Silas A Buck, Sophie A Rubin, Tenzin Kunkhyen, Christoph D Treiber, Xiangning Xue, Lief E Fenno, Samuel J Mabry, Varun R Sundar, Zilu Yang, Divia Shah, Kyle D Ketchesin, Darius D Becker-Krail, Iaroslavna Vasylieva, Megan C Smith, Florian J Weisel, Wenjia Wang, M Quincy Erickson-Oberg, Emma I O'Leary, Eshan Aravind, Charu Ramakrishnan, Yoon Seok Kim, Yanying Wu, Matthias Quick, Jonathan A Coleman, William A MacDonald, Rania Elbakri, Briana R De Miranda, Michael J Palladino, Brian D McCabe, Kenneth N Fish, Marianne L Seney, Stephen Rayport, Susana Mingote, Karl Deisseroth, Thomas S Hnasko, Rajeshwar Awatramani, Alan M Watson, Scott Waddell, Claire E J Cheetham, Ryan W Logan, Zachary Freyberg
Parkinson's disease (PD) targets some dopamine (DA) neurons more than others. Sex differences offer insights, with females more protected from DA neurodegeneration. The mammalian vesicular glutamate transporter VGLUT2 and Drosophila ortholog dVGLUT have been implicated as modulators of DA neuron resilience. However, the mechanisms by which VGLUT2/dVGLUT protects DA neurons remain unknown. We discovered DA neuron dVGLUT knockdown increased mitochondrial reactive oxygen species in a sexually dimorphic manner in response to depolarization or paraquat-induced stress, males being especially affected...
October 3, 2023: bioRxiv