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Yang and takayasu

Jiaxin Zhou, Zhe Chen, Jing Li, Yunjiao Yang, Jiuliang Zhao, Hu Chen, Min Liu, Fei Sun, Mengtao Li, Xinping Tian, Xiaofeng Zeng
OBJECTIVES: The aim of this study was to evaluate the efficacy and safety of tocilizumab (TCZ) in Chinese Takayasu's arteritis (TA) patients. METHODS: This was a single centre prospective study. Sixteen consecutive TA patients were included. Patients were treated with tocilizumab infusions with a dosage of 8mg/kg. Serum inflammation markers, including erythrocyte sedimentation rate (ESR) and hypersensitivity C reactive protein (hsCRP), were recorded at baseline and before each TCZ infusion...
April 10, 2017: Clinical and Experimental Rheumatology
Kun-Qi Yang, Yan-Kun Yang, Xu Meng, Ying Zhang, Hui-Min Zhang, Hai-Ying Wu, Ya-Xin Liu, Xiong-Jing Jiang, Jun Cai, Xian-Liang Zhou, Ru-Tai Hui, De-Yu Zheng, Li-Sheng Liu
BACKGROUND: Aortic dissection (AD) is a rare complication of Takayasu arteritis (TA). The clinical presentation and long-term management outcomes of AD in patients with TA have not been well described. MATERIALS AND METHODS: We conducted a retrospective study of patients with TA along with AD admitted to Fuwai Hospital between January 1985 and March 2016. Clinical data and follow-up data were collected and analyzed. RESULTS: Of the 1,154 patients with TA, we identified 10 patients (0...
April 2017: American Journal of the Medical Sciences
Yankun Yang, Tao Tian, Kunqi Yang, Ying Zhang, Xu Meng, Peng Fan, Lei Feng, Chaowei Mu, Linggen Gao, Xianliang Zhou
BACKGROUND: Coronary artery involvement is not a rare presentation of Takayasu arteritis (TA) and the treatment is challenging. The optimal methods of revascularization, and prognosis of treatment have not been established. OBJECTIVES: To assess the long-term outcomes of percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in TA patients. METHODS: Patients with coronary artery involved in TA who underwent either PCI or CABG were identified between February 2003 and December 2015...
February 13, 2017: International Journal of Cardiology
Wei Jiang, Yuanhua Yang, Xiuzhang Lv, Yidan Li, Zhanhong Ma, Jifeng Li
BACKGROUND: Up to 50% patients with Takayasu arteritis have pulmonary artery involvement. Hence, the early identification of pulmonary artery involvement to facilitate prompt treatment is required. METHODS: This retrospective study was performed in patients diagnosed with Takayasu arteritis between January 2009 and January 2016. Pulmonary artery involvement was confirmed with computed tomographic pulmonary angiography. Images from transthoracic echocardiography in three windows (suprasternal right pulmonary artery long-axis view, parasternal aortic short-axis view, and subxiphoid view) were documented and analyzed...
March 2017: Echocardiography
Jing Li, Yunjiao Yang, Jiuliang Zhao, Mengtao Li, Xinping Tian, Xiaofeng Zeng
To investigate the therapeutic effect of mycophenolate mofetil(MMF) on Chinese Takayasu's arteritis(TAK) patients. Thirty consecutive TAK outpatients were prospectively enrolled during 2013 to 2015. MMF combined with glucocorticoid was the primary treatment regimen. If clinical stable disease could not be reached, another traditional immunosuppressive agent could be added. All patients were evaluated and followed up every 3 months and vascular image studies by Doppler ultrasonography were repeated every 6 months...
December 7, 2016: Scientific Reports
Hui Dong, Wuqiang Che, Xiongjing Jiang, Meng Peng, Yubao Zou, Huimin Zhang, Bo Xu, Yuejin Yang, Runlin Gao
OBJECTIVES: Superficial femoral artery (SFA) involvement in Takayasu arteritis (TA) has rarely been reported. The purpose of this study was to investigate the clinical characteristic and clinical outcomes of endovascular therapy in such patients. METHODS: We analysed the data collected from 105 consecutive patients with TA, who were diagnosed from January 2011 to December 2013. All patients underwent ankle brachial index (ABI) measurements and angiography. Nine patients with an ABI <0...
November 18, 2016: Clinical and Experimental Rheumatology
P P Xia, S M Zhang, G Yang
No abstract text is available yet for this article.
September 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
Li-Li Pan, Juan Du, Na Gao, Hua Liao, Jin Wan, Wei-Ping Ci, Chun Yang, Tian Wang
Takayasu's arteritis (TAK) is a type of large vessel vasculitis which involves the aorta and its major branches. Interleukin (IL)-9 or IL-9-producing Th9 cells were found to be involved in pathogenesis of autoimmune arteritis such as giant cell arteritis, but IL-9 or Th9 cells in TAK were not well known. Here, this study aims to analyze the levels of serum IL-9 and their major source Th9 cells in TAK. With the help of cytometric bead array (CBA), a total of 21 patients with TAK were examined for serum levels of cytokines IL-4, IL-6, IL-8, IL-17, IL-10, TNF-α, IFN-γ, and IL-9...
December 2016: Clinical Rheumatology
J B Dou, J N Gong, Z H Ma, T G Kuang, Y H Yang
OBJECTIVE: To enhance the understanding of Takayasu's arteritis with pulmonary vascular involvement through the analyses on clinical features, imaging findings, misdiagnoses and treatments. METHODS: A retrospective study was conducted to analyze the clinical records of patients diagnosed as Takayasu's arteritis with pulmonary vascular involvement admitted to Beijing Chaoyang Hospital from January 2004 to December 2014. RESULTS: In recent 10 years, there were 90 patients diagnosed as Takayasu's arteritis in Beijing Chaoyang Hospital, 33 of them were involved with pulmonary arterial, which account for 36...
August 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
X F Kong, Z F Ji, L L Ma, X M Dai, Y Yan, H Y Chen, C D Yang, L Y Ma, S M Dai, L J Wu, L D Jiang
OBJECTIVE: This study aimed to analyze and evaluate the diagnostic efficacy of Ishikawa's, the modified Ishikawa's criteria, 1990 American College of Rheumatology (ACR ) classification criteria and the diagnostic model based on Chinese population in Chinese TA patients. METHODS: One hundred and forty-nine patients with Takayasu arteritis and 126 patients with other vascular disorders which involved aorta or its branches were recruited in this study.All the patients were admitted to the Department of rheumatism and Immunology clinic or inpatient department of Zhongshan Hospital affiliated to Fudan University from January 1(st), 2008 to June 31(st), 2015...
July 19, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
W H Xu, W J Guo, T S Yang
No abstract text is available yet for this article.
May 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
Fang Qin, Hu Wang, Lei Song, Xi-Li Lu, Li-Rui Yang, Er-Peng Liang, Wei Wang, Yu-Bao Zou, Jin Bian, Hai-Ying Wu, Xian-Liang Zhou, Ru-Tai Hui, Hui-Min Zhang, Xiong-Jing Jiang
BACKGROUND: Takayasu arteritis (TA) is a rare inflammatory arteriopathy of unknown etiology. The aim of this study was to investigate the genetic susceptibility to TA in a Chinese population. METHODS: Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rs10919543), and the HLA-B/MICA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014...
April 5, 2016: Chinese Medical Journal
Kun-Qi Yang, Yan-Kun Yang, Xu Meng, Ying Zhang, Xiong-Jing Jiang, Hai-Ying Wu, Hui-Min Zhang, Lei Song, Jin Bian, Dan Wen, Lin-Ping Wang, Xian-Liang Zhou
OBJECTIVE: The goal of this study was to investigate the relationship between polymorphisms in interleukin (IL)-12, IL-12R, IL-23, and IL-23R genes and Takayasu arteritis (TA) in a Chinese population. METHODS: A case-control study was performed to investigate the associations of 19 single nucleotide polymorphisms (SNPs) mapping to IL12A, IL12B, IL12RB1, IL12RB2 and IL23R with susceptibility to TA in 145 Chinese TA patients and 300 healthy controls. Genotype identification was performed with the MassARRAY system from Sequenom...
July 2016: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Andrew Yang, Mohammed Nayeemuddin, Bhanu Prasad
A 33-year-old Caucasian man was admitted to the hospital with chest pain and hypertensive urgency. Physical examination revealed widespread arterial bruits and marked difference in blood pressure between the upper limbs. Vascular imaging showed widespread narrowing in multiple vascular territories. He met the established American College of Rheumatology criteria for Takayasu's arteritis. His resistant hypertension was considered to be a consequence of bilateral renal artery stenosis and he subsequently underwent sequential stenting of his renal arteries leading to improvement in blood pressure and reduction in the number of antihypertensive medications...
January 18, 2016: BMJ Case Reports
Xiufang Kong, Ying Sun, Lili Ma, Huiyong Chen, Lei Wei, Wanlong Wu, Zongfei Ji, Lingying Ma, Zhuojun Zhang, Zhigang Zhang, Zhonghua Zhao, Jun Hou, Shengming Dai, Chengde Yang, Lindi Jiang
OBJECTIVES: To investigate T cell subsets and immune cytokine profiles in untreated Takayasu arteritis (TAK) patients and the underlying immunopathological mechanism. METHODS: We enrolled 50 untreated TAK patients and 40 age-matched controls (20 healthy controls, 20 untreated SLE patients). Enzyme-linked immunosorbent assays (ELISAs) were used to define cytokine profiles in all patients, and flow cytometry was performed for 9 TAK patients and 12 healthy controls...
May 2016: Clinical and Experimental Rheumatology
Lirui Yang, Huimin Zhang, Xiongjing Jiang, Lei Song, Fang Qin, Yubao Zou, Haiying Wu, Jin Bian, Xianliang Zhou, Rutai Hui, Deyu Zheng
OBJECTIVE: To describe the clinical features and longterm outcomes of patients with Takayasu arteritis (TA) in China who experienced neurological symptoms. METHODS: A retrospective study was undertaken of patients with TA who attended a single study center from 2002 to 2013, who also exhibited neurological symptoms (n = 274). Clinical and imaging features were analyzed, as well as longterm outcomes. RESULTS: The mean age at disease onset was 28...
October 2015: Journal of Rheumatology
Hua Yang
Takayasu arteritis (TA) is a chronic non-specific inflammatory vascular disease, of which the cause is not very clear. The disease is more severe in females. Furthermore, during the entire pregnancy, it is of great harm to the mother and child. The formation of blood clots is harmful to the mother and thrombosis is dangerous to the fetus and can lead to its death. Hence, prevention with control of perioperative hemodynamic changes during the pregnancy is an effective method to prevent heart failure, embolism, and thrombosis...
2015: Clinical and Experimental Obstetrics & Gynecology
M Peng, X-J Jiang, H Dong, Y-B Zou, H-M Zhang, L Song, B Li, Y-J Yang, H-Y Wu, R-L Gao, W-G Zhang, L-S Liu
Systematic investigation with large sample size of the distribution of etiologies of renal artery stenosis (RAS) is scant in both Western countries and China. We retrospectively analyzed the etiology of RAS in 2047 consecutive inpatients diagnosed with RAS for hypertension at Fuwai Hospital between 1999 and 2014. The number of patients with atherosclerosis was 1668 (81.5%), 259 (12.7%) with Takayasu's arteritis (TA), 86 (4.2%) with fibromuscular dysplasia (FMD), 34 (1.6%) with other causes. There was an obvious increase with age in the proportion of atherosclerotic RAS (P<0...
February 2016: Journal of Human Hypertension
B Chen, H X Yu, J Zhang, X X Li, X G Wu, S J Yang, Y X Qi, C Yan, Z G Wang
OBJECTIVES: Type I Takayasu arteritis is a progressive inflammatory disease involving the aortic arch and its main branches. If untreated, patients may develop a variety of serious conditions ranging from hemiplegia to death. Whilst there is a relatively strong evidence base for the outcome of surgical techniques, few reports have focused on revascularization using an endovascular technique in patients with Takayasu arteritis. METHODS: From May 2007 to March 2013, 11 consecutive patients with Takayasu arteritis presenting with severe cerebral ischemia symptoms caused by occlusive lesion in carotid artery underwent elective revascularization, 10 on the left carotid artery and 1 on the right...
May 2015: European Journal of Vascular and Endovascular Surgery
X Kong, L Ma, L Wu, H Chen, L Ma, Y Sun, W Wu, Z Ji, Z Zhang, C Yang, S Ye, S Chen, S Dai, Y Xue, G Qin, Y Zou, Q Yu, L Jiang
OBJECTIVES: Takayasu arteritis (TA) is a chronic granulomatous large-vessel vasculitis. When diagnosing TA, the criteria designed by the American College of Rheumatology (ACR) are used commonly but they were just classification criteria. There is an urgent need for a new set of diagnostic criteria. METHODS: One hundred and thirty-one TA patients and 132 control patients with other types of vascular disease were enrolled and both groups were distributed into a "training set" and a "validation set"...
March 2015: Clinical and Experimental Rheumatology
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