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https://www.readbyqxmd.com/read/29353466/inter-observer-agreement-between-urologists-and-radiologists-in-interpreting-the-computed-tomography-images-of-emergency-patients-with-renal-colic
#1
Jun Young Hong, Dong Hoon Lee, In Ho Chang, Sung Bin Park, Chan Woong Kim, Byung Hoon Chi
PURPOSE: Low-dose non-enhanced computed tomography (LDCT) has been shown to provide low radiation exposure with proper diagnostic accuracy compared to standard dose non-enhanced computed tomography (SDCT) in patients with renal colic. The goal of our study is to estimate the accuracy of LDCT and SDCT interpretation by emergency medicine residents who primarily treated patients with renal colic. MATERIALS AND METHODS: Thirty sample images of both LDCT and SDCT from renal colic patients were extracted from January 2013 to December 2015 in a tertiary teaching hospital...
January 21, 2018: Urology Journal
https://www.readbyqxmd.com/read/29353451/analysis-of-circulating-mediators-of-bone-remodeling-in-prader-willi-syndrome
#2
G Brunetti, G Grugni, L Piacente, M Delvecchio, A Ventura, P Giordano, M Grano, G D'Amato, D Laforgia, A Crinò, M F Faienza
We tested the hypothesis that the levels of bone remodeling mediators may be altered in Prader-Willi syndrome (PWS). We assessed RANKL, OPG, sclerostin, DKK-1 serum levels, and bone metabolism markers in 12 PWS children (7.8 ± 4.3 years), 14 PWS adults (29.5 ± 7.2 years), and 31 healthy controls matched for sex and age. Instrumental parameters of bone mineral density (BMD) were also evaluated. Lumbar spine BMD Z-scores were reduced in PWS children (P < 0.01), reaching osteopenic levels in PWS adults...
January 20, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29353449/blastulation-timing-is-associated-with-differential-mitochondrial-content-in-euploid-embryos
#3
Jacqueline R Ho, Nabil Arrach, Katherine Rhodes-Long, Wael Salem, Lynda K McGinnis, Karine Chung, Kristin A Bendikson, Richard J Paulson, Ali Ahmady
PURPOSE: Preimplantation genetic screening (PGS) and assessment of mitochondrial content (MC) are current methods for selection of the best embryos for transfer. Studies suggest that time-lapse morphokinetics (TLM) may also be helpful for selecting embryos more likely to implant. In our study, we sought to examine the relationship between TLM parameters and MC to determine if they could be used adjunctively in embryo selection. We also examined the relationship between MC with ploidy and blastulation...
January 20, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29353440/healthy-lifestyle-promotion-in-primary-schools-through-the-board-game-kaledo-a-pilot-cluster-randomized-trial
#4
Emanuela Viggiano, Alessandro Viggiano, Anna Di Costanzo, Adela Viggiano, Andrea Viggiano, Eleonora Andreozzi, Vincenzo Romano, Claudia Vicidomini, Daniela Di Tuoro, Giuliana Gargano, Lucia Incarnato, Celeste Fevola, Pietro Volta, Caterina Tolomeo, Giuseppina Scianni, Caterina Santangelo, Maria Apicella, Roberta Battista, Maddalena Raia, Ilaria Valentino, Marianna Palumbo, Giovanni Messina, Antonietta Messina, Marcellino Monda, Bruno De Luca, Salvatore Amaro
The board game Kaledo was proven to be effective in improving nutrition knowledge and in modifying dietary behavior in students attending middle and high school. The present pilot study aims to reproduce these results in younger students (7-11 years old) attending primary school. A total of 1313 children from ten schools were recruited to participate in the present study. Participants were randomized into two groups: (1) the treatment group which consisted of playing Kaledo over 20 sessions and (2) the no intervention group...
January 20, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29353439/transgenesis-by-microparticle-bombardment-for-live-imaging-of-fluorescent-proteins-in-pristionchus-pacificus-germline-and-early-embryos
#5
Satoshi Namai, Asako Sugimoto
Pristionchus pacificus is a free-living nematode used as a model organism for evolutionary developmental and ecological biology. Although a transgenic technique to form complex arrays by microinjection has been established in P. pacificus, transgene expression from the array in the germline and early embryos tends to be silenced. Here, we established a method to integrate transgenes into the genome of P. pacificus using microparticle bombardment with hygromycin B selection. Additionally, we isolated a mutant exhibiting significantly lower autofluorescence in the germline and early embryos, facilitating visualization of transgene-derived fluorescent proteins for live imaging...
January 20, 2018: Development Genes and Evolution
https://www.readbyqxmd.com/read/29353434/prediction-of-progression-in-skull-base-meningiomas-additional-benefits-of-apparent-diffusion-coefficient-value
#6
Ching-Chung Ko, Sher-Wei Lim, Tai-Yuan Chen, Jeon-Hor Chen, Chien-Feng Li, Yow-Ling Shiue
A subset of benign (WHO grade I) skull base meningiomas show early progression/recurrence (P/R) in the first years after surgical resection. Besides, complete surgical resection may be difficult to achieve safely in skull base meningiomas due to complex neurovascular structures. The one main challenge in the treatment of skull base meningiomas is to determine factors that correlate with P/R. We retrospectively investigated the preoperative CT and MR imaging features for the prediction of P/R in skull base meningiomas, with emphasis on quantitative ADC values...
January 20, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29353433/recent-trends-and-analytical-challenges-in-plant-bioactive-peptide-separation-identification-and-validation
#7
REVIEW
Susy Piovesana, Anna Laura Capriotti, Chiara Cavaliere, Giorgia La Barbera, Carmela Maria Montone, Riccardo Zenezini Chiozzi, Aldo Laganà
Interest in research into bioactive peptides (BPs) is growing because of their health-promoting ability. Several bioactivities have been ascribed to peptides, including antioxidant, antihypertensive and antimicrobial properties. As they can be produced from precursor proteins, the investigation of BPs in foods is becoming increasingly popular. For the same reason, production of BPs from by-products has also emerged as a possible means of reducing waste and recovering value-added compounds suitable for functional food production and supplements...
January 20, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29353429/a-sensitive-method-using-spme-pre-concentration-for-the-quantification-of-aromatic-amines-in-indoor-air
#8
Vincent Lucaire, Jean-Jacques Schwartz, Olivier Delhomme, Ruben Ocampo-Torres, Maurice Millet
Monitoring the levels of aliphatic and aromatic amines (AA) in indoor air is important to protect human health because of exposure to these compounds through diet and inhalation. A sampling and analytical method using XAD-2 cartridges and gas chromatography coupled to mass spectrometry used for assessing 25 AA in different smoking and non-smoking indoor environment was developed. After sampling and delivering 1 m3 of air (6-8 h sampling), an adsorbent was ultrasonically extracted with acetonitrile, concentrated to 1 mL and diluted in 25 mL of water (pH = 9; 5% NaCl), and then extracted for 40 min at 80 °C using a divinylbenzene/carboxen/polydimethylsiloxane (DVB/CAR/PDMS) fiber and injected in a GC/MS system...
January 20, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29353404/dna-methylation-rather-than-single-nucleotide-polymorphisms-regulates-the-production-of-an-aberrant-splice-variant-of-il6r-in-mastitic-cows
#9
Yan Zhang, Xiuge Wang, Qiang Jiang, Haisheng Hao, Zhihua Ju, Chunhong Yang, Yan Sun, Changfa Wang, Jifeng Zhong, Jinming Huang, Huabin Zhu
Interleukin-6 receptor-alpha (IL6R) interacts with IL6 and forms a ligand-receptor complex, which can stimulate various cellular responses, such as cell proliferation, cell differentiation, and activation of inflammatory processes. Both genetic mutation and epigenetic modification regulate gene transcription. We identified a novel splice variant of bovine IL6R, designated as IL6R-TV, which is characterized by the skipping of exon 2 of the NCBI-referenced IL6R gene (IL6R-reference). The expression levels of IL6R-TV and IL6R-reference transcripts were lower in normal mammary gland tissues...
January 20, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29353401/temporal-analysis-of-factors-associated-with-eat-10-in-outpatients-with-oropharyngeal-dysphagia-from-a-tertiary-care-clinic
#10
R S Bartlett, J E Moore, S L Thibeault
Self-perception of disease is increasingly recognized as a determinant of health. The Eating Assessment Tool-10 (EAT-10) is a functional health status questionnaire that measures the symptomatic severity of dysphagia from the patient's perspective. The objective of this work was to identify factors (demographics, clinical variables, swallowing physiology, health-related quality of life) associated with longitudinal change in EAT-10 scores in outpatients with oropharyngeal dysphagia at a multi-disciplinary, tertiary care clinic...
January 20, 2018: Dysphagia
https://www.readbyqxmd.com/read/29353395/comparison-of-osteoporosis-in-us-adults-with-type-1-and-type-2-diabetes-mellitus
#11
S C DeShields, T D Cunningham
PURPOSE: We examined bone mineral density (BMD) and osteoporosis prevalence in those with type 1 compared to type 2 diabetes derived from a nationally representative sample from the civilian community in the United States. METHODS: Data from the National Health and Nutrition Examination Survey (NHANES) for 2005-2006, 2007-2008, 2009-2010, and 2013-2014 were merged to obtain a large sample of diabetics at least 20 years of age with participation in the interview and medical examination...
January 20, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29353387/inter-individual-variation-in-health-and-disease-associated-with-pulmonary-infectious-agents
#12
Kirsten C Verhein, Heather L Vellers, Steven R Kleeberger
Respiratory infectious diseases resulting from bacterial or viral pathogens such as Mycobacterium tuberculosis, Streptococcus pneumoniae, respiratory syncytial virus (RSV), or influenza, are major global public health concerns. Lower respiratory tract infections are leading causes of morbidity and mortality, only behind ischemic heart disease and stroke (GBD 2015 LRI Collaborators in Lancet Infect Dis 17(11):1133-1161, 2017). Developing countries are particularly impacted by these diseases. However, while many are infected with viruses such as RSV (> 90% of all individuals are infected by age 2), only sub-populations develop severe disease...
January 20, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29353379/coagulase-negative-staphylococci-are-associated-to-the-mild-inflammatory-pattern-of-healthcare-associated-meningitis-a-retrospective-study
#13
S Couffin, D Lobo, F Cook, P H Jost, V Bitot, R Birnbaum, B Nebbad, B Aït-Mamar, W Lahiani, M Martin, G Dhonneur, R Mounier
The epidemiology of healthcare-associated meningitis (HAM) is dominated by commensal bacteria from the skin, as coagulase-negative staphylococci (CoNS). We hypothesized that the pauci-symptomatic and mild inflammatory patterns of HAM are related to the low pathogenic state of CoNS. Our aim was to describe clinical and biological features of CoNS HAM, compared to other HAM. All consecutive patients with HAM admitted in our hospital were retrospectively included from 2007 to 2014. HAM due to CoNS were compared to HAM caused by other bacteria (controls) for clinical and laboratory patterns...
January 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29353376/injury-prevention-in-baseball-from-youth-to-the-pros
#14
REVIEW
Heath P Melugin, Nels D Leafblad, Christopher L Camp, Stan Conte
PURPOSE OF REVIEW: This review examines recent literature on injury epidemiology and prevention in the sport of baseball from youth to professional levels. RECENT FINDINGS: Overuse is the predominant mechanism of injury in youth baseball players. Newer stretching and exercise protocols may help prevent these injuries. At the professional level, however, overuse has not been proven to correlate with increased injury incidence, but pitch counts are still monitored...
January 20, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29353367/surveillance-for-cancer-recurrence-in-long-term-young-breast-cancer-survivors-randomly-selected-from-a-statewide-cancer-registry
#15
Tarsha Jones, Debra Duquette, Meghan Underhill, Chang Ming, Kari E Mendelsohn-Victor, Beth Anderson, Kara J Milliron, Glenn Copeland, Nancy K Janz, Laurel L Northouse, Sonia M Duffy, Sofia D Merajver, Maria C Katapodi
PURPOSE: This study examined clinical breast exam (CBE) and mammography surveillance in long-term young breast cancer survivors (YBCS) and identified barriers and facilitators to cancer surveillance practices. METHODS: Data collected with a self-administered survey from a statewide, randomly selected sample of YBCS diagnosed with invasive breast cancer or ductal carcinoma in situ younger than 45 years old, stratified by race (Black vs. White/Other). Multivariate logistic regression models identified predictors of annual CBEs and mammograms...
January 20, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29353350/clinical-pharmacokinetics-and-pharmacodynamics-of-evolocumab-a-pcsk9-inhibitor
#16
REVIEW
Sreeneeranj Kasichayanula, Anita Grover, Maurice G Emery, Megan A Gibbs, Ransi Somaratne, Scott M Wasserman, John P Gibbs
Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases plasma low-density lipoprotein cholesterol (LDL-C) by decreasing expression of the LDL receptor on hepatic cells. Evolocumab is a human monoclonal immunoglobulin G2 that binds specifically to human PCSK9 to reduce LDL-C. Evolocumab exhibits nonlinear kinetics as a result of binding to PCSK9. Elimination is predominantly through saturable binding to PCSK9 at lower concentrations and a nonsaturable proteolytic pathway at higher concentrations. The effective half-life of evolocumab is 11-17 days...
January 20, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29353337/a-retrospective-analysis-of-5-fluorouracil-plus-cisplatin-as-first-line-chemotherapy-in-the-recent-treatment-strategy-for-patients-with-metastatic-or-recurrent-esophageal-squamous-cell-carcinoma
#17
Shuji Hiramoto, Ken Kato, Hirokazu Shoji, Natsuko Okita, Atsuo Takashima, Yoshitaka Honma, Satoru Iwasa, Tetsuya Hamaguchi, Yasuhide Yamada, Yasuhiro Shimada, Narikazu Boku
BACKGROUND: Patients with metastatic or recurrent esophageal squamous cell carcinoma (ESCC) have a poor prognosis. For decades, the most widely used first-line chemotherapy regimen for these patients has been the combination of 5-fluorouracil + cisplatin (CF). However, prognostic factors of CF as first-line chemotherapy for ESCC have not been clarified. METHODS: A total of 187 patients with metastatic or recurrent esophageal ESCC treated with CF at the National Cancer Center Hospital between January 2001 and December 2012 were enrolled in the study...
January 20, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29353328/serum-uric-acid-levels-are-associated-with-lupus-nephritis-in-patients-with-normal-renal-function
#18
Ana Luisa Calich, Eduardo Ferreira Borba, Michelle Remião Ugolini-Lopes, Luiza Fuoco da Rocha, Eloisa Bonfá, Ricardo Fuller
Uric acid has been recognised as a potential marker of endothelial dysfunction and kidney disease but there are scarce data about its importance in systemic lupus erythematosus (SLE) nephritis. This study aimed to evaluate serum uric acid (UA) levels in lupus nephritis (LN), by comparing SLE patients with normal renal function, with and without nephritis. Forty-six female SLE patients were consecutively selected and divided in two groups according to renal activity at the evaluation: presence of a recently diagnosed lupus nephritis (LN+, n = 18) and absence of lupus nephritis (LN-, n = 28)...
January 20, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29353327/transforaminal-endoscopic-decompression-for-thoracic-spinal-stenosis-under-local-anesthesia
#19
REVIEW
Zhi-Qiang Jia, Xi-Jing He, Li-Tao Zhao, San-Qiang Li
BACKGROUND: Thoracic spinal stenosis is a common vertebral degenerative disease, and treatment remains challenging. In recent years, transforaminal endoscopic decompression has been widely used for treating lumbar degenerative diseases. However, the efficacy of this procedure for thoracic spinal stenosis has yet to be established. Herein, we report a case of thoracic spinal stenosis treated with transforaminal endoscopic decompression under local anesthesia. CASE REPORT: An 88-year-old man presented with a 1-month history of progressive paralysis and dysesthesia in the bilateral lower extremities...
January 20, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29353292/harm-reduction-program-use-psychopathology-and-medical-severity-in-patients-with-methadone-maintenance-treatment
#20
Nieves Gudelia Martínez-Luna, Laia Rodríguez-Cintas, Abderraman Esojo, Raúl Felipe Palma-Álvarez, María Robles-Martínez, Lara Grau-López, Marta Perea, Carlos Roncero
Methadone maintenance programs (MMP) for opioid dependence treatment have been widely used due to their effective therapeutic outcomes. Harm reduction programs (HRP) are complementary programs for severe patients with high risk behaviors and when abstinence is not possible. This study aims to compare patients in MMP that use HRP (MMP-HRP) and patients in MMP who do not use HRP (MMP-NO HRP). The sample was composed of 143 patients (MMP-HRP = 42 vs. MMP-NO HRP = 101). An additional subanalysis was performed with patients under 45 years of age (n = 116; MMP-HRP = 38 vs...
January 15, 2018: Adicciones
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