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https://www.readbyqxmd.com/read/29670882/stomal-closure-strategies-to-prevent-incisional-hernia
#1
Rhiannon L Harries, Jared Torkington
Incisional hernias following ostomy reversal occur frequently. Incisional hernias at the site of a previous stoma closure can cause significant morbidity, impaired quality of life, lead to life-threatening hernia incarceration or strangulation and result in a significant financial burden on health care systems Despite this, the evidence base on the subject is limited. Many recognised risk factors for the development of incisional hernia following ostomy reversal are related to patient factors such as age, malignancy, diabetes, COPD, hypertension and obesity, and are not easily correctable...
2018: Frontiers in Surgery
https://www.readbyqxmd.com/read/29644509/applications-of-colon-capsule-endoscopy
#2
REVIEW
Shabana F Pasha
PURPOSE OF REVIEW: This is a review of colon capsule endoscopy (CCE) with a focus on its recent developments, technological improvements, and current and potential future indications. RECENT FINDINGS: Based on the current literature, CCE II demonstrates comparable polyp detection rates as optical colonoscopy and CT colonography, and improved cost-effectiveness. The main limitation to patient acceptance is the requirement of a rigorous bowel preparation. Preliminary studies show good correlation between CCE and optical colonoscopy for assessment of colonic disease activity in inflammatory bowel disease (IBD)...
April 12, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29628630/interfraction-variations-in-organ-filling-and-their-impact-on-dosimetry-in-ct-image-based-hdr-intracavitary-brachytherapy
#3
Ramya Rangarajan
Aim: Since anatomical and geometric variations occur with every fraction, planning, and dose optimization is necessary for every fraction of high-dose rate intracavitary brachytherapy of carcinoma cervix. In this study, we have tried to quantify the differences in doses to organs at risk (OAR) for each fraction of brachytherapy. Methods and Materials: One hundred and seventy computed tomography datasets of cervical cancer patients receiving intracavitary brachytherapy at our institution between January and April 2015 were analyzed...
January 2018: Journal of Medical Physics
https://www.readbyqxmd.com/read/29620784/prebiotic-effects-of-resistant-starch-from-purple-yam-dioscorea-alata-l-on-the-tolerance-and-proliferation-ability-of-bifidobacterium-adolescentis-in-vitro
#4
Tao Li, Lei Chen, Jianbo Xiao, Fengping An, Cheng Wan, Hongbo Song
The in vitro prebiotic effects of resistant starch (RS), prepared by different treatments from purple yam, on Bifidobacterium adolescentis (bifidobacteria for short), were investigated. Tolerance tests indicated that bifidobacteria in PDS (prepared by debranching combined with autoclaving) and PDS.H (PDS further treated by double enzyme hydrolysis) media adapted better to simulated upper gastrointestinal conditions (at pH 1.5-3.0 and 0.3% and 1.0% bile acid) than those in GLU (glucose) and DAS (prepared by autoclaving) media...
April 5, 2018: Food & Function
https://www.readbyqxmd.com/read/29618177/pediatric-colonoscopy-the-changing-patterns-and-single-institutional-experience-over-a-decade
#5
REVIEW
Jae Hong Park
The safety and effectiveness of pediatric colonoscopy for lower gastrointestinal tract diseases have been established in Korea for about 30 years. Both diagnostic and therapeutic colonoscopies have had many advances in terms of operator skill and experience and are now being performed by most pediatric gastroenterologists. Pediatric colonoscopy is different in many aspects from that of adults, such as expected diagnoses, patient management, bowel preparation, selection criteria for sedation, and instrument selection...
March 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/29617306/development-of-colorectal-targeted-dietary-supplement-tablets-containing-natural-purple-rice-bran-oil-as-a-colorectal-chemopreventive
#6
Busaban Sirithunyalug, Chalermpong Saenjum, Suporn Charumanee, Bhagavathi Sundaram Sivamaruthi, Chaiyavat Chaiyasut, Jakkapan Sirithunyalug, Pratchaya Tipduangta
Colorectal cancer occurs due to various factors. The important risks are dietary lifestyle and inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. It has been found that the inhibitory enzyme cyclooxygenase-2 (COX-2) in the colorectal region can potentially reduce the risk of colorectal cancer. The present study investigated rice bran oil from natural purple rice bran, which exhibits antioxidant and anti-inflammatory activity. This study aimed to evaluate the bioactive compound content of natural purple rice bran oil (NPRBO) derived from native Thai purple rice and the anti-inflammatory activity of NPRBO in colorectal cancer cells, and to develop a colorectal delivery platform in the form of film-coated tablets...
April 4, 2018: Nutrients
https://www.readbyqxmd.com/read/29616238/development-and-validation-of-an-automated-algorithm-to-evaluate-the-abundance-of-bubbles-in-small-bowel-capsule-endoscopy
#7
Olivia Pietri, Gada Rezgui, Aymeric Histace, Marine Camus, Isabelle Nion-Larmurier, Cynthia Li, Aymeric Becq, Einas Abou Ali, Olivier Romain, Ulriikka Chaput, Philippe Marteau, Christian Florent, Xavier Dray
Background and study aims : Bubbles can impair visualization of the small bowel (SB) mucosa during capsule endoscopy (CE). We aimed to develop and validate a computed algorithm that would allow evaluation of the abundance of bubbles in SB-CE still frames. Patients and methods : Two sets of 200 SB-CE normal still frames were created. Two experienced SB-CE readers analyzed both sets of images twice, in a random order. Each still frame was categorized as presenting with < 10 % or ≥ 10 % of bubbles...
April 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29614542/-gastrointestinal-bleeding-update
#8
Jonel Trebicka, Martin Götz
PREENDOSCOPIC MANAGEMENT:  In suspected gastrointestinal bleeding (GIB), standard operating procedures help in risk stratification, early patient management and endoscopy. If variceal bleeding is suspected, specific medication (vasoconstrictors, antimicrobial therapy) are additive to standard pharmacological management (PPI, erythromycin) prior to endoscopy. COAGULATION REQUIRMENTS:  An emergency endoscopy can be performed independent of the patient's current coagulation status...
April 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29609829/is-the-virtual-colonoscopy-a-replacement-for-optical-colonoscopy
#9
REVIEW
Andrew Guinigundo
OBJECTIVE: To examine the viability of colon cancer screening with computed tomography colonography, also known as virtual colonoscopy. DATA SOURCES: Clinical guidelines, published medical research. CONCLUSION: Virtual colonoscopy, under the right circumstances, is an accurate viable screening tool for patients who may not otherwise desire to or are not able to participate in traditional colonoscopy. IMPLICATIONS FOR NURSING PRACTICE: Nurses should be aware that routine colon cancer screening is recommended starting at age 50...
March 30, 2018: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/29605976/clinical-practice-guidelines-for-irritable-bowel-syndrome-in-korea-2017-revised-edition
#10
REVIEW
Kyung Ho Song, Hye-Kyung Jung, Hyun Jin Kim, Hoon Sup Koo, Yong Hwan Kwon, Hyun Duk Shin, Hyun Chul Lim, Jeong Eun Shin, Sung Eun Kim, Dae Hyeon Cho, Jeong Hwan Kim, Hyun Jung Kim
In 2011, the Korean Society of Neurogastroenterology and Motility (KSNM) published clinical practice guidelines on the management of irritable bowel syndrome (IBS) based on a systematic review of the literature. The KSNM planned to update the clinical practice guidelines to support primary physicians, reduce the socioeconomic burden of IBS, and reflect advances in the pathophysiology and management of IBS. The present revised version of the guidelines is in continuity with the previous version and targets adults diagnosed with, or suspected to have, IBS...
April 30, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29605261/reality-check-what-happens-when-patients-with-anorectal-malformations-grow-up-a-pilot-study-of-medical-care-transition-from-the-adult-patient-perspective
#11
Annelotte van der Bent, Eileen M Duggan, Laurie N Fishman, Belinda Hsi Dickie
BACKGROUND: There has been an increased focus on transition of pediatric and adolescent patients to adult centered care. For patients with rare and complex conditions, such as anorectal malformations (ARM), difficulties are compounded by the absence of structured transition protocols and lack of adult provider expertise. We sought to explore the actual experiences of adult patients with ARM and distinguish if there are factors that influence the ability to achieve satisfactory transition to adult centered medical care...
March 2, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29603358/rapid-review-shows-that-probiotics-and-fermented-infant-formulas-do-not-cause-d-lactic-acidosis-in-healthy-children
#12
REVIEW
J Łukasik, S Salminen, H Szajewska
AIM: Extensive on-going research on probiotics and infant formulas raises a number of safety questions. One concern is the potential influence of D-lactic acid-containing preparations on the health of infants and children. The aim of this review was to summarise the available knowledge on the ingestion of D-lactic acid-producing bacteria, acidified infant formulas and fermented infant formulas as a potential cause of paediatric D-lactic acidosis. METHODS: A Medline database search was performed in July 2017, with no restrictions on the language, article type or publication date...
March 30, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29603317/innovative-discharge-process-for-families-with-pediatric-short-bowel-syndrome-a-prospective-nonrandomized-trial
#13
Bram P Raphael, Maria Jorina, Mary Gallotto, Glendalis Grullon, Meghan Dalton, Melissa Takvorian-Bené, Christina Tascione, Carolyn Rosa, Jennifer McClelland, Megan Gray, Alexis K Potemkin, Courtney Glavin, Kathleen M Gura, Margaret K Murphy, Kierrah Leger, Judith Mahoney, Jessica Kerr, Al Ozonoff, Christopher P Duggan
BACKGROUND: Home parenteral nutrition (HPN) is a life-sustaining therapy for short bowel syndrome (SBS) and other severe digestive diseases, but complications are common. We evaluated a predischarge HPN hands-on training course to reduce complications in children with SBS, including hospital readmissions. METHODS: We conducted a prospective, nonrandomized controlled research study between April 1, 2014, and April 30, 2017. Eligible participants were children aged <18 years old with SBS and anticipated HPN dependence duration ≥6 months...
March 30, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29594710/correction-to-effect-of-a-preparation-of-four-probiotics-on-symptoms-of-patients-with-irritable-bowel-syndrome-association-with-intestinal-bacterial-overgrowth
#14
Konstantinos Leventogiannis, Paraskevas Gkolfakis, Georgios Spithakis, Aikaterini Tsatali, Aikaterini Pistiki, Athanasios Sioulas, Evangelos J Giamarellos-Bourboulis, Konstantinos Triantafyllou
The original version of this article contained mistakes, and the authors would like to correct them. The correct details are given below.
March 28, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29588842/factors-associated-with-the-efficacy-of-polyp-detection-during-routine-flexible-sigmoidoscopy
#15
Akash J Maliampurakal, Donald C McMillan, John H Anderson, Paul G Horgan, David Mansouri
Objective: Flexible sigmoidoscopy reduces the incidence of colonic cancer through the detection and removal of premalignant adenomas. However, the efficacy of the procedure is variable. The aim of the present study was to examine factors associated with the efficacy of detecting polyps during flexible sigmoidoscopy. Design and patients: Retrospective observational cohort study of all individuals undergoing routine flexible sigmoidoscopy in NHS Greater Glasgow and Clyde from January 2013 to January 2016...
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29580419/redox-sensitive-nanoparticles-based-on-4-aminothiophenol-carboxymethyl-inulin-conjugate-for-budesonide-delivery-in-inflammatory-bowel-diseases
#16
Qijuan Sun, Lin Luan, Muhammad Arif, Jiaxin Li, Quan-Jiang Dong, Yuanyuan Gao, Zhe Chi, Chen-Guang Liu
The purpose of this study was to develop an oral nanocarrier as budesonide delivery system and to evaluate its therapeutic potential for inflammatory bowel disease (IBD). The nanoparticles (NPs) based on an amphiphilic inulin polymer with 4-aminothiophenol (ATP) grafted onto carboxymethyl inulin (CMI) were prepared. The particle sizes were about 210.18 nm and had the obvious pH/redox sensitive swelling transitions. The drug-release study of NPs <-- >in vitro showed a low release rate (about 45 wt%) in GSH-free media, whereas high release rate (about 80 wt%) in the media containing 20 mM GSH, exhibiting a redox-responsive property...
June 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29577847/when-your-pregnancy-echoes-your-illness-transition-to-motherhood-with-inflammatory-bowel-disease
#17
Jihane Ghorayeb, Peter Branney, Christian P Selinger, Anna Madill
Our aim is to provide an understanding of the experience of women with inflammatory bowel disease (IBD) who have made the transition to motherhood. A total of 22 mothers with IBD were recruited from around the United Kingdom. Semi-structured interviews were conducted and analyzed using thematic analysis. The central concept- Blurred Lines-offers a novel frame for understanding the transition to motherhood with IBD through identifying parallels between having IBD and becoming, and being, a mother. Parallels clustered into three main themes: Need for Readiness, Lifestyle Changes, and Monitoring Personal and Physical Development...
March 1, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29575372/radar-plots-a-novel-modality-for-displaying-disparate-data-on-the-efficacy-of-eluxadoline-for-the-treatment-of-irritable-bowel-syndrome-with-diarrhea
#18
D M Brenner, L S Dove, D A Andrae, P S Covington, C Gutman, W D Chey
BACKGROUND: Patients with irritable bowel syndrome with diarrhea (IBS-D) experience a range of abdominal and bowel symptoms; successful management requires alleviation of this constellation of symptoms. Eluxadoline, a locally active mixed μ- and κ-opioid receptor agonist and δ-opioid receptor antagonist, is approved for the treatment of IBS-D in adults based on the results of 2 Phase 3 studies. Radar plots can facilitate comprehensive, visual evaluation of diverse but interrelated efficacy endpoints...
March 25, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29564651/effectiveness-of-mechanical-bowel-preparation-versus-no-preparation-on-anastomotic-leakage-in-colorectal-surgery-a-systematic-review-and-meta-analysis
#19
REVIEW
Jobbe P L Leenen, Judith E K R Hentzen, Henrietta D L Ockhuijsen
It has been a standard practice to perform mechanical bowel preparation (MBP) prior to colorectal surgery to reduce the risk of colorectal anastomotic leakages (CAL). The latest Cochrane systematic review suggests there is no benefit for MBP in terms of decreasing CAL, but new studies have been published. The aim of this systematic review and meta-analysis is to update current evidence for the effectiveness of preoperative MBP on CAL in patients undergoing colorectal surgery. Consequently, PubMed, MEDLINE, Embase, CENTRAL and CINAHL were searched from 2010 to March 2017 for randomised controlled trials (RCT) that compared the effects of MBP in colorectal surgery on anastomotic leakages...
March 21, 2018: Updates in Surgery
https://www.readbyqxmd.com/read/29563879/trek-1-channel-expression-in-smooth-muscle-as-a-target-for-regulating-murine-intestinal-contractility-therapeutic-implications-for-motility-disorders
#20
Ruolin Ma, Mohsen Seifi, Maria Papanikolaou, James F Brown, Jerome D Swinny, Anthony Lewis
Gastrointestinal (GI) motility disorders such as irritable bowel syndrome (IBS) can occur when coordinated smooth muscle contractility is disrupted. Potassium (K+ ) channels regulate GI smooth muscle tone and are key to GI tract relaxation, but their molecular and functional phenotypes are poorly described. Here we define the expression and functional roles of mechano-gated K2P channels in mouse ileum and colon. Expression and distribution of the K2P channel family were investigated using quantitative RT-PCR (qPCR), immunohistochemistry and confocal microscopy...
2018: Frontiers in Physiology
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