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https://www.readbyqxmd.com/read/28070585/effect-of-proline-on-biochemical-and-molecular-mechanisms-in-lettuce-lactuca-sativa-l-exposed-to-uv-b-radiation
#1
Ozkan Aksakal, Dilruba Tabay, Aslıhan Esringu, Feyza Icoglu Aksakal, Nevzat Esim
The purpose of the present study was to evaluate the role of proline (Pro) in relieving UV-B radiation-induced oxidative stress in lettuce. Lettuce seedlings were exposed to 3.3 W m(-2) UV-B radiation for 12 h after pre-treatment sprayed with 20 mM Pro. The data for malondialdehyde (MDA), hydrogen peroxide (H2O2), endogenous Pro level, the activities of antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), and peroxidase (POD)], total phenolic concentration, antioxidant capacity, expression of phenylalanine ammonia lyase (PAL), γ-tocopherol methyltransferase (γ-TMT) and proline dehydrogenase (ProDH) genes, phytohormone levels such as abscisic acid (ABA), gibberellic acid (GA), indole acetic acid (IAA) and salicylic acid (SA), soluble sugars and organic acids were recorded...
January 10, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28068937/the-efficacy-and-roles-of-combining-temozolomide-with-whole-brain-radiotherapy-in-protection-neurocognitive-function-and-improvement-quality-of-life-of-non-small-cell-lung-cancer-patients-with-brain-metastases
#2
Xia Deng, Zhen Zheng, Baochai Lin, Huafang Su, Hanbin Chen, Shaoran Fei, Zhenghua Fei, Lihao Zhao, Xiance Jin, Cong-Ying Xie
BACKGROUND: Brain metastasis (BM) is a poor prognostic factor for non-small-cell lung cancer (NSCLC). The efficacy and roles of combining temozolomide (TMZ) with whole brain radiotherapy (WBRT) in protection neurocognitive function (NCF) and improvement quality of life (QOL) were investigated and compared with WBRT alone in the treatment of NSCLC patients with BM. METHODS: A total of 238 NSCLC patients with BM were reviewed and categorized into WBRT plus TMZ (RCT) arm and WBRT alone (RT), respectively...
January 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28068416/growth-enhanced-transgenic-coho-salmon-oncorhynchus-kisutch-strains-have-varied-success-in-simulated-streams-implications-for-risk-assessment
#3
Rosalind A Leggatt, L Fredrik Sundström, Krista Woodward, Robert H Devlin
Growth hormone (GH) transgenic fish have accelerated growth and could improve production efficiency in aquaculture. However, concern exists regarding potential environmental risks of GH transgenic fish should they escape rearing facilities. While environmental effects have been examined in some GH transgenic models, there is a lack of information on whether effects differ among different constructs or strains of transgenic fish. We compared growth and survival of wild-type coho salmon (Oncorhynchus kisutch) fry, a fast-growing GH transgenic strain containing a metallothionein promoter (TMT), and three lines/strains containing a reportedly weaker histone-3 promoter (TH3) in hatchery conditions and semi-natural stream tanks with varying levels of natural food and predators...
2017: PloS One
https://www.readbyqxmd.com/read/28063392/differences-in-the-verbal-fluency-working-memory-and-executive-functions-in-alcoholics-short-term-vs-long-term-abstainers
#4
Katarzyna Nowakowska-Domagała, Karolina Jabłkowska-Górecka, Łukasz Mokros, Jacek Koprowicz, Tadeusz Pietras
The aim of the study was to assess differences in verbal fluency, working memory and executive functions in two subgroups of alcohol-dependent patients, those undergoing short-term abstinence (STA) and those undergoing long-term abstinence (LTA), and to compare the level of cognitive functions in patients after long-term abstinence with healthy subjects. The study group consisted of 106 alcohol-dependent patients (53 immediately after drinking at least 3 days and 53 after at least one-year abstinence). The control group comprised 53 subjects, whose age, sex and education levels matched those of the patients in the experimental group...
December 27, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28061865/proteomic-analysis-of-enterotoxigenic-escherichia-coli-etec-in-neutral-and-alkaline-conditions
#5
Lucia Gonzales-Siles, Roger Karlsson, Diarmuid Kenny, Anders Karlsson, Åsa Sjöling
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in children and travelers to endemic areas. Secretion of the heat labile AB5 toxin (LT) is induced by alkaline conditions. In this study, we determined the surface proteome of ETEC exposed to alkaline conditions (pH 9) as compared to neutral conditions (pH 7) using a LPI Hexalane FlowCell combined with quantitative proteomics. Relative quantitation with isobaric labeling (TMT) was used to compare peptide abundance and their corresponding proteins in multiple samples at MS/MS level...
January 7, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28056988/cytoreductive-nephrectomy-with-thrombectomy-before-targeted-therapy-improves-survival-for-metastatic-renal-cell-carcinoma-with-venous-tumor-thrombus-a-single-center-experience
#6
Nienie Qi, Pengjie Wu, Jinchao Chen, Teng Li, Xianghui Ning, Jin Wang, Kan Gong
BACKGROUND: The aim of the study is to evaluate the role of cytoreductive nephrectomy (CN) with thrombectomy before targeted molecular therapy (TMT) on survival in metastatic renal cell carcinoma (mRCC) with venous tumor thrombus. METHODS: We performed a retrospective analysis of 47 patients treated in our center from April 2008 to October 2014. In the study, 20 patients underwent CN with thrombectomy followed by targeted therapy (group 1); 15 patients received targeted therapy alone (group 2); and 12 patients underwent CN with thrombectomy alone (group 3)...
January 5, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28053894/effect-of-yoga-program-on-executive-functions-of-adolescents-dwelling-in-an-orphan-home-a-randomized-controlled-study
#7
Satya Prakash Purohit, Balaram Pradhan
Executive function (EF) is important for physical and mental health of children. Studies have shown that children with poverty and early life stress have reduced EF. The aim of the study was to evaluate the effect of Yoga program on the EF of orphan adolescents. Seventy two apparently healthy orphan adolescents randomized and allocated into two groups as Yoga group (n = 40; 14 girls, age = 12.69 ± 1.35 yrs) and Wait List Control (WLC) group (n = 32, 13 girls, age = 12.58 ± 1.52 yrs). Yoga group underwent three months of Yoga program in a schedule of 90 min per day, four days per week whereas the WLC group followed the routine activities...
January 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28050694/survival-prediction-using-temporal-muscle-thickness-measurements-on-cranial-magnetic-resonance-images-in-patients-with-newly-diagnosed-brain-metastases
#8
Julia Furtner, Anna S Berghoff, Omar M Albtoush, Ramona Woitek, Ulrika Asenbaum, Daniela Prayer, Georg Widhalm, Brigitte Gatterbauer, Karin Dieckmann, Peter Birner, Bernadette Aretin, Rupert Bartsch, Christoph C Zielinski, Veronika Schöpf, Matthias Preusser
OBJECTIVES: To evaluate the prognostic relevance of temporal muscle thickness (TMT) in brain metastasis patients. METHODS: We retrospectively analysed TMT on magnetic resonance (MR) images at diagnosis of brain metastasis in two independent cohorts of 188 breast cancer (BC) and 247 non-small cell lung cancer (NSCLC) patients (overall: 435 patients). RESULTS: Survival analysis using a Cox regression model showed a reduced risk of death by 19% with every additional millimetre of baseline TMT in the BC cohort and by 24% in the NSCLC cohort...
January 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28040351/clinical-outcomes-of-patients-with-histologic-variants-of-urothelial-cancer-treated-with-trimodality-bladder-sparing-therapy
#9
Ross E Krasnow, Michael Drumm, Hannah J Roberts, Andrzej Niemierko, Chin-Lee Wu, Shulin Wu, Jing Zhang, Niall M Heney, Matthew F Wszolek, Michael L Blute, Adam S Feldman, Richard J Lee, Anthony L Zietman, William U Shipley, Jason A Efstathiou
BACKGROUND: Trimodality bladder-sparing therapy (TMT) is an acceptable treatment for selected patients with muscle-invasive urothelial cancer. Outcomes of TMT in histologic variants remains largely unknown. OBJECTIVE: To compare outcomes of pure urothelial carcinoma (PUC) to variant urothelial carcinoma (VUC) after TMT. DESIGN, SETTING, AND PARTICIPANTS: Retrospective study of patients treated with TMT at a single cancer center from 1993 until 2013...
December 28, 2016: European Urology
https://www.readbyqxmd.com/read/28033546/alterations-in-balance-and-mobility-in-people-with-epilepsy
#10
Carlos R Camara-Lemarroy, Daniela Ortiz-Zacarías, Juan J Peña-Avendaño, Ingrid Estrada-Bellmann, Héctor J Villarreal-Velázquez, Marco A Díaz-Torres
PURPOSE: People with epilepsy (PWE) are burdened by physical disability and side effects of antiepileptic drugs (AED) such as drowsiness and blurred vision. These factors place them at risk for reduced mobility and falls. The purpose of this study was to evaluate mobility and balance in PWE. METHODS: This was a cross-sectional study of PWE and age- and sex-matched controls. We evaluated mobility and balance using the Timed Up and Go Test (TUG) and the Tinetti Mobility Test (TMT)...
December 26, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28030612/distinct-and-shared-endophenotypes-of-neural-substrates-in-bipolar-and-major-depressive-disorders
#11
Toshio Matsubara, Koji Matsuo, Kenichiro Harada, Masayuki Nakano, Mami Nakashima, Toshio Watanuki, Kazuteru Egashira, Matakazu Furukawa, Naofumi Matsunaga, Yoshifumi Watanabe
Little is known about disorder-specific biomarkers of bipolar disorder (BD) and major depressive disorder (MDD). Our aim was to determine a neural substrate that could be used to distinguish BD from MDD. Our study included a BD group (10 patients with BD, 10 first-degree relatives (FDRs) of individuals with BD), MDD group (17 patients with MDD, 17 FDRs of individuals with MDD), and 27 healthy individuals. Structural and functional brain abnormalities were evaluated by voxel-based morphometry and a trail making test (TMT), respectively...
2016: PloS One
https://www.readbyqxmd.com/read/28006786/neuropsychological-outcome-in-subthalamic-nucleus-stimulation-surgeries-with-electrodes-passing-through-the-caudate-nucleus
#12
Cihan Isler, Angela Albi, Frédéric L W V J Schaper, Yasin Temel, Annelien Duits
BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson disease (PD) is associated with postoperative cognitive decline. One of the proposed underlying mechanisms is the surgical procedure with the lead trajectory penetrating the caudate nucleus. OBJECTIVE: To study whether penetration of the caudate nucleus affects neuropsychological outcome. METHODS: Neuropsychological and imaging data of 30 PD patients who underwent bilateral STN DBS were analysed...
December 23, 2016: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28003570/correlations-between-cognitive-impairments-and-employment-status-in-patients-with-diffuse-axonal-injury
#13
Shin Hirota, Motoki Inaji, Tadashi Nariai, Mutsuya Hara, Masashi Tamaki, Taketoshi Maehara, Hiroki Tomita, Osamu Tone
Patients with diffuse axonal injury (DAI) may initially present with prominent physical impairments, but their cognitive dysfunctions are more persistent and are attributable to later unemployment. In this study, we analyzed how the findings of early and delayed neuropsychological assessments correlated with employment outcome of patients with DAI. A total of 56 patients with DAI without motor or visual dysfunction were included in this study. The neuropsychological battery consisted of the Wechsler Adult Intelligent Scale - Revised (WAIS-R), Wechsler Memory Scale - Revised (WMS-R), Trail Making Test (TMT), Wisconsin Card Sorting Test (WCST), and Word Fluency Test (WFT)...
December 22, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27996218/association-of-early-physical-activity-time-with-pain-activities-of-daily-living-and-progression-of-vertebral-body-collapse-in-patients-with-vertebral-compression-fractures-an-observational-study-at-single-institution
#14
Hideki Kataoka, Tatsunori Ikemoto, Ayana Yoshimura, Mihoko Shibuya, Kyo Goto, Jyunichirou Yamashita, Kaoru Morita, Jyunya Sakamoto, Jiro Nakano, Minoru Okita
BACKGROUND: Physical activity can reduce pain and improve the ability to perform daily activities in patients with acute low back pain (LBP) due to various non-specific causes. The association between physical activity during the early phase of acute vertebral compression fractures (VCFs) and rehabilitation outcomes is unknown. AIM: To investigate the effects of early physical activity time (EPAT) on pain following acute VCFs, recovery of the ability to perform activities of daily living (ADLs), and progression of fractured vertebral body collapse...
December 19, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27990134/allocentric-spatial-memory-testing-predicts-conversion-from-mild-cognitive-impairment-to-dementia-an-initial-proof-of-concept-study
#15
Ruth A Wood, Kuven K Moodley, Colin Lever, Ludovico Minati, Dennis Chan
The hippocampus is one of the first regions to exhibit neurodegeneration in Alzheimer's disease (AD), and knowledge of its role in allocentric spatial memory may therefore aid early diagnosis of AD. The 4 Mountains Test (4MT) is a short and easily administered test of spatial memory based on the cognitive map theory of hippocampal function as derived from rodent single cell and behavioral studies. The 4MT has been shown in previous cross-sectional studies to be sensitive and specific for mild cognitive impairment (MCI) due to AD...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27981543/cognitive-impairment-and-quality-of-life-in-patients-with-migraine-associated-vertigo
#16
N Wang, H-L Huang, H Zhou, C-Y Yu
OBJECTIVE: To study the impact of migraine-associated vertigo (MV) on the cognitive state of patients and their quality of life. PATIENTS AND METHODS: A total of 120 patients were enrolled in the study, including 40 diagnosed with MV, forty with a simple migraine and 40 healthy volunteers. Cognitive assessments were done using the mini-mental state examination (MMSE), and a battery of tests for cognitive functions in performance, memory, language, space and attention during interictal periods...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27978624/neutral-loss-is-a-very-common-occurrence-in-phosphotyrosine-containing-peptides-labeled-with-isobaric-tags
#17
Robert A Everley, Edward L Huttlin, Alison R Erickson, Sean A Beausoleil, Steven P Gygi
While developing a multiplexed phosphotyrosine peptide quantification assay, an unexpected observation was made: significant neutral loss from phosphotyrosine (pY) containing peptides. Using a 2000-member peptide library, we sought to systematically investigate this observation by comparing unlabeled peptides with the two highest-plex isobaric tags (iTRAQ8 and TMT10) across CID, HCD, and ETD fragmentation using high resolution high mass accuracy Orbitrap instrumentation. We found pY peptide neutral loss behavior was consistent with reduced proton mobility, and does not occur during ETD...
December 30, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27975283/tmt-one-stop-shop-from-reliable-sample-preparation-to-computational-analysis-platform
#18
Mehdi Mirzaei, Dana Pascovici, Jemma X Wu, Joel Chick, Yunqi Wu, Brett Cooke, Paul Haynes, Mark P Molloy
In this chapter we describe the workflow we use for labeled quantitative proteomics analysis using tandem mass tags (TMT) starting with the sample preparation and ending with the multivariate analysis of the resulting data. We detail the step-by-step process from sample processing, labeling, fractionation, and data processing using Proteome Discoverer through to data analysis and interpretation in the context of a multi-run experiment. The final analysis and data interpretation rely on an R package we call TMTPrepPro, which are deployed on a local GenePattern server, and used for generating various outputs which are also outlined herein...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27960280/identification-of-a-genetic-factor-required-for-high-%C3%AE-isoform-concentration-in-rice-vitamin-e
#19
Daisuke Sekine, Kazumasa Murata, Toshiyuki Kimura, Kiyotaka Nakagawa, Teruo Miyazawa
The γ-isoforms of tocopherols (Tc) and tocotrienols (T3) possess high biological activities in comparison to the α-isoforms. The concentrations of Tc and T3 isoforms in rice (Oriza sativa) was cultivar-dependent. Using chromosome segment substitution lines (CSSLs) and near isogenic lines (NILs) of indica cultivar "Kasalath" in a japonica cultivar "Koshihikari" genetic background, the Kasalath genomic segment on chromosome 2 was determined to be responsible for the high γ-isoform concentration: γ-tocopherol methyltransferase (γ-TMT) was identified as a candidate gene...
December 14, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27951519/differential-cytokine-levels-between-early-withdrawal-and-remission-states-in-patients-with-alcohol-dependence
#20
Che-Hung Yen, Pei-Shen Ho, Yi-Wei Yeh, Chih-Sung Liang, Shin-Chang Kuo, Chang-Chih Huang, Chun-Yen Chen, Mei-Chen Shih, Kuo-Hsing Ma, Yueh-Feng Sung, Ru-Band Lu, San-Yuan Huang
Alcohol dependence (AD) leads to altered innate and adaptive immune responses, and frequently co-occurs with inflammation. Therefore, inflammatory cytokines potentially play a crucial role in the development of alcohol-related illnesses. This study evaluated changes in plasma cytokine concentrations, liver function, cravings, depression severity, and cognitive function in male patients with AD, during the course of an alcohol-detoxification program. A total of 78 male patients with AD were recruited for a conservative detoxification program; and cytokine levels, depressive score, and cognitive impairment applying the Trail Making Test (TMT) were evaluated during early withdrawal (baseline) and after 4 weeks of abstinence from alcohol...
October 20, 2016: Psychoneuroendocrinology
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