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https://www.readbyqxmd.com/read/28343344/simultaneous-detection-of-chlorinated-polycyclic-aromatic-hydrocarbons-with-polycyclic-aromatic-hydrocarbons-by-gas-chromatography-mass-spectrometry
#1
Meng Qiao, Wei Cao, Bochuan Liu, Xu Zhao, Jiuhui Qu
Chlorinated polycyclic aromatic hydrocarbons (ClPAHs), including polychlorinated naphthalenes (PCNs), are hazardous and widespread in the environment, but studies of these substances in the wastewater environment are lacking. In this study, five typical PCNs and five typical ClPAHs (other than PCNs) were simultaneously detected along with their parent polycyclic aromatic hydrocarbons in wastewater samples. All these compounds could be analyzed by gas chromatography- electron ionization mass spectrometry in selected ion monitoring mode and separated on a DB-17ms column...
March 25, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28343332/posterior-elements-disruption-with-hybrid-constructs-in-ais-patients-is-there-an-impact-on-proximal-junctional-kyphosis
#2
S Ghailane, Sebastien Pesenti, E Peltier, E Choufani, B Blondel, J L Jouve
PURPOSE: Proximal junctional kyphosis (PJK) is a frequent proximal adjacent segment disease following spinal fusion in adolescent idiopathic scoliosis (AIS) and its rate has been estimated to 28% in the literature. The etiology is multifactorial, and risk factors associated with PJK are controversial. The aim of this study was to demonstrate that the disruption of muscular and bony tissue above the upper instrumented vertebra (UIV) during surgery does not increase the rate of PJK in patients undergoing posterior fusion for adolescent idiopathic scoliosis...
March 25, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28343321/a-risk-score-based-on-admission-characteristics-to-predict-progressive-hemorrhagic-injury-from-traumatic-brain-injury-in-children
#3
Guo-Wen Hu, Hai-Li Lang, Hua Guo, Lei Wu, Pei Zhang, Wei Kuang, Xin-Gen Zhu
Traumatic brain injury (TBI) is one of the leading causes of death and disability in children, and progressive hemorrhagic injury (PHI) post TBI is associated with poor outcomes. Therefore, the objective of this study was to develop and validate a prognostic model that uses the information available at admission to determine the likelihood of PHI occurrence after TBI in children. The identified demographic data, cause of injury, clinical predictors on admission, computed tomography scan characteristics, and routine laboratory parameters were collected and used to develop a PHI prognostic model with logistic regression analysis, and the prediction model was validated in 68 children...
March 25, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28343316/translation-and-validation-of-iciq-fluts-for-tamil-speaking-women
#4
Chanil D Ekanayake, Arunasalam Pathmeswaran, A A Nilanga Nishad, Kanishka U Samaranayake, Prasantha S Wijesinghe
AIMS: Research in to lower urinary tract symptoms (LUTS) in women in South Asia is hampered by lack of validated tools. Our aim was to validate the International Consultation on Incontinence Modular Questionnaire on Female Lower Urinary Tract Symptoms (ICIQ-FLUTS) from English to Tamil. METHOD: After translation to Tamil, a validation study was carried out among women attending the gynecology clinic at District General Hospital-Mannar. RESULTS: Content validity assessed by the level of missing data was <2%...
March 25, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28343310/steroidogenic-genes-expressions-are-repressed-by-high-levels-of-leptin-and-the-jak-stat-signaling-pathway-in-ma-10-leydig-cells
#5
David A Landry, François Sormany, Josée Haché, Pauline Roumaud, Luc J Martin
The adipose tissue is an important endocrine organ secreting numerous peptide hormones, including leptin. Increased circulating levels of leptin, as a result of hormonal resistance in obese individuals, may contribute to lower androgen production in obese males. However, the molecular mechanisms involved need to be better defined. Androgens are mainly produced by Leydig cells within the testis. In male rodents, activation of the leptin receptor modulates a cascade of intracellular signal transduction pathways which may lead to regulation of transcription factors having influences on steroidogenesis in Leydig cells...
March 25, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28343308/the-nociceptive-withdrawal-response-of-the-foot-in-the-spinalized-rat-exhibits-limited-dependence-on-stimulus-location
#6
Corey L Cleland, Craig E Esquivel, Heath T Davis
The nociceptive withdrawal response (NWR) of the limb is a protective, multi-joint movement in response to noxious stimulation of the homonymous limb. Previous studies in animal models differed as to the dependence of the response direction and magnitude on stimulus location. The specific aim of our research was to use three-dimensional high-speed video to determine whether movement of the foot in response to heat stimuli delivered to the foot and lower leg depended on the location of the stimulus. In particular, we sought to determine whether the movement strategy was categorical or continuous...
March 25, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28343307/modular-organization-of-muscle-activity-patterns-in-the-leading-and-trailing-limbs-during-obstacle-clearance-in-healthy-adults
#7
Michael J MacLellan
Human locomotor patterns require precise adjustments to successfully navigate complex environments. Studies suggest that the central nervous system may control such adjustments through supraspinal signals modifying a basic locomotor pattern at the spinal level. To explore this proposed control mechanism in the leading and trailing limbs during obstructed walking, healthy young adults stepped over obstacles measuring 0.1 and 0.2 m in height. Unobstructed walking with no obstacle present was also performed as a baseline...
March 25, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28343297/association-of-the-cx3cr1-v249i-variant-with-neurofibrillary-pathology-progression-in-late-onset-alzheimer-s-disease
#8
Alan López-López, Ellen Gelpi, Diana Maria Lopategui, Jose M Vidal-Taboada
Neuroinflammation and microglial dysfunction have a prominent role in the pathogenesis of late-onset Alzheimer's disease (LOAD). CX3CR1 is a microglia-specific gene involved in microglia-neuron crosstalk and neuroinflammation. Numerous evidence show the involvement of CX3CR1 in AD. The aim of this study was to investigate if some functional genetic variants of this gene could influence on LOAD's outcome, in a neuropathologically confirmed Spanish cohort. We designed an open, pragmatic, case-control retrospective study including a total of 475 subjects (205 pathologically confirmed AD cases and 270 controls)...
March 25, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28343280/relationships-between-work-related-factors-and-musculoskeletal-health-with-current-and-future-work-ability-among-male-workers
#9
J S Boschman, A Noor, R Lundström, T Nilsson, J K Sluiter, M Hagberg
PURPOSE: The purpose was to increase job-specific knowledge about individual and work-related factors and their relationship with current and future work ability (WA). We studied cross-sectional relationships between mental demands, physical exertion during work, grip strength, musculoskeletal pain in the upper extremities and WA and the relationships between these variables and WA 11 years later. METHODS: We used a dataset of a prospective cohort study (1997-2008) among employees of an engineering plant (n = 157)...
March 25, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28343277/pancreatic-alpha-cell-selective-deletion-of-tcf7l2-impairs-glucagon-secretion-and-counter-regulatory-responses-to-hypoglycaemia-in-mice
#10
Gabriela da Silva Xavier, Angeles Mondragon, Vishnou Mourougavelou, Céline Cruciani-Guglielmacci, Jessica Denom, Pedro Luis Herrera, Christophe Magnan, Guy A Rutter
AIMS/HYPOTHESIS: Transcription factor 7-like 2 (TCF7L2) is a high mobility group (HMG) box-containing transcription factor and downstream effector of the Wnt signalling pathway. SNPs in the TCF7L2 gene have previously been associated with an increased risk of type 2 diabetes in genome-wide association studies. In animal studies, loss of Tcf7l2 function is associated with defective islet beta cell function and survival. Here, we explore the role of TCF7L2 in the control of the counter-regulatory response to hypoglycaemia by generating mice with selective deletion of the Tcf7l2 gene in pancreatic alpha cells...
March 25, 2017: Diabetologia
https://www.readbyqxmd.com/read/28343273/pharmacokinetic-comparison-of-cyclosporin-a-and-tacrolimus-in-graft-versus-host-disease-prophylaxis
#11
Ivan Sergeevich Moiseev, Ekaterina Andreevna Burmina, Albert Radikovich Muslimov, Olga Vladislavovna Pirogova, Sergey Nikolaevich Bondarenko, Elena Igorevna Darskaya, Yuliya Alexandrovna Tarakanova, Nadegda Georgievna Senina, Boris Vladimirovich Afanasyev
A number of studies were published with contradictory results comparing tacrolimus (Tac) and cyclosporine A (CsA) for graft-versus-host disease (GVHD) prophylaxis, but there are only few that accounted for pharmacokinetic (PK) parameters. In this study, we created a model based on median concentrations, variability of concentrations, and failures to maintain target levels that distinguished patients with low, intermediate, and high risks of acute GVHD (hazard ratios (HR) 1.77, 95%CI 1.36-2.32, p < 0.0001)...
March 25, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28343271/protein-degradation-systems-in-the-skeletal-muscles-of-parr-and-smolt-atlantic-salmon-salmo-salar-l-and-brown-trout-salmo-trutta-l
#12
Nadezda P Kantserova, Liudmila A Lysenko, Alexey E Veselov, Nina N Nemova
Although protein degradation limits the rate of muscle growth in fish, the role of proteolytic systems responsible for degrading myofibrillar proteins in skeletal muscle is not well defined. The study herein aims to evaluate the role of calpains (calcium-activated proteases) and proteasomes (ATP-dependent proteases) in mediating muscle protein turnover at different life stages in wild salmonids. Protease activities were estimated in Atlantic salmon (Salmo salar L.) and brown trout (Salmo trutta L.) parr and smolts from the Indera River (Kola Peninsula, Russia)...
March 26, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28343266/the-influence-of-general-health-on-the-need-for-dental-general-anaesthesia-in-children
#13
P Rajavaara, S Rankinen, M-L Laitala, H Vähänikkilä, H Yli-Urpo, S Koskinen, V Anttonen
AIM: To analyse the occurrence and causes of dental general anaesthesia (DGA) in healthy and medically compromised children, and to investigate if there are differences between those groups considering factors associated with DGA and DGA procedures. METHODS: The data was collected from medical records of children under 7 years of age treated under DGA in the years 2009 and 2010 at the Oulu University Hospital, Finland. The children were divided into two groups: 0-35-month-olds and ≥36-month olds...
March 25, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28343233/incidence-of-and-factors-influencing-femoral-neck-shortening-in-elderly-patients-after-fracture-fixation-with-multiple-cancellous-screws
#14
Xiaobing Chen, Jianzheng Zhang, Xiinling Wang, Jixin Ren, Zhi Liu
BACKGROUND To study the incidence of and factors influencing "neck shortening" in elderly patients treated for femoral neck fractures using multiple cancellous screws. MATERIAL AND METHODS Of the 197 femoral neck fracture cases treated via closed reduction and cancellous screws fixation from January 2006 to February 2010, 110 were followed up. Patient age, gender, operative time, implantation method, reduction quality, fracture type, bone mineral density, loading time, length of hospital stay, and Harris hip score 12 months after operation were recorded...
March 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28343232/genetic-polymorphisms-in-defb1-and-mirna202-are-involved-in-salivary-human-%C3%AE-defensin-1-levels-and-caries-experience-in-children
#15
Andrea Lips, Leonardo Santos Antunes, Lívia Azeredo Antunes, Júlia Guimarães Barcellos de Abreu, Driely Barreiros, Daniela Silva Barroso de Oliveira, Ana Carolina Batista, Paulo Nelson-Filho, Léa Assed Bezerra da Silva, Raquel Assed Bezerra da Silva, Gutemberg Gomes Alves, Erika Calvano Küchler
The antimicrobial peptides human β-defensins (hBDs) are encoded by β-defensin genes (DEFBs) and are possibly involved in caries susceptibility. In this study we aimed (1) to investigate the relationship between salivary hBDs and caries and (2) to evaluate the association of genetic polymorphisms in DEFB1 and microRNA202 (miRNA202) with salivary levels of hBDs and caries experience. Two data sets were available for this study, totalizing 678 Brazilian children. Dental examination and saliva collection were performed in all included children...
March 25, 2017: Caries Research
https://www.readbyqxmd.com/read/28343220/hemorrhagic-transformations-after-thrombectomy-risk-factors-and-clinical-relevance
#16
Johannes Kaesmacher, Mirjam Kaesmacher, Christian Maegerlein, Claus Zimmer, Alexandra S Gersing, Silke Wunderlich, Benjamin Friedrich, Tobias Boeckh-Behrens, Justus F Kleine
BACKGROUND: Hemorrhagic transformation (HT) is a major complication of acute ischemic stroke, potentially associated with clinical deterioration. We attempted to identify risk factors and evaluated clinical relevance of minor and major HTs following endovascular thrombectomy (ET) in isolated middle cerebral artery (MCA) occlusions. METHODS: This is a retrospective single-center analysis of 409 patients with isolated MCA occlusion treated with ET. Patients' and procedural characteristics, severity of HT according to the European Cooperative Acute Stroke Study criteria, and clinical outcomes were analyzed...
March 25, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28343219/simulation-based-training-in-flexible-bronchoscopy-and-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-ebus-tbna-a-systematic-review
#17
Therese Maria Henriette Naur, Philip Mørkeberg Nilsson, Pia Iben Pietersen, Paul Frost Clementsen, Lars Konge
BACKGROUND: The use of simulators in a training programme for technically challenging procedures has the advantages of lowering the risk of patient complications while helping the trainees with the initial part of their learning curve. OBJECTIVES: The aim of this study was to perform a systematic review of simulation-based training in flexible bronchoscopy and endobronchial ultrasound (EBUS). METHODS: We identified 1,006 publications in the PubMed database and included publications on flexible bronchoscopy below the carina and EBUS involving hands-on simulation-based training...
March 25, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28343213/gross-hematuria-is-more-common-in-male-and-older-patients-with-renal-tuberculosis-in-china-a-single-center-15-year-clinical-experience
#18
Yudong Cao, Yu Fan, Yuke Chen, Zheng Zhao, Yi Song, Cheng Shen, Xin Li, Haichao Huang, Wei Yu, Jie Jin
OBJECTIVES: This study aimed to investigate the clinical features of renal tuberculosis and identify the age- and gender-related differences. METHODS: A total of 419 patients at the Peking University First Hospital from January 2000 to July 2015 were retrospectively reviewed. Data on demographic characteristics, clinical presentation, complications, laboratory results, radiologic imaging, surgical procedures, and pathology features were collected and compared between genders and 3 different age groups (under 40 years, 41-60, years and over 60 years)...
March 25, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28343209/terminological-collocations-in-medical-latin-and-english-a-comparative-study
#19
Olena M Bieliaieva, Yuliia V Lysanets, Ivanna V Znamenska, Inesa V Rozhenko, Nataliia M Nikolaieva
INTRODUCTION: The present paper examines the linguistic status of terminological collocations in medical Latin and English, discusses the most productive term-formation models and ways of Latin-English translation. AIM: The authors aim to provide the comparative analysis of Latin and English terminological collocations and suggest their classification in terms of the idiomaticity level and semantic valency. MATERIALS AND METHODS: The research is based on the corpus of terminological collocations in Latin and English medical discourse using structural, etymological, typological, comparative methods, as well as the method of semantic analysis and conceptual metaphor theory...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28343193/role-of-genetic-mutations-in-development-of-immunological-and-clinical-disorders-in-children-with-chronic-pyelonephritis
#20
Vira P Harshman, Tetyana O Kryuchko, Iryna O Kolenko, Tetyana V Kushnereva, Olha Y Tkachenko
INTRODUCTION: At the present time, the study of mechanisms of recognition of foreign agents, which is realized by means of Toll-like receptors (TLR) of the innate immune system, has become one of the main tasks of clinical immunology. The aim of our study was to investigate the prevalence of polymorphism of Toll-like receptor 4 (Asp299Gly, Gly299Gly) among children with chronic pyelonephritis (CP) and determine the association of this TLR4 polymorphism with phenotypic features of chronic pyelonephritis and level of interleukin-6 (IL-6)...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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