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Metabolic syndrome antipsychotic

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https://www.readbyqxmd.com/read/28096874/prevalence-of-metabolic-syndrome-in-patients-with-schizophrenia-in-korea-a-multicenter-nationwide-cross-sectional-study
#1
Jung Sun Lee, Jun Soo Kwon, Daeho Kim, Sung-Wan Kim, Jae-Jin Kim, Jong-Hoon Kim, Hee Jung Nam, Seunghyong Ryu, Il Ho Park, Suk Kyoon An, Hong-Seok Oh, Seunghee Won, Kanguk Lee, Kyu Young Lee, Seung-Hwan Lee, Yu Sang Lee, Jung-Seo Yi, Kyung Sue Hong, Yeon Ho Joo
OBJECTIVE: We designed a nationwide study with limited exclusion criteria to investigate the prevalence of metabolic syndrome (MetS) in Korea and its relationship with antipsychotic medications. METHODS: This multicenter, cross-sectional, and observational study included patients diagnosed with schizophrenia or schizoaffective disorder. Sixteen hospitals enrolled 845 patients aged 18 to 65 years prescribed any antipsychotic medication between August 2011 and August 2013...
January 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28093900/who-is-responsible-for-metabolic-screening-for-mental-health-clients-taking-antipsychotic-medications
#2
Tamara Ward, Dianne Wynaden, Karen Heslop
Metabolic syndrome is common in mental health consumer populations, and is linked to cardiovascular disease, stroke and diabetes. Metabolic screening is a way of recognising consumers who are at risk of developing metabolic syndrome but internationally screening rates remain low. A retrospective audit was completed at one Australian public mental health service on the case files of 100 randomly selected consumers to determine nurses level of compliance with metabolic screening policies over a 12 month period...
January 17, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28076676/use-of-metformin-for-cardiometabolic-risks-in-psychiatric-practice-need-to-know-safety-issues
#3
Chittaranjan Andrade
Metformin, a biguanide drug, is emerging as an important treatment option for the prevention or treatment of weight gain, type 2 diabetes mellitus, and the metabolic syndrome in psychiatric patients, especially those who require or receive antipsychotic drugs. Metformin treatment is commonly associated with gastrointestinal adverse effects; the risk of these is reduced by gradual dose uptitration, administration of the drug with meals, and use of a time-release formulation. Lactic acidosis, a potentially fatal complication of biguanide therapy, is very rare with metformin; the risk can be reduced by avoidance of its prescription in patients with impaired renal function, impaired liver function, cardiac failure, and certain other conditions...
November 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28074349/second-generation-antipsychotic-utilization-and-metabolic-parameter-monitoring-in-an-inpatient-pediatric-population-a-retrospective-analysis
#4
Valerie D Nolt, Alexandra Victoria Kibler, G Lucy Wilkening, Tanya J Fabian
BACKGROUND: Second-generation antipsychotics (SGAs) are prescribed for a variety of indications and are strongly associated with adverse metabolic effects. Studies of pediatric outpatients have revealed several deficiencies in monitoring practices for adverse effects associated with SGAs. OBJECTIVE: Our objective was to characterize SGA prescribing and metabolic parameter monitoring (MPM) in an inpatient pediatric population. METHODS: Patients aged <18 years and discharged on SGA treatment between 1 November 2013 and 30 April 2014 from an inpatient psychiatric institution in Pittsburgh, PA, USA were included...
January 10, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28049080/metabolic-syndrome-or-glucose-challenge-in-first-episode-of-psychosis
#5
C Garcia-Rizo, E Fernandez-Egea, C Oliveira, A Meseguer, B Cabrera, G Mezquida, M Bioque, R Penades, E Parellada, M Bernardo, B Kirkpatrick
Patients with schizophrenia exhibit a reduced life expectancy. Although unhealthy lifestyle or suicide risk plays a role, the main causes are diverse medical conditions such as cardiovascular diseases, type 2 diabetes mellitus and metabolic syndrome. Albeit pharmacological secondary side effects might also trigger previous conditions, studies in naïve patients reflect diverse anomalies at the onset. Patients with a first episode of psychosis, display a wide scope of metabolic abnormalities, ranging from normality till pathological values depending on the parameters studied...
December 30, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28000544/the-complex-inter-relationship-between-diabetes-and-schizophrenia
#6
Jeffery Rado
Schizophrenia is a chronic and debilitating brain disorder. It is associated with increased mortality, primarily due to elevated cardio-metabolic risk. Affected patients have higher rates of obesity, metabolic syndrome and diabetes [1]. Intrinsic factors contributing to this increased risk include a shared underlying pathophysiology between schizophrenia and diabetes mellitus involving stress, inflammation and genetics. Extrinsic contributing factors include diet, lifestyle, health care access, low socioeconomic status and overburden of traditional diabetes risk factors...
December 20, 2016: Current Diabetes Reviews
https://www.readbyqxmd.com/read/27978821/metabolic-syndrome-and-adverse-clinical-outcomes-in-patients-with-bipolar-disorder
#7
Ya-Mei Bai, Cheng-Ta Li, Shih-Jen Tsai, Pei-Chi Tu, Mu-Hong Chen, Tung-Ping Su
BACKGROUND: Metabolic syndrome (MetS) is highly prevalent among patients with bipolar disorder. MetS may cause complications in the brain, but studies investigating MetS-associated clinical psychiatric outcomes remain scant. METHODS: We enrolled clinically stable outpatients with bipolar disorder aged 18-65 years and performed anthropometric and fasting biochemical assessments to investigate MetS prevalence. We then performed clinical assessments by using the Young Mania Rating Scale for manic symptoms, the Montgomery-Åsberg Depression Rating Scale for depressive symptoms, the Positive and Negative Symptom Scale for psychotic symptoms, the Involuntary Movement Scale for tardive dyskinesia, the Barnes Akathisia Rating Scale for akathisia, the Udvalg for Kliniske Undersogelser for general side effects, the Schedule for Assessment of Insight for insight, the Global Assessment of Functioning scale for global functioning, and the Wisconsin Card Sorting Test (WCST) for cognitive executive function...
December 15, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27941732/glycosylated-hemoglobin-in-different-levels-of-bmi
#8
R K Das, A Nessa, M Asrin, M Z Huq, M F Husain, S Sufrin, R Zannat, T Tajkia
Body mass index is an inexpensive and easy method of screening for weight categories that may lead to health problems. Increased BMI in overweight and obese persons is directly associated with an increase in metabolic disease, such as type 2 diabetes mellitus. This Analytical cross sectional study was undertaken to assess the relation between increasing BMI and glycemic control of body through measuring glycosylated hemoglobin. This study was carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh from July 2011 to June 2012 on 180 equally divided male and female persons between the age of 25 to 55 years...
October 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27939025/metabolic-syndrome-and-atypical-antipsychotics-possibility-of-prediction-and-control
#9
Clara M Franch Pato, Vicente Molina Rodríguez, Juan I Franch Valverde
INTRODUCTION: Schizophrenia and other psychotic disorders are associated with high morbidity and mortality, due to inherent health factors, genetic factors, and factors related to psychopharmacological treatment. Antipsychotics, like other drugs, have side-effects that can substantially affect the physical health of patients, with substantive differences in the side-effect profile and in the patients in which these side-effects occur. To understand and identify these risk groups could help to prevent the occurrence of the undesired effects...
December 6, 2016: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/27898069/clozapine-modifies-the-differentiation-program-of-human-adipocytes-inducing-browning
#10
E Kristóf, Q-M Doan-Xuan, A K Sárvári, Á Klusóczki, P Fischer-Posovszky, M Wabitsch, Z Bacso, P Bai, Z Balajthy, L Fésüs
Administration of second-generation antipsychotic drugs (SGAs) often leads to weight gain and consequent cardio-metabolic side effects. We observed that clozapine but not six other antipsychotic drugs reprogrammed the gene expression pattern of differentiating human adipocytes ex vivo, leading to an elevated expression of the browning marker gene UCP1, more and smaller lipid droplets and more mitochondrial DNA than in the untreated white adipocytes. Laser scanning cytometry showed that up to 40% of the differentiating single primary and Simpson-Golabi-Behmel syndrome (SGBS) adipocytes had the characteristic morphological features of browning cells...
November 29, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27888958/improving-metabolic-syndrome-screening-on-patients-on-second-generation-antipsychotic-medication
#11
Esther Kioko, Kimberly Williams, Beth Newhouse
AIM: This quality improvement project aims at stressing the importance of screening for metabolic syndrome (MS) on patients with serious mental illness (SMI) managed with second generation antipsychotic (SGA) medication. METHOD: One hundred charts of patients who were on SGA (n=100) were randomly selected from more than 1000 charts for the purpose of this project with (n=50) charts for pre-intervention and (n=50) charts for post intervention. A chi-square test of independence was calculated comparing the frequency of labs and vital done in pre-intervention and post-intervention period...
December 2016: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/27871720/-guidelines-for-the-prescription-of-mood-stabilizers-for-adolescents-a-literature-review
#12
G Munch, N Godart
INTRODUCTION: Adolescence is a unique phase of the human developmental process. In adolescents, psychotropic medications may have different efficacy and tolerance profiles compared to those at other stages of the lifespan. Mood stabilizers are a complex pharmacological category including lithium, some anticonvulsants, and some second generation antipsychotics. Focusing on this class of pharmacological agents, we aim to answer the following questions: in which indications and according to which modalities should mood stabilizers be prescribed during adolescence? METHODS: Information was sought from the websites of the French Haute Autorité de santé (HAS) and Agence nationale de sécurité du médicament et des produits de santé (ANSM), the American Food and Drug Administration (FDA) and the British National Institute for Health and Clinical Excellence (NICE)...
November 18, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27863522/cardiometabolic-health-prescribed-antipsychotics-and-health-related-quality-of-life-in-people-with-schizophrenia-spectrum-disorders-a-cross-sectional-study
#13
Daniel Bressington, Jolene Mui, Mei Ling Tse, Richard Gray, Eric F C Cheung, Wai Tong Chien
BACKGROUND: People with schizophrenia-spectrum disorders (SSD) often have high levels of obesity and poor cardiometabolic health. Certain types of antipsychotics have been shown to contribute towards weight gain and there is some equivocal evidence that obesity is related to poor health-related quality of life (HRQoL) in people with SSD. It is also still uncertain if antipsychotic polypharmacy/higher doses of antipsychotics are linked with HRQoL and/or increased risk of obesity/Cardiovascular Disease (CVD)...
November 18, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27846426/metabolic-outcomes-of-bergamot-polyphenolic-fraction-administration-in-patients-treated-with-second-generation-antipsychotics-a-pilot-study
#14
Antonio Bruno, Gianluca Pandolfo, Manuela Crucitti, Antonino Maisano, Rocco A Zoccali, Maria Rosaria Anna Muscatello
Second-generation antipsychotics (SGAs) are notoriously associated with a marked increase in body weight and with a wide range of metabolic adverse effects, and their chronic use is related with an increased risk for the development of metabolic syndrome (MS). Different adjunctive treatments have been proposed to reduce SGAs-induced weight gain and/or metabolic abnormalities with inconsistent or too limited evidence to support their regular clinical use, thus suggesting the need to find new possible treatments...
October 22, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27845774/serum-metabolite-profile-associates-with-the-development-of-metabolic-co-morbidities-in-first-episode-psychosis
#15
T Suvitaival, O Mantere, T Kieseppä, I Mattila, P Pöhö, T Hyötyläinen, J Suvisaari, M Orešič
Psychotic patients are at high risk for developing obesity, metabolic syndrome and type 2 diabetes. These metabolic co-morbidities are hypothesized to be related to both treatment side effects as well as to metabolic changes occurring during the psychosis. Earlier metabolomics studies have shown that blood metabolite levels are predictive of insulin resistance and type 2 diabetes in the general population as well as sensitive to the effects of antipsychotics. In this study, we aimed to identify the metabolite profiles predicting future weight gain and other metabolic abnormalities in psychotic patients...
November 15, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27828697/aripiprazole-induced-hyperlipidemia-an-update
#16
Caroline Tarraf, Wadih J Naja
OBJECTIVE: To review the literature on the metabolic side effects of aripiprazole. Three cases of aripiprazole-induced hypertriglyceridemia are also presented. DATA SOURCES: A search was conducted of English-language articles and abstracts (meta-analyses, randomized controlled trials, clinical trials, naturalistic open-label trials, reviews, and case reports) published up to August 31, 2014, in electronic databases (PubMed, MEDLINE). STUDY SELECTION: Free-text and MeSH search keywords included aripiprazole, cholesterol, triglyceride, lipid profile, hyperlipidemia, and hypercholesterolemia and their differing terminations and combinations...
August 25, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27811553/sex-differences-in-body-mass-index-and-obesity-in-chinese-patients-with-chronic-schizophrenia
#17
Qiongzhen Li, Dachuan Chen, Tiebang Liu, Consuelo Walss-Bass, Joao L de Quevedo, Jair C Soares, Jingping Zhao, Xiang Yang Zhang
Sex differences in schizophrenia have been well recognized. However, sex differences in obesity associated with antipsychotics have received little systematic study. This study was conducted to compare sex difference effects of antipsychotics and related risk factors on obesity and body mass index (BMI) in Chinese patients with schizophrenia. A total of 204 inpatients with chronic schizophrenia (males/females = 140/66) were recruited. Demographic and clinical data were collected, and serum glucose and lipid levels were measured...
December 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27807604/safety-and-tolerability-of-cariprazine-in-the-long-term-treatment-of-schizophrenia-results-from-a-48-week-single-arm-open-label-extension-study
#18
Suresh Durgam, William M Greenberg, Dayong Li, Kaifeng Lu, Istvan Laszlovszky, Gyorgy Nemeth, Raffaele Migliore, Stephen Volk
RATIONALE: Cariprazine, a dopamine D3/D2 receptor partial agonist antipsychotic, demonstrated efficacy and tolerability in 6-week, randomized, placebo-controlled schizophrenia trials. Schizophrenia is a chronic disorder that requires continuous treatment; therefore, the long-term safety and tolerability profile of antipsychotic agents is an important factor in guiding clinician decisions. OBJECTIVE: This single-arm, open-label extension study evaluated the long-term safety and tolerability of cariprazine in patients with schizophrenia...
January 2017: Psychopharmacology
https://www.readbyqxmd.com/read/27751654/prevalence-of-metabolic-syndrome-in-female-and-male-patients-at-risk-of-psychosis
#19
Joachim Cordes, Andreas Bechdolf, Christina Engelke, Kai G Kahl, Chakrapani Balijepalli, Christian Lösch, Joachim Klosterkötter, Michael Wagner, Wolfgang Maier, Andreas Heinz, Walter de Millas, Wolfgang Gaebel, Georg Winterer, Birgit Janssen, Christian Schmidt-Kraepelin, Frank Schneider, Martin Lambert, Georg Juckel, Thomas Wobrock, Michael Riedel, Susanne Moebus
Metabolic Syndrome (MetS) is one of the most common factors underlying the high rate of mortality observed in patients with schizophrenia. Recent research on this topic revealed that many of the patients studied were, in fact, in a medicated state. As such, it is unclear whether MetS is causally associated with the disorder itself or the medication used to treat it. In this study, patients with a clinically high risk of expressing first episode psychosis (CHR) were examined regarding the prevalence of MetS...
October 14, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27733953/predictors-of-calf-arterial-compliance-in-male-veterans-with-psychiatric-diagnoses
#20
Maju Mathew Koola, John D Sorkin, Molly Fargotstein, W Virgil Brown, Bruce Cuthbert, Jeffrey Hollis, Jeffrey K Raines, Erica J Duncan
BACKGROUND: Peripheral arterial compliance (PAC) is a measure of the ability of the vascular tree to dilate in response to a pressure wave. Reduced PAC is seen in patients with psychiatric diagnoses and has been associated with increased risk for stroke, myocardial infarction, and mortality. The objective of this pilot study was to identify predictors of reduced PAC in subjects with psychiatric diagnoses. METHODS: Male psychiatric subjects (N = 77) were studied in a cross-sectional study of medication effects on PAC conducted from August 2005 to February 2010...
2016: Primary Care Companion to CNS Disorders
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