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Dissociative Symptoms

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https://www.readbyqxmd.com/read/28338967/thought-disorder-in-schizophrenia-and-bipolar-disorder-probands-their-relatives-and-nonpsychiatric-controls
#1
Charity J Morgan, Michael J Coleman, Ayse Ulgen, Lenore Boling, Jonathan O Cole, Frederick V Johnson, Jan Lerbinger, J Alexander Bodkin, Philip S Holzman, Deborah L Levy
Thought disorder (TD) has long been associated with schizophrenia (SZ) and is now widely recognized as a symptom of mania and other psychotic disorders as well. Previous studies have suggested that the TD found in the clinically unaffected relatives of SZ, schizoaffective and bipolar probands is qualitatively similar to that found in the probands themselves. Here, we examine which quantitative measures of TD optimize the distinction between patients with diagnoses of SZ and bipolar disorder with psychotic features (BP) from nonpsychiatric controls (NC) and from each other...
March 1, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28333525/a-potential-psychological-mechanism-linking-disaster-related-prenatal-maternal-stress-with-child-cognitive-and-motor-development-at-16-months-the-qf2011-queensland-flood-study
#2
Katrina M Moss, Gabrielle Simcock, Vanessa Cobham, Sue Kildea, Guillaume Elgbeili, David P Laplante, Suzanne King
Fetal exposure to prenatal maternal stress can have lifelong consequences, with different types of maternal stress associated with different areas of child development. Fewer studies have focused on motor skills, even though they are strongly predictive of later development across a range of domains. Research on mechanisms of transmission has identified biological cascades of stress reactions, yet links between psychological stress reactions are rarely studied. This study investigates the relationship between different aspects of disaster-related prenatal maternal stress and child cognitive and motor development, and proposes a cascade of stress reactions as a potential mechanism of transmission...
April 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28328159/improved-disease-activity-with-fosdagrocorat-pf-04171327-a-partial-agonist-of-the-glucocorticoid-receptor-in-patients-with-rheumatoid-arthritis-a-phase-2-randomized-study
#3
Thomas Stock, Dona Fleishaker, Xin Wang, Arnab Mukherjee, Charles Mebus
AIM: To assess efficacy and safety of fosdagrocorat (PF-04171327), a potential dissociated agonist of the glucocorticoid receptor, in rheumatoid arthritis (RA) patients. METHODS: This multicenter, double-blind, parallel-group, active- and placebo-controlled Phase 2 study (NCT00938587) randomized 86 patients (1 : 1 : 1 : 1) to receive fosdagrocorat 10 mg, fosdagrocorat 25 mg, prednisone 5 mg or placebo, all with stable background methotrexate therapy. The primary outcome was change from baseline in Disease Activity Score of 28 joints (DAS28-4[C-reactive protein (CRP)]) after 2 weeks of treatment...
March 22, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28323538/relationships-between-a-dissociative-subtype-of-ptsd-and-clinical-characteristics-in-patients-with-substance-use-disorders
#4
Michaela Mergler, Martin Driessen, Ursula Havemann-Reinecke, Dirk Wedekind, Christel Lüdecke, Martin Ohlmeier, Claudia Chodzinski, Sybille Teunißen, Steffen Weirich, Detlef Schläfke, Walter Renner, Ingo Schäfer, Gertrud Koesters, Christian Dette, Olaf Reis, Elisabeth H Sylvester, Martin Hoppe, Markus Stuppe, Thomas Broese, Udo Schneider, Christina Pletke
The increasing support for a dissociative subtype of post-traumatic stress disorder (PTSD-D) has led to its inclusion in DSM-5. We examined relationships between PTSD-D and relevant variables in patients with substance use disorders (SUD). The sample comprised N = 459 patients with SUD. The International Diagnostic Checklist and the Posttraumatic Diagnostic Scale were used to diagnose PTSD. In addition, participants completed the Childhood Trauma Questionnaire and the Dissociative Experiences Scale. The course of SUD was assessed by means of the European Addiction Severity Index...
March 21, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28318416/conflicts-between-motivational-systems-related-to-attachment-trauma-key-to-understanding-the-intra-family-relationship-between-abused-children-and-their-abusers
#5
Giovanni Liotti
Research on disorganization of infant attachment provides evidence that it can be caused not only by violent aggression or very early sexual abuse, but also by covert maltreating behavior, which includes the abdication of the caregiver's responsibility to soothe the infant's distress. This paper argues that both overtly abusive caregivers and merely "abdicating" caregivers may cause disorganization of infant attachment through a simultaneous and conflicting activation of the motivational systems governing attachment and survival defense in the infant...
March 1, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28318309/the-moderating-effect-of-risk-exposure-on-an-efficacious-intervention-for-maltreated-children
#6
Lindsey M Weiler, Heather N Taussig
The current study extends research on the impact of the Fostering Healthy Futures program (Taussig & Culhane, 2010), a 9-month mentoring and skills group preventive intervention for maltreated children, by examining whether the effect of Fostering Healthy Futures is moderated by children's baseline risk exposure (i.e., number of adverse childhood experiences). Participants included 156 racially and ethnically diverse children (ages 9-11, 50.7% female) recently placed in foster care due to maltreatment who were randomized to intervention or control conditions...
March 20, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28317337/role-of-transnasal-flexible-laryngo-oesophagoscopy-tnflo-in-investigating-patients-with-globus-symptoms
#7
Hassan Mohammed, Matthew Coates, Liam Masterson, Wei Yee Chan, Yasmeen Hassan, Ramez Nassif
Globus pharyngeus is the feeling of foreign body sensation in the throat. This feeling can be intermittent or persistent. In the past, the term "globus" was attributed to a psychological cause, hence the term "globus hystericus". The term "globus pharyngeus" was suggested in 1968 to dissociate the symptom from its psychological stigma. This article is protected by copyright. All rights reserved.
March 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28303109/the-effect-of-abuse-history-on-adolescent-patients-with-feeding-and-eating-disorders-treated-through-psychodynamic-therapy-comorbidities-and-outcome
#8
Annamaria M Strangio, Lucio Rinaldi, Gianluigi Monniello, Leuconoe Grazia Sisti, Chiara de Waure, Luigi Janiri
OBJECTIVES: The first aim of our study was to compare the characteristics and comorbidities of patients with eating disorders between those who suffered from a childhood abuse and those who did not. Our second aim was to analyze the differences in the outcome of the psychodynamic therapy between abused and not abused patients. METHODS: Twenty-six adolescent patients with eating disorders were assessed. Adolescent were evaluated by a single expert psychiatrist by checklists and questionnaires: EDI 3, SCL 90, BIS11, Dissociative Experiences Scale, Global Assessment of Functioning, SCID II, and CTQ-Self control (SF)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28302084/effectiveness-of-emdr-in-patients-with-substance-use-disorder-and-comorbid-ptsd-study-protocol-for-a-randomized-controlled-trial
#9
Ingo Schäfer, Laycen Chuey-Ferrer, Arne Hofmann, Peter Lieberman, Günter Mainusch, Annett Lotzin
BACKGROUND: Eye Movement Desensitization and Reprocessing (EMDR) is an evidence-based treatment for PTSD. However, it is unclear whether EMDR shows the same effectiveness in patients with substance use disorders (SUD) and comorbid PTSD. In this trial, we examine the effectiveness of EMDR in reducing PTSD symptoms in patients with SUD and PTSD. METHODS/DESIGN: We conduct a single-blinded RCT among 158 patients with SUD and comorbid PTSD admitted to a German addiction rehabilitation center specialized for the treatment of patients with SUD and comorbid PTSD...
March 16, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28301038/shame-dissociation-and-complex-ptsd-symptoms-in-traumatized-psychiatric-and-control-groups-direct-and-indirect-associations-with-relationship-distress
#10
Martin J Dorahy, Mary Corry, Rebecca Black, Laura Matheson, Holly Coles, David Curran, Lenaire Seager, Warwick Middleton, Kevin F W Dyer
OBJECTIVES: Elevated shame and dissociation are common in dissociative identity disorder (DID) and chronic posttraumatic stress disorder (PTSD) and are part of the constellation of symptoms defined as complex PTSD. Previous work examined the relationship between shame, dissociation, and complex PTSD and whether they are associated with intimate relationship anxiety, relationship depression, and fear of relationships. This study investigated these variables in traumatized clinical samples and a nonclinical community group...
April 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28299814/functional-neuroanatomical-associations-of-working-memory-in-early-onset-alzheimer-s-disease
#11
Christopher Kobylecki, Cathleen Haense, Jennifer M Harris, Cheryl L Stopford, Shailendra H Segobin, Matthew Jones, Anna M T Richardson, Alexander Gerhard, José Anton-Rodriguez, Jennifer C Thompson, Karl Herholz, Julie S Snowden
OBJECTIVE: To characterize metabolic correlates of working memory impairment in clinically defined subtypes of early-onset Alzheimer's disease. BACKGROUND: Established models of working memory suggest a key role for frontal lobe function, yet the association in Alzheimer's disease between working memory impairment and visuospatial and language symptoms suggests that temporoparietal neocortical dysfunction may be responsible. METHODS: Twenty-four patients with predominantly early-onset Alzheimer's disease were clinically classified into groups with predominantly amnestic, multidomain or visual deficits...
March 16, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28281939/childhood-traumatic-experiences-and-dissociative-phenomena-in-eating-disorders-level-and-association-with-the-severity-of-binge-eating-symptoms
#12
Giovanni L Palmisano, Marco Innamorati, Giovanna Susca, Denise Traetta, Diego Sarracino, Johan Vanderlinden
The aim of the current study is to evaluate the presence of childhood trauma, psychoform and somatoform dissociation in eating disorders (ED). 86 ED outpatients participated in this study, 20 of them were diagnosed with restrictive anorexia (AN-R), 10 of them with anorexia nervosa binge-purging subtypes (AN-B), 25 with bulimia nervosa (BN), and 31 with binge eating disorder (BED). They were matched by sex and age with a control group consisting of 86 healthy subjects (HC). Traumatic experiences were assessed by means of the Childhood Trauma Questionnaire (CTQ), psychological and somatoform dissociation respectively by means of the Dissociative Experience Scale (DES-II) and Somatoform Dissociation Questionnaire (SDQ-20), and binge eating symptoms by means of Binge Eating Scale (BES)...
March 10, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28281932/the-phenomenon-of-pathological-dissociation-in-the-ancient-chinese-medicine-literature
#13
Hong Wang Fung
Dissociative symptoms and disorders have been reported in many different cultures. If pathological dissociation is naturally occurring and related to adverse experiences, such phenomena should have been witnessed and portrayed before the modern age. To investigate whether this is the case, the author made use of the rich ancient Chinese medicine literature and looked for descriptions of pathological dissociation in medical documents written by ancient Chinese medical practitioners. In this paper, the author presents six cases selected from the ancient Chinese medicine literature...
March 10, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28281921/lateralization-of-neurobiological-response-in-adolescents-with-post-traumatic-stress-disorder-related-to-severe-childhood-sexual-abuse-the-tri-modal-reaction-t-mr-model-of-protection
#14
Tuba Mutluer, Vedat Şar, Çiğdem Kose-Demiray, Harun Arslan, Sibel Tamer, Serap Inal, Anıl Ş Kaçar
This study inquires into neurobiological response to stress and its clinical correlates among adolescents with post-traumatic stress disorder (PTSD). Structural magnetic resonance imaging (MRI) measures of cerebral anatomy were carried out on 23 female adolescents with PTSD related to severe childhood sexual abuse and 21 matched healthy controls. Clinician Administered PTSD Scale for Children and Adolescents, Adolescent Dissociative Experiences Scale, Childhood Trauma Questionnaire, Schedule for Affective Disorders and Schizophrenia for School Age Children, Beck Depression Scale and a set of neuro-cognitive tests were administered to all participants...
March 10, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28273660/other-persons-on-the-phenomenology-of-interpersonal-experience-in-schizophrenia-ancillary-article-to-eawe-domain-3
#15
Giovanni Stanghellini, Massimo Ballerini, Milena Mancini
In this paper, we discuss the philosophical and psychopathological background of Domain 3, Other persons, of the Examination of Anomalous World Experiences (EAWE). The EAWE interview aims to describe the manifold phenomena of the schizophrenic lifeworld in all of their concrete and distinctive features, thus complementing a more abstract, symptom-focused approach. Domain 3, Other persons, focuses specifically on subjectively experienced interpersonal disturbances that may be especially common in schizophrenia...
March 9, 2017: Psychopathology
https://www.readbyqxmd.com/read/28255445/a-failure-of-preoperative-duplex-imaging-to-diagnose-a-lower-extremity-venous-aneurysm-in-a-patient-with-severe-chronic-venous-insufficiency
#16
Roy Wesley Jones, Godfrey Ross Parkerson, Mary Ottinger, Eduardo Rodriguez, Brian Park
OBJECTIVE: We present a case of recurrent bilateral lower extremity venous stasis ulcers in association with a superficial venous aneurysm at the right saphenofemoral junction that was misdiagnosed on preoperative duplex scanning. METHODS: A 53-year-old female presented to our clinic with 6-year history of bilateral lower extremity venous stasis ulcers. Her past medical history was significant for refractory venous stasis ulcers of the bilateral lower extremities present for 6 years and morbid obesity...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28250569/dissociative-motor-disorder
#17
Arya Jith, Dinesh Narayanan
Conversion disorders are more prevalent in childhood and adolescence, especially in females. They are usually associated with stressors and symptoms usually reflect a means to avoid the stressor, or also with a primary and secondary gain. This case report involves a similar situation where a young girl was treated successfully with diazepam, therapeutic nerve conduction study, and behavioral psychotherapy.
January 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28242871/attenuation-of-ketamine-induced-impairment-in-verbal-learning-and-memory-in-healthy-volunteers-by-the-ampa-receptor-potentiator-pf-04958242
#18
M Ranganathan, N DeMartinis, B Huguenel, F Gaudreault, M M Bednar, C L Shaffer, S Gupta, J Cahill, M A Sherif, J Mancuso, L Zumpano, D C D'Souza
There is a need to develop treatments for cognitive impairment associated with schizophrenia (CIAS). The significant role played by N-methyl-d-aspartate receptors (NMDARs) in both the pathophysiology of schizophrenia and in neuronal plasticity suggests that facilitation of NMDAR function might ameliorate CIAS. One strategy to correct NMDAR hypofunction is to stimulate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) as AMPAR and NMDAR functioning are coupled and interdependent. In rats and nonhuman primates (NHP), AMPAR potentiators reduce spatial working memory deficits caused by the nonselective NMDAR antagonist ketamine...
February 28, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28239507/in-the-moment-dissociation-emotional-numbing-and-sexual-risk-the-influence-of-sexual-trauma-history-trauma-symptoms-and-alcohol-intoxication
#19
Cynthia A Stappenbeck, William H George, Jennifer Staples, Hong Nguyen, Kelly Cue Davis, Debra Kaysen, Julia R Heiman, N Tatiana Masters, Jeanette Norris, Cinnamon L Danube, Amanda K Gilmore, Kelly F Kajumulo
OBJECTIVE: Prior research on the effects of sexual trauma has examined dissociation but not emotional numbing during sex and has relied exclusively on retrospective surveys. The present experiment examined associations among distal factors of childhood sexual abuse (CSA), adolescent/adult sexual assault (ASA), and trauma symptoms and the proximal factor of acute alcohol intoxication on in-the-moment dissociation, emotional numbing, and sexual risk intentions. METHOD: Young adult female drinkers (N = 436) at elevated sexual risk were randomized to receive alcohol (target peak breath alcohol concentration = ...
October 2016: Psychology of Violence
https://www.readbyqxmd.com/read/28236065/glioblastoma-spheroids-produce-infiltrative-gliomas-in-the-rat-brainstem
#20
Zhiping Zhou, Neal Luther, Ranjodh Singh, John A Boockvar, Mark M Souweidane, Jeffrey P Greenfield
PURPOSE: Diffuse intrinsic pontine glioma (DIPG) is universally fatal without proven therapy other than radiation therapy for palliation. Representative animal models will play an essential role in the preclinical stage of future therapy development. To address the shortage of representative models, we created a novel infiltrative brainstem glioma model in rats based on glioblastoma spheroids. METHODS: Cells dissociated from glioblastoma spheroids grown from surgical specimens were implanted into the brainstem of NIH nude rats...
February 24, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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