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telomere length

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https://www.readbyqxmd.com/read/28727527/television-watching-and-telomere-length-among-adults-in-southwest-china
#1
Hong-Mei Xue, Qian-Qian Liu, Guo Tian, Li-Ming Quan, Yong Zhao, Guo Cheng
OBJECTIVES: To explore the independent associations of sedentary behavior and physical activity with telomere length among Chinese adults. METHODS: Data on total time of sedentary behavior, screen-based sedentary behavior (including television watching and computer or phone use), moderate to vigorous physical activity, and dietary intake of 518 adults in Chengdu, Guizhou, and Xiamen in China (54.25% women) aged 20 to 70 years were obtained between 2013 and 2015 through questionnaires...
July 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28725051/mammographic-density-blood-telomere-length-and-lipid-peroxidation
#2
Natalie J Erdmann, Lea A Harrington, Lisa J Martin
Extensive mammographic density is a strong risk factor for breast cancer, but may also be an indicator of biological age. In this study we examined whether mammographic density is related to blood telomere length, a potential marker of susceptibility to age-related disease. We measured mammographic density by a computer assisted method and blood telomere length using a validated PCR method. Urinary malondialdehyde (MDA), a marker of lipid peroxidation, was measured in 24 hour urine collections. In the 342 women examined telomere length was negatively correlated with age, was lower in postmenopausal compared to premenopausal women and in smokers compared to non-smokers, and was positively correlated with urinary MDA...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724638/smoking-telomere-length-and-lung-function-decline-a-longitudinal-population-based-study
#3
Pascal Andujar, Dominique Courbon, Emilie Bizard, Elisabeth Marcos, Serge Adnot, Laurent Boyer, Pascal Demoly, Debbie Jarvis, Catherine Neukirch, Isabelle Pin, Gabriel Thabut, Jorge Boczkowski, Bénédicte Leynaert
Telomere shortening is associated with COPD and impaired lung function in cross-sectional studies, but there is no longitudinal study. We used data from 448 participants recruited as part of the French follow-up of the European Community Respiratory Health Survey. We found no relationship between telomere length at baseline and FEV1 decline after 11 years of follow-up. However, heavy smoking was associated with an accelerated FEV1 decline in individuals with short telomeres, but not in subjects with longer telomeres (p for interaction p=0...
July 19, 2017: Thorax
https://www.readbyqxmd.com/read/28721449/role-of-regulatory-t-cells-in-acute-myeloid-leukemia-patients-undergoing-relapse-preventive-immunotherapy
#4
Frida Ewald Sander, Malin Nilsson, Anna Rydström, Johan Aurelius, Rebecca E Riise, Charlotta Movitz, Elin Bernson, Roberta Kiffin, Anders Ståhlberg, Mats Brune, Robin Foà, Kristoffer Hellstrand, Fredrik B Thorén, Anna Martner
Regulatory T cells (Tregs) have been proposed to dampen functions of anti-neoplastic immune cells and thus promote cancer progression. In a phase IV trial (Re:Mission Trial, NCT01347996, http://www.clinicaltrials.gov ) 84 patients (age 18-79) with acute myeloid leukemia (AML) in first complete remission (CR) received ten consecutive 3-week cycles of immunotherapy with histamine dihydrochloride (HDC) and low-dose interleukin-2 (IL-2) to prevent relapse of leukemia in the post-consolidation phase. This study aimed at defining the features, function and dynamics of Foxp3(+)CD25(high)CD4(+) Tregs during immunotherapy and to determine the potential impact of Tregs on relapse risk and survival...
July 18, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28720163/transferrin-saturation-concentrations-associated-with-telomeric-ageing-a-population-based-study
#5
Chol Shin, Inkyung Baik
There are limited data on the association between Fe overload and leucocyte telomere length (LTL), known as a useful biomarker of the replicative ageing of cells. The aim of the study was to evaluate associations between Fe-status biomarkers and LTL. A cross-sectional study included 1174 men and women aged 50-79 years who provided blood samples for assays of Fe-status biomarkers including ferritin, transferrin saturation (TSAT), total Fe-binding capacity (TIBC) and relative LTL. They were free of hepatitis, potential infection or Fe deficiency...
July 19, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28718437/mutations-cancer-and-the-telomere-length-paradox
#6
REVIEW
Abraham Aviv, James J Anderson, Jerry W Shay
Individuals with short telomeres should be at increased risk for cancer, since short telomeres lead to genomic instability - a hallmark of cancer. However, individuals with long telomeres also display an increased risk for major cancers, thus creating a cancer-telomere length (TL) paradox. The two-stage clonal expansion model we propose is based on the thesis that a series of mutational hits (1st Hit) at the stem-cell level generates a clone with replicative advantage. A series of additional mutational hits (2nd Hit) transforms the expanding clone into cancer...
April 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28718371/changes-in-the-expression-of-genes-involved-in-cell-cycle-regulation-and-the-relative-telomere-length-in-the-process-of-canceration-induced-by-omethoate
#7
Xiaoran Duan, Yongli Yang, Sihua Wang, Xiaolei Feng, Tuanwei Wang, Pengpeng Wang, Suxiang Liu, Lei Li, Wu Yao, Liuxin Cui, Wei Wang
Organophosphorous pesticides (OPs), with high efficiency, broad-spectrum and low residue, are widely used in China. Omethoate is a broad category of organophosphorous pesticides and is more domestically utilized which has chronic toxic effect on human health caused by long-term, low-dose exposure to Ops, recently its potential genotoxicity has attracted wide attention which can cause chromosomal DNA damage. Thus, the aim of this study is screen susceptible biomarkers and explore the mechanism of canceration induced by omethoate...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28716823/father-loss-and-child-telomere-length
#8
Colter Mitchell, Sara McLanahan, Lisa Schneper, Irv Garfinkel, Jeanne Brooks-Gunn, Daniel Notterman
BACKGROUND AND OBJECTIVES: Father loss during childhood has negative health and behavioral consequences, but the biological consequences are unknown. Our goal was to examine how father loss (because of separation and/or divorce, death, or incarceration) is associated with cellular function as estimated by telomere length. METHODS: Data come from the 9-year follow-up of the Fragile Families and Child Wellbeing Study, a birth cohort study of children in 20 large American cities (N = 2420)...
July 18, 2017: Pediatrics
https://www.readbyqxmd.com/read/28715381/modified-terminal-restriction-fragment-analysis-for-quantifying-telomere-length-using-in-gel-hybridization
#9
Frank J Jenkins, Charles M Kerr, Elise Fouquerel, Dana H Bovbjerg, Patricia L Opresko
There are several different techniques for measuring telomere length, each with their own advantages and disadvantages. The traditional approach, Telomere Restriction Fragment (TRF) analysis, utilizes a DNA hybridization technique whereby genomic DNA samples are digested with restriction enzymes, leaving behind telomere DNA repeats and some sub-telomeric DNA. These are separated by agarose gel electrophoresis, transferred to a filter membrane and hybridized to oligonucleotide probes tagged with either chemiluminescence or radioactivity to visualize telomere restriction fragments...
July 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28712425/telomere-length-is-inversely-correlated-with-urinary-stress-hormone-levels-in-healthy-controls-but-not-in-un-medicated-depressed-individuals-preliminary-findings
#10
Brittany Fair, Synthia H Mellon, Elissa S Epel, Jue Lin, Dóra Révész, Josine E Verhoeven, Brenda W Penninx, Victor I Reus, Rebecca Rosser, Christina M Hough, Laura Mahan, Heather M Burke, Elizabeth H Blackburn, Owen M Wolkowitz
OBJECTIVE: Leukocyte telomere length (LTL) is a biomarker of cellular aging affected by chronic stress. The relationship of LTL to the stress hormones, cortisol and catecholamines, is unclear, as are possible differences between healthy controls (HC) and individuals with Major Depressive Disorder (MDD). This small pilot study is the first to examine the relationship between cortisol, catecholamines and LTL specifically in un-medicated MDD in comparison with HC. METHODS: Participants included 16 un-medicated MDD subjects and 15 HC for assay of LTL, 12-hour overnight urinary free cortisol and catecholamine levels...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28707432/mechanisms-of-breast-cancer-risk-in-shift-workers-association-of-telomere-shortening-with-the-duration-and-intensity-of-night-work
#11
Johanna Samulin Erdem, Heidi Ødegaard Notø, Øivind Skare, Jenny-Anne S Lie, Marte Petersen-Øverleir, Edyta Reszka, Beata Pepłońska, Shanbeh Zienolddiny
Occupational factors such as shiftwork and especially night work that involves disruption of the circadian rhythm may contribute to increased breast cancer risk. Circadian disruption may also affect telomere length (TL). While short TL generally is associated with increased cancer risk, its association with breast cancer risk is inconclusive. We suggest that working schedules might be an important factor in assessment of effects of TL on breast cancer risk. Moreover, telomere shortening might be a potential mechanism for night work-related breast cancer...
July 14, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28705731/do-glucocorticoids-mediate-the-link-between-environmental-conditions-and-telomere-dynamics-in-wild-vertebrates-a-review
#12
REVIEW
Frédéric Angelier, David Costantini, Pierre Blévin, Olivier Chastel
Following the discoveries of telomeres and of their implications in terms of health and ageing, there has been a growing interest into the study of telomere dynamics in wild vertebrates. Telomeres are repeated sequences of non-coding DNA located at the terminal ends of chromosomes and they play a major role in maintaining chromosome stability. Importantly, telomeres shorten over time and shorter telomeres seem to be related with lower survival in vertebrates. Because of this potential link with longevity, it is crucial to understand not only the ecological determinants of telomere dynamics but also the regulatory endocrine mechanisms that may mediate the effect of the environment on telomeres...
July 10, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28704801/stress-depressive-status-and-telomere-length-does-social-interaction-and-coping-strategy-play-a-mediating-role
#13
Jia Jia Liu, Ya Bin Wei, Yvonne Forsell, Catharina Lavebratt
BACKGROUND: Telomeres have been reported to be shorter in individuals exposed to psychosocial stress and in those with depression. Since negative environmental stress is a risk factor for depression, the present study tested whether stressors in childhood (CA) and recent adulthood (NLE) predicted telomere attrition directly and/or indirectly through individuals' depressive status 3-6 years before TL measurement; and then if social interaction and coping strategies in adulthood influenced the relationship between depressive status and TL...
July 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28704792/cigarette-smoking-and-telomere-length-a-systematic-review-of-84-studies-and-meta-analysis
#14
Yuliana Astuti, Ardyan Wardhana, Johnathan Watkins, Wahyu Wulaningsih
BACKGROUND: Cigarette smoking is a risk factor for ageing-related disease, but its association with biological ageing, indicated by telomere length, is unclear. METHODS: We systematically reviewed evidence evaluating association between smoking status and telomere length. Searches were performed in MEDLINE (Ovid) and EMBASE (Ovid) databases, combining variation of keywords "smoking" and "telomere". Data was extracted for study characteristics and estimates for association between smoking and telomere length...
July 10, 2017: Environmental Research
https://www.readbyqxmd.com/read/28701205/art-therapy-and-music-reminiscence-activity-in-the-prevention-of-cognitive-decline-study-protocol-for-a-randomized-controlled-trial
#15
Rathi Mahendran, Iris Rawtaer, Johnson Fam, Jonathan Wong, Alan Prem Kumar, Mihir Gandhi, Kenny Xu Jing, Lei Feng, Ee Heok Kua
BACKGROUND: Attention has shifted to the use of non-pharmacological interventions to prevent cognitive decline as a preventive strategy, as well as for those at risk and those with mild cognitive impairment. Early introduction of psycho-social interventions can address cognitive decline and significantly impact quality of life and the wellbeing of elderly individuals. This pilot study explores the feasibility of using art therapy and music reminiscence activity to improve the cognition of community living elderly with mild cognitive impairment...
July 12, 2017: Trials
https://www.readbyqxmd.com/read/28700349/association-of-tert-polymorphisms-and-risk-of-coronary-heart-disease-in-a-chinese-han-population
#16
Hongmei Han, Jianxia Zhang, Jianghong Hou, Haibo Wang, Jianpeng Zheng, Huan Wang, Zhong Zhong, Yijin Wang, Xiaoni Wang, Bei Yang, Lei Wang, Dangjun Quan, Junnong Li
Genome-wide association studies have identified that TERT gene was associated with telomere length and age-related diseases. However, little study directly focused on the association between TERT gene polymorphisms and risk of coronary heart disease (CHD). We conducted a case-control study to examine the effect of TERT polymorphisms on CHD risk among 596 CHD patients and 603 healthy controls from China. Five significant single nucleotide polymorphisms (SNP) in TERT were selected and genotyped using Sequenom Mass-ARRAY technology...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28700015/telomere-length-and-htert-in-mania-and-subsequent-remission
#17
Rugül Köse Çinar
Objective: The findings of telomere length (TL) studies in bipolar disorder (BD) are controversial. The aim of the present study was to detect TL, human telomerase reverse transcriptase (hTERT), and brain derived neurotrophic factor (BDNF) in severe mania and subsequent remission. Methods: Twenty-one medication-free male patients and 20 age and gender matched controls were recruited. The patients were followed in the inpatient clinic, and comparisons were made between the same patients in their remission state and controls...
July 6, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28699658/telomere-length-and-somatic-mutations-in-correlation-with-response-to-immunosuppressive-treatment-in-aplastic-anaemia
#18
Hee S Park, Si N Park, Kyongok Im, Sung-Min Kim, Jung-Ah Kim, Sang M Hwang, Dong S Lee
We investigated the frequencies of cytogenetic aberrations and somatic mutations of prognostic relevance in 393 patients with aplastic anaemia (AA). Clonality was determined by G-banding/fluorescence in situ hybridization (FISH) (n = 245), and targeted capture sequencing was performed for 88 haematopoiesis-related genes (n = 70). The telomere length (TL) of bone marrow nucleated cells was measured at the single cell level by FISH (n = 135). Eighteen (4·6%) patients showed disease progression, and monosomy 7 (50·0%) was the most predominant cytogenetic evolution at disease transformation...
July 12, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28699197/sperm-telomere-length-in-motile-sperm-selection-techniques-a-qfish-approach
#19
R Lafuente, E Bosch-Rue, J Ribas-Maynou, J Alvarez, C Brassesco, M J Amengual, J Benet, A Garcia-Peiró, M Brassesco
Several studies have associated telomere shortening with alterations in reproductive function. The objective of the present study was to determine telomere length (TL) in spermatozoa selected by either density-gradient centrifugation (DGC) or swim-up. The analysis of TL was performed using quantitative fluorescent in situ hybridisation (qFISH) using PNA probes in combination with a chromatin decompaction protocol in sperm cells. Results of TL were 24.64 ± 5.00 Kb and 24.95 ± 4.60 Kb before and after DGC, respectively, and 19...
July 11, 2017: Andrologia
https://www.readbyqxmd.com/read/28697059/associations-between-age-psychosocial-work-conditions-occupational-well-being-and-telomere-length-in-geriatric-care-professionals-a-mixed-methods-study
#20
Caroline Chmelar, Rudolf A Jörres, Angelika Kronseder, Andreas Müller, Dennis Nowak, Matthias Weigl
OBJECTIVE: We identified associations between age, psychosocial work characteristics, occupational well-being, and-as a measure of biological age-leukocyte telomere length in geriatric care professionals. METHODS: This is a multisource study of self-reports on psychosocial work characteristics, standardized physician's evaluations of health, and relative telomere length measures of peripheral blood leukocytes. We included 141 geriatric care professionals. Telomere length was assessed by an improved polymerase chain reaction (PCR)-based method...
July 10, 2017: Journal of Occupational and Environmental Medicine
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