keyword
MENU ▼
Read by QxMD icon Read
search

Metabolic syndrome antipsychotic

keyword
https://www.readbyqxmd.com/read/29893366/metformin-for-antipsychotic-related-metabolic-syndrome-in-children-fact-or-fiction
#1
Ahmed Naguy, Dalal El-Sori
No abstract text is available yet for this article.
June 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29871707/remission-of-depression-in-patients-with-schizophrenia-and-comorbid-major-depressive-disorder-results-from-the-face-sz-cohort
#2
Guillaume Fond, Laurent Boyer, Fabrice Berna, Ophélia Godin, Ewa Bulzacka, Méja Andrianarisoa, Lore Brunel, Bruno Aouizerate, Delphine Capdevielle, Isabelle Chereau, Nathalie Coulon, Thierry D'Amato, Caroline Dubertret, Julien Dubreucq, Catherine Faget, Sylvain Leignier, Christophe Lançon, Jasmina Mallet, David Misdrahi, Christine Passerieux, Romain Rey, Aurélie Schandrin, Mathieu Urbach, Pierre Vidailhet, Marion Leboyer, Franck Schürhoff, Pierre-Michel Llorca
BACKGROUND: Major depressive disorder (MDD) is underdiagnosed and undertreated in schizophrenia, and has been strongly associated with impaired quality of life.AimsTo determine the prevalence and associated factors of MDD and unremitted MDD in schizophrenia, to compare treated and non-treated MDD. METHOD: Participants were included in the FondaMental Expert Centers for Schizophrenia and received a thorough clinical assessment. MDD was defined by a Calgary score ≥6...
June 6, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29850476/the-influence-of-metabolic-syndrome-and-sex-on-the-dna-methylome-in-schizophrenia
#3
Kyle J Burghardt, Jacyln M Goodrich, Brittany N Lines, Vicki L Ellingrod
Introduction: The mechanism by which metabolic syndrome occurs in schizophrenia is not completely known; however, previous work suggests that changes in DNA methylation may be involved which is further influenced by sex. Within this study, the DNA methylome was profiled to identify altered methylation associated with metabolic syndrome in a schizophrenia population on atypical antipsychotics. Methods: Peripheral blood from schizophrenia subjects was utilized for DNA methylation analyses...
2018: International Journal of Genomics
https://www.readbyqxmd.com/read/29845615/metabolic-syndrome-and-actigraphy-measures-of-sleep-and-circadian-rhythms-in-bipolar-disorders-during-remission
#4
H Brochard, O Godin, P A Geoffroy, S Yeim, C Boudebesse, C Benizri, V Benard, J Maruani, M Leboyer, F Bellivier, B Etain
OBJECTIVE: This study explored the correlations between sleep and circadian rhythm measures and the metabolic syndrome (MetS) components in remitted patients with bipolar disorder (BD). METHOD: Euthymic patients with BD (n = 67) were recorded by 3 weeks with actigraphy. We used nonparametric correlations to study the links between the MetS parameters, atherogenic index of plasma (AIP), sleep efficacy, sleep latency, fragmentation index, and phase and amplitude of rhythms...
May 30, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29808267/chronic-low-grade-peripheral-inflammation-is-associated-with-ultra-resistant-schizophrenia-results-from-the-face-sz-cohort
#5
G Fond, O Godin, L Boyer, F Berna, M Andrianarisoa, N Coulon, L Brunel, E Bulzacka, B Aouizerate, D Capdevielle, I Chereau, T D'Amato, C Dubertret, J Dubreucq, C Faget, S Leignier, C Lançon, J Mallet, D Misdrahi, C Passerieux, R Rey, A Schandrin, M Urbach, P Vidailhet, P M Llorca, F Schürhoff, M Leboyer
A high rate of patients with schizophrenia (SZ) does not sufficiently respond to antipsychotic medication, which is associated with relapses and poor outcomes. Chronic peripheral inflammation has been repeatedly associated with schizophrenia risk and particularly to poor responders to treatment as usual with cognitive impairment in SZ subjects. The objective of present study was to confirm if ultra resistance to treatment in schizophrenia (UTRS) was associated to chronic peripheral inflammation in a non-selected sample of community-dwelling outpatients with schizophrenia...
May 28, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29791666/prevalence-of-polymorphisms-in-the-ankk1-drd2-drd3-genes-and-metabolic-syndrome-in-refractory-schizophrenia
#6
Jeizziani Aparecida Ferreira Pinto, Pedro Henrique Batista de Freitas, Fernanda Daniela Dorneles Nunes, Paulo Afonso Granjeiro, Luciana Lara Dos Santos, Richardson Miranda Machado
OBJECTIVE: to estimate the prevalence of TaqIA, -141C and rs6280 polymorphisms of the ANKK1, DRD2 and DRD3 genes and evaluate their association with the occurrence of metabolic syndrome in patients with refractory schizophrenia. METHOD: cross-sectional study conducted in the Extended Western Region of Minas Gerais, with refractory schizophrenic patients using the antipsychotic clozapine. Sociodemographic, clinical, anthropometric, biochemical and genetic data were collected...
2018: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29740394/metabolic-syndrome-and-antipsychotics-the-role-of-mitochondrial-fission-fusion-imbalance
#7
Andrea Del Campo, Catalina Bustos, Carolina Mascayano, Claudio Acuña-Castillo, Rodrigo Troncoso, Leonel E Rojo
Second-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There are limited prophylactic interventions to prevent these side effects of SGAs, in part because the molecular mechanisms underlying SGAs toxicity are not yet completely elucidated. In this perspective article, we introduce an innovative approach to study the metabolic side effects of antipsychotics through the alterations of the mitochondrial dynamics, which leads to an imbalance in mitochondrial fusion/fission ratio and to an inefficient mitochondrial phenotype of muscle cells...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29731635/antidopaminergic-medication-in-healthy-subjects-provokes-subjective-and-objective-mental-impairments-tightly-correlated-with-perturbation-of-biogenic-monoamine-metabolism-and-prolactin-secretion
#8
Tanja Veselinović, Ingo Vernaleken, Paul Cumming, Uwe Henning, Lina Winkler, Peter Kaleta, Michael Paulzen, Christian Luckhaus, Gerhard Gründer
Objectives: Off-label prescription of antipsychotics to patients without psychotic symptoms has become a routine matter for many psychiatrists and also some general practitioners. Nonetheless, little is known about the possibly detrimental effects of antidopaminergic medications on general psychopathology, subjective mental state, or a possible association with physiological parameters in nonpsychotic individuals. Methods: In this randomized, single-blinded study, groups of healthy volunteers (n=18) received low doses of reserpine, aripiprazole, haloperidol, or placebo on 7 successive days...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29707086/epigenetics-of-metabolic-syndrome-as-a-mood-disorder
#9
REVIEW
Sermin Kesebir
Mood disorders comprise major depressive disorder (MDD), bipolar disorder (BD) and the milder forms of these two disorders. Reccurring MDD is also known as unipolar disorder. The distinction between unipolar and bipolar disorders was first suggested in 1957 by Leonard and was made official after support by several studies in 1980. Indeed, in 150 AD, Aretaeus of Cappadocia wrote "It seems to me that melancholia is the beginning and a part of mania". Additionally, Kraepelin, who proposed the first medical disease model in psychiatry a century ago, considered recurrent unipolar depression cases under the category of bipolar disorder and conceptualized spectrum disorders...
June 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29609929/red-yeast-rice-ryr-supplementation-in-patients-treated-with-second-generation-antipsychotics
#10
Antonio Bruno, Gianluca Pandolfo, Manuela Crucitti, Giulia Maria Troili, Edoardo Spina, Rocco Antonio Zoccali, Maria Rosaria Anna Muscatello
OBJECTIVE: Second-generation antipsychotics (SGAs) have a negative impact on metabolic syndrome (MetS) risk factors for their effects on body weight and on metabolic parameters. Statins are widely used in the treatment of dyslipidemia; less is known on the ability of statins to treat SGAs-induced dyslipidemia, and nutraceutical approaches may represent promising strategies in SGAs-treated patients. Red Yeast Rice (RYR), the fermented product of the Aspergillaceae mold Monascus purpureus (red yeast) grown on white rice, has been shown to have a cholesterol-lowering effect which can be ascribed to monacolin K, although other active compounds may play a role management of hyperlipidemia...
April 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29593413/serum-levels-of-%C3%AE-hydroxybutyrate-and-pyruvate-metabolic-changes-and-cognitive-function-in-patients-with-schizophrenia-during-antipsychotic-treatment-a-preliminary-study
#11
Yu-Chi Huang, Pao-Yen Lin, Yu Lee, Chi-Fa Hung, Su-Ting Hsu, Chih-Ching Wu, Liang-Jen Wang
Background: β-hydroxybutyrate (β-HB) and pyruvate have been associated with the brain energy utilization, which may play a role in the pathophysiology of schizophrenia. In this prospective study, we aim to investigate the trends of β-HB and pyruvate levels, metabolic changes, and cognitive function in schizophrenia patients receiving antipsychotic treatment. Objective: We recruited 38 schizophrenia patients who had been treated with antipsychotics for 12 weeks, as well as 38 healthy age- and gender-matched subjects...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29587717/the-prevalence-of-metabolic-syndrome-in-patients-receiving-antipsychotics-in-qatar-a-cross-sectional-comparative-study
#12
Samer Hammoudeh, Suhaila Ghuloum, Ziyad Mahfoud, Arij Yehya, Abdulmoneim Abdulhakam, Azza Al-Mujalli, Mahmoud Al-Zirie, Mohamed Osman Abdel Rahman, Angela Godwin, Noura Younes, Yahya Hani, Dennis Mook-Kanamori, Marjonneke Mook-Kanamori, Reem El Sherbiny, Hassen Al-Amin
BACKGROUND: Metabolic abnormalities are common in patients maintained on antipsychotics. These abnormalities increase the risk of cardiovascular diseases and mortality in this population. The aim of this study is to assess the prevalence of metabolic syndrome (MetS) in subjects maintained on antipsychotics relative to controls in Qatar, and to assess the factors contributing to the development of MetS. METHODS: A cross sectional design was used to collect data and fasting blood samples from subjects maintained on antipsychotics for at least six months (n = 112) and from a control group (n = 114)...
March 27, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29587340/genetic-variations-associated-with-sleep-disorders-in-patients-with-schizophrenia-a-systematic-review
#13
REVIEW
Konstantinos Assimakopoulos, Katerina Karaivazoglou, Maria Skokou, Marina Kalogeropoulou, Panagiotis Kolios, Philippos Gourzis, George P Patrinos, Evangelia Eirini Tsermpini
Background: Schizophrenic patients commonly suffer from sleep disorders which are associated with acute disease severity, worsening prognoses and a poorer quality of life. Research is attempting to disentangle the complex interplay between schizophrenia and sleep disturbances by focusing not only on demographic and clinical characteristics, but also on the identification of genetic factors. Methods: Here, we performed a systematic literature review on the topic of genetic variations in sleep-disordered schizophrenic patients in an attempt to identify high quality investigations reporting scientifically sound and clinically useful data...
March 24, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29564285/a-case-report-of-rapid-onset-hyponatremia-induced-by-low-dose-olanzapine
#14
Sethulakshmi Sreevalsam Anil, Badr Ratnakaran, Nisha Suresh
Hyponatremia has been reported with the use of psychotropic drugs. Olanzapine does not find much mention as a cause of hyponatremia in literature; however, it has been found to be the second most frequently reported atypical antipsychotic to cause it. We report a case of hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion which occurred at a rapid onset following the administration of low-dose olanzapine during inpatient treatment of a patient with bipolar disorder. We would like to highlight our case for the need to be vigil about such fatal side complications apart from metabolic side effects of atypical antipsychotics...
October 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29522591/-hypokalemic-rhabdomyolisis-and-schizophrenia
#15
Natalia Fantacone, Edgardo Carísimo, Pablo Landi, Eden Del Mar Walsöe, Daniel Fadel
The purpose of this report is to emphasize the necessity to periodically explore internal environment variables, as certain metabolic alterations often go unnoticed during antipsychotic treatment. Early detection of such alterations may prevent catastrophic syndromes. We will also stress the clinical relevance of cognitive perseverations in schizophrenic patients, as these often condition habits of consumption which can alter the internal environment. In this clinical case of a schizophrenic patient, a chain of events led to a catastrophic syndrome: a trivial home accident (fall from own height) developed into a condition characterized by oligoanuria, hypokalemia, creatine phosphokinase (CPK) elevation (125,000 IU / L) and acute renal failure with dialysis requirement...
July 2017: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/29519756/effects-of-cannabis-use-on-body-mass-fasting-glucose-and-lipids-during-the-first-12-months-of-treatment-in-schizophrenia-spectrum-disorders
#16
F Scheffler, S Kilian, B Chiliza, L Asmal, L Phahladira, S du Plessis, M Kidd, R M Murray, M Di Forti, S Seedat, R Emsley
While acute cannabis use stimulates appetite, general population studies suggest that chronic use is associated with reduced risk of obesity and other cardiometabolic risk factors. In this study we investigated changes in body mass index (BMI), fasting blood glucose and lipids, and rates of metabolic syndrome risk factors in cannabis users vs. non-users in 109 minimally treated patients with first-episode schizophrenia, schizophreniform or schizo-affective disorder who were treated according to a standardized treatment regime with depot antipsychotic medication over 12 months...
March 6, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29486959/cardio-metabolic-risk-and-its-management-in-a-cohort-of-clozapine-treated-outpatients
#17
Julia Margaret Lappin, Marlene Wijaya, Andrew Watkins, Rachel Morell, Scott Teasdale, Oscar Lederman, Simon Rosenbaum, Stephanie Dick, Philip Ward, Jackie Curtis
OBJECTIVE: To comprehensively assess cardio-metabolic risk factors and their management in a large sample of outpatients treated with clozapine. METHODS: Observational cross-sectional study of all clozapine users attending specialized clozapine monitoring outpatient clinics in three public hospitals in Sydney, Australia were approached to participate over the one-year period 01/10/2015-30/09/2016. Cardio-metabolic risk factors including metabolic syndrome, risk for future development of diabetes, smoking, physical activity, nutrition, and prescribed medications were assessed at face-to-face interview and through medical record review...
February 24, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29479787/cardiometabolic-risks-and-omega-3-index-in-recent-onset-bipolar-i-disorder
#18
Lawson R Wulsin, Thomas J Blom, Michelle Durling, Jeffrey A Welge, Melissa P DelBello, Caleb M Adler, Robert K McNamara, Stephen M Strakowski
OBJECTIVES: The aims of the present study were to characterize cardiometabolic risk factors in a cohort of bipolar disorder patients with limited exposure to psychotropic medications, and to evaluate their associations with mood symptoms and omega-3 polyunsaturated fatty acid (PUFA) blood levels. METHODS: Cardiometabolic risk assessments were compared in individuals with bipolar I disorder experiencing a first manic or mixed episode or an early depressive episode (n=117) and healthy subjects (n=56)...
February 26, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29477703/latent-toxoplasma-gondii-infection-is-associated-with-decreased-serum-triglyceride-to-high-density-lipoprotein-cholesterol-ratio-in-male-patients-with-schizophrenia
#19
Marina Sagud, Suzana Vlatkovic, Dubravka Svob Strac, Mario Sviben, Maja Zivkovic, Maja Vilibic, Bjanka Vuksan-Cusa, Alma Mihaljevic-Peles, Nela Pivac
BACKGROUND: Previous studies suggested a complex association between Toxoplasma gondii (TG) infection and host lipid metabolism. Both TG infection and metabolic disturbances are very common in patients with schizophrenia, but this relationship is not clear. METHODS: In this cross-sectional study, we evaluated the association between TG seropositivity, serum lipid levels, body mass index (BMI) and metabolic syndrome (MetS) in 210 male inpatients with schizophrenia...
April 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29449054/second-generation-antipsychotic-induced-mitochondrial-alterations-implications-for-increased-risk-of-metabolic-syndrome-in-patients-with-schizophrenia
#20
Giselli Scaini, João Quevedo, Dawn Velligan, David L Roberts, Henriette Raventos, Consuelo Walss-Bass
Metabolic syndrome (MetS) is seen more frequently in persons with schizophrenia than in the general population, and these metabolic abnormalities are further aggravated by second generation antipsychotic (SGA) drugs. Although the underlying mechanisms responsible for the increased prevalence of MetS among patients under SGA treatment are not well understood, alterations in mitochondria function have been implicated. We performed a comprehensive evaluation of the role of mitochondrial dysfunction in the pathophysiology of drug-induced MetS in schizophrenia...
March 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
keyword
keyword
73394
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"