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https://www.readbyqxmd.com/read/28531819/welfare-consequences-for-people-with-epilepsy-and-their-partners-a-matched-nationwide-study-in-denmark
#1
Poul Jennum, Anne Sabers, Jakob Christensen, Rikke Ibsen, Jakob Kjellberg
PURPOSE: We aimed to evaluate the excess direct and indirect costs associated with epilepsy. METHODS: From the Danish National Patient Registry (1998-2013), we identified people within all ages with an epilepsy diagnosis and matched them to control individuals. Additionally, partners of people with epilepsy were identified, who were compared with control partners. Direct costs included frequencies and costs of hospitalizations and weighted outpatient use according to diagnosis-related group, and specific outpatient costs based on data from the Danish Ministry of Health...
May 12, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28531786/malnutrition-related-deaths
#2
Maja Sparre-Sørensen, Gustav N Kristensen
BACKGROUND AND AIMS: Studies have shown that malnutrition increases the risk of morbidity, mortality, the length of hospital stay, and costs in the elderly population. Approximately one third of all patients admitted to geriatric wards in Denmark are malnourished according to the Danish Geriatric database. The aim of this study is to describe and examine the sudden increase in deaths due to malnutrition in the elderly population in Denmark from 1999 and, similarly, the sudden decline in malnutrition related deaths in 2007...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531378/cognitive-ability-in-young-adulthood-and-risk-of-dementia-in-a-cohort-of-danish-men-brothers-and-twins
#3
Merete Osler, Gunhild T Christensen, Ellen Garde, Erik L Mortensen, Kaare Christensen
INTRODUCTION: We examined the association between cognitive ability in young adulthood and dementia in Danish men, brothers, and male twins. METHODS: In total, 666,986 men born between 1939 and 1959 were identified for dementia diagnosis in national registries from 1969 to 2016. The association between cognitive ability from draft board examination and dementia was examined using Cox regression. RESULTS: During a 44-year follow-up, 6416 (0...
May 19, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28503971/mental-vulnerability-helicobacter-pylori-and-incidence-of-hospital-diagnosed-peptic-ulcer-over-28-years-in-a-population-based-cohort
#4
Susan Levenstein, Rikke Kart Jacobsen, Steffen Rosenstock, Torben Jørgensen
OBJECTIVE: To examine whether mental vulnerability, an enduring personality characteristic, predicts incident hospital-diagnosed ulcer over three decades. MATERIALS AND METHODS: A population-based cohort study enrolled 3365 subjects with no ulcer history, ages 30-60, in 1982-3. Mental vulnerability, Helicobacter pylori IgG antibodies, socioeconomic status, and sleep duration were determined at baseline; non-steroidal antiinflammatory drug use, smoking, leisure time physical activity, and alcohol consumption both at baseline and in 1993-4...
May 14, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28503076/positive-predictive-value-of-peptic-ulcer-diagnosis-codes-in-the-danish-national-patient-registry
#5
Søren Viborg, Kirstine Kobberøe Søgaard, Peter Jepsen
BACKGROUND: Diagnoses of peptic ulcer are registered in the Danish National Patient Registry (DNPR) for administrative as well as research purposes, but it is unknown whether the coding validity depends on the location of the ulcer. OBJECTIVE: To validate the International Classification of Diseases, 10(th) revision diagnosis codes of peptic ulcer in the DNPR by estimating positive predictive values (PPVs) for gastric and duodenal ulcer diagnoses. METHODS: We identified all patients registered with a hospital discharge diagnosis of peptic ulcer from Aarhus University Hospital, Denmark, in 1995-2006...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28501739/risk-of-postpartum-episodes-in-women-with-bipolar-disorder-after-lamotrigine-or-lithium-use-during-pregnancy-a-population-based-cohort-study
#6
Richard Wesseloo, Xiaoqin Liu, Crystal T Clark, Steven A Kushner, Trine Munk-Olsen, Veerle Bergink
BACKGROUND: Women with bipolar disorder are at high risk for relapse/recurrence postpartum. Among all mood stabilizers, lithium has the largest evidence base for efficacy in the peripartum period, but lamotrigine is increasingly prescribed for bipolar spectrum disorders during pregnancy. The aim of this study was to investigate whether lamotrigine use during pregnancy is as effective as lithium in the prevention of severe episodes postpartum. METHODS: Danish national registries were used to identify pregnancies of women with a diagnosis of bipolar spectrum disorders at the time of conception who used lamotrigine or lithium during pregnancy...
May 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28498890/semen-quality-is-a-predictor-of-subsequent-morbidity-a-danish-cohort-study-of-4-712-men-with-long-term-follow-up
#7
Tabassam Latif, Tina Kold Jensen, Jesper Mehlsen, Stine Agergaard Holmboe, Louise Brinth, Kirsten Pors, Sven Olaf Skouby, Niels Jørgensen, Rune Lindahl-Jacobsen
Semen quality is suggested to be a biological marker of long-term morbidity and mortality; however, few studies have been conducted on this subject. We identified 5,785 men seen for infertility in Frederiksberg Hospital, Denmark from 1977-2010, and 4,712 men were followed in the Danish National Patient Registry until first hospitalization, death or end of the study. We classified patients according to all hospitalizations and the presence of cardiovascular disease, diabetes, testicular and prostate cancer. We found a clear association between sperm concentration below 15 mill/mL and all-cause hospitalizations, 50% (95% CI: 1...
May 11, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28487451/infant-feeding-and-risk-of-type-1-diabetes-in-two-large-scandinavian-birth-cohorts
#8
Nicolai A Lund-Blix, Stine Dydensborg Sander, Ketil Størdal, Anne-Marie Nybo Andersen, Kjersti S Rønningen, Geir Joner, Torild Skrivarhaug, Pål R Njølstad, Steffen Husby, Lars C Stene
OBJECTIVE: Our aim was to study the relation between the duration of full and any breastfeeding and risk of type 1 diabetes. RESEARCH DESIGN AND METHODS: We included two population-based cohorts of children followed from birth (1996-2009) to 2014 (Denmark) or 2015 (Norway). We analyzed data from a total of 155,392 children participating in the Norwegian Mother and Child Cohort Study and the Danish National Birth Cohort. Parents reported infant dietary practices when their child was 6 and 18 months old...
May 9, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28485258/chromosomal-aberrations-in-monozygotic-and-dizygotic-twins-versus-singletons-in-denmark-during-1968-2009
#9
Lone Kroeldrup, Lisbeth A Larsen, Christina Fagerberg, Jens M Hertz, Kaare Christensen
BACKGROUND: Hall (Embryologic development and monozygotic twinning. Acta Geneticae Medicae et Gemellologiae, Vol. 45, 1996, pp. 53-57) hypothesized that chromosomal aberrations can lead to monozygotic (MZ) twinning. However, twinning and chromosomal aberrations increase prenatal mortality and could reduce the prevalence of chromosomal aberrations in live-born twins. We compared prevalence proportion ratios (PPR) of chromosomal aberrations and trisomy 21 (T21) in live-born twins versus singletons born in Denmark during 1968-2009...
May 9, 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28485010/the-addition-of-etoposide-to-chop-is-associated-with-improved-outcome-in-alk-adult-anaplastic-large-cell-lymphoma-a-nordic-lymphoma-group-study
#10
Henrik Cederleuf, Martin Bjerregård Pedersen, Mats Jerkeman, Thomas Relander, Francesco d'Amore, Fredrik Ellin
Anaplastic large cell lymphomas (ALCLs) are rare CD30+ peripheral T-cell lymphomas (PTCLs) classified according to the expression of the anaplastic lymphoma kinase (ALK+) protein or not (ALK-). We have analysed the outcome and risk factors for survival in a population-based bi-national cohort of patients with systemic ALK+ ALCL. A total of 122 adult (≥18 years) patients diagnosed with ALK+ ALCL between 2000 and 2010 were identified from the Danish and Swedish lymphoma registries, representing 0·4% of all lymphomas...
May 8, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28482059/predictors-of-the-effectiveness-of-accreditation-on-hospital-performance-a-nationwide-stepped-wedge-study
#11
Søren Bie Bogh, Anne Mette Falstie-Jensen, Erik Hollnagel, René Holst, Jeffrey Braithwaite, Ditte Caroline Raben, Søren Paaske Johnsen
HASH(0x449b960) Objective: To identify predictors of the effectiveness of hospital accreditation on process performance measures. Design: A multi-level, longitudinal, stepped-wedge, nationwide study. Participants: All patients admitted for acute stroke, heart failure, ulcers, diabetes, breast cancer and lung cancer at Danish hospitals. Intervention: The Danish Healthcare Quality Programme that was designed to create a framework for continuous quality improvement...
May 8, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28481854/paradoxical-impact-of-ileal-pouch-anal-anastomosis-on-male-and-female-fertility-in-patients-with-ulcerative-colitis
#12
Frederik R Pachler, Søren B Brandsborg, Søren Laurberg
BACKGROUND: Birth rates in males with ulcerative colitis and ileal pouch-anal anastomosis have not been studied. OBJECTIVE: This study aimed to estimate birth rates in males and females with ulcerative colitis and study the impact of ileal pouch-anal anastomosis. DESIGN: This was a retrospective registry-based cohort study that was performed over a 30-year period. SETTINGS: Records for parenting a child from the same period were cross-linked with patient records, and birth rates were calculated using 15 through 49 years as age limits...
June 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28481052/long-term-opioid-therapy-in-denmark-a-disappointing-journey
#13
H Birke, O Ekholm, P Sjøgren, G P Kurita, J Højsted
BACKGROUND: Longitudinal population-based studies of long-term opioid therapy (L-TOT) in chronic non-cancer pain (CNCP) patients are sparse. Our study investigated incidence and predictors for initiating L-TOT and changes in self-rated health, pain interference and physical activities in long-term opioid users. METHODS: Data were obtained from the national representative Danish Health and Morbidity Surveys and The Danish National Prescription Registry. Respondents with no dispensed opioids the year before the survey were followed from 2000 and from 2005 until the end of 2012 (n = 12,145)...
May 8, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28472455/the-long-term-prognosis-for-live-birth-in-couples-initiating-fertility-treatments
#14
S S Malchau, A A Henningsen, A Loft, S Rasmussen, J Forman, A Nyboe Andersen, A Pinborg
STUDY QUESTION: What are the long-term chances of having a child for couples starting fertility treatments and how many conceive with ART, IUI and without treatment? SUMMARY ANSWER: Total 5-year live birthrates were strongly influenced by female age and ranged from 80% in women under 35-26% in women ≥40 years, overall, 14% of couples conceived naturally and one-third of couples starting treatments with intrauterine insemination delivered from that treatment. WHAT IS KNOWN ALREADY: Few studies report success rates in fertility treatments across a couple's complete fertility treatment history, across clinics, evaluating live births after insemination, ART and natural conceptions...
May 4, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28442232/a-genetic-risk-score-predicts-cardiovascular-events-in-patients-with-stable-coronary-artery-disease
#15
Morten Krogh Christiansen, Mette Nyegaard, Sanne Bøjet Larsen, Erik Lerkevang Grove, Morten Würtz, Søs Neergaard-Petersen, Anne-Mette Hvas, Henrik Kjærulf Jensen, Steen Dalby Kristensen
BACKGROUND: Genetic risk scores (GRSs) may predict cardiovascular risk in community-based populations. However, studies investigating the association with recurrent cardiovascular events in patients with established coronary artery disease (CAD) are conflicting. METHODS: We genotyped 879 patients with high-risk stable CAD and created a GRS based on 45 single nucleotide polymorphisms previously reported to be associated with CAD in genome-wide association studies...
April 19, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28432995/eye-disorder-differentiates-seasonality-outcomes-in-persons-with-severe-visual-impairment
#16
Heller Madsen, Henrik Dam, Ida Hageman
BACKGROUND: Light plays a crucial role in both the pathogenesis and treatment of seasonal affective disorder (SAD). Consequently decreased retinal sensitivity to light has been suggested to be a risk factor for SAD. In a population of persons with severe visual impairment we recently found a highly increased prevalence of SAD. We now aimed to identify eye disorders or anatomical locations with specific association to seasonality. METHODS: In 912 cases (33%) from our prior seasonal pattern assessment questionnaire (SPAQ) screening study, we retrieved eye diagnoses from the Danish National Patient Registry and analyzed for specific eye disorders or anatomical locations that significantly differentiated SPAQ outcomes (global seasonality score, (GSS) and SPAQ-SAD prevalence)...
April 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28429106/occupational-exposure-to-extremely-low-frequency-magnetic-fields-and-risk-for-central-nervous-system-disease-an-update-of-a-danish-cohort-study-among-utility-workers
#17
Camilla Pedersen, Aslak Harbo Poulsen, Naja Hulvej Rod, Patrizia Frei, Johnni Hansen, Kathrine Grell, Ole Raaschou-Nielsen, Joachim Schüz, Christoffer Johansen
PURPOSE: Evidence of whether exposure to extremely low-frequency magnetic fields (ELF-MF) is related to central nervous system diseases is inconsistent. This study updates a previous study of the incidence of such diseases in a large cohort of Danish utility workers by almost doubling the period of follow-up. METHODS: We investigated the risks for dementia, motor neurone disease, Parkinson disease, multiple sclerosis and epilepsy among 32,006 men employed at the 99 utility companies that supplied Denmark with electricity during the period 1900-1993...
April 20, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28422885/cancer-of-unknown-primary-registered-procedures-compared-with-national-integrated-cancer-pathway-for-illuminating-external-validity
#18
Anne-Kirstine Dyrvig, Knud Bonnet Yderstræde, Oke Gerke, Peter Bjødstrup Jensen, Søren Hess, Poul Flemming Høilund-Carlsen, Anders Green
Cancer of unknown primary (CUP) ranges within top 10 cancers in both incidence and mortality. As primary identification is crucial to choosing treatment, guidelines on CUP emphasize the diagnostic strategy. Whether guidelines are complied with, or if they are indeed helpful, is however unclear. We compared procedures performed in suspected CUP patients with recommendations of national guidelines to assess external validity of guidelines.The Danish National Patient Registry (NPR) comprising population data was utilized to identify the suspected CUP patients during 2009 to 2010 and explore exposure to procedures and patient survival...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28409235/anal-incontinence-after-two-vaginal-deliveries-without-obstetric-anal-sphincter-rupture
#19
Lisa K G Persson, Abelone Sakse, Jens Langhoff-Roos, Hanna Jangö
PURPOSE: To evaluate prevalence and risk factors for long-term anal incontinence in women with two prior vaginal deliveries without obstetric anal sphincter injury (OASIS) and to assess the impact of anal incontinence-related symptoms on quality of life. METHODS: This is a nation-wide cross-sectional survey study. One thousand women who had a first vaginal delivery and a subsequent delivery, both without OASIS, between 1997 and 2008 in Denmark were identified in the Danish Medical Birth Registry...
April 13, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28401355/correlation-between-early-surgical-complications-and-readmission-rate-after-ventral-hernia-repair
#20
D Kokotovic, H Sjølander, I Gögenur, F Helgstrand
PURPOSE: Postoperative surgical complications arising from ventral hernia repair have been assessed by a variety of outcome measures. The objective of this study was to correlate the Clavien Dindo Classification (CDC) graded complications with the 30-day readmission rate as early outcome measures in ventral hernia repair. Secondarily, we wanted to investigate whether the risk factors for Clavien Dindo class ≥1 and 30-day readmission were comparable. METHODS: Single-centre retrospective study including all patients (≥18 years) who underwent ventral hernia repair between January 1, 2009 and September 1, 2014 at Zealand University Hospital...
April 11, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
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