keyword
MENU ▼
Read by QxMD icon Read
search

MIMIC

keyword
https://www.readbyqxmd.com/read/28231580/pediatric-hangman-s-fracture-a-comprehensive-review
#1
Michael Montalbano, Christian Fisahn, Marios Loukas, Rod J Oskouian, Jens R Chapman, R Shane Tubbs
PURPOSE: Over 170 years ago, traumatic spondylolisthesis of the axis or hangman's fracture was described. Most descriptions of this entity have focused on adult presentations. METHODS: We review the literature on pediatric cases of hangman's fracture emphasizing the embryological as well as presentation aspects. RESULTS: The majority of cervical spine fractures in children occur at C1 and C2 vertebrae. A normal anterolisthesis of C2 can be seen in younger children and can mimic the anterolisthesis seen after traumatic spondylolisthesis...
February 24, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28231547/nonmonotonic-responses-to-low-doses-of-xenoestrogens-a-review
#2
REVIEW
Zhixiang Xu, Jun Liu, Xinhao Wu, Bin Huang, Xuejun Pan
Xenoestrogens (XEs) mimic or block the synthesis, metabolism and transport of normal endogenous hormones, disturbing normal endocrine function. The available data on the nonmonotonic estrogenic effects of low doses of many XEs are reviewed, covering in vitro, in vivo and epidemiological studies. The observed nonmonotonic patterns of the dose-response curves are discussed, along with possible underlying mechanisms. This review is intended to provide guidance for harm predication and to suggest prevention measures...
February 20, 2017: Environmental Research
https://www.readbyqxmd.com/read/28231532/paeonifiorin-sulfonate-as-a-characteristic-marker-for-specifically-inspecting-chinese-patent-medicine-liu-wei-di-huang-wan-contained-sulfur-fumigated-moutan-cortex
#3
Xiu-Yang Li, Fang Long, Jin-Di Xu, Hong Shen, Ming Kong, He Zhu, Ye-Qing Zhang, Song-Lin Li
Sulfur fumigation can induce chemical transformation of bioactive components, consequently the alteration of bioactivities or even toxicities of medicinal herbs. Inspecting Chinese patent medicines (CPM) contained sulfur-fumigated constituent herbs is crucial for ensuring the safety and efficacy of CPM. Paeonifiorin sulfonate is a sulfur-fumigation induced compound of Moutan Cortex (MC), one of the main constituent herbs of a commonly used CPM Liu-Wei-Di-Huang-Wan (LWDHW). Herein, we investigated the approach of paeonifiorin sulfonate as a characteristic marker for specifically inspecting LWDHW potentially contained sulfur-fumigated MC (SFMC)...
February 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28230904/effects-of-re-heating-tissue-samples-to-core-body-temperature-on-high-velocity-ballistic-projectile-tissue-interactions
#4
Caitlin Humphrey, Maciej Henneberg, Christian Wachsberger, Nicholas Maiden, Jaliya Kumaratilake
Damage produced by high-speed projectiles on organic tissue will depend on the physical properties of the tissues. Conditioning organic tissue samples to human core body temperature (37°C) prior to conducting ballistic experiments enables their behavior to closely mimic that of living tissues. To minimize autolytic changes after death, the tissues are refrigerated soon after their removal from the body and re-heated to 37°C prior to testing. This research investigates whether heating 50-mm-cube samples of porcine liver, kidney, and heart to 37°C for varying durations (maximum 7 h) can affect the penetration response of a high-speed, steel sphere projectile...
February 23, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28230151/potential-microbial-contamination-during-sampling-of-permafrost-soil-assessed-by-tracers
#5
Toke Bang-Andreasen, Morten Schostag, Anders Priemé, Bo Elberling, Carsten S Jacobsen
Drilling and handling of permanently frozen soil cores without microbial contamination is of concern because contamination e.g. from the active layer above may lead to incorrect interpretation of results in experiments investigating potential and actual microbial activity in these low microbial biomass environments. Here, we present an example of how microbial contamination from active layer soil affected analysis of the potentially active microbial community in permafrost soil. We also present the development and use of two tracers: (1) fluorescent plastic microspheres and (2) Pseudomonas putida genetically tagged with Green Fluorescent Protein production to mimic potential microbial contamination of two permafrost cores...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229971/breviscapine-suppresses-the-growth-of-non-small-cell-lung-cancer-by-enhancing-microrna-7-expression
#6
Jian Zeng, Shunv Cai
Breviscapine (BVP) has previously been shown to inhibit the proliferation of hepatocellular carcinoma cells. However, little is known about the effects of BVP on non-small cell lung cancer (NSCLC) growth. Here, we aimed to study the effects of BVP on human NSCLC growth. We employed A549, NCL-H460 and A549 cells transfected with microRNA-7 (miR-7) mimic and inhibitor to investigate the effect of BVP on cell proliferation, apoptosis and apoptosis-associated molecules. The results showed that BVP significantly reduced the growth of A549 and NCLH460 cells in a concentration-dependent and time-dependent manner, accompanied by a significant elevation of apoptosis...
March 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/28229398/stroke-chameleons-and-stroke-mimics-in-the-emergency-department
#7
REVIEW
Ava L Liberman, Shyam Prabhakaran
PURPOSE OF REVIEW: We discuss the frequency of stroke misdiagnosis in the emergency department (ED), identify common diagnostic pitfalls, describe strategies to reduce diagnostic error, and detail ongoing research. RECENT FINDINGS: The National Academy of Medicine has re-defined and highlighted the importance of diagnostic errors for patient safety. Recent rates of stroke under-diagnosis (false-negative cases, "stroke chameleons") range from 2-26% and 30-43% for stroke over-diagnosis (false-positive cases, "stroke mimics")...
February 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28228635/mir-3202-promoted-h5v-cell-apoptosis-by-directly-targeting-fas-apoptotic-inhibitory-molecule-2-faim2-in-high-glucose-condition
#8
Xiaozhong Huang, Hui Xie, Guanhua Xue, Meng Ye, Lan Zhang
BACKGROUND Vascular complications are a major concern for patients with diabetes. Endothelial cells (ECs) play a key role in vascular function. MicroRNAs (miRNAs) have been shown to play an important role in mediating EC function; miRNAs are vulnerable to hyperglycemic conditions. Previous reports verified that Fas apoptotic inhibitory molecule 2 (FAIM2) can inhibit cell apoptosis through repressing the FAS-associated death domain protein (FADD) pathway. This current study was designed to explore the potential involvement of miR-3202 in the pathogenesis of ECs in high-glucose conditions...
February 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28228617/silkworm-fungal-infection-model-for-identification-of-virulence-genes-in-pathogenic-fungus-and-screening-of-novel-antifungal-drugs
#9
Masaki Ishii, Yasuhiko Matsumoto, Ikuko Nakamura, Kazuhisa Sekimizu
The silkworm infection model has the potential to replace conventional animal models for evaluation of the efficacy and toxicity of investigational antifungal agents. Silkworms are relatively inexpensive, can be simply grown in large numbers and can be easily infected with pathogenic fungi, including mutant strains. Antifungal agents can then be injected into the silkworm either via the hemolymph to mimic intravenous administration or directly into the gut for oral administration, and their antifungal effect can be evaluated...
February 21, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28228589/capsid-phosphorylation-state-and-hepadnavirus-virion-secretion
#10
Xiaojun Ning, Suresh H Basagoudanavar, Kuancheng Liu, Laurie Luckenbaugh, Duoqian Wei, Chunyan Wang, Bo Wei, Yingren Zhao, Taotao Yan, William Delaney, Jianming Hu
The C-terminal domain (CTD) of hepadnavirus core protein is involved in multiple steps of viral replication. In particular, CTD is initially phosphorylated at multiple sites to facilitate viral RNA packaging into immature nucleocapsids (NCs) and the early stage of viral DNA synthesis. For the avian hepadnavirus, the duck hepatitis B virus (DHBV), CTD is dephosphorylated subsequently to facilitate the late stage of viral DNA synthesis and to stabilize NCs containing mature viral DNA. The role of CTD phosphorylation in virion secretion, if any, has remained unclear...
February 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28228548/contact-guidance-requires-spatial-control-of-leading-edge-protrusion
#11
G R Ramirez-San Juan, P W Oakes, M L Gardel
In vivo, geometric cues from the extra-cellular matrix (ECM) are critical for the regulation of cell shape, adhesion and migration. During contact guidance, the fibrillar architecture of the ECM promotes an elongated cell shape and migration along the fibrils. The subcellular mechanisms by which cells sense ECM geometry and translate it into changes in shape and migration direction, are not understood. Here, we pattern linear fibronectin features to mimic fibrillar ECM and elucidate the mechanisms of contact guidance...
February 22, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28228421/randomized-clinical-trial-in-vitamin-d-deficient-adults-comparing-replenishment-with-oral-vitamin-d3-with-narrow-band-uv-type-b-light-effects-on-cholesterol-and-the-transcriptional-profiles-of-skin-and-blood
#12
Manish P Ponda, Yupu Liang, Jaehwan Kim, Richard Hutt, Kathleen Dowd, Patricia Gilleaudeau, Mary M Sullivan-Whalen, Tori Rodrick, Dong Joo Kim, Irina Barash, Michelle A Lowes, Jan L Breslow
Background: Vitamin D deficiency, defined as a serum 25-hydroxyvitamin D [25(OH)D] concentration <20 ng/mL, is correlated with a more atherogenic lipid profile. However, oral vitamin D supplementation does not lower LDL-cholesterol concentrations or raise HDL-cholesterol concentrations. This uncoupling between association and causation may result from a failure of oral vitamin D to mimic the effect of dermally synthesized vitamin D in response to ultraviolet type B (UVB) light.Objective: We tested the hypothesis that, in vitamin D-deficient adults, the replenishment of vitamin D with UVB exposure would lower LDL-cholesterol concentrations compared with the effect of oral vitamin D3 supplementation...
February 22, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28228295/idiopathic-dilatation-of-pulmonary-artery-a-review
#13
REVIEW
Amit Malviya, Pravin K Jha, Jyoti P Kalita, Manuj K Saikia, Animesh Mishra
The diagnosis of idiopathic dilatation of pulmonary artery is challenging because its clinical recognition is difficult and various other causes of dilated pulmonary artery need to be excluded. The clinical findings mimic various common cardiac disorders and both invasive and non-invasive investigations should be done to arrive at the diagnosis. It is a known clinical entity but etiology and pathophysiology are largely unknown. The current echocardiographic and catheterization based diagnostic criteria, may not be satisfied completely in a particular patient and need to be revisited in view of newer imaging modalities...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28228215/hnrnpk-regulated-ptov1-as1-modulates-heme-oxygenase-1-expression-via-mir-1207-5p
#14
Chang Hoon Shin, Seongho Ryu, Hyeon Ho Kim
Antisense transcripts were initially identified as transcriptional noise, but have since been reported to play an important role in the quality control of miRNA functions. In this report, we tested the hypothesis that hnRNPK regulates miRNA function via competitive endogenous RNAs, such as pseudogenes, long non-coding RNAs, and antisense transcripts. Based on analyses of RNA sequencing data, the knockdown of hnRNPK decreased antisense PTOV1-AS1 transcript, which harbors five binding sites for miR-1207-5p. We identified heme oxygenase-1 (HO-1) mRNA as a novel target of miR-1207-5p by western blotting and Ago2 immunoprecipitation...
February 23, 2017: BMB Reports
https://www.readbyqxmd.com/read/28227882/development-and-application-of-human-breast-phantoms-in-microwave-diagnostic-and-therapeutic-technologies
#15
Luz Maria Neira, R Owen Mays, Susan C Hagness, Luz Maria Neira, R Owen Mays, Susan C Hagness, Luz Maria Neira, Susan C Hagness, R Owen Mays
We highlight recent progress in the development of high-fidelity numerical and physical breast phantoms. These phantoms mimic the anatomical structure and physical properties that are relevant to accurately portraying microwave interactions with the human breast. The phantoms are currently being used in numerous laboratory studies of microwave diagnostic and therapeutic technologies for a variety of potential clinical applications in breast health and disease management.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227542/biologically-inspired-multi-layered-synthetic-skin-for-tactile-feedback-in-prosthetic-limbs
#16
Luke Osborn, Harrison Nguyen, Joseph Betthauser, Rahul Kaliki, Nitish Thakor, Luke Osborn, Harrison Nguyen, Joseph Betthauser, Rahul Kaliki, Nitish Thakor, Joseph Betthauser, Luke Osborn, Nitish Thakor, Rahul Kaliki, Harrison Nguyen
The human body offers a template for many state-of-the-art prosthetic devices and sensors. In this work, we present a novel, sensorized synthetic skin that mimics the natural multi-layered nature of mechanoreceptors found in healthy glabrous skin to provide tactile information. The multi-layered sensor is made up of flexible piezoresistive textiles that act as force sensitive resistors (FSRs) to convey tactile information, which are embedded within a silicone rubber to resemble the compliant nature of human skin...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227484/design-of-peripheral-edema-measurement-device-for-home-use
#17
Stephanie M George, Brandon D Langley, Elizabeth M B Weaver, Sonya R Hardin, Jianchu Yao, Stephanie M George, Brandon D Langley, Elizabeth M B Weaver, Sonya R Hardin, Jianchu Yao, Brandon D Langley, Elizabeth M B Weaver, Jianchu Yao, Sonya R Hardin, Stephanie M George
Due to improvements in cardiovascular care, more patients are living longer but ultimately developing heart failure. It is important for patients with chronic conditions, like heart failure, to self-manage and monitor their symptoms. One symptoms that can be indicative of worsening heart failure is peripheral edema. Therefore, we present a concept for a HeartSMART system capable of edema measurement in the home with remote connection to and feedback from providers. The goal of the system is to provide a tool for heart failure patients to manage their disease...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227347/an-eemd-pca-approach-to-extract-heart-rate-respiratory-rate-and-respiratory-activity-from-ppg-signal
#18
Mohammod Abdul Motin, Chandan Kumar Karmakar, Marimuthu Palaniswami, Mohammod Abdul Motin, Chandan Kumar Karmakar, Marimuthu Palaniswami, Marimuthu Palaniswami, Mohammod Abdul Motin, Chandan Kumar Karmakar
The pulse oximeter's photoplethysmographic (PPG) signals, measure the local variations of blood volume in tissues, reflecting the peripheral pulse modulated by cardiac activity, respiration and other physiological effects. Therefore, PPG can be used to extract the vital cardiorespiratory signals like heart rate (HR), respiratory rate (RR) and respiratory activity (RA) and this will reduce the number of sensors connected to the patient's body for recording vital signs. In this paper, we propose an algorithm based on ensemble empirical mode decomposition with principal component analysis (EEMD-PCA) as a novel approach to estimate HR, RR and RA simultaneously from PPG signal...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227298/extracting-dielectric-spectroscopic-properties-from-microwave-induced-thermoacoustic-signals
#19
Shiyu Liu, Hao Nan, Nemat Dolatsha, Amin Arbabian, Shiyu Liu, Hao Nan, Nemat Dolatsha, Amin Arbabian, Hao Nan, Nemat Dolatsha, Amin Arbabian, Shiyu Liu
Available data on the dielectric properties of biological tissue across a frequency range adds an extra degree of freedom of contrast besides the baseline structural information obtained by conventional imaging techniques. In this paper, we propose a new methodology to non-invasively extract the normalized effective conductivity of samples over a large frequency range using microwave-induced thermoacoustic (TA) signals. Additionally, a calibration approach has been adopted to remove the frequency dependency of the experimental setup errors as well as the RF power variation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227144/optimal-medication-dosing-from-suboptimal-clinical-examples-a-deep-reinforcement-learning-approach
#20
Shamim Nemati, Mohammad M Ghassemi, Gari D Clifford, Shamim Nemati, Mohammad M Ghassemi, Gari D Clifford, Gari D Clifford, Mohammad M Ghassemi
Misdosing medications with sensitive therapeutic windows, such as heparin, can place patients at unnecessary risk, increase length of hospital stay, and lead to wasted hospital resources. In this work, we present a clinician-in-the-loop sequential decision making framework, which provides an individualized dosing policy adapted to each patient's evolving clinical phenotype. We employed retrospective data from the publicly available MIMIC II intensive care unit database, and developed a deep reinforcement learning algorithm that learns an optimal heparin dosing policy from sample dosing trails and their associated outcomes in large electronic medical records...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
keyword
keyword
7339
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"