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Acidosis metabolic

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https://www.readbyqxmd.com/read/29237523/-clinical-analysis-of-15%C3%A2-851-children-at-risk-of-inherited-metabolic-diseases
#1
Shu-Xiang Lin, Jian-Bo Shu, Chao Wang, Rui Pan, Ying-Tao Meng, Chun-Hua Zhang, Bi-Li Zhang, Dan Wang, Yu-Qin Zhang
OBJECTIVE: To explore the value of urine gas chromatography-mass spectrometry (GC-MS) in the screening of children at risk of inherited metabolic diseases (IMD), and to identify the disease spectrum of IMD and the clinical characteristics of children with IMD. METHODS: The clinical data of 15 851 children at risk of IMD who underwent urine GC-MS in the Tianjin Children's Hospital between February 2012 and December 2016 were retrospectively analyzed. RESULTS: In the 15 851 children, 5 793 (36...
December 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29221627/alkaline-diet-and-metabolic-acidosis-practical-approaches-to-the-nutritional-management-of-chronic-kidney-disease
#2
Larissa Rodrigues Neto Angéloco, Gabriela Cristina Arces de Souza, Elen Almeida Romão, Paula Garcia Chiarello
The kidneys play an extremely important role in maintaining the body acid-base balance by excreting nonvolatile acids and regenerating and reabsorbing bicarbonate in the kidney tubules. As the individual loses their kidney function, renal excretion of nonvolatile acid produced by metabolism of the diet is impaired, resulting in low-grade metabolic acidosis. With this in mind, it is relevant to better understand the dietary aspects related to the acid-base balance in chronic kidney disease metabolic acidosis and try to provide possible strategies for the nutritional management of these cases...
December 5, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29220070/recurrent-hypokalemia-leading-to-flaccid-quadriparesis-a-renal-or-connective-tissue-disorder
#3
Nitin Bansal, Panda Ashwin Kumar, Mukul P Agarwal, Amitesh Aggarwal
Hypokalemic periodic paralysis (hypoKPP) is a clinical entity characterized by recurrent skeletal muscle paralysis due to a decrease in serum potassium levels; hypoKPP can have either a primary (familial) or a secondary cause. One of the secondary causes of hypoKPP is distal renal tubular acidosis (dRTA). Distal renal tubular acidosis (dRTA) is diagnosed when the urinary pH is greater than 5.3 and in the presence of hyperchloremic metabolic acidosis and hypokalemia, with one of the causes being primary Sjögren's syndrome (pSS)...
December 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29218437/d-lactic-acidosis-in-humans-systematic-literature-review
#4
Davide G A M Bianchetti, Giacomo S Amelio, Sebastiano A G Lava, Mario G Bianchetti, Giacomo D Simonetti, Carlo Agostoni, Emilio F Fossali, Gregorio P Milani
BACKGROUND: D-lactic acidosis is an uncommon and challenging form of metabolic acidosis that may develop in short bowel syndrome. It has been documented exclusively in case reports and small case series. METHODS: We performed a review of the literature in the National Library of Medicine and Excerpta Medica databases. RESULTS: We identified 84 original reports published between 1977 and 2017. D-lactic acidosis was observed in 98 individuals ranging in age from 7 months to 86 years with short bowel syndrome...
December 7, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29212873/lentiform-fork-sign-due-to-severe-metabolic-acidosis
#5
Arushi Gahlot Saini, Sreedeep Kodakkattil Sreevilasan, Paramjeet Singh, Pratibha Singhi
No abstract text is available yet for this article.
December 5, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29212593/-methylene-blue-against-refractory-hypotension
#6
Daniel Morgan, Maria Gelleberg Rasmussen, Anne Barklin
In this case report we describe a 62-year-old man, intoxicated with losartan, an angiotensin-II receptor antagonist. The patient presented with a systolic blood pressure of 60 mmHg, metabolic acidosis, and hyperglycaemia. His condition worsened within the first hour of arrival despite infusion of four litres of saline, epinephrine, norepinephrine, and vasopressin as well as insulin and antibiotics. Intravenous methylene blue 75 mg was infused over five minutes. Within 30 minutes his systolic pressure increased to 100 mmHg, and the infusion of epinephrine could be reduced four hours later...
December 4, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29211866/association-of-urinary-citrate-with-acid-base-status-bone-resorption-and-calcium-excretion-in-older-men-and-women
#7
M Kyla Shea, Bess Dawson-Hughes
Context: Elevated urine net acid excretion (NAE), indicative of subclinical metabolic acidosis, has been associated with higher bone turnover. While NAE is the gold-standard clinical measure of acid-base status, it is impractical to measure in most clinical/research settings. Urine citrate, which is commonly measured, changes in response to acid-base status, but its association with bone turnover is uncertain. Objective: To evaluate the association between change in urine citrate and change in bone turnover and calcium excretion...
December 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29203193/fructose-1-6-bisphosphatase-deficiency-as-a%C3%A2-cause-of-recurrent-hypoglycemia-and-metabolic-acidosis-clinical-and-molecular-findings-in-malaysian-patients
#8
Lip Hen Moey, Nor Azimah Abdul Azize, Yusnita Yakob, Huey Yin Leong, Wee Teik Keng, Bee Chin Chen, Lock Hock Ngu
BACKGROUND: Fructose-1,6-bisphosphatase (FBPase) deficiency is a rare autosomal recessive inborn error of gluconeogenesis. We reported the clinical findings and molecular genetic data in seven Malaysian patients with FBPase deficiency. METHODS: All patients diagnosed with FBPase deficiency from 2010 to 2015 were included in this study. Their clinical and laboratory data were collected retrospectively. RESULTS: All the patients presented with recurrent episodes of hypoglycemia, metabolic acidosis, hyperlactacidemia and hepatomegaly...
November 13, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29202719/an-in-vitro-splicing-assay-reveals-the-pathogenicity-of-a-novel-intronic-variant-in-atp6v0a4-for-autosomal-recessive-distal-renal-tubular-acidosis
#9
Tomohiko Yamamura, Kandai Nozu, Yuya Miyoshi, Keita Nakanishi, Junya Fujimura, Tomoko Horinouchi, Shogo Minamikawa, Nobuo Mori, Rika Fujimaru, Koichi Nakanishi, Takeshi Ninchoji, Hiroshi Kaito, Taniguchi-Ikeda Mariko, Ichiro Morioka, Masafumi Matsuo, Kazumoto Iijima
BACKGROUND: Autosomal recessive distal renal tubular acidosis (dRTA) is a rare hereditary disease caused by pathogenic variants in the ATP6V0A4 gene or ATP6V1B1 gene, and characterized by hyperchloremic metabolic acidosis with normal anion gap, hypokalemia, hypercalciuria, hypocitraturia and nephrocalcinosis. Although several intronic nucleotide variants in these genes have been detected, all of them fell in the apparent splice consensus sequence. In general, transcriptional analysis is necessary to determine the effect on function of the novel intronic variants located out of splicing consensus sequences...
December 4, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29201896/effect-of-glycine-pyruvate-and-resveratrol-on-the-regeneration-process-of-postischemic-intestinal-mucosa
#10
Lisa Brencher, Frank Petrat, Katrin Stych, Tim Hamburger, Michael Kirsch
Background: Intestinal ischemia is often caused by a malperfusion of the upper mesenteric artery. Since the intestinal mucosa is one of the most rapidly proliferating organs in human body, this tissue can partly regenerate itself after the onset of ischemia and reperfusion (I/R). Therefore, we investigated whether glycine, sodium pyruvate, and resveratrol can either support or potentially harm regeneration when applied therapeutically after reperfusion injury. Methods: I/R of the small intestine was initiated by occluding and reopening the upper mesenteric artery in rats...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29201470/a-novel-mutation-of-the-cyp11b2-in-a-saudi-infant-with-primary-hypoaldosteronism
#11
Lama Alfaraidi, Abrar Alfaifi, Rawan Alquaiz, Faten Almijmaj, Horia Mawlawi
Isolated hypoaldosteronism is a rare autosomal recessive disease presenting with severe salt wasting and failure to thrive in infancy. A 6-month-old Saudi girl born to consanguineous parents was referred from primary health care for failure to thrive and developmental delay. Laboratory tests revealed hyponatremia, hyperkalemia, and metabolic acidosis with high renin and low aldosterone. Blood samples were collected for endocrine and genetic studies. Sequence analysis of the CYP11B2 revealed a T to A transition at position 1398 + 2 in exon 8 of the gene in a homozygous state (c...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29199769/peritoneal-dialysis-for-acute-kidney-injury
#12
REVIEW
Linfeng Liu, Ling Zhang, Guan J Liu, Ping Fu
BACKGROUND: Peritoneal dialysis (PD) has been suggested as an effective and safe dialysis modality in patients with acute kidney injury (AKI). However, whether PD is superior to extracorporeal therapy (e.g. haemodialysis) in terms of improving survival, recovery of kidney function, metabolic and clinical outcomes is still inconclusive. OBJECTIVES: The aim of this review was to evaluate the benefits and harms of PD for patients with AKI compared with extracorporeal therapy or different PD modalities...
December 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29198517/choice-of-resuscitative-fluids-and-mortality-in-emergency-department-patients-with-sepsis
#13
Monica Sethi, Clark G Owyang, Chad Meyers, Ram Parekh, Kaushal H Shah, Alex F Manini
OBJECTIVE: Balanced resuscitative fluids (BF) have been associated with decreased incidence of hyperchloremic metabolic acidosis in sepsis. We hypothesized that higher proportions of BF during resuscitation would thus be associated with improved mortality in Emergency Department (ED) patients with sepsis. METHODS: This was a retrospective chart review of adult ED patients who presented with sepsis to a large, urban teaching hospital over one year. The choice of resuscitation fluid in the first 2days of hospitalization was defined as either normal saline (NS) or balanced fluids (BF; Lactated Ringer's or Isolyte)...
October 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29197835/kombucha-is-a-cup-of-tea-good-for-you
#14
Ailsa Holbourn, Judith Hurdman
A 54-year-old asthmatic woman presented to hospital with a 10-day history of breathlessness. On examination, she was tachypnoeic with mild wheeze. She had preserved peak flows and was saturating at 100% on room air. Investigations revealed severe metabolic lactic acidosis. On further questioning, it transpired that she drank kombucha tea, which has been linked to lactic acidosis. She made a full recovery with supportive management and cessation of the tea.
December 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29196311/unusual-cause-of-encephalopathy-after-brain-surgery
#15
Zayan Mahmooth, James G Malcolm, Jeremy S Wetzel, Faiz U Ahmad
For patients who have had a recent neurosurgical procedure, a visit to the emergency department for encephalopathy may automatically prompt a neurosurgical consult. We present a case of a patient with a history of Chiari malformation decompressed 6 months prior who presented with a 2-week history of slowly progressive altered mental status, headache and imbalance-symptoms consistent with her initial Chiari symptoms, so neurosurgery was consulted. Imaging showed no acute abnormality, but laboratory results revealed metabolic acidosis with high salicylate levels...
December 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29189867/-metformin-associated-lactic-acidosis-report-of-one-case
#16
Felipe Quintana, María José Pezzani, Rodrigo Orozco, Jorge Dreyse, Leonardo Soto, Tomás Regueira
Metformin-associated lactic acidosis is a severe and infrequent adverse event. Early diagnosis is essential to start an early treatment, which often has favorable results. We report a 56 years old non-insulin-requiring type 2 diabetic female who developed a severe metabolic acidosis associated with metformin in relation to an acute renal failure secondary to infectious diarrhea. Early treatment with bicarbonate and continuous hemofiltration allowed a quick improvement of the patient. Metformin-associated lactic acidosis has an elevated mortality (50-80%) and has a specific and effective treatment...
August 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29183766/ketogenic-diet-using-a-japanese-ketogenic-milk-for-patients-with-epilepsy-a-multi-institutional-study
#17
Tomohiro Kumada, Katsumi Imai, Yukitoshi Takahashi, Shin Nabatame, Hirokazu Oguni
BACKGROUND: In Japan, Meiji 817-B (M817-B), a powdered ketogenic milk, has been available since the ketogenic diet was introduced to infants and tube-fed children with medication-resistant epilepsy in the 1980s. METHODS: We retrospectively evaluated the efficacy, tolerability, and side effects of the ketogenic diet using M817-B as the main source of daily food intake for patients with epilepsy by sending questionnaires to the members of a subcommittee of the Japan Epilepsy Society that focuses on the proper use of M817-B...
November 25, 2017: Brain & Development
https://www.readbyqxmd.com/read/29182206/-mckrittick-wheelock-syndrome-report-of-one-case
#18
Alejandro Kral, Jorge Vega
McKittrick-Wheelock syndrome is caused by chronic water and electrolyte hypersecretion from an intestinal tumor, usually a villous adenoma, located in the rectum or sigmoid. Patients often have dehydration, hypovolemic shock and kidney failure associated with hypokalemia, hyponatremia, hypochloremia and metabolic acidosis. We report a 62-year-old male, suffering chronic diarrhea for eight years who was admitted after a syncope. He had severe hypokalemia, hyponatremia, metabolic acidosis, hypovolemia and acute renal failure...
July 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29181745/salicylate-intoxication-in-an-infant-a-case-report
#19
Rita Espírito Santo, Sara Vaz, Filipa Jalles, Leonor Boto, Francisco Abecasis
In children, the most common cause of an elevated anion gap (AG) with ketonemia, ketonuria, hyperglycemia, and glycosuria is diabetic ketoacidosis. However, when the clinical history is not clear, other causes must be considered. A 9-month-old girl was transferred to our pediatric intensive care unit (PICU) because of severe metabolic acidosis. On admission, she presented with Kussmaul breathing, tachycardia, irritability, and fever. Blood gasses revealed metabolic acidosis with superimposed respiratory alkalosis and elevated AG...
November 27, 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29179031/innate-immune-responses-to-metabolic-stress-can-be-detected-in-rumen-fluids
#20
Erminio Trevisi, Federica Riva, Joel Fernando Soares Filipe, Matteo Massara, Andrea Minuti, Paolo Bani, Massimo Amadori
Many production diseases of dairy cows are related to digestive troubles. The rumen subacute acidosis is the most relevant one, albeit not easily recognized. Recent studies suggest that forestomachs can perform regulatory actions at both regional and systemic levels, since forestomach walls express immune receptors and cytokines, and the rumen liquor is infiltrated by leukocytes. Therefore, the rumen fluid could be conveniently collected for investigating metabolic production diseases. Thus, we investigated the origin of the leukocytes of the rumen fluid and demonstrated that they partly derive from saliva...
November 21, 2017: Research in Veterinary Science
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