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Beta Glucans

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https://www.readbyqxmd.com/read/28756506/high-and-low-molecular-weight-oat-beta-glucan-reveals-antitumor-activity-in-human-epithelial-lung-cancer
#1
Anna Choromanska, Julita Kulbacka, Joanna Harasym, Remigiusz Oledzki, Anna Szewczyk, Jolanta Saczko
Beta-glucans are widely used in treatment, cosmetics, and the food industry. Glucans play a significant role in activation of the immune and antioxidant system and inhibiting tumor proliferation. In the current study the antitumor activities of new high and low molecular weight beta-glucan derived from oats were investigated in two human lung cancer cell line (A549, H69AR) and normal keratinocytes (HaCaT). The effect of high and low molecular weight beta-glucan from oat was evaluated by cellular viability assessment, lipid peroxidation and manganese superoxide dismutase evaluation and cytoskeleton visualisation...
July 29, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28729759/transcriptome-wide-identification-and-characterization-of-starch-branching-enzyme-in-finger-millet
#2
Rajhans Tyagi, Apoorv Tiwari, Vijay Kumar Garg, Sanjay Gupta
Starch-branching enzymes (SBEs) are one of the four major enzyme classes involved in starch biosynthesis in plants and play an important role in determining the structure and physical properties of starch granules. Multiple SBEs are involved in starch biosynthesis in plants. Finger millet is calcium rich important serial crop belongs to grass family and the transcriptome data of developing spikes is available on NCBI. In this study it was try to find out the gene sequence of starch branching enzyme and annotate the sequence and submit the sequence for further use...
2017: Bioinformation
https://www.readbyqxmd.com/read/28724171/beta-glucan-inositol-and-digestive-enzymes-improve-quality-of-life-of-patients-with-inflammatory-bowel-disease-and-irritable-bowel-syndrome
#3
R Spagnuolo, C Cosco, R M Mancina, G Ruggiero, P Garieri, V Cosco, P Doldo
OBJECTIVE: To evaluate the efficacy of a mixture of beta-glucan, inositol and digestive enzymes in improving gastrointestinal symptoms in patients affected by inflammatory bowel disease (IBD)-irritable bowel syndrome (IBS). PATIENTS AND METHODS: The study was conducted at the IBD Unit of the University of Catanzaro. Forty-three IBD patients with IBS symptoms were included in the study. IBD diagnosis was performed by clinical, endoscopic, histological and radiological criteria...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28675291/efficacy-of-carboxymethyl-beta-glucan-in-cervical-intraepithelial-neoplasia-a-retrospective-case-control-study
#4
Patrizia Stentella, Alberto Biamonti, Carlo Carraro, Paolo Inghirami, Pasquale Mancino, Daniela Pietrangeli, Sergio Votano, Paola Lazzari, Caterina DE Medici
BACKGROUND: Persistent human papillomavirus (HPV) infection constitutes the principal risk factor for the development of cervical intraepithelial neoplasia (CIN) and cervical cancer. For this reason, new drugs have been studied to support the host immune system against the HPV infection. The aim of this retrospective, case-control study was to detect the efficacy and safety of carboxymethyl β-glucan (Colpofix®) gel as adjuvant therapy in HPV infection. METHODS: The medical records of patients attending the Colposcopy Service of four hospitals in Rome from 2011 to 2013 were collected...
October 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28674449/dexamethasone-induced-inhibition-of-dectin-1-activation-of-antigen-presenting-cells-is-mediated-via-stat-3-and-nf-%C3%AE%C2%BAb-signaling-pathways
#5
Philipp Kotthoff, Annkristin Heine, Stefanie Andrea Erika Held, Peter Brossart
Treatment of patients with glucocorticoids can result in an increased risk of infection with pathogens such as fungi. Dectin-1 is a member of the C-type lectin receptor superfamily and was shown to be one of the major receptors for fungal beta-glucans. Activation of Dectin-1 increases the production of cytokines and chemokines and T-cell stimulatory capacity of DC and mediates resolution of fungal infections. Here we show that antigen-presenting cells generated in the presence of dexamethasone (Dex-DC) have a reduced capacity to stimulate T-cell proliferation and decreased expression of costimulatory molecules, that can not be enhanced upon stimulation with Dectin-1 ligands...
July 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28672109/effect-of-barley-%C3%AE-glucan-on-the-gluten-polymerization-process-in-dough-during-heat-treatment
#6
Ze-Hua Huang, Yang Zhao, Ke-Xue Zhu, Xiao-Na Guo, Wei Peng, Hui-Ming Zhou
Barley (Hordeum vulgare L.) β-glucan (BBG) is of interest as a result of its health benefits, but BBG presents significant disruptions on the gluten network, with a negative impact on food texture. To clarify the interaction between BBG and gluten in dough, the dynamic rheological, thermochemical process of gluten and microstructure of dough with BBG during heating were detected. The results showed that BBG delayed the gluten thermopolymerization reaction during heating and affected polymerization of specific molecular weight protein subunits...
July 26, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28659321/performance-of-a-quantitative-pcr-based-assay-and-beta-d-glucan-detection-for-the-diagnosis-of-invasive-candidiasis-in-very-low-birth-weight-preterm-neonatal-patients-candineo-study
#7
Jose Tomas Ramos, Sonia Villar, Emilio Bouza, Elena Bergon-Sendin, Alfredo Perez Rivilla, Caridad Tapia Collados, Mariano Andreu, Candelaria Santana Reyes, María Isolina Campos-Herrero, Jon López de Heredia, María Cruz López Herrera, Paloma Anguita Alonso, Carmen Rosa Pallás-Alonso, Manuel Cuenca-Estrella
An epidemiological, multicenter, non-interventional, observational case-control study was conducted to describe the performance of serum Beta-D-Glucan (BDG) and Candida polymerase chain reaction (PCR) in blood, serum and sterile samples for the diagnosis of invasive candidiasis (IC) in very low birth weight (VLBW) preterm neonates, and to compare these techniques with cultures from blood and other sterile sites. Seventeen centers participated in the study and the number of episodes analyzed was 159. A total of nine episodes of IC from nine patients (seven confirmed and two probable) and 150 episodes of suspected sepsis from 117 controls were identified...
June 28, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28655067/fatal-ulcerative-enteritis-of-the-small-intestine-in-a-patient-with-ulcerative-colitis-treated-with-vedolizumab
#8
Carmen Monasterio, Annette Schmitt-Gräff, Matthias Pohl, Thomas Truschel, Klaus Warnatz, Wolfgang Kreisel, Robert Thimme, Peter Hasselblatt
Vedolizumab (VDZ) inhibits α4β7 integrins and is used to target intestinal immune responses in patients with inflammatory bowel disease, which is considered to be relatively safe. Here we report on a fatal complication following VDZ administration. A 64-year-old female patient with ulcerative colitis (UC) refractory to tumor necrosis factor inhibitors was treated with VDZ. One week after the second VDZ infusion, she was admitted to hospital with severe diarrhea and systemic inflammatory response syndrome (SIRS)...
June 27, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28645493/sprayable-carbopol-hydrogel-with-soluble-beta-1-3-1-6-glucan-as-an-active-ingredient-for-wound-healing-development-and-in-vivo-evaluation
#9
Jostein Grip, Rolf Einar Engstad, Ingrid Skjæveland, Nataša Škalko-Basnet, Ann Mari Holsæter
Chronic wounds represent a significant health problem worldwide. There is a need for advanced- and cost-efficient wound healing products able to increase patient comfort and reduce the healing time. The aim of this study was to develop a sprayable hydrogel dressing with beta-glucan (βG) as the active ingredient, targeting future application in the treatment of both chronic and burn wounds. The βG was chosen as an active ingredient because of its promising wound healing capabilities, whereas Carbopol 971P NF (Carbopol) was chosen as the thickening agent in the formulation due to several attractive characteristics such as its low viscosity, low toxicity, high transparency and good ion tolerance...
June 21, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28623531/elevated-serum-beta-d-glucan-with-pseudomonas-aspergillus-and-a-partially-acid-fast-organism-in-respiratory-cultures-a-case-of-hickam-s-dictum-over-occam-s-razor
#10
Salman Khan, Camille Hamula, Meenakshi Rana, Timothy Sullivan, Dallas Dunn, Pinki Patel, Aaron Mishkin, Shirish Huprikar
We describe a case of a man with ectopic Cushing's syndrome, elevated serum beta-D-glucan, and respiratory cultures with Pseudomonas, Aspergillus, and a partially acid-fast organism. Our case highlights challenges in diagnosis and management of coinfection in an immunocompromised host.
June 16, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28620550/generation-of-recombinant-antibodies-against-the-beta-1-6-branched-beta-1-3-d-glucan-schizophyllan-from-immunized-mice-via-phage-display
#11
Jörn Josewski, Sabine Buchmeier, André Frenzel, Philip Tinnefeld, Stefan Dübel, Udo Rau
beta-(1,6)-Branched beta-(1,3)-D-glucans like schizophyllan from the basidiomycete Schizophyllum commune excite various immunostimulatory effects and have been clinically tested as adjuvants. Some of the glucans are also applicable in food or petrol industry due to their viscosity and temperature stability in aqueous solution. Antibodies against these glucans could be used as tool for analysis of glucan preparations or for further research of its bioactivity. Therefore, an immune phage display library was constructed from mice immunized with schizophyllan...
2017: Biotechnology Research International
https://www.readbyqxmd.com/read/28594435/texture-and-lubrication-properties-of-functional-cream-cheese-effect-of-beta-glucan-and-phytosterol
#12
Dian Widya Ningtyas, Bhesh Bhandari, Nidhi Bansal, Sangeeta Prakash
The effect of β-glucan (BG) and phytosterols (PS) as fat replacers on textural, microstructural and lubrication properties of reduced-fat cream cheese was investigated. Five formulations (BG-PS ester, PS ester, BG-PS emulsions, PS emulsions, and BG) of cream cheese with added β-glucan and phytosterols (in emulsified and esterified form) were investigated and compared with commercial cheese. Among the five formulations used in this experiment, the effect of β-glucan appeared to be more pronounced imparting increased viscosity and firmness to reduced-fat cream cheese, similar to commercial high-fat cream cheese sample...
June 8, 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28593831/osmoregulated-periplasmic-glucans
#13
Sébastien Bontemps-Gallo, Jean-Pierre Bohin, Jean-Marie Lacroix
Among all the systems developed by enterobacteria to face osmotic stress, only osmoregulated periplasmic glucans (OPGs) were found to be modulated during osmotic fluxes. First detected in 1973 by E.P. Kennedy's group in a study of phospholipid turnover in Escherichia coli, OPGs have been shown across alpha, beta, and gamma subdivisions of the proteobacteria. Discovery of OPG-like compounds in the epsilon subdivision strongly suggested that the presence of periplasmic glucans is essential for almost all proteobacteria...
June 2017: EcoSal Plus
https://www.readbyqxmd.com/read/28584989/beta-glucan-particles-as-vaccine-adjuvant-carriers
#14
Zeynep Mirza, Ernesto R Soto, Fusun Dikengil, Stuart M Levitz, Gary R Ostroff
Glucan particles (GPs) are spherical hollow particles derived from Saccharomyces cerevisiae cell walls and mainly consist of β-1, 3-D-glucans. The inner hollow cavity of glucan particles can be loaded with different compounds, including protein antigens, and delivered to macrophages and dendritic cells. Moreover, the GP delivery system possesses β-glucan's intrinsic immunostimulatory properties. Therefore, GPs serve as both an antigen-presenting cell-targeted delivery system and an adjuvant.Here, we describe the production of GPs from S...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28566660/a-giant-dermatophyte-abscess-caused-by-trichophyton-rubrum-in-an-immunocompromised-patient
#15
Maiko Toyoki, Midori Hase, Yusuke Hirasawa, Takashi Umeyama, Yoshitsugu Miyazaki, Rui Kano, Takashi Sugita, Masataro Hiruma, Yuzo Kodama, Shigaku Ikeda
A 73-year-old male who had been receiving immunosuppressive drugs for 15 years developed a nodule on the left buttock region. The nodule slowly grew into a 15-cm fluctuant multilocular subcutaneous cyst. Serum beta-D-glucan levels were high, and the yellow purulent fluid obtained from the cyst was positive for Trichophyton rubrum. Granuloma formation in the cyst wall and large abscesses in the central cystic area were found, and septated hyphae were observed in both tissues. The cyst was surgically removed, and followed by itraconazole treatment...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28535932/charting-novel-allergens-from-date-palm-pollen-phoenix-sylvestris-using-homology-driven-proteomics
#16
Bodhisattwa Saha, Swati Gupta Bhattacharya
Pollen grains from Phoenix sylvestris (date palm), a commonly cultivated tree in India has been found to cause severe allergic diseases in an increasing percentage of hypersensitive individuals. To unearth its allergenic components, pollen protein were profiled by two-dimensional gel electrophoresis followed by immunoblotting with date palm pollen sensitive patient sera. Allergens were identified by MALDI-TOF/TOF employing a layered proteomic approach combining conventional database dependent search and manual de novo sequencing followed by homology-based search as Phoenix sylvestris is unsequenced...
May 20, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28531638/incorporation-of-beta-glucans-into-bread-postprandial-glucose-insulin-and-ghrelin-response-of-healthy-subjects
#17
Nikoleta S Stamataki, Amalia E Yanni, Maria G Stoupaki, Alexandros Tsigkas, Panagiotis Konstantopoulos, Irene Pateras, Nikolaos Tentolouris, Despina N Perrea, Vaios T Karathanos
No abstract text is available yet for this article.
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28521523/sepsis-in-internal-medicine-wards-current-knowledge-uncertainties-and-new-approaches-for-management-optimization
#18
Vincenzo Zaccone, Alberto Tosoni, Giovanna Passaro, Carla Vincenza Vallone, Michele Impagnatiello, Domenica Donatella Li Puma, Salvatore De Cosmo, Raffaele Landolfi, Antonio Mirijello
Sepsis represents a global health problem in terms of morbidity, mortality, social and economic costs. Although usually managed in Intensive Care Units, sepsis showed an increased prevalence among Internal Medicine wards in the last decade. This is substantially due to the ageing of population and to multi-morbidity. These characteristics represent both a risk factor for sepsis and a relative contra-indication for the admission to Intensive Care Units. Although there is a lack of literature on the management of sepsis in Internal Medicine, the outcome of these patients seems to be gradually improving...
May 27, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28507467/preparation-and-characterization-of-beta-glucan-particles-containing-a-payload-of-nanoembedded-rifabutin-for-enhanced-targeted-delivery-to-macrophages
#19
Tarun K Upadhyay, Nida Fatima, Deepak Sharma, V Saravanakumar, Rolee Sharma
β-glucan particles (GP) are polymeric carbohydrates, mainly found as components of cell wall fungi, yeast, bacteria and also in cereals such as barley and oat, and have been recently shown to have application in macrophage-targeted drug delivery. The aim of this study was to prepare and characterize GP containing a large payload of Rifabutin (RB), an anti-tuberculosis drug effective against MDR-TB at lower MIC than Rifampicin. GP were prepared from yeast cells by acidic and alkaline extraction were either spray dried or lyophilized, prior to RB loading and alginate sealing...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28504139/the-protective-role-of-phytate-in-the-oxidative-degradation-of-cereal-beta-glucans
#20
Yu-Jie Wang, Ruzhen Zhan, Tuula Sontag-Strohm, Ndegwa Henry Maina
This study investigated the role of phytate in the Fenton reaction induced oxidative degradation of cereal β-glucan. Viscosity analysis showed that the degradation rate was high in the beginning of oxidation, which fitted to the second order kinetic model. Oat β-glucan contained significant amount of residual phytate and after the residual phytate was removed, faster degradation was shown compared to the original oat β-glucan. Adding the same amount of phytic acid (PA) to the phytate removed β-glucan sample also retarded the degradation but not as efficiently as the residual phytate...
August 1, 2017: Carbohydrate Polymers
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