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Endothelial cells nutrition

Ammar W Ashor, Shakir Chowdhury, Clio Oggioni, Othman Qadir, Kirsten Brandt, Abbas Ishaq, John C Mathers, Gabriele Saretzki, Mario Siervo
BACKGROUND: Aging and obesity are associated with raised oxidative stress and a reduction of nitric oxide (NO) bioavailability, with subsequent decline in insulin sensitivity and endothelial function. Inorganic nitrate is converted into NO via a 2-step reduction process and may be an effective nutritional intervention to modify vascular and metabolic functions. OBJECTIVES: This study tested whether inorganic nitrate supplementation improved glucose disposal and attenuated the acute effects of hyperglycemia on oxidative stress, inflammation, and vascular function in young and old obese participants...
October 12, 2016: Journal of Nutrition
Patricio Lopez-Jaramillo
Cardiovascular diseases (CVD) are major causes of death and illness worldwide. In recent decades an increased prevalence of CVD mortality has been reported in low-medium income countries, which has been associated with changes in life styles, deficiencies in health systems and the persistence of social inequities.The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin resistance and increased adiposity as its central features. Identifying individuals with metabolic syndrome is important due to its association with an increased risk of coronary heart disease and type 2 diabetes mellitus (DM2)...
September 2016: Journal of Hypertension
Jun Terashima, Satoko Sampei, Mei Iidzuka, Ayumi Ohsakama, Chie Tachikawa, Junya Satoh, Kenzo Kudo, Wataru Habano, Shogo Ozawa
In 3D cultured cell systems, the cells form 3D spheroids that mimic cancer cell spheroids in vivo. Cancer cells form cell spheroids as they grow. The in vivo spheroids do not contain a vascular network; therefore, oxygen and nutrition supplies are insufficient. Specifically, the cells in the core region of the cluster are exposed to higher stress levels than the cells in the outer spheroid layer. As a result, the cells in the spheroid are exposed to low nutrition and hypoxia conditions. To overcome these shortages, angiogenesis is induced in cancer spheroids in vivo...
November 2016: Cell Biology International
Sergio Harari, Davide Elia, Olga Torre, Elisabetta Bulgheroni, Elena Provasi, Joel Moss
A young woman received a diagnosis of abdominal, sporadic lymphangioleiomyomatosis (LAM) and multiple abdominal lymphangioleiomyomas and was referred for recurrent chylous ascites responding only to a fat-free diet. On admission, pulmonary function test (PFT) results showed a moderate reduction in the transfer factor for carbon monoxide with normal exercise performance. The serum vascular endothelial growth factor D (VEGF-D) level was 2,209 pg/mL. DNA sequences, amplified at loci kg8, D16S3395, D16S3024, D16S521, and D16S291 on chromosome 16p13...
August 2016: Chest
István A Krizbai, Ádám Nyúl-Tóth, Hans-Christian Bauer, Attila E Farkas, Andreas Traweger, János Haskó, Hannelore Bauer, Imola Wilhelm
Besides being indispensable for the protection and nutrition of the central nervous system (CNS), blood-brain barrier (BBB)-forming cerebral endothelial cells (CECs) have a major role in hampering drugs to reach therapeutically relevant concentrations in the brain. In this respect, the most important defense systems of CECs are tight junctions (TJs) sealing the paracellular way of transport, efflux pumps (ABC transporters) and metabolic enzymes. Here we review current strategies aiming at overcoming the BBB with the purpose of effectively delivering drugs to the CNS...
July 26, 2016: Current Pharmaceutical Design
Guangqi Qin, Trygve Sjöberg, Qiuming Liao, Xiaoke Sun, Stig Steen
OBJECTIVES: The aim of the study was to investigate if adequate preservation of coronary artery endothelium-dependent relaxation and contractility may be obtained after 8 hours of non-ischemic heart preservation. DESIGN: Porcine hearts were perfused for 8 hours at 8°C, either in cycles of 15 minutes perfusion and 60 minutes non-perfusion, or by continuous perfusion. The perfusate consisted of a cardioplegic, hyperoncotic nutrition solution with oxygenated red cells, and the perfusion pressure was 20 mmHg...
July 15, 2016: Scandinavian Cardiovascular Journal: SCJ
Min-Tser Liao, Wen-Chih Liu, Fu-Huang Lin, Ching-Feng Huang, Shao-Yuan Chen, Chuan-Chieh Liu, Shih-Hua Lin, Kuo-Cheng Lu, Chia-Chao Wu
Inflammation, endothelial dysfunction, and mineral bone disease are critical factors contributing to morbidity and mortality in hemodialysis (HD) patients. Physical exercise alleviates inflammation and increases bone density. Here, we investigated the effects of intradialytic aerobic cycling exercise on HD patients. Forty end-stage renal disease patients undergoing HD were randomly assigned to either an exercise or control group. The patients in the exercise group performed a cycling program consisting of a 5-minute warm-up, 20 minutes of cycling at the desired workload, and a 5-minute cool down during 3 HD sessions per week for 3 months...
July 2016: Medicine (Baltimore)
Joep van der Leeuw, Joline W J Beulens, Susan van Dieren, Casper G Schalkwijk, Jan F C Glatz, Marten H Hofker, W M Monique Verschuren, Jolanda M A Boer, Yolanda van der Graaf, Frank L J Visseren, Linda M Peelen, Yvonne T van der Schouw
BACKGROUND: We evaluated the ability of 23 novel biomarkers representing several pathophysiological pathways to improve the prediction of cardiovascular event (CVE) risk in patients with type 2 diabetes mellitus beyond traditional risk factors. METHODS AND RESULTS: We used data from 1002 patients with type 2 diabetes mellitus from the Second Manifestations of ARTertial disease (SMART) study and 288 patients from the European Prospective Investigation into Cancer and Nutrition-NL (EPIC-NL)...
June 2016: Journal of the American Heart Association
Małgorzata Pigłowska, Tomasz Kostka, Wojciech Drygas, Anna Jegier, Joanna Leszczyńska, Mirosława Bill-Bielecka, Magdalena Kwaśniewska
BACKGROUND: The purpose of this analysis was to investigate the relationship between body composition, metabolic parameters and endothelial function among physically active healthy middle-aged and older men. METHODS: Out of 101 asymptomatic men prospectively tracked for traditional cardiovascular risk factors (mean observation period 25.1 years), 55 metabolically healthy individuals who maintained stable leisure time physical activity (LTPA) level throughout the observation and agreed to participate in the body composition assessment were recruited (mean age 60...
2016: Lipids in Health and Disease
Hyeong Sim Choi, Min Kyoung Kim, Kangwook Lee, Kang Min Lee, Youn Kyung Choi, Yong Cheol Shin, Sung-Gook Cho, Seong-Gyu Ko
Tumor angiogenesis is a key feature of cancer progression, because a tumor requires abundant oxygen and nutrition to grow. Here, we demonstrate that SH003, a mixed herbal extract containing Astragalus membranaceus (Am), Angelica gigas (Ag) and Trichosanthes Kirilowii Maximowicz (Tk), represses VEGF-induced tumor angiogenesis both in vitro and in vivo. SH003 inhibited VEGF-induced migration, invasion and tube formation in human umbilical vein endothelial cells (HUVEC) with no effect on the proliferation. SH003 reduced CD31-positive vessel numbers in tumor tissues and retarded tumor growth in our xenograft mouse tumor model, while SH003 did not affect pancreatic tumor cell viability...
May 31, 2016: Oncotarget
Julia Szendroedi, Aaruni Saxena, Katharina S Weber, Klaus Strassburger, Christian Herder, Volker Burkart, Bettina Nowotny, Andrea Icks, Oliver Kuss, Dan Ziegler, Hadi Al-Hasani, Karsten Müssig, Michael Roden
BACKGROUND: The German Diabetes Study (GDS) is a prospective longitudinal cohort study describing the impact of subphenotypes on the course of the disease. GDS aims at identifying prognostic factors and mechanisms underlying the development of related comorbidities. STUDY DESIGN AND METHODS: The study comprises intensive phenotyping within 12 months after clinical diagnosis, at 5-year intervals for 20 years and annual telephone interviews in between. Dynamic tests, including glucagon, mixed meal, intravenous glucose tolerance and hyperinsulinemic clamp tests, serve to assess beta-cell function and tissue-specific insulin sensitivity...
2016: Cardiovascular Diabetology
Gemma Chiva-Blanch, Javier Crespo, Rosa Suades, Gemma Arderiu, Teresa Padro, Gemma Vilahur, Judith Cubedo, Dolores Corella, Jordi Salas-Salvadó, Fernando Arós, Miguel-Angel Martínez-González, Emilio Ros, Montse Fitó, Ramon Estruch, Lina Badimon
Circulating microparticles (cMPs) are small phospholipid-rich microvesicles shed by activated cells that play a pivotal role in cell signalling related to the pathogenesis of atherothrombosis. We aimed to investigate the prognostic value of cMPs released from different vascular cells for cardiovascular event (CVE) presentation in asymptomatic patients at high cardiovascular risk factors under nutritional and pharmacologic treatment. This is a nested case-control study of 50 patients from the five-year follow-up prospective PREDIMED trial enrolled in the nuts arm of the Mediterranean diet (MedDiet-nuts)...
July 4, 2016: Thrombosis and Haemostasis
Giuseppe Maulucci, Bareket Daniel, Ofir Cohen, Yossef Avrahami, Shlomo Sasson
Nutrient sensing mechanisms of carbohydrates, amino acids and lipids operate distinct pathways that are essential for the adaptation to varying metabolic conditions. The role of nutrient-induced biosynthesis of hormones is paramount for attaining metabolic homeostasis in the organism. Nutrient overload attenuate key metabolic cellular functions and interfere with hormonal-regulated inter- and intra-organ communication, which may ultimately lead to metabolic derangements. Hyperglycemia and high levels of saturated free fatty acids induce excessive production of oxygen free radicals in tissues and cells...
June 2016: Molecular Aspects of Medicine
Hyeong Sim Choi, Kangwook Lee, Min Kyoung Kim, Kang Min Lee, Yong Cheol Shin, Sung-Gook Cho, Seong-Gyu Ko
Tumor growth requires a process called angiogenesis, a new blood vessel formation from pre-existing vessels, as newly formed vessels provide tumor cells with oxygen and nutrition. Danggui-Sayuk-Ga-Osuyu-Saenggang-Tang (DSGOST), one of traditional Chinese medicines, has been widely used in treatment of vessel diseases including Raynaud's syndrome in Northeast Asian countries including China, Japan and Korea. Therefore, we hypothesized that DSGOST might inhibit tumor growth by targeting newly formed vessels on the basis of its historical prescription...
April 19, 2016: Oncotarget
Konstantinos T Tsaousis, Nikolaos Kopsachilis, Ioannis T Tsinopoulos, Stavros A Dimitrakos, Friedrich E Kruse, Ulrich Welge-Luessen
PURPOSE: To evaluate the efficiency of cultivated human corneal endothelial cells (HCECs) to dehydrate the cornea, using models of the posterior cornea, composed of artificial collagen mass (to represent corneal stroma) and equine collagen membranes (to represent Descemet membrane). METHODS: HCECs were isolated from donor corneal rings and cultivated at 37°C in 5% CO2 and 95% humidified air. The study design included 4 different sets of models: in set 1, the HCECs were placed directly on the collagen mass complex; in set 2, HCECs were placed on a thin equine collagen membrane and laid over the collagen mass; in set 3, HCECs were placed on a thick equine collagen membrane laid over the collagen mass; and in set 4 (the control group), the hydrophilic collagen mass was left alone to interact with the nutritional medium...
May 2016: Cornea
Julia Schumann
BACKGROUND: Both PUFA and miRNAs are believed to be of importance in vascular diseases. On the one hand diverse nutrition societies recommend PUFA consumption to dampen inflammatory processes. On the other hand scientists intensify efforts to use miRNAs for diagnostics or therapy in context of vascular disorders. PRESENTATION OF THE HYPOTHESIS: There might be is a causal link between the plasma membrane lipid composition and the miRNA expression of monocytes and endothelial cells...
March 2016: Medical Hypotheses
Kyoko Hida, Nako Maishi, Chisaho Torii, Yasuhiro Hida
Tumor blood vessels provide nutrition and oxygen to the tumor, resulting in tumor progression. They also act as gatekeepers, inducing tumor metastasis. Thus, targeting tumor blood vessels is an important strategy in cancer therapy. Tumor endothelial cells (TECs), which line the inner layer of blood vessels of the tumor stromal tissue, are the main targets of anti-angiogenic therapy. Because new tumor blood vessels generally sprout from pre-existing vasculature, they have been considered to be the same as normal blood vessels...
April 2016: International Journal of Clinical Oncology
Nadia Calabriso, Marika Massaro, Egeria Scoditti, Simona D'Amore, Antonio Gnoni, Mariangela Pellegrino, Carlo Storelli, Raffaele De Caterina, Giuseppe Palasciano, Maria Annunziata Carluccio
Previous studies have shown the antiinflammatory, antioxidant and antiangiogenic properties by pure olive oil polyphenols; however, the effects of olive oil phenolic fraction on the inflammatory angiogenesis are unknown. In this study, we investigated the effects of the phenolic fraction (olive oil polyphenolic extract, OOPE) from extra virgin olive oil and related circulating metabolites on the VEGF-induced angiogenic responses and NADPH oxidase activity and expression in human cultured endothelial cells. We found that OOPE (1-10 μg/ml), at concentrations achievable nutritionally, significantly reduced, in a concentration-dependent manner, the VEGF-induced cell migration, invasiveness and tube-like structure formation through the inhibition of MMP-2 and MMP-9...
February 2016: Journal of Nutritional Biochemistry
Marcela Cid, Marcelo González
Changes in quality of nutrition, habits, and physical activity in modern societies increase susceptibility to obesity, which can deleteriously affect pregnancy outcome. In particular, a sedentary lifestyle causes dysfunction in blood flow, which impacts the cardiovascular function of pregnant women. The main molecular mechanism responsible for this effect is the synthesis and bioavailability of nitric oxide, a phenomenon regulated by the antioxidant capacity of endothelial cells. These alterations affect the vascular health of the mother and vascular performance of the placenta, the key organ responsible for the healthy development of the fetus...
March 2016: Early Human Development
Kristine C Y McGrath, Xiao-Hong Li, Lucinda S McRobb, Alison K Heather
Oxidative stress and inflammation, leading to endothelial dysfunction, contribute to the pathogenesis of atherosclerosis. The popularity of natural product supplements has increased in recent years, especially those with purported anti-inflammatory and/or antioxidant effects. The efficacy and mechanism of many of these products are not yet well understood. In this study, we tested the antioxidant and anti-inflammatory effects of a supplement, HIPER Health Supplement (HIPER), on cytokine-induced inflammation and oxidative stress in human coronary artery endothelial cells (HCAECs)...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
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