manrico Sebastiano, Marcel Eens, Frederic Angelier, Kévin Pineau, Olivier Chastel, David Costantini
Herpesvirus outbreaks are common in natural animal populations, but little is known about factors that favour the infection and its consequences for the organism. In this study, we examined the pathophysiological consequences of a disease probably attributable to herpesvirus infection for several markers of immune function, corticosterone, telomere length and inflammation. In addition, we assessed whether any markers used in this study might be associated with the occurrence of visible clinical signs of the disease and its impact on short-term survival perspectives...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/28067869/clinical-and-biological-markers-of-premature-aging-after-autologous-sct-in-childhood-cancer
#8
A Vatanen, M Hou, T Huang, O Söder, T Jahnukainen, M Kurimo, T H Ojala, T Sarkola, M Turanlahti, U M Saarinen-Pihkala, K Jahnukainen
The aim of this study was to analyze the prevalence of frailty and physical health limitations among long-term survivors of high-risk neuroblastoma (HR NBL) and to investigate whether frail health is associated with variables of cardiovascular function, markers of inflammation and telomere length. A national study cohort of 19 (median age 22, range 16-30 years) long-term (>10 years) HR NBL survivors was studied and the findings were compared with 20 age- and sex-matched controls. Frailty was defined as ⩾3 of the following conditions: low muscle mass, low energy expenditure, slow running and weakness...
January 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28064387/the-role-of-histone-modifications-and-telomere-alterations-in-the-pathogenesis-of-diffuse-gliomas-in-adults-and-children
#9
REVIEW
Julieann Lee, D A Solomon, Tarik Tihan
Genetic profiling is an increasingly useful tool for sub-classification of gliomas in adults and children. Specific gene mutations, structural rearrangements, DNA methylation patterns, and gene expression profiles are now recognized to define molecular subgroups of gliomas that arise in distinct anatomic locations and patient age groups, and also provide a better prediction of clinical outcomes for glioma patients compared to histologic assessment alone. Understanding the role of these distinctive genetic alterations in gliomagenesis is also important for the development of potential targeted therapeutic interventions...
January 7, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28058238/sedentary-behavior-physical-activity-and-cardiorespiratory-fitness-on-leukocyte-telomere-length
#10
Meghan K Edwards, Paul D Loprinzi
Background: Emerging work is starting to investigate the cumulative effects of moderate-to-vigorous physical activity (MVPA), sedentary behavior and cardiorespiratory fitness on health. The objective of this study was to examine the cumulative and independent associations of MVPA, sedentary behavior and cardiorespiratory fitness on leukocyte telomere length (LTL). Methods: Data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES) were used (N = 1868 adults 20+ years); analyzed in 2016...
2017: Health Promotion Perspectives
https://www.readbyqxmd.com/read/28057933/polymorphisms-in-telomere-length-associated-terc-and-tert-predispose-for-ischemic-stroke-in-a-chinese-han-population
#11
Shuo Zhang, Guofa Ji, Yiqian Liang, Rui Zhang, Puyu Shi, Dangshe Guo, Chunqi Li, Jing Feng, Feng Liu, Rong Peng, Mingwei Chen
The role of telomere in genomic stability is an established fact. Variation in leukocyte telomere length (LTL) has been considered a crucial factor that associated with age-associated diseases. To elucidate the association between LTL variation and ischemic stroke (IS) risk, we selected ten single nucleotide polymorphisms (SNPs) in three genes (TERC, TERT and RTEL1) that previously reported link to LTL, and genotyped SNPs of these genes in a case-control study. The association between polymorphisms and IS risk were tested by Chi squared test and haplotype analysis...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28056862/association-between-telomere-length-and-the-risk-of-colorectal-cancer-a-meta-analysis-of-observational-studies
#12
Cho Naing, Kyan Aung, Pei Kuan Lai, Joon Wah Mak
BACKGROUND: Human chromosomes are capped and stabilized by telomeres. Telomere length regulates a 'cellular mitotic clock' that defines the number of cell divisions and hence, cellular life span. This study aimed to synthesize the evidence on the association between peripheral blood leucocytes (PBL) telomere length and the risk of colorectal cancer (CRC). METHODS: We searched relevant studies in electronic databases. When two or more observational studies reported the same outcome measures, we performed pooled analysis...
January 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28055115/measurement-of-t-cell-telomere-length-using-amplified-signal-fish-staining-and-flow-cytometry
#13
Andrea L Henning, Danielle E Levitt, Jakob L Vingren, Brian K McFarlin
Exposure to pathogen-associated molecular patterns (PAMPS), damage-associated molecular patterns (DAMPS), and physiologically challenging stimuli either positively or negatively affect leukocyte maturity. Cellular maturity has implications for the effectiveness of host response to bacterial or viral infection and/or tissue injury. Thus, the ability to accurately assess cellular maturity and health is important to fully understand immune status and function. The most common technique for measuring cellular maturity is to measure telomere length; however, existing techniques are not optimized for single-cell measurements using flow cytometry...
January 5, 2017: Current Protocols in Cytometry
https://www.readbyqxmd.com/read/28055113/assessment-of-telomere-length-phenotype-and-dna-content
#14
Theodoros Kelesidis, Ingrid Schmid
Telomere sequences at the end of chromosomes control somatic cell division; therefore, telomere length in a given cell population provides information about its replication potential. This unit describes a method for flow cytometric measurement of telomere length in subpopulations using fluorescence in situ hybridization of fluorescently-labeled probes (Flow-FISH) without prior cell separation. After cells are stained for surface immunofluorescence, antigen-antibody complexes are covalently cross-linked onto cell membranes before FISH with a telomere-specific probe...
January 5, 2017: Current Protocols in Cytometry
https://www.readbyqxmd.com/read/28052383/liver-damage-and-senescence-increases-in-patients-developing-hepatocellular-carcinoma
#15
Silvia Rey, Cristina Quintavalle, Katharina Burmeister, Diego Calabrese, Manuel Schlageter, Luca Quagliata, Gieri Cathomas, Joachim Diebold, Alfredo Molinolo, Markus H Heim, Luigi M Terracciano, Matthias S Matter
BACKGROUND & AIMS: Most patients with a hepatocellular carcinoma (HCC) have an underlying chronic liver inflammation, which causes a continuous damage leading to liver cirrhosis and eventually HCC. However, only a minority of cirrhotic patients develop HCC. To asses a possible differential impact of liver inflammation in patients developing HCC versus patients remaining tumor-free we designed a longitudinal study and analyzed liver tissue of the same patient (n = 33) at two points in time: once when no HCC was present and once, several years later, when a HCC was present...
January 3, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28052260/telomere-recognition-and-assembly-mechanism-of-mammalian-shelterin
#16
Fabian Erdel, Katja Kratz, Smaranda Willcox, Jack D Griffith, Eric C Greene, Titia de Lange
Shelterin is a six-subunit protein complex that plays crucial roles in telomere length regulation, protection, and maintenance. Although several shelterin subunits have been studied in vitro, the biochemical properties of the fully assembled shelterin complex are not well defined. Here, we characterize shelterin using ensemble biochemical methods, electron microscopy, and single-molecule imaging to determine how shelterin recognizes and assembles onto telomeric repeats. We show that shelterin complexes can exist in solution and primarily locate telomeric DNA through a three-dimensional diffusive search...
January 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28050886/evaluation-of-cortisol-and-telomere-length-measurements-in-ethnically-diverse-women-with-breast-cancer-using-culturally-sensitive-methods
#17
Julio Ramirez, May Elmofty, Esperanza Castillo, Mindy DeRouen, Salma Shariff-Marco, Laura Allen, Scarlett Lin Gomez, Anna María Nápoles, Leticia Márquez-Magaña
The under-representation of ethnic minority participants, who are more likely to be socially disadvantaged in biomedical research, limits generalizability of results and reductions in health disparities. To facilitate investigations of how social disadvantage "gets under the skin," this pilot study evaluated low-intensity methods for collecting hair and saliva samples from multiethnic breast cancer survivors (N = 70) and analysis of biomarkers of chronic stress (cortisol levels) and biological age (telomere length)...
January 3, 2017: Journal of Community Genetics
https://www.readbyqxmd.com/read/28039478/genetic-polymorphisms-in-the-telomere-length-related-gene-acyp2-are-associated-with-the-risk-of-colorectal-cancer-in-a-chinese-han-population
#18
Fang Liu, Zhongguo Zhang, Yong Zhang, Yue Chen, Xiaoyu Yang, Jibin Li, Jiaxing Zhao
We investigated the association between single nucleotide polymorphisms (SNPs) in ACYP2, which has been associated with telomere length in several types of cancer, and the risk of CRC in a Chinese Han population. In a case-control study that included 247 cases and 300 healthy controls, 14 SNPs in ACYP2 were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression after adjusting for age and gender...
December 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/28039025/common-variants-of-human-tert-and-terc-genes-and-susceptibility-to-sporadic-alzheimers-disease
#19
D Scarabino, E Broggio, G Gambina, F Pelliccia, R M Corbo
Studies investigating telomere length in association with cognitive decline, dementia, and sporadic Alzheimer's disease (AD) have frequently found shorter telomeres to be associated with the development of AD and telomerase expression with pathological processes in AD. Human telomerase is constituted by two components: the telomerase reverse transcriptase (TERT) and the telomerase RNA component (TERC). Genetic variation at the two loci has been investigated in relation to telomere length, longevity, and common diseases of advanced age, but not in relation to AD...
December 27, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/28038425/knock-out-of-the-nadph-oxidase-nox4-has-no-impact-on-life-span-in-mice
#20
Flavia Rezende, Christoph Schürmann, Susanne Schütz, Sabine Harenkamp, Eva Herrmann, Michael Seimetz, Norbert Weißmann, Katrin Schröder
The free radical theory of aging suggests reactive oxygen species as a main reason for accumulation of damage events eventually leading to aging. Nox4, a member of the family of NADPH oxidases constitutively produces ROS and therefore has the potential to be a main driver of aging. Herein we analyzed the life span of Nox4 deficient mice and found no difference when compared to their wildtype littermates. Accordingly neither Tert expression nor telomere length was different in cells isolated from those animals...
December 22, 2016: Redox Biology
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