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https://www.readbyqxmd.com/read/28285076/functional-poly-%C3%AE%C2%B5-caprolactone-chitosan-dressings-with-nitric-oxide-releasing-property-improve-wound-healing
#1
Xin Zhou, He Wang, Jimin Zhang, Xuemei Li, Yifan Wu, Yongzhen Wei, Ji Shenglu, Deling Kong, Qiang Zhao
Wound healing dressings are increasingly needed clinically due to the large number of skin damage annually. Nitric oxide (NO) plays a key role in promoting wound healing, thus biomaterials with NO-releasing property receive increasing attention as ideal wound dressing. In present study, we prepared a novel functional wound dressing by combining electrospun poly(ε-caprolactone) (PCL) nonwoven mat with chitosan-based NO-releasing biomaterials (CS-NO). As-prepared PCL/CS-NO dressing released NO sustainably under the physiological conditions, which was controlled by the catalysis of β-galactosidase...
March 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28210405/titanium-clamps-for-a-simple-low-profile-autologous-osteosynthesis-in-the-reconstruction-of-posttraumatic-craniofacial-convexital-skeletal-disruption
#2
Amos Olufemi Adeleye, Toluyemi Adefolarin Malomo
Attempts at reconstruction of posttraumatic craniofacial defects (PTCDs) can be a challenge in low-resource practice areas of the world where the needed biomaterials are logistically beyond reach. A simple low-profile technique of autologous osteosynthesis for PTCD using the titanium clamps is presented in this report. In addition, a 6-year prospective database on a consecutive cohort of patients who underwent this procedure was analyzed for clinical, functional, and aesthetic outcomes, both in-hospital and at midterm follow-up...
March 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28191761/angiogenic-potential-of-human-bone-marrow-derived-mesenchymal-stem-cells-in-chondrocyte-brick-enriched-constructs-promoted-stable-regeneration-of-craniofacial-cartilage
#3
Zhiye Li, Ruikai Ba, Zhifa Wang, Jianhua Wei, Yimin Zhao, Wei Wu
Craniofacial deformities caused by congenital defects or trauma remain challenges for clinicians, whereas current surgical interventions present limited therapeutic outcomes. Injection of bone marrow-derived mesenchymal stem cells (BMSCs) into the defect is highly desirable because such a procedure is microinvasive and grafts are more flexible to fill the lesions. However, preventing hypertrophic transition and morphological contraction remain significant challenges. We have developed an "all host derived" cell transplantation system composed of chondrocyte brick (CB)-enriched platelet-rich plasma (P) gel and BMSCs (B)...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28169594/keratin-hydrogel-enhances-in-vivo-skeletal-muscle-function-in-a-rat-model-of-volumetric-muscle-loss
#4
Juliana A Passipieri, Hannah B Baker, Mevan Siriwardane, Mary Ellenburg, Manasi Vadhavkar, Justin M Saul, Seth Tomblyn, Luke Burnett, George Joseph Christ
Volumetric Muscle Loss (VML) injuries exceed the considerable intrinsic regenerative capacity of skeletal muscle resulting in permanent functional and cosmetic deficits. VML and VML-like injuries occur in military and civilian populations, due to trauma and surgery as well as a host of congenital and acquired diseases/syndromes. Current therapeutic options are limited, and new approaches are needed for more complete functional regeneration of muscle. A potential solution is human hair derived keratin (KN) biomaterials that may have significant potential for regenerative therapy...
February 7, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28128224/pyrintegrin-induces-soft-tissue-formation-by-transplanted-or-endogenous-cells
#5
Bhranti S Shah, Mo Chen, Takahiro Suzuki, Mildred Embree, Kimi Kong, Chang H Lee, Ling He, Lusai Xiang, Jeffrey A Ahn, Sheng Ding, Jeremy J Mao
Focal adipose deficiency, such as lipoatrophy, lumpectomy or facial trauma, is a formidable challenge in reconstructive medicine, and yet scarcely investigated in experimental studies. Here, we report that Pyrintegrin (Ptn), a 2,4-disubstituted pyrimidine known to promote embryonic stem cells survival, is robustly adipogenic and induces postnatal adipose tissue formation in vivo of transplanted adipose stem/progenitor cells (ASCs) and recruited endogenous cells. In vitro, Ptn stimulated human adipose tissue derived ASCs to differentiate into lipid-laden adipocytes by upregulating peroxisome proliferator-activated receptor (PPARγ) and CCAAT/enhancer-binding protein-α (C/EBPα), with differentiated cells increasingly secreting adiponectin, leptin, glycerol and total triglycerides...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27890227/emerging-biomaterials-in-trauma
#6
REVIEW
Kirollos E Zakhary, Jayini S Thakker
Emerging technologies and research into the science of biomaterials have developed exponentially and provide facial reconstructive surgeons with a plethora of options for a multitude of varying presentations. This article presents a comprehensive discussion in the ever-evolving field of material science and emerging biomaterials. A complete understanding of the current status of such materials is necessary for the appropriate incorporation and applicability to adequate clinical situations. The rapid progress seen in biomaterials is evidenced through the forward direction of bioengineered tissues, the incorporation of growth factors in varying scenarios, and the unique characteristics of 3-D printing of patient specific scaffolds...
February 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/27771489/tailoring-biomaterial-scaffolds-for-osteochondral-repair
#7
Sandra Camarero-Espinosa, Justin Cooper-White
Articular cartilage is a mechanically and structurally complex, lubricious tissue that permits load-bearing and frictionless movement of our joints upon articulation. Unfortunately, cartilage is unable to properly self-heal as a result of acute trauma or damage, resulting in many cases in significant pain, reduction in physical activity and quality of life for the patient. Due to the inability of resident cells to repair damaged osteochondral tissue, researchers have focused on utilizing endogenously or exogenously sourced cells (chondrocytes or tissue-derived mesenchymal stem cells), with or without scaffolds, to encourage the secretion of extracellular matrix (ECM) that replicates this highly anisotropic osteochondral tissue, in which the phenotype of the cells and the composition and orientation of the ECM varies along its depth...
October 19, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27722242/periosteum-tissue-engineering-a-review
#8
Nanying Li, Juqing Song, Guanglin Zhu, Xiaoyu Li, Lei Liu, Xuetao Shi, Yingjun Wang
As always, the clinical therapy of critical size bone defects caused by trauma, tumor removal surgery or congenital malformation is facing great challenges. Currently, various approaches including autograft, allograft and cell-biomaterial composite based tissue-engineering strategies have been implemented to reconstruct injured bone. However, due to damage during the transplantation processes or design negligence of the bionic scaffolds, these methods expose vulnerabilities without the assistance of periosteum, a bilayer membrane on the outer surface of the bone...
October 18, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27663975/prevention-of-adhesions-in-the-temporomandibular-joint-by-the-use-of-chitosan-membrane-in-goats
#9
H P Li, S F Sun, B T Fan, P Shen, J S Zheng, S Y Zhang
We evaluated the effects of chitosan membrane, a highly absorbable and viscous material, in the prevention of intra-articular adhesions after anchoring of the disc in the temporomandibular joints (TMJ) of six adult goats (12 joints). To simulate anterior displacement of the disc and TMJ trauma, we cut off the retrodiscal attachment and damaged the surface of the condylar bone, then randomly divided the goats into two groups: the control group (n=2) and the experimental group (n=4). In the experimental group we covered the condylar surfaces on both sides of the animals with chitosan membranes...
January 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27629763/angiogenic-potential-of-human-bone-marrow-derived-mesenchymal-stem-cells-in-chondrocyte-brick-enriched-constructs-promoted-stable-regeneration-of-craniofacial-cartilage
#10
Zhiye Li, Ruikai Ba, Zhifa Wang, Jianhua Wei, Yimin Zhao, Wei Wu
: Craniofacial deformities caused by congenital defects or trauma remain challenges for clinicians, whereas current surgical interventions present limited therapeutic outcomes. Injection of bone marrow-derived mesenchymal stem cells (BMSCs) into the defect is highly desirable because such a procedure is microinvasive and grafts are more flexible to fill the lesions. However, preventing hypertrophic transition and morphological contraction remain significant challenges. We have developed an "all host derived" cell transplantation system composed of chondrocyte brick (CB)-enriched platelet-rich plasma (P) gel and BMSCs (B)...
September 14, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27617375/regenerative-endodontic-treatment-versus-apical-plug-in-immature-teeth-three-year-follow-up
#11
COMPARATIVE STUDY
Saeed Asgary, Mahta Fazlyab, Ali Nosrat
This report compares and evaluates the treatment outcomes of regenerative endodontic treatment and apical plug as two accepted treatment protocols in a pair of necrotic immature maxillary central incisors of a 12-year old female. The patient was referred complaining of a dull pain and swelling in her upper lip area. She had a history of trauma to the anterior maxilla two years earlier. Both teeth were clinically diagnosed with pulp necrosis and periapical radiographs revealed that separate periapical radiolucent lesions surrounded the immature apices of both teeth...
2016: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27617188/strategies-and-first-advances-in-the-development-of-prevascularized-bone-implants
#12
REVIEW
Christoph Rücker, Holger Kirch, Oliver Pullig, Heike Walles
Despite the great regenerative potential of human bone, large bone defects are a serious condition. Commonly, large defects are caused by trauma, bone disease, malignant tumor removal, and infection or medication-related osteonecrosis. Large defects necessitate clinical treatment in the form of autologous bone transplantation or implantation of biomaterials as well as the application of other available methods that enhance bone defect repair. The development and application of prevascularized bone implants are closely related to the development animal models and require dedicated methods in order to reliably predict possible clinical outcomes and the efficacy of implants...
2016: Current Molecular Biology Reports
https://www.readbyqxmd.com/read/27612842/orbital-implants-state-of-the-art-review-with-emphasis-on-biomaterials-and-recent-advances
#13
REVIEW
Francesco Baino, Isabel Potestio
In the treatment of severe oculo-orbital traumas, intraocular malignancies or other life-threatening conditions it is sometimes necessary to surgically remove the patient's diseased eye. Following the removal of the eye, an orbital implant is inserted into the anophthalmic socket in order to provide satisfactory volume replacement and restore the aesthetic appearance of a normal eye. Over the last decades, the implant design and the criteria of materials selection evolved from simple non-porous polymeric sphere to devices with more complex shape and functionalities for ensuring better clinical outcomes in the long-term...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27599801/current-strategies-for-integrative-cartilage-repair
#14
Margaret K Boushell, Clark T Hung, Ernst B Hunziker, Eric J Strauss, Helen H Lu
Osteoarthritis (OA) is a degenerative joint condition characterized by painful cartilage lesions that impair joint mobility. Current treatments such as lavage, microfracture, and osteochondral implantation fail to integrate newly formed tissue with host tissues and establish a stable transition to subchondral bone. Similarly, tissue-engineered grafts that facilitate cartilage and bone regeneration are challenged by how to integrate the graft seamlessly with surrounding host cartilage and/or bone. This review centers on current approaches to promote cartilage graft integration...
September 6, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27598960/hallmarks-in-the-history-of-orthopaedic-implants-for-trauma-and-joint-replacement
#15
REVIEW
Konstantinos Markatos, Gregory Tsoucalas, Markos Sgantzos
This manuscript represents an attempt to review orthopaedic implants and reconstructive orthopaedic surgery for lower limbs lesions or trauma mainly in the 20th century. We emphasized on the type of implants, the biomaterials and their evolution, and we also engaged in a special reference for the pioneers of orthopaedic implant surgery and the innovative designers of those implants, in such a way to understand the ways and the stages through which they evolved to their present forms, as well as the scientific principles that affected their design and progress...
August 2016: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/27521494/novel-bioceramic-reinforced-hydrogel-for-alveolar-bone-regeneration
#16
Giorgio Iviglia, Clara Cassinelli, Elisa Torre, Francesco Baino, Marco Morra, Chiara Vitale-Brovarone
UNLABELLED: The osseointegration of dental implants and their consequent long-term success is guaranteed by the presence, in the extraction site, of healthy and sufficient alveolar bone. Bone deficiencies may be the result of extraction traumas, periodontal disease and infection. In these cases, placement of titanium implants is contraindicated until a vertical bone augmentation is obtained. This goal is achieved using bone graft materials, which should simulate extracellular matrix (ECM), in order to promote osteoblast proliferation and fill the void, maintaining the space without collapsing until the new bone is formed...
October 15, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27475528/combination-scaffolds-of-salmon-fibrin-hyaluronic-acid-and-laminin-for-human-neural-stem-cell-and-vascular-tissue-engineering
#17
Janahan Arulmoli, Heather J Wright, Duc T T Phan, Urmi Sheth, Richard A Que, Giovanni A Botten, Mark Keating, Elliot L Botvinick, Medha M Pathak, Thomas I Zarembinski, Daniel S Yanni, Olga V Razorenova, Christopher C W Hughes, Lisa A Flanagan
UNLABELLED: Human neural stem/progenitor cells (hNSPCs) are good candidates for treating central nervous system (CNS) trauma since they secrete beneficial trophic factors and differentiate into mature CNS cells; however, many cells die after transplantation. This cell death can be ameliorated by inclusion of a biomaterial scaffold, making identification of optimal scaffolds for hNSPCs a critical research focus. We investigated the properties of fibrin-based scaffolds and their effects on hNSPCs and found that fibrin generated from salmon fibrinogen and thrombin stimulates greater hNSPC proliferation than mammalian fibrin...
October 1, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27435965/injectable-gentamicin-loaded-thermo-responsive-hyaluronic-acid-derivative-prevents-infection-in-a-rabbit-model
#18
Gert-Jan A Ter Boo, Daniel Arens, Willem-Jan Metsemakers, Stephan Zeiter, R Geoff Richards, Dirk W Grijpma, David Eglin, T Fintan Moriarty
UNLABELLED: Despite the use of systemic antibiotic prophylaxis, the surgical fixation of open fractures with osteosynthesis implants is associated with high infection rates. Antibiotic-loaded biomaterials (ALBs) are increasingly used in implant surgeries across medical specialties to deliver high concentrations of antibiotics to the surgical site and reduce the risk of implant-associated infection. ALBs which are either less or not restricted in terms of spatial distribution and which may be applied throughout complex wounds could offer improved protection against infection in open fracture care...
October 1, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27424990/amniotic-fluid-stem-cells-an-ideal-resource-for-therapeutic-application-in-bone-tissue-engineering
#19
A Pantalone, I Antonucci, M Guelfi, P Pantalone, F G Usuelli, L Stuppia, V Salini
OBJECTIVE: Skeletal diseases, both degenerative and secondary to trauma, infections or tumors, represent an ideal target for regenerative medicine and in the last years, stem cells have been considered as good candidates for in vitro and in vivo bone regeneration. To date, several stem cell sources, such as adult mesenchymal stem cells, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), have shown significant osteogenic potential. MATERIALS AND METHODS: In this narrative review, we analyze the possible advantages of the use of AFSCs in the treatment of skeletal diseases, especially through the application of tissue engineering and biomaterials...
July 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27400843/controversies-in-the-management-of-the-trauma-patient
#20
REVIEW
Regina E Rodman, Robert M Kellman
Facial trauma is a significant cause of morbidity in the United States. Despite the large volume of trauma surgeries at most academic institutions, there is still controversy regarding management of many traumatic injuries. The literature lacks clear-cut best practices for most fractures. In orbital trauma, there is debate about the optimal timing of repair, preferred biomaterial to be used, and the utility of evaluation afterward with intraoperative computed tomographic scan. In repair of mandible fractures, there is debate regarding open versus closed reduction of subcondylar fractures, or alternatively, endoscopic repair...
August 2016: Facial Plastic Surgery Clinics of North America
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