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https://www.readbyqxmd.com/read/27924662/empathy-and-its-relationship-with-cognitive-and-emotional-functions-in-alcohol-dependency
#1
Almila Erol, Asusinem Akyalcin Kirdok, Nabi Zorlu, Serap Polat, Levent Mete
BACKGROUND: Empathy can be defined as the ability to understand the other's thoughts and feelings. It contains both cognitive and emotional components. AIMS: The aim of this study was to investigate the empathy ability of patients with alcohol dependency in association with cognitive and emotional functions, after acute detoxification and during long-term abstinence. METHODS: Thirty-three alcohol dependent inpatients that completed a detoxification process and stayed abstinent throughout the study, and 33 healthy comparison subjects that matched the patients for age, gender, and education level were included in the study...
December 7, 2016: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/27922623/molecular-mechanisms-underlying-the-positive-role-of-treadmill-training-in-locomotor-recovery-after-spinal-cord-injury
#2
Q Liu, B Zhang, C Liu, D Zhao
OBJECTIVES: This study aimed to investigate the molecular mechanisms underlying the positive role of treadmill training (TMT) in locomotor recovery. METHODS: GSE52763 microarray data were downloaded from GEO database, which was collected from the lumbar spinal cord samples of three groups of mice: mice subjected to contusive injury and killed 1 week after injury (I1), mice subjected to injury and killed 3 weeks after injury (I3), and mice subjected to injury and TMT beginning at week 1 and lasting until week 3 (T3)...
December 6, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27921860/effects-of-cognitive-remediation-therapy-on-neurocognition-and-negative-symptoms-in-schizophrenia-an-italian-naturalistic-study
#3
Mariangela Lanfredi, Giacomo Deste, Clarissa Ferrari, Stefano Barlati, Laura Rosa Magni, Roberta Rossi, Luca de Peri, Marco Bonomi, Giuseppe Rossi, Antonio Vita
INTRODUCTION: Cognitive remediation therapy (CRT) has been reported to positively affect neurocognitive processes among patients with schizophrenia; however, the degree to which changes in cognition is linked to improved clinical symptoms, remains poorly understood. The current study aimed to investigate whether cognitive gains were associated to improvements in negative symptoms' severity in patients with schizophrenia living in two Italian psychiatric facilities. METHODS: Patients with a diagnosis of schizophrenia were consecutively assigned to CRT (n = 33) and compared with an historical control group (n = 28)...
December 6, 2016: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/27917875/exploring-experimental-cerebral-malaria-pathogenesis-through-the-characterisation-of-host-derived-plasma-microparticle-protein-content
#4
Natalia Tiberti, Sharissa L Latham, Stephen Bush, Amy Cohen, Robert O Opoka, Chandy C John, Annette Juillard, Georges E Grau, Valéry Combes
Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection responsible for thousands of deaths in children in sub-Saharan Africa. CM pathogenesis remains incompletely understood but a number of effectors have been proposed, including plasma microparticles (MP). MP numbers are increased in CM patients' circulation and, in the mouse model, they can be localised within inflamed vessels, suggesting their involvement in vascular damage. In the present work we define, for the first time, the protein cargo of MP during experimental cerebral malaria (ECM) with the overarching hypothesis that this characterisation could help understand CM pathogenesis...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904618/assessment-of-different-anesthesia-depth-under-total-intravenous-anesthesia-on-postoperative-cognitive-function-in-laparoscopic-patients
#5
Delin Zhang, Aiqing Nie
BACKGROUND: This study aimed to compare the effects of different depths of sedation during total intravenous anesthesia (TIVA) with remifentanil and propofol given by target-controlled infusion (TCI) on postoperative cognitive function in young and middle-aged patients undergoing gynecological laparoscopic surgery. MATERIALS AND METHODS: A total of 150 American Society of Anesthesiologists physical Status I/II patients scheduled for gynecological laparoscopic operation were randomly divided into three groups...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27901414/cognitive-deficits-and-inflammatory-response-resulting-from-mild-to-moderate-traumatic-brain-injury-in-rats-are-exacerbated-by-repeated-pre-exposure-to-an-innate-stress-stimulus
#6
Michaël Ogier, Amor Belmeguenai, Thomas Lieutaud, Béatrice Georges, Sandrine Bouvard, Emilie Carré, Frédéric Canini, Laurent Bezin
Traumatic brain injury (TBI) is common in both military and civilian populations, and often results in neurobehavioral sequelae that impair quality of life in both patients and their family. Although individuals who are chronically exposed to stress are more likely to experience TBI, it is still unknown whether pre-injury stress influences the outcome after TBI. The present study tested whether behavioral and cognitive long-term outcome after TBI in rats is affected by prior exposure to an innate stress stimulus...
November 30, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27895578/cognitive-performance-patterns-in-healthy-individuals-with-substantia-nigra-hyperechogenicity-and-early-parkinson-s-disease
#7
Rezzak Yilmaz, Susanne Gräber, Benjamin Roeben, Ulrike Suenkel, Anna-Katharina von Thaler, Sebastian Heinzel, Florian G Metzger, Gerhard W Eschweiler, Walter Maetzler, Daniela Berg, Inga Liepelt-Scarfone
Introduction: Hyperechogenicity of the substantia nigra (SN+) is a risk marker for Parkinson's disease (PD) which can be detected before the diagnosis. In healthy individuals, SN+ has been associated with slight deficits in specific cognitive functions, suggesting cognitive impairment as a possible pre-diagnostic marker for PD. However, the pattern of cognitive deficits associated with SN+ has not yet been compared with those present in PD. Methods: Data of 262 healthy individuals with normal echogenicity (SN-) and 48 healthy individuals with SN+ were compared with 82 early stage PD patients using the "Consortium to Establish a Registry for Alzheimer's disease" test battery...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27891114/comparative-analysis-of-two-helicobacter-pylori-strains-using-genomics-and-mass-spectrometry-based-proteomics
#8
Roger Karlsson, Kaisa Thorell, Shaghayegh Hosseini, Diarmuid Kenny, Carina Sihlbom, Åsa Sjöling, Anders Karlsson, Intawat Nookaew
Helicobacter pylori, a gastroenteric pathogen believed to have co-evolved with humans over 100,000 years, shows significant genetic variability. This motivates the study of different H. pylori strains and the diseases they cause in order to identify determinants for disease evolution. In this study, we used proteomics tools to compare two H. pylori strains. Nic25_A was isolated in Nicaragua from a patient with intestinal metaplasia, and P12 was isolated in Europe from a patient with duodenal ulcers. Differences in the abundance of surface proteins between the two strains were determined with two mass spectrometry-based methods, label-free quantification (MaxQuant) or the use of tandem mass tags (TMT)...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27890796/temporal-profiles-of-plasma-proteome-during-childhood-development
#9
Chih-Wei Liu, Lisa Bramer, Bobbie-Jo Webb-Robertson, Kathleen Waugh, Marian J Rewers, Qibin Zhang
Human blood plasma proteome reflects physiological changes associated with a child's development as well as development of disease states. While age-specific normative values are available for proteins routinely measured in clinical practice, there is paucity of comprehensive longitudinal data regarding changes in human plasma proteome during childhood. We applied TMT-10plex isobaric labeling-based quantitative proteomics to longitudinally profile the plasma proteome in 10 healthy children during their development, each with 9 serial time points from 9months to 15years of age...
November 23, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27886019/an-analysis-of-a-digital-variant-of-the-trail-making-test-using-machine-learning-techniques
#10
Jessamyn Dahmen, Diane Cook, Robert Fellows, Maureen Schmitter-Edgecombe
BACKGROUND: The goal of this work is to develop a digital version of a standard cognitive assessment, the Trail Making Test (TMT), and assess its utility. OBJECTIVE: This paper introduces a novel digital version of the TMT and introduces a machine learning based approach to assess its capabilities. METHODS: Using digital Trail Making Test (dTMT) data collected from (N = 54) older adult participants as feature sets, we use machine learning techniques to analyze the utility of the dTMT and evaluate the insights provided by the digital features...
November 18, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/27884145/estimation-of-the-cool-executive-function-using-frontal-electroencephalogram-signals-in-first-episode-schizophrenia-patients
#11
Yi Yu, Yun Zhao, Yajing Si, Qiongqiong Ren, Wu Ren, Changqin Jing, Hongxing Zhang
BACKGROUND: In schizophrenia, executive dysfunction is the most critical cognitive impairment, and is associated with abnormal neural activities, especially in the frontal lobes. Complexity estimation using electroencephalogram (EEG) recording based on nonlinear dynamics and task performance tests have been widely used to estimate executive dysfunction in schizophrenia. METHODS: The present study estimated the cool executive function based on fractal dimension (FD) values of EEG data recorded from first-episode schizophrenia patients and healthy controls during the performance of three cool executive function tasks, namely, the Trail Making Test-A (TMT-A), Trail Making Test-B (TMT-B), and Tower of Hanoi tasks...
November 25, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/27880834/overexpressed-proteins-in-hypervirulent-clade-8-and-clade-6-strains-of-escherichia-coli-o157-h7-compared-to-e-coli-o157-h7-edl933-clade-3-strain
#12
Natalia Amigo, Qi Zhang, Ariel Amadio, Qunjie Zhang, Wanderson M Silva, Baiyuan Cui, Zhongjian Chen, Mariano Larzabal, Jinlong Bei, Angel Cataldi
Escherichia coli O157:H7 is responsible for severe diarrhea and hemolytic uremic syndrome (HUS), and predominantly affects children under 5 years. The major virulence traits are Shiga toxins, necessary to develop HUS and the Type III Secretion System (T3SS) through which bacteria translocate effector proteins directly into the host cell. By SNPs typing, E. coli O157:H7 was separated into nine different clades. Clade 8 and clade 6 strains were more frequently associated with severe disease and HUS. In this study, we aimed to identify differentially expressed proteins in two strains of E...
2016: PloS One
https://www.readbyqxmd.com/read/27874176/effects-of-tai-chi-on-cognition-and-fall-risk-in-older-adults-with-mild-cognitive-impairment-a-randomized-controlled-trial
#13
Somporn Sungkarat, Sirinun Boripuntakul, Nipon Chattipakorn, Kanokwan Watcharasaksilp, Stephen R Lord
OBJECTIVES: To examine whether combined center- and home-based Tai Chi training can improve cognitive ability and reduce physiological fall risk in older adults with amnestic mild cognitive impairment (a-MCI). DESIGN: Randomized controlled trial. SETTING: Chiang Mai, Thailand. PARTICIPANTS: Adults aged 60 and older who met Petersen's criteria for multiple-domain a-MCI (N = 66). INTERVENTION: Three weeks center-based and 12 weeks home-based Tai Chi (50 minutes per session, 3 times per week)...
November 22, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27869715/randomized-prospective-double-blind-studies-to-evaluate-the-cognitive-effects-of-inositol-stabilized-arginine-silicate-in-healthy-physically-active-adults
#14
Douglas Kalman, Philip D Harvey, Sara Perez Ojalvo, James Komorowski
Inositol-stabilized arginine silicate (ASI; Nitrosigine(®)) has been validated to increase levels of arginine, silicon and nitric oxide production. To evaluate potential enhancement of mental focus and clarity, ASI (1500 mg/day) was tested in two double-blind placebo-controlled crossover (DBPC-X) studies using the Trail Making Test (TMT, Parts A and B). In the two studies, healthy males took ASI for 14 and 3 days, respectively. In the first study, after 14 days of dosing, TMT B time decreased significantly from baseline (28% improvement, p = 0...
November 18, 2016: Nutrients
https://www.readbyqxmd.com/read/27868580/attention-lapses-in-children-with-spina-bifida-and-hydrocephalus-and-children-with-attention-deficit-hyperactivity-disorder
#15
Gabriel G De la Torre, Alba Martin, Elizabeth Cervantes, Rocio Guil, Jose M Mestre
Attentional lapses are usually defined as temporary and often brief shifts of attention away from some primary task to unrelated internal information processing. This study addressed the incidence of attention lapses and differences in attentional functioning in 30 children with attention-deficit/hyperactivity disorder (ADHD), 26 healthy children, and 29 children with spina bifida myelomeningocele and hydrocephalus (SBH). Assessments were conducted using computerized tonic and phasic attention tests, the Symbol Digit Modalities Test (SDMT), and the Trail Making Test Form B (TMT-B)...
November 20, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27861563/binge-drinking-in-young-university-students-is-associated-with-alterations-in-executive-functions-related-to-their-starting-age
#16
Diana Salas-Gomez, Mario Fernandez-Gorgojo, Ana Pozueta, Isabel Diaz-Ceballos, Maider Lamarain, Carmen Perez, Pascual Sanchez-Juan
Our aim was to evaluate whether or not alcohol consumption in the form of binge drinking is associated with alterations of memory and executive functions in a population of university students. At the same time, we have studied the role of potential modulating factors, such as the APOE genotype or physical exercise.University students enrolled in academic year 2013-2014 at Escuelas Universitarias Gimbernat-Cantabria, affiliated with the University of Cantabria, were invited to participate in the study. We gathered sociodemographic data and details regarding the lifestyle of 206 students (mean age 19...
2016: PloS One
https://www.readbyqxmd.com/read/27861495/two-opsin-3-related-proteins-in-the-chicken-retina-and-brain-a-tmt-type-opsin-3-is-a-blue-light-sensor-in-retinal-horizontal-cells-hypothalamus-and-cerebellum
#17
Mutsuko Kato, Takashi Sugiyama, Kazumi Sakai, Takahiro Yamashita, Hirofumi Fujita, Keita Sato, Sayuri Tomonari, Yoshinori Shichida, Hideyo Ohuchi
Opsin family genes encode G protein-coupled seven-transmembrane proteins that bind a retinaldehyde chromophore in photoreception. Here, we sought potential as yet undescribed avian retinal photoreceptors, focusing on Opsin 3 homologs in the chicken. We found two Opsin 3-related genes in the chicken genome: one corresponding to encephalopsin/panopsin (Opn3) in mammals, and the other belonging to the teleost multiple tissue opsin (TMT) 2 group. Bioluminescence imaging and G protein activation assays demonstrated that the chicken TMT opsin (cTMT) functions as a blue light sensor when forced-expressed in mammalian cultured cells...
2016: PloS One
https://www.readbyqxmd.com/read/27860400/identification-of-protein-changes-in-human-spermatozoa-throughout-the-cryopreservation-process
#18
O A Bogle, K Kumar, C Attardo-Parrinello, S E M Lewis, J M Estanyol, J L Ballescà, R Oliva
Cryoinjury is a consequence of cryopreservation and may have a negative impact on sperm quality regarding motility, morphology, and viability. This study was designed to identify potential proteomic changes in human sperm cells throughout the cryopreservation process. Comparisons made within this study included the detection of the sperm proteomic changes induced by incubation of the sperm cells with a protein-free cryoprotectant (with and without CryoSperm), and the proteomic changes induced by freezing, thawing, and subsequent after-thawing incubation at two different temperatures (0 °C vs...
November 17, 2016: Andrology
https://www.readbyqxmd.com/read/27855415/instrumented-trail-making-task-to-differentiate-persons-with-no-cognitive-impairment-amnestic-mild-cognitive-impairment-and-alzheimer-disease-a-proof-of-concept-study
#19
He Zhou, Marwan Sabbagh, Rachel Wyman, Carolyn Liebsack, Mark E Kunik, Bijan Najafi
BACKGROUND: Objective and time-effective tools are needed to identify motor-cognitive impairment and facilitate early intervention. OBJECTIVE: We examined the feasibility, accuracy, and reliability of an instrumented trail-making task (iTMT) using a wearable sensor to identify motor-cognitive impairment among older adults. METHODS: Thirty subjects (age = 82.2 + 6.1 years, body mass index = 25.7 + 4.8, female = 43.3%) in 3 age-matched groups, 11 healthy, 10 with amnestic mild cognitive impairment (aMCI), and 9 with Alzheimer disease (AD), were recruited...
November 18, 2016: Gerontology
https://www.readbyqxmd.com/read/27853742/psychomotor-and-cognitive-effects-of-15-minute-inhalation-of-methoxyflurane-in-healthy-volunteers-implication-for-post-colonoscopy-care
#20
Nam Q Nguyen, Jenna Burgess, Tamara L Debreceni, Leanne Toscano
Background and study aims: Colonoscopy with portal inhaled methoxyflurane (Penthrox) is highly feasible with low sedation risk and allows earlier discharge. It is unclear if subjects can return to highly skilled psychomotor skill task shortly after Penthrox assisted colonoscopy. We evaluated the psychomotor and cognitive effects of 15-minute inhalation of Penthrox in adults. Patients and methods: Sixty healthy volunteers (18 to 80 years) were studied on 2 occasions with either Penthrox or placebo in a randomized, double-blind fashion...
November 2016: Endoscopy International Open
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