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Omeprazole AND glp-1

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https://www.readbyqxmd.com/read/24145087/combination-of-omeprazole-with-glp-1-agonist-therapy-improves-insulin-sensitivity-and-antioxidant-activity-in-liver-in-type-1-diabetic-mice
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Vishal Patel, Amit Joharapurkar, Nirav Dhanesha, Samadhan Kshirsagar, Jaysukh Detroja, Kartikkumar Patel, Tejal Gandhi, Kirti Patel, Rajesh Bahekar, Mukul Jain
BACKGROUND: Combination with suitable pharmacological agents can improve the antiobesity and antidiabetic actions of glucagon like peptide-1 (GLP-1) based therapies. GLP-1 agonist exendin-4 may have insulin-independent effects on amelioration of insulin resistance and hepatic steatosis by virtue of its action on hepatic GLP-1 receptors, and these effects can be improved by combination with proton pump inhibitors. However, it was not assessed whether omeprazole can improve the peripheral actions of exendin-4 in the state of insulin deficiency...
2013: Pharmacological Reports: PR
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