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Dissociative Symptoms

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https://www.readbyqxmd.com/read/29343286/diagnosis-and-management-of-transthyretin-familial-amyloid-polyneuropathy-in-japan-red-flag-symptom-clusters-and-treatment-algorithm
#1
REVIEW
Yoshiki Sekijima, Mitsuharu Ueda, Haruki Koike, Sonoko Misawa, Tomonori Ishii, Yukio Ando
Hereditary ATTR (ATTRm) amyloidosis (also called transthyretin-type familial amyloid polyneuropathy [ATTR-FAP]) is an autosomal-dominant, adult-onset, rare systemic disorder predominantly characterized by irreversible, progressive, and persistent peripheral nerve damage. TTR gene mutations (e.g. replacement of valine with methionine at position 30 [Val30Met (p.Val50Met)]) lead to destabilization and dissociation of TTR tetramers into variant TTR monomers, which form amyloid fibrils that deposit in peripheral nerves and various organs, giving rise to peripheral and autonomic neuropathy and several non-disease specific symptoms...
January 17, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29339294/ketamine-for-the-treatment-of-addiction-evidence-and-potential-mechanisms
#2
REVIEW
I Ivan Ezquerra-Romano, W Lawn, E Krupitsky, C J A Morgan
Ketamine is a dissociative anaesthetic drug which acts on the central nervous system chiefly through antagonism of the n-methyl-d-aspartate (NMDA) receptor. Recently, ketamine has attracted attention as a rapid-acting anti-depressant but other studies have also reported its efficacy in reducing problematic alcohol and drug use. This review explores the preclinical and clinical research into ketamine's ability to treat addiction. Despite methodological limitations and the relative infancy of the field, results thus far are promising...
January 12, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29323257/dengue-virus-induced-er-stress-is-required-for-autophagy-activation-viral-replication-and-pathogenesis-both-in-vitro-and-in-vivo
#3
Ying-Ray Lee, Szu-Han Kuo, Ching-Yen Lin, Po-Jung Fu, Yee-Shin Lin, Trai-Ming Yeh, Hsiao-Sheng Liu
Dengue virus (DENV) utilizes the endoplasmic reticulum (ER) for replication and assembling. Accumulation of unfolded proteins in the ER lumen leads to ER stress and unfolded protein response (UPR). Three branches of UPRs temporally modulated DENV infection. Moreover, ER stress can also induce autophagy. DENV infection induces autophagy which plays a promotive role in viral replication has been reported. However, the role of ER stress in DENV-induced autophagy, viral titer, and pathogenesis remain unclear. Here, we reveal that ER stress and its downstream UPRs are indispensable for DENV-induced autophagy in various human cells...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321658/slower-time-estimation-in-post-traumatic-stress-disorder
#4
Carmelo M Vicario, Kim L Felmingham
Cognitive deficits in Posttraumatic Stress Disorder (PTSD) and dissociative symptoms suggest there may be an underlying and persistent problem with temporal processing in PTSD, but this question has not been systematically examined. We investigated the ability of a group of PTSD participants in estimating the duration of supra-second visual stimuli relative to healthy controls. The data of 59 participants with PTSD and 62 healthy controls, collected from the BRID database, have been examined. Overall, our results indicate that PTSD patients overestimate the duration of the displayed stimuli...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317663/trpv1-enhances-the-afferent-response-to-p2x-receptor-activation-in-the-mouse-urinary-bladder
#5
Luke Grundy, Donna M Daly, Christopher Chapple, David Grundy, Russ Chess-Williams
Both TRPV1 and P2X receptors present on bladder sensory nerve fibres have been implicated in mechanosensation during bladder filling. The aim of this study was to determine possible interactions between these receptors in modulating afferent nerve activity. In wildtype (TRPV1+/+) and TRPV1 knockout (TRPV1-/-) mice, bladder afferent nerve activity, intravesical pressure, and luminal ATP and acetylcholine levels were determined and also intracellular calcium responses of dissociated pelvic DRG neurones and primary mouse urothelial cells (PMUCs)...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29315737/the-dissociative-post-traumatic-stress-disorder-ptsd-subtype-a-treatment-outcome-cohort-study-in-veterans-with-ptsd
#6
Joris F G Haagen, Allison van Rijn, Jeroen W Knipscheer, Niels van der Aa, Rolf J Kleber
OBJECTIVES: Dissociation is a prevalent phenomenon among veterans with post-traumatic stress disorder (PTSD) that may interfere with the effectiveness of treatment. This study aimed to replicate findings of a dissociative PTSD subtype, to identify corresponding patterns in coping style, symptom type, and symptom severity, and to investigate its impact on post-traumatic symptom improvement. METHODS: Latent profile analysis (LPA) was applied to baseline data from 330 predominantly (97%) male treatment-seeking veterans (mean age 39...
January 7, 2018: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29314030/residues-in-the-analyst-of-the-patient-s-symbiotic-connection-at-a-somatic-level-unrepresented-states-in-the-patient-and-analyst
#7
Geraldine Godsil
This paper discusses the residues of a somatic countertransference that revealed its meaning several years after apparently successful analytic work had ended. Psychoanalytic and Jungian analytic ideas on primitive communication, dissociation and enactment are explored in the working through of a shared respiratory symptom between patient and analyst. Growth in the analyst was necessary so that the patient's communication at a somatic level could be understood. Bleger's concept that both the patient's and analyst's body are part of the setting was central in the working through...
February 2018: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/29302772/development-and-preliminary-psychometric-properties-of-an-instrument-for-the-measurement-of-obsessional-dissociative-experiences-the-van-obsessional-dissociation-questionnaire-vod-q
#8
Murat Boysan, Abdullah Yıldırım, Lütfullah Beşiroğlu, Mehmet Celal Kefeli, Mücahit Kağan
A growing body of research evidence documents the substantial associations between obsessive-compulsive disorder (OCD) and dissociation. This article describes the development and preliminary psychometric properties of the Van Obsessional Dissociation Questionnaire (VOD-Q). Obsessional dissociation is defined as a tendency to dissociate in reaction to distressing, unwanted and intrusive thoughts, images and impulses. The screening tool is conceptualized to tap obsessional dissociation across three dimensions: obsessional absorption, obsessional depersonalization/ derealization and obsessional amnesia...
January 4, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29296086/brain-functional-integration-an-epidemiologic-study-on-stress-producing-dissociative-phenomena
#9
Raffaele Sperandeo, Vincenzo Monda, Giovanni Messina, Marco Carotenuto, Nelson Mauro Maldonato, Enrico Moretto, Elena Leone, Vincenzo De Luca, Marcellino Monda, Antonietta Messina
Dissociative phenomena are common among psychiatric patients; the presence of these symptoms can worsen the prognosis, increasing the severity of their clinical conditions and exposing them to increased risk of suicidal behavior. Personality disorders as long duration stressful experiences may support the development of dissociative phenomena. In 933 psychiatric outpatients consecutively recruited, presence of dissociative phenomena was identified with the Dissociative Experience Scale (DES). Dissociative phenomena were significantly more severe in the group of people with mental disorders and/or personality disorders...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29295027/intimate-partner-violence-among-patients-with-dissociative-disorders
#10
Aliya R Webermann, Bethany L Brand, Shaina A Kumar
Childhood trauma is common among survivors and perpetrators of intimate partner violence (IPV). Although symptoms of posttraumatic stress disorder (PTSD) and dissociative disorders (DDs) are predictors of IPV victimization and perpetration, few studies explore IPV among those with DDs. The present study examined IPV and symptoms as predictors among participants in the Treatment of Patients With Dissociative Disorders (TOP DD) Network study, an educational intervention for individuals with DDs and their clinicians...
December 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294822/mediators-of-the-relationship-between-sexual-assault-and-sexual-behaviors-in-college-women
#11
Erika L Kelley, Christine A Gidycz
Some research shows that sexual assault victimization is associated with increased engagement in risky sexual behavior (e.g., intercourse without use of a condom or contraceptives), whereas other research indicates sexual assault victimization is related to sexual aversion. The purpose of the current study was to examine whether posttraumatic stress symptoms, alcohol use, and sexual assertiveness mediated the relationship between adolescent/emerging adulthood sexual assault (ASA) and risky sexual behavior, and whether posttraumatic stress symptoms mediated the relationship between ASA and sexual aversion, among college women...
July 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294725/association-of-domestic-violence-against-women-with-sociodemographic-factors-clinical-features-and-dissociative-symptoms-in-patients-who-receive-services-from-psychiatric-outpatient-units-in-turkey
#12
Zeynep Kotan, Vahap Ozan Kotan, Hayriye Dilek Yalvaç, Sibel Demir
Domestic violence (DV) against women is a serious problem with its negative effects on all family members and the society. Women exposed to DV not only have physical but also psychological damage. This study investigates prevalence of DV and its relations with some descriptive and clinical features in a psychiatric outpatient population in Turkey. A total of 277 female outpatients were included in the study. After a semistructured clinical interview, they were assessed by sociodemographic data form, DV questionnaire, Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), Dissociative Experiences Scale (DES), and Somatoform Dissociation Questionnaire (SDQ)...
April 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294684/the-mediating-roles-of-hostility-and-dissociation-in-the-relationship-between-sexual-assault-and-suicidal-thinking-in-college-students
#13
Kristy M Keefe, Melanie D Hetzel-Riggin, Naoyuki Sunami
Sexual assault and suicide are two serious public health concerns. Research has documented the relationship between sexual assault and suicidal thinking and attempts; however, limited research explores the more multifaceted relationships between posttraumatic stress reactions and suicidal ideation in college students through unsuccessful modulation of emotion. The authors hypothesized a mediation model where the relationship between sexual assault and suicidal ideation is mediated by dissociation and hostility...
March 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294663/gender-differences-in-the-prediction-of-acute-stress-disorder-from-peritraumatic-dissociation-and-distress-among-victims-of-violent-crimes
#14
Julie Boisclair Demarble, Christophe Fortin, Bianca D'Antono, Stéphane Guay
Peritraumatic dissociation and distress are strong predictors of acute stress disorder (ASD) and posttraumatic stress disorder (PTSD) development. However, there is limited data concerning gender differences in these relations, particularly among victims of violent crimes (VVC). The objective of this study is to examine whether peritraumatic dissociation and distress predict the number of ASD symptoms differently for men and women VVC. In all, 162 adults (97 women, M age = 39.6 years), 63% of whom experienced physical assaults, completed the Acute Stress Disorder Interview, the Peritraumatic Dissociative Experience Questionnaire, and the Peritraumatic Distress Inventory...
February 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29285732/emerging-approaches-to-neurocircuits-in-ptsd-and-tbi-imaging-the-interplay-of-neural-and-emotional-trauma
#15
Andrea D Spadoni, Mingxiong Huang, Alan N Simmons
Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) commonly co-occur in general and military populations and have a number of overlapping symptoms. While research suggests that TBI is risk factor for PTSD and that PTSD may mediate TBI-related outcomes, the mechanisms of these relationships are not well understood. Neuroimaging may help elucidate patterns of neurocircuitry both specific and common to PTSD and TBI and thus help define the nature of their interaction, refine diagnostic classification, and may potentially yield opportunities for targeted treatments...
December 29, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/29282709/neurodevelopmental-origins-of-abnormal-cortical-morphology-in-dissociative-identity-disorder
#16
A A T S Reinders, S Chalavi, Y R Schlumpf, E M Vissia, E R S Nijenhuis, L Jäncke, D J Veltman, C Ecker
OBJECTIVE: To examine the two constitutes of cortical volume (CV), that is, cortical thickness (CT) and surface area (SA), in individuals with dissociative identity disorder (DID) with the view of gaining important novel insights into the underlying neurobiological mechanisms mediating DID. METHODS: This study included 32 female patients with DID and 43 matched healthy controls. Between-group differences in CV, thickness, and SA, the degree of spatial overlap between differences in CT and SA, and their relative contribution to differences in regional CV were assessed using a novel spatially unbiased vertex-wise approach...
December 27, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29282469/efficacy-and-safety-of-intranasal-esketamine-adjunctive-to-oral-antidepressant-therapy-in-treatment-resistant-depression-a-randomized-clinical-trial
#17
Ella J Daly, Jaskaran B Singh, Maggie Fedgchin, Kimberly Cooper, Pilar Lim, Richard C Shelton, Michael E Thase, Andrew Winokur, Luc Van Nueten, Husseini Manji, Wayne C Drevets
Importance: Approximately one-third of patients with major depressive disorder (MDD) do not respond to available antidepressants. Objective: To assess the efficacy, safety, and dose-response of intranasal esketamine hydrochloride in patients with treatment-resistant depression (TRD). Design, Setting, and Participants: This phase 2, double-blind, doubly randomized, delayed-start, placebo-controlled study was conducted in multiple outpatient referral centers from January 28, 2014, to September 25, 2015...
December 27, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29276971/child-abuse-and-neglect-in-institutional-settings-cumulative-lifetime-traumatization-and-psychopathological-long-term-correlates-in-adult-survivors-the-vienna-institutional-abuse-study
#18
Brigitte Lueger-Schuster, Matthias Knefel, Tobias M Glück, Reinhold Jagsch, Viktoria Kantor, Dina Weindl
Child maltreatment (CM) in foster care settings (i.e., institutional abuse, IA) is known to have negative effects on adult survivor's mental health. This study examines and compares the extent of CM (physical, emotional, and sexual abuse; physical and emotional neglect) and lifetime traumatization with regard to current adult mental health in a group of survivors of IA and a comparison group from the community. Participants in the foster care group (n = 220) were adult survivors of IA in Viennese foster care institutions, the comparison group (n = 234) consisted of persons from the Viennese population...
December 22, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29262477/-clinical-analysis-of-four-cases-of-anti-gq1b-syndrome
#19
X Y Yang, T L Han, W H Zhang, S Zhang, F Fang
Objective: To investigate the clinical manifestations, laboratory findings, treatment and outcome of anti-GQ1b antibody syndrome. Method: The clinical manifestations, laboratory examination, diagnosis, treatment and prognosis of (4 patients 4 male patients, from 4 to 12 years) with anti-GQ1b syndrome in Beijing Children's Hospital affiliated to Capital Medical University from 2015 to 2016 were retrospectively analyzed. Result: All 4 children presented with ataxia. Case 1 showed impaired speech, ptosis and weakness of arms; case 2 and 3 had external ophthalmoplegia, weakness of limbs; case 4 presented hypersomnia, irritability and hallucinations...
December 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29258561/a-pilot-investigation-on-dna-methylation-modifications-associated-with-complex-posttraumatic-symptoms-in-elderly-traumatized-in-childhood
#20
Zoya Marinova, Andreas Maercker, Edna Grünblatt, Tomasz K Wojdacz, Susanne Walitza
OBJECTIVE: Complex posttraumatic stress disorder (CPTSD) is a newly proposed diagnosis in the International Classification of Diseases-version 11, which is currently intensively investigated. Childhood trauma is regarded as main source of CPTSD symptoms, even in later life. Induction of DNA methylation changes by childhood trauma may contribute to its long-lasting adverse health consequences. The current study analyzed the correlation of genome-wide DNA methylation profiles with complex posttraumatic sequelae in buccal epithelial cells from 31 elderly former indentured child laborers (Verdingkinder) using the Infinium Illumina 450k Human DNA methylation chip...
December 19, 2017: BMC Research Notes
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