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https://www.readbyqxmd.com/read/29089262/discovery-of-novel-nitroimidazole-enols-as-pseudomonas-aeruginosa-dna-cleavage-agents
#1
Zhen-Zhen Li, Lavanya Gopala, Vijai Kumar Reddy Tangadanchu, Wei-Wei Gao, Cheng-He Zhou
A series of nitroimidazole enols as new bacterial DNA-targeting agents were for the first time designed, synthesized and characterized by NMR, IR and HRMS spectra. The antimicrobial screening revealed that 2-methoxyphenyl nitroimidazole enol 3i possessed stronger anti-P. aeruginosa efficacy (MIC = 0.10 μmol/mL) than reference drugs Norfloxacin and Metronidazole. Time-kill kinetic assay manifested that the active molecule 3i could rapidly kill the tested strains. Molecular docking indicated that the interactions between compound 3i and topoisomerase II were driven by hydrogen bonds...
October 25, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29075355/design-synthesis-and-characterization-of-2-2-bis-2-4-dinitrophenyl-2-phosphonatomethylamino-acetate-as-a-herbicidal-and-biological-active-agent
#2
Vijay Kumar, Simranjeet Singh, Rohit Singh, Niraj Upadhyay, Joginder Singh
The present study was designed to synthesize the bioactive molecule 2,2-bis(2,4-dinitrophenyl)-2-(phosphonatomethylamino)acetate (1), having excellent applications in the field of plant protection as a herbicide. Structure of newly synthesized molecule 1 was confirmed by using the elemental analysis, mass spectrometric, NMR, UV-visible, and FTIR spectroscopic techniques. To obtain better structural insights of molecule 1, 3D molecular modeling was performed using the GAMESS programme. Microbial activities of 1 were checked against the pathogenic strains Aspergillus fumigatus (NCIM 902) and Salmonella typhimurium (NCIM 2501)...
October 2017: Journal of Chemical Biology
https://www.readbyqxmd.com/read/29055982/vitamin-a-status-and-its-determinants-in-patients-with-cystic-fibrosis
#3
Ewa Sapiejka, Patrycja Krzyżanowska, Dariusz Walkowiak, Ewa Wenska-Chyży, Mariusz Szczepanik, Szczepan Cofta, Andrzej Pogorzelski, Wojciech Skorupa, Jarosław Walkowiak
BACKGROUND: Routine administration of vitamin A, recommended in CF patients, can help to prevent its deficiency. However, high vitamin A supplementation may lead to its excessive level and possible toxicity. Therefore, the aim of the present study was to assess the status of vitamin A and the determinants of its body resources in CF patients. METHODS: In 196 CF patients aged from 4 months to 47 years, the following parameters  were analysed: nutritional status (standardized body weight and height, serum albumin concentration) and clinical expression of disease (lung function - spirometry; biochemical markers of liver function - ALT, AST, GGT; respiratory tract colonization by Pseudomonas aeruginosa; diabetes; cirrhosis, non-cirrhotic liver disease; exocrine pancreatic function - fecal elastase-1 concentration; blood clotting -  INR  and  vitamin  A supplementation)...
July 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28938203/green-synthesis-biological-and-spectroscopic-study-on-the-interaction-of-multi-component-mannich-bases-of-imidazo-2-1-b-benzothiazoles-with-human-serum-albumin
#4
Swetha K Maddili, Leela Prasad Yandrati, Shakuntala Siddam, Vijaya Kumar Kannekanti, Himabindu Gandham
A series of Mannich bases of imidazo[2, l-b]benzothiazoles were prepared through one-pot multi-component reaction in the presence of water as an eco-friendly solvent. All the synthesized compounds were confirmed from IR, (1)HNMR, (13)CNMR, and Mass spectroscopy. Evaluation of in vitro anti-inflammatory and anti-microbial activities of all the synthesized derivatives was further accomplished. These results clearly displayed that compound 6d exhibited outstanding anti-inflammatory activity with a percentage inhibition of 70...
November 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28860766/synthesized-zinc-peroxide-nanoparticles-zno2-nps-a-novel-antimicrobial-anti-elastase-anti-keratinase-and-anti-inflammatory-approach-toward-polymicrobial-burn-wounds
#5
Sameh Samir Ali, Reda Morsy, Nessma Ahmed El-Zawawy, Mervat F Fareed, Mohamed Yaser Bedaiwy
Increasing of multidrug resistance (MDR) remains an intractable challenge for burn patients. Innovative nanomaterials are also in high demand for the development of new antimicrobial biomaterials that inevitably have opened new therapeutic horizons in medical approaches and lead to many efforts for synthesizing new metal oxide nanoparticles (NPs) for better control of the MDR associated with the polymicrobial burn wounds. Recently, it seems that metal oxides can truly be considered as highly efficient inorganic agents with antimicrobial properties...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28735760/first-characterization-of-immunogenic-conjugates-of-vi-negative-salmonella-typhi-o-specific-polysaccharides-with-repa-protein-for-vaccine-development
#6
M Salman, F St Michael, A Ali, A Jabbar, C Cairns, A C Hayes, M Rahman, M Iqbal, A Haque, A D Cox
Efficacious typhoid vaccines for young children will significantly reduce the disease burden in developing world. The Vi polysaccharide based conjugate vaccines (Vi-rEPA) against Salmonella Typhi Vi positive strains has shown high efficacy but may be ineffective against Vi negative S. Typhi. In this study, for the first time, we report the synthesis and evaluation of polysaccharide-protein conjugates of Vi negative S. Typhi as potential vaccine candidates. Four different conjugates were synthesized using recombinant exoprotein A of Pseudomonas aeruginosa (rEPA) and human serum albumin (HSA) as the carrier proteins, using either direct reductive amination or an intermediate linker molecule, adipic acid dihydrazide (ADH)...
November 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28648453/tolerance-of-pseudomonas-aeruginosa-in-in-vitro-biofilms-to-high-level-peracetic-acid-disinfection
#7
A B Akinbobola, L Sherry, W G Mckay, G Ramage, C Williams
BACKGROUND: Biofilm has been suggested as a cause of disinfection failures in flexible endoscopes where no lapses in the decontamination procedure can be identified. To test this theory, the activity of peracetic acid, one of the widely used disinfectants in the reprocessing of flexible endoscopes, was evaluated against both planktonic and sessile communities of Pseudomonas aeruginosa. AIM: To investigate the ability of P. aeruginosa biofilm to survive high-level peracetic acid disinfection...
June 23, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28630071/albumin-inhibits-pseudomonas-aeruginosa-quorum-sensing-and-alters-polymicrobial-interactions
#8
Allie Clinton Smith, Anne Rice, Bryan Sutton, Rebecca Gabrilska, Aimee K Wessel, Marvin Whiteley, Kendra P Rumbaugh
Polymicrobial interactions are complex and can influence the course of an infection, as is the case when two or more species exhibit a synergism that produces a disease state not seen with any of the individual species alone. Cell-to-cell signaling is key to many of these interactions, but little is understood about how the host environment influences polymicrobial interactions or signaling between bacteria. Chronic wounds are typically polymicrobial, with Staphylococcus aureus and Pseudomonas aeruginosa being the two most commonly isolated species...
September 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28595608/antimicrobial-activity-toxicity-and-anti-inflammatory-potential-of-methanolic-extracts-of-four-ethnomedicinal-plant-species-from-punjab-pakistan
#9
Rabia Naz, Hafsa Ayub, Sajid Nawaz, Zia Ul Islam, Tayyaba Yasmin, Asghari Bano, Abdul Wakeel, Saqib Zia, Thomas H Roberts
BACKGROUND: The plant species Aristolochia indica (AI), Melilotus indicus (MI), Tribulus terrestris (TT) and Cuscuta pedicellata (CP) are widely used in folk medicine in the villages around Chowk Azam, South Punjab, Pakistan. The aim of this study was to evaluate the antioxidant activity, phytochemical composition, and the antibacterial, antifungal, cytotoxic and anti-inflammatory potential of the four medicinal plants listed above. For CP stem, this study represents (to the best of our knowledge) the first time phytochemicals have been identified and the antioxidant and anti-inflammatory potential determined...
June 8, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28448954/copper-complexes-containing-thiosemicarbazones-derived-from-6-nitropiperonal-antimicrobial-and-biophysical-properties
#10
Floyd A Beckford, Kelsey R Webb
A series of four thiosemicarbazones from 6-nitropiperonal along with the corresponding copper complexes were synthesized. The biophysical characteristics of the complexes were investigated by the binding to DNA and human serum albumin. The binding to DNA is moderate; the binding constants run from (0.49-7.50)×10(4)M(-1). In relation to HSA, the complexes interact strongly with binding constants on the order of 10(5)M(-1). The complexes also display antioxidant behavior as determined by the ability to scavenge diphenylpicrylhydrazyl (dpph) and nitric oxide radicals...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28289362/study-on-biofilm-formation-in-burn-wound-infection-in-a-pediatric-hospital-in-chennai-india
#11
M Ramakrishnan, S Putli Bai, M Babu
Infection is one of the major causes of death in pediatric burns in India. This work was conducted in an exclusive Children's Hospital (KKCTH) with a total of 220 beds, of which ten beds in the burn unit and two isolation beds in the 28-bed PICU are for burns patients (more than 20% TBSA burns) with sepsis. In this study, 30 burn wound swab isolates obtained from 14 pediatric burns patients (admitted to the burns ward and transferred to PICU) from November 2013 to March 2014 were investigated. Cultures were done on the first day for all patients and empirical antibiotic administration was started for those with septic burns (14 in total) with piperacillin-tazobactam and vancomycin...
December 31, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28155216/evaluation-of-the-role-of-substrate-and-albumin-on-pseudomonas-aeruginosa-biofilm-morphology-through-fesem-and-ftir-studies-on-polymeric-biomaterials
#12
S Dutta Sinha, Susmita Chatterjee, P K Maiti, S Tarafdar, S P Moulik
Bacterial biofilms pose the greatest challenge to implant surgeries leading to device-related infections and implant failure. Our present study aims at monitoring the variation in the biofilm architecture of a clinically isolated strain and ATCC 27853 strain of Pseudomonas aeruginosa on two polymeric biomaterials, used in implants. The perspective of our study is to recognize the potential of these two biomaterials to create biofilm infections and develop the understanding regarding their limitations of use and handle patients with this deeper insight...
May 2017: Progress in biomaterials
https://www.readbyqxmd.com/read/27932683/survival-of-bacteria-of-laboratory-animal-origin-on-cage-bedding-and-inactivation-by-hydrogen-peroxide-vapour
#13
Laurentiu Benga, W Peter M Benten, Eva Engelhardt, Christina Gougoula, Roland Schulze-Röbbecke, Martin Sager
This study aims to determine the ability of laboratory animal bacteria to resist desiccation and inactivation by hydrogen peroxide vapour (HPV) on paper bedding pieces. Bedding pieces were saturated with bacterial suspensions in water or 2% (w/v) bovine serum albumin (BSA) in water, and held in a mouse facility. Viable counts showed variable survival rates over time for the bacterial species used ([Pasteurella] pneumotropica, Muribacter muris, Pseudomonas aeruginosa, Acinetobacter redioresistens, Escherichia coli, Klebsiella oxytoca, Bordetella bronchiseptica, Bordetella hinzii, Enterococcus faecalis, β-haemolytic Streptococcus spp...
December 8, 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27796875/molecular-and-spectroscopic-characterization-of-aspergillus-flavipes-and-pseudomonas-putida-l-methionine-%C3%AE-lyase-in-vitro
#14
Ashraf S A El-Sayed, Laura E Ruff, Salah E Abdel Ghany, Gul Shad Ali, Sadik Esener
Pseudomonas putida L-methionine γ-lyase (PpMGL) has been recognized as an efficient anticancer agent, however, its antigenicity and stability remain as critical challenges for its clinical use. From our studies, Aspergillus flavipes L-methionine γ-lyase (AfMGL) displayed more affordable biochemical properties than PpMGL. Thus, the objective of this work was to comparatively assess the functional properties of AfMGL and PpMGL via stability of their internal aldimine linkage, tautomerism of pyridoxal 5'-phosphate (PLP) and structural stability responsive to physicochemical factors...
April 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27711156/in-vitro-antibacterial-activity-of-rhodanine-derivatives-against-pathogenic-clinical-isolates
#15
Ahmed AbdelKhalek, Charles R Ashby, Bhargav A Patel, Tanaji T Talele, Mohamed N Seleem
Bacterial infections present a serious challenge to healthcare practitioners due to the emergence of resistance to numerous conventional antibacterial drugs. Therefore, new bacterial targets and new antimicrobials are unmet medical needs. Rhodanine derivatives have been shown to possess potent antimicrobial activity via a novel mechanism. However, their potential use as antibacterials has not been fully examined. In this study, we determined the spectrum of activity of seven rhodanine derivatives (compounds Rh 1-7) against clinical isolates of Gram-positive and Gram-negative bacterial strains and Candida albicans...
2016: PloS One
https://www.readbyqxmd.com/read/27680092/a-2s-albumin-from-the-seed-cake-of-ricinus-communis-inhibits-trypsin-and-has-strong-antibacterial-activity-against-human-pathogenic-bacteria
#16
Pedro F N Souza, Ilka M Vasconcelos, Fredy D A Silva, Frederico B Moreno, Ana C O Monteiro-Moreira, Luciana M R Alencar, Angélica S G Abreu, Jeanlex S Sousa, José T A Oliveira
Hospital-acquired infections caused by antibiotic-resistant bacteria threaten the lives of many citizens all over the world. Discovery of new agents to hinder bacterial development would have a significant impact on the treatment of infections. Here, the purification and characterization of Rc-2S-Alb, a protein that belongs to the 2S albumin family, from Ricinus communis seed cake, are reported. Rc-2S-Alb was purified after protein extraction with Tris-HCl buffer, pH 7.5, fractionation by ammonium sulfate (50-75%), and chromatography on Phenyl-Sepharose and DEAE-Sepharose...
October 28, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27581112/treatment-failure-and-leg-amputation-among-patients-with-foot-osteomyelitis
#17
Neal R Barshes, Cezarina Mindru, Chester Ashong, Maria Rodriguez-Barradas, Barbara W Trautner
We sought to identify factors associated with treatment failure and leg amputations among those patients who presented with foot osteomyelitis. Characteristics, treatments, and outcomes for all patients treated for probable or definite foot osteomyelitis (per consensus definition) between January 2011 and March 2015 were reviewed. Multivariate Cox regression models were used to identify risk factors for treatment failure (unanticipated resection of additional bone or leg amputation) and of leg amputation alone...
December 2016: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/27573289/influence-of-molecular-design-on-biodistribution-and-targeting-properties-of-an-affibody-fused-her2-recognising-anticancer-toxin
#18
Mohamed Altai, Hao Liu, Anna Orlova, Vladimir Tolmachev, Torbjörn Gräslund
Targeted delivery of toxins is a promising way to treat disseminated cancer. The use of monoclonal antibodies as targeting moiety has provided proof-of-principle for this approach. However, extravasation and tissue penetration rates of antibody-based immunotoxins are limited due to antibody bulkiness. The use of a novel class of targeting probes, Affibody molecules, provides smaller toxin-conjugated constructs, which may improve targeting. Earlier, we have demonstrated that affitoxins containing a HER2-targeting Affibody moiety and a deimmunized and truncated exotoxin A from Pseudomonas aeruginosa, PE38X8, provide highly selective toxicity to HER2-expressing cancer cells...
September 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27426954/characterization-of-aerobic-oil-and-grease-degrading-bacteria-in-wastewater
#19
Alexis Nzila, Assad Thukair, Saravanan Sankara, Shaikh Abdur Razzak
A bacterial consortium that degrades cooking oil (CO) has been isolated in wastewater (WW) samples, by enrichment in olive CO. This consortium could degrade 90% of CO within 7-9 days (from an initial 1% [w/v]), and it is more active at alkaline conditions. The 16S ribonucleic acid (RNA) gene analysis showed that it contains five bacterium species: Stenotrophomonas rhizophila, Sphingobacterium sp., Pseudomonas libanensis, Pseudomonas poae and Pseudomonas aeruginosa. This consortium can degrade the free fatty acids (FFA): palmitic, stearic, oleic, linoleic and linolenic acids; glycerol, glucose and amylose; and albumin, but could not efficiently degrade carboxymethyl-cellulose...
March 2017: Environmental Technology
https://www.readbyqxmd.com/read/27381280/bioactive-and-biocompatible-copper-containing-glass-ceramics-with-remarkable-antibacterial-properties-and-high-cell-viability-designed-for-future-in-vivo-trials
#20
R A Popescu, K Magyari, A Vulpoi, D L Trandafir, E Licarete, M Todea, R Ştefan, C Voica, D C Vodnar, S Simon, I Papuc, L Baia
In the present study our interest is focused on finding the efficiency of 60SiO2·(32 - x)CaO·8P2O5·xCuO (mol%) glass-ceramics, with 0 ≤ x ≤ 4 mol%, in terms of bioactivity, biocompatibility, antibacterial properties and cell viability in order to determine the most appropriate composition for their further use in in vivo trials. The sol-gel synthesized samples show a preponderantly amorphous structure with a few crystallization centers associated with the formation of an apatite and calcium carbonate crystalline phases...
July 19, 2016: Biomaterials Science
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