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meibomian gland carcinoma

Jacob Pe'er
The eyelids are composed of four layers: skin and subcutaneous tissue including its adnexa, striated muscle, tarsus with the meibomian glands, and the palpebral conjunctiva. Benign and malignant tumors can arise from each of the eyelid layers. Most eyelid tumors are of cutaneous origin, mostly epidermal, which can be divided into epithelial and melanocytic tumors. Benign epithelial lesions, cystic lesions, and benign melanocytic lesions are very common. The most common malignant eyelid tumors are basal cell carcinoma in Caucasians and sebaceous gland carcinoma in Asians...
March 2016: Indian Journal of Ophthalmology
Leilei Zhang, Xiaolin Huang, Xiaowei Zhu, Shengfang Ge, Eric Gilson, Renbing Jia, Jing Ye, Xianqun Fan
Meibomian gland carcinoma (MGC) and basal cell carcinoma (BCC) are common eyelid carcinomas that exhibit highly dissimilar degrees of proliferation and prognoses. We address here the question of the differential mechanisms between these two eyelid cancers that explain their different outcome. A total of 102 confirmed MGC and 175 diagnosed BCC cases were analyzed. Twenty confirmed MGC and twenty diagnosed BCC cases were collected to determine the telomere length, the presence of senescent cells, and the expression levels of the telomere capping shelterin complex, P53, and the E3 ubiquitin ligase Siah1...
March 15, 2016: International Journal of Cancer. Journal International du Cancer
Jerry A Shields, Jarin Saktanasate, Sara E Lally, Jacqueline R Carrasco, Carol L Shields
Sebaceous carcinoma is a malignancy arising in the periocular region that can lead to blindness and tumor-related metastases. This study is a review of published literature and personal experience. This malignancy can arise from the sebaceous units in the tarsus (meibomian glands), in association with the cilia (Zeis glands), in the brow, and in the caruncle. There is a tendency for diffuse intraepithelial growth (pagetoid spread) that can be clinically invisible. Detection before lymph node metastasis is critical...
July 2015: Asia-Pacific Journal of Ophthalmology
Tomasz Zieliński, Bogusław Antoszewski
Sebaceous carcinoma of the eyelid is a very rare, slow growing, malignant tumor. Most ocular sebaceous carcinomas originate in the tarsal meibomian glands. It commonly occurs in the sixth to eighth decade of life, with preponderance for women and Asians. The upper eyelid is affected more frequently. The disease can spread directly by orbital invasion, lymphatic spread to regional lymph nodes and hematogenous spread to distant organs. Correct diagnosis of sebaceous carcinoma is often delayed due to its resemblance to a variety of benign conditions of the eyelids such as chalasion or chronic blepharoconjunctivitis...
2014: Klinika Oczna
Y C Wang, H Y Dai, X Xing, C Lv, J Zhu, C Y Xue
PURPOSE: To explore the clinical effect of the pedicled lower lid-sharing flap for full-thickness reconstruction of the upper eyelid . METHODS: From 2009 to 2013, 13 upper eyelids with meibomian gland carcinoma (13 patients, age range 52-78 years) were excised, and immediately reconstructed with a pedicled lower lid-sharing flap used for full-thickness upper eyelid defects (up to two-thirds of the eyelid width). Traditionally, the flap is divided after 3 to 4 weeks, and the recipient site closed directly...
November 2014: Eye
Syed Ali Raza Rizvi, Veena Maheshwari
Sebaceous gland carcinomas (SGC) are highly malignant lid tumors which originate from meibomian glands and rarely from the gland of Zeis, sebaceous gland of caruncle, eyebrows and periocular skin. In many cases correct diagnosis of SGC is delayed because of its ability to masquerade as a variety of other ocular conditions. A forty year old male presented with a left upper eyelid swelling with an ulcerated wound on its nasal aspect. A differential diagnosis of sebaceous gland carcinoma or preseptal cellulitis was made...
2010: Journal of Surgical Case Reports
Yi-chen Liang, Tao Zhang, Sheng Chen, Dan-dan Yu, Hong-ge Wu
PURPOSE: To observe the curative effect of Xeloda in meibomian gland carcinoma. METHODS: We treated a 53-year-old woman, who had recrudescent meibomian gland carcinoma, with Xeloda. RESULTS: The mass was much smaller with decreased amount of overflow pus after 4 cycles of chemotherapy with Xeloda. CONCLUSIONS: Xeloda played a significant role in treating recrudescent meibomian gland carcinoma in this patient.
March 2014: European Journal of Ophthalmology
Kalpana Pandey, Parul Singh, Abhishek Singh, Harishanker Pandey
Sebaceous gland carcinoma usually arises from the meibomian or Zeis glands within the eyelid, but tumor arising primarily from the conjunctiva, especially bulbar conjunctiva, is a rarity. We hereby report a case of a 50-year-old female who presented with a painless mass in the inferior limbus, encroaching the cornea and hanging over the lower eyelid without involving it. Imprint cytology was suggestive of adenosquamous carcinoma. Management consisted of wide local excision, cryotherapy to tumor bed, and topical 5-fluorouracil (5-FU) 1% preoperatively and postoperatively...
May 2011: Oman Journal of Ophthalmology
Dongjin Sung, Sara A Kaltreider, Federico Gonzalez-Fernandez
BACKGROUND: Ocular sebaceous carcinoma can masquerade as benign lesions resulting in delay of diagnosis. Early recognition is even more difficult in young patients where the disease rarely occurs. Here, we provide a clinicopathological correlation of ocular sebaceous carcinoma in a young individual lacking history of hereditary cancer or immunosuppression. FINDINGS: A detailed histopathological study including p53 DNA sequencing was performed on an aggressive sebaceous carcinoma presenting in a healthy 32 year-old Caucasian woman...
2011: Diagnostic Pathology
Man Li, Xiao-mei Wu, Gan-di Li, Rui-nan Xia
OBJECTIVE: To explore the methods to establish a xenografted model of meibomian gland carcinoma in nude mice, then find the best method to establish the animal model. The last purpose of this study was to establish a suitable animal model for clinic therapy and basic research of meibomian gland carcinoma. METHODS: Small pieces of meibomian gland carcinoma tissue from four patients were transplanted subcutaneously in the flanks of eight nude mice through a skin incision...
March 2011: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
N Passi, U Chawala, Jyoti, A K Khurana
BACKGROUND: Pilomatrixoma , also known as Malherbes's calcifying epithelioma, known to occur in children, is not common especially in middle aged and those below 10 years of age . Pilomatrixoma presents as a firm skin nodule on eye lid or eye brow, so should be considered in the differential diagnosis of such lesions involving eyelids. CASE: A 45-year-old male presented with a swelling in the left upper lid for the last 4 months. There was firm to hard non tender nodule measuring 1...
January 2011: Nepalese Journal of Ophthalmology
Li-Wei Kan, Yi-Shing Leu, Chi-Yuan Tzen, Chien-Hsiu Wu
Sebaceous gland carcinoma (SGC) of the eyelid is a highly malignant neoplasm that arises from the meibomian glands, glands of Zeis, and sebaceous glands of the skin. The characteristics of this disease are high recurrence rate, significant metastatic potential, and notable mortality rate, which are quite different from basal cell carcinoma (BCC). We report the case of a 37-year-old woman with the history of left lower eyelid BCC (diagnosed 9 years ago), who had left parotid lymph nodes metastases and local recurrence twice...
November 2011: American Journal of Otolaryngology
Nezihe Gokhan, Mahmut Sozmen, Burhan Ozba, Emine Gungor
OBJECTIVE: To describe the clinical and pathomorphological features of meibomian carcinoma (MC) diagnosed in a Simmental cow. MATERIAL AND METHODS: A 7-year-old Simmental cow was admitted to the Veterinary Surgery Clinics of Faculty of Veterinary Medicine, University of Kafkas, Kars, Turkey. The signalment and anatomical distribution were summarized and focused on pathomorphological description. RESULTS: Macroscopically, a papillary mass, 5 × 3...
September 2010: Veterinary Ophthalmology
Ilse Mombaerts, Annelies Gillis
BACKGROUND: The midline forehead flap is used in the reconstruction of large, deep defects of the medial canthal area and lower eyelid. Drawbacks are a cosmetically unfavorable skin bulge at the nasal bridge and obliteration of the natural medial canthal concavity, requiring correction in a second stage. OBJECTIVE: We adopted a modification of the technique to avoid these drawbacks. METHODS: We reviewed the medical records and photographs of patients who received the tunneled midline forehead flap procedure in the repair of medial canthal defects and in the anterior lamellar repair of eyelid defects...
July 2010: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Mihaela Cristiana Coroi, Elena Roşca, Gabriela Muţiu, T Coroi, Marinela Bonta
The work assessment is to analyze eyelid tumors diagnosed in the last years in our hospital. We found 471 tumoral and pseudotumoral cases, in which malignant tumors predominated, with 255 cases. The most affected age range was the sixth decade and the majority of tumors were located to lower eyelid. The histopathological study allowed us to establish the lesions type and subtype. The Meibomian gland cysts, squamous papillomas and basal cell carcinomas were the most frequent related with this three of category lesions represented by pseudotumors, benign tumors and malignant tumors...
2010: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Panayota K Rigas, Satoru Kase, Narsing A Rao
PURPOSE: Crystallins are molecular chaperones that protect various cells from apoptosis. This study used immunohistochemistry to examine the expression of alphaA-crystallin and alphaB-crystallin in human sebaceous carcinoma tissues. METHODS: Nine patients with sebaceous carcinoma of the eyelid underwent excision of the eyelid or orbital exenteration. Formalin-fixed, paraffin-embedded tissue sections were submitted for hematoxylin-eosin staining and immunohistochemistry with anti-alphaA- and alphaB-crystallin antibodies...
September 2009: European Journal of Ophthalmology
Yasuhiko Hayashi, Hiroshi Shima, Daisuke Kita, Masashi Kinoshita, Yuya Yoshida, Mitsuhiro Hasegawa, Jun-ichiro Hamada
A 41-year-old man presented with exophthalmos and loss of visual acuity. Neuroradiological studies showed a large mass extending from the intraorbital region to the frontal lobe. In addition, it also involved the middle cranial and infratemporal fossae with accompanying skull destruction. The tumor was almost totally removed. The histological diagnosis was sebaceous carcinoma with pagetoid changes. Despite surgery and local irradiation, intracranial metastases were recognized one year later, and the patient underwent total tumor removal and whole-brain irradiation...
April 2009: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Rong-Jia Chen, Yi-Qin Xiao
OBJECTIVE: To study the histopathological classification and changes of eyelid neoplasms. METHOD: In this retrospective case series, the pathological specimens of 2734 cases with eyelid neoplasms examined between 1993-2005 were claimed and analyzed. RESULTS: There were 1248 eyelid tumors (45.65%) in 2734 cases with eyelid neoplasms, including 875 benign neoplasms (71.11%) and 960 malignant cases (29.89%). The three leading malignant eyelid tumors were basal cell carcinoma, meibomian gland carcinoma and squamous cell carcinoma The mean ages of the occurrence of these three tumors were 64...
February 2008: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Arun Kumar, Syril Kumar Dorairaj, Venkatesh C Prabhakaran, D Ravi Prakash, Sanjukta Chakraborty
Meibomian cell carcinoma (MCC) is a malignant tumor of the meibomian glands located in the eyelids. No information exists on the cytogenetic and genetic aspects of MCC. There is no report on the gene expression profile of MCC. Thus there is a need, for both scientific and clinical reasons, to identify genes and pathways that are involved in the development and progression of MCC. We analyzed the gene expression profile of MCC by the microarray technique. Forty-four genes were upregulated and 149 genes were downregulated in MCC...
November 2007: Genomics
Rajendra S Garbyal, Prajwala Gupta, Mohan Kumar, Anshu Bohra, Amita Chaube
OBJECTIVE: To reevaluate and reestablish the reproducible diagnostic cytomorphologic features of meibomian gland carcinoma (MGCA), demonstrating the importance of fine needle aspiration cytology (FNAC) in eyelid lesions and leading to better management of the tumor. STUDY DESIGN: Cytologic smears ofpreviously diagnosed cases of MGCA over a 3-year period were collected, along with their histopathology reports. The cytomorphology of the histopathologically proven cases were reevaluated in greater detail...
March 2007: Acta Cytologica
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