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Endothelial cells nutrition

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https://www.readbyqxmd.com/read/29627677/preparation-of-high-bioactivity-multilayered-bone-marrow-mesenchymal-stem-cell-sheet-for-myocardial-infarction-using-a-3d-dynamic-system
#1
Yingwei Wang, Jianhua Zhang, Zixi Qin, Zepei Fan, Cheng Lu, Baoxin Chen, Jupeng Zhao, Xiaojuan Li, Fei Xiao, Xi Lin, Zheng Wu
Cell sheet techniques offer a promising future for myocardial infarction (MI) therapy; however, insufficient nutrition supply remains the major limitation in maintaining stem cell bioactivities in vitro. In order to enhance cell sheet mechanical strength and bioactivities, a decellularized porcine pericardium (DPP) scaffold was prepared by the phospholipase A2 method, and aspartic acid was used as a spacer arm to improve the vascular endothelial growth factor crosslink efficiency on the DPP scaffold. Based on this scaffold, multilayered bone marrow mesenchymal stem cell sheets were rapidly constructed, using RAD16-I peptide hydrogel as a temporary 3D scaffold, and cell sheets were cultured in either the 3D-dynamic system (DCcs) or the traditional static condition (SCcs)...
April 5, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29626449/vascular-endothelial-growth-factor-vegf-a-and-fibroblast-growth-factor-fgf-2-as-potential-regulators-of-seasonal-reproductive-processes-in-male-european-bison-bison-bonasus-linnaeus-1758
#2
Anna Tabecka-Lonczynska, Jennifer Mytych, Przemyslaw Solek, Magdalena Kulpa-Greszta, Magdalena Sowa-Kucma, Marek Koziorowski
Growth factors: vascular endothelial growth factor A (VEGF-A) and fibroblast growth factor (FGF-2) were reported to affect normal physiological reproductive processes in human, domestic and free living animals. Moreover, some reports suggest that VEGF-A and FGF-2 may be directly involved in the control of the annual reproductive cycle of seasonally breeding animals but detailed knowledge is still missing. Our study aimed to demonstrate the expression of mRNA and protein for both factors in the tissues of testis and epididymis (caput, corpus, cauda) at different periods of the year (March, June, November, December) in European bison as a model of seasonally breeding animal...
April 4, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29615674/acute-metabolic-actions-of-the-major-polyphenols-in-chamomile-an-in-vitro-mechanistic-study-on-their-potential-to-attenuate-postprandial-hyperglycaemia
#3
Jose A Villa-Rodriguez, Asimina Kerimi, Laszlo Abranko, Sarka Tumova, Lauren Ford, Richard S Blackburn, Christopher Rayner, Gary Williamson
Transient hyperglycaemia is a risk factor for type 2 diabetes and endothelial dysfunction, especially in subjects with impaired glucose tolerance. Nutritional interventions and strategies for controlling postprandial overshoot of blood sugars are considered key in preventing progress to the disease state. We have identified apigenin-7-O-glucoside, apigenin, and (Z) and (E)-2-hydroxy-4-methoxycinnamic acid glucosides as the active (poly)phenols in Chamomile (Matricaria recutita) able to modulate carbohydrate digestion and absorption in vitro as assessed by inhibition of α-amylase and maltase activities...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29557255/neural-mechanisms-of-inflammation-induced-fever
#4
Anders Blomqvist, David Engblom
Fever is a common symptom of infectious and inflammatory disease. It is well-established that prostaglandin E2 is the final mediator of fever, which by binding to its EP3 receptor subtype in the preoptic hypothalamus initiates thermogenesis. Here, we review the different hypotheses on how the presence of peripherally released pyrogenic substances can be signaled to the brain to elicit fever. We conclude that there is unequivocal evidence for a humoral signaling pathway by which proinflammatory cytokines, through their binding to receptors on brain endothelial cells, evoke fever by eliciting prostaglandin E2 synthesis in these cells...
March 1, 2018: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/29542837/testicular-development-in-male-lambs-prenatally-exposed-to-a-high-starch-diet
#5
Francesca Mossa, Daniela Bebbere, Antonello Ledda, Giovanni P Burrai, Imane Chebli, Elisabetta Antuofermo, Sergio Ledda, Antonello Cannas, Francesco Fancello, Alberto S Atzori
Maternal nutrition during critical gestation periods impacts on offspring in later life; effects of high-starch maternal diet on testicular development in lambs were addressed. Dairy ewes were fed diets providing either 27% (Starch, S) or 11% (Fiber, F) of starch from mating to lambing (∼147 days; S147, F147) or for the last 75 days of gestation (S75, F75). Testes of single male lambs were measured and then sampled for histological and gene expression analyses at selected ages. Testicular dimensions and weight were similar among groups, but the total area of seminiferous tubules increased with age and tended to be higher (P = 0...
March 15, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29535992/developmental-programming-of-renal-function-and-re-programming-approaches
#6
REVIEW
Eva Nüsken, Jörg Dötsch, Lutz T Weber, Kai-Dietrich Nüsken
Chronic kidney disease affects more than 10% of the population. Programming studies have examined the interrelationship between environmental factors in early life and differences in morbidity and mortality between individuals. A number of important principles has been identified, namely permanent structural modifications of organs and cells, long-lasting adjustments of endocrine regulatory circuits, as well as altered gene transcription. Risk factors include intrauterine deficiencies by disturbed placental function or maternal malnutrition, prematurity, intrauterine and postnatal stress, intrauterine and postnatal overnutrition, as well as dietary dysbalances in postnatal life...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29510402/oxymatrine-inhibits-homocysteine-mediated-autophagy-via-mif-mtor-signaling-in-human-umbilical-vein-endothelial-cells
#7
Yanyan Zhang, Yuan Zhang, Jiayu Tang, Shuang Zhao, Chen Li, Yong-Pan Huang, Minhan Yi
BACKGROUND/AIMS: Genetic or nutritional deficiencies in homocysteine (Hcy)metabolism lead to the accumulation of Hcy and its metabolites in the blood. This can lead to hyperhomocysteinemia (HHcy), which is an independent risk factor for cardiovascular disease. Studies have shown that HHcy leads to endothelial dysfunction, a hallmark of atherosclerosis, which may explain this link. The precise mechanism remains unclear, but a strong possibility is excessive HHCy-induced autophagy. Autophagy has been better studied in ischemia/reperfusion (I/R) injuries, and previous work showed that Oxymatrine (OMT), a quinolizidine alkaloid, protects cells against myocardial I/R injury by inhibiting autophagy...
February 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29465424/nutritional-approach-to-preeclampsia-prevention
#8
Najate Achamrah, Agnès Ditisheim
PURPOSE OF REVIEW: Although not fully understood, the physiopathology of preeclampsia is thought to involve an abnormal placentation, diffuse endothelial cell dysfunction and increased systemic inflammation. As micronutrients play a key role in placental endothelial function, oxidative stress and expression of angiogenic factors, periconceptional micronutrient supplementation has been proposed to reduce the risk of preeclampsia. However, recent studies reported conflicting results. RECENT FINDINGS: Calcium intake (>1 g/day) may reduce the risk of preeclampsia in women with low-calcium diet...
May 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29454997/regulatory-responses-of-hepatocytes-macrophages-and-vascular-endothelial-cells-to-magnesium-deficiency
#9
Mei Shigematsu, Shozo Tomonaga, Fumie Shimokawa, Masaru Murakami, Toru Imamura, Tohru Matsui, Masayuki Funaba
The liver is the organ that responds to nutritional disturbances including magnesium deficiency. The present study evaluated cellular responses to magnesium deficiency using model cells of the liver, namely, HepG2 cells as hepatocytes, RAW264.7 cells as Kupffer cells and human umbilical vein endothelial cells (HUVECs) as vascular endothelial cells; we examined effects of culture with magnesium deficient medium on cell responses in individual types of cells as well as interactive responses among cells. Metabolomic analyses indicated that magnesium deficiency differentially affected the cellular content of metabolites among HepG2 cells, RAW264...
February 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29452238/human-adipose-tissue-derived-stromal-cells-in-combination-with-exogenous-stimuli-facilitate-three-dimensional-network-formation-of-human-endothelial-cells-derived-from-various-sources
#10
Dominique Manikowski, Birgit Andrée, Esther Samper, Clémence Saint-Marc, Ruth Olmer, Peter Vogt, Sarah Strauß, Axel Haverich, Andres Hilfiker
In natural tissues, the nutrition of cells and removal of waste products is facilitated by a dense capillary network which is generated during development. This perfusion system is also indispensable for tissue formation in vitro. Nutrition depending solely on diffusion is not sufficient to generate tissues of clinically relevant dimensions, which is a core aim in tissue engineering research. In this study, the establishment of a vascular network was investigated in a self-assembling approach employing endothelial and mural cells...
February 13, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29348256/flavonoids-dairy-foods-and-cardiovascular-and-metabolic-health-a-review-of-emerging-biologic-pathways
#11
REVIEW
Dariush Mozaffarian, Jason H Y Wu
A growing body of nutritional science highlights the complex mechanisms and pleiotropic pathways of cardiometabolic effects of different foods. Among these, some of the most exciting advances are occurring in the area of flavonoids, bioactive phytochemicals found in plant foods; and in the area of dairy, including milk, yogurt, and cheese. Many of the relevant ingredients and mechanistic pathways are now being clarified, shedding new light on both the ingredients and the pathways for how diet influences health and well-being...
January 19, 2018: Circulation Research
https://www.readbyqxmd.com/read/29316680/effect-of-low-molecular-weight-oligopeptides-isolated-from-sea-cucumber-on-diabetic-wound-healing-in-db-db-mice
#12
Di Li, Lin Li, Teng Xu, Tianxing Wang, Jinwei Ren, Xinran Liu, Yong Li
Impaired wound healing is a major clinical problem in patients with diabetes and is the leading cause of lower limb amputation. This study is aimed to observe the effects of small molecule oligopeptides isolated from sea cucumber (SCCOPs) on the wound healing process in diabetic mice. Ninety db/db male mice were divided into five groups, including the model control group, whey protein group (0.50 g/kg) and three SCCOPs dose groups (0.25 g/kg, 0.50 g/kg and 1.00 g/kg). Additionally, 18 db/m male mice were used as normal control group...
January 8, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29219948/asperosaponin-vi-promotes-angiogenesis-and-accelerates-wound-healing-in-rats-via-up-regulating-hif-1%C3%AE-vegf-signaling
#13
Cheng-Gui Wang, Yi-Ting Lou, Min-Ji Tong, Li-Lian Zhang, Zeng-Jie Zhang, Yong-Zeng Feng, Shi Li, Hua-Zi Xu, Cong Mao
Wound therapy remains a clinical challenge due to the complexity of healing pathology and high demand of achieving functional and aesthetically satisfactory scars. Newly formed blood vessels are essential for tissue repair since they can support cells at the wound site with nutrition and oxygen. In this study, we investigated the effects of Asperosaponin VI (ASA VI) isolated from a traditional Chinese medicine, the root of Dipsacus asper Wall, in promoting angiogenesis, as well as its function in wound therapeutics...
March 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29167060/aging-process-adherence-to-mediterranean-diet-and-nutritional-status-in-a-large-cohort-of-nonagenarians-effects-on-endothelial-progenitor-cells
#14
F Cesari, F Sofi, R Molino Lova, F Vannetti, G Pasquini, F Cecchi, R Marcucci, A M Gori, C Macchi
BACKGROUND AND AIM: Adherence to the Mediterranean Diet (MD) has been associated with a longer and better life. The aim of this study was to examine the effects of adherence to the MD, and of nutritional habits on endothelial progenitor (EPCs) and circulating progenitor (CPCs) cells in a cohort of nonagenarians enrolled within the Mugello Study, an epidemiological study aimed at investigating both clinically relevant geriatric items and various health issues, including those related to nutritional status...
January 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29118911/fibroblast-growth-factor-21-delayed-endothelial-replicative-senescence-and-protected-cells-from-h-2-o-2-induced-premature-senescence-through-sirt1
#15
Jinhua Yan, Jinli Wang, Huijin Huang, Yi Huang, Tao Mi, Cuntai Zhang, Le Zhang
Vascular aging is an independent risk factor for age-related diseases, including atherosclerosis. Fibroblast growth factor 21 (FGF21) has been widely recognized as a metabolic regulator that is elevated in response to caloric and nutritional restrictions. Recent studies have demonstrated its emerging role as a pro-longevity hormone, but its effects on the senescence of human umbilical vascular endothelial cells (HUVECs) remain unclear. In the present study, we explored the anti-senescence effects and underlying mechanism of FGF21 on HUVECs...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29112161/collateral-damage-intended-cancer-associated-fibroblasts-and-vasculature-are-potential-targets-in-cancer-therapy
#16
REVIEW
Ana Cavaco, Maryam Rezaei, Stephan Niland, Johannes A Eble
After oncogenic transformation, tumor cells rewire their metabolism to obtain sufficient energy and biochemical building blocks for cell proliferation, even under hypoxic conditions. Glucose and glutamine become their major limiting nutritional demands. Instead of being autonomous, tumor cells change their immediate environment not only by their metabolites but also by mediators, such as juxtacrine cell contacts, chemokines and other cytokines. Thus, the tumor cells shape their microenvironment as well as induce resident cells, such as fibroblasts and endothelial cells (ECs), to support them...
November 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29081352/development-of-the-hyaloid-choroidal-and-retinal-vasculatures-in-the-fetal-human-eye
#17
REVIEW
Gerard A Lutty, D Scott McLeod
The development of the ocular vasculatures is perfectly synchronized to provide the nutritional and oxygen requirements of the forming human eye. The fetal vasculature of vitreous, which includes the hyaloid vasculature, vasa hyaloidea propria, and tunica vasculosa lentis, initially develops around 4-6 weeks gestation (WG) by hemo-vasculogenesis (development of blood and blood vessels from a common progenitor, the hemangioblast). This transient fetal vasculature expands around 12 WG by angiogenesis (budding from primordial vessels) and remains until a retinal vasculature begins to form...
January 2018: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29056905/hyperhomocysteinemia-suppressed-immunity-and-altered-oxidative-metabolism-caused-by-pathogenic-microbes-in-atherosclerosis-and-dementia
#18
REVIEW
Kilmer S McCully
Many pathogenic microorganisms have been demonstrated in atherosclerotic plaques and in cerebral plaques in dementia. Hyperhomocysteinemia, which is a risk factor for atherosclerosis and dementia, is caused by dysregulation of methionine metabolism secondary to deficiency of the allosteric regulator, adenosyl methionine. Deficiency of adenosyl methionine results from increased polyamine biosynthesis by infected host cells, causing increased activity of ornithine decarboxylase, decreased nitric oxide and peroxynitrate formation and impaired immune reactions...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29052437/5-6-dehydrokawain-from-the-rhizome-of-alpinia-mutica-roxb-induced-proangiogenic-tumour-derived-vegf-of-ht-29-colorectal-cancer
#19
Ibrahim Malami, Aliyu Muhammad, Ibrahim B Abubakar, Imaobong C Etti, Peter M Waziri, Ramadan M Abubakar, Halilu E Mshelia
Vascular endothelial growth factor (VEGF) is a glycoprotein vital to the regulation of vascular endothelial cells proliferation, migration and angiogenesis. The expression of VEGF is required for the formation of new blood vessels critical in supplying oxygen and nutrition in the course of tumorigenesis. The present study investigated the effect of 5,6-dehydrokawain isolated from the rhizomes of Alpinia mutica on VEGF expression in vitro using HT-29 cell line. The results revealed that 5,6-dehydrokawain induced the expression of proangiogenic tumour-derived VEGF of HT-29 cells, which may explain the inability of 5,6-dehydrokawain in suppressing cancer cells proliferation...
October 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29048643/novel-transduction-of-nutrient-stress-to-notch-pathway-by-rasgrp3-promotes-malignant-aggressiveness-in-human-esophageal-squamous-cell-carcinoma
#20
Ge Hu, Yuepeng Zhou, Yu Zhu, Ling Zhou, Rui Ling, Dan Wu, Lei Mi, Xuefeng Wang, Dongfang Dai, Chaoming Mao, Deyu Chen
In the process of enlarging of tumors, the dissolving tissue structures and remodeling endothelial cells for restoring gas exchange and nutritional support, further facilitate tumor cell invasion and metastasis. Activation of Ras plays a critical role in the development of esophageal squamous cell carcinoma (ESCC), but the underlying mechanisms remain poorly understood. We therefore investigated whether Ras guanyl-releasing protein 3 (RasGRP3), a Ras activator, could promote metastasis by inducing vascular regeneration and further epithelial-mesenchymal transition under nutrient stress (NS)...
September 25, 2017: Oncology Reports
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