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https://www.readbyqxmd.com/read/27890227/emerging-biomaterials-in-trauma
#1
REVIEW
Kirollos E Zakhary, Jayini S Thakker
Emerging technologies and research into the science of biomaterials have developed exponentially and provide facial reconstructive surgeons with a plethora of options for a multitude of varying presentations. This article presents a comprehensive discussion in the ever-evolving field of material science and emerging biomaterials. A complete understanding of the current status of such materials is necessary for the appropriate incorporation and applicability to adequate clinical situations. The rapid progress seen in biomaterials is evidenced through the forward direction of bioengineered tissues, the incorporation of growth factors in varying scenarios, and the unique characteristics of 3-D printing of patient specific scaffolds...
February 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/27771489/tailoring-biomaterial-scaffolds-for-osteochondral-repair
#2
Sandra Camarero-Espinosa, Justin Cooper-White
Articular cartilage is a mechanically and structurally complex, lubricious tissue that permits load-bearing and frictionless movement of our joints upon articulation. Unfortunately, cartilage is unable to properly self-heal as a result of acute trauma or damage, resulting in many cases in significant pain, reduction in physical activity and quality of life for the patient. Due to the inability of resident cells to repair damaged osteochondral tissue, researchers have focused on utilizing endogenously or exogenously sourced cells (chondrocytes or tissue-derived mesenchymal stem cells), with or without scaffolds, to encourage the secretion of extracellular matrix (ECM) that replicates this highly anisotropic osteochondral tissue, in which the phenotype of the cells and the composition and orientation of the ECM varies along its depth...
October 19, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27722242/periosteum-tissue-engineering-a-review
#3
Nanying Li, Juqing Song, Guanglin Zhu, Xiaoyu Li, Lei Liu, Xuetao Shi, Yingjun Wang
As always, the clinical therapy of critical size bone defects caused by trauma, tumor removal surgery or congenital malformation is facing great challenges. Currently, various approaches including autograft, allograft and cell-biomaterial composite based tissue-engineering strategies have been implemented to reconstruct injured bone. However, due to damage during the transplantation processes or design negligence of the bionic scaffolds, these methods expose vulnerabilities without the assistance of periosteum, a bilayer membrane on the outer surface of the bone...
October 18, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27663975/prevention-of-adhesions-in-the-temporomandibular-joint-by-the-use-of-chitosan-membrane-in-goats
#4
Hp Li, Sf Sun, Bt Fan, P Shen, Js Zheng, Sy Zhang
We evaluated the effects of chitosan membrane, a highly absorbable and viscous material, in the prevention of intra-articular adhesions after anchoring of the disc in the temporomandibular joints (TMJ) of six adult goats (12 joints). To simulate anterior displacement of the disc and TMJ trauma, we cut off the retrodiscal attachment and damaged the surface of the condylar bone, then randomly divided the goats into two groups: the control group (n=2) and the experimental group (n=4). In the experimental group we covered the condylar surfaces on both sides of the animals with chitosan membranes...
September 20, 2016: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27629763/angiogenic-potential-of-human-bone-marrow-derived-mesenchymal-stem-cells-in-chondrocyte-brick-enriched-constructs-promoted-stable-regeneration-of-craniofacial-cartilage
#5
Zhiye Li, Ruikai Ba, Zhifa Wang, Jianhua Wei, Yimin Zhao, Wei Wu
: : Craniofacial deformities caused by congenital defects or trauma remain challenges for clinicians, whereas current surgical interventions present limited therapeutic outcomes. Injection of bone marrow-derived mesenchymal stem cells (BMSCs) into the defect is highly desirable because such a procedure is microinvasive and grafts are more flexible to fill the lesions. However, preventing hypertrophic transition and morphological contraction remain significant challenges. We have developed an "all host derived" cell transplantation system composed of chondrocyte brick (CB)-enriched platelet-rich plasma (P) gel and BMSCs (B)...
September 14, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27617375/regenerative-endodontic-treatment-versus-apical-plug-in-immature-teeth-three-year-follow-up
#6
Saeed Asgary, Mahta Fazlyab, Ali Nosrat
This report compares and evaluates the treatment outcomes of regenerative endodontic treatment and apical plug as two accepted treatment protocols in a pair of necrotic immature maxillary central incisors of a 12-year old female. The patient was referred complaining of a dull pain and swelling in her upper lip area. She had a history of trauma to the anterior maxilla two years earlier. Both teeth were clinically diagnosed with pulp necrosis and periapical radiographs revealed that separate periapical radiolucent lesions surrounded the immature apices of both teeth...
2016: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27617188/strategies-and-first-advances-in-the-development-of-prevascularized-bone-implants
#7
Christoph Rücker, Holger Kirch, Oliver Pullig, Heike Walles
Despite the great regenerative potential of human bone, large bone defects are a serious condition. Commonly, large defects are caused by trauma, bone disease, malignant tumor removal, and infection or medication-related osteonecrosis. Large defects necessitate clinical treatment in the form of autologous bone transplantation or implantation of biomaterials as well as the application of other available methods that enhance bone defect repair. The development and application of prevascularized bone implants are closely related to the development animal models and require dedicated methods in order to reliably predict possible clinical outcomes and the efficacy of implants...
2016: Current Molecular Biology Reports
https://www.readbyqxmd.com/read/27612842/orbital-implants-state-of-the-art-review-with-emphasis-on-biomaterials-and-recent-advances
#8
REVIEW
Francesco Baino, Isabel Potestio
In the treatment of severe oculo-orbital traumas, intraocular malignancies or other life-threatening conditions it is sometimes necessary to surgically remove the patient's diseased eye. Following the removal of the eye, an orbital implant is inserted into the anophthalmic socket in order to provide satisfactory volume replacement and restore the aesthetic appearance of a normal eye. Over the last decades, the implant design and the criteria of materials selection evolved from simple non-porous polymeric sphere to devices with more complex shape and functionalities for ensuring better clinical outcomes in the long-term...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27599801/current-strategies-for-integrative-cartilage-repair
#9
Margaret K Boushell, Clark T Hung, Ernst B Hunziker, Eric J Strauss, Helen H Lu
Osteoarthritis (OA) is a degenerative joint condition characterized by painful cartilage lesions that impair joint mobility. Current treatments such as lavage, microfracture, and osteochondral implantation fail to integrate newly formed tissue with host tissues and establish a stable transition to subchondral bone. Similarly, tissue-engineered grafts that facilitate cartilage and bone regeneration are challenged by how to integrate the graft seamlessly with surrounding host cartilage and/or bone. This review centers on current approaches to promote cartilage graft integration...
September 6, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27598960/hallmarks-in-the-history-of-orthopaedic-implants-for-trauma-and-joint-replacement
#10
REVIEW
Konstantinos Markatos, Gregory Tsoucalas, Markos Sgantzos
This manuscript represents an attempt to review orthopaedic implants and reconstructive orthopaedic surgery for lower limbs lesions or trauma mainly in the 20th century. We emphasized on the type of implants, the biomaterials and their evolution, and we also engaged in a special reference for the pioneers of orthopaedic implant surgery and the innovative designers of those implants, in such a way to understand the ways and the stages through which they evolved to their present forms, as well as the scientific principles that affected their design and progress...
August 2016: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/27521494/novel-bioceramic-reinforced-hydrogel-for-alveolar-bone-regeneration
#11
Giorgio Iviglia, Clara Cassinelli, Elisa Torre, Francesco Baino, Marco Morra, Chiara Vitale-Brovarone
UNLABELLED: The osseointegration of dental implants and their consequent long-term success is guaranteed by the presence, in the extraction site, of healthy and sufficient alveolar bone. Bone deficiencies may be the result of extraction traumas, periodontal disease and infection. In these cases, placement of titanium implants is contraindicated until a vertical bone augmentation is obtained. This goal is achieved using bone graft materials, which should simulate extracellular matrix (ECM), in order to promote osteoblast proliferation and fill the void, maintaining the space without collapsing until the new bone is formed...
October 15, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27475528/combination-scaffolds-of-salmon-fibrin-hyaluronic-acid-and-laminin-for-human-neural-stem-cell-and-vascular-tissue-engineering
#12
Janahan Arulmoli, Heather J Wright, Duc T T Phan, Urmi Sheth, Richard A Que, Giovanni A Botten, Mark Keating, Elliot L Botvinick, Medha M Pathak, Thomas I Zarembinski, Daniel S Yanni, Olga V Razorenova, Christopher C W Hughes, Lisa A Flanagan
UNLABELLED: Human neural stem/progenitor cells (hNSPCs) are good candidates for treating central nervous system (CNS) trauma since they secrete beneficial trophic factors and differentiate into mature CNS cells; however, many cells die after transplantation. This cell death can be ameliorated by inclusion of a biomaterial scaffold, making identification of optimal scaffolds for hNSPCs a critical research focus. We investigated the properties of fibrin-based scaffolds and their effects on hNSPCs and found that fibrin generated from salmon fibrinogen and thrombin stimulates greater hNSPC proliferation than mammalian fibrin...
October 1, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27435965/injectable-gentamicin-loaded-thermo-responsive-hyaluronic-acid-derivative-prevents-infection-in-a-rabbit-model
#13
Gert-Jan A Ter Boo, Daniel Arens, Willem-Jan Metsemakers, Stephan Zeiter, R Geoff Richards, Dirk W Grijpma, David Eglin, T Fintan Moriarty
UNLABELLED: Despite the use of systemic antibiotic prophylaxis, the surgical fixation of open fractures with osteosynthesis implants is associated with high infection rates. Antibiotic-loaded biomaterials (ALBs) are increasingly used in implant surgeries across medical specialties to deliver high concentrations of antibiotics to the surgical site and reduce the risk of implant-associated infection. ALBs which are either less or not restricted in terms of spatial distribution and which may be applied throughout complex wounds could offer improved protection against infection in open fracture care...
October 1, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27424990/amniotic-fluid-stem-cells-an-ideal-resource-for-therapeutic-application-in-bone-tissue-engineering
#14
A Pantalone, I Antonucci, M Guelfi, P Pantalone, F G Usuelli, L Stuppia, V Salini
OBJECTIVE: Skeletal diseases, both degenerative and secondary to trauma, infections or tumors, represent an ideal target for regenerative medicine and in the last years, stem cells have been considered as good candidates for in vitro and in vivo bone regeneration. To date, several stem cell sources, such as adult mesenchymal stem cells, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), have shown significant osteogenic potential. MATERIALS AND METHODS: In this narrative review, we analyze the possible advantages of the use of AFSCs in the treatment of skeletal diseases, especially through the application of tissue engineering and biomaterials...
July 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27400843/controversies-in-the-management-of-the-trauma-patient
#15
REVIEW
Regina E Rodman, Robert M Kellman
Facial trauma is a significant cause of morbidity in the United States. Despite the large volume of trauma surgeries at most academic institutions, there is still controversy regarding management of many traumatic injuries. The literature lacks clear-cut best practices for most fractures. In orbital trauma, there is debate about the optimal timing of repair, preferred biomaterial to be used, and the utility of evaluation afterward with intraoperative computed tomographic scan. In repair of mandible fractures, there is debate regarding open versus closed reduction of subcondylar fractures, or alternatively, endoscopic repair...
August 2016: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/27334129/the-performance-of-bone-tissue-engineering-scaffolds-in-in%C3%A2-vivo-animal-models-a-systematic-review
#16
Marcos Ricardo Dantas Oliveira Ferraz de Misquita, Ricardo Bentini, Flavia Goncalves
Bone tissue engineering is an excellent alternative for the regeneration of large bone defects caused by trauma or bone pathologies. Scaffolds, stem cells, and bioactive molecules are the three key components of bone regeneration. Although a wide range of biomaterials of various compositions and structures has been proposed in the literature, these materials are rarely used in clinical applications. Therefore, more standardized studies are required to design scaffolds that enable better bone regeneration and are suitable for clinical use...
June 22, 2016: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/27284292/gs-dbm-pla-porous-composite-biomaterial-for-the-treatment-of-infective-femoral-condyle-defect-in-rats
#17
Xiaoming Liu, Lin Yang, Jing Li, Yuming Zhang, Weijun Xu, Yan Ren, Biwang Liu, Biao Yang, Baoxing Li
A bone defect resulting from open bone trauma may easily become infected; however, the administration of efficacious systemic antibiotics cannot be performed at safe levels. Previous studies have investigated anti-infective biomaterials that incorporate into bone and facilitate the direct application of high-concentration local antibiotics. In the present study, the effect of a novel porous composite with gentamicin sulfate (GS) in treating infected femoral condyle defects was investigated using a rat model...
June 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27249955/periprosthetic-joint-infection-in-hip-arthroplasty-is-there-an-association-between-infection-and-bearing-surface-type
#18
Rocco P Pitto, Laurent Sedel
BACKGROUND: Preliminary studies have raised the question of whether certain prosthetic biomaterials used in total hip arthroplasty (THA) bearings are associated with increased risk of periprosthetic joint infection (PJI). For example, some observational data suggest the risk of PJI is higher with metal-on-metal bearings. However, it is not known whether other bearings-including ceramic bearings or metal-on-polyethylene bearings-may be associated with a higher or lower risk of PJI. QUESTIONS/PURPOSES: The objective of this study was to use a national arthroplasty registry to assess whether the choice of bearings-metal-on-polyethylene (MoP), ceramic-on-polyethylene (CoP), ceramic-on-ceramic (CoC), or metal-on-metal (MoM)-is associated with differences in the risk of revision for deep infection, either (1) within 6 months or (2) over the entire period of observation, which spanned 15 years...
October 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27104930/evaluation-of-multi-scale-mineralized-collagen-polycaprolactone-composites-for-bone-tissue-engineering
#19
D W Weisgerber, K Erning, C L Flanagan, S J Hollister, B A C Harley
A particular challenge in biomaterial development for treating orthopedic injuries stems from the need to balance bioactive design criteria with the mechanical and geometric constraints governed by the physiological wound environment. Such trade-offs are of particular importance in large craniofacial bone defects which arise from both acute trauma and chronic conditions. Ongoing efforts in our laboratory have demonstrated a mineralized collagen biomaterial that can promote human mesenchymal stem cell osteogenesis in the absence of osteogenic media but that possesses suboptimal mechanical properties in regards to use in loaded wound sites...
August 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27079583/cartilage-tissue-engineering-from-biomaterials-and-stem-cells-to-osteoarthritis-treatments
#20
C Vinatier, J Guicheux
Articular cartilage is a non-vascularized and poorly cellularized connective tissue that is frequently damaged as a result of trauma and degenerative joint diseases such as osteoarthrtis. Because of the absence of vascularization, articular cartilage has low capacity for spontaneous repair. Today, and despite a large number of preclinical data, no therapy capable of restoring the healthy structure and function of damaged articular cartilage is clinically available. Tissue-engineering strategies involving the combination of cells, scaffolding biomaterials and bioactive agents have been of interest notably for the repair of damaged articular cartilage...
June 2016: Annals of Physical and Rehabilitation Medicine
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