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https://www.readbyqxmd.com/read/29141610/social-relations-and-healthcare-utilisation-among-middle-aged-and-older-people-study-protocol-for-an-implementation-and-register-based-study-in-denmark
#1
Anne Sophie Bech Mikkelsen, Rikke Lund, Maria Kristiansen
BACKGROUND: While previous research establishes an association between social relations, health and use of healthcare services among older people, how to implement this knowledge in real-life settings has received much less attention. This study will explore the relationship between social relations, health and use of healthcare services in a Danish mid-life population sample. In addition, the study will explore individual and contextual factors affecting the implementation of a group-based life story intervention aimed at establishing and strengthening social relations among older people at nursing homes in Denmark...
November 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29135986/splenomegaly-diagnostic-validity-work-up-and-underlying-causes
#2
Emelie Curovic Rotbain, Dennis Lund Hansen, Ove Schaffalitzky de Muckadell, Flemming Wibrand, Allan Meldgaard Lund, Henrik Frederiksen
PURPOSE: Our aim was to assess the validity of the ICD-10 code for splenomegaly in the Danish National Registry of Patients (DNRP), as well as to investigate which underlying diseases explained the observed splenomegaly. BACKGROUND: Splenomegaly is a common finding in patients referred to an internal medical department and can be caused by a large spectrum of diseases, including haematological diseases and liver cirrhosis. However, some patients remain without a causal diagnosis, despite extensive medical work-up...
2017: PloS One
https://www.readbyqxmd.com/read/29134504/ketorolac-and-other-nsaids-increase-the-risk-of-anastomotic-leakage-after-surgery-for-gej-cancers-a-cohort-study-of-557-patients
#3
Kaare Terp Fjederholt, Cecilie Okholm, Lars Bo Svendsen, Michael Patrick Achiam, Jakob Kirkegård, Frank Viborg Mortensen
OBJECTIVE: The objective of this study is to investigate the impact of ketorolac and other nonsteroidal anti-inflammatory drugs on anastomotic leakage after surgery for gastro-esophageal-junction cancer. Within the last two decades, the incidence of gastro-esophageal-junction cancer has increased in the western world and surgery is the curative treatment modality of choice. Anastomotic leakage is a feared complication of gastro-esophageal surgery, as it increases recurrence, morbidity, and mortality...
November 13, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29120845/markers-of-dna-rna-damage-from-oxidation-as-predictors-of-a-registry-based-diagnosis-of-psychiatric-illness-in-type-2-diabetic-patients
#4
Anders Jorgensen, Volkert Siersma, Annette S Davidsen, Allan Weimann, Trine Henriksen, Henrik E Poulsen, Niels de Fine Olivarius
Oxidative stress is a potential biological mediator of the higher rates of psychiatric illness (PI) observed after the onset of type 2 diabetes (T2DM). We investigated validated urinary markers of systemic DNA/RNA damage from oxidation (8-oxodG/8-oxoGuo respectively) as predictors of incident PI in a cohort of 1381 newly diagnosed T2DM patients, who were followed prospectively for a total of 19 years after diagnosis. Psychiatric diagnoses were from Danish national registries. Patients were examined at the time of diagnosis and at a 6-year follow-up...
November 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29111211/myocardial-infarction-in-adults-with-congenital-heart-disease
#5
Morten Olsen, Bradley Marino, Jonathan Kaltman, Henning Laursen, Lars Jakobsen, William Mahle, Gail Pearson, Nicolas Madsen
We compared the incidence and 30-day mortality of myocardial infarction (MI) in adults with congenital heart disease (CHD) relative to the general population. This cohort study used nationwide population-based medical databases to identify individuals born before 1982 and diagnosed with CHD in Denmark between 1963 and 2012. Patients were followed for first-time MI using data from the Danish National Registry of Patients. For each subject with CHD, we identified 10 controls from the general population, matched by sex and birth year...
September 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29101144/charcot-marie-tooth-disease-in-denmark-a-nationwide-register-based-study-of-mortality-prevalence-and-incidence
#6
Signe Vaeth, Michael Vaeth, Henning Andersen, Rikke Christensen, Uffe Birk Jensen
OBJECTIVES: Charcot-Marie-Tooth disease (CMT) is the most common inherited disorder of the peripheral nervous system, yet no studies have compared the mortality in patients with CMT with that of the general population, and prevalence estimates vary considerably. We performed a nationwide register-based study to investigate the prevalence, incidence and mortality of CMT in Denmark. DESIGN: We used the Danish National Patient Registry to select all records with primary diagnostic codes for CMT between 1977 and 2012 given at a neurological, neurophysiological, paediatric or clinical genetic clinic...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29100862/association-between-diverticular-disease-and-abdominal-aortic-aneurysms-pooled-analysis-of-two-population-based-screening-cohorts
#7
Anders Mark-Christensen, Jes Sanddal Lindholt, Axel Diederichsen, Flemming Hald Steffensen, Martin Busk, Lars Frost, Grazina Urbonaviciene, Jess Lambrechtsen, Kenneth Egstrup, Søren Laurberg
BACKGROUND: The aetiology of abdominal aortic aneurysms (AAA) is multifactorial, and many risk factors are shared with diverticular disease. It is unknown whether an independent association exists between these conditions. METHODS: Individuals enrolled in two Danish population based randomised AAA screening trials and assigned to cross sectional screening and evaluation of cardiovascular risk factors were identified. Diagnoses of diverticular disease were interrogated from a national patient registry covering the period from 1977 to the screening date...
October 31, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29100750/oncocytic-carcinoma-of-the-salivary-glands-a-danish-national-study
#8
Marie Westergaard-Nielsen, Christian Godballe, Lisbeth Juhler Andersen, Hanne Primdahl, Claus A Kristensen, Elo Andersen, Kristine Bjørndal
OBJECTIVES: To present a Danish national series of oncocytic carcinoma (OC) patients, including data on treatment, recurrence and survival. METHODS: From the national Danish database of salivary gland carcinomas, all patients diagnosed with OC from 1990 to 2005 were identified and data concerning demographics, tumor site, clinical stage and treatment profiles were extracted. A follow-up was carried out. RESULTS: Of the 15 cases of salivary gland OC, eight were female...
October 31, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29080667/birth-outcomes-after-preconception-paternal-exposure-to-methotrexate-a-nationwide-cohort-study
#9
Rachel W Winter, Michael Due Larsen, Bjarne Magnussen, Sonia Friedman, Heidi Kammerlander, Bente Mertz Nørgård
BACKGROUND: Methotrexate (MTX), a folic acid antagonist, is often prescribed for moderate to severe inflammatory related diseases. The safety of paternal MTX use prior to conception is unknown. This study, using the National Danish Registries, aimed to examine the association between paternal MTX use three months before conception and adverse birth outcomes. RESULTS: Children fathered by men treated with MTX within three months before conception constituted the exposed cohort (N=193), and children fathered by men not treated with MTX constituted the unexposed cohort (N=1,013,801)...
October 30, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/29071499/lactase-persistence-milk-intake-and-mortality-in-the-danish-general-population-a-mendelian-randomization-study
#10
Helle Kirstine Mørup Bergholdt, Børge Grønne Nordestgaard, Anette Varbo, Christina Ellervik
Meta-analyses have suggested no association between milk intake and mortality. Since only few studies have been conducted, we investigated the association between the lactase persistent genetic variant LCT-13910 C/T (rs4988235), a proxy for long-term low and high intake of milk, and mortality. We used two Danish population-based studies with self-reported intake of milk and genotyping for LCT-13910 C/T. We obtained information on all-cause and cause-specific mortality (cardiovascular and cancer) from the national Danish registries...
October 25, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29066571/individual-testosterone-decline-and-future-mortality-risk-in-men
#11
Stine Agergaard Holmboe, Niels E Skakkebaek, Anders Juul, Thomas Scheike, Tina Kold Jensen, Allan Linneberg, Betina H Thuesen, Anna-Maria Andersson
OBJECTIVE: Male aging is characterized by a decline in testosterone (T) levels with a substantial variability between subjects. However, it is unclear whether differences in age-related changes in T are associated with general health. We investigated associations between mortality and intra-individual changes in serum levels of total T, SHBG, free T, estradiol and LH during a ten year period with up to 18 years of registry follow-up. DESIGN: 1,167 men aged 30 to 60 years participating in the Danish Monitoring Trends and Determinants of Cardiovascular Disease (MONICA1) study and who had a follow-up examination ten years later (MONICA10) were included...
October 24, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29059007/national-study-of-the-prevalence-of-gestational-diabetes-mellitus-among-danish-women-from-2004-to-2012
#12
Charlotte Jeppesen, Helle T Maindal, Jette K Kristensen, Per G Ovesen, Daniel R Witte
AIMS: The prevalence of gestational diabetes mellitus (GDM) is increasing worldwide. We studied the prevalence of GDM from 2004 to 2012 in Danish women aged 15-49 years using registries with records of the diagnosis of GDM at delivery. METHODS: We conducted a national register-based study of 12,538 women with a diagnosis of GDM during a pregnancy leading to a live birth in the period 2004-2012. The diagnosis of GDM was taken from the National Patient Registry and combined with the total number of births at the national level from Statistics Denmark...
October 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29057724/incidence-and-survival-of-oropharyngeal-cancer-in-denmark-a-nation-wide-population-based-study-from-1980-to-2014
#13
Jakob Schmidt Jensen, David Hebbelstrup Jensen, Christian Grønhøj, Kirstine Kim Schmidt Karnov, Cecilie Nørregaard, Tina Klitmøller Agander, Lena Specht, Christian von Buchwald
BACKGROUND: Oropharyngeal carcinomas (OPCs) constitute a significant and increasing proportion of head and neck carcinomas and are an important global cause of morbidity and mortality. The purpose of this study was to determine trends in incidence and survival in OPC in the Danish population from 1980 to 2014. METHODS: This study included all patients registered in the nationwide Danish Cancer Registry over the period 1980-2014. The age-adjusted incidence rates (AAIR) per 100,000, annual percentage change (APC) and average annual percent change (AAPC) were evaluated...
October 23, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29051022/impact-of-allogeneic-stem-cell-transplantation-in-first-complete-remission-in-acute-myelogenous-leukemia-a-national-population-based-cohort-study
#14
Lene Sofie Granfeldt Østgård, Jennifer L Lund, Jan Maxwell Nørgaard, Mette Nørgaard, Bruno C Medeiros, Bendt Nielsen, Ove Juul Nielsen, Ulrik Malthe Overgaard, Maria Kallenbach, Claus Werenberg Marcher, Anders Hammerich Riis, Henrik Sengeløv
To examine the outcomes of allogeneic stem cell transplantation (HSCT) in first complete remission (CR1) compared with chemotherapy alone in a population-based setting, we identified a cohort of patients with acute myelogenous leukemia (AML) aged 15 to 70 years diagnosed between 2000 and 2014 in Denmark. Using the Danish National Acute Leukemia Registry, we compared relapse risk, relapse-free survival (RFS), and overall survival (OS) between patients with unfavorable cytogenetic features receiving postremission therapy with conventional chemotherapy only versus those undergoing HSCT in CR1...
October 16, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29045908/long-term-exposure-to-residential-railway-and-road-traffic-noise-and-risk-for-diabetes-in-a-danish-cohort
#15
Nina Roswall, Ole Raaschou-Nielsen, Steen Solvang Jensen, Anne Tjønneland, Mette Sørensen
BACKGROUND: Road traffic noise exposure has been found associated with diabetes incidence. Evidence for an association between railway noise exposure is less clear, as large studies with detailed railway noise modelling are lacking. PURPOSE: To investigate the association between residential railway noise and diabetes incidence, and to repeat previous analyses on road traffic noise and diabetes with longer follow-up time. METHODS: Among 50,534 middle-aged Danes enrolled into the Diet, Cancer and Health cohort from 1993 to 97, we identified 5062 cases of incident diabetes during a median follow-up of 15...
October 15, 2017: Environmental Research
https://www.readbyqxmd.com/read/29030168/shiga-toxin-producing-escherichia-coli-incidence-and-clinical-features-in-a-setting-with-complete-screening-of-patients-with-suspected-infective-diarrhoea
#16
Rune Micha Pedersen, Marc Trunjer Kusk Nielsen, Sören Möller, Steen Ethelberg, Marianne Nielsine Skov, Hans Jørn Kolmos, Flemming Scheutz, Hanne Marie Holt, Flemming Schønning Rosenvinge
OBJECTIVES: Shiga toxin-producing Escherichia coli (STEC) causes diarrhoeal disease, bloody diarrhoea and haemolytic uraemic syndrome. The aim of this study was to describe the incidence of STEC and the clinical features of STEC patients from a well-defined Danish population in which all fecal samples of patients with suspected infective gastroenteritis were analysed for STEC. METHODS: In this population-based cohort study, all stool samples referred to two clinical microbiology laboratories, were screened for STEC by culture and/or PCR...
October 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29027840/male-factor-infertility-and-risk-of-multiple-sclerosis-a-register-based-cohort-study
#17
Clara Helene Glazer, Sandra Søgaard Tøttenborg, Aleksander Giwercman, Elvira Vaclavik Bräuner, Michael L Eisenberg, Ditte Vassard, Melinda Magyari, Anja Pinborg, Lone Schmidt, Jens Peter Bonde
BACKGROUND: Gender, possibly due to the influence of gonadal hormones, is presumed to play a role in the pathogenesis of multiple sclerosis (MS), but no studies have evaluated whether male infertility is associated with MS. OBJECTIVE: To study the association between male factor infertility and prevalent as well as incident MS. METHOD: Our cohort was established by linkage of the Danish National in vitro fertilization (IVF) registry to The Danish Multiple Sclerosis Registry and consisted of 51,063 men whose partners had undergone fertility treatment in all public and private fertility clinics in Denmark between 1994 and 2015...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29019614/associations-of-serum-potassium-levels-with-mortality-in-chronic-heart-failure-patients
#18
Mette Aldahl, Anne-Sofie Caroline Jensen, Line Davidsen, Matilde Alida Eriksen, Steen Møller Hansen, Berit Jamie Nielsen, Maria Lukács Krogager, Lars Køber, Christian Torp-Pedersen, Peter Søgaard
Aims: Medication prescribed to patients suffering from chronic heart failure carries an increased risk of impaired potassium homeostasis. We examined the relation between different levels of serum potassium and mortality among patients with chronic heart failure. Methods and results: From Danish National registries, we identified 19 549 patients with a chronic heart failure diagnosis who had a measurement of potassium within minimum 90 days after initiated medical treatment with loop diuretics and angiotensin converting enzyme inhibitors or angiotensin-II receptor blockers...
October 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28993421/burden-of-mortality-attributable-to-diagnosed-diabetes-a-nationwide-analysis-based-on-claims-data-from-65-million-people-in-germany
#19
Esther Jacobs, Annika Hoyer, Ralph Brinks, Oliver Kuss, Wolfgang Rathmann
OBJECTIVE: In Germany, as in many other countries, nationwide data on mortality attributable to diagnosed diabetes are not available. This study estimated the absolute number of excess deaths associated with diabetes (all types) and type 2 diabetes in Germany. RESEARCH DESIGN AND METHODS: A prevalence approach that included nationwide routine data from 64.9 million people insured in the German statutory health insurance system in 2010 was used for the calculation...
October 9, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28992159/compliance-with-accreditation-and-recommended-hospital-care-a-danish-nationwide-population-based-study
#20
Anne Mette Falstie-Jensen, Søren Bie Bogh, Erik Hollnagel, Søren Paaske Johnsen
Objective: To examine the association between compliance with accreditation and recommended hospital care. Design: A Danish nationwide population-based follow-up study based on data from six national, clinical quality registries between November 2009 and December 2012. Setting: Public, non-psychiatric Danish hospitals. Participants: Patients with acute stroke, chronic obstructive pulmonary disease, diabetes, heart failure, hip fracture and bleeding/perforated ulcers...
October 1, 2017: International Journal for Quality in Health Care
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