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https://www.readbyqxmd.com/read/29772805/ethyl-acetate-fraction-from-persimmon-diospyros-kaki-ameliorates-cerebral-neuronal-loss-and-cognitive-deficit-via-the-jnk-akt-pathway-in-tmt-induced-mice
#1
Jong Min Kim, Seon Kyeong Park, Jin Yong Kang, Su Bin Park, Seul Ki Yoo, Hye Ju Han, Chul-Woo Kim, Uk Lee, Sea-Hyun Kim, Ho Jin Heo
This study was conducted to assess the antioxidant capacity and protective effect of the ethyl acetate fraction from persimmon ( Diospyros kaki ) (EFDK) on H₂O₂-induced hippocampal HT22 cells and trimethyltin chloride (TMT)-induced Institute of Cancer Research (ICR) mice. EFDK had high antioxidant activities and neuroprotective effects in HT22 cells. EFDK ameliorated behavioral and memory deficits in Y-maze, passive avoidance and Morris water maze tests. Also, EFDK restored the antioxidant system by regulating malondialdehyde (MDA), superoxide dismutase (SOD) and reduced gluthathione (GSH), and the cholinergic system by controlling the acetylcholine (ACh) level and acetylcholinesterase (AChE) activity and expression...
May 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29771202/analysing-healthcare-coordination-using-translational-mobilization
#2
Davina Allen
Purpose The purpose of this paper is to introduce translational mobilization theory (TMT) and explore its application for healthcare quality improvement purposes. Design/methodology/approach TMT is a generic sociological theory that explains how projects of collective action are progressed in complex organizational contexts. This paper introduces TMT, outlines its ontological assumptions and core components, and explores its potential value for quality improvement using rescue trajectories as an illustrative case...
May 21, 2018: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/29765585/a-study-of-the-effects-of-daily-physical-activity-on-memory-and-attention-capacities-in-college-students
#3
Dinh-Van Phan, Chien-Lung Chan, Ren-Hao Pan, Nan-Ping Yang, Hsiu-Chen Hsu, Hsien-Wei Ting, K Robert Lai
This study evaluated the relationship between daily physical activity (DPA) and memory capacity, as well as the association between daily activity and attention capacity, in college students in Taiwan. Participants (mean age = 20.79) wore wearable trackers for 106 days in order to collect DPA. These data were analyzed in association with their memory and attention capacities, as assessed using the spatial span test (SST) and the trail making test (TMT). The study showed significant negative correlations between memory capacity, time spent on the attention test (TSAT), calories burnt, and very active time duration (VATD) on the day before testing ( r = -0...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29764877/efficacy-of-practising-tai-chi-for-older-people-with-mild-dementia-protocol-for-a-randomised-controlled-study
#4
Jihui Lyu, Wenjie Li, Xiangjiang Rong, Lian Wei, Nayan Huang, Mei Champ, Qian Xiong, Xueli Chen, Mo Li, Fangling Li
INTRODUCTION: Many studies suggest that Tai Chi exercise is a safe and appropriate mind-body exercise for older people and effectively slows down age-related cognitive decline. A set of bespoke Tai Chi exercise named 'Cognition Protecting Tai Chi' (CPT) has been created for older people with cognitive impairments by the research team of geriatricians, neurologists, rehabilitation specialists, experts of sports medicine and experienced practitioners of traditional Chinese medicine. This trial is designed to evaluate its effects on cognitive function, behaviour/moods, risk of falls and activities of daily living of the participants with mild dementia...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29764237/neuroprotective-effect-of-clavulanic-acid-on-trimethyltin-tmt-induced-cytotoxicity-in-pc12-cells
#5
Samaneh Silakhori, Hossein Hosseinzadeh, Fatemeh Shaebani Behbahani, Soghra Mehri
Trimethyltin (TMT) is a short-chain trialkyltin with various applications in industry. In addition, it is a known neurotoxin, producing significant and selective neurodegeneration in the limbic system of both human and animals. Recently, effect of clavulanic acid (CA) in nervous system has been mentioned. Therefore, in this study, the role of CA in TMT-induced toxicity in PC12 cells was evaluated. For this study, PC12 cells were cultured and exposed to different concentrations of CA for 24 h. Then, TMT (20 µM) was added to cells...
May 15, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29763921/peptidomic-analysis-of-endometrial-tissue-from-patients-with-ovarian-endometriosis
#6
Yunping Xue, Pengfei Xu, Sujuan Xu, Kai Xue, Lingling Xu, Jie Chen, Juan Xu, Xiaoyan Shi, Qian Li, Lin Gu
BACKGROUND/AIMS: Ovarian endometriosis (OvE) is ovarian cyst that is lined with endometrial tissue. They are found in 17-44% of women with endometriosis. Their clinical manifestations include pelvic pain, dysmenorrhea, dyspareunia, and infertility. Although the incidence of OvE has increased yearly, the exact pathogenesis of OvE is still unclear. We used peptidomics, an emerging branch of proteomics, to identify differentially expressed peptides in order to determine the possible roles of these peptides in the pathogenesis of OvE...
May 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29753649/comparison-of-subacute-and-chronic-scar-tissues-after-complete-spinal-cord-transection
#7
Xing Li, Bin Yang, Zhifeng Xiao, Yannan Zhao, Sufang Han, Yanyun Yin, Bing Chen, Jianwu Dai
Traditional views consider scar tissue formed in the lesion epicenter after severe spinal cord injury (SCI) as both a physical barrier and chemical impediment for axonal regeneration. Recently, a controversial opinion suggested that astrocyte scar formation aids rather than prevents axonal regeneration in the CNS. Here, following complete transection of the thoracic spinal cord (T8) in rats, we found that scar tissue showed greater growth factor expression at 2 weeks than 8 weeks post-SCI. Further, tandem mass tag (TMT)-based quantitative proteomic analysis revealed that the components of scar tissue formed in the subacute phase are quite different from that formed in the chronic phase...
May 10, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29740960/stable-protein-gel-storage-in-acetonitrile-for-mass-spectrometric-analysis
#8
Yuxin Chen, Sen Wang, Jia Jia, Xinyu Tian, Hongpan Xu, Mingzhe Ning, Bing Bai
Long-term storage of protein samples for transportation is a challenge in the field of mass spectrometric analysis because the low temperature condition is not easy to be maintained. Here we introduce a simple method to preserve proteins at room temperature for at lease one month. In this method, the protein sample is run shortly into a polyacrylamide gel which is then excised after Coomassie staining. The protein gel band is then dehydrated by 100% acetonitrile for three times and kept in the 100% acetonitrile for storage at the room temperature...
May 8, 2018: Proteomics
https://www.readbyqxmd.com/read/29739064/serum-proteomic-analysis-by-tandem-mass-tags-tmt-based-quantitative-proteomics-in-gastric-cancer-patients
#9
Aidan Huang, Meiyu Zhang, Taijie Li, Xue Qin
BACKGROUND: To use the tandem mass tags (TMT) based quantitative proteomics technique and bioinformatics method to identify potential serum diagnostic biomarkers for gastric cancer (GC). METHODS: This study enrolled GC patients and healthy control subjects. Mixed serum samples were pooled with 10 individual samples. The high-abundance proteins depleted serum proteins were collected by removing abundance albumin and immunoglobulin G (IgG). After desalting and ultrafiltration, the trypsin digested proteins were analyzed using TMT based quantitative proteomics system...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29736060/improvement-in-neurocognitive-functions-and-serum-brain-derived-neurotrophic-factor-levels-in-patients-with-depression-treated-with-antidepressants-and-yoga
#10
Naveen Gowrapura Halappa, Jagadisha Thirthalli, Shivarama Varambally, Mukund Rao, Rita Christopher, Gangadhar B Nanjundaiah
Context and Aims: Impairment in cognition is well-known in patients with major depressive disorder. This study examined the effect of yoga therapy with or without antidepressants and antidepressants alone on certain neuropsychological functions in patients with depression. Correlation between changes in neuropsychological test performance and serum brain-derived neurotrophic factor (BDNF) levels was also explored. Materials and Methods: Antidepressant-naïve/antidepressant-free outpatients with depression received antidepressant medication alone ( n = 23) or yoga therapy with ( n = 26) or without ( n = 16) antidepressants...
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29736011/s-nitrosylation-of-nos-pathway-mediators-in-the-penis-contributes-to-cavernous-nerve-injury-induced-erectile-dysfunction
#11
Biljana Musicki, Anil K Bhunia, Serkan Karakus, Arthur L Burnett
cGMP-independent nitric oxide (NO) signaling occurs via S-nitrosylation. We evaluated whether aberrant S-nitrosylation operates in the penis under conditions of cavernous nerve injury and targets proteins involved in regulating erectile function. Adult male Sprague-Dawley rats underwent bilateral cavernous nerve crush injury (BCNI) or sham surgery. Rats were given a denitrosylation agent N-acetylcysteine (NAC, 300 mg/kg/day) or vehicle in drinking water starting 2 days before BCNI and continuing for 2 weeks following surgery...
May 8, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29735975/efficacy-of-acupuncture-therapy-for-chemotherapy-related-cognitive-impairment-in-breast-cancer-patients
#12
Taishan Tong, Chunqin Pei, Jun Chen, Qing Lv, Fuquan Zhang, Zaohuo Cheng
BACKGROUND Chemotherapy can cause adverse effects such as chemotherapy-related cognitive impairment (CRCI). In this prospective study, the efficacy of traditional Chinese medicine acupuncture therapy in relieving CRCI and its impact on serum brain-derived neurotrophic factor (BDNF) are evaluated. MATERIAL AND METHODS Eighty patients were randomly divided into a treatment group and a control group with 40 patients in each group. The treatment group was treated at the following acupuncture points: Baihui (DU20), Sishencong (EX-HN1), Shenting (DU24), Zusanli (ST36), Taixi (K13), Dazhong (K14), and Juegu (GB39)...
May 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29734811/streamlined-tandem-mass-tag-sl-tmt-protocol-an-efficient-strategy-for-quantitative-phospho-proteome-profiling-using-tandem-mass-tag-synchronous-precursor-selection-ms3
#13
José Navarrete-Perea, Qing Yu, Steven P Gygi, Joao A Paulo
Mass spectrometry (MS) coupled toisobaric labeling has developed rapidly into a powerful strategy for high-throughput protein quantification. Sample multiplexing and exceptional sensitivity allow for the quantification of tens of thousands of peptides and, by inference, thousands of proteins from multiple samples in a single MS experiment. Accurate quantification demands a consistent and robust sample-preparation strategy. Here, we present a detailed workflow for SPS-MS3-based quantitative abundance profiling of tandem mass tag (TMT)-labeled proteins and phosphopeptides that we have named the streamlined (SL)-TMT protocol...
May 16, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29733470/-tmt-n-clusters-as-dilute-debris-free-tin-source-for-generation-of-multiply-charged-tin-ions-of-relevance-in-extreme-ultraviolet-euv-lithography-under-intense-laser-irradiation
#14
Pramod Sharma, Soumitra Das, Rajesh K Vatsa
RATIONALE: Multiply charged tin ions ([Sn]8+ to [Sn]13+ ) are considered as ideal-emitters at extreme ultraviolet (EUV) wavelength ~ 13.5 nm, pertinent to advanced micro-electronic device fabrication. Solid tin targets have been widely explored for the generation of these ions, but debris generation has restricted their utilization. Tin-containing molecular clusters have, however, the potential to act as dilute and debris-free sources for the generation of tin ions, as investigated in the present study...
May 7, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29728056/proteomics-integrated-with-metabolomics-analysis-of-the-internal-causes-of-nutrient-changes-in-alfalfa-at-different-growth-stages
#15
Wenqiang Fan, Gentu Ge, Yinghao Liu, Wei Wang, Liying Liu, Yushan Jia
BACKGROUND: Alfalfa (Medicago sativa L.) is one of the most important forage resources in the world due to its high nutritive value. However, its nutritional quality decreases during the transition from budding to flowering. Previous research revealed a decreased crude protein content and increased fibre content in alfalfa forage harvested at later maturity stages, leading to a reduction in nutritional quality. However, the reasons for this phenomenon have not been explained at the molecular level...
May 4, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29726510/analysis-and-correction-for-measurement-error-of-edge-sensors-caused-by-deformation-of-guide-flexure-applied-in-the-thirty-meter-telescope-ssa
#16
Haifeng Cao, Jingxu Zhang, Fei Yang, Qichang An, Hongchao Zhao, Peng Guo
The Thirty Meter Telescope (TMT) project will design and build a 30-m-diameter telescope for research in astronomy in visible and infrared wavelengths. The primary mirror of TMT is made up of 492 hexagonal mirror segments under active control. The highly segmented primary mirror will utilize edge sensors to align and stabilize the relative piston, tip, and tilt degrees of segments. The support system assembly (SSA) of the segmented mirror utilizes a guide flexure to decouple the axial support and lateral support, while its deformation will cause measurement error of the edge sensor...
May 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29726305/trail-making-tests-a-and-b-regression-based-normative-data-for-quebec-french-speaking-mid-and-older-aged-adults
#17
Alexandre St-Hilaire, Camille Parent, Olivier Potvin, Louis Bherer, Jean-François Gagnon, Sven Joubert, Sylvie Belleville, Maximiliano A Wilson, Lisa Koski, Isabelle Rouleau, Carol Hudon, Joël Macoir
OBJECTIVE: The Trail Making Test (TMT) is mainly used to assess visual scanning/processing speed (part A) and executive functions (part B). The test has proven sensitive at detecting cognitive impairment during aging. However, previous studies have shown differences between normative data from different countries and cultures, even when corrected for age and education. Such inconsistencies between normative data may lead to serious diagnostic errors, thus, the development of local norms is warranted...
May 4, 2018: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29717334/the-role-of-striatal-dopamine-d-2-3-receptors-in-cognitive-performance-in-drug-free-patients-with-schizophrenia
#18
Tanja Veselinović, Ingo Vernaleken, Hildegard Janouschek, Paul Cumming, Michael Paulzen, Felix M Mottaghy, Gerhard Gründer
OBJECTIVE: A considerable body of research links cognitive function to dopaminergic transmission in the prefrontal cortex, but less is known about cognition in relation to striatal dopamine D2/3 receptors in unmedicated patients with psychosis. METHODS: We investigated this association by obtaining PET recordings with the high-affinity D2/3 antagonist ligand [18 F] fallypride in 15 medication-free patients with schizophrenia and 11 healthy controls. On the day of PET scanning, we undertook comprehensive neuropsychological testing and assessment of psychopathology using the Positive and Negative Syndrome Scale (PANSS)...
May 1, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29695160/an-adaptive-pipeline-to-maximize-isobaric-tagging-data-in-large-scale-ms-based-proteomics
#19
John Corthésy, Konstantinos Theofilatos, Seferina Mavroudi, Charlotte Macron, Ornella Cominetti, Mona Remlawi, Francesco Ferraro, Antonio Núñez Galindo, Martin Kussmann, Spiridon Likothanassis, Loïc Dayon
Isobaric tagging is the method of choice in mass-spectrometry-based proteomics for comparing several conditions at a time. Despite its multiplexing capabilities, some drawbacks appear when multiple experiments are merged for comparison in large sample-size studies due to the presence of missing values, which result from the stochastic nature of the data-dependent acquisition mode. Another indirect cause of data incompleteness might derive from the proteomic-typical data-processing workflow that first identifies proteins in individual experiments and then only quantifies those identified proteins, leaving a large number of unmatched spectra with quantitative information unexploited...
May 4, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29683777/relationship-between-posturography-clinical-balance-and-executive-function-in-parkinson%C3%A2-s-disease
#20
Carolina de Oliveira Souza, Mariana Callil Voos, Alessandra Ferreira Barbosa, Janini Chen, Debora Cristina Valente Francato, Matija Milosevic, Milos Popovic, Erich Talamoni Fonoff, Hsin Fen Chien, Egberto Reis Barbosa
This study aimed to evaluate the relationship between posturography, clinical balance, and executive function tests in Parkinson´s disease (PD). Seventy-one people participated in the study. Static posturography evaluated the center of pressure fluctuations in quiet standing and dynamic posturography assessed sit-to-stand, tandem walk, and step over an obstacle. Functional balance was evaluated by Berg Balance Scale, MiniBESTest, and Timed Up and Go test. Executive function was assessed by Trail Making Test (TMT) and semantic verbal fluency test...
April 23, 2018: Journal of Motor Behavior
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