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Endothelial cells nutrition

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https://www.readbyqxmd.com/read/27900024/acute-effect-of-lactic-acid-on-tumor-endothelial-cell-metabolic-coupling-in-the-tumor-microenvironment
#1
Guanqun Zhu, Degui Wang, Shenqian Li, Xuecheng Yang, Yanwei Cao, Yonghua Wang, Haitao Niu
The present study aimed to systematically analyze alterations in the expression of mitochondrial-associated proteins in human bladder cancer T24 cells co-cultured with tumor-associated human umbilical vein endothelial cells (HUVECs), and to investigate the characteristics of bladder cancer cell energy metabolism. The present study used the following techniques: A co-culture system of T24 cells and HUVECs was constructed using a microfluidic chip as a 3D co-culture system; the concentration of lactic acid in the medium of the cells was determined using an automatic microplate reader; a qualitative analysis of mitochondria-associated protein expression was performed by immunofluorescent staining; and a quantitative analysis of mitochondrial-associated protein expression was conducted using western blotting...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899720/luteal-function-during-the-estrous-cycle-in-arginine-treated-ewes-fed-different-planes-of-nutrition
#2
Casie S Bass, Dale A Redmer, Samantha L Kaminski, Anna T Grazul-Bilska
Corpus luteum (CL) functions are influenced by numerous factors including hormones, growth and angiogenic factors, nutritional plane, and dietary supplements such as arginine (Arg), a semi-essential amino acid and precursor for proteins, polyamines, and nitric oxide (NO). The aim of this study was to determine if Arg supplementation to ewes fed different planes of nutrition impacts 1) progesterone (P4) concentrations in serum and luteal tissue, 2) luteal vascularity, cell proliferation, endothelial NO synthase (eNOS), and receptor (R) soluble guanylate cyclase β protein and mRNA expression, and 3) luteal mRNA expression for selected angiogenic factors during the estrous cycle...
November 29, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27852870/biological-activities-of-extracellular-vesicles-and-their-cargos-from-bovine-and-human-milk-in-humans-and-implications-for-infants
#3
REVIEW
Janos Zempleni, Ana Aguilar-Lozano, Mahrou Sadri, Sonal Sukreet, Sonia Manca, Di Wu, Fang Zhou, Ezra Mutai
Extracellular vesicles (EVs) in milk harbor a variety of compounds, including lipids, proteins, noncoding RNAs, and mRNAs. Among the various classes of EVs, exosomes are of particular interest, because cargo sorting in exosomes is a regulated, nonrandom process and exosomes play essential roles in cell-to-cell communication. Encapsulation in exosomes confers protection against enzymatic and nonenzymatic degradation of cargos and provides a pathway for cellular uptake of cargos by endocytosis of exosomes. Compelling evidence suggests that exosomes in bovine milk are transported by intestinal cells, vascular endothelial cells, and macrophages in human and rodent cell cultures, and bovine-milk exosomes are delivered to peripheral tissues in mice...
November 16, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27794111/schwann-cell-and-endothelial-cell-damage-in-transthyretin-familial-amyloid-polyneuropathy
#4
Haruki Koike, Shohei Ikeda, Mie Takahashi, Yuichi Kawagashira, Masahiro Iijima, Yohei Misumi, Yukio Ando, Shu-Ichi Ikeda, Masahisa Katsuno, Gen Sobue
OBJECTIVE: To examine the morphology of Schwann cells and endoneurial microvessels with electron microscopy. METHODS: Sural nerve biopsy specimens from 49 patients with familial amyloid polyneuropathy (FAP) with transthyretin Val30Met mutation were assessed. Patients included 11 early-onset cases from endemic foci and 38 late-onset cases from nonendemic areas. RESULTS: Loss of nerve fibers with or without neighboring amyloid deposition was a common feature...
October 28, 2016: Neurology
https://www.readbyqxmd.com/read/27785087/adiponectin-treatment-attenuates-inflammatory-response-during-early-sepsis-in-obese-mice
#5
XianFeng Wang, Nancy L Buechler, Barbara K Yoza, Charles E McCall, Vidula Vachharajani
BACKGROUND: Morbid obesity increases the cost of care in critically ill patients. Sepsis is the leading cause of death in noncoronary intensive care units. Circulating cell-endothelial cell interactions in microcirculation are the rate-determining factors in any inflammation; obesity increases these interactions further. Adiponectin deficiency is implicated in increased cardiovascular risk in obese patients. We have shown that adiponectin deficiency increases microvascular dysfunction in early sepsis...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27753812/ssa-04-3-leptin-adiponectin-in-cardiometabolic-disease
#6
Patricio Lopez-Jaramillo
Cardiovascular diseases (CVD) are major causes of death and illness worldwide. In recent decades an increased prevalence of CVD mortality has been reported in low-medium income countries, which has been associated with changes in life styles, deficiencies in health systems and the persistence of social inequities.The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin resistance and increased adiposity as its central features. Identifying individuals with metabolic syndrome is important due to its association with an increased risk of coronary heart disease and type 2 diabetes mellitus (DM2)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27733522/inorganic-nitrate-supplementation-in-young-and-old-obese-adults-does-not-affect-acute-glucose-and-insulin-responses-but-lowers-oxidative-stress
#7
Ammar W Ashor, Shakir Chowdhury, Clio Oggioni, Othman Qadir, Kirsten Brandt, Abbas Ishaq, John C Mathers, Gabriele Saretzki, Mario Siervo
BACKGROUND: Aging and obesity are associated with raised oxidative stress and a reduction of nitric oxide (NO) bioavailability, with subsequent decline in insulin sensitivity and endothelial function. Inorganic nitrate is converted into NO via a 2-step reduction process and may be an effective nutritional intervention to modify vascular and metabolic functions. OBJECTIVES: This study tested whether inorganic nitrate supplementation improved glucose disposal and attenuated the acute effects of hyperglycemia on oxidative stress, inflammation, and vascular function in young and old obese participants...
November 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27643352/ssa-04-3-leptin-adiponectin-in-cardiometabolic-disease
#8
Patricio Lopez-Jaramillo
Cardiovascular diseases (CVD) are major causes of death and illness worldwide. In recent decades an increased prevalence of CVD mortality has been reported in low-medium income countries, which has been associated with changes in life styles, deficiencies in health systems and the persistence of social inequities.The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin resistance and increased adiposity as its central features. Identifying individuals with metabolic syndrome is important due to its association with an increased risk of coronary heart disease and type 2 diabetes mellitus (DM2)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27542820/vegf-expression-is-regulated-by-hif-1%C3%AE-and-arnt-in-3d-kyse-70-esophageal-cancer-cell-spheroids
#9
Jun Terashima, Satoko Sampei, Mei Iidzuka, Ayumi Ohsakama, Chie Tachikawa, Junya Satoh, Kenzo Kudo, Wataru Habano, Shogo Ozawa
In 3D cultured cell systems, the cells form 3D spheroids that mimic cancer cell spheroids in vivo. Cancer cells form cell spheroids as they grow. The in vivo spheroids do not contain a vascular network; therefore, oxygen and nutrition supplies are insufficient. Specifically, the cells in the core region of the cluster are exposed to higher stress levels than the cells in the outer spheroid layer. As a result, the cells in the spheroid are exposed to low nutrition and hypoxia conditions. To overcome these shortages, angiogenesis is induced in cancer spheroids in vivo...
November 2016: Cell Biology International
https://www.readbyqxmd.com/read/27502989/sirolimus-therapy-for-patients-with-lymphangioleiomyomatosis-leads-to-loss-of-chylous-ascites-and-circulating-lam-cells
#10
Sergio Harari, Davide Elia, Olga Torre, Elisabetta Bulgheroni, Elena Provasi, Joel Moss
A young woman received a diagnosis of abdominal, sporadic lymphangioleiomyomatosis (LAM) and multiple abdominal lymphangioleiomyomas and was referred for recurrent chylous ascites responding only to a fat-free diet. On admission, pulmonary function test (PFT) results showed a moderate reduction in the transfer factor for carbon monoxide with normal exercise performance. The serum vascular endothelial growth factor D (VEGF-D) level was 2,209 pg/mL. DNA sequences, amplified at loci kg8, D16S3395, D16S3024, D16S521, and D16S291 on chromosome 16p13...
August 2016: Chest
https://www.readbyqxmd.com/read/27464716/pharmaceutical-targeting-of-the-brain
#11
István A Krizbai, Ádám Nyúl-Tóth, Hans-Christian Bauer, Attila E Farkas, Andreas Traweger, János Haskó, Hannelore Bauer, Imola Wilhelm
Besides being indispensable for the protection and nutrition of the central nervous system (CNS), blood-brain barrier (BBB)-forming cerebral endothelial cells (CECs) have a major role in hampering drugs to reach therapeutically relevant concentrations in the brain. In this respect, the most important defense systems of CECs are tight junctions (TJs) sealing the paracellular way of transport, efflux pumps (ABC transporters) and metabolic enzymes. Here we review current strategies aiming at overcoming the BBB with the purpose of effectively delivering drugs to the CNS...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27420646/intact-endothelial-and-contractile-function-of-coronary-artery-after-8%C3%A2-hours-of-heart-preservation
#12
Guangqi Qin, Trygve Sjöberg, Qiuming Liao, Xiaoke Sun, Stig Steen
OBJECTIVES: The aim of the study was to investigate if adequate preservation of coronary artery endothelium-dependent relaxation and contractility may be obtained after 8 hours of non-ischemic heart preservation. DESIGN: Porcine hearts were perfused for 8 hours at 8 °C, either in cycles of 15 minutes perfusion and 60 minutes non-perfusion, or by continuous perfusion. The perfusate consisted of a cardioplegic, hyperoncotic nutrition solution with oxygenated red cells, and the perfusion pressure was 20 mmHg...
August 3, 2016: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/27399127/intradialytic-aerobic-cycling-exercise-alleviates-inflammation-and-improves-endothelial-progenitor-cell-count-and-bone-density-in-hemodialysis-patients
#13
Min-Tser Liao, Wen-Chih Liu, Fu-Huang Lin, Ching-Feng Huang, Shao-Yuan Chen, Chuan-Chieh Liu, Shih-Hua Lin, Kuo-Cheng Lu, Chia-Chao Wu
Inflammation, endothelial dysfunction, and mineral bone disease are critical factors contributing to morbidity and mortality in hemodialysis (HD) patients. Physical exercise alleviates inflammation and increases bone density. Here, we investigated the effects of intradialytic aerobic cycling exercise on HD patients. Forty end-stage renal disease patients undergoing HD were randomly assigned to either an exercise or control group. The patients in the exercise group performed a cycling program consisting of a 5-minute warm-up, 20 minutes of cycling at the desired workload, and a 5-minute cool down during 3 HD sessions per week for 3 months...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27247335/novel-biomarkers-to-improve-the-prediction-of-cardiovascular-event-risk-in-type-2-diabetes-mellitus
#14
Joep van der Leeuw, Joline W J Beulens, Susan van Dieren, Casper G Schalkwijk, Jan F C Glatz, Marten H Hofker, W M Monique Verschuren, Jolanda M A Boer, Yolanda van der Graaf, Frank L J Visseren, Linda M Peelen, Yvonne T van der Schouw
BACKGROUND: We evaluated the ability of 23 novel biomarkers representing several pathophysiological pathways to improve the prediction of cardiovascular event (CVE) risk in patients with type 2 diabetes mellitus beyond traditional risk factors. METHODS AND RESULTS: We used data from 1002 patients with type 2 diabetes mellitus from the Second Manifestations of ARTertial disease (SMART) study and 288 patients from the European Prospective Investigation into Cancer and Nutrition-NL (EPIC-NL)...
June 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27117476/body-composition-nutritional-status-and-endothelial-function-in-physically-active-men-without-metabolic-syndrome-a-25-year-cohort-study
#15
Małgorzata Pigłowska, Tomasz Kostka, Wojciech Drygas, Anna Jegier, Joanna Leszczyńska, Mirosława Bill-Bielecka, Magdalena Kwaśniewska
BACKGROUND: The purpose of this analysis was to investigate the relationship between body composition, metabolic parameters and endothelial function among physically active healthy middle-aged and older men. METHODS: Out of 101 asymptomatic men prospectively tracked for traditional cardiovascular risk factors (mean observation period 25.1 years), 55 metabolically healthy individuals who maintained stable leisure time physical activity (LTPA) level throughout the observation and agreed to participate in the body composition assessment were recruited (mean age 60...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27105528/sh003-represses-tumor-angiogenesis-by-blocking-vegf-binding-to-vegfr2
#16
Hyeong Sim Choi, Min Kyoung Kim, Kangwook Lee, Kang Min Lee, Youn Kyung Choi, Yong Cheol Shin, Sung-Gook Cho, Seong-Gyu Ko
Tumor angiogenesis is a key feature of cancer progression, because a tumor requires abundant oxygen and nutrition to grow. Here, we demonstrate that SH003, a mixed herbal extract containing Astragalus membranaceus (Am), Angelica gigas (Ag) and Trichosanthes Kirilowii Maximowicz (Tk), represses VEGF-induced tumor angiogenesis both in vitro and in vivo. SH003 inhibited VEGF-induced migration, invasion and tube formation in human umbilical vein endothelial cells (HUVEC) with no effect on the proliferation. SH003 reduced CD31-positive vessel numbers in tumor tissues and retarded tumor growth in our xenograft mouse tumor model, while SH003 did not affect pancreatic tumor cell viability...
May 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/27053136/cohort-profile-the-german-diabetes-study-gds
#17
Julia Szendroedi, Aaruni Saxena, Katharina S Weber, Klaus Strassburger, Christian Herder, Volker Burkart, Bettina Nowotny, Andrea Icks, Oliver Kuss, Dan Ziegler, Hadi Al-Hasani, Karsten Müssig, Michael Roden
BACKGROUND: The German Diabetes Study (GDS) is a prospective longitudinal cohort study describing the impact of subphenotypes on the course of the disease. GDS aims at identifying prognostic factors and mechanisms underlying the development of related comorbidities. STUDY DESIGN AND METHODS: The study comprises intensive phenotyping within 12 months after clinical diagnosis, at 5-year intervals for 20 years and annual telephone interviews in between. Dynamic tests, including glucagon, mixed meal, intravenous glucose tolerance and hyperinsulinemic clamp tests, serve to assess beta-cell function and tissue-specific insulin sensitivity...
2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27052787/cd142-cd61-cd146-and-cd45-microparticles-predict-cardiovascular-events-in-high-risk-patients-following-a-mediterranean-diet-supplemented-with-nuts
#18
Gemma Chiva-Blanch, Javier Crespo, Rosa Suades, Gemma Arderiu, Teresa Padro, Gemma Vilahur, Judith Cubedo, Dolores Corella, Jordi Salas-Salvadó, Fernando Arós, Miguel-Angel Martínez-González, Emilio Ros, Montse Fitó, Ramon Estruch, Lina Badimon
Circulating microparticles (cMPs) are small phospholipid-rich microvesicles shed by activated cells that play a pivotal role in cell signalling related to the pathogenesis of atherothrombosis. We aimed to investigate the prognostic value of cMPs released from different vascular cells for cardiovascular event (CVE) presentation in asymptomatic patients at high cardiovascular risk factors under nutritional and pharmacologic treatment. This is a nested case-control study of 50 patients from the five-year follow-up prospective PREDIMED trial enrolled in the nuts arm of the Mediterranean diet (MedDiet-nuts)...
July 4, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27012748/hormetic-and-regulatory-effects-of-lipid-peroxidation-mediators-in-pancreatic-beta-cells
#19
REVIEW
Giuseppe Maulucci, Bareket Daniel, Ofir Cohen, Yossef Avrahami, Shlomo Sasson
Nutrient sensing mechanisms of carbohydrates, amino acids and lipids operate distinct pathways that are essential for the adaptation to varying metabolic conditions. The role of nutrient-induced biosynthesis of hormones is paramount for attaining metabolic homeostasis in the organism. Nutrient overload attenuate key metabolic cellular functions and interfere with hormonal-regulated inter- and intra-organ communication, which may ultimately lead to metabolic derangements. Hyperglycemia and high levels of saturated free fatty acids induce excessive production of oxygen free radicals in tissues and cells...
June 2016: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/26967562/dsgost-inhibits-tumor-growth-by-blocking-vegf-vegfr2-activated-angiogenesis
#20
Hyeong Sim Choi, Kangwook Lee, Min Kyoung Kim, Kang Min Lee, Yong Cheol Shin, Sung-Gook Cho, Seong-Gyu Ko
Tumor growth requires a process called angiogenesis, a new blood vessel formation from pre-existing vessels, as newly formed vessels provide tumor cells with oxygen and nutrition. Danggui-Sayuk-Ga-Osuyu-Saenggang-Tang (DSGOST), one of traditional Chinese medicines, has been widely used in treatment of vessel diseases including Raynaud's syndrome in Northeast Asian countries including China, Japan and Korea. Therefore, we hypothesized that DSGOST might inhibit tumor growth by targeting newly formed vessels on the basis of its historical prescription...
April 19, 2016: Oncotarget
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