Matheus P S Magalhães-Gomes, Daisy Motta-Santos, Luana P L Schetino, Jéssica N Andrade, Cristiane P Bastos, Diogo A S Guimarães, Sydney K Vaughan, Patrícia M Martinelli, Silvia Guatimosim, Grace S Pereira, Candido C Coimbra, Vânia F Prado, Marco A M Prado, Gregorio Valdez, Cristina Guatimosim
Congenital myasthenic syndromes (CMS) result from reduced cholinergic transmission at neuromuscular junctions (NMJs). While the etiology of CMS varies, the disease is characterized by muscle weakness. To date, it remains unknown if CMS causes long-term and irreversible changes to skeletal muscles. In this study, we examined skeletal muscles in a mouse line with reduced expression of Vesicular Acetylcholine Transporter (VAChT, mouse line herein called VAChT-KDHOM ). We examined this mouse line for several reasons...
November 2018: Neurochemistry International