keyword
https://read.qxmd.com/read/38221811/vaginal-reconstruction-by-collagen-scaffolds-loaded-with-vaginal-epithelial-and-smooth-muscle-cells-in-pigs
#21
JOURNAL ARTICLE
Guangfeng Zhao, Yishan Dong, Ziying Ye, Simin Yao, Limin Wang, Yannan Zhao, Bing Chen, Dan Liu, Jianwu Dai, Yali Hu
In women, a healthy and functional vagina is important for the maintenance of a good quality of life. Various factors, including congenital anomalies, cancer, trauma, infections, inflammation, or iatrogenic injuries, can lead to damage or loss of the vaginal structure, necessitating repair or replacement. Often, such reconstruction procedures involve the use of nonvaginal tissue substitutes, like segments of the large intestine or skin, which are less than ideal both anatomically and functionally. Therefore, there is an urgent need to develop new methods of vaginal reconstruction...
January 15, 2024: Biomaterials Science
https://read.qxmd.com/read/38219450/three-dimensional-printing-and-decellularized-extracellular-matrix-based-methods-for-advances-in-artificial-blood-vessel-fabrication-a-review
#22
REVIEW
Bing Li, Yan Shu, Hailin Ma, Kun Cao, Yuen Yee Cheng, Zhilin Jia, Xiao Ma, Hongfei Wang, Kedong Song
Blood vessels are the tubes through which blood flows and are divided into three types: millimeter-scale arteries, veins, and capillaries as well as micrometer-scale capillaries. Arteries and veins are the conduits that carry blood, while capillaries are where blood exchanges substances with tissues. Blood vessels are mainly composed of collagen fibers, elastic fibers, glycosaminoglycans and other macromolecular substances. There are about 19 feet of blood vessels per square inch of skin in the human body, which shows how important blood vessels are to the human body...
January 5, 2024: Tissue & Cell
https://read.qxmd.com/read/38201731/poly-%C3%AE%C2%B5-caprolactone-3d-printed-porous-scaffold-in-a-femoral-condyle-defect-model-induces-early-osteo-regeneration
#23
JOURNAL ARTICLE
Arianna De Mori, Aikaterina Karali, Evangelos Daskalakis, Richard Hing, Paulo Jorge Da Silva Bartolo, Glen Cooper, Gordon Blunn
Large bone reconstruction following trauma poses significant challenges for reconstructive surgeons, leading to a healthcare burden for health systems, long-term pain for patients, and complex disorders such as infections that are difficult to resolve. The use of bone substitutes is suboptimal for substantial bone loss, as they induce localized atrophy and are generally weak, and unable to support load. A combination of strong polycaprolactone (PCL)-based scaffolds, with an average channel size of 330 µm, enriched with 20% w / w of hydroxyapatite (HA), β-tricalcium phosphate (TCP), or Bioglass 45S5 (Bioglass), has been developed and tested for bone regeneration in a critical-size ovine femoral condyle defect model...
December 24, 2023: Polymers
https://read.qxmd.com/read/38192168/intersection-of-immunity-metabolism-and-muscle-regeneration-in-an-autoimmune-prone-mrl-mouse-model
#24
JOURNAL ARTICLE
Tran B Ngo, Aditya Josyula, Sabrina DeStefano, Daphna Fertil, Mondreakest Faust, Ravi Lokwani, Kaitlyn Sadtler
Due to the limited capacity of mammals to regenerate complex tissues, researchers have worked to understand the mechanisms of tissue regeneration in organisms that maintain that capacity. One example is the MRL/MpJ mouse strain with unique regenerative capacity in ear pinnae that is absent from other strains, such as the common C57BL/6 strain. The MRL/MpJ mouse has also been associated with an autoimmune phenotype even in the absence of the mutant Fas gene described in its parent strain MRL/lpr. Due to these findings, the differences between the responses of MRL/MpJ versus C57BL/6 strain are evaluated in volumetric muscle injury and subsequent material implantation...
January 8, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38187908/nanoparticle-facilitated-therapy-advancing-tools-in-peripheral-nerve-regeneration
#25
REVIEW
Shaoyan Shi, Xuehai Ou, Deliang Cheng
Peripheral nerve injuries, arising from a diverse range of etiologies such as trauma and underlying medical conditions, pose substantial challenges in both clinical management and subsequent restoration of functional capacity. Addressing these challenges, nanoparticles have emerged as a promising therapeutic modality poised to augment the process of peripheral nerve regeneration. However, a comprehensive elucidation of the complicated mechanistic foundations responsible for the favorable effects of nanoparticle-based therapy on nerve regeneration remains imperative...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38175154/implantable-bioelectrodes-challenges-strategies-and-future-directions
#26
REVIEW
Mengyuan Hu, Chunyong Liang, Donghui Wang
Implantable bioelectrodes for regulating and monitoring biological behaviors have become indispensable medical devices in modern healthcare, alleviating pathological symptoms such as epilepsy and arrhythmia, and assisting in reversing conditions such as deafness and blindness. In recent years, developments in the fields of materials science and biomedical engineering have contributed to advances in research on implantable bioelectrodes. However, the foreign body reaction (FBR) is still a major constraint for the long-term application of electrodes...
January 4, 2024: Biomaterials Science
https://read.qxmd.com/read/38166512/biomaterials-for-bone-defect-repair-types-mechanisms-and-effects
#27
REVIEW
Jiaming Wang, Mingchong Liu, Chensong Yang, Yutao Pan, Shengchao Ji, Ning Han, Guixin Sun
Bone defects or bone discontinuities caused by trauma, infection, tumours and other diseases have led to an increasing demand for bone grafts and biomaterials. Autologous bone grafts, bone grafts with vascular tips, anastomosed vascular bone grafts and autologous bone marrow components are all commonly used in clinical practice, while oversized bone defects require the use of bone tissue engineering-related biomaterials to repair bone defects and promote bone regeneration. Currently, inorganic components such as polysaccharides and bioceramics, as well as a variety of bioactive proteins, metal ions and stem cells can be loaded into hydrogels or 3D printed scaffold materials to achieve better therapeutic results...
January 2, 2024: International Journal of Artificial Organs
https://read.qxmd.com/read/38161006/pharmaceutical-applications-of-chitosan-in-skin-regeneration-a-review
#28
REVIEW
Jie Wang, Xunxin Duan, Donghuo Zhong, Mengqi Zhang, Jianying Li, Zhijian Hu, Feng Han
Skin regeneration is the process that restores damaged tissues. When the body experiences trauma or surgical incisions, the skin and tissues on the wound surface become damaged. The body repairs this damage through complex physiological processes to restore the original structural and functional states of the affected tissues. Chitosan, a degradable natural bioactive polysaccharide, has attracted widespread attention partly owing to its excellent biocompatibility and antimicrobial properties; additionally, a modified form of this compound has been shown to promote skin regeneration...
December 29, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38118130/advances-in-3d-printing-of-highly-bioadaptive-bone-tissue-engineering-scaffolds
#29
REVIEW
Ya Ren, Changru Zhang, Yihao Liu, Weiqing Kong, Xue Yang, Haoyi Niu, Lei Qiang, Han Yang, Fei Yang, Chengwei Wang, Jinwu Wang
The number of patients with bone defects caused by trauma, bone tumors, and osteoporosis has increased considerably. The repair of irregular, recurring, and large bone defects poses a great challenge to clinicians. Bone tissue engineering is emerging as an appropriate strategy to replace autologous bone grafting in the repair of critically sized bone defects. However, the suitability of bone tissue engineering scaffolds in terms of structure, mechanics, degradation, and the microenvironment is inadequate. Three-dimensional (3D) printing is an advanced additive-manufacturing technology widely used for bone repair...
December 20, 2023: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38108530/performance-of-collagen-based-matrices-from-nile-tilapia-skin-a-pilot-proteomic-study-in-a-murine-model-of-wound-healing
#30
JOURNAL ARTICLE
Cláudia B A Medeiros, Iasmim Lopes de Lima, Thiago Barbosa Cahú, Bruna R Muniz, Maria Helena M L Ribeiro, Érico Higino de Carvalho, Marcos Nogueira Eberlin, Marcelo J B Miranda, Ranilson de Souza Bezerra, Roberto Afonso da Silva, José Luiz de Lima Filho
Full-thickness cutaneous trauma, due to the lack of dermis, leads to difficulty in epithelialization by keratinocytes, developing a fibrotic scar, with less elasticity than the original skin, which may have disorders in predisposed individuals, resulting in hypertrophic scar and keloids. Biomedical materials have excellent characteristics, such as good biocompatibility and low immunogenicity, which can temporarily replace traditional materials used as primary dressings. In this work, we developed two dermal matrices based on Nile tilapia collagen, with (M_GAG) and without (M) glycosaminoglycans, using a sugarcane polymer membrane as a matrix support...
January 2024: Journal of Mass Spectrometry: JMS
https://read.qxmd.com/read/38102098/preparation-and-application-of-hemostatic-hydrogels
#31
REVIEW
Minyu Zhou, Xiang Lin, Li Wang, Chaoyu Yang, Yunru Yu, Qingfei Zhang
Hemorrhage remains a critical challenge in various medical settings, necessitating the development of advanced hemostatic materials. Hemostatic hydrogels have emerged as promising solutions to address uncontrolled bleeding due to their unique properties, including biocompatibility, tunable physical characteristics, and exceptional hemostatic capabilities. In this review, a comprehensive overview of the preparation and biomedical applications of hemostatic hydrogels is provided. Particularly, hemostatic hydrogels with various materials and forms are introduced...
December 15, 2023: Small
https://read.qxmd.com/read/38101067/spheroids-as-a-3d-in-vitro-model-to-study-bone-and-bone-mineralization
#32
REVIEW
Diamante Boscaro, Pawel Sikorski
Traumas, fractures, and diseases can severely influence bone tissue. Insight into bone mineralization is essential for the development of therapies and new strategies to enhance bone regeneration. 3D cell culture systems, in particular cellular spheroids, have gained a lot of interest as they can recapitulate crucial aspects of the in vivo tissue microenvironment, such as the extensive cell-cell and cell-extracellular matrix (ECM) interactions found in tissue. The potential of combining spheroids and various classes of biomaterials opens also new opportunities for research within bone tissue engineering...
December 10, 2023: Biomater Adv
https://read.qxmd.com/read/38024227/biomaterial-scaffolds-in-maxillofacial-bone-tissue-engineering-a-review-of-recent-advances
#33
REVIEW
Xiangya Huang, Yaxin Lou, Yihong Duan, He Liu, Jun Tian, Ya Shen, Xi Wei
Maxillofacial bone defects caused by congenital malformations, trauma, tumors, and inflammation can severely affect functions and aesthetics of maxillofacial region. Despite certain successful clinical applications of biomaterial scaffolds, ideal bone regeneration remains a challenge in maxillofacial region due to its irregular shape, complex structure, and unique biological functions. Scaffolds that address multiple needs of maxillofacial bone regeneration are under development to optimize bone regeneration capacity, costs, operational convenience...
March 2024: Bioactive Materials
https://read.qxmd.com/read/38020233/magnesium-based-alloys-with-adapted-interfaces-for-bone-implants-and-tissue-engineering
#34
REVIEW
Iulian Antoniac, Veronica Manescu Paltanea, Aurora Antoniac, Gheorghe Paltanea
Magnesium and its alloys are one of the most used materials for bone implants and tissue engineering. They are characterized by numerous advantages such as biodegradability, high biocompatibility and mechanical properties with values close to the human bone. Unfortunately, the implant surface must be adequately tuned, or Mg-based alloys must be alloyed with other chemical elements due to their increased corrosion effect in physiological media. This article reviews the clinical challenges related to bone repair and regeneration, classifying bone defects and presenting some of the most used and modern therapies for bone injuries, such as Ilizarov or Masquelet techniques or stem cell treatments...
2023: Regenerative Biomaterials
https://read.qxmd.com/read/37997512/multifunctional-cationic-hyperbranched-polyaminoglycosides-that-target-multiple-mediators-for-severe-abdominal-trauma-management
#35
JOURNAL ARTICLE
Yongqiang Xiao, He Fang, Yuefei Zhu, Jie Zhou, Zhanzhan Dai, Hongxia Wang, Zhaofan Xia, Zhaoxu Tu, Kam W Leong
Trauma and its associated complications, including dysregulated inflammatory responses, severe infection, and disseminated intravascular coagulation (DIC), continue to pose lethal threats worldwide. Following injury, cell-free nucleic acids (cfNAs), categorized as damage-associated molecular patterns (DAMPs), are released from dying or dead cells, triggering local and systemic inflammatory responses and coagulation abnormalities that worsen disease progression. Harnessing cfNA scavenging strategies with biomaterials has emerged as a promising approach for treating posttrauma systemic inflammation...
November 23, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/37991846/biohybrid-neural-interfaces-improving-the-biological-integration-of-neural-implants
#36
REVIEW
Marjolaine Boulingre, Roberto Portillo-Lara, Rylie A Green
Implantable neural interfaces (NIs) have emerged in the clinic as outstanding tools for the management of a variety of neurological conditions caused by trauma or disease. However, the foreign body reaction triggered upon implantation remains one of the major challenges hindering the safety and longevity of NIs. The integration of tools and principles from biomaterial design and tissue engineering has been investigated as a promising strategy to develop NIs with enhanced functionality and performance. In this Feature Article, we highlight the main bioengineering approaches for the development of biohybrid NIs with an emphasis on relevant device design criteria...
November 22, 2023: Chemical Communications: Chem Comm
https://read.qxmd.com/read/37977006/regenerative-capacity-of-neural-tissue-scales-with-changes-in-tissue-mechanics-post-injury
#37
JOURNAL ARTICLE
Alejandro Carnicer-Lombarte, Damiano G Barone, Filip Wronowski, George G Malliaras, James W Fawcett, Kristian Franze
Spinal cord injuries have devastating consequences for humans, as mammalian neurons of the central nervous system (CNS) cannot regenerate. In the peripheral nervous system (PNS), however, neurons may regenerate to restore lost function following injury. While mammalian CNS tissue softens after injury, how PNS tissue mechanics changes in response to mechanical trauma is currently poorly understood. Here we characterised mechanical rat nerve tissue properties before and after in vivo crush and transection injuries using atomic force microscopy-based indentation measurements...
November 9, 2023: Biomaterials
https://read.qxmd.com/read/37961412/in-vivo-biomedical-imaging-of-immune-tolerant-radiopaque-nanoparticle-embedded-polymeric-device-degradation
#38
Kendell M Pawelec, Jeremy M L Hix, Arianna Troia, Matti Kiupel, Erik Shapiro
Biomedical implants remain an important clinical tool for restoring patient mobility and quality of life after trauma. While polymers are often used for devices, their degradation profile remains difficult to determine post-implantation. CT monitoring could be a powerful tool for in situ monitoring of devices, but polymers require the introduction of radiopaque contrast agents, like nanoparticles, to be distinguishable from native tissue. As device function is mediated by the immune system, use of radiopaque nanoparticles for serial monitoring therefore requires a minimal impact on inflammatory response...
October 30, 2023: bioRxiv
https://read.qxmd.com/read/37959593/collagen-coated-hyperelastic-bone-promotes-osteoblast-adhesion-and-proliferation
#39
JOURNAL ARTICLE
Andrei Gresita, Iman Raja, Eugen Petcu, Michael Hadjiargyrou
Successfully reconstructing bone and restoring its dynamic function represents a significant challenge for medicine. Critical size defects (CSDs), resulting from trauma, tumor removal, or degenerative conditions, do not naturally heal and often require complex bone grafting. However, these grafts carry risks, such as tissue rejection, infections, and surgical site damage, necessitating the development of alternative treatments. Three-dimensional and four-dimensional printed synthetic biomaterials represent a viable alternative, as they carry low production costs and are highly reproducible...
November 1, 2023: Materials
https://read.qxmd.com/read/37948229/ultrasound-activated-piezoelectric-polyvinylidene-fluoride-trifluoroethylene-scaffolds-for-tissue-engineering-applications
#40
JOURNAL ARTICLE
Andrew E Bryan, Maksym Krutko, Jennifer Westphal, Maulee Sheth, Leyla Esfandiari, Greg M Harris
Severe peripheral nervous system (PNS) injuries have limited options for therapeutic solutions to regain functional recovery. This can be attributed in part to the lack of regeneration pathways promoted by recapitulating chemical, physical, and electrical cues to direct nerve guidance. To address this, we examined ultrasonic stimulation of a piezoelectric polyvinylidene fluoride-triflouroethylene (PVDF-TrFE) scaffold as a potentially clinically relevant therapy for PNS regeneration. Owing to the piezoelectric modality of PVDF-TrFE, we hypothesize that ultrasound stimulation will activate the scaffold to electrically stimulate cells in response to the mechanical deformation mediated by sound waves...
November 8, 2023: Military Medicine
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