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Dissociative Symptoms

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https://www.readbyqxmd.com/read/27906103/progressive-impairment-of-cav1-1-function-in-the-skeletal-muscle-of-mice-expressing-a-mutant-type-1-cu-zn-superoxide-dismutase-g93a-linked-to-amyotrophic-lateral-sclerosis
#1
Donald Beqollari, Christin F Romberg, Gabriella Dobrowolny, Martina Martini, Andrew A Voss, Antonio Musarò, Roger A Bannister
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder that is typically fatal within 3-5 years of diagnosis. While motoneuron death is the defining characteristic of ALS, the events that underlie its pathology are not restricted to the nervous system. In this regard, ALS muscle atrophies and weakens significantly before presentation of neurological symptoms. Since the skeletal muscle L-type Ca(2+) channel (CaV1.1) is a key regulator of both mass and force, we investigated whether CaV1...
June 23, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27878907/from-childhood-trauma-to-self-harm-an-investigation-of-theoretical-pathways-among-female-prisoners
#2
Ruth Howard, Thanos Karatzias, Kevin Power, Adam Mahoney
BACKGROUND: Despite empirical evidence suggesting complex associations between childhood trauma and self-harm, there is a dearth of research investigating this association in the female prison population. The current study explored pathways to self-harm following childhood trauma, by investigating the mediating roles of Post-traumatic Stress Disorder (PTSD) symptoms, emotion regulation and dissociation, in this relationship, within a sample of 89 female prisoners. METHODS: Cross-sectional, interview-format, questionnaire study within a female prison population...
November 22, 2016: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/27876453/-i-can-t-tell-whether-it-s-my-hand-a-pilot-study-of-the-neurophenomenology-of-body-representation-during-the-rubber-hand-illusion-in-trauma-related-disorders
#3
Daniela Rabellino, Sherain Harricharan, Paul A Frewen, Dalila Burin, Margaret C McKinnon, Ruth A Lanius
BACKGROUND: Early traumatic experiences are thought to be causal factors in the development of trauma-related dissociative experiences, including depersonalization and derealization. The rubber hand illusion (RHI), a well-known paradigm that measures multi-sensorial integration of a rubber hand into one's own body representation, has been used to investigate alterations in the experience of body ownership and of body representation. Critically, however, it has never been studied in individuals with trauma-related disorders...
2016: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/27873541/the-relationship-between-suppression-and-subsequent-intrusions-the-mediating-role-of-peritraumatic-dissociation-and-anxiety
#4
Cornelia Măirean, Ciprian Marius Ceobanu
BACKGROUND AND OBJECTIVES: Although previous studies showed that thought and emotion suppression represent risk factors for intrusions development, the mechanisms that explain these relations were less explored. This study aims to examine the relationships between thought and emotion suppression and the symptoms of intrusion following the exposure to a trauma-related event. Moreover, we explored if these relationships would be mediated by peritraumatic state dissociation and state anxiety...
November 22, 2016: Anxiety, Stress, and Coping
https://www.readbyqxmd.com/read/27869465/association-of-peritraumatic-dissociation-with-symptoms-of-depression-and-posttraumatic-stress-disorder
#5
Erin C McCanlies, Khachatur Sarkisian, Michael E Andrew, Cecil M Burchfiel, John M Violanti
Aim: In this study, we evaluated whether peritraumatic dissociation (PD) was associated with symptoms of depression and posttraumatic stress disorder (PTSD), and whether this association was modified by trauma prior to police work. Method: Symptoms of depression, PTSD, peritraumatic dissociative experience (PDE), and trauma prior to police work were measured using the Center for Epidemiologic Studies Depression scale, PTSD Checklist-Civilian, PDE questionnaire, and the Brief Trauma questionnaire, respectively, in 328 police officers...
November 21, 2016: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/27865948/neuronal-fc-epsilon-receptor-i-contributes-to-antigen-evoked-pruritus-in-a-murine-model-of-ocular-allergy
#6
Fan Liu, Lubin Xu, Naze Chen, Mo Zhou, Chunyan Li, Qian Yang, Yikuan Xie, Yuguang Huang, Chao Ma
Pruritus is the major symptom of ocular allergy but currently available treatments are often ineffective. Previous studies demonstrated that subpopulations of primary sensory neurons express Fc receptors and may contribute to antigen-specific pain. We investigated the role of neuronal Fc-epsilon Receptor I (FcεRI) in allergic ocular pruritus. Ovalbumin (OVA) was used as allergen together with alum adjuvant (OVA+alum) to produce a mouse model of ocular allergy with a significant elevation in the serum levels of both antigen-specific IgE and IgG...
November 16, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27857960/heat-strain-during-military-training-activities-the-dilemma-of-balancing-force-protection-and-operational-capability
#7
Andrew P Hunt, Daniel C Billing, Mark J Patterson, Joanne N Caldwell
Military activities in hot environments pose 2 competing demands: the requirement to perform realistic training to develop operational capability with the necessity to protect armed forces personnel against heat-related illness. To ascertain whether work duration limits for protection against heat-related illness restrict military activities, this study examined the heat strain and risks of heat-related illness when conducting a military activity above the prescribed work duration limits. Thirty-seven soldiers conducted a march (10 km; ∼5...
April 2016: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/27854088/long-term-and-strong-immunotherapy-to-treat-anti-n-methyl-d-aspartate-receptor-encephalitis-with-refractory-status-epilepticus
#8
Lan-Hsin Lee, Chien-Jung Lu
BACKGROUND: Anti-N-Methyl-D-Aspartate receptor (anti-NMDAR) encephalitis is responsive to immunotherapy and removal of tumor, but there is no consensus in the treatment of severe anti- NMDAR encephalitis with prolonged refractory status epilepticus (SE). CASE REPORT: A 17-year-old girl presented as acute psychosis, refractory seizures, hyperkinesia, autonomic instability, and soon progressed to a dissociative state of coma. Anti-NMDAR antibodies were positive in serum and CSF...
September 15, 2016: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/27836200/ptsd-in-court-i-introducing-ptsd-for-court
#9
Gerald Young
The first part of the series of three articles on posttraumatic stress disorder (PTSD) in Court to appear in the journal reviews the history of the construct of PTSD and its presentation in the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition; American Psychiatric Association, 2013) and the ICD-11 (International Classification of Diseases, 11th Edition; World Health Organization, 2018). There are 20 symptoms of PTSD in the DSM-5. PTSD symptoms are arranged into a four-cluster model, which has received partial support in the literature...
November 8, 2016: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/27833939/probabilistic-reinforcement-learning-in-patients-with-schizophrenia-relationships-to-anhedonia-and-avolition
#10
Erin C Dowd, Michael J Frank, Anne Collins, James M Gold, Deanna M Barch
BACKGROUND: Anhedonia (a reduced experience of pleasure) and avolition (a reduction in goal-directed activity) are common features of schizophrenia that have substantial effects on functional outcome, but are poorly understood and treated. Here, we examined whether alterations in reinforcement learning may contribute to these symptoms in schizophrenia by impairing the translation of reward information into goal-directed action. METHODS: 38 stable outpatients with schizophrenia or schizoaffective disorder and 37 healthy controls underwent fMRI during a probabilistic stimulus selection reinforcement learning task with dissociated choice- and feedback-related activation, followed by a behavioral transfer task allowing separate assessment of learning from positive versus negative outcomes...
September 2016: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/27822679/a-review-of-hallucinogen-persisting-perception-disorder-hppd-and-an-exploratory-study-of-subjects-claiming-symptoms-of-hppd
#11
John H Halpern, Arturo G Lerner, Torsten Passie
Hallucinogen persisting perception disorder (HPPD) is rarely encountered in clinical settings. It is described as a re-experiencing of some perceptual distortions induced while intoxicated and suggested to subsequently cause functional impairment or anxiety. Two forms exist: Type 1, which are brief "flashbacks," and Type 2 claimed to be chronic, waxing, and waning over months to years. A review of HPPD is presented. In addition, data from a comprehensive survey of 20 subjects reporting Type-2 HPPD-like symptoms are presented and evaluated...
November 8, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27821089/posterior-reversible-encephalopathy-as-the-first-manifestation-of-bickerstaff-s-brainstem-encephalitis
#12
Pei-Ru Chen, Shih-Pin Chen
BACKGROUND: Posterior reversible encephalopathy syndrome (PRES) has been associated with Guillain-Barre syndrome in rare cases. Here we report a patient in whom PRES was the presenting manifestation of Bickerstaff's brainstem encephalitis. CASE PRESENTATION: A 75-year-old woman presented with acute onset of hypertension, headache, blurred vision, and left eyelid drooping. Magnetic resonance imaging of the brain showed characteristic PRES lesions involving the parietal and occipital lobes bilaterally...
November 8, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27799902/localization-of-impaired-kinesthetic-processing-post-stroke
#13
Jeffrey M Kenzie, Jennifer A Semrau, Sonja E Findlater, Amy Y Yu, Jamsheed A Desai, Troy M Herter, Michael D Hill, Stephen H Scott, Sean P Dukelow
Kinesthesia is our sense of limb motion, and allows us to gauge the speed, direction, and amplitude of our movements. Over half of stroke survivors have significant impairments in kinesthesia, which leads to greatly reduced recovery and function in everyday activities. Despite the high reported incidence of kinesthetic deficits after stroke, very little is known about how damage beyond just primary somatosensory areas affects kinesthesia. Stroke provides an ideal model to examine structure-function relationships specific to kinesthetic processing, by comparing lesion location with behavioral impairment...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27799774/impact-of-dissociation-on-treatment-of-depressive-and-anxiety-spectrum-disorders-with-and-without-personality-disorders
#14
Jan Prasko, Ales Grambal, Petra Kasalova, Dana Kamardova, Marie Ociskova, Michaela Holubova, Kristyna Vrbova, Zuzana Sigmundova, Klara Latalova, Milos Slepecky, Marta Zatkova
OBJECTIVE: The central goal of the study was to analyze the impact of dissociation on the treatment effectiveness in patients with anxiety/neurotic spectrum and depressive disorders with or without comorbid personality disorders. METHODS: The research sample consisted of inpatients who were hospitalized in the psychiatric department and met the ICD-10 criteria for diagnosis of depressive disorder, panic disorder, generalized anxiety disorder, mixed anxiety-depressive disorder, agoraphobia, social phobia, obsessive compulsive disorder, posttraumatic stress disorder, adjustment disorders, dissociative/conversion disorders, somatoform disorder, or other anxiety/neurotic spectrum disorder...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27797341/neuronal-firing-patterns-outweigh-circuitry-oscillations-in-parkinsonian-motor-control
#15
Ming-Kai Pan, Sheng-Han Kuo, Chun-Hwei Tai, Jyun-You Liou, Ju-Chun Pei, Chia-Yuan Chang, Yi-Mei Wang, Wen-Chuan Liu, Tien-Rei Wang, Wen-Sung Lai, Chung-Chin Kuo
Neuronal oscillations at beta frequencies (20-50 Hz) in the cortico-basal ganglia circuits have long been the leading theory for bradykinesia, the slow movements that are cardinal symptoms in Parkinson's disease (PD). The beta oscillation theory helped to drive a frequency-based design in the development of deep brain stimulation therapy for PD. However, in contrast to this theory, here we have found that bradykinesia can be completely dissociated from beta oscillations in rodent models. Instead, we observed that bradykinesia is causatively regulated by the burst-firing pattern of the subthalamic nucleus (STN) in a feed-forward, or efferent-only, mechanism...
December 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27788465/maladaptive-five-factor-model-personality-traits-associated-with-borderline-personality-disorder-indirectly-affect-susceptibility-to-suicide-ideation-through-increased-anxiety-sensitivity-cognitive-concerns
#16
Raymond P Tucker, Greg J Lengel, Caitlin E Smith, Dan W Capron, Stephanie N Mullins-Sweatt, LaRicka R Wingate
The current study investigated the relationship between maladaptive Five-Factor Model (FFM) personality traits, anxiety sensitivity cognitive concerns, and suicide ideation in a sample of 131 undergraduate students who were selected based on their scores on a screening questionnaire regarding Borderline Personality Disorder (BPD) symptoms. Those who endorsed elevated BPD symptoms in a pre-screen analyses completed at the beginning of each semester were oversampled in comparison to those with low or moderate symptoms...
September 3, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27778456/parinaud-syndrome-a-25-year-1991-2016-review-of-40-consecutive-adult-cases
#17
Melissa Shields, Swati Sinkar, WengOnn Chan, John Crompton
PURPOSE: To characterize the clinical features, aetiology and management of ophthalmic symptoms in adult patients with Parinaud syndrome. METHODS: This is a retrospective, non-comparative observational case series. We reviewed 40 consecutive charts of adult patients with the clinical diagnosis of Parinaud syndrome at the Royal Adelaide Hospital Department of Ophthalmology in Adelaide, South Australia, between 1991 and 2016. Charts were reviewed for the following: (1) demographic information, (2) clinical presentation, (3) neuro-ophthalmology signs, (4) aetiology of Parinaud syndrome, and (5) management...
October 24, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27778296/somatostatin-receptor-ligands-in-acromegaly-clinical-response-and-factors-predicting-resistance
#18
Rosa Maria Paragliola, Salvatore Maria Corsello, Roberto Salvatori
INTRODUCTION: Somatostatin (SST) receptor ligands (SRL), in particular those of first generation (Octreotide and Lanreotide), are widely used in medical treatment of acromegaly, but they assure biochemical control of disease (and the possibility of an improvement of clinical symptoms and tumor shrinkage), only in a subset of patients. DISCUSSION: The mechanisms underlying the so called "SRL resistance" are various and involve in particular SST receptor expression and molecular pathways of signal transduction...
October 24, 2016: Pituitary
https://www.readbyqxmd.com/read/27775492/dsm-5-turkish-validity-and-reliability-of-dissociative-symptoms-severity-scale-child-form
#19
Şermin Yalın Sapmaz, Dilek Ergin, Nesrin Şen Celasin, Handan Özek Erkuran, Duygu Karaarslan, Siğnem Öztekin, Bengisu Uzel Tanrıverdi, Ertuğrul Köroğlu, Ömer Aydemir
The goal of this study was to assess the validity and reliability of the Turkish version of the DSM-5 Dissociative Symptoms Severity Scale-Child Form. The scale was prepared by translating and then back translating the DSM-5 Dissociative Symptoms Severity Scale. The study groups included one group of 30 patients diagnosed with posttraumatic stress disorder who were treated in a child and adolescent psychiatry unit and a second group of 83 healthy volunteers from middle and high schools in the community. For assessment, the Adolescent Dissociative Experiences Scale (ADES) was used in addition to the DSM-5 Dissociative Symptoms Severity Scale...
October 24, 2016: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/27769568/specific-frontostriatal-circuits-for-impaired-cognitive-flexibility-and-goal-directed-planning-in-obsessive-compulsive-disorder-evidence-from-resting-state-functional-connectivity
#20
Matilde M Vaghi, Petra E Vértes, Manfred G Kitzbichler, Annemieke M Apergis-Schoute, Febe E van der Flier, Naomi A Fineberg, Akeem Sule, Rashid Zaman, Valerie Voon, Prantik Kundu, Edward T Bullmore, Trevor W Robbins
BACKGROUND: A recent hypothesis has suggested that core deficits in goal-directed behavior in obsessive-compulsive disorder (OCD) are caused by impaired frontostriatal function. We tested this hypothesis in OCD patients and control subjects by relating measures of goal-directed planning and cognitive flexibility to underlying resting-state functional connectivity. METHODS: Multiecho resting-state acquisition, combined with micromovement correction by blood oxygen level-dependent sensitive independent component analysis, was used to obtain in vivo measures of functional connectivity in 44 OCD patients and 43 healthy comparison subjects...
August 11, 2016: Biological Psychiatry
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