keyword
https://read.qxmd.com/read/11554808/blood-pressure-changes-induced-by-arterial-blood-withdrawal-influence-bold-signal-in-anesthesized-rats-at-7-tesla-implications-for-pharmacologic-mri
#21
JOURNAL ARTICLE
R Kalisch, G K Elbel, C Gössl, M Czisch, D P Auer
Functional magnetic resonance imaging (fMRI) using the blood oxygenation level-dependent (BOLD) contrast is now increasingly applied for measuring drug effects on brain activity. A possible confound in pharmacologic fMRI (phMRI) is that the BOLD signal may be sensitive to systemic cardiovascular or respiratory parameters, which can themselves be modulated by a drug. To assess whether abrupt changes in arterial blood pressure (BP) as may be observed in phMRI experiments influence the BOLD signal, a hemorrhage model was studied in anesthesized rats at 7 T using spin-echo EPI...
October 2001: NeuroImage
https://read.qxmd.com/read/11447325/the-mc4-receptor-mediates-alpha-msh-induced-release-of-nucleus-accumbens-dopamine
#22
JOURNAL ARTICLE
J Lindblom, B Opmane, F Mutulis, I Mutule, R Petrovska, V Klusa, L Bergström, J E Wikberg
Strong evidence suggests a functional link between the melanocortin and dopamine systems. alpha-Melanocyte stimulating hormone (alpha-MSH) induced grooming behaviour, which can be blocked by dopamine receptor antagonists, is associated with increased dopaminergic transmission in the striatal regions. Whether this effect is mediated specifically by melanocortin (MC) receptors has not previously been established. Using in vivo microdialysis on anesthesized rats we have shown that alpha- MSH administered into the ventral tegmental area induced a significant increase in dopamine and DOPAC levels in the nucleus accumbens...
July 20, 2001: Neuroreport
https://read.qxmd.com/read/10800360/-systematic-recording-of-perioperative-events-associated-with-anesthesia-as-quality-indicator-in-ambulatory-anesthesia
#23
JOURNAL ARTICLE
R García-Aguado, M Vivó Benlloch, M J Arcusa Mon, C Peiró Alós, C Zaragoza Fernández, S Castaño Conesa, F Grau Real
OBJECTIVES: To analyze the quality of several anesthetic techniques used for major outpatient surgery in our hospital, by quantifying for each the relative risk (RR) of adverse events during anesthesia and in the postoperative period. PATIENTS AND METHODS: One thousand seventeen patients who underwent surgery between 18 May 1998 and 23 October 1998 were studied retrospectively. RESULTS: The mean age of the patients was 52.27 +/- 24.65 yr; 44...
March 2000: Revista Española de Anestesiología y Reanimación
https://read.qxmd.com/read/10187004/medical-relief-mission-to-bosnia-hercegovina-a-case-report
#24
JOURNAL ARTICLE
J R Tryon
World attention has been focused on Bosnia/Hercegovina, where war erupted in 1992. The regional hospital of Mostar, an industrial city with a population of 100,000, operated with chronic shortages of medical supplies including general anesthetic agents. In February 1992, just prior to the referendum for independence in that republic, a shipment of medical supplies with anesthesics, food, and clothing was delivered safely to Ljubuski, a village near Mostar, for Mostar hospital and surrounding clinics by a small, private organization from Birmingham, Alabama...
April 1997: Prehospital and Disaster Medicine
https://read.qxmd.com/read/9028797/intratracheal-instillation-versus-intratracheal-inhalation-of-tracer-particles-for-measuring-lung-clearance-function
#25
JOURNAL ARTICLE
G Oberdörster, C Cox, R Gelein
Effective elimination of particles deposited in the respiratory tract is an important defense function to protect the organism from potentially adverse effects of inhaled particles. Delivery of radioactively labeled tracer particles and subsequent measurement in vivo of their retention in different regions of the respiratory tract provides an adequate method for characterizing this defensive function. However, the delivery of such tracer particles by inhalation may result in some external contamination of the animals and requires specific protective measures while working with radioactive aerosols...
January 1997: Experimental Lung Research
https://read.qxmd.com/read/8919652/effects-of-beraprost-sodium-and-prostaglandin-e1-on-skin-blood-flow-in-diabetic-rats-and-normal-dogs
#26
COMPARATIVE STUDY
Y Ueno, N Yamada, H Koike, S Nishio
1. The present study was undertaken to compare the effects of beraprost sodium (BPS), a stable prostaglandin I2 analog, with prostaglandin E1 (PGE1) on the skin blood flow in anesthesized diabetic rats and anesthetized dogs. 2. In anesthetized diabetic rats, BPS, but not PGE1, caused a dose-dependent and significant increase in femoral skin blood flow. 3. In anesthetized dogs, PGE1 significantly increased femoral arterial blood flow than BPS. However, BPS significantly increased in-step skin blood flow than PGE1...
March 1996: General Pharmacology
https://read.qxmd.com/read/8752191/value-of-systolic-pulmonary-venous-flow-reversal-and-color-doppler-jet-measurements-assessed-with-transesophageal-echocardiography-in-recognizing-severe-pure-mitral-regurgitation
#27
JOURNAL ARTICLE
E P Pieper, I M Hellemans, H P Hamer, A C Ravelli, E C Cheriex, J G Tijssen, K I Lie, C A Visser
We evaluated the value of color and pulsed Doppler transesophageal echocardiographic parameters and of V waves in estimating the severity of mitral regurgitation (MR) in 62 consecutive patients (38 men and 24 women, aged 39 to 80 years) with angiographically proven chronic pure MR (15 grade I/II, 47 grade III/IV). Twenty patients were examined before cardiac surgery under general anesthesia. Sensitivity, specificity, and positive and negative predictive values of systolic pulmonary venous flow reversal for the presence of grade III/IV MR were 87%, 93%, 98%, and 64%, respectively, these were for jet areas > or = 8...
August 15, 1996: American Journal of Cardiology
https://read.qxmd.com/read/8602897/5-ht1d-receptors-regulate-5-ht-release-in-the-rat-raphe-nuclei-in-vivo-voltammetry-and-in-vitro-superfusion-studies
#28
JOURNAL ARTICLE
G Piñeyro, C de Montigny, P Blier
The aim of the present study was to characterize the pharmacological profile of 5-hydroxytryptamine (5-HT) receptors modulating 5-HT release in the mesencephalic raphe region. In a first series of experiments, differential normal pulse voltammetry and nafion-coated electrodes were used to measure extracellular 5-HT in the dorsal raphe of anesthesized rats. The intravenous administration of the selective 5-HT1A agonist 8-OH-DPAT (30 micrograms/kg) and the 5-HT1 agonist TFMPP (0.5 mg/kg) reduced the 5-hydroxyindole signal by 23% and 18%, respectively...
November 1995: Neuropsychopharmacology
https://read.qxmd.com/read/8318238/regional-versus-general-anesthesia-for-bone-marrow-harvesting
#29
COMPARATIVE STUDY
A Lavi, R Efrat, E Feigin, A Kadari
STUDY OBJECTIVE: To compare regional versus general anesthesia for bone marrow harvesting. DESIGN: Retrospective study. SETTING: Inpatients at a bone marrow transplantation unit of a university medical center. PATIENTS: One hundred sixty-two donors: 63 healthy patients donating heterologous marrow, 99 patients donating autologous marrow. INTERVENTIONS: Anesthesia and patient charts from 1986 to 1990 were reviewed...
May 1993: Journal of Clinical Anesthesia
https://read.qxmd.com/read/8246683/relationship-between-cyclic-amp-content-regional-myocardial-function-and-o2-consumption-in-experimental-left-ventricular-hypertrophy-effect-of-negative-inotropes
#30
JOURNAL ARTICLE
P M Scholz, W C Chiu, J Kedem, H R Weiss
The aim of this study was to examine the hypothesis that negative inotropic agents that lower myocyte cyclic-AMP by different means would have similar effects on local myocardial segment work and O2 consumption in control hearts, but that this response would differ in left ventricular hypertrophy (LVH) induced by aortic valve stenosis. Open chest anesthesized LVH and control dogs were studied before and during esmolol (100 micrograms/kg/min) and acetylcholine (100 micrograms/kg/min) infusion. Regional work was calculated as the integrated product of instantaneous force (miniature transducer) and shortening (sonomicrometry) per min...
1993: Life Sciences
https://read.qxmd.com/read/8242881/alterations-in-renal-gluconeogenesis-and-blood-flow-during-hemorrhagic-shock
#31
JOURNAL ARTICLE
S R Maitra, W Pan, E R Geller, M C Henry
The role of renal gluconeogenesis following hemorrhagic shock was studied. Hemorrhagic shock was induced in fasted, anesthesized rats by reduction of blood pressure to 40 mm Hg for either 30 or 150 min. Plasma samples were obtained for plasma glucose determination, and right renal arterial blood flow was determined with the help of an ultrasonic transit time blood flowmeter in hemorrhagic shock and control rats. The kidney was perfused via the renal artery with 37 degrees C oxygenated, glucose-free Krebs-Henseleit solution in the presence of 100 microM phloridzin to inhibit the cellular reuptake of glucose...
October 1993: Circulatory Shock
https://read.qxmd.com/read/8176421/lateral-suppression-and-inhibition-in-the-cochlear-nucleus-of-the-cat
#32
JOURNAL ARTICLE
W S Rhode, S Greenberg
1. The ability of cells in the cochlear nucleus (CN) to encode frequency information in the presence of background noise on the basis of "place/rate" information was investigated by measuring the threshold, magnitude, and extent of lateral suppression in the ventral and dorsal CN of the anesthesized cat. The suppression regions were delineated through the use of "masked" response areas (MRAs). The MRA is a family of isointensity curves derived from the average discharge rate in response to a tone of variable frequency and sound pressure level in the presence of a concurrently presented broadband, quasi-flat-spectrum noise...
February 1994: Journal of Neurophysiology
https://read.qxmd.com/read/8141346/autoregulation-of-cochlear-blood-flow-in-guinea-pigs
#33
JOURNAL ARTICLE
J N Brown, A L Nuttall
Autoregulation of blood flow in the inner ear following uncontrolled changes in systemic blood pressure (BP), which was induced by the application of pharmacological agents that cause local and/or systemic vascular effects, has been reported in previous studies. In the current study, carotid BP was systematically manipulated without drugs, while the resulting cochlear blood flow (CBF) changes were measured using a laser Doppler flowmeter (LDF). Anesthesized guinea pigs were used, and the probe of a LDF was held against the ventral-posterior portion of the surgically exposed cochlea...
February 1994: American Journal of Physiology
https://read.qxmd.com/read/8128338/a-tridimensional-study-using-cuts-at-a-low-temperature-of-the-infratemporal-region
#34
JOURNAL ARTICLE
C Madrid, D Lefebvre, L Gineste, D Duran, R Combelles, P Roux, R Joly, A Laveran
Although the infratemporal region is well defined anatomically, its complex topography has been the subject of numerous, and sometimes, opposite works. That is the reason why it appeared necessary for the authors to re-evaluate this topic using the original method of Combelles and Boyer, allowing to define three referential planes, and thereby, a tridimensional shape and the volume of this region. This study allows to conclude that the infratemporal region is a triangular prism with an horizontal main axis 47 mm long...
1993: Surgical and Radiologic Anatomy: SRA
https://read.qxmd.com/read/7914116/-the-effect-of-proxodolol-on-systemic-and-regional-hemodynamics
#35
COMPARATIVE STUDY
O V Dolgun, E R Martynova, O S Medvedev, S D Iuzhakov
The effect of the new hybrid (beta-, alpha-) adrenoceptor blocking drug proxodolol on cardiac output and its distribution between 16 vascular regions, by using the microsphere method on anesthesized normotensive rats and rats with persistent renovascular hypertension. Proxodolol given in beta-adreno-blocking doses similar to those of labetalol was shown to exert vasodilating effects in normotensive rats. Renal, adrenal, splenic, and skeletal muscle vessels were most sensitive to labetalol, whereas cardiac and pulmonary vessels were responsive to proxodolol...
May 1994: Eksperimental'naia i Klinicheskaia Farmakologiia
https://read.qxmd.com/read/7676722/-the-value-of-ckmb-and-myoglobin-determinations-during-reperfusion-after-regional-myocardial-ischemia-in-the-anesthesized-pig
#36
JOURNAL ARTICLE
J D Schipke, U Sunderdiek, J Scheja, W Bircks, G Arnold, M Kantartzis
The efficacy of a revascularization treatment after acute coronary artery occlusion can be evaluated by different diagnoses. The ECG and the time-course of, for example, the CK isoenzyme MB are widely used as quick, objective, and almost noninvasive tools. In addition, the assessment of functional recovery of the postischemic myocardium or the evaluation of the magnitude of irreversibly injured myocardium is essential for therapeutic strategies. In the present study, myoglobin that is not yet routinely established, is compared with CKMB to answer the following questions: do measurements of serum-CKMB and serum-myoglobin reliably demonstrate 1) the success of a revascularization treatment? 2) the functional recovery of the postischemic myocardium? 3) the magnitude of irreversibly injured myocardium? To answer these questions, the left anterior descending coronary arteries of 17 anesthetized pigs were occluded for 60 min and reperfused for 180 min after successful "revascularization"...
July 1995: Zeitschrift Für Kardiologie
https://read.qxmd.com/read/7663288/-the-effect-of-beta-adrenoblockaders-on-the-elasticity-of-the-vessels-of-the-greater-circulation
#37
COMPARATIVE STUDY
A V Syrenskiĭ, V A Tsyrlin
Experiments in anesthesized cats have shown that the two non-selective beta-adrenergic blocking drugs anapriline (propranolol) and tobanum (cloranolol hydrochloride) enhance vasodilation caused by increasing the blood flow volumetric velocity through the vascular region. It is suggested that the cause of increased vascular bed distensibility induced by these compounds is their capacity to release endothelium-relaxing factor. The cardiac selective beta-adrenoblocker metoprolol tartate had no effects on the regulation of vascular tone...
May 1995: Eksperimental'naia i Klinicheskaia Farmakologiia
https://read.qxmd.com/read/7531519/-effect-of-arginine-dependent-nitric-oxide-synthesis-on-regional-perfusion-of-the-eye-in-the-anesthesized-dog
#38
JOURNAL ARTICLE
R M Vogel, M Sonntag, A Deussen
The changes of the retinal and uveal perfusion after inhibition of the arginine-dependent nitric oxide (NO) synthesis by systemic administration of NG-nitro-L-arginine methyl ester (L-NAME; 20 mg/kg bw i.v.) were studied in four anesthetized dogs using the tracer microsphere technique. The regional perfusion rates (ml.min-1.g-1) under steady-state control conditions were: retina 0.13 +/- 0.05, choroid 8.26 +/- 1.85, iris 0.24 +/- 0.05 and ciliary body 1.11 +/- 0.26. Infusion of L-NAME over 10 min reduced the perfusion of the retina on the average by 23% (P > 0...
December 1994: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://read.qxmd.com/read/7421490/-loco-regional-anesthesia-in-remote-medical-units-vi-anesthesia-of-lower-abdomen-and-lower-limbs-peridural-anesthesia-author-s-transl
#39
JOURNAL ARTICLE
M Allemand, J Le Camus, Y Martin, M Vincent, L Cornen
Peridural anesthesia consists in impregnating by an anesthesic solution, through a lumbal puncture, the nervous radices at their emergence out of the dura mater. The authors detail the technique and its mishaps and accidents, the indications and counter-indications.
July 1980: Médecine Tropicale: Revue du Corps de Santé Colonial
https://read.qxmd.com/read/7366370/-loco-regional-anesthesia-in-remote-medical-units-iv-intercostal-block-author-s-transl
#40
JOURNAL ARTICLE
M Allemand, Y Martin, J Le Camus, M Vincent, L Cornen
The anesthesic fluid is injected close to the intercostal nerve at the starting point of its course in the corresponding space. Its gives an easy analgesia for thoracic or upper abdominal areas.
January 1980: Médecine Tropicale: Revue du Corps de Santé Colonial
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