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https://www.readbyqxmd.com/read/27921430/-obstructive-sleep-apnoea-and-type-2-diabetes-mellitus
#1
Andrea Plíhalová, Kateřina Westlake, Jan Polák
Obstructive sleep apnoea syndrome (OSA) is a disease very frequently occurring in people with type 2 diabetes, that significantly increases cardiovascular morbidity and mortality. In a number of studies, OSA has been identified as an independent risk factor for the development of insulin resistance, glucose intolerance and type 2 diabetes mellitus. Disorders of glucose homeostasis in patients with OSA are probably mediated by chronic intermittent hypoxia and/or sleep fragmentation through activation of the sympathetic nervous system, the hypothalamic-pituitary-adrenal stress axis, pro-inflammatory paths or oxidative stress...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27920990/angiosarcoma-of-the-adrenal-gland-treated-using-a-multimodal-approach
#2
Jay G Fuletra, Benjamin T Ristau, Barton Milestone, Harry S Cooper, Alysia Browne, Sujana Movva, Thomas J Galloway, Randall Lee, Nikhil Waingankar, Alexander Kutikov
Angiosarcoma of the adrenal gland is an extremely rare malignancy. We report a case of a 59-year-old female who presented with abdominal pain and profound anemia. A 7 cm enhancing, lipid-poor adrenal mass with calcifications that extended posterior to the vena cava was identified on imaging. Patient underwent right adrenalectomy with retroperitoneal lymph node dissection. Pathology demonstrated angiosarcoma of the adrenal gland. Consolidative treatment included adjuvant radiation and chemotherapy. Patient remains disease free 1...
January 2017: Urology Case Reports
https://www.readbyqxmd.com/read/27920641/severe-de-novo-hepatitis-b-recovered-from-late-onset-liver-insufficiency-with-prolonged-ascites-and-hypoalbuminemia-due-to-hepatitis-b-virus-genotype-bj-with-precore-mutation
#3
Akira Sato, Toshiya Ishii, Fumiaki Sano, Takayuki Yamada, Hideaki Takahashi, Nobuyuki Matsumoto
De novo hepatitis B is associated with a high risk of hepatic failure often resulting in fatal fulminant hepatitis even when nucleotide analogues are administered. A 77-year-old female developed de novo hepatitis B after R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) treatment for diffuse large B-cell lymphoma. Hepatitis B virus (HBV) isolated from the patient was of genotype Bj, with a precore mutation (G1896A) exhibiting an extremely high viral load at the onset of hepatitis...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27920546/chronotherapy-with-low-dose-modified-release-prednisone-for-the-management-of-rheumatoid-arthritis-a-review
#4
REVIEW
Stefano Paolo Beltrametti, Aurora Ianniello, Clara Ricci
To date, rheumatoid arthritis (RA) remains a debilitating, life-threatening disease. One major concern is morning symptoms (MS), as they considerably impair the patients' quality of life and ability to work. MS change in a circadian fashion, resembling the fluctuations of inflammatory cytokines such as interleukin-6, whose levels are higher in RA patients compared to healthy donors. Conversely, serum levels of the potent anti-inflammatory glucocorticoid cortisol are similar to that of healthy subjects, suggesting an imbalance that sustains a pro-inflammatory state...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27920487/synchronous-occurrence-of-a-hepatic-myelolipoma-and-two-hepatocellular-carcinomas
#5
Shao-Yan Xu, Hai-Yang Xie, Lin Zhou, Shu-Sen Zheng, Wei-Lin Wang
Myelolipoma is a rare tumor composed of fat and bone marrow components, most of which are located in the adrenal gland. Myelolipoma in the liver is extremely rare. To date, only 10 cases have been reported in the English-language medical literature. In one of these cases, the hepatic myelolipoma was found within a hepatocellular carcinoma (HCC). In the present study, we report the first case of the synchronous occurrence of hepatic myelolipoma and HCCs in different liver sections of one patient, a 26-year-old female who was admitted to our hospital because of a 4-d history of upper abdominal pain...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27919363/the-effects-of-statin-treatment-on-adrenal-and-sexual-function-and-nitric-oxide-levels-in-hypercholesterolemic-male-patients-treated-with-a-statin
#6
Osman Baspınar, Fahri Bayram, Selda Korkmaz, Murat Aksu, Derya Kocer, Oğuzhan Sıtkı Dizdar, Yasin Simsek, Peter P Toth
BACKGROUND: Erectile dysfunction complaints among men treated with a statin are not uncommon. OBJECTIVES: To evaluate the effect of lowering low-density lipoprotein cholesterol (LDL-C) to target levels using varying doses of atorvastatin therapy in hypercholesterolemic male patients on adrenocortical hormones, sexual functions, and serum nitric oxide (NO) levels. METHODS: Eleven hypercholesterolemic male patients who had LDL-C levels greater than 160 mg/dL were included in the study and 11 healthy male individuals served as controls...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27919252/neoplastic-diseases-in-the-domestic-ferret-mustela-putorius-furo-in-italy-classification-and-tissue-distribution-of-856-cases-2000-2010
#7
Giancarlo Avallone, Annalisa Forlani, Marco Tecilla, Elena Riccardi, Sara Belluco, Sara Francesca Santagostino, Guido Grilli, Kiumars Khadivi, Paola Roccabianca
BACKGROUND: The aim of this study was to describe the prevalence and tissue distribution of neoplasms in Italian ferrets, compared to the epidemiological data previously reported in USA and Japan. METHODS: Signalment and diagnoses of pathological submissions received between 2000 and 2010 were searched; cases with the diagnosis of neoplasm were selected and original sections reviewed to confirm the diagnosis. RESULTS: Nine-hundred and ten samples were retrieved, 690 of which included at least one tumour for a total of 856 tumours...
December 5, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27919124/-rupture-of-adrenal-artery-aneurysm-a-case-report
#8
Naofumi Tsutsumi, Ayumu Matsuda, Hiroshi Iwamura, Tetsuo Washio
A 45-year-old man with severe left flank pain was brought by ambulance to our hospital early in the morning. On arrival, his circulation dynamics were stable. His urinalysis results were normal, and ultrasonography showed no hydronephrosis. Abdominal dynamic computed tomography (CT) showed a huge retroperitoneal hematoma suspected of hemorrhage from a left adrenal artery aneurysm. After 3 hours of absolute bed rest, the patient experienced episodes of anemia, decreased blood pressure and increased pulse. Recheck of CT showed bleeding into the peritoneal cavity...
October 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27919009/successful-percutaneous-ct-guided-microwave-ablation-of-adrenal-gland-for-ectopic-cushing-syndrome
#9
Rebecca Zener, Andrew Zaleski, Stan H Van Uum, Daryl K Gray, Amol Mujoomdar
Adrenocorticotropic hormone production by pancreatic neuroendocrine tumor (PNET) is rare and results in hyperstimulation of the adrenal gland to produce ectopic Cushing syndrome. Our case showcases the safety and effectiveness of percutaneous CT-guided microwave ablation of the adrenal gland in a 49-year-old female with PNET and hepatic metastases who presented with ectopic Cushing syndrome despite surgical resection of the primary pancreatic tumor and left adrenal gland. Prior to ablation, the right adrenal gland measured 4...
November 29, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27917115/switching-adolescent-high-fat-diet-to-adult-control-diet-restores-neurocognitive-alterations
#10
Chloé Boitard, Shauna L Parkes, Amandine Cavaroc, Frédéric Tantot, Nathalie Castanon, Sophie Layé, Sophie Tronel, Gustavo Pacheco-Lopez, Etienne Coutureau, Guillaume Ferreira
In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive and emotional outcomes. Its growing prevalence in adolescents is particularly alarming since this is a period of ongoing maturation for brain structures (including the hippocampus and amygdala) and for the hypothalamic-pituitary-adrenal (HPA) stress axis, which is required for cognitive and emotional processing. We recently demonstrated that adolescent, but not adult, high-fat diet (HF) exposure leads to impaired hippocampal function and enhanced amygdala function through HPA axis alteration (Boitard et al...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27917104/thirty-eight-year-follow-up-of-two-sibling-lipoid-congenital-adrenal-hyperplasia-patients-due-to-homozygous-steroidogenic-acute-regulatory-stard1-protein-mutation-molecular-structure-and-modeling-of-the-stard1-l275p-mutation
#11
Khalil Khoury, Elie Barbar, Youssef Ainmelk, Annie Ouellet, Pierre Lavigne, Jean-Guy LeHoux
Objective: Review the impact of StAR (STARD1) mutations on steroidogenesis and fertility in LCAH patients. Examine the endocrine mechanisms underlying the pathology of the disorder and the appropriate therapy for promoting fertility and pregnancies. Design: Published data in the literature and a detailed 38-year follow-up of two sibling LCAH patients. Molecular structure and modeling of the STARD1 L275P mutation. Setting: University hospital. Patients: Patient A (46,XY female phenotype) and patient B (46,XX female) with LCAH bearing the L275P mutation in STARD1...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27916659/stronger-hypothalamus-pituitary-adrenal-axis-habituation-predicts-lesser-sensitization-of-inflammatory-response-to-repeated-acute-stress-exposures-in-healthy-young-adults
#12
Myriam V Thoma, Danielle Gianferante, Luke Hanlin, Alexander Fiksdal, Chen Xuejie, Nicolas Rohleder
Effective adjustment of the stress systems to repeated stress is regarded as an adaptive response of the organism facing environmental threats. Given the intertwined relationship between the stress systems and the inflammatory system, it could be expected that inflammatory processes should adapt to repeated stress as well. However, only little is known about adaptational processes of the different components of the immune system in response to repeated stress, and how these might be related to adaptational processes of the hypothalamus-pituitary-adrenal (HPA) axis...
December 1, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27916140/moderate-alcohol-consumption-after-a-mental-stressor-attenuates-the-endocrine-stress-response
#13
I C Schrieks, M M Joosten, W A A Klöpping-Ketelaars, R F Witkamp, H F J Hendriks
Alcohol is often consumed to reduce tension and improve mood when exposed to stressful situations. Previous studies showed that moderate alcohol consumption may reduce stress when alcohol is consumed prior to a stressor, but data on the effect of alcohol consumption after a mental stressor is limited. Therefore, our objective was to study whether moderate alcohol consumption immediately after a mental stressor attenuates the stress response. Twenty-four healthy men (age 21-40 y, BMI 18-27 kg/m(2)) participated in a placebo-controlled trial...
December 2016: Alcohol
https://www.readbyqxmd.com/read/27914933/differential-synthesis-and-release-of-il-18-and-il-18-binding-protein-from-human-platelets-and-their-implications-for-hiv-infection
#14
Ossama Allam, Suzanne Samarani, Mohammad-Ali Jenabian, Jean-Pierre Routy, Cecile Tremblay, Devendra Amre, Ali Ahmad
IL-18 is a pro-inflammatory cytokine belonging to the IL-1 family and is produced in the body from macrophages, epithelial and dendritic cells, keratinocytes, adrenal cortex etc. The cytokine is produced as an inactive precursor that is cleaved inside cells into its mature form by activated caspase 1, which exists as an inactive precursor in human cells and requires assembly of an inflammasomes for its activation. We show here for the first time that human platelets contain transcripts for the IL-18 gene. They synthesize the cytokine de novo, process and release it upon activation...
December 1, 2016: Cytokine
https://www.readbyqxmd.com/read/27914245/perinatal-hypothalamic-pituitary-adrenal-axis-regulation-among-women-with-eating-disorders-and-their-infants
#15
A Easter, E Taborelli, A Bye, P A Zunszain, C M Pariante, J Treasure, U Schmidt, N Micali
BACKGROUND: Psychiatric illness is associated with heightened hypothalamic-pituitary-adrenal (HPA) axis activity during pregnancy which may have long term effects on infant stress regulation. HPA axis regulation has not previously been investigated in women with eating disorders (ED) or their infants during the perinatal period. METHODS: Women were recruited to a prospective longitudinal study in three groups: 1) current or active ED (C-ED=31), 2) past ED (P-ED=29) and healthy control (HC=57)...
November 11, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27913781/synchronous-microscopic-epstein-barr-virus-positive-diffuse-large-b-cell-lymphoma-of-the-adrenal-and-lymphoplasmacytic-lymphoma-de-novo-disease-or-transformation
#16
Mufaddal T Moonim, Alia Nasir, Jonathan Hubbard, Nicholas Ketley, Paul Fields
Lymphomas arising in the adrenal are rare, and to our knowledge, 2 cases of Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphomas (DLBCL) in an adrenal pseudocyst have been reported. We report an incidental EBV-positive DLBCL arising in an adrenal pseudocyst in a 58-year-old man with a 7-year history of lymphoplasmacytic lymphoma (LPL). The DLBCL was present in the fibrinous exudate, while the LPL resided in the cyst wall. The patient underwent de-roofing of the same cyst 3 years previously; review of histology revealed foci of LPL in the cyst wall, but not of DLBCL...
December 2, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27913572/very-low-density-lipoprotein-vldl-induced-signals-mediating-aldosterone-production
#17
Ying-Ying Tsai, William E Rainey, Wendy B Bollag
Aldosterone, secreted by the adrenal zona glomerulosa, enhances sodium retention, thus increasing blood volume and pressure. Excessive production of aldosterone results in high blood pressure, and contributes to cardiovascular and renal disease, stroke, and visual loss. Hypertension is also associated with obesity, which s correlated with other serious health risks as well. Although weight gain is associated with increased blood pressure, the mechanism by which excess fat deposits increase blood pressure remains unclear...
December 2, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27908897/cortisol-as-a-predictor-of-psychological-therapy-response-in-depressive-disorders-systematic-review-and-meta-analysis
#18
REVIEW
Susanne Fischer, Rebecca Strawbridge, Andres Herane Vives, Anthony J Cleare
BACKGROUND: Many patients with depressive disorders demonstrate resistance to psychological therapy. A frequent finding is hypothalamic-pituitary-adrenal (HPA) axis alterations. As cortisol is known to modulate cognitive processes, those patients may be less likely to profit from psychological therapy. AIMS: To conduct a systematic review and meta-analysis on cortisol as a predictor of psychological therapy response. METHOD: The Cochrane Library, EMBASE, MEDLINE and PsycINFO databases were searched...
December 1, 2016: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/27908768/acute-stress-diminishes-m-current-contributing-to-elevated-activity-of-hypothalamic-pituitary-adrenal-axis
#19
Jing-Jing Zhou, Yonggang Gao, Therese A Kosten, Zongmao Zhao, De-Pei Li
Acute stress stimulates corticotrophin-releasing hormone (CRH)-expressing neurons in the hypothalamic paraventricular nucleus (PVN), which is an essential component of hypothalamic-pituitary-adrenal (HPA) axis. However, the cellular and molecular mechanisms remain unclear. The M-channel is a voltage-dependent K(+) channel involved in stabilizing the neuronal membrane potential and regulating neuronal excitability. In this study, we tested our hypothesis that acute stress suppresses expression of Kv7 channels to stimulate PVN-CRH neurons and the HPA axis...
November 28, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27908659/public-exposure-and-number-of-conspecifics-have-no-influence-on-ovarian-and-adrenal-activity-in-the-cheetah-acinonyx-jubatus
#20
Diana C Koester, David E Wildt, Janine L Brown, Karen Meeks, Adrienne E Crosier
Cheetahs in managed zoological collections do not reproduce efficiently, a problem that may be related to environmental/management stressors. In this study, we examined 17 adult female cheetahs to determine the influence of two environmental factors, (1) being housed on- or off-exhibit and (2) number of adult conspecifics (males and/or females) in nearby enclosures, on profiles and concentrations of ovarian and adrenal hormones. Secondarily, we assessed a subset of group-housed siblings (n = 5 in groups of 2 or 3) for effects of long-term cohabitation...
November 28, 2016: General and Comparative Endocrinology
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