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https://www.readbyqxmd.com/read/28924184/genetic-contributions-to-trail-making-test-performance-in-uk-biobank
#1
S P Hagenaars, S R Cox, W D Hill, G Davies, D C M Liewald, S E Harris, A M McIntosh, C R Gale, I J Deary
The Trail Making Test (TMT) is a widely used test of executive function and has been thought to be strongly associated with general cognitive function. We examined the genetic architecture of the TMT and its shared genetic aetiology with other tests of cognitive function in 23 821 participants from UK Biobank. The single-nucleotide polymorphism-based heritability estimates for trail-making measures were 7.9% (part A), 22.4% (part B) and 17.6% (part B-part A). Significant genetic correlations were identified between trail-making measures and verbal-numerical reasoning (rg>0...
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28918573/anti-inflammatory-effects-of-ginkgo-biloba-extract-against-trimethyltin-induced-hippocampal-neuronal-injury
#2
Sukhwinder Kaur, Neha Sharma, Bimla Nehru
BACKGROUND: Despite the immense neuromodulatory potentials of Ginkgo biloba extract as a memory enhancer, its underlying mechanism seems inadequate particularly with regard to its anti-inflammatory properties. AIM: The objective of the present study is to investigate the protective potentials of Ginkgo biloba extract (GBE) against hippocampal neuronal injury induced by trimethyltin (TMT), a potent neurotoxicant. METHODS: Male SD rats were administered trimethyltin (8...
September 16, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28912737/neuropsychological-profile-of-specific-executive-dysfunctions-in-patients-with-deficit-and-non-deficit-schizophrenia
#3
Ernest Tyburski, Justyna Pełka-Wysiecka, Monika Mak, Agnieszka Samochowiec, Przemysław Bieńkowski, Jerzy Samochowiec
Objectives: Although it has been shown that there are more profound deficits present in deficit schizophrenia (DS) patients than in non-deficit schizophrenia (NDS) patients, there still remain some matters requiring further investigation. In this context, we formulated three research aims: (1) to compare executive functions between the investigated groups, (2) to determine the relationship between particular aspects of executive functions within the groups, and (3) to draw up a neuropsychological profile for executive functions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28912013/acid-sensing-ion-channel-1-contributes-to-normal-olfactory-function
#4
Kiara T Vann, Zhi-Gang Xiong
Acid-sensing ion channels (ASICs) are cation channels activated by protons. ASIC1a, a primary ASIC subunit in the brain, was recently characterized in the olfactory bulb. The present study tested the hypothesis that ASIC1a is essential for normal olfactory function. Olfactory behavior of wild-type (WT) and ASIC1-/- mice was evaluated by using three standard olfactory tests: (1) the buried food test, (2) the olfactory habituation test, and (3) the olfactory preference test. In buried food test, ASIC1-/- mice had significantly longer latency to uncover buried food than WT mice...
September 11, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28904971/cognitive-or-cognitive-motor-executive-function-tasks-evaluating-verbal-fluency-measures-in-people-with-parkinson-s-disease
#5
Alessandra Ferreira Barbosa, Mariana Callil Voos, Janini Chen, Debora Cristina Valente Francato, Carolina de Oliveira Souza, Egberto Reis Barbosa, Hsin Fen Chien, Letícia Lessa Mansur
INTRODUCTION: Executive function deficits are observed in people with Parkinson's disease (PD) from early stages and have great impact on daily living activities. Verbal fluency and oral diadochokinesia involve phonarticulatory coordination, response inhibition, and phonological processing and may also be affected in people with PD. This study aimed to describe the performance of PD patients and an age- and education-matched control group on executive function, verbal fluency, and oral diadochokinesia tests and to investigate possible relationships between them...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28903049/a-mass-spectrometry-based-approach-for-mapping-protein-subcellular-localization-reveals-the-spatial-proteome-of-mouse-primary-neurons
#6
Daniel N Itzhak, Colin Davies, Stefka Tyanova, Archana Mishra, James Williamson, Robin Antrobus, Jürgen Cox, Michael P Weekes, Georg H H Borner
We previously developed a mass spectrometry-based method, dynamic organellar maps, for the determination of protein subcellular localization and identification of translocation events in comparative experiments. The use of metabolic labeling for quantification (stable isotope labeling by amino acids in cell culture [SILAC]) renders the method best suited to cells grown in culture. Here, we have adapted the workflow to both label-free quantification (LFQ) and chemical labeling/multiplexing strategies (tandem mass tagging [TMT])...
September 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/28899369/nursing-care-needs-and-services-utilised-by-home-dwelling-elderly-with-complex-health-problems-observational-study
#7
Gro Næss, Marit Kirkevold, Wenche Hammer, Jørund Straand, Torgeir Bruun Wyller
BACKGROUND: In Norway, as in many Western countries, a shift from institutional care to home care is taking place. Our knowledge is limited regarding which needs for nursing interventions patients being cared for in their home have, and how they are met. We aimed at assessing aspects of health and function in a representative sample of the most vulnerable home-dwelling elderly, to identify their needs for nursing interventions and how these needs were met. METHODS: In this observational study we included patients aged 75+ living in their own homes in Oslo, who received daily home care, had three or more chronic diagnoses, received daily medication, and had been hospitalized during the last year...
September 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28895868/identification-of-novel-biomarkers-for-treatment-monitoring-in-canine-leishmaniosis-by-high-resolution-quantitative-proteomic-analysis
#8
Silvia Martinez-Subiela, Anita Horvatic, Damian Escribano, Luis Pardo-Marin, Meric Kocaturk, Vladimir Mrljak, Richard Burchmore, Jose J Ceron, Zeki Yilmaz
The objective of this study was to use the Tandem Mass Tag (TMT) isobaric label-based proteomic approach, in order to identify new potential biomarkers for the treatment monitoring of canine leishmaniosis that could not be identified by the use of gel-based techniques. For this purpose serum samples were obtained from 5 clinically diseased dogs before and one month after the treatment of canine leishmaniosis. The non-depleted serum samples were subjected to reduction, alkylation and trypsin digestion, and the resulting peptides were labeled using 6-plex TMT reagents...
September 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28890054/home-cage-odors-spatial-cues-elicit-theta-phase-gamma-amplitude-coupling-between-olfactory-bulb-and-dorsal-hippocampus
#9
Roberta Ribas Pena, Daniel de Castro Medeiros, Leonardo de Oliveira Guarnieri, Julio Boriollo Guerra, Vinícius Rezende Carvalho, Eduardo Mazoni Andrade Marçal Mendes, Grace Schenatto Pereira, Márcio Flávio Dutra Moraes
The brain oscillations may play a critical role in synchronizing neuronal assemblies in order to establish appropriate sensory-motor integration. In fact, studies have demonstrated phase-amplitude coupling of distinct oscillatory rhythms during cognitive processes. Here we investigated whether olfacto-hippocampal coupling occurs when mice are detecting familiar odors located in a spatially restricted area of a new context. The spatial olfactory task (SOT) was designed to expose mice to a new environment in which only one quadrant (target) contains odors provided by its own home-cage bedding...
September 7, 2017: Neuroscience
https://www.readbyqxmd.com/read/28884396/ginsenoside-re-protects-trimethyltin-induced-neurotoxicity-via-activation-of-il-6-mediated-phosphoinositol-3-kinase-akt-signaling-in-mice
#10
Thu-Hien Thi Tu, Naveen Sharma, Eun-Joo Shin, Hai-Quyen Tran, Yu Jeung Lee, Ji Hoon Jeong, Jung Hwan Jeong, Seung Yeol Nah, Hoang-Yen Phi Tran, Jae Kyung Byun, Sung Kwon Ko, Hyoung-Chun Kim
Ginseng (Panax ginseng), an herbal medicine, has been used to prevent neurodegenerative disorders. Ginsenosides (e.g., Re, Rb1, or Rg1) were obtained from Korean mountain cultivated ginseng. The anticonvulsant activity of ginsenoside Re (20 mg/kg/day × 3) against trimethyltin (TMT) insult was the most pronounced out of ginsenosides (e.g., Re, Rb1, and Rg1). Re itself did not significantly alter tumor necrosis factor-α (TNF-α), interferon-ϒ (IFN-ϒ), and interleukin-1β (IL-1β) expression, however, it significantly increases the interleukin-6 (IL-6) expression...
September 7, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28874504/proteome-analysis-of-hypoxic-glioblastoma-cells-reveals-sequential-metabolic-adaptation-nbsp-of-one-carbon-metabolic-pathways
#11
Kangling Zhang, Pei Xu, James L Sowers, Daniel F Machuca, Barsam Mirfattah, Jason Herring, Hui Tang, Yan Chen, Bing Tian, Allan R Brasier, Lawrence C Sowers
Rapidly proliferating tumors are exposed to a hypoxic microenvironment due to their density, high metabolic consumption, and interruptions in blood flow due to immature angiogenesis. Cellular responses to hypoxia promote highly malignant and metastatic behavior, as well as a chemotherapy-resistant state. In order to better understand the complex relationships between hypoxic adaptations and cancer progression, we studied the dynamic proteome responses of glioblastoma cells exposed to hypoxia via an innovative approach: quantification of newly synthesized proteins using heavy stable-isotope arginine labeling combined with accurate assessment of cell replication by quantification of the light/heavy arginine ratio of peptides in histone H4...
September 5, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28870862/incidence-clinicopathologic-risk-factors-management-and-outcomes-of-non-muscle-invasive-recurrences-after-complete-response-to-tri-modality-therapy-for-muscle-invasive-bladder-cancer
#12
Alejandro Sanchez, Matthew F Wszolek, Andrzej Niemierko, Rebecca H Clayman, Michael Drumm, Dayron Rodríguez, Adam S Feldman, Douglas M Dahl, Niall M Heney, William U Shipley, Anthony L Zietman, Jason A Efstathiou
PURPOSE: To describe the incidence, clinicopathologic risk factors, management, and outcomes of non-muscle invasive bladder cancer (NMIBC) recurrences after complete response (CR) to tri-modality therapy (TMT) for muscle-invasive bladder cancer (MIBC). MATERIALS AND METHODS: Patients with cT2-4aN0M0 MIBC (n=342) and CR after TMT were reviewed retrospectively (1986-2013). Using competing risks analyses, the association between baseline clinicopathologic variables and NMIBC outcomes was examined...
September 1, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28870009/comprehensive-analysis-of-proteomic-differences-between-escherichia-coli-k-12-and-b-strains-using-multiplexed-isobaric-tandem-mass-tag-tmt-labeling
#13
Mee-Jung Han
The Escherichia coli K-12 and B strains are among the most frequently used bacterial hosts for scientific research and biotechnological applications. However, omics analyses have revealed that E. coli K-12 and B exhibit notably different genotypic and phenotypic attributes, even though they were derived from the same ancestor. In a previous study, we identified a limited number of proteins from the two strains using two-dimensional gel electrophoresis and tandem mass spectrometry (MS/MS). In this study, an in-depth analysis of the physiological behavior of the E...
September 5, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28866169/peptide-functionalized-poly-ethylene-glycol-poly-caprolactone-nanomicelles-for-specific-cabazitaxel-delivery-to-metastatic-breast-cancer-cells
#14
Parvin Mahdaviani, Saeed Bahadorikhalili, Mona Navaei-Nigjeh, Seyed Yaser Vafaei, Mehdi Esfandyari-Manesh, Amir Hossein Abdolghaffari, Zahra Daman, Fatemeh Atyabi, Mohammad Hossein Ghahremani, Mohsen Amini, Afsaneh Lavasanifar, Rassoul Dinarvand
Metastatic cancer is responsible for 90% of deaths in world. Usage of nano-carriers improve the delivery and efficacy of chemotherapeutic agents. Recent studies suggest that decoration of the surface of nano-carriers with various targeting agents may further improve their overall therapeutic efficacy. Using specified peptides in targeted drug delivery is a key point in recent researches. In this study, tumor metastasis targeting (TMT) homing peptide was applied as a targeting group to improve specific drug delivery to tumor cells...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28865911/trauma-management-therapy-with-virtual-reality-augmented-exposure-therapy-for-combat-related-ptsd-a-randomized-controlled-trial
#15
Deborah C Beidel, B Christopher Frueh, Sandra M Neer, Clint A Bowers, Benjamin Trachik, Thomas W Uhde, Anouk Grubaugh
Virtual reality exposure therapy (VRET) realistically incorporates traumatic cues into exposure therapy and holds promise in the treatment of combat-related posttraumatic stress disorder (PTSD). In a randomized controlled trial of 92 Iraq and Afghanistan veterans and active duty military personnel with combat-related PTSD, we compared the efficacy of Trauma Management Therapy (TMT; VRET plus a group treatment for anger, depression, and social isolation) to VRET plus a psychoeducation control condition. Efficacy was evaluated at mid- and post-treatment, and at 3- and 6-month follow-up...
August 23, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28865241/processing-speed-and-the-relationship-between-trail-making-test-b-performance-cortical-thinning-and-white-matter-microstructure-in-older-adults
#16
Sarah E MacPherson, Simon R Cox, David A Dickie, Sherif Karama, John M Starr, Alan C Evans, Mark E Bastin, Joanna M Wardlaw, Ian J Deary
Part B of the Trail Making Test (TMT-B) is widely used as a quick and easy to administer measure of executive dysfunction. The current study investigated the relationships between TMT-B performance, brain volumes, cortical thickness and white matter water diffusion characteristics in a large sample of older participants, before and after controlling for processing speed. Four hundred and eleven healthy, community-dwelling older adults who were all born in 1936 were assessed on TMT-B, 5 tests of processing speed, and provided contemporaneous structural and diffusion MRI data...
August 9, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28862474/tympanic-membrane-temperature-decreases-during-head-up-tilt-relation-to-frontal-lobe-oxygenation-and-middle-cerebral-artery-mean-blood-flow-velocity
#17
David Lorr, Anton Lund, Mats Fredrikson, Niels H Secher
INTRODUCTION: Changes in blood flow influence temperature of surrounding tissues. Since the internal carotid artery (ICA) and internal jugular vein (IJV) neighbor the tympanic membrane, changes in their blood flow most likely determine changes in tympanic membrane temperature (TMT). We sought to evaluate the relationship between changes during a head-up tilt (HUT) induced reduction in cerebral blood flow (CBF) and TMT. METHODS: Ten male subjects (age 19-28 years) underwent 50° HUT until presyncope...
September 1, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28861165/association-of-ecrg4-with-plk1-cdk4-plod1-and-plod2-in-esophageal-squamous-cell-carcinoma
#18
Linwei Li, Wenyu Wang, Xiaoyan Li, Tianhui Gao
Esophageal cancer-related gene 4 (ECRG4) is a tumor suppressor gene associated with the prognosis of esophageal squamous-cell carcinoma (ESCC). Studies have reported that ECRG4 effectively inhibits the proliferation, migration and invasion of ESCC cells. In the current study, ectopic expression of ECRG4 significantly induced ESCC cell apoptosis. To further understand the molecular profile of ECRG4 overexpression in ESCC cells, tandem mass tag (TMT) labeling followed by LC-MS/MS analysis was applied on samples from ECRG4 overexpressed cells and control cells...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28846745/comparison-of-cognitive-and-brain-grey-matter-volume-profiles-between-multiple-sclerosis-and-neuromyelitis-optica-spectrum-disorder
#19
Hiroki Masuda, Shigeki Hirano, Nobuyoshi Takahashi, Etsuko Hatsugano, Akiyuki Uzawa, Tomohiko Uchida, Ryohei Ohtani, Satoshi Kuwabara, Masahiro Mori
OBJECTIVE: Brain regions responsible for cognitive dysfunction in MS and neuromyelitis optica spectrum disorder (NMOSD) are not known. Our aim of this study was to investigate whether cognitive function and brain volume differed between MS and NMOSD in Japanese patients. METHODS: Brain MRI and neuropsychological tests including the Wechsler Adult Intelligence Scale-III (WAIS-III), Wechsler Memory Scale-Revised (WMS-R), Trail Making Test (TMT) and Clinical Assessment for Attention (CAT) were performed...
2017: PloS One
https://www.readbyqxmd.com/read/28832155/pseudomonas-aeruginosa-proteome-under-hypoxic-stress-conditions-mimicking-the-cystic-fibrosis-lung
#20
Karthik Shantharam Kamath, Christoph Krisp, Joel Chick, Dana Pascovici, Steven P Gygi, Mark P Molloy
Pseudomonas aeruginosa is a ubiquitous Gram-negative pathogen known to inhabit hypoxic mucus plugs of cystic fibrosis (CF) patient lungs. Despite the high prevalence and related patient mortality, the protein machinery enabling the bacterium to adapt to low oxygen environment remains to be fully elucidated. We investigated this by performing both SWATH mass spectrometry and data-dependent SPS-MS3 of TMT-labeled peptides to profile the proteomes of two P. aeruginosa CF isolates, PASS2 and PASS3, and a laboratory reference strain, PAO1, grown under hypoxic stress (O2 < 1%) in media that mimic the nutrient components of the CF lung...
August 31, 2017: Journal of Proteome Research
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